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Mariana Fontoura Vassal obtained her BSc in Bioengineering from the University of Beira Interior in 2019. Her final graduation project on "Dense bioceramic coatings for metallic implants" was conducted at the Center for Mechanical and Aerospace Science of the University of Beira Interior, under the supervision of Prof. Abílio Silva and Dr. João Nunes Pereira. At the end of 2021, she obtained her MSc in Molecular and Cell Biology at the University of Aveiro. Her master's thesis "Different strategies to attenuate the male reproductive toxicity of ZnO nanoparticles" was developed at the Institute of Biomedicine (iBiMED), under the guidance of Prof. Maria de Lourdes Pereira, and Prof. Sandra Rebelo. There, she gained expertise in various laboratory techniques, namely, mammalian cell culture, cell viability assays, microscopy, immunoblotting, immunocytochemistry, oxidative stress assays, and so on. During 2022, she worked as an R&D Engineer at Spinner Dynamics, where researched safer, more effective, and sustainable disinfection solutions. Among her duties, she was in charge of defining the requirements and specifications for new products, preparing R&D project proposals, preparing technical-scientific reports, and interacting with universities, research institutions, and different companies. As of 2023, she is a researcher with a fellowship in the scope of the project 'BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer's Disease at the Department of Medical Sciences, University of Aveiro. Mariana authors 5 full papers in international peer review journals.
Identification

Personal identification

Full name
Mariana Vassal

Citation names

  • Vassal, Mariana

Author identifiers

Ciência ID
D411-E99C-E2C1

Email addresses

  • marianavassal@ua.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Health Sciences
  • Engineering and Technology - Materials Engineering - Ceramics
  • Engineering and Technology - Materials Engineering - Composites

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2023/05/08 - 2023/05/19
Ongoing
Laboratory Animal Science Course - FELASA accredited course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/01/09 - 2023/04/17
Ongoing
Curso Avançado em Investigação Científica (Outros)
Major in Ciências e Engenharia
Universidade de Aveiro, Portugal
2019/09 - 2021/12
Concluded
Biologia Molecular e Celular (Mestrado)
Universidade de Aveiro, Portugal
"Different strategies to attenuate the reproductive toxicity of ZnO NPs" (THESIS/DISSERTATION)
19
2015 - 2019
Concluded
Bioengenharia (Licenciatura)
Universidade da Beira Interior, Portugal
"Dense bioceramic coatings for metallic implants" (THESIS/DISSERTATION)
16
Affiliation

Positions / Appointments

Category
Host institution
Employer
2022/03/21 - 2022/12/24 Engenheira de I&D Spinner Dynamics, Portugal

Others

Category
Host institution
Employer
2023/10/01 - Current Bolseira de Doutoramento Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro, Portugal
2023/03/01 - 2023/09/30 Bolseira de Investigação Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal
Projects

Contract

Designation Funders
2023/03/01 - Current BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s Disease - BRI2@ADTHERAPY
PTDC/BTM-TEC/3792/2021
Research Fellow
Universidade de Aveiro, Portugal

Karolinska Institutet, Sweden

Instituto de Neurobiología Ramón y Cajal, Spain
Fundação para a Ciência e a Tecnologia
2022/03/24 - 2022/12/24 GermIrrad – Automated Germicidal Irradiation System
POCI-01-0247- FEDER-072237
Researcher
Spinner Dynamics, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto, Portugal
Agência Nacional de Inovação SA

Fundação para a Ciência e a Tecnologia

Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Ongoing
Outputs

Publications

Conference poster
  1. Rebelo, Sandra; Vassal, Mariana; Savchuk, Ruslana; Chen, Gefei; Nilsson, Per; Tambaro, Simone; Martins, Filipa. "A novel pro-neurogenic therapeutic approach for Alzheimer´s disease based on BRI2 proteolytic processing". Paper presented in FENS Forum, 2024.
  2. Martins, Filipa; Vassal, Mariana; Savchuk, Ruslana; Serrano, Julia; Martínez-Murillo, Ricardo; Tambaro, Simone; Rebelo, Sandra. "Exploring the contribution of BRI2 expression and proteolytic processing on neuronal differentiation". Paper presented in FENS Forum, 2024.
  3. Vassal, Mariana; Martins, Filipa; Savchuk, Ruslana; Camões, Fátima; Martínez-Murillo, Ricardo; Tambaro, Simone; Rebelo, Sandra. "Understanding the contribution of BRI2 processing for neuronal Differentiation". Paper presented in VII iBiMED Symposium on Biomedicine, 2024.
  4. Vassal, Mariana; Martins, Filipa; Savchuk, Ruslana; Camões, Fátima; Serrano, Julia; Martínez-Murillo, Ricardo; Rebelo, Sandra. "Unravelling BRI2 expression and processing during neuronal differentiation". Paper presented in 11th IBRO World Congress of Neuroscience, 2023.
  5. Vassal, Mariana; Martins, Filipa; Savchuk, Ruslana; Chen, Gefei; Zhao, Hongjing; Nilsson, Per; Tambaro, Simone; Rebelo, Sandra. "BRI2 Protein: A Promising Therapeutic Target for Innovative Alzheimer's Disease Treatment". Paper presented in Encotnro Ciência 2023, 2023.
  6. Vassal, Mariana; Martins, Filipa; Savchuk, Ruslana; Chen, Chefei; Zhao, Hongjing; Nilsson, Per; Tambaro, Simone; Rebelo, Sandra. "Exploring the Potential of BRI2 Protein as a Novel Therapeutic Avenue for Alzheimer's Disease". Paper presented in Novel Diagnostic Tools for Alzheimer's Disease, 2023.
  7. Vassal, Mariana; Martins, Filipa; Savchuk, Ruslana; Chen, Chefei; Zhao, Hongjing; Nilsson, Per; Tambaro, Simone; Rebelo, Sandra. "Novel perspectives on neuronal differentiation: insights from BRI2 protein". Paper presented in VI IBIMED Symposium: from fundamental research to clinical practice, 2023.
  8. Sousa, Mariana; Sousa, Cátia A.; Vassal, Mariana; Braga, Daniel; Simões, Manuel. "Far-UV-C radiation demonstrated germicidal activity against Escherichia coli and Staphylococcus sp.". Paper presented in II TOXRUN International Congress 2023, 2023.
  9. Vassal, Mariana; Pereira, Cátia D.; Martins, Filipa; Vera L. M. Silva; Silva, Artur; Senos, Ana M. R.; Costa, Maria Elizabete; Maria de Lourdes Pereira; Rebelo, Sandra. "Chalcone supplementation as a strategy to mitigate the reproductive toxicity of ZnO nanoparticles". Paper presented in CICECO Jornadas 2022 - Hand in Hand in Science, 2022.
  10. Vassal, Mariana; Rebelo, Sandra; Maria de Lourdes Pereira. "Adverse effects of metal oxide nanoparticles on male germ cells". Paper presented in WebRePRO I Reproductive Science & Fertility Virtual Summit, 2021.
Journal article
  1. Vassal, Mariana; Martins, Filipa; Monteiro, Bruno; Tambaro, Simone; Martinez-Murillo, Ricardo; Rebelo, Sandra. "Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research". Molecular Neurobiology 62 1 (2024): 46-76. https://doi.org/10.1007/s12035-024-04246-w.
    10.1007/s12035-024-04246-w
  2. Vassal, Mariana; Gomes, Inês B.; Pereira, Ana Rita; Simões, Manuel; Braga, Daniel F.O.; Teixeira, Bruno. "Combination of UVC light with antimicrobial agents for enhanced disinfection of surfaces and liquids". Journal of Environmental Chemical Engineering 11 3 (2023): 109639. http://dx.doi.org/10.1016/j.jece.2023.109639.
    10.1016/j.jece.2023.109639
  3. Pereira, Ana Rita; Braga, Daniel F.O.; Vassal, Mariana; Gomes, Inês B.; Simões, Manuel. "Ultraviolet C irradiation: A promising approach for the disinfection of public spaces?". Science of The Total Environment (2023): 163007. http://dx.doi.org/10.1016/j.scitotenv.2023.163007.
    10.1016/j.scitotenv.2023.163007
  4. Vassal, Mariana; Pereira, Cátia D.; Martins, Filipa; Silva, Vera L. M.; Silva, Artur M. S.; Senos, Ana M. R.; Costa, Maria Elisabete V.; Pereira, Maria de Lourdes; Rebelo, Sandra. "Different Strategies to Attenuate the Toxic Effects of Zinc Oxide Nanoparticles on Spermatogonia Cells". Nanomaterials 12 20 (2022): 3561. http://dx.doi.org/10.3390/nano12203561.
    Published • 10.3390/nano12203561
  5. Vassal, Mariana; Rebelo, Sandra; Pereira, Maria de Lourdes. Corresponding author: Rebelo, Sandra. "Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System". International Journal of Molecular Sciences 22 15 (2021): 8061. http://dx.doi.org/10.3390/ijms22158061.
    Published • 10.3390/ijms22158061
  6. Vassal, Mariana J.; Nunes-Pereira, J.; Miguel, Sónia; Correia, Ilidio; Silva, Abilio. "Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites". (2019): http://hdl.handle.net/10400.6/6897.
    Published • 10.1016/j.ceramint.2019.01.122
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/18 Understanding the contribution of BRI2 processing and phosphorylation for neuronal differentiation: towards a pro-neurogenic therapy for Alzheimer’s disease Research Summit 2024
Universidade de Aveiro (Aveiro, Portugal)
2023/05/25 Novel perspectives on neuronal differentiation: insights from BRI2 protein VI IBIMED Symposium: from fundamental research to clinical practice
Institute of Biomedicine - iBiMED (Aveiro, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023 - Current Dissemination activity of University of Aveiro, 'Academia de Verão'. 'Da molécula à doença' was part of the program of Medical Sciences Department. (2023/07/08 - 2023/07/20)
Other (Other)
Universidade de Aveiro, Portugal
2021/03/24 - Current "Webinar Series on Biomedicine: Meet the Professor" aims to promote the development of education, research and investigation, by providing a space for communication and dissemination of science (2021/03/24)
Seminar (Member of the Organising Committee)
Universidade de Aveiro, Portugal
2023/09/01 - 2025/06/30 "VIII iBiMED symposium: biomedicine beyond boundaries" aims to offer a platform for the exchange of scientific discoveries, fostering collaborations among iBiMED members and external experts in the field of biomedicine (2025/05/22 - 2025/05/23)
Symposium (Member of the Organising Committee)
Universidade de Aveiro, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2018/04/23 - Current The Portuguese conference on fracture aims to be a forum for the discussion of relevant scientific and technical developments in fatigue and fracture of materials, with thematic sessions for the different research fields and a set of plenary lectures from internationally known researchers.
Conference
XVI Portuguese Conference on Fracture
2016/04/22 - Current It is the largest student-organised Bioengineering event in Portugal, which its main purpose is to present to the academic community the most recent and innovative projects in the area of Bioengineering with applications on issues of the modern society.
Symposium
7 th Symposium on Bioengineering
Distinctions

Award

2022 Merit Scholarship
Direção-Geral de Ensino Superior (DGES), Portugal