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My primary research interest is deciphering the intricate molecular and cellular mechanisms that govern the distribution of neuronal cell surface receptors across the neuronal membrane. Additionally, I aim to elucidate the functions of certain neuronal cell surface receptors that remain uncharacterized. Importantly, I aim to address these questions under healthy, aging, and disease conditions. This approach will enable me to understand the mechanisms underlying normal neuronal function and brain wiring, essential for proper brain function, as well as identify novel therapeutic avenues to mitigate the impact of neurological disorders and aging on brain function. During my PhD, completed in September 2013 under the supervision of Prof. Ana Luísa Carvalho at the Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC) in Portugal, I investigated the hippocampal function of ghrelin, an appetite-stimulating hormone, and its receptor. This work was published in PNAS (DOI: 10.1073/pnas.1313798111) and Science Signaling (DOI: 10.1126/scisignal.abb1953), and it gave me a great deal of knowledge on how synapses and neural circuits operate. In May 2014, I joined Prof. Joris de Wit's lab at VIB-KU Leuven Center for Brain & Disease Research in Belgium for my postdoctoral studies. Here, I gained expertise in imaging, biochemical, and proteomic approaches. These methods were instrumental in identifying new molecules and mechanisms involved in regulating synaptic and surface protein composition in neurons. This work was published in Neuron (DOI: 10.1016/j.neuron.2015.08.007) and PLoS Biology (DOI: 10.1371/journal.pbio.3000466). Following my postdoc, I secured funding from the Portuguese Foundation for Science and Technology – FCT (project grant and 6-years’ salary support as an Assistant Investigator – Scientific Employment Stimulus Program) and European Commission (Marie Sklodowska-Curie Action Individual Fellowship – MSCA-IF). These grants enabled me to establish my independent research line at CNC-UC, where I began as an Assistant Investigator in September 2021. Recently, I have been offered an independent Group Leader position at MIA-Portugal, where I will expand my interests in understanding the mechanisms that control the proper distribution of neuronal surface receptors and in unraveling the function of uncharacterized neuronal surface receptors, as well as investigating how this is impacted by brain disorders and aging. Consistent with this plan, I just secured funding from the Chan Zuckerberg Initiative (collaborative pair pilot project award), which will allow me to implement new projects in the lab and to generate new research lines.
Read full resume ↓
Identification

Personal identification

Full name
Luís Filipe Ribeiro
Date of birth
1986/01/24
Gender
Male

Citation names

  • Ribeiro, L. F.
  • Ribeiro, L.

Author identifiers

Ciência ID
D511-9711-807A
ORCID iD
0000-0003-1790-6848
Google Scholar ID
https://scholar.google.com/citations?user=zeMLvEoAAAAJ&hl=pt-PT
Researcher Id
U-3826-2017
Scopus Author Id
49461667600

Email addresses

  • luis.ribeiro@cnc.uc.pt (Professional)

Telephones

Telephone
  • (+351) 304502914 (Professional)

Addresses

  • Rua Larga, Centro de Neurociências e Biologia Celular, Polo 1, Faculdade de Medicina, 2º andar, lab 204, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2009/04/01 - 2013/09/01
Concluded
 PhD in Biology (Cell Biology) (Doutoramento)
Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
"A Link Between Metabolic Signaling and Cognition: The Hippocampal Function of Ghrelin" (THESIS/DISSERTATION)
 Approved with summa cum laude
2007/09/01 - 2008/09/30
Concluded
 Internship of the Bachelor of Science in Biology (Licenciatura)
Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
 19
2004/09/01 - 2008/09
Concluded
 Bachelor of Science in Biology (Licenciatura)
Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
2024/04/01 - Current Principal Investigator (Research) Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021/10/01 - 2024/03/31 Assistant Investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05/01 - 2021/09/30 Postdoctoral Scientist VIB Center for Brain & Disease Research; KU Leuven, Department of Neurosciences, Belgium
2013/10/01 - 2014/04/30 Research Assistant CNC.IBILI, Portugal
2009/04/01 - 2013/09/30 PhD student CNC.IBILI, Portugal
2011/04/01 - 2011/09/30 Visiting PhD student Center of Molecular Biology Severo Ochoa, Spain
2008/10/01 - 2009/03/31 Research Assistant CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2024/04/01 - 2025/09/30 Unraveling Anti-IgLON5 disease-associatedtauopathy with neuroproteomics
CP2-1-0000000126
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 The Chan Zuckerberg Initiative
Ongoing
2021/03/29 - 2025/03/28 Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
10.54499/PTDC/BIA-CEL/2286/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 A New TransSynaptic Bridge: Functional characterization of the NMDA receptor-Neurexin interaction
2022.05386.PTDC
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/10/01 - 2024/03/31 Exploring the dendritic molecular machinery responsible for neuronal polarization
101031398
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Commission
Ongoing
2015/05/01 - 2015/09/30 Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits
659927
Principal investigator
VIB Center for Brain & Disease Research; KU Leuven, Department of Neurosciences, Belgium
 European Commission
Concluded
2010/09/15 - 2013/12/31 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type
PTDC/SAU-NEU/099440/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/10/01 - 2028/09/30 Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization.
2021.03397.CEECIND/CP1656/CT0021
10.54499/2021.03397.CEECIND/CP1656/CT0021
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/08/31 Exploring the role of neuronal sorting in the presynaptic expression of homeostatic plasticity
12N0319N
Post-doc Fellow
VIB Center for Brain & Disease Research; KU Leuven, Department of Neurosciences, Belgium
 Fonds Wetenschappelijk Onderzoek Vlaanderen
Concluded
2015/10/01 - 2018/09/30 Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits
12N0316N
Post-doc Fellow
VIB Center for Brain & Disease Research; KU Leuven, Department of Neurosciences, Belgium
 Fonds Wetenschappelijk Onderzoek Vlaanderen
Concluded
2009/04/01 - 2013/03/31 Modulation of Hippocampal Glutamatergic Synapses by Ghrelin
SFRH/BD/47879/2008
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Ribeiro, L. F.. "Neuroligins induce dendritic outgrowth in an ICAM5-dependent manner". Paper presented in FENS Regional Meeting, 2023.
  2. Ribeiro, L. F.. "Neuroligins induce dendritic outgrowth in an ICAM5-dependent manner". Paper presented in 8th European Synapse Meeting, 2022.
  3. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in CSHL Conference on Molecular Mechanisms of Neuronal Connectivity, 2018.
  4. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in EMBO Workshop on Cell Biology of the Neuron: Polarity, Plasticity and Regeneration, 2017.
  5. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in Departmental Day - VIB Center for Brain & Disease Research, 2017.
  6. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in 10th FENS Forum of Neuroscience, 2016.
  7. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in 7th ISN 2016 Special Conference of Neurochemistry, 2016.
  8. Ribeiro, L. F.. "The Sorting Receptor SorCS1 controls axonal targeting of Neurexin". Paper presented in VIB Seminar, 2015.
  9. Ribeiro, L. F.. "Modulation of Hippocampal Glutamatergic Synapses by Ghrelin". Paper presented in Society for Neuroscience Annual Meeting, 2012.
  10. Ribeiro, L. F.. "Modulation of Hippocampal Glutamatergic Synapses by Ghrelin". Paper presented in International Symposium on Ionotropic Glutamate Receptors, 2012.
  11. Ribeiro, L. F.. "A New Function for the Contactin Associated protein 1, Caspr 1, in the Regulation of GluR1 mRNA Stability". Paper presented in EMBO Conference Series on Protein Synthesis and Translational Control, 2009.
Journal article
  1. Pinto, Maria J; Cottin, Léa; Dingli, Florent; Laigle, Victor; Ribeiro, Luís F; Triller, Antoine; Henderson, Fiona; et al. "Microglial TNFa orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep". The EMBO Journal 42 1 (2022): http://dx.doi.org/10.15252/embj.2022111485.
    Published • 10.15252/embj.2022111485
  2. Konstantoulea, Katerina; Guerreiro, Patricia; Ramakers, Meine; Louros, Nikolaos; Aubrey, Liam D; Houben, Bert; Michiels, Emiel; et al. "Heterotypic Amyloid ß interactions facilitate amyloid assembly and modify amyloid structure". The EMBO Journal 41 2 (2021): http://dx.doi.org/10.15252/embj.2021108591.
    Published • 10.15252/embj.2021108591
  3. Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953.
    Published • 10.1126/scisignal.abb1953
  4. Luís F. Ribeiro; Ben Verpoort; Julie Nys; Kristel M. Vennekens; Keimpe D. Wierda; Joris de Wit. "SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function". PLOS Biology 17 10 (2019): e3000466-e3000466. https://doi.org/10.1371/journal.pbio.3000466.
    10.1371/journal.pbio.3000466
  5. Patel, Abdulsamie M.; Wierda, Keimpe; Thorrez, Lieven; van Putten, Maaike; De Smedt, Jonathan; Ribeiro, Luis; Tricot, Tine; et al. "Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes". Translational Psychiatry 9 1 (2019): http://dx.doi.org/10.1038/s41398-019-0535-1.
    Published • 10.1038/s41398-019-0535-1
  6. Sachse, Sonja M; Lievens, Sam; Ribeiro, Luís F; Dascenco, Dan; Masschaele, Delphine; Horré, Katrien; Misbaer, Anke; et al. "Nuclear import of the DSCAM -cytoplasmic domain drives signaling capable of inhibiting synapse formation". The EMBO Journal 38 6 (2019): http://dx.doi.org/10.15252/embj.201899669.
    10.15252/embj.201899669
  7. Santos, Ana Isabel; Carreira, Bruno Pereira; Izquierdo-Álvarez, Alicia; Ramos, Elena; Lourenço, Ana Sofia; Filipa Santos, Daniela; Morte, Maria Inês; et al. "S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model". Antioxidants & Redox Signaling 28 1 (2018): 15-30. http://dx.doi.org/10.1089/ars.2016.6858.
    10.1089/ars.2016.6858
  8. Ribeiro, L.F.; Verpoort, B.; de Wit, J.. "Trafficking mechanisms of synaptogenic cell adhesion molecules". Molecular and Cellular Neuroscience 91 (2018): 34-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045454630&partnerID=MN8TOARS.
    Published • 10.1016/j.mcn.2018.04.003
  9. Schroeder, A.; Vanderlinden, J.; Vints, K.; Ribeiro, L.F.; Vennekens, K.M.; Gounko, N.V.; Wierda, K.D.; de Wit, J.. "A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity". Neuron 99 2 (2018): 329-344.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049055996&partnerID=MN8TOARS.
    Published • 10.1016/j.neuron.2018.06.026
  10. Ribeiro, Luís F.; de Wit, Joris. "Neuronal Polarity: MAP2 Shifts Secretory Vesicles into High Gear for Long-Haul Transport down the Axon". Neuron 94 2 (2017): 223-225. http://dx.doi.org/10.1016/j.neuron.2017.04.002.
    10.1016/j.neuron.2017.04.002
  11. Savas, Jeffrey N.; Ribeiro, Luís F.; Wierda, Keimpe D.; Wright, Rebecca; DeNardo-Wilke, Laura A.; Rice, Heather C.; Chamma, Ingrid; et al. "The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors". Neuron 87 4 (2015): 764-780. http://dx.doi.org/10.1016/j.neuron.2015.08.007.
    10.1016/j.neuron.2015.08.007
  12. Mele, Miranda; Ribeiro, Luís; Inácio, Ana R.; Wieloch, Tadeusz; Duarte, Carlos B.. "GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia". Neurobiology of Disease 65 (2014): 220-232. http://dx.doi.org/10.1016/j.nbd.2014.01.019.
    Published • 10.1016/j.nbd.2014.01.019
  13. Ribeiro, L. F.; Catarino, T.; Santos, S. D.; Benoist, M.; van Leeuwen, J. F.; Esteban, J. A.; Carvalho, A. L.. "Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus". Proceedings of the National Academy of Sciences 111 1 (2013): E149-E158. http://dx.doi.org/10.1073/pnas.1313798111.
    Published • 10.1073/pnas.1313798111
  14. Catarino, Tatiana; Ribeiro, Luís; Santos, Sandra D.; Carvalho, Ana Luísa. "Regulation of synapse composition by protein acetylation: the role of acetylated cortactin". Journal of Cell Science 126 1 (2012): 149-162. http://dx.doi.org/10.1242/jcs.110742.
    Published • 10.1242/jcs.110742
  15. Santos, Sandra D.; Iuliano, Olga; Ribeiro, Luís; Veran, Julien; Ferreira, Joana S.; Rio, Pedro; Mulle, Christophe; Duarte, Carlos B.; Carvalho, Ana Luísa. "Contactin-associated Protein 1 (Caspr1) Regulates the Traffic and Synaptic Content of a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)-type Glutamate Receptors". Journal of Biological Chemistry 287 9 (2012): 6868-6877. http://dx.doi.org/10.1074/jbc.m111.322909.
    Published • 10.1074/jbc.m111.322909
  16. Ferreira, Joana S.; Rooyakkers, Amanda; She, Kevin; Ribeiro, Luis; Carvalho, Ana Luísa; Craig, Ann Marie. "Activity and Protein Kinase C Regulate Synaptic Accumulation of N-Methyl-d-aspartate (NMDA) Receptors Independently of GluN1 Splice Variant". Journal of Biological Chemistry 286 32 (2011): 28331-28342. http://dx.doi.org/10.1074/jbc.m111.222539.
    Published • 10.1074/jbc.m111.222539
Preprint
  1. Schmidt, Jeannette; Inácio, Ângela; Ferreira, Joana S; Serrenho, Débora; Socodato, Renato; Beltrão, Nuno; Ribeiro, Luís F; et al. "Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission". 2024. http://dx.doi.org/10.1101/2024.02.29.582472.
    10.1101/2024.02.29.582472
Thesis / Dissertation
  1. Ribeiro, L. F.. "A Link Between Metabolic Signaling and Cognition: The Hippocampal Function of Ghrelin". PhD, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 2013.
  2. Ribeiro, L. F.. "A New Function for the Contactin Associated protein 1, Caspr 1, in the Regulation of GluR1 mRNA Stability". Degree, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 2008.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/29 Mechanisms underlying neuronal polarization of neuronal surface receptors and neuronal function DCV talk
Maria Teresa Ferreira (Coimbra, Portugal)
2023/08/23 Neuroligins induce dendritic outgrowth in an ICAM5-dependent manner ESN-ISN 2023 Meeting
Amadi Ihunwo (Porto, Portugal)
2023/06/26 Neuroligins induce dendritic outgrowth in an ICAM5-dependent manner Talk at the 2nd Surfaceome Meeting
Davide Comoletti (Scanno , Italy)
2022/11/04 Endosomal sorting in dendrites maintains neuronal polarity and synaptic function Neurobiology Retreat, i3S
Dr. Matthew Holt (Porto, Portugal)
2021/07/13 The somatodendritic sorting receptor SorCS1 controls axonal targeting of neurexin Seminar at Gulbenkian Science Institute
Dr. Caren Norden (Lisbon, Portugal)
2018/07/02 The Sorting Receptor SorCS1 controls axonal targeting of Neurexin Max-Planck-Post Event organized after the 68th Lindau Nobel Laureate Meeting
Max Planck Institute of Experimental Medicine (Dr. Nils Brose) (Göttingen, Germany)
2018/04/10 The Sorting Receptor SorCS1 controls axonal targeting of Neurexin Seminar at VIB Center for Brain & Disease Research
VIB Center for Brain & Disease Research, KU Leuven (Leuven, Belgium)
2016/06/21 The Sorting Receptor SorCS1 controls axonal targeting of Neurexin Seminar at VIB Center for Brain & Disease Research, KU Leuven
VIB Center for Brain & Disease Research, KU Leuven (Leuven, Belgium)
2014/01/27 Modulation of Hippocampal Glutamatergic Synapses by Ghrelin Seminar at VIB Center for Brain & Disease Research
VIB Center for Brain & Disease Research, KU Leuven (Leuven, Belgium)
2012/12/20 Modulation of Hippocampal Glutamatergic Synapses by Ghrelin Talk at the 10th Annual Meeting of the Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2012/10/11 Modulation of Hippocampal Glutamatergic Synapses by Ghrelin Talk at the 22nd Neuropharmacology Conference
22nd Neuropharmacology Conference (New Orleans , United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/12/01 - Current Lab tech on the FCT project (PTDC/BIA-CEL/2286/2020: Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization)
Supervisor of João Francisco Miranda Machado
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/12/01 - Current Lab tech on the FCT project (PTDC/BIA-CEL/2286/2020: Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization)
Supervisor of Beatriz Pereira Marques
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/01/21 - Current Lab tech on the FCT project (PTDC/BIA-CEL/2286/2020: Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization)
Supervisor of Jeannette Schmidt
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/11/01 - 2026/10/31 Exploring the contribution of homeostatic plasticity mechanisms in the pathogenesis of autism spectrum disorder
Co-supervisor of Maria Luísa Dias Pereira Félix Amado
 PhD degree in Experimental Biology and Biomedicine (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/10/01 - 2025/09/30 Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
Supervisor of Alejandra Nunez Torres
 PhD degree in Experimental Biology and Biomedicine (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/10/01 - 2025/09/30 Dissecting the neuronal function of cell adhesion molecule IgLON5 and the pathological mechanism triggered by anti-IgLON5 antibodies
Supervisor of Beatriz Fernandes de Sousa Ribeiro
 PhD degree in Experimental Biology and Biomedicine (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - 2023/10/31 SORTING ID: Identification of axonal proteins trafficked through dendritic endosomes
Supervisor of João Francisco Miranda Machado
 Mestrado em Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/09/30 Dissecting the neuronal function of IgLON5, an uncharacterized cell adhesion molecule
Supervisor of Beatriz Pereira Marques
 Mestrado em Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/03/07 - 2022/08/31 Lab tech on the FCT project (PTDC/BIA-CEL/2286/2020: Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization)
Supervisor of Alejandra Nunez Torres
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/23 - 2022/07/31 Characterization of the surface and synaptic localization of uncharacterized cell adhesion proteins
Supervisor of Débora Rodrigues
 Biologia (Degree)
Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
2022/02/14 - 2022/07/31 Characterization of the molecular machinery responsible for neuronal polarization
Supervisor of David Teixeira
 Engenharia Biomédica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/09/01 - 2021/05/31 Characterization of new synaptic cell-adhesion interactions involved in synaptic function under physiological and pathogenic conditions
Co-supervisor of Ilkem Kumru
 Master in Biology (Master)
Faculty of Science, KU Leuven, Belgium
2019/09/01 - 2020/06/30 Exploring the role of synaptic cell adhesion proteins on dendritic spine plasticity
Co-supervisor of Cydric Geyskens
 Master of Biomedical Sciences (Master)
Faculty of Medicine, KU Leuven, Belgium
2016/09/01 - 2017/06/30 The sorting receptor SorCS1 controls axonal targeting of Neurexin1a (Ben won the KU Leuven prize of best Biomedical Sciences Master thesis of 2017)
Co-supervisor of Ben Verpoort
 Master of Biomedical Sciences (Master)
Faculty of Medicine, KU Leuven, Belgium
2012/09/01 - 2013/07/31 Effects of ghrelin on hippocampal glutamate receptors and neuronal morphology
Co-supervisor of Joni van Leeuwen
 Master in Cellular and Molecular Biology (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/03/01 - 2010/09/30 Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
Co-supervisor of Olga Iuliano
 Master of Genetics and Molecular Biology (Master)
CNC.IBILI, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/01/01 - Current Organizer of the lunch with speakers initiative at CNC-UC/CIBB. I initiated and have been organizing this initiative at CNC-UC/CIBB, where our PhD students and postdocs have the opportunity to interact with renowned international and national researchers in a more informal setting. This is very important to inspire young researchers and to promote the establishment of new collaborations (2022/01/01)
Other (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/12/20 - 2023/12/20 Annual Meeting of the Center for Innovative Biomedicine and Biotechnology (CIBB) (2023/12/20 - 2023/12/20)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/12/11 - 2023/12/15 Winter School: "Neuroscience Meets Society: Transversal Skills for Future Neuroscientists of the Center for Neuroscience and Cell Biology (2023/12/11 - 2023/12/15)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/11/27 - 2023/11/27 I organized and hosted the seminar of Sandra Henriques Vaz at CIBB (2023/11/27 - 2023/11/27)
Seminar (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/06/02 - 2023/06/02 I organized and hosted the seminar of Bart de Strooper at CIBB (2023/06/02 - 2023/06/02)
Seminar (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/05/03 - 2023/05/03 Chair in the "Diseases Caused by Autoantibodies Against Neuronal Cell-Adhesion Proteins: Cellular and Molecular Mechanisms" Symposium of the 2023 FENS Regional Meeting (2023/05/03 - 2023/05/05)
Symposium (Co-organisor)
 Federation of European Neuroscience Societies, Belgium
2023/04/21 - 2023/04/21 I organized and hosted the seminar of Sara Calafate at CIBB (2023/04/21 - 2023/04/21)
Seminar (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/03/31 - 2023/03/31 I organized and hosted the seminar of Matthew Holt at CIBB (2023/03/31 - 2023/03/31)
Seminar (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/11/01 - 2023/11/30 Participation in the project 33 Voices of CNC-UC. The CNC-UC celebrated 33 years of history in November 2023. This project aimed to give voice to some of those who have made up or currently make up the CNC-UC and have been or are part of this history
Other
 33 Voices of CNC-UC
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/08/08 - 2023/08/11 Participation at the ESN-ISN 2023 Meeting
Conference
 ESN-ISN 2023 Meeting
International Society for Neurochemistry, Switzerland
2023/07/19 - 2023/07/19 Interview for Ciência Viva: I highlighted the impact of my summer internship experience at Ciência Viva, during high school, on my career as a researcher
Other
Ciência Viva, Portugal
2023/05/29 - 2023/06/09 Panelist in the round table on Scientific Careers in the "Advanced Imaging Methods in Neuroscience" course of the EIT Health Ageing PhD School from the University of Coimbra
Round table
 "Advanced Imaging Methods in Neuroscience" course
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/05/03 - 2023/05/05 Participation at the FENS Regional Meeting 2023 - Algarve
Conference
 FENS Regional Meeting 2023 - Algarve
Federation of European Neuroscience Societies, Belgium
2022/10/20 - 2022/10/21 Participation at the 8th European Synapse Meeting
Conference
 8th European Synapse Meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/30 - 2022/09/30 European Researchers night: in the context of the Green labs initiative at CIBB, we prepared an activity for the general public to illustrate the different type of plastics we can find in day-life products and how to proceed to recycle them. We also explain to the general public the measures we are taking in the lab to decrease the ecological footprint of our research activities
Festival
 European Researchers night 2022
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/09/29 - 2022/09/29 CNC-UC welcome day: I introduced our lab and projects to the newcomers of CNC-UC
Other
 CNC-UC welcome day
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/12/01 - 2021/12/03 Participation at the XVII Meeting of the Portuguese Society for Neuroscience
Conference
 XVII Meeting of the Portuguese Society for Neuroscience
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/11/24 - 2021/11/24 Meet the Scientists: activity organized by the Brain Gain initiative of CNC-UC with the purpose of introducing the topic of research to high-school and university students and inspire them to follow a career as a researcher
Round table
 Brain Gain - À Descoberta das Neurociências
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09/25 - 2018/09/29 Participation at the CSHL Conference on Molecular Mechanisms of Neuronal Connectivity
Conference
 Molecular Mechanisms of Neuronal Connectivity
Cold Spring Harbor Laboratory, United States
2018/07/02 - 2018/07/03 Participation at the Max-Planck-Post Event organized after the 68th Lindau Nobel Laureate Meeting
Seminar
 Max-Planck-Post Event organized after the 68th Lindau Nobel Laureate Meeting.
Max Planck Institute of Experimental Medicine, Germany
2018/06/24 - 2018/06/29 Participation at the 68th Lindau Nobel Laureate Meeting dedicated to Physiology and Medicine
Meeting
 68th Lindau Nobel Laureate Meeting dedicated to Physiology and Medicine
Council for the Lindau Nobel Laureate Meetings/Foundation Lindau Nobel Laureate Meetings, Germany
2017/05/07 - 2017/05/10 Participation at the EMBO Workshop on Cell Biology of the Neuron: Polarity, Plasticity and Regeneration
Conference
 Cell Biology of the Neuron: Polarity, Plasticity and Regeneration
European Molecular Biology Laboratory, Germany
2016/07/02 - 2016/07/06 Participation at the 10th FENS Forum of Neuroscience
Conference
 10th FENS Forum of Neuroscience
Federation of European Neuroscience Societies, Belgium
2016/06/01 - 2016/06/04 Participation at the 7th ISN 2016 Special Conference of Neurochemistry
Conference
 7th ISN 2016 Special Conference of Neurochemistry
International Society of Neurochemistry, Switzerland
2012/10/13 - 2012/10/17 Participation at the Society for Neuroscience Annual Meeting
Conference
 Society for Neuroscience Annual Meeting (New Orleans, USA).
Society for Neuroscience, United States
2012/10/11 - 2012/10/12 Participation at the 22nd Neuropharmacology Conference
Conference
 22nd Neuropharmacology Conference
Elsevier BV, Netherlands
2012/02/16 - 2012/02/17 Participation at the International Symposium on Ionotropic Glutamate Receptors
Conference
 International Symposium on Ionotropic Glutamate Receptors
Fundación Ciudad de las Artes y las Ciencias, Spain
2009/09/09 - 2009/09/13 Participation at the EMBO Conference on Protein Synthesis and Translational Control
Conference
 EMBO Conference Series on Protein Synthesis and Translational Control
European Molecular Biology Laboratory, Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/10/24 Thesis title: SORTING ID: Identification of axonal proteins trafficked through dendritic endosomes
Supervisor
 João Francisco Miranda Machado (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/10/17 Thesis title: Engineering CRISPR base editors to rescue Machado-Joseph disease in a patient derived neuronal model
(Thesis) Main arguer
 Miguel Tiago Cabral Dias (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/09/22 Thesis title: Dissecting the neuronal function of IgLON5, an uncharacterized cell adhesion molecule
Supervisor
 Beatriz Pereira Marques (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/09/18 Thesis title: Characterization of the RNA-binding protein hnRNPH2: a novel player in epileptogenesis
(Thesis) Main arguer
 Marta Sofia Santos Silva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/06/21 Thesis Title: Underlying Mechanisms of Autophagy to maintain Synaptic Function and Health
(Thesis) Main arguer
 Julien Vancanneyt (Master)
KU Leuven, Faculty of Medicine, Belgium

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/01/01 - Current Frontiers in Synaptic Neuroscience (1663-3563) Frontiers Media S.A.
2020/01/01 - Current Science Advances (2375-2548) American Association for the Advancement of Science
2020/01/01 - Current Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media S.A.
2020/01/01 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2020/01/01 - Current Cells (2073-4409) MDPI
2020/01/01 - Current Biomolecules (2218-273X) MDPI
2020/01/01 - Current Biology (2079-7737) MDPI
2020/01/01 - Current Neurochemical Research (1573-6903) Springer

Association member

Society Organization name Role
2022/01/01 - Current International Society for Neurochemistry Member
2022/01/01 - Current European Society for Neurochemistry Member
2022/01/01 - Current Federation of European Neuroscience Societies Member
2021/01/01 - Current Portuguese Society for Neuroscience Member
2012/09/01 - 2013/08/31 Society for Neuroscience Member

Committee member

Activity description
Role 		Institution / Organization
2023/01/01 - Current Representative of the PhD Researchers at the Center for Innovative Biomedicine and Biotechnology (CIBB). We are responsible for developing activities to enhance the scientific careers of PhD researchers working at CIBB, as well as for the general CIBB community, and to provide legal and general support to PhD researchers at CIBB
Member
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/01/01 - Current Green-Keeper: in the context of the Green labs initiative at Centre for Innovative Biomedicine and Technology (CIBB), I am responsible for the implementation of measures in the lab and at the CNC-UC that aim at decreasing the ecological footprint of our research activities. Particularly, together with other colleagues, we made a video that highlights some of these measures
Member
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/10/23 - 2033/11/10 Instructor for Experimental Work at the Advanced Techniques for Synapse Biology Course (Cajal Advanced Neuroscience Training) Bordeaux School of Neuroscience, France
2024/01/29 - 2024/02/02 Lecturer at the Synapse Assembly, Function and Plasticity course of the PhD Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/01/29 - 2024/02/02 Instructor for Experimental Work at the Synapse Assembly, Function and Plasticity course of the PhD Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/12/05 - 2023/12/05 Lecturer at the Cellular and Molecular Neurobiology course of the Master in Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/01/16 - 2023/01/20 Instructor for Experimental Work at the Synapse Assembly, Function and Plasticity course of the PhD Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/07 - 2022/02/11 Lecturer at the Synapse Biology course of the PhD Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/10/23 - 2012/10/23 Lecturer at the Molecular Neuroscience course of the PhD Program in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/01/31 - Current Jury member of Inês Torquato Afonso's PhD Thesis committee: "Expression of activity-regulated inhibitor of death (AID) genes as a therapeutic strategy for Machado-Joseph disease", Doctoral Program in Biomedical Sciences, University of Algarve, Portugal
Evaluator
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal Fundação para a Ciência e a Tecnologia
2023/06/22 - Current Jury member of Ana Rita Figueira's PhD Thesis committee: "P2Y1R-CRMP2-NMDAR, a neurodegenerative mechanism shared by different brain diseases", PhD Program in Experimental Biology Biomedicine of the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
Evaluator
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Fundação para a Ciência e a Tecnologia

Interview (tv / radio show)

Program Topic
2022/03/24 - 2022/03/24 Observatório RUC: interview at the Radio of the University of Coimbra (RUC) during the Brain Awareness Week. We discussed our research at CNC-UC, and some of the challenges of a career in an academic research environment Observatório RUC

Journal scientific committee

Journal title (ISSN) Publisher
2021/04/23 - Current Frontiers in Synaptic Neuroscience (Review Editor) (1663-3563) Frontiers Media SA
2020/03/20 - Current Frontiers in Cellular Neuroscience (Review Editor) (1662-5102) Frontiers Media SA

Mentoring / Tutoring

Topic Student name
2022/10/01 - 2025/09/30 Mentorship during PhD Ana Sofia Figueira

Other jury / evaluation

Activity description Institution / Organization
2023/06/25 - 2023/06/30 Reviewer for Next Gen Science sessions during the 72nd Lindau Nobel Laureate Meeting, Lindau, Germany. Council for the Lindau Nobel Laureate Meetings/Foundation Lindau Nobel Laureate Meetings, Germany
Distinctions

Award

2023 Emerging Group Leaders Symposia for the ISN-ESN 2023 Meeting, Porto, Portugal.
International Society for Neurochemistry, Switzerland
2022 SPN Best Manuscript 2021: Honorable mention (2nd place: Ribeiro et al., 2021).
Sociedade Portuguesa de Neurociências, Portugal
2008 Top 3% of Students (Bachelor of Science in Biology)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Other distinction

2021 Marie Sklodowska-Curie Action Individual Fellowship, Call: H2020-MSCA-IF-2020
European Commission, Belgium
2021 Scientific Employment Stimulus (Assistant Researcher) - 4th edition
Fundação para a Ciência e a Tecnologia, Portugal
2020 Selected for the first edition of the Visiting Postdoctoral EU-LIFE seminars programme
EU-LIFE Alliance, Spain
2018 Postdoctoral Fellowship Renewal - 12N0319N
Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2018 Travel Grant - K1E3518N
Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2018 68th Lindau Nobel Laureate Meeting dedicated to Physiology and Medicine
Council for the Lindau Nobel Laureate Meetings/Foundation Lindau Nobel Laureate Meetings, Germany
2018 Max-Planck-Post Event organized after the 68th Lindau Nobel Laureate Meeting
Max Planck Institute of Experimental Medicine, Germany
2015 Marie Sklodowska-Curie Action Individual Fellowship, Call: H2020-MSCA-IF-2014
European Commission, Belgium
2015 Postdoctoral Fellowship - 12N0316N
Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2009 PhD Student Fellowship - SFRH/BD/47879/2008
Fundação para a Ciência e a Tecnologia, Portugal