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Identification

Personal identification

Full name
Nuno Martinho

Citation names

  • Martinho, Nuno

Author identifiers

Ciência ID
D51E-5772-FF5F

Email addresses

  • nunomartinho@tecnico.ulisboa.pt (Professional)

Addresses

  • Institute for Bioengineering and Biosciences, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Engineering and Technology - Nano-technology
  • Exact Sciences - Chemical Sciences - Polymer Science
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2022/03
Concluded
Pedagogical Skills for Teaching Assistants (Outros)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/06/30 - 2021/07/03
Concluded
Manipulation and analysis of gene expression (Outros)
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2020
Concluded
Laboratory Animals Science (Category B) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018
Concluded
Pharmaceutical Technology (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin: from design and synthesis to platinum-membrane interactions" (THESIS/DISSERTATION)
2012
Concluded
Master in Pharmaceutical Sciences (Mestrado)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Drug delivery systems of NO-donors for oral administration" (THESIS/DISSERTATION)
16
2012
Concluded
Basic Concepts of Cell Culture (Pós-Graduação)
Grupo Lusófona, Portugal
Affiliation

Science

Category
Host institution
Employer
2021 - 2022 Contracted Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2018/12/15 - 2020/06/14 Contracted Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Projects

Grant

Designation Funders
2022 - Current Using a Genetic Algorithm to design new urease inhibitors
CPCA/A1/407814/2021
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - Current Urease Next-Generation inhibition Therapy
PTDC/MED-QUI/3542/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
2018 - 2021 Exploring the biophysical link between Gaucher disease and Parkinson’s diseas
PTDC/BIA-BFS/29448/2017
Integration into Research Grant Fellow

Contract

Designation Funders
2018/12/15 - 2020/06/15 Dendrimer-based Report-Eradication Antineoplasic Machines
PTDC/MEC-ONC/29327/2017
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Martinho, Nuno; Mire Zloh. "Modelling Approaches for Studies of Drug-Polymer Interactions in Drug Delivery Systems". In Computer Aided Pharmaceutics and Drug Delivery. Springer Singapore, 2022.
  2. Silva, Catarina Oliveira; Martinho, Nuno; Aniceto, Natália; Catarina Pinto Reis. "Melanoma Prevention: Challenges and Progresses in Nanotechnology for Melanoma Prevention and Treatment". In CRC Concise Encyclopedia of Nanotechnology, 477-494. CRC Press, 2016.
    10.1201/b19457-41
  3. Reis, Catarina; Martinho, Nuno; Damgé, Christiane. "Nanotechnology for Oral Drug Delivery and Targeting". In Nanotechnology and Drug Delivery, Volume Two, 20-51. CRC Press, 2016.
    10.1201/b19976-3
  4. Martinho, Nuno; Helena F Florindo; Ana Ester Ventura; Tânia Santos; Ana Carreira; João Conniot; Ana Raquel Varela; Rogério Gaspar. "Drugs, delivery systems and membrane organization in model and cell membranes". In Membrane organization and lipid rafts in the cell and artificial membranes. 2016.
Conference poster
  1. Ledesma-Martin, V; Assis, D; Martinho, Nuno; Aniceto, N; Decker, M; Guedes, R. "Structure and ligand-based strategies to discover novel orexin receptor modulators: targeting the circadian clock and Alzheimer’s disease". Paper presented in 15th National Organic Chemistry Meeting, 2024.
  2. Assis, D; Ledesma-Martin, V; Martinho, Nuno; Guedes, R. "Revolution in Neuroscience: Innovating Alzheimer's Treatment with Photoswitchable Molecules". 2024.
  3. Dalila Mil-Homens; Laura Pereira; Rita F. Pires; José M. Andrade; Marta M. Alves; Gabriel Serafim; Martinho, Nuno; et al. "Biocompatible Engineered polyurea (PURE) dendrimers are a new hope against multidrug-resistant (MDR) bacteria". Paper presented in Microbiotec 23, 2023.
  4. Martinho, Nuno; Joaquim M. T. Marquês; Rodrigo F. M. Almeida; Vasco V. B. Bonifácio; Liana C Silva. "Polyurea (PURE) dendrimers as modulators of membrane permeability to enhance cisplatin delivery". Paper presented in InnovDelivery22, 2022.
  5. Martinho, Nuno; Mire Zloh; Rita F. Pires; Bonifácio, Vasco D. B.. "In silico characterization of PURE dendrimers-small molecules interactions". Paper presented in 11th International Dendrimer Symposium (IDS11), 2019.
  6. Martinho, Nuno; Liana C Silva; Helena Florindo; S. Brocchini; Mire Zloh; Teresa Barata. "Conformational behavior of poly(L-glutamic acid) dendrimers bearing different fluorophores and their interactions with membranes". Paper presented in APS UKPharmSci Conference, 2014.
  7. Martinho, Nuno; Liana C Silva; Helena Florindo; Brocchini, S.; Mire Zloh; Barata, Teresa. "In silico generation of a peptide dendrimer with different fluorophores and their interaction with a lipid bilayer model". Paper presented in EMBL-EBI/Wellcome Trust Workshop: Resources for Computational Drug Discovery, 2014.
  8. Martinho, Nuno; Philippe Maincent; Pinto Reis, Catarina; Gibaud, Stéphane. "Synthesis and characterization of S-nitroso-oligo-chitosan as NO-donor". Paper presented in Nano2013.pt, 2013.
  9. Martinho, Nuno; Barata, Teresa; Brocchini, S.; Silva, Liana C.; Helana Florindo; Mire Zloh. "Automated in silico approach to generate 3D poly(glutamic) acid dendrimers". Paper presented in 2nd EPSRC CIM in Emergent Macromolecular Therapies Annual Research Event, 2013.
  10. Martinho, Nuno; Brocchini, S.; Teresa Barata; Florindo, Helena; Silva, Liana C.; Vanessa Sainz; Mire Zloh. "A molecular Modelling Approach to the design and optimization of poly(glutamic acid) (PG) dendrimers as drug delivery vehicles". Paper presented in 2nd EPSRC CIM in emergen Macromolecular Therapies – Annual Research Event, 2013.
  11. Martinho, Nuno; Rosado, Catarina; Fernandes, Ana S.; Pinto Reis, Catarina. "Design of PLGA nanoparticles containing Azelaic Acid for Acne Treatment". Paper presented in Colloids and Nanomedicine, 2012.
  12. Martinho, Nuno; Rosado, Catarina; Pinto Reis, Catarina. "Application of new drug delivery systems in encapsulation of lipophilic drugs for transdermal use". Paper presented in III Congresso Nacional de Ciêncas Dermacosméticas, 2011.
  13. Martinho, Nuno; Pinto Reis, Catarina; Rosado, Catarina. "Design and permeation studies of Alginate multiparticulate systems for transdermal drug delivery". Paper presented in 12th Annual Meeting of Skin Forum, 2011.
  14. Martinho, Nuno; Rosado, Catarina; Silva, Catarina; Pinto Reis, Catarina. "Pre-formulation study: selection of a method for production of PLGA nanoparticles for later encapsulation of azelaic acid". Paper presented in Nano2011.pt, 2011.
  15. Martinho, Nuno; Rosado, Catarina; Pinto Reis, Catarina. "Development and optimization process of PLGA nanoparticles obtained by m-SESD method". Paper presented in Nano2011.pt, 2011.
  16. Martinho, Nuno; Rosado, Catarina; Silva, Catarina; Pinto Reis, Catarina. "Development of azelaic-acid PLGA nanoparticles by m-SESD method for topical treatment of acne". Paper presented in Nano2011.pt, 2011.
  17. Martinho, Nuno; Rosado, Catarina; Pinto Reis, Catarina. "Development of alginate beads and microparticles loaded with ibuprofen for transdermal delivery". Paper presented in IV Congresso Ibero-Americano de Ciências Farmacêuticas, 2011.
  18. Martinho, Nuno. "Avaliação comparativa da informação sobre medicamentos antidepressivos na intervenção em Cuidados Farmacêuticos". Paper presented in GICUF, 2009.
Journal article
  1. Gosecki, Mateusz; Urbaniak, Malgorzata; Martinho, Nuno; Gosecka, Monika; Zloh, Mire. "Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation". Molecules 28 21 (2023): 7308. http://dx.doi.org/10.3390/molecules28217308.
    10.3390/molecules28217308
  2. Aniceto, Natália; Albuquerque, Tânia S.; Bonifácio, Vasco D. B.; Guedes, Rita C.; Martinho, Nuno. "Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening". International Journal of Molecular Sciences 24 9 (2023): 8180. http://dx.doi.org/10.3390/ijms24098180.
    10.3390/ijms24098180
  3. Martinho, Nuno; Marquês, Joaquim M. T.; Todoriko, Iryna; Prieto, Manuel; de Almeida, Rodrigo F.M.; Silva, Liana C.. "Effect of Cisplatin and Its Cationic Analogues in the Phase Behavior and Permeability of Model Lipid Bilayers". Molecular Pharmaceutics (2023): http://dx.doi.org/10.1021/acs.molpharmaceut.2c00321.
    10.1021/acs.molpharmaceut.2c00321
  4. Aniceto, Natália; Bonifácio, Vasco D. B.; Guedes, Rita C.; Martinho, Nuno. "Exploring the Chemical Space of Urease Inhibitors to Extract Meaningful Trends and Drivers of Activity". Journal of Chemical Information and Modeling (2022): http://dx.doi.org/10.1021/acs.jcim.2c00150.
    10.1021/acs.jcim.2c00150
  5. Pinto, Sandra; Mil-Homens, Dalila; Pires, Rita; Alves, Marta M.; Serafim, Gabriel; Martinho, Nuno; Melo, Manuel; Fialho, Arsénio Mendes; Bonifácio, Vasco D.B.. "Core-shell polycationic polyurea pharmadendrimers: New-generation of sustainable broad-spectrum antibiotics and antifungals". Biomaterials Science (2022): http://dx.doi.org/10.1039/d2bm00679k.
    10.1039/d2bm00679k
  6. Martinho, Nuno; Pires, Rita F.; Zloh, Mire; Bonifácio, Vasco D. B.. "Intrinsic acetamide brush-off by polyurea biodendrimers". Journal of Materials Chemistry B 9 15 (2021): 3371-3376. http://dx.doi.org/10.1039/d1tb00105a.
    10.1039/d1tb00105a
  7. Martinho, Nuno; Santos, Tânia C. B.; Florindo, Helena F.; Silva, Liana C.. "Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity". Frontiers in Physiology 9 (2019): http://dx.doi.org/10.3389/fphys.2018.01898.
    10.3389/fphys.2018.01898
  8. Martinho, Nuno; Silva, Liana; Florindo, Helena; Brocchini, Steve; Zloh, Mire; Barata, Teresa. "Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties". International Journal of Nanomedicine Volume 12 (2017): 7053-7073. http://dx.doi.org/10.2147/ijn.s135475.
    10.2147/ijn.s135475
  9. Martinho, Nuno; Silva, Liana C.; Florindo, Helena F.; Brocchini, Steve; Barata, Teresa; Zloh, Mire. "Practical computational toolkits for dendrimers and dendrons structure design". Journal of Computer-Aided Molecular Design 31 9 (2017): 817-827. http://dx.doi.org/10.1007/s10822-017-0041-6.
    10.1007/s10822-017-0041-6
  10. Moura, L. I. F.; Martinho, N.; Silva, L. C.; Barata, T. S.; Brocchini, S.; Florindo, H. F.; Zloh, M.. "Poly-glutamic dendrimer-based conjugates for cancer vaccination – a computational design for targeted delivery of antigens". Journal of Drug Targeting 25 9-10 (2017): 873-880. http://dx.doi.org/10.1080/1061186x.2017.1363213.
    10.1080/1061186x.2017.1363213
  11. Teresa Barata; Liane Moura; Martinho, Nuno (D51E-5772-FF5F); Helena F Florindo; Mire Zloh. "Computational design of a novel poly-glutamic dendrimer-based platform as an anticancer therapeutic approach". Febs Journal (2016):
  12. Shah, Shefaat Ullah; Martinho, Nuno; Socha, Marie; Pinto Reis, Catarina; Gibaud, Stéphane. "Synthesis and characterization ofS-nitrosoglutathione-oligosaccharide-chitosan as a nitric oxide donor". Expert Opinion on Drug Delivery 12 8 (2015): 1209-1223. http://dx.doi.org/10.1517/17425247.2015.1028916.
    10.1517/17425247.2015.1028916
  13. Martinho, Nuno; Florindo, Helena; Silva, Liana; Brocchini, Steve; Zloh, Mire; Barata, Teresa. "Molecular Modeling to Study Dendrimers for Biomedical Applications". Molecules 19 12 (2014): 20424-20467. http://dx.doi.org/10.3390/molecules191220424.
    10.3390/molecules191220424
  14. Catarina Pinto Reis; João Pinto Ferreira; Sara Candeias; Cátia Fernandes; Nuno Martinho; Natália Aniceto; António Silvério Cabrita; Isabel V. Figueiredo. "Ibuprofen Nanoparticles for Oral Delivery: Proof of Concept". Journal of Nanomedicine & Biotherapeutic Discovery 04 01 (2014): http://dx.doi.org/10.4172/2155-983x.1000119.
    10.4172/2155-983x.1000119
  15. Gomes, A.; Ascensão, L.; Rijo, P.; Baptista, M.; Candeias, S.; Martinho, N.; Fernandes, A.; Roberto, A.; Reis, C.. "Evaluation of a New Topical Treatment for Acne with Azelaic Acid-Loaded Nanoparticles". Microscopy and Microanalysis 19 S4 (2013): 59-60. http://dx.doi.org/10.1017/s1431927613000913.
    10.1017/s1431927613000913
  16. Reis, Catarina Pinto; Gomes, Ana; Rijo, Patrícia; Candeias, Sara; Pinto, Pedro; Baptista, Marina; Martinho, Nuno; Ascensão, Lia. "Development and Evaluation of a Novel Topical Treatment for Acne with Azelaic Acid-Loaded Nanoparticles". Microscopy and Microanalysis 19 05 (2013): 1141-1150. http://dx.doi.org/10.1017/s1431927613000536.
    10.1017/s1431927613000536
  17. Reis, Catarina Pinto; Martinho, Nuno; Rosado, Catarina; Fernandes, Ana S.; Roberto, Amílcar. "Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment". Drug Development and Industrial Pharmacy 40 3 (2013): 409-417. http://dx.doi.org/10.3109/03639045.2013.767826.
    10.3109/03639045.2013.767826
  18. Pinto Reis, Catarina; Silva, Catarina; Martinho, Nuno; Rosado, Catarina. "Drug carriers for oral delivery of peptides and proteins: accomplishments and future perspectives". Therapeutic Delivery 4 2 (2013): 251-265. http://dx.doi.org/10.4155/tde.12.143.
    10.4155/tde.12.143
  19. Martinho, Nuno; Rosado, Catarina; Reis, Catarina Pinto. "Influência de duas técnicas diferentes no tamanho e potencial zeta de nanopartículas de poli(D.L-láctico-co-glicólico)". (2013): http://hdl.handle.net/10437/3675.
  20. Martinho, Nuno; Rosado, Catarina; Pinto Reis, Catarina. "The influence of two different techniques on the particle size and zeta potencial of poly (D,L-Lactide-co-glycolide) nanoparticles". Journal Biomedical and Biopharmaceutical Research 8 2 (2011): 329-338. http://dx.doi.org/10.19277/bbr.8.2.21.
    10.19277/bbr.8.2.21
  21. Martinho, Nuno; Damgé, Christiane; Reis, Catarina Pinto. "Recent Advances in Drug Delivery Systems". Journal of Biomaterials and Nanobiotechnology 02 05 (2011): 510-526. http://dx.doi.org/10.4236/jbnb.2011.225062.
    10.4236/jbnb.2011.225062
Thesis / Dissertation
  1. Martinho, Nuno. "Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin : from design and synthesis to platinum-membrane interactions". PhD, 2018. http://hdl.handle.net/10451/35238.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09 Journey to the Chemical Frontier of Urease Inhibition: molecular design guided by machine learning I International meeting: Molecules 4 Life
2022 Engineered polyurea (PURE) dendrimers are a potential alternative to conventional antibiotics Asiapacificbiofilms
2019/07/29 Insights from molecular modeling and dynamics into dendrimers as drug delivery carriers Seminar at itqb
(Portugal)
2012 Design of azelaic-acid loaded PLGA nanoparticles for topical delivery XX BRG Annual International Conference on Bioencapsulation
(Canada)
2011/11/14 Citicoline drug penetration across the blood barrier for treatment of mental diseases Angelini University Award
(Portugal)

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023 ChemSlotProtein: Expanding the druggable universe to unlock chemists´creativity
(Thesis) Arguer
Ismael Rufino de Carvalho (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 Development of a new integrated system for the treatment of chronic kidney disease: Synergetic combination of a nano-drug delivery system and membrane technology
(Thesis) Main arguer
Pedro Rodrigues Nunes Paulo de Almeida (Master)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2022/12/28 Analysis of PI(4,5)P2 organization at the plasma membrane of living cells through a combinations of FRET and FRAP Pedro Bulcão (Master)
2022 Avaliação in vitro do potencial terapêutico de novos compostos contra a tuberculose INÊS ALEXANDRA BOTELHO PORTO CUNHA E SILVA ANTUNES (Other)
2021/11 Towards nanostructured membranes for the artificial kidney
(Thesis) Main arguer
Madalena Pereira Bonifácio Lopes (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 Advanced dendrimers for capture and storage of sustainable energy
Thesis Member
Rita Figueiredo Pires (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

Society Organization name Role
2011 - 2012 REFlexus magazine Contributer to editorial team

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - Current From lab to jab: basic concepts of nano drug delivery systems
2022/01/26 - 2022/01/26 From lab to jab: basic concepts of nano drug delivery systems Biologia Molecular (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal

Mentoring / Tutoring

Topic Student name
2022 - 2023 Targeting cytoplasmic lipid droplets for therapeutic and imaging applications Elodie Delavictoire
2022/09 - 2022/10 Virtual Screening of polyurea dendrimers as metalloenzyme inhibitors Ana Clara Rodrigues
2022 - 2022 Green synthesis and in vitro performance of novel urease inhibitors Tânia Albuquerque
2022 - 2022 Manufacture of biopolymers via mechanochemistry Marta Brandão
2021 - 2022 Design, synthesis and in vitro test of novel urease inhibitors Inês Azevedo
2019 - 2020 Insights into the killing mechanism of biomimetic antimicrobial polymers using MD simulations Gabriel Serafim
Distinctions

Award

2013 Merit Scholarship
2013 Student Merit
Ordem dos Farmaceuticos, Portugal

Other distinction

2022 Review Editor of Technological and Methodological Advances in Drug Delivery
2020 Guest Editor of Polymers (MDPI) for issue on Polyureas
Multidisciplinary Digital Publishing Institute AG, Switzerland
2012 Merit Scholarship
2012 ERASMUS scholarship
European Commission, Belgium
2011 Merit Scholarship
2009 Merit Scholarship