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I have a degree in Bioengineering and a master's degree in Biotechnology for Health Sciences from the University of Trás-os-Montes e Alto Douro, where I developed a strong interdisciplinary background in molecular and cell biology, biochemistry, health sciences, and bioinformatics, complemented by programming skills in C and basic knowledge of Python. Using C. elegans as a model organism, I studied Machado-Joseph disease in my master's thesis, focusing on the LGC-50 serotonin receptor and its possible similarity to the human 5-HT3 receptor. This study combined molecular and biochemical techniques, such as Western blot, CRISPR-Cas9 genome editing, and genetic crosses in C. elegans, with bioinformatic studies to investigate the structural and functional characteristics of the receptor. Furthermore, I optimized a Python-based software tool originally designed for C. elegans, which calculates multiple metrics such as animal size, average speed, and maximum speed. I adapted it to the specific requirements of the laboratory environment, enabling a more accurate assessment of movement differences between wild-type animals and genetically modified strains generated during the thesis. Through these experiences, I gained hands-on expertise in experimental design, statistical analysis, data analysis, and computational tool development, which not only reinforced my interest in neurodegenerative diseases, protein targets, and therapeutic strategy development but also equipped me with the scientific and technical skills required to contribute effectively to multidisciplinary research in areas such as drug development, protein degradation, and disease modelling.
Identification

Personal identification

Full name
LÍDIA DANIELA CARVALHO NUNES
Date of birth
2000/05/16
Gender
Female

Citation names

  • Lídia Nunes-Carvalho
  • Lídia Nunes

Author identifiers

Ciência ID
D312-5FF1-8E96

Email addresses

  • lidianunes@outlook.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2023/09 - 2025/04/24
Concluded
Biotecnologia para as Ciências da Saúde (Mestrado integrado)
Major in Biotechnology for Health Sciences
Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade do Minho, Portugal
"Role of the serotonin receptor 5-HT3/LGC-50 in Spinocerebellar Ataxia type 3 pathogenesis: a C. elegans-based study. (Classification: 20)" (THESIS/DISSERTATION)
17
2023/09/19 - 2023/09/21
Concluded
Workshop - Python for Biologists: Beginners Level (Outros)
Major in Bioinformatics
Nano Science and Technology Consortium (NSTC), India
2018/09 - 2021/08
Concluded
Bioengenharia (Licenciatura)
Major in Engenharia Biológica e Tecnologia Ambiental
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
13
Outputs

Publications

Conference poster
  1. Lídia Nunes-Carvalho; Pereira-Sousa, Joana; Chaves, Raquel; Maciel, Patrícia; Teixeira-Castro, Andreia. "Role of the serotonin receptor 5-HT3/LGC-50 in the suppression of Spinocerebellar Ataxia type 3 (SCA3) pathogenesis". Paper presented in ICVS Retreat 2024, 2024.
  2. Costa, Marta Daniela; Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Vieira, Carmen; NUNES, LÍDIA; Teixeira-Castro, Andreia; Maciel, Patrícia. "Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease". Paper presented in Congress SPDMov 2024: Portuguese Society for Movement Disorders: Treatable Movement Disorders, 2024.
  3. Costa, Marta Daniela; Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Vieira, Carmen; NUNES, LÍDIA; Teixeira-Castro, Andreia; Maciel, Patrícia. "Novel genetic modifiers of MJD/SCA3: an EMS screening in a C. elegans model of the disease". Paper presented in International Congress for Ataxia Research 2024, 2024.
  4. Lídia Nunes-Carvalho; Pereira-Sousa, Joana; Chaves, Raquel; Maciel, Patrícia; Teixeira-Castro, Andreia. "Role of the serotonin receptor 5-HT3/LGC-50 in the suppression of Spinocerebellar Ataxia type 3 (SCA3) pathogenesis". Paper presented in International Congress for Ataxia Research 2024, 2024.
Activities

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/06/26 - 2025/06/27 Participated as attendee in the scientific retreat of the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, which included attending numerous seminars and scientific presentations related to health and biomedical research. ICVS Retreat 2025
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/07/25 - 2024/07/25 Provided support during the summer “Hands-on Workshop” on campus, aimed at engaging elementary and high school students with science and biomedical research. I was mainly involved in the practical demonstration and explanation of the experimental model Caenorhabditis elegans (C. elegans), emphasizing its use in neuroscience studies.
Other
Verão no Campus
Universidade do Minho Escola de Ciências da Saúde, Portugal
2024/07/04 - 2024/07/05 Participated as attendee in the scientific retreat of the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, which included attending numerous seminars and scientific presentations related to health and biomedical research.
Other
ICVS Retreat 2024
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/05/16 - 2024/05/16 I participated in an institutional short video highlighting the importance of being a scientist and what it means to pursue a scientific career, sharing my personal experience and perspective on science.
Other
Celebration of National Day of Scientists with an educational/engagement video shared on ICVS social media
Universidade do Minho Escola de Ciências da Saúde, Portugal
2024/03/11 - 2024/03/15 Participation in a roundtable discussion open to the community (with virtual transmission) on “Brain and Neurodiversity,” and in hands-on outreach activities for kindergarten and primary school children aimed at introducing the institute and raising interest in neuroscience. My contribution focused on science outreach by demonstrating and explaining the experimental model Caenorhabditis elegans (C. elegans) as a tool for studying the nervous system.
Other
Brain Awareness Week
Universidade do Minho Escola de Ciências da Saúde, Portugal
2023/09/29 - 2023/09/29 Science divulgation activity for the general public.
Other
European Researchers’ Night 2023: "Discovering the Connections between Space and Human Health”.
Universidade do Minho Escola de Ciências da Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2024/04 - 2024/07 Role of the serotonin receptor 5HT3/LGC-50 in the suppression of SCA3 pathogenesis. Ana Rita Peixoto
2024/04 - 2024/07 Role of the serotonin receptors in SCA3 pathogenesis using Caenorhabditis elegans: generation of new genetic tools. Joana Ribeiro
2024/04 - 2024/06 Role of the serotonin receptor 5HT1A/SER-4 in the suppression of SCA3 pathogenesis: a C. elegans-based study Bruna Costa
2023/12 - 2024/03 Role of the ionotropic serotonin receptor in the suppression of SCA3 pathogenesis in Caenorhabditis elegans: generation of new genetic tools. Maria Castro