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Ana Rita Bezerra (ARB) concluded her PhD in Biology, specialization of Molecular Biology and Genetics in 2013 (Department of Biology, University of Aveiro-UA). She used Candida albicans as a model system to engineer the first artificial genetic code alteration in any organism. This work had major implications to the field of synthetic biology by opening the possibility of engineering microorganisms with novel phenotypic traits, useful for basic and applied research. As a Post-doc, she integrated the Sybaris FP7-HEALTH European project (2013). This consortium led by Dr. Misha Kapushesky (EMBL-EBI) investigated the genetic basis of susceptibility to fungal disease. From 2014 to 2016, she was a Post-doc in the Mistral European project led by Dr. Philippe Pierre (Centre d’Immunologie de Marseille) and Dr. Manuel Santos (UA). Here, she studied the consequences of mistranslation in immunity and stress resistance of Candida. During this period, she also established a strict collaboration with Dr. Csaba Pál (Synthetic and Systems Biology Unit of Szeged) to reassess links between protein synthesis, stress response, genome diversification, and adaptation potential. During both projects ARB established a network of international collaborators whose expertise range from fungal biology, functional genomics, bioinformatics, systems biology, and immunology. In 2017, ARB integrated the newly created iBiMED (Institute of Biomedicine, UA) as a Researcher at the Medical Mycology laboratory. During 2018-2019, she was awarded a 200.000 euros project (FCT-PTDC /IMI-MIC/5350/2014) as Principal Investigator to unravel the role of mistranslation in the acquisition of drug resistance in C. albicans. During 2021-2025, she was awarded a 250.000 euros project (PTDC/BIA-MIC/1141/2021) and an Assistant Researcher contract (2022.07484.CEECIND) to identify new genetic markers of antifungal resistance using an integrative approach, combining population genomics, genome wide association studies (GWAS) and expression quantitative trait loci (eQTL) mapping. As of 2025, ARB is an Assistant Researcher and Leader at the Medical Mycology Group. In the last 5 years, she partaken in national and international research projects, conference presentations, jury panels of academic degrees and grant attributions, and helped in the organization of conferences. Her leadership skills are echoed in the supervision of 9 MSc thesis and supervision of 4 PhD thesis. Additionally, she acquired teaching experience in the BSc degree of Biomedical Sciences and MsC degree of Clinical Bioinformatics at UA. She participated in scientific dissemination initiatives to scientific and non-scientific audiences, such as the coordination of the medical microbiology program of the Summer School Initiative of the UA. Ana was a member of iBiMED’s volunteer taskforce for the screening of SARS-CoV-2 for COVID-19 diagnosis. She is a member of the Portuguese Association of Medical Mycology (ASPOMM).
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Identification

Personal identification

Full name
Ana Rita Macedo Bezerra

Citation names

  • Bezerra, Ana R.
  • Bezerra, A.R.

Author identifiers

Ciência ID
D51F-435D-14EB
ORCID iD
0000-0003-4613-1711

Email addresses

  • armbezerra@ua.pt (Professional)

Addresses

  • Health Sciences Department - University of Aveiro. Campus Universitário de Santiago, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Genetics and Heredity

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/09/01 - 2013/02/27
Concluded
 Biologia (Doutoramento)
Major in Biologia Molecular e Genética
Universidade de Aveiro, Portugal
"Molecular Genomics of a Genetic Code Alteration" (THESIS/DISSERTATION)
 Aprovado
2002/09/01 - 2007/07/19
Concluded
 Biologia (Licenciatura)
Universidade de Aveiro, Portugal
"The role of Glutathione in the tolerance of isolate E20-8 of Rhizobium leguminosarum to different heavy metals" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2023/08/01 - Current Auxiliary Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro, Portugal
2019/01/01 - 2023/07/31 Contracted Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2016/12/01 - 2018/12/31 Postdoc (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2013/06/01 - 2016/11/01 Postdoc (Research) Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2012/03/01 - 2013/03/01 Researcher (Research) Universidade de Aveiro Departamento de Biologia, Portugal
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2007/11/01 - 2011/10/01 Researcher (Research) Universidade de Aveiro Departamento de Biologia, Portugal
2006/09/01 - 2007/07/01 Research Trainee (Research) Biocant Associação de Transferência de Tecnologia, Portugal
Biocant Associação de Transferência de Tecnologia, Portugal
Projects

Grant

Designation Funders
2014 - 2018 Unfreezing the genetic code
SFRH/BPD/96741/2013
Post-doc Fellow
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2011 MOLECULAR GENOMICS OF A GENETIC CODE ALTERATION
SFRH/BD/39030/2007
PhD Student Fellow
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/06/01 - 2025/05/30 Finding new genetic markers of antifungal resistance in the fungal pathogen Candida albicans
PTDC/BIA-MIC/1141/2021
Principal investigator
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/01/01 - 2019/12/31 Unravelling the role of mistranslation in the acquisition of drug tolerance and resistance in Candida albicans
grant.Provided by PTCRIS: 143986
PTDC/IMI-MIC/5350/2014
Principal investigator
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2013 - 2016 Consequences of reciprocal control of mistranslation during antifungal immunity
FCT-ANR/IMI-MIC/0041/2012
Post-doc Fellow
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
 Agence nationale de la recherche

Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2013 Functional genomics of ribosome infidelity phenotypes associated to human diseases
PTDC/SAU-GMG/098850/2008
Research Fellow
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 SYBARIS - Finding Biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system
FP7-HEALTH-2009 - Project ID: 242220
Research Fellow
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development Health
Concluded
2007 - 2012 Reversion of a genetic code alteration in the human pathogen Candida albicans
PTDC/BIA-MIC/099826/2008
PhD Student Fellow
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2007 Estudo das leveduras vínicas da Bairrada
42/01/05/FDR/00126
Scientific Initiation Fellow
Biocant Associação de Transferência de Tecnologia, Portugal
 Biocant Associação de Transferência de Tecnologia
Concluded

Other

Designation Funders
2018/01/01 - 2021/12/31 Identification and quantification of protein biosynthesis errors at the proteome scale
PTDC/BIA-MIB/31238/2017
Researcher
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2021/08/31 CANCYL: Exploring the genome of the emergent pathogenic fungus, Candida rugosa
PTDC/BIA-MIC/31849/2017
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Bezerra, Ana R.. "Identification and characterization of the grape and wine microorganisms from the bairrada appellation". Paper presented in Symposium of Enology of Bordeaux - OENO2017, Bordeaux, 2007.
Conference poster
  1. Bezerra, A.R.. "Genetic and phenotypic diversity of commensal and clinical Candida albicans isolates". Paper presented in VII iBiMED Symposium – Sharing Science, Inspiring Progress, 2024.
  2. Bezerra, A.R.. "A proteogenomic pipeline for the analysis of protein biosynthesis errors in the human pathogen Candida albicans". Paper presented in RNA Biology in Host-Pathogen Interactions, an Epiviral Conference, 2024.
  3. Bezerra, A.R.. "The effect of Endoplasmic Reticulum stress on STING response". Paper presented in 17th International Symposium on Dendritic Cells,, 2024.
  4. Bezerra, A.R.. "The role of non-standard translation in the adaptation of Candida albicans to antifungal drugs". Paper presented in VI iBiMED Symposium – From fundamental research to clinical practice, 2023.
  5. Bezerra, A.R.. "Tracking the emergence of resistance: DNA and RNA sequencing of in vitro evolved isolates of Candida albicans". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023.
  6. Carvalho,M.J.; Pinheiro,M.M.; Reis,A.; Bezerra, A.R.; Santos,M.A.S.; Moura,G.R.. "Unveiling the genome of Limtongozyma cylindracea". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022.
  7. Bezerra, A.R.. "Tackling the emerging threat of fungal infections and antifungal resistance to human health". Paper presented in iBiMED Scientific Advisory Board (SAB) visit, 2022.
  8. Carvalho,M.J.; Silva,C.; Guimaraes,A.R.; Bezerra,A.R.; Reis,A.; Pinheiro,M.M.; Santos,M.; Moura,G.R.. "Paving the way for genomic surveillance, phylogenomics and overall characterisation of Candida sp. isolates". Paper presented in GenomePT Symposium, 2021.
  9. Guimarães,A.R.; Pinheiro,M.M.; Reis,A.; Bezerra,A.R.; Santos,M.. "Adaptation to codon reassignment induces major genomic and transcriptomic alterations in S. cerevisiae". Paper presented in GenomePT Symposium, 2021.
  10. Sousa,G.; Guimarães,A.R.; Pinheiro,M.M.; Oliveira,C.; Moura,G.R.; Santos,M.; Bezerra,A.R.. "Unraveling the genetic basis of drug resistance in mistranslating Candida albicans strains". Paper presented in GenomePT Symposium, 2021.
  11. Guimarães, A.R.; Bezerra, Ana R.; Santos, M.A.S.. "Reassigning the Saccharomyces cerevisiae genome through codon ambiguities and evolution". Paper presented in xliii Jornadas Portuguesas de Genética, 2020.
  12. Brinco, C; Oliveira, C; Guimarães, A.R.; Santos, M.A.S.; Bezerra, Ana R.. "Mistranslation potentiates antifungal drug tolerance in Candida albicans". Paper presented in Molecular FEBS Course on Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens, 2019.
  13. Brinco, C; Oliveira, C; Guimarães, A.R.; Santos, M.A.S.; Bezerra, Ana R.. "The role of mistranslation in the acquisition of drug tolerance and resistance in Candida albicans". Paper presented in Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems, 2018.
  14. Oliveira, C; Santos, M.A.S.; Bezerra, Ana R.. "The role of protein mistranslation in fungal pathogenesis". Paper presented in V Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2018.
  15. Coimbra, R; Pinheiro, M; Reis, A; Bezerra, Ana R.; Santos, M.A.S.; Moura, G. "The impact of a codon reassignment event on the evolution of the yeast C. cylindracea". Paper presented in IV Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2018.
  16. Lopes, E.; Bezerra, Ana R.; Santos, M.A.S.. "Identification of regulators of mistranslation in Candida albicans". Paper presented in IV Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2018.
  17. Coimbra, R.; Reis, A.; Bezerra, Ana R.; Moura, G. "Unveiling the Candida rugosa transcriptome through next-generation sequencing". Paper presented in XLI Jornadas Portuguesas de Genética, 2017.
  18. Oliveira, C.; Guimarães, A.R.; Rocha, S.; Santos, M.A.S.; Bezerra, Ana R.. "Morphogenetic changes are modulated by mistranslation in the human pathogen Candida albicans". Paper presented in III Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2017.
  19. Lopes, E.; Oliveira, C; Bezerra, Ana R.; Santos, M.A.S.. "Identification of molecules and pathways regulating mistranslation in Candida albicans". Paper presented in XLI Jornadas Portuguesas de Genética, 2017.
  20. Bezerra, Ana R.; Kalapis, D.; Szamecz, B.; Gut, I.; Santos, M.A.S.; Pál, C.. "Studying evolutionary adaptation to erroneous protein synthesis". Paper presented in III Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2017.
  21. Bezerra, Ana R.; Oliveira, C; Santos, M.A.S.. "The role of mistranslation in the yeast-to-hyphal transition of C. albicans cells". Paper presented in FEBS Course on Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence, 2017.
  22. Bezerra, Ana R.; Kalapis, D.; Szamecz, B.; Santos, M.A.S.; Pál, C.. "Evolution of adaptation to protein aggregation in Saccharomyces cerevisiae". Paper presented in Ciência 2016, 2016.
  23. Bezerra, Ana R.; Tomásio, R; Moura, G; Rocha, S; Santos, M.A.S.. "Unravelling the role of mistranslation in the pathogenesis of Candida albicans". Paper presented in II Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro, 2016.
  24. Bezerra, Ana R.; Kalapis, D.; Szamecz, B.; Santos, M.A.S.; Pál, C.. "Evolution of adaptation to protein aggregation in Saccharomyces cerevisiae". Paper presented in Research Day, 2016.
  25. Bezerra, Ana R.; Lopes, E.; Santos, M.A.S.. "Identification of the regulatory networks that control expression of the SerRS and LeuRS in Candida albicans". Paper presented in 10th International symposium on aminoacyl-tRNA synthetases, 2015.
  26. Bezerra, Ana R.; Kalapis, D.; Szamecz, B.; Bayés, M.; Santos, M.A.S.; Pál, C.. "Evolution of robustness to protein mistranslation by accelerated protein turnover". Paper presented in 27th International Conference on Yeast Genetics and Molecular Biology, 2015.
  27. Ragionieri, L; Bezerra, Ana R.; Luc-Soucier, J; Santos, M.A.S.; Moura, G. "Elucidating the role of translational machinery on gene evolution using Saccharomycotina subphylum". Paper presented in EMBO Conference Series - From Functional Genomics to Systems Biology, 2014.
  28. Bezerra, Ana R.; Simões, J; Santos, M.A.S.. "Proteomic and metabolic analysis of mistranslating Candida albicans strains". Paper presented in Gene translation: fidelity and quality control conference, 2013.
  29. Bezerra, Ana R.; Simões, J; Santos, M.A.S.. "Systems biology of Candida albicans mistranslation". Paper presented in XXXVIII Jornadas Portuguesas de Genética, 2013.
  30. Simões, J.; Bezerra, Ana R.; Weil, T.. "The Candida albicans proteome tolerates generalized genetic code ambiguity". Paper presented in XXIV tRNA Conference, 2012.
  31. Bezerra, Ana R.; Simões, J.; Weil, T.; Gut, I.; Bayés, M.; Kapusheski, M.; Santos, M.A.S.. "Reversion of a genetic code alteration generates genetic and phenotypic diversity in Candida albicans". Paper presented in EMBO Conference Series on Experimental Approaches to Evolution & Ecology, 2012.
  32. Weil, T.; Bezerra, Ana R.; Simões, J.; Santos, M.A.S.. "Genetic code ambiguity accelerates evolution of drug resistance in Candida albicans". Paper presented in FINSysB Conference: Candida Infection Biology – fungal armoury, battlefields and host defences, 2011.
  33. Bezerra, Ana R.; Simões, J.; Weil, T.; Santos, M.A.S.. "Molecular characterization of Candida albicans strains with a standard genetic code". Paper presented in Third FEBS Course on Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence, 2011.
  34. Bezerra, Ana R.; Simões, J.; Weil, T.; Santos, M.A.S.. "The enginneering of a genetic code alteration". Paper presented in EMBO Meeting, 2010.
  35. Bezerra, Ana R.; Simões, J.; Weil, T.; Moura, G; Santos, M.A.S.. "Reversion of a genetic code alteration in the human pathogen Candida albicans". Paper presented in Yeast Genetics and Molecular Biology Meeting, 2010.
  36. Simões, J.; Bezerra, Ana R.; Rocha, R.; Pouplana, L.R.; Santos, M.A.S.. "Threshold and regulation of the genetic code ambiguity in Candida albicans". Paper presented in 10th ASM Conference on Candida and Candidiasis, 2010.
  37. Bezerra, Ana R.; Simões, J.; Weil, T.; Santos, M.A.S.. "Reversion of a genetic code alteration in the human pathogen Candida albicans". Paper presented in 23rd tRNA workshop: from the origin of life to biomedicine, 2010.
  38. Bezerra, Ana R.; Simões, J.; Santos, M.A.S.. "New tools for studying the Candida albicans genetic code". Paper presented in Third FEBS Course on Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence, 2009.
Journal article
  1. Correia, Inês; Oliveira, Carla; Reis, Andreia; Guimarães, Ana Rita; Aveiro, Susana; Domingues, Pedro; Bezerra, Ana Rita; et al. "A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans". Molecular & Cellular Proteomics 23 9 (2024): 100818. https://doi.org/10.1016/j.mcpro.2024.100818.
    10.1016/j.mcpro.2024.100818
  2. Oliveira, C.; Guimarães, A.R.; Correia, I.; Sousa, I.; Poim, A.; Rocha, S.M.; Moura, G.; Santos, M.; Bezerra, A.R.. "Filamentation in Candida albicans is modulated by adaptive translation of farnesol signalling genes". mBio (2022):
    Under revision
  3. Bezerra, Ana Rita; Oliveira, Carla; Correia, Inês; Guimarães, Ana Rita; Sousa, Gonçalo; Carvalho, Maria João; Moura, Gabriela; Santos, Manuel A S. "The role of non-standard translation in Candida albicans pathogenesis". FEMS Yeast Research 21 4 (2021): http://dx.doi.org/10.1093/femsyr/foab032.
    10.1093/femsyr/foab032
  4. Guimarães, Ana Rita; Correia, Inês; Sousa, Inês; Oliveira, Carla; Moura, Gabriela; Santos, Manuel A. S.; Bezerra, Ana Rita. Corresponding author: Bezerra, Ana Rita. "tRNAs as a Driving Force of Genome Evolution in Yeast". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.634004.
    Published • 10.3389/fmicb.2021.634004
  5. Costa, Carina Pedrosa; Bezerra, Ana Rita; Almeida, Adelaide; Rocha, Sílvia M.. "Candida Species (Volatile) Metabotyping through Advanced Comprehensive Two-Dimensional Gas Chromatography". Microorganisms 8 12 (2020): 1911. http://dx.doi.org/10.3390/microorganisms8121911.
    Published • 10.3390/microorganisms8121911
  6. Bezerra, Ana. "Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans.". mSphere (2017): http://europepmc.org/abstract/med/28808688.
    Published • 10.1128/msphere.00167-17
  7. Simões, J.; Bezerra, A.R.; Moura, G.R.; Araújo, H.; Gut, I.; Bayes, M.; Santos, M.A.S.. "The fungus Candida albicans tolerates ambiguity at multiple codons". Frontiers in Microbiology 7 MAR (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964334240&partnerID=MN8TOARS.
    Published • 10.3389/fmicb.2016.00401
  8. Bezerra, A.R.; Guimarães, A.R.; Santos, M.A.S.. "Non-standard genetic codes define new concepts for protein engineering". Life 5 4 (2015): 1610-1628. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947051079&partnerID=MN8TOARS.
    Published • 10.3390/life5041610
  9. Bezerra, A.R.; Kalapis, D.; Farkas, Z.; Horvath, P.; Bódi, Z.; Daraba, A.; Szamecz, B.; et al. "Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover". PLoS Biology 13 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949445216&partnerID=MN8TOARS.
    Published • 10.1371/journal.pbio.1002291
  10. Moura, G.R.; Pinheiro, M.; Freitas, A.; Oliveira, J.L.; Frommlet, J.C.; Carreto, L.; Soares, A.R.; Bezerra, A.R.; Santos, M.A.S.. "Erratum: Species-Specific Codon Context Rules Unveil Non-Neutrality Effects of Synonymous Mutations (PLoS ONE (2011) 6:10 (e26817))". PLoS ONE 10 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84956899012&partnerID=MN8TOARS.
    Published • 10.1371/journal.pone.0145593
  11. Bezerra, A.R.; Simões, J.; Lee, W.; Rung, J.; Weil, T.; Gut, I.G.; Gut, M.; et al. "Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification". Proceedings of the National Academy of Sciences of the United States of America 110 27 (2013): 11079-11084. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879727622&partnerID=MN8TOARS.
    Published • 10.1073/pnas.1302094110
  12. Soares, A.R.; Pereira, P.M.; Ferreira, V.; Reverendo, M.; Simóes, J.; Bezerra, A.R.; Moura, G.R.; Santos, M.A.S.. "Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos". Toxicological Sciences 127 1 (2012): 18-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860179523&partnerID=MN8TOARS.
    Published • 10.1093/toxsci/kfs068
  13. Paredes, J.A.; Carreto, L.; Simões, J.; Bezerra, A.R.; Gomes, A.C.; Santamaria, R.; Kapushesky, M.; Moura, G.R.; Santos, M.A.S.. "Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast". BMC Biology 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862338006&partnerID=MN8TOARS.
    Published • 10.1186/1741-7007-10-55
  14. Soares, A.R.; Reverendo, M.; Pereira, P.M.; Nivelles, O.; Pendeville, H.; Bezerra, A.R.; Moura, G.R.; Struman, I.; Santos, M.A.S.. "Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862690378&partnerID=MN8TOARS.
    Published • 10.1371/journal.pone.0039417
  15. Moura, G.R.; Pinheiro, M.; Freitas, A.; Oliveira, J.L.; Frommlet, J.C.; Carreto, L.; Soares, A.R.; Bezerra, A.R.; Santos, M.A.S.. "Species-specific codon context rules unveil non-neutrality effects of synonymous mutations". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055031054&partnerID=MN8TOARS.
    Published • 10.1371/journal.pone.0026817
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 Experimental Evolution of Yeast Lacking tRNA-Modifying Enzymes and its consequences on transcriptome VII iBiMED Symposium – Sharing Science, Inspiring Progress
(Aveiro, Portugal)
2024 Genetic diversity of commensal and clinical Candida albicans isolates XXII Jornadas de Biologia de Leveduras Professor Nicolau van Uden
(Curia, Portugal)
2024 Genomic insights into antifungal resistance in commensal and clinical isolates of Candida albicans iBiMED Scientific Advisory Board Visit
(Ílhavo, Portugal)
2023/05/26 Genomic insights into multidrug-resistance and host adaptation in Candida spp. isolates from patients with candidiasis. VI iBiMED Symposium: from fundamental research to clinical practice
iBiMED/DCM, University of Aveiro (Aveiro, Portugal)
2023/01/28 Mapping antifungal drug resistance in human fungal pathogens by genomic approaches Symposium “What can wide molecular analyses (‘OMICS’) do for us?”
iBiMED/DCM, University of Aveiro (Aveiro, Portugal)
2023 Non-standard translation accelerates the evolution of azole resistance and induces major genomic alterations in Candida albicans Research Summit UA
(Aveiro, Portugal)
2023 Experimental Evolution of Yeast Strains Lacking tRNA-Modifying Enzymes Induces Major Genome Rearrangements IV International Meeting of the Portuguese Society of Genetics
(Braga, Portugal)
2023 Experimental evolution and dynamics of adaptation of yeast lacking tRNA-modifying enzymes RNA Modifications in Health and Disease
(Banff, Canada)
2022/06/27 Unraveling the genetic basis of drug resistance in Candida albicans strains with non-standard translation III International Meeting of the Portuguese Society of Genetics
(Évora, Portugal)
2022/02 Clinical and biomedical study of fungal infections and antifungal resistance Medisis Open Day
Aveiro, Portugal
2021/05 One bioinformatics pipeline for genomic characterisation of Candida sp. clinical strains X Bionformatics Open Days
Virtual Event
2020/09 Molecular diagnosis and protocols for pathogen screening International COVID-19 Webinar: current scenario, opportunities and challenges
(Virtual Event)
2019/05 Protein mistranslation modulates hyphal initiation in Candida albicans Molecular FEBS Course on Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens
(Nice, France)
2018/10 Re-coding the Saccharomyces cerevisiae genome through evolution Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems
(Heidelberg, Germany)
2018/09 Re-coding the Saccharomyces cerevisiae genome through codon ambiguities 27th tRNA Conference
(Strarsbourg, France)
2017/07 Evolution of robustness to protein mistranslation XLI Jornadas Portuguesas de Genética
(Aveiro, Portugal)
2017/07 The role of mistranslation in the yeast-to-hyphal transition of C. albicans cells Ciência 2017
(Lisboa, Portugal)
2015/10 Evolution of robustness to protein mistranslation in yeast 10th International symposium on aminoacyl-tRNA synthetases
(Barcelona, Spain)
2015/06 Multi-omics approach to understand Candida albicans mistranslation x-Chroma Workshop: Utilizing metabolomics to understand complex systems
(Aveiro, Portugal)
2015/06 Evolution of robustness to protein mistranslation by accelerated protein turnover I Simpósio de Pós-Graduação em Biomedicina da Universidade de Aveiro
(Aveiro, Portugal)
2013/12 Genetic code engineering generates genetic and phenotypic diversity in the human pathogen Candida albicans XXIV tRNA Conference
(Olmué, Chile)
2012/10 Reversion of a genetic code alteration generates genetic and phenotypic diversity in Candida albicans EMBO Conference Series on Experimental Approaches to Evolution & Ecology
(Heidelberg, Germany)
2012/05 Genetic code engineering generates genetic and phenotypic diversity in the human pathogen Candida albicans XXXVII Jornadas Portuguesas de Genética
(Lisboa, Portugal)
2012/03 Molecular characterization of Candida albicans strains with a standard genetic code Society for General Microbiology Spring Conference
(Dublin, Ireland)
2011/05 Molecular characterization of Candida albicans strains with a standard genetic code Third FEBS Course on Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence
(Nice, France)
2010/12 Effects of translational stress mutagenesis on the evolution of antifungal drug resistance XVII Congresso Nacional de Bioquímica
(Porto, Portugal)
2010/03 Reversion of CUG Identity from Serine to Leucine in Candida albicans 10th ASM Conference on Candida and Candidiasis
(Miami, United States)
2010/02 Reversion of a genetic code alteration in the human pathogen Candida albicans 23rd tRNA workshop: from the origin of life to biomedicine
(Aveiro, Portugal)
2009/04 Partial reversion of CUG identity in Candida albicans VIII Simpósio de Pós-Graduação do Departamento de Biologia da Universidade de Aveiro
(Aveiro, Portugal)
2007/06 Desenvolvimento de uma ferramenta laboratorial para a monitorização da população microbiológica durante a fermentação de mostos XV Jornadas das Leveduras Prof. Nicolau Van Uden
(Porto, Portugal)
2007/06 Identification and characterization of the grape and wine microorganisms from the bairrada appellation, in Portugal, using an Enochip OENO2007
(Bordeaux, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Genetic markers of antifungal resistance in Candida species
Supervisor
 Molecular Biomedicine (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2024 - Current Candidiasis: identifying novel RNA-based factors as virulence determinants in Candida albicans clinical isolates
Co-supervisor
 Master in Molecular and Cell Biology (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2024 - Current Translation errors as drivers of antifungal resistance in clinical settings
Supervisor
 Applied Biology (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2024 - Current Fast and accurate clinically-relevant variant detection in fungal pathogens
Co-supervisor
 Molecular and Cell Biology (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2022 - Current Unraveling the genetic basis of drug resistance in Candida albicans strains with non-standard translation
Supervisor of Gonçalo Giesta de Sousa
Biomedicine (PhD)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2021 - Current Elucidating the role of tRNA-modifications in human diseases
Co-supervisor
 Biomedicine (PhD)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2017 - Current The role of protein mistranslation in fungal pathogenesis
Co-supervisor of Carla Brites de Oliveira
 Biomedicine (PhD)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2023 - 2024 Unraveling the phenotypic and genetic diversity among clinical isolates of the human fungal pathogen Candida albicans
Supervisor
 Microbiology (Master)
Universidade de Aveiro, Portugal
2016 - 2023 Re-coding the Saccharomyces cerevisiae genome through codon ambiguities
Co-supervisor of Ana Rita Guimarães da Silva
 Biomedicine (PhD)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2020 - 2021 Mapping antifungal drug resistance in fungal pathogens by genomic approaches
Supervisor
 Molecular Biomedicine (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2019 - 2021 Biomedical and clinical characterization of recurrent vulvovaginal infections
Co-supervisor
 Molecular Biomedicine (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2019 - 2019 Preconcentration of DNA using magnetic ionic liquids that are compatible with PCR: case study of Candida albicans
Co-supervisor of Ângela Sofia Moreira Marques
 Biotechnology (Scientific initiation)
Universidade de Aveiro Departamento de Química, Portugal
2018 - 2019 The role of mistranslation in the acquisition of antifungal resistance
Supervisor of Matilde de Almeida Figueiredo
 Molecular Biomedicine (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2017 - 2018 The role of mistranslation in the acquisition of drug tolerance and resistance in Candida albicans
Supervisor of Catarina Brinco
 Molecular Biomedicine (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2016 - 2017 Single cell variation in mistranslation rates of the human pathogen Candida albicans
Supervisor of Rosana Tomásio
 Molecular and cell biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2014 - 2015 Identification of molecules and pathways regulating mistranslation in Candida albicans
Supervisor of Carla Brites de Oliveira
 Molecular and cell biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2013 - 2014 Evolution of antifungal drug resistance in Candida albicans
Supervisor of Mónica Rodrigues Barbosa
Molecular and cell biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2013 - 2014 Codon ambiguities as a mechanism to alter the genetic code in Saccharomyces cerevisiae
Supervisor of Ana Rita Guimarães da Silva
 Molecular and cell biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2010 - 2011 mRNA mistranslation in Saccharomyces cerevisiae
Co-supervisor of Jorge Fernando Ferreira de Sousa Paulo
Molecular and cell biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2010 - 2011 Mistranslation in Candida albicans
Co-supervisor of Diana Sofia Ortiga de Sousa
Molecular and cellular biology (Master)
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/06/08 - 2017/06/09 XLI Jornadas Portuguesas de Genética (2017/06/08 - 2017/06/09)
Conference (Member of the Organising Committee)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2017/06/07 - 2017/06/07 III Simpósio de Pós-Graduação em Biomedicina (2017/06/07 - 2017/06/07)
Symposium (Member of the Organising Committee)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2010/01/28 - 2010/02/02 23rd tRNA workshop: from the origin of life to biomedicine (2010/01/28 - 2010/02/02)
Congress (Co-organisor)
 Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015 - Current UA Summer School - Coordination of the Medical Microbiology program
Workshop
 UA Summer School - Coordination of the Medical Microbiology program
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - 2022 European Researchers' Night
Exhibition
 European Researchers' Night
2019/10/10 - 2019/10/12 Techdays - Showing of technology belonging to the Department of Medical Sciences
Exhibition
 Techdays
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/04/29 - 2019/04/30 Xperimenta UA - Workshops, visits, science shows, experiences and field trips
Exhibition
 Xperimenta UA - Workshops, visits, science shows, experiences and field trips
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018 - 2018 UA Open Campus - Workshops, visits, science shows, experiences and field trips
Exhibition
 UA Open Campus - Workshops, visits, science shows, experiences and field trips

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Influence of iron and glucose availability and hormesis on autophagy and chronological life in Saccharomyces cerevisiae
(Thesis) Arguer
 Sandra Montellá-Manuel (PhD)
Universitat de Lleida, Spain
2024 Unravelling the roles of proteotoxic stress on genome diversification and disease
(Thesis) Arguer
 Inês Sousa (PhD)
Universidade de Aveiro, Portugal
2024 Personalized medicine in Candidiasis: relevance of automating laboratory workflow
(Thesis) Main arguer
 Stephanie Holum (Master)
Universidade de Aveiro, Portugal
2022 Characterisation of Candida albicans isolates from distinct clinical human samples and the clinical environment
(Thesis) Main arguer
 Filipa Sampaio (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2021 Mapping antifungal drug resistance in fungal pathogens by genomic approaches
Supervisor
 Gonçalo Filipe Giesta de Sousa (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/12/16 Chemokines effect on kinases and phosphatases involved in AD pathology
President of the jury
 Margarida Isabel Nascimento Vaz (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 The role of mistranslation in the acquisition of antifungal resistance
Supervisor
 Matilde Figueiredo (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2018 The role of mistranslation in the acquisition of drug tolerance and resistance in Candida albicans
Supervisor
 Catarina Brinco (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2016 Identification of molecules and pathways regulating mistranslation in Candida albicans
Supervisor
 Carla Oliveira (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2015 Codon ambiguities as a mechanism to alter the genetic code in Saccharomyces cerevisiae
Supervisor
 Ana Rita Guimarães (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2015 Evolution of antifungal drug resistance in Candida albicans
Supervisor
 Mónica Barbosa (Master)
Universidade de Aveiro Departamento de Biologia, Portugal

Association member

Society Organization name Role
2022 - Current Portuguese Society of Medical Mycology Member
2009 - 2012 Portuguese Biochemistry Society Member
2007 - 2009 Portuguese Biology Society Member

Committee member

Activity description
Role 		Institution / Organization
2022 - Current PhD monitoring committee - Biomedicine
Member
 Universidade de Aveiro, Portugal
2022 - 2022 Electoral Commission for the General council of the Medical Sciences Department, University of Aveiro
Member
 Universidade de Aveiro, Portugal
2022 - 2022 Poster evaluation - Masters Day, Department of Medical Sciences, University of Aveiro
Member
 Universidade de Aveiro, Portugal
2017 - 2017 Electoral Commission for the General council of the Medical Sciences Department, University of Aveiro
Member
 Universidade de Aveiro, Portugal

Conference scientific committee

Conference name Conference host
2024 - 2024 VII iBiMED Symposium: Sharing Science, Inspiring Progress

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - 2025 Genetics and Epigenetics Bioinformática Clínica (Mestrado) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2025 Program based learning – Functional and Organic Systems I Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2025 Program based learning – Functional and Organic Systems IV Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018 - 2019 Práticas de Biotecnologia Clínica I Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2017 - 2019 Program based learning – Functional and Organic Systems II Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2017 - 2019 Program based learning – From the Molecule to the Man II Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2017 - 2018 RNA Biology Seminars Biologia (Mestrado integrado) Universidade de Aveiro Departamento de Biologia, Portugal
2016 - 2017 Program based learning – Functional and Organic Systems III Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2016 - 2017 Biopatologia I Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Microorganisms (2076-2607) MDPI
2020 - Current Frontiers in Microbiology (1664-302X) Frontiers Media
2016 - Current Molecular Biology and Evolution (1537-1719) Oxford University Press

Mentoring / Tutoring

Topic Student name
2022 - 2022 Antifungal drug resistance Mafalda Castro
2017 - 2017 Medical microbiology Maria Brandão
2013 - 2013 Medical microbiology Rui Miguel Esteves de Campos Monteiro

Other jury / evaluation

Activity description Institution / Organization
2023 - 2023 Member of the selection jury. Type of grant: First stage researcher (R1) Reference: Varcal - 2022.01376.PTDC Scientific Area: Biomedicine – Medical Biotechnology Universidade de Aveiro Instituto de Biomedicina, Portugal
2021 - 2021 Member of the selection jury. Type of grant: Masters Reference: PTDC/BTM-TEC/29843/2017 Scientific Area: Biomedicine – Medical Biotechnology Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2019 Member of the selection jury. Type of grant: Masters Reference: PTDC/BEX-BCM/2121/2014 Scientific Area: Medical Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2017 - 2017 Member of the selection jury. Type of grant: Masters Reference: MEDPERSYST­MESTRE Scientific Area: Biological Sciences and Human Genomics Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2017 - 2017 Member of the selection jury. Type of grant: Masters Reference: PTDC/BIM-MEC/1719/2014 Scientific Area: Biological Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2016 - 2016 Member of the selection jury. Type of grant: Masters Reference: PTDC/BEX-BCM/2121/2014 Scientific Area: Medical Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2016 - 2016 President of the selection jury. Type of grant: Masters Reference: PTDC/IMI­MIC/5350/2014 Scientific Area: Biological Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2016 - 2016 Member of the selection jury. Type of grant: Masters Reference: PTDC/BIM-MEC/1719/2014 Scientific Area: Biological Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
Distinctions

Award

2015 Award for Best Poster presentation - "Identification of the regulatory networks that control expression of the SerRS and LeuRS in Candida albicans"
Institut de Recerca Biomèdica, Spain
2014 Award for Best Poster presentation - “Systems biology of Candida albicans mistranslation”
Universidade de Aveiro, Portugal
2011 Young Investigator Award for a Workshop Talk - "Molecular characterization of Candida albicans strains with a standard genetic code"
Institut Pasteur, France