João David Panão da Costa (D812-B92E-4FCD)

Curriculum Vitae

João David Panão da Costa

João David Panão da Costa. Completed the Mestrado integrado in Pharmaceutical Sciences in 2017/09/22 by Universidade de Coimbra Faculdade de Farmácia. Attends the Doutoramento in PhD in Pharmaceutical Sciences (Pharmaceutical Technology) by Universidade de Coimbra Faculdade de Farmácia since 2018/07/03. Is PhD student working on the project: "Development of a therapeutic hepatitis B vaccine: designing a particulate-based multicomponent prototype for immunomodulation" in Fundação para a Ciência e a Tecnologia. Published 3 articles in journals. Participated in 1 event(s). Has received 3 awards and/or honors. Participates and/or participated as Master Student Fellow in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Health-Related Biotechnology, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Immunology, Medical and Health Sciences with emphasis on Clinical Medicine with emphasis on Gastroenterology and hepatology, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials, Natural sciences with emphasis on Biological Sciences with emphasis on Virology and Medical and Health Sciences with emphasis on Health Sciences with emphasis on Infectious Diseases. In their professional activities interacted with 16 collaborator(s) co-authorship of scientific papers.

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Identification

Personal identification

Full name: João David Panão da Costa

Citation names

Panão Costa, João
Costa, João

Author identifiers

Ciência ID: D812-B92E-4FCD
ORCID iD: 0000-0002-2414-8945

Email addresses

jpanao94@gmail.com (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Clinical Medicine - Gastroenterology and hepatology
Medical and Health Sciences - Medical Biotechnology - Biomaterials
Natural sciences - Biological Sciences - Virology
Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2023/03/06 - 2023/03/08 Attended	Flow Cytometry and Cell Sorting - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Outros) CNC.IBILI, Portugal
2018/07/03 - 2022/09/30 Ongoing	PhD in Pharmaceutical Sciences (Pharmaceutical Technology) (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/07/15 Concluded	Course on Laboratory Animal Science, Felasa Category B (Outros) Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2019/03/28 Attended	Training Course on Adjuvants and Vaccine Formulation (Outros) Vaccine Formulation Institute, Switzerland
2019/01/18 Attended	Course on Biostatistics (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/08/20 - 2018/06/02 Concluded	Pharmaceutical Biotechnology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Farmácia, Portugal	17
2012/09/10 - 2017/09/22 Concluded	Pharmaceutical Sciences (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal "Internship Reports and Monograph titled "Chitosan-based Nanoparticles for Gene Delivery"" (THESIS/DISSERTATION)	16

Affiliation

Science

	Category Host institution	Employer
2023/07/19 - Current	Researcher (Research)	Universidade de Coimbra, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal (...)
2018/04/16 - 2018/12/31	Researcher (Research)	CNC.IBILI, Portugal
	Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/25 - 2018/04/13	Research Trainee (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/11/14 - 2017/09/22	Research Trainee (Research)	Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

	Category Host institution	Employer
2019/01/01 - Current	PhD student working on the project: "Development of a therapeutic hepatitis B vaccine: designing a particulate-based multicomponent prototype for immunomodulation"	Fundação para a Ciência e a Tecnologia, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal (...)

Projects

Grant

	Designation	Funders
2021/10/10 - 2022/12/31	Vacina Intranasal genética contra o COVID: estudos de imunização em murganhos 13824 Researcher	Gilead Sciences Lda
2018 - 2021	Hepatitis B therapeutic vaccine: Production of glucan-based particles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity - POCI-01-0145-FEDER-030331 POCI-01-0145-FEDER-030331 Researcher
2018/04 - 2019/12	Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions - ProSafe JTC/0001/2016 ProSafe JTC/0001/2016 Master Student Fellow	Concluded

Contract

	Designation	Funders
2023/07/19 - Current	CInTech: Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs 7131 Researcher CNC.IBILI, Portugal Bluepharma, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Ongoing

Outputs

Publications

Book chapter	Colaço, Mariana; Panão Costa, João; Borges, Olga. "Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant". In Methods in Molecular Biology, 269-280. Springer US, 2021. 10.1007/978-1-0716-1892-9_13
Conference poster	Batista, Ana; Nikitin, T.; Cardoso, H.; Voronoska, A.; Panão Costa, João; Pedroso, S.; Amaral, A. T.; Moreira, J. N.. Corresponding author: Batista, Ana. "Towards tracing lipid-nanoparticle intracellular trafficking in cancer cells by confocal Raman microscopy". Paper presented in 6th ASPIC International Congress, 2024. Panão Costa, João; Colaço, M.; Félix, P.; Melo, A. A.; Lebre, F.; Cruz, M. T.; Alfaro-Moreno, E.; Moreira, J. N.; Borges, O.. Corresponding author: Panão Costa, João. "ß-glucan polymeric microparticles: innovating cancer immunotherapy through targeted antigen delivery". Paper presented in 6th ASPIC International Congress, 2024. Félix, Paulo; Panão Costa, João; Colaço, Mariana; Borges, Olga. "Toll-like Receptor Ligands as Oral Vaccine Adjuvants: Immunomodulatory Effects against SARS-CoV-2". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas. Coimbra, Portugal, 2023. A. Melo, Alexandra; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Effect of the Roots of Withania somnifera Encapsulated Into ß-Glucan Particles". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas. Coimbra, Portugal, 2023. Félix, Paulo; Panão Costa, João; Colaço, Mariana; Borges, Olga. "The immunomodulatory potential of a dual TLR agonist strategy as an oral vaccine adjuvant for SARS-CoV-2". Paper presented in iMed Conference 15.0 Lisbon 2023, 2023. FÉLIX, PAULO; Panão Costa, João; Colaço, Mariana; Borges, Olga. "The immunomodulatory potential of a dual TLR agonist strategy as a vaccine adjuvant". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS), 2023. Colaço, Mariana; Panão Costa, João; Jesus, Sandra; Borges, Olga. "The contamination of nanoparticles with endotoxins does not always influence immunotoxicity studies: chitosan as a case study". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS), 2023. Panão Costa, João; Colaço, Mariana; Jesus, Sandra; Borges, Olga. Corresponding author: Panão Costa, João. "Immunotoxicological properties of yeast-derived glucan particles". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022. Jesus, Sandra; Duarte, Henrique; Panão Costa, João; Colaço, Mariana; Borges, Olga. "Inulin-PCL nanoparticles as an adjuvant delivery system for highly purified recombinant antigens". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022. Colaço, Mariana; Panão Costa, João; Roquito, Tiago; Jesus, Sandra; Borges, Olga. "Evaluation of the hemocompatibility and immunotoxicity properties of two sized curcumin-loaded glucan nanoparticles". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022. Jesus, Sandra; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Chronic Hepatitis B (CHB) vaccine: Shedding light on the immunotoxicity of chitosan as a nano-delivery system". Paper presented in CIBB Metting, Coimbra, Portugal, 2019. Jesus, Sandra; Da Silva, Jessica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester nanoparticles: Relationship between structure and activity". Paper presented in 46th Controlled Release Society Annual Meeting & Exposition, Valencia, Spain, 2019. Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Colaço, Mariana; Panão Costa, João; Som, Claudia; et al. "Safe-by-design of chitosan nanoparticles: the role of immunotoxicological properties". Paper presented in SPI XLV Annual Meeting, Coimbra, Portugal, 2019. Jesus, Sandra; Da Silva, Jéssica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester Nanoparticle Immunotoxicological Profile". Paper presented in SPI XLV Annual Meeting, Coimbra, Portugal, 2019. Raquel Araújo; Mariana Colaço; Panão Costa, João; Natalia Bernardi; Sandra Jesus; Olga Borges. "Nanocapsules containing sucupira oil: cytotoxicity and hemolysis evaluation". Paper presented in 22nd International Symposium on Microencapsulation, 2019. Duarte, Alana; Marques, Ana Patrícia; Jesus, Sandra; Panão Costa, João; Soares, Edna; Colaço, Mariana; Borges, Olga. "Assessment of immunotoxicological features of chitosan nanoparticles.". Paper presented in 2nd SPLC-CRS Young Scientists Meeting, Santiago de Compostela, Spain, 2019. Panão Costa, João; Jesus, Sandra; Soares, Edna; Borges, Olga. "Chitosan-based nanoparticles for gene delivery". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Coimbra, Portugal, 2018.
Journal article	Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Borges, Olga. "Exploring the immunomodulatory properties of glucan particles in human primary cells". International Journal of Pharmaceutics 655 123996 (2024): https://www.sciencedirect.com/science/article/pii/S0378517324002308?via%3Dihub. Open access • Published Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Duarte, Alana; Soares, Edna; Borges, Olga. Corresponding author: Borges, Olga. "Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies.". Vaccine 41 23 (2023): 3481-3485. Published • https://doi.org/10.1016/j.vaccine.2023.04.063 Colaço, Mariana; Roquito, Tiago; Panão Costa, João; Cruz, Maria Teresa; Borges, Olga. Corresponding author: Borges, Olga. "The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute". Pharmaceutics 15 2 (2023): 623. http://dx.doi.org/10.3390/pharmaceutics15020623. Published • 10.3390/pharmaceutics15020623 Jesus, Sandra; Bernardi, Natalia; da Silva, Jessica; Colaço, Mariana; Panão Costa, João; Fonte, Pedro; Borges, Olga. "Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends". Chemical Research in Toxicology 33 11 (2020): 2819-2833. Published Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al. "Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00100. Open access • Published • 10.3389/fbioe.2020.00100 Panão Costa, João; Carvalho, Sofia; Jesus, Sandra; Soares, Edna; Marques, Ana Patrícia; Borges, Olga. "Optimization of Chitosan-a-casein Nanoparticles for Improved Gene Delivery: Characterization, Stability, and Transfection Efficiency". AAPS PharmSciTech 20 3 (2019): http://dx.doi.org/10.1208/s12249-019-1342-y. Published • 10.1208/s12249-019-1342-y Jesus, Sandra; Soares, Edna; Costa, João; Borchard, Gerrit; Borges, Olga. "Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-e-caprolactone based nanoparticles". International Journal of Pharmaceutics 504 1-2 (2016): 59-69. http://dx.doi.org/10.1016/j.ijpharm.2016.03.013. Published • 10.1016/j.ijpharm.2016.03.013
Thesis / Dissertation	Panão Costa, João. "Chitosan-based nanoparticles for gene delivery". Master, Universidade de Coimbra Faculdade de Farmácia, 2017.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/02/14	Hepatic-Targeted Dual Oral Vaccine Formulation for Chronic Hepatitis B: Amplifying Immune Efficacy with Glucan Particles.	XV Spanish Portuguese Conference on Controlled Drug Delivery (Lisbon, Portugal)
2023/02/06	ß-glucan and TLR 7/8 agonist combination as a new adjuvant against chronic hepatitis B	4th SPLC-CRS Young Scientists Meeting Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS) (Porto, Portugal)
2022/02/10	Immunotoxicological properties of yeast-derived glucan particles	SPF Meeting 2022 Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2021/07/27	The immunostimulatory ability of glucan particles on human DCs: a promising platform for the design of a chronic hepatitis B vaccine	Controlled Release Society 2021 Virtual Annual Meeting Controlled Release Society (CRS)
2019/02/07	Endotoxin-free chitosan does not stimulate human PBMCs proinflammatory cytokine secretion	SPF Meeting 2019 Sociedade Portuguesa de Farmacologia (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021/09/01 - Current	Lactobionic acid-modified polylactic acid nanoparticles as a vaccine adjuvant delivery system Co-supervisor
2022/09/01 - 2023/10/16	The immunomodulatory potential of a dual TLR agonist strategy as a vaccine adjuvant Co-supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2019/02/27 - 2019/02/27	Análise de partículas do Nanómetro ao Milímetro Workshop	Análise de partículas do Nanómetro ao Milímetro Paralab SA, Portugal

Association member

	Society Organization name	Role
2024/01/01 - Current	Sociedade Portuguesa de Imunologia (SPI)
2023/01/01 - Current	Associação Portuguesa de Investigação em Cancro (ASPIC)
2023/01/01 - Current	European Association for Cancer Research (EACR)
2022/01/01 - Current	Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)
2021/05/01 - 2021/12/31	Controlled Release Society (CRS)
2019/03/11 - 2020/03/10	Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL)

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024/04/09 - Current	Lecture on: Glucan-based particle adjuvants as a strategy for an oral vaccine	Nanoparticles & Immune System (Doutoramento)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Distinctions

Award

2021	Bolsa de Investigação APEF/MSD 2021 Associação Portuguesa para o Estudo do Fígado, Portugal
2019	TRANSVAC2/ ENOVA Adjuvant and Vaccine Formulation Training School Studentship European Network on Vaccine Adjuvants (ENOVA), United Kingdom
2018	FCT individual PhD studentship (SFRH/BD/139142/2018) Fundação para a Ciência e a Tecnologia, Portugal

Title

2019	Accreditation as Investigator for scientific experimentation involving animals (FELASA category B, certified by DGAV, Portugal) Direcção-Geral de Alimentação e Veterinária, Portugal, Portugal