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Identification

Personal identification

Full name
CÂNDIDA SUSANA GONÇALVES DA SILVA

Author identifiers

Ciência ID
D513-D305-7FD1
ORCID iD
0000-0002-7092-1169
Education
Degree Classification
2010/04/27
Concluded
 Doutoramento em Química (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004/06/29
Concluded
 Pós-graduação em Bioinformática (Diploma de especialização)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16
2003/12/23
Concluded
 Licenciatura em Matemática e Ciências da Computação (Licenciatura)
Universidade do Minho, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
2014/12/01 - 2015/04/23 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/01 - 2014/11/30 Science and Technology Management Universidade de Coimbra Centro de Química de Coimbra, Portugal
2010/09/01 - 2013/12/31 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/02/01 - 2010/07 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/03/17 - 2003/11/30 Researcher (Research) Universidade do Minho, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2018/09/14 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
2016/04 - 2018/07/31 Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
2011/09 - 2013/07 Invited Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Química, Portugal
2002/09 - 2003/02 Tutor (University Teacher) Universidade do Minho Departamento de Matemática e Aplicações, Portugal
2001/09 - 2002/02 Tutor (University Teacher) Universidade do Minho Departamento de Matemática e Aplicações, Portugal
Projects

Grant

Designation Funders
2019/06 - 2021 Plataforma móvel de promoção da atividade física em pessoas com DPOC nos Cuidados de Saúde Primários.
Bolsa de Investigação – Update em Medicina / Alfasigma
Researcher
Center for Innovative Care and Health Technology, Portugal
 Alfasigma Portugal LDA
Concluded
2019/06 - 2021 Plataforma móvel de promoção da atividade física em pessoas com DPOC nos Cuidados de Saúde Primários.
Bolsa de Investigação Update em Medicina / Alfasigma
 Alfasigma Portugal LDA
2010/09/01 - 2013/12/31 Ibercivis.pt – Uma plataforma de computação voluntária para a Península Ibérica
UMIC
Post-doc Fellow
Concluded
2007/06 - 2010/12 P-found: GRID computing and distributed data warehousing of protein folding and unfolding simulations
Provided by PTCRIS: 81809
81809
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2020 - Current Gym2BeKind – Academia do Conhecimento
Gym2BeKind
Researcher
Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
2012/03 - 2015/02 Fibrils, Interrupted: Inhibiting Deviant Protein-Protein Interactions in Amyloids
Provided by PTCRIS: 122900
122900
Post-doc
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2010/12 Searching for high level rules in protein folding and unfolding: from amyloid diseases to protein structure prediction
Provided by PTCRIS: 72838
72838
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2003/03/17 - 2003/11/30 Information Knowledge and Fusion
Projecto Eureka!2235
Scientific Initiation Fellow

Other

Designation Funders
2018/12 - Current OnTRACK – On Time to Rethink ACtivity Knowledge: A personalized mHealth coaching platform to tackle physical inactivity in COPD
POCI-01-0145-FEDER- 028446
Researcher
Ongoing
2019 - 2022 PAIRAR – Processo Assistencial Integrado Articulado
PAIRAR
Researcher
Center for Innovative Care and Health Technology, Portugal
Concluded
2020 - 2021 Nível de Satisfação dos utentes da unidade de saúde funcional de Porto de Mós
Ur'Gente
Principal investigator
Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
Concluded
2016 - 2019/12 Unraveling the Rules of Passive Permeation Through the Blood-Brain Barrier
PT2020-PTDC/DTP-FTO/2784/2014,
Researcher
Ongoing
Outputs

Publications

Book
  1. Camacho, R.; Alves, A.; Silva, C.G.; Brito, R.M.M.. On mining protein unfolding simulation data with inductive logic programming. 2009.
    10.1007/978-3-540-85861-4_21
  2. Ferreira, P.G.; Silva, C.G.; Azevedo, P.J.; Brito, R.M.M.. Spatial clustering of molecular dynamics trajectories in protein unfolding simulations. 2009.
    10.1007/978-3-642-02504-4_14
  3. Fernandes, E.; Jorge, A.M.; Silva, C.G.; Brito, R.M.. A knowledge discovery method for the characterization of protein unfolding processes. 2009.
    10.1007/978-3-540-85861-4_22
  4. Silva, C.G.; Ferreira, P.G.; Azevedo, P.J.; Brito, R.M.M.. Using data mining techniques to probe the role of hydrophobic residues in protein folding and unfolding simulations. 2009.
    10.4018/978-1-60566-816-1.ch012
  5. Swain, M.; Ostropytskyy, V.; Silva, C.G.; Stahl, F.; Riche, O.; Brito, R.M.M.; Dubitzky, W.. Grid computing solutions for distributed repositories of protein folding and unfolding simulations. 2008.
    10.1007/978-3-540-69389-5_10
  6. Ferreira, P.G.; Azevedo, P.J.; Silva, C.G.; Brito, R.M.M.. Mining approximate motifs in time series. 2006.
  7. Azevedo, P.J.; Silva, C.G.; Rodrigues, J.R.; Loureiro-Ferreira, N.; Brito, R.M.M.. Detection of hydrophobic clusters in molecular dynamics protein unfolding simulations using association rules. 2005.
Book chapter
  1. "Using data mining techniques to probe the role of hydrophobic residues in protein folding and unfolding simulations". In Evolving application domains of data warehousing and mining: Trends and Solutions. Information Science Reference, 2009.
    Published
Conference abstract
  1. Pimenta, Sara; Flora, Sofia; Silva, Cândida G.; Oliveira, Ana; Morais, Nuno; Ribeiro, José; Silva, Fernando; et al. "Motivation and physical activity in COPD: an exploratory study". 2021.
    10.1183/13993003.congress-2021.pa1816
  2. Vieira, Ana; Dias, Diana; Miguel, Eunice; Matos, Telma; Flora, Sofia; Silva, Cândida G.; Morais, Nuno; et al. "Relationship between fatigue, physical activity and health-related factors in COPD". 2021.
    Published • 10.1183/13993003.congress-2021.pa336
  3. "The usefulness of serum inflammatory biomarkers to predict anastomotic leakage after colorectal surgery: systematic review and meta-analysis". Paper presented in LXI Congresso Nacional de Cirurgia, 2021.
  4. Araújo Oliveira, Ana Luisa; Flora, Sofia; Santos, Liliana; Morais, Nuno; Ribeiro, Jose; Silva, Fernando; Silva, Candida; et al. "Characteristics of patients with COPD using mobile apps in daily life". 2020.
    10.1183/13993003.congress-2020.4109
  5. "Early anastomotic leak diagnosis after colorectal surgery: preliminary results from prospective observational study". Paper presented in LXI Congresso Nacional de Cirurgia, 2020.
    Published
  6. "Implementation of AGILiIdades’ protocol in people with Alzheimer’s disease at home -– 2 study cases monitored by caregivers". Paper presented in Congresso Internacional Cuidados de Saúde Centrados nas Pessoas, 2019.
  7. Cordeiro Da Costa, João; Viana, Raquel; Gonçalves Silva, Cândida; Carvalho, Cláudia; Feijó, Salvato. "Pseudomonas aeruginosa as an independent predictor of decreased lung function in bronchiectasis". 2019.
    10.1183/13993003.congress-2019.pa2871
  8. Cordeiro Da Costa, João; Viana, Raquel; Gonçalves Silva, Cândida; Feijó, Salvato. "Bronchiectasis Severity Index and FACED score correlation determinants". 2019.
    10.1183/13993003.congress-2019.pa2867
  9. Hipólito, Nádia; Ruivo, Adriana; Martins, Sara; Flora, Sofia; Marques, Alda; Brooks, Dina; Silva, Cândida G.; Januário, Filipa; Cruz, Joana. "Relationship between distress and physical activity in informal carers of patients with COPD". 2019.
    10.1183/13993003.congress-2019.pa1245
  10. Brites, Luisa; Santiago, Mariana; Rovisco, João; Freitas, João Dinis de; Da Silva, José Antonio P.; Silva, Inês; Teixeira, Filipa; et al. "AB1127 ULTRASOUND INTER-READER RELIABILITY OF INFLAMMATORY FINDINGS IN PATIENTS WITH POLYARTHRITIS". 2019.
    10.1136/annrheumdis-2019-eular.2181
  11. "Relação entre a Atividade Física e o Distress Associado à Sobrecarga em Cuidadores Informais de Indivíduos com DPOC.". Paper presented in Between2Lungs – Actualização da Fisioterapia Cardiorrespiratória, 2018.
    Published
  12. "O tratamento do aneurisma da aorta abdominal em octogenários: Qual o papel da cirurgia convencional?". Paper presented in XVII Congresso da Sociedade Portuguesa de Angiologia e Cirurgia Vascular, 2017.
    Published
  13. "Cell Spotting: Avaliação da motivação e resultados educacionais da participação num projecto de ciência cidadã na sala de aula". Paper presented in SciCom Pt 2016 – 4º Congresso de Comunicação de Ciência, 2016.
  14. "Searching for Novel Inhibitors of Transthyretin Amyloid with the Volunteer Computing Platform Ibercivis". Paper presented in 2º Encontro Nacional de Química Terapêutica, 2010.
Conference paper
  1. Ferreira, P.G.; Silva, C.G.; Brito, R.M.M.; Azevedo, P.J.. "A closer look on protein unfolding simulations through hierarchical clustering". 2007.
  2. "A Closer Look on Protein Unfolding Simulations through Hierarchical Clustering". Paper presented in 2007 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB’07, 2007.
    Published
  3. Silva, C.G.; Ostropytskyy, V.; Loureiro-Ferreira, N.; Berrar, D.; Swain, M.; Dubitzky, W.; Brito, R.M.M.. "P-found: The protein folding and unfolding simulation repository". 2006.
    10.1109/CIBCB.2006.330978
  4. Stahl, F.; Berrar, D.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Grid warehousing of molecular dynamics protein unfolding data". 2005.
    10.1109/CCGRID.2005.1558594
Conference poster
  1. "Relação entre a Fadiga e a Atividade Física na DPOC". Paper presented in XI Congresso Nacional de Fisioterapeutas, 2021.
  2. "Perfil de atividade física de pessoas com Doença Pulmonar Obstrutiva Crónica (DPOC) em Portugal". Paper presented in XI Congresso Nacional de Fisioterapeutas, 2021.
  3. "Motivos para a Prática de Atividade Física e Atividade Física Atual em pessoas com DPOC". Paper presented in XI Congresso Nacional de Fisioterapeutas, 2021.
  4. "Efeito de um programa de tiro com zarabatana na função respiratória de adultos com Dificuldades Intelectuais e Desenvolvimentais". Paper presented in XI Congresso Nacional de Fisioterapeutas, 2021.
  5. "Saúde Vocal a Marchar". Paper presented in 2nd International Congress of Health and Well-being Intervention, 2021.
  6. "Implementing a personalized mHealth coaching platform to tackle physical inactivity in COPD – the OnTRACK project (Poster)". Paper presented in 24th WONCA European Conference, 2019.
  7. "Validity and reliability of the QASCI questionnaire to assess caregiving burden in COPD". Paper presented in 4th Congress of CiiEM on “Health, Well-Being and Ageing in the 21st Century, 2019.
  8. "Estudo das alterações metabólicas post mortem no fígado por espectroscopia de RMN". Paper presented in VII Congresso Luso-Brasileiro de Patologia Experimental, 2017.
  9. "Characterization of the ß2m-ThT complex using molecular dynamics and alchemical free energy calculations". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional e Estrutural, 2015.
  10. "Application of Molecular Dynamics and Alchemical Free Energy Calculations to study the interaction of ß-2 microglobulin with thioflavin-T". Paper presented in Congresso Química Orgânica e Química Terapêutica – 4º Encontro Nacional de Química Terapêutica, 2015.
  11. "Searching for structural determinants in amyloid recognition and binding". Paper presented in 6th European Conference Chemistry in the Life Sciences, 2015.
  12. "Searching for new probes for amyloid". Paper presented in Segundo Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2014.
  13. "Molecular docking and molecular dynamics studies of the interaction of ThT with ß2-microglobulin". Paper presented in XVIII Congresso da Sociedade Portuguesa de Bioquímica, 2014.
  14. "Virtual Screening in the discovery of the 5a-reductase potential inhibitors". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional e Estrutural, 2013.
  15. "Searching for Strategies to Improve the discrimination between Active and Inactive Compounds in Virtual Screening: COX-1 as a case study". Paper presented in X Encontro Anual do Centro de Neurociências e Biologia Celular, 2012.
  16. "A Strategy to Improve the Discrimination between Ligands and Decoys in Virtual Screening: COX-1 as a case study". Paper presented in 3º Encontro Nacional de Química Terapêutica, 2012.
  17. "Prognostic factors in acute cholangitis: a 1-year retrospective analysis". Paper presented in 20th United European Gastroenterology Week, 2012.
  18. "Data Mining Strategies for the Analysis of Protein Folding and Unfolding Simulation Data". Paper presented in Bioinformatics Open Days, 2012.
  19. "Risk factors and complications of endoscopic polypectomy: a prospective study". Paper presented in 20th United European Gastroenterology Week, 2012.
  20. "Fighting Amyloid at Home: the search for novel drug candidates against FAP with the help of volunteer citizens and the Ibercivis platform". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  21. "Application of data mining techniques to molecular dynamics protein unfolding simulations". Paper presented in I Forum Português em Biologia Computacional, 2008.
  22. "Probing the conformational pathways leading to Transthyretin amyloidosis: insights from multiple molecular dynamics unfolding simulations". Paper presented in IACB06 – VI Ibero-American Congress of Biophysic, 2006.
Journal article
  1. Pedro Machado; Miguel Morgado; João Raposo; Marco Mendes; Cândida G. Silva; Nuno Morais. "Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials". Supportive Care in Cancer (2022): https://doi.org/10.1007/s00520-022-06856-3.
    10.1007/s00520-022-06856-3
  2. Sara Pimenta; Cândida G. Silva; Sofia Flora; Nádia Hipólito; Chris Burtin; Ana Oliveira; Nuno Morais; et al. "What Motivates Patients with COPD to Be Physically Active? A Cross-Sectional Study". Journal of Clinical Medicine (2021): https://doi.org/10.3390/jcm10235631.
    10.3390/jcm10235631
  3. Flora, Sofia; Hipólito, Nádia; Brooks, Dina; Marques, Alda; Morais, Nuno; Silva, Cândida G.; Silva, Fernando; et al. "Phenotyping Adopters of Mobile Applications Among Patients With COPD: A Cross-Sectional Study". Frontiers in Rehabilitation Sciences 2 (2021): http://dx.doi.org/10.3389/fresc.2021.729237.
    Open access • Published • 10.3389/fresc.2021.729237
  4. Hipólito, Nádia; Ruivo, Adriana; Martins, Sara; Flora, Sofia; Marques, Alda; Brooks, Dina; Silva, Cândida G.; Januário, Filipa; Cruz, Joana. "Reliability and validity of the QASCI questionnaire to assess caregiving burden in COPD". Annals of Medicine 53 sup1 (2021): S85-S86. http://dx.doi.org/10.1080/07853890.2021.1897441.
    10.1080/07853890.2021.1897441
  5. "Exploring the Relationship between Socioemotional Skills and Decision-Making Styles in Health Students". IAFOR Journal of Education 9 5 (2021): 49. http://dx.doi.org/10.22492/ije.9.5.
    Open access • Published
  6. "Anastomotic Leak in Colorectal Cancer Surgery: From Diagnosis to Management or Failure - A Retrospective Cohort Study". Surg. Gastroenterol. Oncol. 26 3 (2021): 183-190. http://dx.doi.org/10.21614/sgo-26-3-336.
    Published
  7. "Associação entre a velocidade da marcha e a participação social em pessoas com esclerose múltipla: uma revisão sistemática". Revista Salutis Scientia 1 (2021): 1-16.
    Open access • Published
  8. Rosa, Marlene Neves; Amorim, Andreia; Bartolo, Marisa; Martins, Ana Rita; Oliveira, Catarina; Silva, Cândida. "Avaliação do impacto das abordagens bottom-up e top-down nas atividades da vida diária em pessoas com neglect – revisão sistemática". Revista Pesquisa em Fisioterapia 10 4 (2020): 785-808. http://dx.doi.org/10.17267/2238-2704rpf.v10i4.3323.
    Open access • Published • 10.17267/2238-2704rpf.v10i4.3323
  9. Nádia Hipólito; Adriana Ruivo; Sara Martins; Beatriz Dinis; Sofia Flora; Alda Marques; Dina Brooks; et al. "Relationship between Distress Related to Caregiver Burden and Physical Activity in Informal Caregivers of Patients with COPD". COPD: Journal of Chronic Obstructive Pulmonary Disease (2020): 1-6. https://doi.org/10.1080/15412555.2020.1799964.
    10.1080/15412555.2020.1799964
  10. Silva, Cândida G.. "Ultrasonography Reliability in the Detection of Inflammatory and Structural Abnormalities". JCR: Journal of Clinical Rheumatology (2020): http://dx.doi.org/10.1097/rhu.0000000000001440.
    10.1097/rhu.0000000000001440
  11. Parente, Diana Silva; Rama, Nuno; Sales, Inês; Neves, Miguel; Sousa, Inês; Gonçalves, Inês; Gil, Inês; et al. "Failure to Rescue in Colorectal Surgery: Why Looking Back?". European Journal of Surgical Oncology 46 2 (2020): e93. http://dx.doi.org/10.1016/j.ejso.2019.11.226.
    10.1016/j.ejso.2019.11.226
  12. "Prosthetic Vascular Graft Infection — Still An Entity To Fear?". Revista Angiologia e Cirurgia Vascular 16 2 (2020): 71-78.
    Open access • Published
  13. "Comparação das curvas de excursão de glucose em resposta à ingestão de uma refeição padrão mista ou prova de tolerância à glucose oral numa população pré-diabética vs grupo controlo". Revista Portuguesa de Diabetes 15 1 (2020): 31.
    Published
  14. Silva, Cândida G.. "Relationship between the perceived social support and catastrophization in individuals with chronic knee pain". Brazilian Journal Of Pain (2019): http://dx.doi.org/10.5935/2595-0118.20190011.
    10.5935/2595-0118.20190011
  15. "Ultrasound inter-reader reliability of inflammatory findings in patients with polyarthritis.". Acta Reumatol. Port. 44 Sup (2019): 53-54.
  16. Jorge, Miguel; Garrido, Nuno M.; Simões, Carlos J. V.; Silva, Cândida G.; Brito, Rui M. M.. "Predicting hydrophobic solvation by molecular simulation: 1. Testing united-atom alkane models". Journal of Computational Chemistry 38 6 (2016): 346-358. http://dx.doi.org/10.1002/jcc.24690.
    10.1002/jcc.24690
  17. "Enhancing scoring performance of docking-based virtual screening through machine learning". Current Bioinformatics 11 (2016):
    Published
  18. "Cell Spotting: Educational and Motivational Outcomes of Cell Biology Citizen Science Project in the Classroom". Journal of Science Communication 15 1 (2016): A02.
    Open access • Published
  19. "SOCIENTIZE participatory experiments, dissemination and networking activities in perspective". Human Computation 1 2 (2014): 119-135.
    Open access • Published
  20. "Fatores de prognóstico na colangite aguda". GE J Port Gastrenterol 19 Espec. Con (2012): 2-3.
  21. "Avaliação prospetiva de complicações pós-polipectomia". GE J Port Gastrenterol 19 Espec Cong (2012): 25.
  22. Rodrigues, J.R.; Simões, C.J.V.; Silva, C.G.; Brito, R.M.M.. "Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations". Protein Science 19 2 (2010): 202-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749161776&partnerID=MN8TOARS.
    10.1002/pro.289
  23. Swain, M.; Silva, C.G.; Loureiro-Ferreira, N.; Ostropytskyy, V.; Brito, J.; Riche, O.; Stahl, F.; Dubitzky, W.; Brito, R.M.M.. "P-found: Grid-enabling distributed repositories of protein folding and unfolding simulations for data mining". Future Generation Computer Systems 26 3 (2010): 424-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449533843&partnerID=MN8TOARS.
    10.1016/j.future.2009.08.008
  24. "P-found GRID: A global resource for protein folding and unfolding simulations". Protein Sci. 17 Supp 1 (2008): 94.
    Open access
  25. Berrar, D.; Stahl, F.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Towards data warehousing and mining of protein unfolding simulation data". Journal of Clinical Monitoring and Computing 19 4-5 (2005): 307-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-30344471278&partnerID=MN8TOARS.
    10.1007/s10877-005-0676-z
Journal issue
  1. "Proceedings of the 4th IPLeiria’s International Health Congress". BMC Health Services Research 18 Sup 2 (2018): https://bmchealthservres.biomedcentral.com/articles/supplements/volume-18-supplement-2.
    Published • Coeditor
Newspaper article
  1. "Ciência – Todos podemos contribuir", Diário de Leiria, 2020, O Conhecimento ao Serviço da Sociedade

Other

Other output
  1. White Paper on Citizen Science for Europe. 2014.
  2. Green Paper on Citizen Science – Citizen Science for Europe: Towards a better society of empowered citizens and enhanced research. 2013.