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ACosta has a Biochemistry degree and a PhD in Biomedicine by the Porto University. She has been devoted to study signal transduction mechanisms in Microbiology and Oncobiology. ACosta career began at Complutense University of Madrid, where she developed her BSc thesis on Candida albicans stress signaling pathways. Then she moved to the Oncobiology field at Institute of Pathology and Molecular Immunology of Porto University (IPATIMUP), where she studied the molecular mechanisms associated with cancer progression on thyroid and gastric cancer. There, Acosta developed her PhD (FCT grant awarded), where in collaboration with the Max-Planck Institute for Infection Biology, she studied the Helicobacter pylori role on the regulation of cell adhesion and invasion in gastric cancer. From this, she published 3 articles as 1st author, and had a PhD dissertation unanimously approved with distinction. As a post-Doc ACosta worked on the molecular mechanisms involved in glioma cell invasion, at the Institute of Life and Health Sciences (ICVS-Braga), which resulted in a 1st author original article. In 2015, she joined the Institute for Research & Innovation in Health (i3S) with an FCT-awarded post-doctoral grant to investigate colon cancer microenvironment. Over the last 5 years, ACosta became the Principal Investigator of the Hypoxia and Modulation of Tumor Microenvironment research line at the Tumor and Microenvironment Interactions Group at i3S. In this scope, ACosta supervised 4 MSc students, and was the senior author of an original article, published in a Q1 journal, contributed with 3 oral presentations, and 11 posters in national and international conferences, 2 awarded as Best Poster. In 2020, ACosta was awarded with 1st nCounter Tumor Signaling 360 Panel Grant as Principal Investigator, to study the hypoxia-driven immunomodulation in colon cancer. In 2020 and 2022 she interrupted her scientific activity due to a maternity leave. ACosta was team member of 11 FCT-funded projects and 2 International consortia. ACosta supervised 5 MSc students, and mentored 13 students (6 PhD, 5 MSc, 2 BSc). Her work was recognized by the invitation to be the main arguer in 5 MSc jury committees, member of 2 PhD students monitoring committees, and part of scientific and evaluation committee of several scientific meetings. ACosta was involved in the organization of post-graduate courses, and is a science ambassador to general public/schools science dissemination. She is an EACR and ASPIC member, and reviewer in International Scientific Journals. In November 2024, ACosta had published 23 peer-reviewed articles: 6 as 1st author, and 2 as senior author having a 14 h-index and 1186 citations (Scopus). She is also author of 20 conference proceedings and >50 oral/poster scientific communications in national and international meetings, 18 as senior author, and 3 book chapters.
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Identification

Personal identification

Full name
Ângela Margarida Amorim Costa

Citation names

  • Costa, Ângela
  • Angela M Costa
  • Angela Margarida Costa
  • Angela Amorim-Costa

Author identifiers

Ciência ID
D317-859E-F79C
ORCID iD
0000-0002-8911-1043
Scopus Author Id
57202713437

Email addresses

  • angela.amorimcosta@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6070 (Professional)

Addresses

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Upper intermediate (B2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2016 - 2016
Concluded
 FELASA accreditation – Category C (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Categoria C
2008/01/01 - 2012/10/31
Concluded
 Biomedicina (Doutoramento)
Major in Sem especialidade
Universidade do Porto Faculdade de Medicina, Portugal
"Exploring the Relationship Between Helicobacter Pylori and Host Cell Motility and Adhesion: from Phenotypes to Molecular Mechanisms" (THESIS/DISSERTATION)
2009/08 - 2009/08
Concluded
 EMBO|FEBS Lecture Course - Summer School on Molecular mechanisms in signal transduction and cancer (Outros)
EMBO/FEBS, Germany
2000 - 2004
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Hog1 as a regulator of MAP kinases pathway in Candida albicans – study of a mutant of Hog1" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - 2024/12/31 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/10/01 - 2018/12/31 Postdoc (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2015/03/01 - 2015/06/30 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/09/01 - 2014/12/31 Postdoc (Research) Universidade do Porto Faculdade de Engenharia, Portugal
2012/11/01 - 2014/03/31 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/08/01 - 2012/10/31 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2008/04/01 - 2008/06/30 Researcher (Research) Max-Planck-Institut für Infektionsbiologie, Germany
2004/03/01 - 2004/07 Research Trainee (Research) Universidad Complutense de Madrid Facultad de Farmacia, Spain
Projects

Grant

Designation Funders
2014 - 2014 Sustainable Cleaning and Disinfection in Fresh-Cut Food Industries
info:eu-repo/grantAgreement/EC/FP7/287514/EU
Post-doc Fellow
Universidade do Porto Faculdade de Engenharia, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development
2012 - 2014 Potential predictive biomarkers in anti-RTK therapy response in gliomas: studies in vitro and in vivo
PTDC/SAU-TOX/114549/2009
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2007 - 2008 A global RNAi approach to unravel eukaryotic host functions that modulate bacterial infections (acronym RNAi-Net)
info:eu-repo/grantAgreement/FCT/3599-PPCDT/81992/PT
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 European Union
2006 - 2006 Effects of Helicobacter pylori on gastric epithelial cells
info:eu-repo/grantAgreement/FCT/POCI/56681/PT
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2004 - 2005 Identification and characterization of the mechanisms involved in the acquisition of motility and invasibility of papilary thyroid carcinoma cells
POCTI/CBO/38567/2001
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2017/01/01 - 2021/03/31 Estaminalidade das células do cancro: um desafio e uma oportunidade para avançar no tratamento em Oncologia
SAICTPAC/0022/2015
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/10/01 - 2018/12/31 Influence of tumor-associated macrophages on colorectal cancer invasion: from invadopodia to therapeutics
SFRH/BPD/109446/2015
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/12/31 EXPLORING THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND HOST CELL MOTILITY, ADHESION, AND INVASION: FROM PHENOTYPES TO MOLECULAR MECHANISMS
SFRH/BD/36013/2007
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2022/01/01 - 2024/12/31 Dissect the tumor microenvironment to battle cancer radioresistance and immune escape
PTDC/MED-ONC/4165/2021
Post-doc
Fundação para a Ciência e a Tecnologia
2021/06/01 - 2023/09/30 PRIMING - Impact of maternal obesity on early-life microbiota-induced immune system priming.
Biocodex Portugal Grant 2021
Researcher
Biocodex Microbiota Foundation
2022/01/01 - 2023/06/30 STRESS AND BREAST CANCER METASTASIS TO BONE: Exploring the Yin-Yang of sympathetic adrenergic signaling
EXPL/BIA-BQM/0255/2021
Post-doc
Fundação para a Ciência e a Tecnologia
2018 - 2021 MAGICIAM - a MAcrophaGe Immunomodulatory-delivery system to prevent Cancer Invasion And Metastasis
POCI-01-0145-FEDER-031849
Post-doc
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
2018 - 2021 Modeling Angiogenesis in Type 2 Diabetes Mellitus - integrating experimental and theoretical approaches
Angiodia
Post-doc
Fundação para a Ciência e a Tecnologia
2016 - 2017 Tackling cancer stem cells: a challenge and an opportunity to advance in anti-cancer therapy
Cancel_Stem
Post-doc
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2011 - 2012 IDENTIFICATION OF HELICOBACTER PYLORI VIRULENCE GENES
PTDC/BIA-MIC/116890/2010
Other
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Catarina Moreira-Barbosa ; Andreia Matos ; Rui Fernandes ; Miguel Mendes; Rafaela Rodrigues ; Cruz, Tânia; Angela M Costa; et al. "The role of fatty acids metabolism on cancer progression and therapeutics development". In Biactive Lipids. Elsevier, 2022.
    In press
  2. Wilton, Joana; Michael Tellier; Takayuki Nojima ; Angela M Costa; Maria Jose Oliveira; Alexandra Moreira. "Simultaneous studies of gene expression and alternative polyadenylation in primary human immune cells". In Methods in Enzymology, 349-399. 2021.
    Published
  3. Costa, A.M.; Oliveira, M.J.. "Cancer cell invadopodia: Visualization and quantification tools". 299-315. 2017.
Conference abstract
  1. Wilton J; Freitas Jaime; Pereira-Castro I; Angela Margarida Costa; Castro, Flávia; Oliveira MJ; Moreira, Alexandra. "Don't shoot the messenger: RNA at the center of unraveling mechanisms of gene regulation in the cancer-macrophage microenvironment". Paper presented in 8th International conference on Tumor Microenvironment, Lisboa, 2018.
  2. Angela Margarida Costa; Martins, Flávia; Oliveira, Rosa; Pinto, F.; Castro, Flávia; Cardoso AP; Cavadas B; et al. "The hypoxia impact in the macrophage-driven cancer cell invasive phenotype". Paper presented in 8th International conference on Tumor Microenvironment, Lisboa, 2018.
    10.1007/s12307-018-0212-6
  3. Martins, Flávia; Pinto ML; Silva AJ; Oliveira MJ; Angela Margarida Costa. "The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay". Paper presented in Yes Meeting, Porto, 2017.
    http://dx.doi.org/10.1016/j.pbj.2017.07.098
  4. Freire AF; Ferreira RM; Pinto-Ribeiro, I.; Angela Margarida Costa; Moreira AR; Figueiredo, C. "Helicobacter pylori increases matrix metalloproteinase-10 expression via ETS- 1.". Paper presented in 29th International Workshop on Helicobacter and Microbiota in Inflammation and Cancer, Magdeburg, 2016.
    10.1111/hel.12344
  5. Feás-Rodríguez, Noa; Costa, Angela M.; Alvarez Gago, Tomás; Mateos Otero, Juan José; Cameselle Teijeiro, Jose Manuel; Muñoz, Raquel; Garcia-Rostan, Ginesa Maria. "Abstract 4222: Usefulness of VE1 immunohistochemical detection of BRAFV600E in aggressive thyroid cancers (PDCs and UCs)". Paper presented in 107th Annual Meeting of the American Association for Cancer Research, New Orleans, 2016.
    10.1158/1538-7445.am2016-4222
  6. Angela Margarida Costa; Ferreira RM; Carneiro, F.; Leite, M.; Figueiredo, C. "Helicobacter pylori CagA-positive strains activate matrix metalloproteinase-10 in gastric cells via ERK and JNK pathways". Paper presented in São Paulo School of Advanced Science – Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment, São Paulo, 2013.
  7. Angela Margarida Costa; Ferreira RM; Carneiro, F.; Leite, M.; Figueiredo, C. "Helicobacter pylori CagApositive strains activate matrix metalloproteinase-10 in gastric cells via ERK and JNK pathways.". Paper presented in XXIVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, Ljubljana, 2012.
    10.1111/j.1523-5378.2012.00986.x
  8. Angela Margarida Costa; Ballester GF; Fresno, M.F.; Cameselle-Teijeiro, J.; García-Rostán, G.. "Functional relevance of particular residues within the BRAF kinase domain in anaplastic thyroid carcinoma". Paper presented in 103rd Annual Meeting of the American Association for Cancer Research, Chicago, 2012.
    doi: 10.1158/1538-7445.AM2012-4171
  9. Angela Margarida Costa; Oliveira MJ; Churin Y; Ferreira RM; Leite, M.; Meyer TF; Figueiredo, C. "Nck, PLC-g, and c-Src are involved in Helicobacter pylori-mediated host cell invasion in a c- Met-dependent manner.". Paper presented in XXIVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, Dublin, 2011.
    10.1111/j.1523-5378.2011.00886.x
  10. Angela Margarida Costa; Oliveira MJ; Churin Y; Ferreira RM; Leite, M.; Meyer TF; Figueiredo, C. "Molecular mechanisms underlying Helicobacter pylori-mediated host cell invasive phenotype.". Paper presented in 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Torino, 2011.
    10.1111/j.1742-4658.2011.08137.x
  11. Costa AC; Leite, M.; Pinto ML; Ferreira RM; Angela Margarida Costa; Machado JC; Atherton, J.C.. "Helicobacter pylori disturbs gastric epithelial tight junctions in an inflammation-independent manner.". Paper presented in XXIII International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Infl ammation and Gastric Cancer, Rotterdam, 2010.
    10.1111/j.1523-5378.2010.00771.x
  12. Angela Margarida Costa; Fresno, M.F.; Herrero, A.; Cameselle-Teijeiro, J.; García-Rostán, G.. "Abstract 3137: Oncogenic activation of PI3K and MAPK pathways in 95 aggressive thyroid carcinomas (PDC and ATC). Co-activation prevalence.". Paper presented in 101st Annual Meeting of the American Association for Cancer Research, 2010.
    doi: 10.1158/1538-7445.AM10-3137
  13. Costa AC; Pinto ML; Angela Margarida Costa; Leite, M.; Ferreira RM; Oliveira MJ; Atherton JC; Mareel, M.; Figueiredo, C. "AGS cells expressing E-cadherin establish tight junctions and constitute a useful model for studying Helicobacter pylori infection.". Paper presented in 22nd International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Porto, 2009.
    10.1111/j.1523-5378.2009.706_8.x
  14. Oliveira MJ; Angela Margarida Costa; Costa AC; Machado JC; Seruca R; Mareel, M.; Figueiredo, C. "Ecadherin and CagA associate in a tetrameric complex that suppresses Helicobacter pylori-mediated cell invasion.". Paper presented in 21st International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, Riga, 2008.
    10.1111/j.1523-5378.2008.638_1.x
  15. Oliveira, Maria J.; Costa, Angela M.; Costa, Ana C.; Machado, Jose C.; Seruca, Raquel; Mareel, Marc; Figueiredo, Ceu. "26 E-Cadherin and CagA Associate in a Tetrameric Complex That Suppresses Helicobacter pylori-Mediated Cell Invasion". Paper presented in Digestive Disease Week (DDW) – American Gastroenterological Association, San Diego, 2008.
    10.1016/s0016-5085(08)60022-0
  16. Costa AC; Ferreira RM; De Bruyne G; Angela Margarida Costa; Oliveira MJ; Atherton, J.; Mareel, Marc; Figueiredo, C. "Helicobacter pylori delocalizes tight junction molecules.". Paper presented in 20th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, Istambul, 2007.
    10.1111/j.1523-5378.2007.00540_10.x
  17. Oliveira MJ; Angela Margarida Costa; Costa AC; Suriano, G.; Ferreira RM; Machado JC; Seruca R; Mareel, Marc; Figueiredo, C. "The E-cadherin/catenin complex suppresses Helicobacter pylori-mediated cancer cell invasion.". Paper presented in 20th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, Istambul, 2007.
    10.1111/j.1523-5378.2007.00540_1.x
  18. Oliveira MJ; Angela Margarida Costa; Costa AC; Ferreira RM; Suriano, G.; Machado JC; Seruca R; Mareel, M.; Figueiredo, C. "The E-cadherin/catenin complex suppresses Helicobacter pylori-mediated cancer cell Invasion". Paper presented in Digestive Disease Week (DDW) - American Gastroenterological Association, Washington, 2007.
    10.1016/s0016-5085(07)60009-2
  19. Oliveira MJ; Costa AC; Angela Margarida Costa; Atherton, J.; Machado JC; Seruca R; Mareel, M.; Leroy, A.; Figueiredo, C. "Helicobacter pylori Induces Gastric Epithelial Cell Invasion in a c- Met and cagPAI-Dependent Manner.". Paper presented in 19th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, Wroclaw, 2006.
    10.1111/j.1523-5378.2006.00419_5.x
Conference poster
  1. Magalhães, Maria Inês; Maria João Azevdo; Castro, Flávia; Maria Jose Oliveira; Angela M Costa; Sampaio-Maia, Benedita. "Impact of Maternal Obesity on Microbiota-Dependent Immune Programming in Early-life". Paper presented in 2nd Conference of the Doctoral Program in Metabolism-Clinical and Experimental, 2024.
  2. Maria Peixoto; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Ângela Marques-Magalhães; Ana Luisa Machado; Fernandes, Veronica; Luisa Pereira; Maria Jose Oliveira; Angela Amorim-Costa. "KRT17 e TPSAB1/B2 estão envolvidas na modulação do microambiente de cancro do cólon mediada pela hipóxia". Paper presented in 6º ENJIO - ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA, 2024.
  3. Maria Peixoto; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Fernandes, Veronica; Luisa Pereira; Maria Jose Oliveira; Angela Amorim-Costa. "KRT17 and TPSAB1/B2 are involved in hypoxia-driven immunomodulation at the colon cancer microenvironment". Paper presented in VII iBiMED Symposium - Universidade de Aveiro, 2024.
  4. Maria Peixoto; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Fernandes, Veronica; Luisa Pereira; Maria Jose Oliveira; Angela Amorim-Costa. "Hypoxia significantly alters the gene expression program at the colon cancer microenvironment: KRT17 and TPSAB1/B2 as critical players.". Paper presented in 30th Porto Cancer Meeting, 2024.
  5. Maria Peixoto; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Fernandes, Veronica; Luisa Pereira; Maria Jose Oliveira; Angela Amorim-Costa. "The role of hypoxia in the KRT17 and TPSAB1/B2-mediated modulation of the colon cancer microenvironment". Paper presented in IJUP-Encontro de Investigação Jovem da Universidade do Porto, 2024.
  6. Ana Catarina Ribeiro; Ângela Marques-Magalhães; Pinto, Marta Laranjeiro; Marta Teixeira Pinto; Angela Amorim-Costa; Bruno Pereira; Raquel Almeida; Cardoso, Ana Patrícia; Maria Jose Oliveira. "Unveiling the mechanisms of CCL18-mediated colorectal cancer cell invasion". Paper presented in IJUP-Encontro de Investigação Jovem da Universidade do Porto, 2024.
  7. Maria Peixoto; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Fernandes, Veronica; Luisa Pereira; Maria Jose Oliveira; Angela Amorim-Costa. "KRT17 and TPSAB1/B2 are involved in hypoxia-driven immunomodulation at the colon cancer microenvironment". Paper presented in 5th Symposium on Immunomodulation in Cancer & Regeneration, 2024.
  8. Ana Catarina Ribeiro; Ângela Marques-Magalhães; Pinto, Marta Laranjeiro; Marta Teixeira Pinto; Angela Amorim-Costa; Bruno Pereira; Raquel Almeida; Cardoso, Ana Patrícia; Maria Jose Oliveira. "Uncover the mechanisms driving the invasion of colorectal cancer cells via CCL18". Paper presented in 5th Symposium on Immunomodulation in Cancer & Regeneration, 2024.
  9. Rita Fialho Santos; Machado, Ana Luísa; Luisa Pereira; Angela M Costa. "HIF1A-associated immunomodulation at the colon cancer microenvironment". Paper presented in III ASPIC-ASEICA International Meeting, 2023.
  10. Cardoso, Ana Patrícia; Angela M Costa; Luisa Pereira; Maria Jose Oliveira. "Colon cancer patients with MSI tumors enriched in CCL18/macrophages have worse overall survival". Paper presented in III ASPIC-ASEICA International Meeting, 2023.
  11. Cruz, Tânia; Verónica Fernandes; Luísa Pereira; Angela M Costa. "SLC11A2 (DMT1) expression is downregulated by macrophagic infiltration at right colon tumors". Paper presented in 1st Symposium on Iron Metabolism and Cancer, 2023.
  12. Magalhães, Inês; Maria João Azevedo; Maria Jose Oliveira; Angela M Costa; Sampaio-Maia, Benedita. "PRIMING: Impact of maternal obesity on early-life microbiota-induced immune system priming.". Paper presented in Yes Meeting, 2023.
  13. Rita Fialho Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Luisa Pereira; Maria Jose Oliveira; Angela M Costa. ". Hypoxia-driven immunomodulation at the colon cancer microenvironment.". Paper presented in XXIX Porto Cancer Meeting, 2023.
  14. Cardoso, Ana Patrícia; Angela M Costa; Luisa Pereira; Maria Jose Oliveira. "CCL18/macrophages predict poor prognosis in patients with MSI colon cancer". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  15. Ana Rita Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Luísa Pereira; Maria Jose Oliveira; Angela M Costa. "Hypoxia-driven immunomodulation at the colon cancer microenvironment". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  16. Magalhães, Maria Inês; Azevedo, M. J. ; Castro, Flávia; Maria José Oliveira; Angela M Costa; Sampaio-Maia, Benedita. ""Impact of maternal obesity on early-life microbiota-induced immune system priming - a preliminary study"". Paper presented in Dia Nacional do Laboratório de Microbiologia - Microrganismos na Saúde e na Doença (Faculdade de Farmácia da Universidade do Porto), 2022.
  17. Ferreira, Sara; Angela M Costa; Canão, Pedro Amoroso; Castro, Flávia; Carneiro, Fatima; Maria Jose Oliveira; Cardoso, Ana Patrícia. "The Role of the Extracellular Matrix on Cancer Stemness and Immunogenicity". Paper presented in 4th SICR-Symposium on Immunomodulation in Cancer & Regeneration, 2022.
  18. Maria Inês Magalhães; Maria João Azevedo; Angela M Costa; Maria Jose Oliveira; Sampaio-Maia, Benedita. "Development of a cellular model to understand early-life gut microbiota-induced immune system priming.". Paper presented in Annual International (bio)Medical Students (AIMS) Meeting, 2022.
  19. Anas Rita Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Maria Inês Magalhães; Maria Jose Oliveira; Angela M Costa. "Unravel the role of hypoxia on immunomodulation at the colon cancer microenvironment.". Paper presented in IJUP-Encontro de Investigação Jovem da Universidade do Porto, 2022.
  20. Maria Inês Magalhães; Maria João Azevedo; Maria Jose Oliveira; Angela M Costa; Sampaio-Maia, Benedita. "Development and optimization of an experimental protocol to determine the impact of early-life microbiota on the immune system.". Paper presented in IJUP-Encontro de Investigação Jovem da Universidade do Porto, 2022.
  21. Maria Inês Magalhães; Maria Joaão Azevedo; Castro, Flávia; Maria Jose Oliveira; Angela M Costa; Sampaio-Maia, Benedita. "Impact of maternal obesity in early-life microbiota immune system priming – a preliminary study.". Paper presented in Microbiology Lab National Day- Pharmacy Faculty of Porto University, 2022.
  22. Catarina Moreira-Barbosa ; Carmen Ghilardi ; Alessandra Decio; Canha-Borges, Ana; Flávia Couto Brandão Pereira; Angela M Costa; Raffaella Giavazzi; Maria Rosa Bani; Maria Jose Oliveira. "PGC-1a and PGC-1ß as players in ovarian cancer: tumor-host crosstalk.". Paper presented in EACR 2022 Congress, 2022.
  23. Wilton, Joana; Filipa Lopes-Mendonça; Michael Tellier; Takayuki Nojima ; Isabel Pereira-Castro; Angela M Costa; Freitas, Jaime; et al. "Pro-inflammatory polarization induces 3’UTR shortening and intronic polyadenylation in primary human macrophages". Paper presented in EMBO Workshop: RNA 3' end formation and the regulation of eukaryotic genomes, 2022.
  24. Angela M Costa; Anas Rita Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Pereira, Luisa; Maria Jose Oliveira. "Unravel the hypoxia role on immunomodulation at the colon cancer microenvironment: a focus on macrophages.". Paper presented in HypoxEU 2022, 2022.
  25. Ferreira, Sara; Angela M Costa; Rios, Elisabete; Canão, Pedro Amoroso; Carneiro, Fatima; Maria Jose Oliveira; Cardoso, Ana Patrícia. "Colorectal cancer patient-derived scaffolds as tools to study the role of the extracellular matrix on cancer stemness and immunogenicity". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  26. Ferreira, Sara; Angela M Costa; Rios, Elisabete; Canão, Pedro Amoroso; Carneiro, Fatima; Maria Jose Oliveira; Cardoso, Ana Patrícia. "Colorectal cancer patient-derived scaffolds as tools to study the role of the extracellular matrix on cancer stemness and immunogenicity". Paper presented in EACR 2022 Congress, 2022.
  27. Wilton, Joana; Tellier, Michael; Nojima, Takayuki; Isabel Pereira-Castro; Freitas, Jaime; Angela Amorim-Costa; Murphy S; et al. "SRSF12 and cancer cells modulate macrophage alternative polyadenylation". Paper presented in RNA Meeting, 2021.
  28. Oliveira, Rosa; Martins, Flávia; Cavadas, Bruno; Pinto, Filipe; Cardoso AP; Castro, Flávia; Angela Margarida Costa. "Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions.". Paper presented in XXVI Porto Cancer Meeting, 2019.
  29. Oliveira, Rosa; Martins, Flávia; Cavadas, Bruno; Pinto, Filipe; Cardoso, AP; Castro, Flávia; Angela Margarida Costa. "Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions". Paper presented in XLV Annual Meeting of Portuguese Immunology Society, 2019.
  30. Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, AP; Castro, Flávia; Angela Margarida Costa. "Hypoxia alters colon cancer macrophage-cancer cell interactions". Paper presented in SICR 2019 – Symposium on Immunomodulation in Cancer & Regeneration, 2019.
  31. Angela Margarida Costa; Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, AP; Castro, Flávia; et al. "Modulation of macrophage-cancer cell interaction by the hypoxic colon cancer microenvironment". Paper presented in I ASEICA-ASPIC International Meeting, 2019.
  32. Oliveira, Rosa; Martins, Flávia; Castro, Flávia; Cardoso, AP; Oliveira MJ; Angela Margarida Costa. "Unravel the role of hypoxia at the tumor microenvironment: a focus on macrophage-cancer cell interplay". Paper presented in 7th i3S Annual Meeting, 2018.
  33. Martins, Flávia; Oliveira, Rosa; Pinto, Filipe; Castro, Flávia; Cardoso, AP; Cavadas, Bruno; Angela Margarida Costa. "The importance of considering hypoxia on the macrophage-cancer cell cross-talk". Paper presented in XXV Porto Cancer Meeting, 2018.
  34. Martins, Flávia; Oliveira, Rosa; Pinto, Filipe; Castro, Flávia; Cardoso, AP; Cavadas Bruno; Angela Margarida Costa. "The importance of considering hypoxia on the macrophage-cancer cell cross-talk". Paper presented in 3rd Aspic International Congress, 2018.
  35. Wilton J; Freitas, Jaime; Pereira-Castro, I.; Angela Margarida Costa; Castro, Flávia; Oliveira, MJ; Moreira, Alexandra. "Don’t shoot the messenger: RNA at the center of unraveling mechanisms of gene regulation in the cancer-macrophage microenvironment". Paper presented in ICMS-International Cancer Microenvironment Society Conference, 2018.
  36. Martins, Flávia; Pinto ML; Silva AJ; Sousa, Barbara; Oliveira, MJ; Angela Margarida Costa. "The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay". Paper presented in IJUP-Encontro de Investigação Jovem da Universidade do Porto, 2017.
  37. Martins, Flávia; Pinto ML; Silva AJ; Castro, Flávia; Oliveira, MJ; Angela Margarida Costa. "The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay". Paper presented in SICR2017 – Symposium on Immunomodulation in Cancer & Regeneration, 2017.
  38. Wilton J; Pereira-Castro, I.; Freitas, Jaime; Angela Margarida Costa; Castro, Flávia; Oliveira, MJ; Moreira, Alexandra. "Mechanisms of gene regulation in the crosstalk of the cancer – macrophage microenvironment". Paper presented in SICR2017 – Symposium on Immunomodulation in Cancer & Regeneration,, 2017.
  39. Martins, Flávia; Pinto ML; Silva AJ; Castro, Flávia; Oliveira, MJ; Angela Margarida Costa. "The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay". Paper presented in YES Meeting, 2017.
  40. Silva VAO; Angela Margarida Costa; Preto, Ana; Tansini, A.; Jordan P; Reis RM. "Role of WNK2 on glioma cell death mechanism". Paper presented in 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology-SBBq, 2015.
  41. Silva VAO; Angela Margarida Costa; Preto, Ana; Tansini, A.; Jordan P; Reis RM. "Role of WNK2 on glioma cell death mechanism". Paper presented in 5th International Symposium on Translational Oncology of the Barretos Cancer Hospital, 2015.
  42. Pinto, Filipe; Angela Margarida Costa; Lopes C; Crespo I; Andrade RP; Reis RM. "Loss of Brachyury expression is a negative prognostic factor that promotes glioma stem cell-like phenotype and invasiveness". Paper presented in São Paulo Advanced School in Oncogenesis and Translational Medicine, 2014.
  43. Angela Margarida Costa; Ferreira RM; Carneiro, F; Leite,M; Figueiredo, C. "Helicobacter pylori CagA-positive strains activate matrix metalloproteinase-10 in gastric cells via ERK and JNK pathways". Paper presented in São Paulo School of Advanced Science – Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment,, 2013.
  44. Silva VAO; Rosa MN; Tansini A; Angela Margarida Costa; Oliveira RSJ; Martinho Olga; Jones, C.; Pianowski, L.F.; Reis RM. "The semi-synthetic ingenol C derived from Euphorbia tirucalli induces cell death via autophagy but not apoptosis in human glioma cancer cells". Paper presented in 3rd Luso-Brazilian Congress of Experimental Pathology, 2013.
  45. Angela Margarida Costa; Oliveira, MJ; Martinho, Olga; Pinto, Filipe; Jordan P; Reis RM. "WNK2 as a modulator of MMP-2 and MMP-9 expression and activity in gliomas.". Paper presented in 6th Congress of the National Association of Neuro-oncology, 2013.
  46. Angela Margarida Costa; Ferreira RM; Carneiro, F; Leite,M; Figueiredo, C. "Helicobacter pylori CagApositive strains activate matrix metalloproteinase-10 in gastric cells via ERK and JNK pathways". Paper presented in 25th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, 2012.
  47. Angela Margarida Costa; Oliveira, MJ; Churin Y; Ferreira RM; Leite,M; Meyer TF; Figueiredo, C. "Molecular mechanisms underlying Helicobacter pylori-mediated host cell invasive phenotype". Paper presented in i3S retreat, 2011.
  48. Angela Margarida Costa; Oliveira, MJ; Churin Y; Ferreira RM; Leite,M; Meyer TF; Figueiredo, C. "Molecular mechanisms underlying Helicobacter pylori-mediated host cell invasive phenotype". Paper presented in 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, 2011.
  49. Angela Margarida Costa; Oliveira, MJ; Churin Y; Ferreira RM; Leite,M; Meyer TF; Figueiredo, C. "Nck, PLC-g, and c-Src are involved in Helicobacter pylori-mediated host cell invasion in a c- Met-dependent manner.". Paper presented in 24th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, 2011.
  50. Angela Margarida Costa; Oliveira, MJ; Costa, AC; Ferreira RM; Sampaio Paula; Machado JC; Seruca R; Mareel, M.. "CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-mediated cell invasive phenotype.". Paper presented in 16th National Congress of Biochemistry, 2008.
  51. Oliveira, MJ; Angela Margarida Costa; Costa, AC; Suriano, G.; Machado JC; Seruca, R.; Mareel, M.. "The E-cadherin/catenin complex suppresses Helicobacter pylori-mediated cancer cell invasion". Paper presented in Digestive Disease Week (DDW), 2007.
  52. Costa, AC; Ferreira RM; De Bruyne G; Angela Margarida Costa; Oliveira, MJ; Atherton, J.; Mareel, M.; Figueiredo, C. "Helicobacter pylori delocalizes tight junction molecules". Paper presented in 20th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, 2007.
  53. Lima Jorge; Feijão T; Pereira-Castro, I.; Angela Margarida Costa; Maximo V; Herrero, A.; Sobrinho-Simões M; García-Rostán, G.; Suarez C. "High frequency of germline SDHB and SDHD mutations in apparently sporadic head and neck paragangliomas from Spain". Paper presented in 7th Congress of the European Skull Base Society, 2005.
Journal article
  1. Marques-Magalhães, Ângela; Monteiro-Ferreira, Sara; Canão, Pedro Amoroso; Rios, Elisabete; Angela Margarida Costa; Castro, Flávia; Velho, Sérgia; et al. "Patient-Derived Colorectal Cancer Extracellular Matrices Modulate Cancer Cell Stemness Markers". International Journal of Molecular Sciences 26 7 (2025): 2890. https://doi.org/10.3390/ijms26072890.
    10.3390/ijms26072890
  2. Castro, Flávia; Pinto, Marta Laranjeiro; Leite Pereira, Catarina; Serre, Karine; Angela Margarida Costa; Cavadas, Bruno; Barbosa, Mário Adolfo; et al. "Chitosan/¿-PGA nanoparticles and IFN-¿ immunotherapy: A dual approach for triple-negative breast cancer treatment". Journal of Controlled Release 379 (2025): 621-635. https://doi.org/10.1016/j.jconrel.2025.01.042.
    10.1016/j.jconrel.2025.01.042
  3. Maria Inês Magalhães; Maria João Azevedo; Flávia Castro; Maria José Oliveira; Benedita Sampaio Maia; Angela Margarida Costa. "The link between obesity and the gut microbiota and immune system in early-life". Critical Reviews in Microbiology (2024): https://doi.org/10.1080/1040841X.2024.2342427.
    10.1080/1040841X.2024.2342427
  4. Diogo Estêvão; Miguel da Cruz-Ribeiro; Ana P. Cardoso; Ângela M. Costa; Maria J. Oliveira; Tiago L. Duarte; Tânia B. da Cruz. "Iron metabolism in colorectal cancer: a balancing act". Cellular Oncology (2023): https://doi.org/10.1007/s13402-023-00828-3.
    10.1007/s13402-023-00828-3
  5. Silveira, Maria José; Martins, Cláudia; Cruz, Tânia; Castro, Flávia; Angela Margarida Costa; Chester, Kerry; Oliveira, Maria José; Sarmento, Bruno. "scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells". Journal of Nanobiotechnology 21 1 (2023): http://dx.doi.org/10.1186/s12951-023-02126-4.
    10.1186/s12951-023-02126-4
  6. Wilton, Joana; de Mendonça, Filipa Lopes; Pereira-Castro, Isabel; Tellier, Michael; Nojima, Takayuki; Costa, Angela M.; Freitas, Jaime; et al. "Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1182525.
    10.3389/fimmu.2023.1182525
  7. Marques-Magalhães, Ângela; Cruz, Tânia; Angela Margarida Costa; Estêvão, Diogo; Rios, Elisabete; Canão, Pedro Amoroso; Velho, Sérgia; et al. "Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds for Studying Tumor-Stroma Interactions". Cancers 14 2 (2022): 359. http://dx.doi.org/10.3390/cancers14020359.
    10.3390/cancers14020359
  8. Cardoso, Ana Patrícia; Pinto, Marta Laranjeiro; Castro, Flávia; Costa, Ângela Margarida; Marques-Magalhães, Ângela; Canha-Borges, Ana; Cruz, Tânia; Velho, Sérgia; Oliveira, Maria José. "The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment". Cytokine & Growth Factor Reviews 60 (2021): 107-119. http://dx.doi.org/10.1016/j.cytogfr.2021.03.005.
    10.1016/j.cytogfr.2021.03.005
  9. Pinto, Filipe; Costa, Ângela M.; Andrade, Raquel P.; Reis, Rui Manuel. "Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide". Neurotherapeutics (2020): http://dx.doi.org/10.1007/s13311-020-00911-9.
    10.1007/s13311-020-00911-9
  10. Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, Ana Patrícia; Castro, Flávia; Sousa, Bárbara; et al. "Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer". Cancers 12 4 (2020): 818. http://dx.doi.org/10.3390/cancers12040818.
    10.3390/cancers12040818
  11. Pinto, Filipe; Costa, Ângela Margarida; Santos, Gisele Caravina; Matsushita, Marcus Medeiros; Costa, Sandra; Silva, Viviane Aline Oliveira; Miranda-Gonçalves, Vera; et al. "The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas". The Journal of Pathology (2020): http://dx.doi.org/10.1002/path.5419.
    10.1002/path.5419
  12. Alves, Ana Laura Vieira; Costa, Angela Margarida; Martinho, Olga; da Silva, Vinicius Duval; Jordan, Peter; Silva, Viviane Aline Oliveira; Reis, Rui Manuel. "WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line". Cells 9 2 (2020): 485. http://dx.doi.org/10.3390/cells9020485.
    10.3390/cells9020485
  13. Pereira, Márcia Santos; Celeiro, Sónia Pires; Costa, Ângela Margarida; Pinto, Filipe; Popov, Sergey; de Almeida, Gisele Caravina; Amorim, Júlia; et al. "Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2". Cellular Oncology 43 1 (2019): 107-121. http://dx.doi.org/10.1007/s13402-019-00475-7.
    10.1007/s13402-019-00475-7
  14. Silva, V.A.O.; Rosa, M.N.; Miranda-Gonçalves, V.; Costa, A.M.; Tansini, A.; Evangelista, A.F.; Martinho, O.; et al. "Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells". Investigational New Drugs 37 2 (2019): 223-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048839289&partnerID=MN8TOARS.
    10.1007/s10637-018-0620-y
  15. Carvalho, P.D.; Guimarães, C.F.; Cardoso, A.P.; Mendonça, S.; Costa, Â.M.; Oliveira, M.J.; Velho, S.. "KRAS oncogenic signaling extends beyond cancer cells to orchestrate the microenvironment". Cancer Research 78 1 (2018): 7-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040196244&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-17-2084
  16. Costa, A.M.; Mergulhão, F.J.; Briandet, R.; Azevedo, N.F.. "It is all about location: How to pinpoint microorganisms and their functions in multispecies biofilms". Future Microbiology 12 11 (2017): 987-999. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028548191&partnerID=MN8TOARS.
    10.2217/fmb-2017-0053
  17. Carvalho-Dias, E.; Miranda, A.; Martinho, O.; Mota, P.; Costa, Â.; Nogueira-Silva, C.; Moura, R.S.; et al. "Serotonin regulates prostate growth through androgen receptor modulation". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85034114043&partnerID=MN8TOARS.
    10.1038/s41598-017-15832-5
  18. Costa, A.M.; Ferreira, R.M.; Pinto-Ribeiro, I.; Sougleri, I.S.; Oliveira, M.J.; Carreto, L.; Santos, M.A.; et al. "Helicobacter pylori activates matrix metalloproteinase 10 in gastric epithelial cells via EGFR and ERK-mediated pathways". Journal of Infectious Diseases 213 11 (2016): 1767-1776. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978646526&partnerID=MN8TOARS.
    10.1093/infdis/jiw031
  19. Costa, A.M.; Pinto, F.; Martinho, O.; Oliveira, M.J.; Jordan, P.; Reis, R.M.. "Silencing of WNK2 is associated with upregulation of MMP2 and JNK in gliomas". Oncotarget 6 3 (2015): 1422-1434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922691567&partnerID=MN8TOARS.
  20. Costa, A.M.; Leite, M.; Seruca, R.; Figueiredo, C.. "Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori". FEBS Letters 587 3 (2013): 259-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872942923&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.12.008
  21. Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta - Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.
    10.1016/j.bbcan.2012.05.002
  22. Costa, A.M.; Oliveira, M.J.; Costa, A.C.; Ferreira, R.M.; Sampaio, P.; Machado, J.C.; Seruca, R.; Mareei, M.; Figueiredo, C.. "CagA associates with c-met, E-cadherin, and p120catenin in a multiproteic complex that suppresses helicobacter pylori-induced cell-invasive phenotype". Journal of Infectious Diseases 200 5 (2009): 745-755. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649120160&partnerID=MN8TOARS.
    10.1086/604727
  23. Costa, A.M.; Herrero, A.; Fresno, M.F.; Heymann, J.; Alvarez, J.A.; Cameselle-Teijeiro, J.; García-Rostán, G.. "BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma". Clinical Endocrinology 68 4 (2008): 618-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-40749104889&partnerID=MN8TOARS.
    10.1111/j.1365-2265.2007.03077.x
  24. Oliveira, M.J.; Costa, A.C.; Costa, A.M.; Henriques, L.; Suriano, G.; Atherton, J.C.; Machado, J.C.; et al. "Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner". Journal of Biological Chemistry 281 46 (2006): 34888-34896. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845953709&partnerID=MN8TOARS.
    10.1074/jbc.M607067200
  25. García-Rostán, G.; Costa, A.M.; Pereira-Castro, I.; Salvatore, G.; Hernandez, R.; Hermsem, M.J.A.; Herrero, A.; et al. "Mutation of the PIK3CA gene in anaplastic thyroid cancer". Cancer Research 65 22 (2005): 10199-10207. http://www.scopus.com/inward/record.url?eid=2-s2.0-28544452359&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-04-4259
Thesis / Dissertation
  1. Angela Margarida Costa. "Exploring the relationship between Helicobacter pylori and host cell invasion: from phenotypes to molecular mechanisms". PhD, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09/24 KRT17 e TPSAB1/B2 estão envolvidas na modulação do microambiente de cancro do cólon mediada pela hipóxia 6º ENJIO - ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA
Liga Portuguesa Contra o Cancro
2024/04/16 KRT17 and TPSAB1/B2 are involved in hypoxia-driven immunomodulation at the colon cancer microenvironment 5th Symposium on Immunomodulation in Cancer & Regeneration
Sociedade Portuguesa de Imunologia
2023 Impact of maternal obesity on early-life microbiota-induced immune system priming. IJUP-Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto (Porto, Portugal)
2023 SLC11A2 (DMT1) expression is downregulated by macrophagic infiltration at right colon tumors. 1st Symposium on Iron Metabolism and Cancer
i3S (Porto, Portugal)
2019 Unravel the role of hypoxia at the tumor microenvironment: a focus on macrophage-cancer cell interplay 12th IJUP Edition, Encontro de Investigação Jovem
Universidade do Porto (Porto, Portugal)
2019 Dissecting the role of CCL18 at the colorectal tumor microenvironment XLV Annual Meeting of Portuguese Immunology Society
(Coimbra, Portugal)
2019 Adrenergic control of human macrophages polarization and its putative impact in cancer progression. 12th IJUP Edition, Encontro de Investigação Jovem
(Porto, Portugal)
2018 The hypoxia impact in the macrophage-driven cancer cell invasive phenotype ICMS-International Cancer Microenvironment Society Conference
(Lisbon, Portugal)
2018 The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay. 11th IJUP Edition, Encontro de Investigação Jovem
(Porto, Portugal)
2018 Don’t shoot the messenger: mRNA at the center of gene regulation in the tumour – macrophage microenvironment. 7th i3S Annual Meeting
(Póvoa de Varzim, Portugal)
2018 Understanding the role of KRAS hotspot mutations in the regulation of the p16INK4a/KRAS/Galectin-3 axis in colorectal cancer 11th IJUP Edition, Encontro de Investigação Jovem
(Porto, Portugal)
2017 Understanding the role of KRAS hotspot mutations in the regulation of the p16INK4a/KRAS/Galectin-3 axis in colorectal cancer 6th i3S Annual Meeting
(Póvoa de Varzim, Portugal)
2017 The role of the hypoxic tumor microenvironment on macrophages 6th i3S Annual Meeting
(Póvoa de Varzim, Portugal)
2017 The impact of hypoxia in the macrophage-driven cancer cell invasive phenotype. 6th i3S Annual Meeting
(Póvoa de Varzim, Portugal)
2010 Helicobacter pylori disturbs gastric epithelial tight junctions in an inflammation-independent manner. 23rd International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
(Rotterdam, Netherlands)
2010 Helicobacter pylori and host interactions: contributions for disease pathogenesis i3S retreat
(Póvoa de Varzim, Portugal)
2009 AGS Cells expressing E-cadherin establish tight junctions and constitute a useful model for studying Helicobacter pylori infection. 22nd International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
(Porto, Portugal)
2008 CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-mediated cell invasive phenotype. 16th National Congress of Biochemistry
(São Miguel, Azores, Portugal)
2008 Ecadherin and CagA associate in a tetrameric complex that suppresses Helicobacter pylori-mediated cell invasion. 21st International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation
(Riga, Latvia)
2008 Ecadherin and CagA associate in a tetrameric complex that suppresses Helicobacter pylori-mediated cell invasion Digestive Disease Week (DDW) – American Gastroenterological Association
(San Diego, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - 2024/10/30 Colon cancer and immune cells interactions: the role of hypoxia
Supervisor of Maria Lapa de Barros Peixoto
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09/01 - 2022 The role of hypoxia on immunomodulation at the colon cancer microenvironment
Supervisor of Ana Rita Fialho Santos
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07/01 - 2022 Impact of maternal obesity on early-life microbiota-induced immune system priming
Co-supervisor of Maria Inês Magalhães
 Microbiologia Aplicada
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2017/10/01 - 2018/12/08 Unravel the role of hypoxia in the tumor microenvironment: a focus on macrophage-cancer cell interplay
Supervisor of Rosa Alexandra Costa Oliveira
 Genética Molecular (Master)
Universidade do Minho Escola de Ciências, Portugal
2016/10/01 - 2017/12/04 The role of the hypoxic microenvironment on the macrophage-tumor cell interplay
Supervisor of Flávia Oliveira Martins
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/19 The impact of Leishmania infection on the migratory behaviour of host macrophages
(Thesis) Main arguer
 Mafalda Sofia Mendonça de Castro (Master)
Universidade de Aveiro, Portugal
2021/09/24 Sympathetic Innervation in Breast Cancer Bone Metastasis: Exploring the role of alpha2C-adrenergic signaling pathway in the bone metastatic niche
(Thesis) Main arguer
 Ana Lúcia Silva Fonseca (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/12/16 Functional role of the small leucine rich repeat proteoglycan (SLRP) biglycan in gastric cancer
(Thesis) Main arguer
 Liliana Manuela Santos Ferreira (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/05/16 Dissecting chemotherapy resistance in prostate cancer: interplay between RKIP and androgen stimulation
(Thesis) Main arguer
 Inês Fernandes Lages (Master)
Universidade do Minho Escola de Medicina, Portugal
2019/03/01 In vitro analysis of novel chemical compounds for the treatment of lung cancer
(Thesis) Main arguer
 Ana Carina Gomes Cerqueira (Master)
Universidade do Minho Escola de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/04/19 - Current Cellular & Molecular Biology Letters Springer Nature
2021 - Current Frontiers in Bioscience-Landmark IMR Press
2021 - Current Brazilian Journal of Medical and Biological Research (1414-431X) Associação Brasileira de Divulgação Científica (ABDC)

Association member

Society Organization name Role
2023 - Current ANICT Member
2016/06/01 - Current ASPIC-Associação Portuguesa de Investigação em Cancro Member
2016/06/01 - Current EACR-European Association for Cancer Research Member
2015/10/01 - Current SPI-Sociedade Portuguesa de Imunologia Member
2006/06/01 - Current ABIC-Associação de Bolseiros de Investigação Científica Member

Conference scientific committee

Conference name Conference host
2021/11/30 - 2021/11/30 4th PhDay: Break borders and build opportunities i3S - Instituto de Investigação e Inovação em Saúde

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/08 - 2024/08 Ocupação Científica de Jovens nas Férias 2024-Ciência Viva (Ensino secundário) Ciência Viva, Portugal
2013/02/25 - 2013/02/28 International Postgraduate Programme Course: "An integrative approach to cell analysis: cell and tissue culture, flow cytometry and microscopy"- Pratical session (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/03/14 - 2012/03/31 Basic Course of Molecular Pathology with emphasis in Infection in Oncology - Practical session (Pós-Graduação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2006/06/01 - 2006/08/31 “Ciência Viva” (Ensino secundário) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/05/06 - 2024/05/08 Oral Presentations Evaluation of IJUP-Encontro de Investigação Jovem
Evaluator
 Universidade do Porto, Portugal
2021/07/14 - 2024 External Member of the Evaluation Committee at the Biomedical Engineering Doctoral Program, FEUP
Evaluator
 Universidade do Porto Faculdade de Engenharia, Portugal
2021/06/17 - 2024 External Member of the Evaluation Committee at the Health Sciences Doctoral Program, ICVS
Evaluator
 Universidade do Minho Escola de Medicina, Portugal
2021/11 - 2021/11 Oral presentations Evaluation of 4th PhDay: Break borders and build opportunities
Evaluator
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/06/18 - 2021/07/01 External evaluator of the Research Techniques curricular unit of the Doctoral Program in Biomedical Engineering, FEUP
Evaluator
 Universidade do Porto Faculdade de Engenharia, Portugal
2021 - 2021 Abstracts Evaluation of iMed Conference 13.0| Innovate Competition
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2019 Posters Evaluation in IJUP-Encontro de Investigação Jovem, Poster evaluation
Evaluator
 Universidade do Porto, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020 The interview was about the First nCounter Tumor Signaling 360 Panel Grant Award, and the work that I will be able to do in the area of colon cancer molecular mechanisms. Notícias Universidade do Porto
2020 The interview was about the First nCounter Tumor Signaling 360 Panel Grant Award, and the work that I will be able to do in the area of colon cancer molecular mechanisms, as well as my career path. Jornal O Minho

Interview (tv / radio show)

Program Topic
2019 - Current Interview for TSF Radio commenting the The Nobel Prize in Physiology or Medicine 2019, recognizing the importance of the seminal work in the hypoxia area. The Nobel Prize in Physiology or Medicine 2019

Mentoring / Tutoring

Topic Student name
2024/03 - 2024/03 Higher Technical and Professional Course in Cultures and Laboratory Maintenance- Health School of the Porto Polytechnic Institute Paula Catarina Andrade Pinto
2023 - 2024 Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds for Studying Tumor-Stroma Interactions Ângela Magalhães
2022 - 2024 Immunomodulatory nanomedicine for colorectal cancer treatment Maria José Silveira
2023 - 2023 Combinational therapeutic strategies to improve the efficacy of immune-checkpoint inhibitors in endometrial cancer Pedro Novais
2021 - 2022 PGC-1a and PGC-1ß as players in ovarian cancer: tumor-host crosstalk Catarina Barbosa
2019 - 2021 RNA at the center of unraveling mechanisms of gene regulation in the cancer-macrophage microenvironment Joana Wilton
2017 - 2018 Adrenergic control of human macrophages polarization and its putative impact in cancer progression. Diogo Adão
2017 - 2018 Targeting metastatic colorectal cancer with PLGA nanoparticles carrying MACC1 siRNA Rita Sousa
2016 - 2017 Understanding the role of KRAS hotspot mutations in the regulation of the p16INK4a/KRAS/Galectin-3 axis in colorectal cancer Flávia Pereira
2015 - 2016 In vitro characterisation of macrophage- colorectal/gastric cancer cell crosstalk. Ana João Silva
2012 - 2014 The role of T-box transcription factor brachyury in gliomas Filipe Pinto
2012 - 2013 The role of SPINT2 in gliomas Márcia Pereira
2007 - 2008 The Helicobacter pylori impact on tight junctions Marta Laranjeiro Pinto
2006 - 2007 The study of Helicobater pylori virulence factors Rui Ferreira
Distinctions

Award

2024 Best Poster Award at 17th IJUP - Health Sciences
Universidade do Porto, Portugal
2020 First nCounter Tumor Signaling 360 Panel Grant Program
NanoString Technologies Inc Europe, United Kingdom
2019 Best Poster Award- SICR2019
2017 Best Poster Award of SICR2017
2015 Best Poster Award in the 5th International Symposium on Translational Oncology of the Barretos Cancer Hospital
2015 Best Poster Award in 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology-SBBq
2013 Honorable Mention in the Poster Award of the III Luso-Brazilien Congress of Experimental Pathology
2011 Best Poster Award in Infection Biology- i3S Retreat
2011 Travel Grant for "36th FEBS Congress, Biochemistry for Tomorrow's Medicine", June 25-30, 2011, Torino, Italy
Federation of European Biochemical Societies, United Kingdom
2006 1st Award LabMed
2005 Best poster Award at the 7th Congress of the European Skull Base Society