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Ana Luísa Ribeiro da Silva graduated in Biochemistry by the Faculty of Sciences of the University of Lisbon in 1998. After two years as a FCT Scientific Initiation Fellow at the Instituto Português de Oncologia (IPO, Lisbon), was FCT research fellow for an additional year at the Instituto Nacional de Saúde, Doutor Ricardo Jorge (INSA, Lisbon), where she consolidated her scientific training before perusing her PhD under the supervision of Dr. Luísa Romão ( INSA, Lisbon). In 2008 she received her PhD degree in Biochemistry and Molecular Genetics by the University of Lisbon and was awarded a Post-Doctoral fellowship by FCT, under the supervision of Dr. Margarida Amaral (FCUL, Lisboa) and Dr. Luísa Romão (INSA, Lisbon. Upon finishing her post-doc training in 2010, she expanded her research interests into the oncobiology field and I joined the Molecular Endocrinology group at the Instituto Português de Oncologia (IPO, Lisbon). At the beginning of 2016 had the opportunity to start her own independent research and integrated the Department of Endocrinology Diabetes and Metabolism in the Centro Hospitalar Universitário de Lisboa Norte EPE (CHULN) and the Ecogenetics and Human Health unit of the Instituto de Saúde Ambiental (ISAMB), a R&D centre at FMUL. Is also Invited Assistant Professor at Faculdade de Medicina da Universidade de Lisboa since 2021 and Invited Assistant Professor at Católica Medical Scholl, Universidade Católica Portuguesa since 2022 . Published 29 articles in journals. Has 2 sections of books. Organized 3 events. Co-supervised 1 PhD thesis. Supervised 11 MSc dissertations e co-supervised 1. Has received 10 awards and honors. Participates and participated as Scientific Initiation Fellow in 1 project, Research Fellow in 2 projects, PhD Student Fellow in 3 projects, Post-doc Fellow in 1 project, Post-doc researcher in 1 project and Principal investigator in 7 project. In her Ciência Vitae the most frequent terms in the context of scientific, output are: Gene Expression Regulation; mRNA; Translation; Nonsense Mediated mRNA Decay (NMD); Signaling Pathways; RAC1 and RAC1b; Oncobiology; Thyroid Carcinoma; Sodium Iodide Symporter (NIS); Health Sciences - Molecular and Genetic Medicine; Oncobiology; Cell Signalling.
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Identification

Personal identification

Full name
Ana Luísa Silva

Citation names

  • Silva, Ana Luísa

Author identifiers

Ciência ID
D215-714A-CA06
ORCID iD
0000-0002-4839-8279
Google Scholar ID
https://scholar.google.com/citations?user=U9pukm0AAAAJ&hl=pt-PT

Email addresses

  • silva.r.analuisa@gmail.com (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2024/09/02 - 2024/11/24
Concluded
 Postgraduate Advanced Course on Pituitary Tumors . MODULES I, II, III, IV, (Outros)
CUF, Portugal
2008
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Genética Molecular
Universidade de Lisboa Faculdade de Ciências, Portugal
"Mammalian Nonsense-mediated mRNA Decay: New Determinants That Make Transcripts Bearing a Small Open Reading Resistant to Rapid Decay" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
1998
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"RT-PCR - Based Detection of Molecular Markers for Acute Leukaemia - Diagnosis and Minimal Residual Disease Evaluation" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2024/09/01 - Current Researcher (Research) Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
Universidade Católica Portuguesa Faculdade de Medicina, Portugal
2016 - Current Researcher (Research) Universidade de Lisboa Instituto de Saúde Ambiental, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2010/11/01 - 2016/03/01 Researcher (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
iNOVA4Health, Portugal
2008/03/01 - 2010/10/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
(...)
2007/01/01 - 2008/01/31 Postdoc (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/09/01 - Current Assistant Professor (University Teacher) Universidade Católica Portuguesa Faculdade de Medicina, Portugal
Universidade Católica Portuguesa Faculdade de Medicina, Portugal
2022 - 2024/09/01 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa Campus Sintra, Portugal
2021/10/01 - 2024/09/01 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2016/05/01 - 2022/12/31 Técnico Superior (Técnico Superior) Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Universidade de Lisboa Instituto de Saúde Ambiental, Portugal
(...)

Others

Category
Host institution 		Employer
2002/10/01 - 2006/09/30 PhD student, FCT research fellow Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2001/03/01 - 2002/09/30 FCT Research Fellow Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
1999/03/01 - 2001/02/28 FCT Research Fellow Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
1997/09/01 - 1998/08/31 Undergraduate student Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Projects

Grant

Designation Funders
2008 - 2010 Controlo pós-transcricional da expressão da Hemojuvelina e o seu papel na homeostase do ferro.
SFRH/BDP/34583/2007
Post-doc Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2008 Study of the human alfa-globin nonsensemediated mRNA decay
POCTI/BIA-BCM/59140/2004
Research Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2006 Determinantes moleculares envolvidos na ativação do mecanismo de nonsense mediated mRNA decay (NMD) de transcritos da beta-globina humana portadora de mutações nonsense
SFRH / BD / 8351 / 2002
PhD Student Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2003 Study of the human beta-globin nonsense-mediated mRNA decay
info:eu-repo/grantAgreement/FCT/POCI/34105/PT
Research Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999/03/01 - 2001 Evaluation of minimal residual disease in hematopoietic products collected from patients with breast cancer submitted to autologens stem cell transplantion
info:eu-repo/grantAgreement/FCT/POCI/1395/PT
Scientific Initiation Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/01/01 - Current Role of CCL2 and IL-8 in pituitary neuroendocrine tumor microenvironment
NETRF 2021-Pilot Project Award
Co-Principal Investigator (Co-PI)
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
 Neuroendocrine Tumor Research Foundation
Ongoing
2021/02/01 - Current Arrest warrant for NIS at the plasma membrane: enhancing iodide uptake in refractory thyroid cancer
Limbert-2021
Principal investigator
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
 Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Ongoing
2018/10/01 - Current NISomics - Sodium-iodide symporter posttranslational interactome: identification of novel targets to enhance iodide-related cancer therapy
PTDC/BIA-MOL/31787/2017
Principal investigator
Universidade de Lisboa Instituto de Saúde Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2026/02/28 BrightFigs - Building a Brighter Future for Fluorescence Imaging Guided Surgery
2022.05950.PTDC
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2019 Interplay between NF-kB signaling and PI3K-Akt-mTOR pathway in Gastroenteropancreatic Neuroendocrine Tumors: a role for miR-21 and PTEN?
SPEDM/GETNE-2017
Principal investigator
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
 Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Concluded
2016 - 2018 RAC1/1b signaling in the modulation of NIS expression: potentiation of radioactive iodine therapy in follicular cell-derived thyroid carcinoma
LIMBERT-2016
Principal investigator
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
 Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Concluded
2014 - 2015 Unraveling Rac1b/BRAF V600E interplay in papillary thyroid carcinoma: a search for prognostic indicators
IPO-2014
Principal investigator
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE
Concluded
2012 - 2014 Rac1b overexpression and Thyroid Carcinoma Tumorigenesis
RAC1b_AEO2012
Principal investigator
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
 Associação de Endocrinologia Oncológica
Concluded
2012 - 2014 Testes de quimiosensibilidade em culturas celulares primárias de tumores da tiróide
LIMBERT2011
Principal investigator
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
 Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Concluded
2005 - 2007 Study of the mechanism by which the proximity of the nonsense codon to the AUG inhibits the nonsense-mediated mRNA decay
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82323/PT
PhD Student Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2005 Identification and characterization of cis-acting elements and trans-acting factors involved in the human ß-globin nonsense-mediated mRNA decay mechanism
POCTI/MGI/48296/2002
PhD Student Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Silva, Ana Luísa; Faria, Márcia; Matos, Paulo. "Inflammatory Microenvironment Modulation of Alternative Splicing in Cancer: A Way to Adapt". In Advances in Experimental Medicine and Biology, edited by Serpa, Jacinta, 243-258. Springer International Publishing, 2020.
    10.1007/978-3-030-34025-4_13
  2. Silva, Ana Luísa; Luísa Romao. "Controlo de Qualidade do RNA Mensageiro em Mamíferos: Mecanismos de Degradação". In O MUNDO DO RNA - NOVOS DESAFIOS E PERSPECTIVAS FUTURAS, edited by Cecília Arraiano; Arsénio Fialho. Portugal: Lidel, 2007.
    Published
Conference abstract
  1. Faria, Márcia; Domingues, Rita; João, Bugalho Maria; Matos, Paulo; Silva, Ana Luísa. "Targeting RAC1 signaling to potentiate the positive effect of MAPK pathway inhibition on radioiodine uptake". 2020.
    10.1530/endoabs.70.aep865
  2. Faria, Marcia; Matos, Paulo; Bugalho, Maria Joao; Silva, Ana Luisa. "Impact of RAC1/1b signalling on Sodium Iodide symporter regulation". 2017.
    10.1530/endoabs.49.ep1448
  3. Silva, Ana Luisa; Carmo, Francisca; Pereira, Teresa; Cabrera, Rafael Adame; Bugalho, Maria Joao. "Rac1B: a prognostic marker for papillary thyroid carcinoma?". 2013.
    10.1530/endoabs.32.p1079
Conference poster
  1. Vareda J, Miranda M, Faria M, Bugalho MJ, Matos P, Silva AL.. "A integridade das adesões célula-célula é um determinante chave para a expressão funcional de NIS.". Paper presented in Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, Vilamoura, Portugal., 2023.
  2. Faria M, Bugalho MJ, Matos P, Silva AL. "A role for RAC1 in the rescue of functional NIS expression at the plasma membrane induced by MEK inhibition.". Paper presented in ATAs 91st Annual Meeting, Palais des Congrès de Montréal, Montréal, Quebec, Canada, 2022.
  3. Faria M, Vareda J, Bugalho MJ, Silva AL, Matos P. "Identification of Sodium Iodine Symporter (NIS) interactome at the surface of thyroid cancer cells.". Paper presented in 5th ASPIC International Congress, IPO-Porto,Porto, Portugal., 2022.
  4. Alexandre MI, Domingues R, Matos T, Vale S, Ferreira J, Bicho M, Bugalho MJ, Silva AL. "Análise de polimorfismos no gene NLRP1 na Diabetes mellitus tipo1.". Paper presented in Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo,Vilamoura, Portugal., 2022.
  5. Faria M, Domingues R, Bugalho MJ, Matos P, Silva AL.. "MAPK e RAC1 exercem efeitos opostos na expressão de NIS em células de carcinoma da tiróide.". Paper presented in Congresso Português de Endocrinologia., 2022.
  6. Faria M, Domingues R, Bugalho MJ, Matos P, Silva AL.. "Modulação da expressão funcional de NIS: Uma comparação entre tecido tiroideu e mamário.". Paper presented in Congresso Português de Endocrinologia., 2022.
  7. Faria M, Domingues R, Bugalho MJ, Matos P, Silva AL.. "Um papel para a tirosina cinase SRC na expressão funcional de NIS na membrana plasmática.". Paper presented in Congresso Português de Endocrinologia, 2022.
  8. Alexandre, Maria Inês; Marçalo, J; Domingues, Rita; Silva, Ana Luísa; Bugalho, Maria João. "Hyperparathyroidism-Jaw Tumor Syndrome in a Patient With Colon Cancer: A Case Report". Paper presented in ENDO 2021, 2021.
  9. Márcia Faria; Rita Domingues; Daniela Félix; Maria João Bugalho; Paulo Matos; Silva, Ana Luísa. "Modulação combinada das vias de sinalização RAC1 e MAPK para potenciar a captação de iodo radioactivo.". Paper presented in Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, 2021.
  10. Faria, Márcia; Domingues, Rita; Paixão, Francisca; Bugalho, Maria João; Silva, Ana Luísa; Matos, Paulo. "TNFa Inhibits Sodium-Iodide Symporter Expression In Thyroid Cells Through Nf-¿b Activation". Paper presented in 24th Annual meeting of SPGH, 2020.
  11. Faria, Márcia (101c-8098-518f); Domingues, Rita; Felix, Daniela; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Modulação da expressão funcional de NIS: impacto das GTPases RAC1 e RAC1b.". Paper presented in Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, 23-26 Janeiro, Coimbra, Portugal., 2020.
  12. Faria, Márcia (101c-8098-518f); Felix, Daniela; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma". Paper presented in 89th Annual Meeting of the ATA of the American Thyroid Association, 2019.
  13. Faria, Márcia (101c-8098-518f); Paixão, Fancisca; Domingues, Rita; Brito, Denise; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Identificação de novos moduladores da abundância de NIS na membrana plasmática". Paper presented in Congresso Português de Endocrinologia, 24-27 Janeiro, Braga, Portugal., 2019.
  14. Faria, Márcia; Félix, Daniela; Domingues, Rita; Paixão, Francisca; Brito, Denise; Bugalho, Maria João; Silva, Ana Luísa. "Unraveling signaling pathways that modulate NIS functional regulation". Paper presented in 9 th Meeting on Signal Transduction, 2018.
  15. Faria, Márcia (101c-8098-518f); Silva, Ana Luísa. "Unravelling the Signaling Pathways Influencing the NIS regulation". Paper presented in 9th Meeting on Signal Transduction,, 2018.
  16. Márcia Faria; Domingues Rita (0B12-EF2F-133D); Matos, Paulo; Silva, Ana Luísa. "Modulation of Sodium Iodide Symporter expression by tumor-associated signaling pathways.". Paper presented in 3rd ASPIC International Congress, 2018.
  17. Dias, Joana; Domingues, Rita; Faria, Márcia (101c-8098-518f); Bugalho, Maria João; Silva, Ana Luísa. "Impacto do TNF-alpha na ativação de vias pró-proliferativas e de sobrevivência em linhas celulares de tiróide.". Paper presented in Congresso Português de Endocrinologia, Algarve, Portugal., 2018.
  18. Dias, Joana; Domingues, Rita; Faria, Márcia; Bugalho, Maria João; Silva, Ana Luísa. "Impacto do TNF-alfa na ativação de vias pró-proliferativas e de sobrevivência em linhas celulares de tiróide". Paper presented in Congresso Português de Endocrinologia, Vilamoura, Portugal, 2018.
  19. Faria, Márcia; Félix, Daniela; Capinha, Liliana; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Enhancing radioactive iodine therapy: a role for RAC1/1b signaling?". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, Lisbon, Portugal, 2017.
  20. Faria, Márcia (101c-8098-518f); Matos, Paulo; Bugalho, Maria João; Silva, Ana Luísa. "Impact of RAC1/1b signalling on Sodium Iodide symporter regulation". Paper presented in 19th European Congress of Endocrinology, Lisbon, Portugal., 2017.
  21. Faria, Márcia; Matos, Paulo; Bugalho, Maria João; Silva, Ana Luísa. "Impact of RAC1/1b signaling on Sodium Iodide symporter regulation". Paper presented in 19th European Congress of Endocrinology, 2017.
  22. Faria, Márcia (101c-8098-518f); Matos, Paulo; Pereira, Teresa; Cabrera, Rafael Adame; Cardoso, Bruno António; Bugalho, Maria João; Silva, Ana Luísa. "RAC1b overexpression in papillary thyroid carcinomas: an activator of NF-kB pathway that contributes to thyroid tumorigenesis?". Paper presented in 2nd ASPIC International Congress, 28-29 April, Oporto, Portugal., 2016.
  23. Silva, Ana Luísa; Carmo, Francisca; Moura, Margarida; Domingues, Rita; Espadinha, Carla; Leite, Valeriano; Cavaco, Branca; Bugalho, Maria João. "Functional characterization of two novel RET variants associated with medullary thyroid carcinoma". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal., 2014.
  24. Silva, Ana Luísa. "Rac1B: a prognostic marker for papillary thyroid carcinoma?". Paper presented in European Congress of Endocrinology (ECE) 2013 , Bella Centre, Copenhagen, Denmark., 2013.
  25. Silva, Ana Luísa. "Nonsense-mediated decay resistance of AUG-proximal nonsense-mutated transcripts relies on the link between translation initiation and premature stop codon definition.". Paper presented in EMBO Conference Series “Protein Synthesis and Translational Control”. EMBL Advanced Training Centre, Heidelberg, Germany., 2011.
  26. Peixeiro, I.; Barbosa, C; Silva, Ana Luísa; Romão, Luísa. "Interactions between 5’ and 3’ end-associated proteins during mRNA translation protects AUG-proximal nonsense-mutated mRNAs from nonsense-mediated decay.". Paper presented in Biochemical Society meeting on Post-transcriptional control: mRNA translation, localization and turnover. Edinburgh, UK., 2010.
  27. Pereira, F.J.C.; Silva, Ana Luísa; Romão, Luísa. "How the secondary structure of the open reading frame affects the efficiency of nonsense-mediated decay in transcripts with AUG-proximal nonsense codons. .". Paper presented in Biochemical Society meeting on Post-transcriptional control: mRNA translation, localization and turnover. Edinburgh, UK, 2010.
  28. Morgado, A.; Teixeira, Alexandre; Silva, Ana Luísa; Romão, Luísa. "Abnormal nuclear distribution of human beta-globin transcripts committed to nonsense-mediated mRNA decay, in erythoid cells.". Paper presented in Biochemical Society meeting on Post-transcriptional control: mRNA translation, localization and turnover. Edinburgh, UK., 2010.
  29. Morgado, Ana; Teixeira, Alexandre; Silva, Ana Luísa; Romão, Luísa. "Human beta-globin transcripts commited to nonsense-mediated mRNA decay have na abnormal nuclear distribution in erythoid cells.". Paper presented in EMBO Workshop on RNA Quality Control, Vienna, Austria., 2010.
  30. Martins, Rute; Proença, Daniela; Silva, Bruno; Silva, Ana Luísa; Faustino, Paula; Romão, Luísa. "Nonsense-mediated mRNA decay (NMD) plays a role in post-transcriptional regulation of human HFE expression". Paper presented in EMBO Workshop on RNA Quality Control, Vienna, Austria., 2010.
  31. Pereira, Francisco J.C.; Silva, Ana Luísa; Romão, Luísa. "The secondary structure of the short open reading frame affects the extension of the AUG-proximity effect on nonsense-mediated mRNA decay". Paper presented in EMBO Workshop on RNA Quality Control, Vienna, Austria., 2010.
  32. "Martins, Rute"; Proença, D.; Silva, B.; Silva, A.L.; Paula Faustino; Romão, L.; Martins, Rute; et al. "Nonsense-mediated mRNA decay (NMD) plays a role in post-transcriptional regulation of human HFE gene expression". Paper presented in EMBO Workshop “RNA Quality Control”, 10-13th May, Vienna, Austria., 2010.
  33. Pereira, Francisco J.C.; Kong, Jian; Silva, Ana Luísa; Liebhaber, Stephen A.; Romão, Luísa. "The extention of the AUG-proximity effect on nonsense-mediated mRNA decay inhibition is modulated by the secondary structure of a short open reading frame in human alpha- and beta-globin transcripts". Paper presented in Vth National Meeting on RNA Biology, Carcavelos, Portugal., 2009.
  34. Peixeiro, Isabel; Barbosa, Cristina; Silva, Ana Luísa; Romão, Luísa. "PABPC1 protects AUG-proximal nonsense-mutated mRNAs from nonsense-mediated mRNA decay". Paper presented in EMBO Workshop on Messenger RNA 3’ ends and gene expression, Brasenose College University of Oxford, Oxford, UK., 2009.
  35. Silva, Ana Luísa; Inácio, Ângela; Peixeiro, Isabel; Romão, Luísa. "A role for PABPC1 on mammalian nonsense-mediated mRNA decay". Paper presented in EMBO Conference on RNA and Disease, Villa Mondragone, Rome, Italy., 2008.
  36. Inácio, Ângela; Ramos, Ana; Silva, Ana Luísa; Romão, Luísa. "The translation termination reaction at an AUG-proximal stop codon appears to be as efficient as that at a normal termination codon". Paper presented in RNA 2008 - 13th Annual Meeting of the RNA Society , Berlin, Germany., 2008.
  37. Martins, Rute; Silva, Ana Luísa; Proença, Daniela; Silva, Bruno; Faustino, Paula; Romão, Luísa. "Is the HFE expression regulated by an mRNA surveillance mechanism?". Paper presented in European Iron Cub Annual Meeting, St. Gallen, Switzerland., 2008.
  38. Silva, Ana Luísa; Inácio, Ângela; Pereira, Francisco J.C.; Ribeiro, Patricia; Morgado, Ana; Faustino, Paula; Romão, Luísa. "The effect of a small open reading frame on the nonsense-mediated mRNA decay (NMD) mechanism". Paper presented in EMBO 1st Meeting on pre-mRNA Processing and Disease, Cortina D’Ampezzo, Italy., 2007.
  39. Silva, Ana Luísa; Martins, Rute; Ribeiro, Patricia; Faustino, Paula; Lavinha, João; Liebhaber, Stephen A.; Romão, Luísa. "“AUG-proximity effect”: Composition of ribonucleoprotein complexes associated with NMD-resistant beta-globin transcripts". Paper presented in FASEB Summer Research Conferences on Post-transcriptional Control of Gene expression: Mechanisms of mRNA Decay, Snowmass, Colorado,USA., 2006.
  40. Silva, Ana Luísa; Morgado, Ana; Faustino, Paula; Romão, Luísa. "Study of the sequence background effect on the mechanism by which AUG-proximity of nonsense codons inhibits NMD". Paper presented in EMBO workshop on mRNA turnover, EMBO-Workshop, Arolla, Switzerland., 2005.
  41. Pereira, Francisco J.C.; Kong, Jian; Silva, Ana Luísa; Faustino, Paula; Liebhaber, Stephen A.; Romão, Luísa. "The Human alfa- and beta-Globin mRNAs Present Comparable Nonsense-Mediated Decay (NMD) Profiles that Contradict the “-50 Rule”". Paper presented in RNA 2005 - 10th Annual Meeting of the RNA Society , Banff, Canada., 2005.
  42. Inácio, Ângela; Silva, Ana Luísa; Pinto, Joana; Ji, X; Morgado, Ana; Almeida, Fátima; Faustino, Paula; et al. "The strength of the human beta-globin nonsense-mediated mRNA decay depends on a position effect determinant". Paper presented in RNA 2004 - 9th Annual Meeting of the RNA Society , Madison,Wisconsin, USA., 2004.
  43. Silva, Ana Luísa; Inácio, Ângela; Pinto, Joana; Almeida, Fátima; Liebhaber, Stephen A.; Romão, Luísa. "Exon 2 sequences in human ß-globin mRNAs protect mRNAs with 5’- terminal nonsense mutations from accelerated (NMD) decay". Paper presented in RNA 2003, 8th Annual Meeting of the RNA Society, Vienna, Austria., 2003.
  44. Inácio, Ângela; Silva, Ana Luísa; Pinto, Joana; Ji, X; Faustino, Paula; Liebhaber, Stephen A.; Romão, Luísa. "Nonsense-mediated decay of mutant human ß-globin mRNAs appears to depend on a coding region determinant in exon 1.". Paper presented in RNA 2003, 8th Annual Meeting of the RNA Society, Vienna, Austria., 2003.
  45. Inácio, A.; Pinto, J; Almeida, F.; Paula Faustino; Lavinha, J; Romao, L.; Silva, Ana Luísa; et al. "Estudo do mecanismo da estabilidade do RNA mensageiro da beta-globina humana.". Paper presented in 6ª Reunião da Sociedade Portuguesa de Genética Humana. Porto., 2002.
  46. Silva, Ana Luísa; Pinto, Joana; Almeida, Fátima; Inácio, Ângela; Faustino, Paula; Beck, S; Lavinha, João; Romão, Luísa. "Identification of cis-acting determinants involved in the human ß-globin nonsense-mediated mRNA decay". Paper presented in 3th Conference on Hemoglobin Switching, Oxford United Kindom, 2002.
  47. Silva, Ana Luísa; Inácio, Ângela; Pinto, Joana; Almeida, Fátima; Faustino, Paula; Lavinha, João; Romão, Luísa. "Estudo do mecanismo da estabilidade do RNA mensageiro da ß-globina humana". Paper presented in Reunião da Sociedade Portuguesa de Genética Humana, Portugal, Porto., 2002.
  48. Lúcio, P; Santos, An; Santos, In; Faria, Teresa; Silva, MRG; Silva, Ana Luísa; Diamond, Joana; et al. "Detecção de Doença Mínima Residual (DMR) em Carcinoma da Mama por Citometria de Fluxo.". Paper presented in VI Congresso da Sociedade Ibérica de Citometria de Salamanca, Salamanca, Espanha., 1999.
  49. Gameiro, Paula; Vieira, Sara; Bação, Ana; Silva, Ana Luísa; Diamond, Joana; Pereira, F; Quinta Costa; et al. "Monitorização do Transcrito PML/RARA em Leucemia Promielocitica Aguda (LPA)". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Lisboa, Portugal., 1999.
  50. Silva, Ana Luísa; Diamond, Joana; Silva, MRG; Parreira, António; Passos-Coelho, J.L.. "Detecção por RT-PCR de Células Tumorais Residuais de Carcinoma da Mama em produtos Hematopoiéticos: Avaliação da CK20 como marcador molecular". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Lisboa, Portugal., 1999.
Journal article
  1. Ana Luísa Silva; Sayka Barry; Mariana Lopes-Pinto; Rita Joaquim; Catarina Miranda; Fábio Reis; Micaella Miranda; et al. "CCL2 expression predicts clinical outcomes and regulates E-cadherin and angiogenesis in pituitary tumours". Endocrine-Related Cancer (2025): https://doi.org/10.1530/ERC-24-0293.
    10.1530/ERC-24-0293
  2. Lopes-Pinto, Mariana; Lacerda-Nobre, Ema; Silva, Ana Luísa; Marques, Pedro. "Therapeutical Usefulness of PD-1/PD-L1 Inhibitors in Aggressive or Metastatic Pituitary Tumours". Cancers 16 17 (2024): 3033. http://dx.doi.org/10.3390/cancers16173033.
    Published • 10.3390/cancers16173033
  3. Lopes-Pinto, Mariana; Lacerda-Nobre, Ema; Silva, Ana Luísa; Tortosa, Francisco; Marques, Pedro. "The Role of Programmed Cell Death Ligand 1 Expression in Pituitary Tumours: Lessons from the Current Literature". Neuroendocrinology 114 8 (2024): 709-720. http://dx.doi.org/10.1159/000539345.
    10.1159/000539345
  4. Peixe, Carolina; Alexandre, Maria Inês; Gomes, Ana Raquel; Nobre, Ema; Silva, Ana Luísa; Oliveira, Tiago; López-Presa, Dolores; et al. "Usefulness of a clinicopathological classification in predicting treatment-related outcomes and multimodal therapeutic approaches in pituitary adenoma patients: retrospective analysis on a Portuguese cohort of 129 patients from a tertiary pituitary center". Pituitary 26 4 (2023): 352-363. http://dx.doi.org/10.1007/s11102-023-01319-2.
    10.1007/s11102-023-01319-2
  5. Faria, Márcia; Vareda, José; Miranda, Micaella; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells". Cancers 14 21 (2022): 5362. http://dx.doi.org/10.3390/cancers14215362.
    10.3390/cancers14215362
  6. Marques, Pedro; Silva, Ana Luísa; López-Presa, Dolores; Faria, Cláudia; Bugalho, Maria João. "The microenvironment of pituitary adenomas: biological, clinical and therapeutical implications". Pituitary (2022): http://dx.doi.org/10.1007/s11102-022-01211-5.
    10.1007/s11102-022-01211-5
  7. Faria, Márcia; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells". Cancers 13 22 (2021): 5861. http://dx.doi.org/10.3390/cancers13225861.
    10.3390/cancers13225861
  8. Faria, Márcia; Domingues, Rita; Bugalho, Maria João; Matos, Paulo*; Silva, Ana Luísa*. "Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer". Cancers 13 21 (2021): 5460. http://dx.doi.org/10.3390/cancers13215460.
    Open access • Published • 10.3390/cancers13215460
  9. Márcia, Faria; João, Bugalho Maria; Matos, Paulo; Luísa, Silva Ana. "Gß¿-mediated signaling regulates NIS abundance at the plasma membrane". Endocrine Abstracts (2021): http://dx.doi.org/10.1530/endoabs.73.yi11.
    10.1530/endoabs.73.yi11
  10. Faria, Márcia; Domingues, Rita; Paixão, Francisca; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "TNFa-mediated activation of NF-kB downregulates sodium-iodide symporter expression in thyroid cells". PLOS ONE 15 2 (2020): e0228794. http://dx.doi.org/10.1371/journal.pone.0228794.
    Open access • Published • 10.1371/journal.pone.0228794
  11. Faria, Márcia; Félix, Daniela; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Antagonistic effects of RAC1 and tumor-related RAC1b on NIS expression in thyroid". Journal of Molecular Endocrinology 63 4 (2019): 309-320. http://dx.doi.org/10.1530/jme-19-0195.
    10.1530/jme-19-0195
  12. Faria, Márcia; Matos, Paulo; Pereira, Teresa; Cabrera, Rafael; Cardoso, Bruno A.; Bugalho, Maria João; Silva, Ana Luísa. "RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells". PLOS ONE 12 2 (2017): e0172689. http://dx.doi.org/10.1371/journal.pone.0172689.
    10.1371/journal.pone.0172689
  13. Faria, Márcia; Capinha, Liliana; Simões-Pereira, Joana; Bugalho, Maria João; Silva, Ana Luísa. "Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas". International Journal of Endocrinology 2016 (2016): 1-6. http://dx.doi.org/10.1155/2016/1972367.
    10.1155/2016/1972367
  14. Silva, Ana Luísa; Faria, Marcia; Capinha, Liliana; Bugalho, Maria Joao. "RAC1b: A New Player in the Scenario of Thyroid Tumorigenesis?". Advances in Molecular Diagnostics 1 103 (2016): https://www.omicsonline.org/open-access/rac1b-a-new-player-in-the-scenario-of-thyroid-tumorigenesis-AMD-1000103.php?aid=71014&view=mobile.
    Open access • Published
  15. Bugalho, Maria João; Silva, Ana Luísa; Domingues, Rita. "Coexistence of paraganglioma/pheochromocytoma and papillary thyroid carcinoma: a four-case series analysis". Familial Cancer 14 4 (2015): 603-607. http://dx.doi.org/10.1007/s10689-015-9818-8.
    10.1007/s10689-015-9818-8
  16. Pereira, Francisco J.C.; Teixeira, Alexandre; Kong, Jian; Barbosa, Cristina; Silva, Ana Luísa; Marques-Ramos, Ana; Liebhaber, Stephen A.; Romão, Luísa. "Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity". Nucleic Acids Research 43 13 (2015): 6528-6544. http://dx.doi.org/10.1093/nar/gkv588.
    10.1093/nar/gkv588
  17. Silva, A. L.; Carmo, F.; Moura, M. M.; Domingues, R.; Espadinha, C.; Leite, V.; Cavaco, B.; Bugalho, M. J.. "Identification and characterization of two novel germline RET variants associated with medullary thyroid carcinoma". Endocrine 49 2 (2015): 366-372. http://dx.doi.org/10.1007/s12020-015-0559-0.
    10.1007/s12020-015-0559-0
  18. Onofre, Cláudia; Tomé, Filipa; Barbosa, Cristina; Silva, Ana Luísa; Romão, Luísa. "Expression of Human Hemojuvelin (HJV) Is Tightly Regulated by Two Upstream Open Reading Frames in HJV mRNA That Respond to Iron Overload in Hepatic Cells". Molecular and Cellular Biology 35 8 (2015): 1376-1389. http://dx.doi.org/10.1128/mcb.01462-14.
    10.1128/mcb.01462-14
  19. Silva, A.L.; Carmo, F.; Bugalho, M.J.; Silva, Ana Luísa; Carmo, Francisca; Bugalho, Maria João. "RAC1b overexpression in papillary thyroid carcinoma: A role to unravel". European Journal of Endocrinology 168 6 (2013): 795-804. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878720708&partnerID=MN8TOARS.
    10.1530/EJE-12-0960
  20. Morgado, Ana; Almeida, Fátima; Teixeira, Alexandre; Silva, Ana Luísa; Romão, Luísa. "Unspliced Precursors of NMD-Sensitive ß-Globin Transcripts Exhibit Decreased Steady-State Levels in Erythroid Cells". PLoS ONE 7 6 (2012): e38505. http://dx.doi.org/10.1371/journal.pone.0038505.
    10.1371/journal.pone.0038505
  21. Martins, Rute; Proença, Daniela; Silva, Bruno; Barbosa, Cristina; Silva, Ana Luísa; Faustino, Paula; Romão, Luísa. "Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels". PLoS ONE 7 4 (2012): e35461. http://dx.doi.org/10.1371/journal.pone.0035461.
    10.1371/journal.pone.0035461
  22. Espadinha, Carla; Silva, Ana Luísa; Cabrera, Rafael; Bugalho, Maria João. "Molecular Analysis of TTF-1 and TTF-2 Genes in Patients with Early Onset Papillary Thyroid Carcinoma". Journal of Oncology 2012 (2012): 1-6. http://dx.doi.org/10.1155/2012/359246.
    10.1155/2012/359246
  23. Peixeiro, I.; Inácio, A.; Barbosa, C.; Silva, A.L.; Liebhaber, S.A.; Romão, L.. "Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations". Nucleic Acids Research 40 3 (2012): 1160-1173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856875524&partnerID=MN8TOARS.
    10.1093/nar/gkr820
  24. Peixeiro, I.; Silva, A. L.; Romao, L.. "Control of human  -globin mRNA stability and its impact on beta-thalassemia phenotype". Haematologica 96 6 (2011): 905-913. http://dx.doi.org/10.3324/haematol.2010.039206.
    10.3324/haematol.2010.039206
  25. Silva, Ana Luísa; Romão, Luísa. "The mammalian nonsense-mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?". FEBS Letters 583 3 (2009): 499-505. http://dx.doi.org/10.1016/j.febslet.2008.12.058.
    10.1016/j.febslet.2008.12.058
  26. Silva, A. L.; Ribeiro, P.; Inacio, A.; Liebhaber, S. A.; Romao, L.. "Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay". RNA 14 3 (2008): 563-576. http://dx.doi.org/10.1261/rna.815108.
    10.1261/rna.815108
  27. Inácio, Ângela; Silva, Ana Luísa; Morgado, Ana; Pereira, Francisco J C; Lavinha, João; Romão, Luísa. "Comment on ‘Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease’". European Journal of Human Genetics 15 5 (2007): 533-534. http://dx.doi.org/10.1038/sj.ejhg.5201808.
    10.1038/sj.ejhg.5201808
  28. Silva, A. L.; Pereira, F. J.C.; Morgado, A.; Kong, J.; Martins, R.; Faustino, P.; Liebhaber, S. A.; Romao, L.. "The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context". RNA 12 12 (2006): 2160-2170. http://dx.doi.org/10.1261/rna.201406.
    10.1261/rna.201406
  29. Inácio, Ângela; Silva, Ana Luísa; Romão, Luísa. "Mechanisms of the human beta-globin mRNA stability". Journal of Biological Sciences 5 1 (2005): 21-32. http://docsdrive.com/pdfs/ansinet/jbs/2005/21-32.pdf.
    Published • 10.1093/nar/26.3.721
  30. Inacio, Angela; Silva, Ana Luisa; Romão, Luísa. "Mechanisms of the Human ß-globin mRNA Stability". Journal of Biological Sciences 5 1 (2005): 21-32. http://dx.doi.org/10.3923/jbs.2005.21.32.
  31. Inácio, Ângela; Silva, Ana Luísa; Pinto, Joana; Ji, Xinjun; Morgado, Ana; Almeida, Fátima; Faustino, Paula; et al. "Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay". Journal of Biological Chemistry 279 31 (2004): 32170-32180. http://dx.doi.org/10.1074/jbc.m405024200.
    10.1074/jbc.m405024200
  32. Silva, A. L.. "Human mammaglobin RT-PCR assay for detection of occult breast cancer cells in hematopoietic products". Annals of Oncology 13 3 (2002): 422-429. http://dx.doi.org/10.1093/annonc/mdf107.
    10.1093/annonc/mdf107
  33. Silva, A.L.; Diamond, J.; Silva, M.R.G.; Passos-Coelho, J.L.. "Cytokeratin 20 is not a reliable molecular marker for occult breast cancer cell detection in hematological tissues". Breast Cancer Research and Treatment 66 1 (2001): 59-66. http://dx.doi.org/10.1023/a:1010628802290.
    10.1023/a:1010628802290
  34. Gameiro, P.; Vieira, S.; Carrara, P.; Silva, A.L.; Diamond, J.; De Sousa, A.B.; Mehta, A.B.; et al. "The PML-RARa transcript in long-term follow-up of acute promyelocytic leukemia patients". Haematologica 86 6 (2001): 577-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034962192&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Silva, Ana Luísa. "Mammalian nonsense mediated mRNA decay: new determinants that make transcripts bearing a small open reading frame resistant to rapid decay". PhD, Universidade de Lisboa Faculdade de Ciências, 2008.
  2. Silva, Ana Luísa. "O RT-PCR na Detecção de Marcadores Moleculares de Leucemia Aguda: Diagnóstico e Avaliação de Doença Mínima Residual". Degree, Universidade de Lisboa Faculdade de Ciências, 1998.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/19 From Mechanisms to Medicine: The Role of NIS in Hard-to-Treat Thyroid Cancers. Católica Medical Seminars
Católica Medical School (Rio de Mouro, Portugal)
2023/11 E-cadherin downregulation may contribute to increased proliferation, aggressiveness and refractoriness in pituitary neuroendocrine tumors. ENEA Workshop 7-9 December 2023, Munique, Germany.
European Neuroendocrine Association (Munique, Germany)
2023/09/10 SRC/RAC1 Pathway and other NIS Plasma Membrane Interactors in NIS regulation. Scientific Symposium - Thyroid Cancer Basic: New molecules for better treatments. 45th Annual Meeting of the European Thyroid Association,
European Thyroid Association (Milão)
2023/02/06 Classificação clínico-patologica de Trouillas prediz refractoriedade e abordagem terapêutica complexa em doentes com adenomas hipofisários. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo,Vilamoura, Portugal.
(Vilamoura, Portugal)
2023/02/06 The role of CCL2 and IL-8 in the microenvironment of pituitary neuroendocrine tumors. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo,Vilamoura, Portugal.
2023/02/06 E-Cadherin downregulation is associated with more proliferative and refractory pituitary tumors. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, Vilamoura, Portugal.
2023/02/06 High PD-L1 expression predicts need for multiple treatment in Pituitary Neuroendocrine Tumors. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, Vilamoura, Portugal.
2022/02/03 Papel das lamininas na regulação da abundância de NIS na membrana plasmática. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade de Endocrinologia Diabetes e Metabolismo (Vilamoura, Portugal)
2021/05/26 Gß¿-mediated signaling regulates NIS abundance at the plasma membrane. 23rd European Congress of Endocrinology
European Society of Endocrinology (Virtual)
2020/01/25 A expressão de NIS é regulada pelo NF-kB em resposta ao TNF-a em tecido tiroideu. Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo, 23-26 Janeiro, Coimbra, Portugal.
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo (Coimbra, Portugal)
2018/06/22 Molecular Markers in Gastroenteropancreatic Neuroendocrine Neoplasms 6thNetwork on neuroendocrine tumors
SPEDM (Lisboa, Portugal)
2018/06/02 Thyroid Tumorigenesis: Tales of RAC1b, Pharmacology Series
Faculdade de Medicina da Universidade de Lisboa (lisboa, Portugal)
2017/09 Unravelling the Signaling Pathways Influencing the NIS regulation. EYES (European Young Endocrine Scientists) Meeting
(Porto, Portugal)
2016/10/19 Tumor-associated RAC1b overexpression: A New Player in the Scenario of Thyroid Tumorigenesis? BioISI Research Seminar
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2015/01/23 Análise da expressão de RAC1b em tumores foliculares da tiroide XVI Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade de Endocrinologia Diabetes e Metabolismo (Funchal, Portugal)
2014/01/24 Avaliação do potencial oncogénico de duas novas variantes germinais do gene RET associadas a Carcinoma Medular da Tiroide. XV Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade de Endocrinologia Diabetes e Metabolismo (Vilamoura, Portugal)
2013/12/06 Rac1b expression in Papillary Thyroid Carcinoma: association with BRAF V600E mutation and patient’s outcome 7th National Meeting on Cell Signalling – SINAL2013
(Aveiro, Portugal)
2010/11/18 Post-transcriptional control of hemojuvelin gene expression and its relevance on iron homeostasis. XIV Jornadas da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Coimbra, Portugal)
2009 Mammalian nonsense-mediated mRNA decay: a role for PABPC1 in the NMD-resistance of transcripts bearing AUG-proximal premature termination codons. , Carcavelos, Portugal. Vth National Meeting on RNA Biology
(Carcavelos, Portugal)
2009 Does nonsense-mediated messenger RNA decay play a role in post-transcriptional regulation of HFE? Vth National Meeting on RNA Biology
(Carcavelos, Portugal)
2007 A role for PABPC1 on nonsense-mediated decay inhibition of mammalian mRNAs carrying a short open reading frame EMBO Conference on Protein Synthesis and Translational Control
EMBO (Heidelberg, Germany)
2007 The proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated decay. IVth National Meeting on RNA Biology
(Vimeiro, Portugal)
2006 AUG-proximity effect”: what makes mRNAs bearing a small ORF escape NMD? IIIrd National Meeting on RNA Biology,
(Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09 - Current Enhancing Iodide Uptake in Refractory Thyroid Cancer: Investigating Modulators of Cell Matrix Adhesion Signaling Affecting NIS Abundance and Retention at the Plasma Membrane.
Supervisor
 Bioquímica (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/09 - Current Pituitary neuroendocrine tumour microenvironment: A role for CCL2 and IL-8.
Supervisor
 Mestrado em Biologia Molecular e Genética, (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2016/01/02 - Current Targeting RAC1- signaling to enhance iodide - related cancer therapy
Co-supervisor
 Biologia (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09 - 2024 Impact of cell-matrix adhesion dynamics in NIS residency at the plasma membrane.
Supervisor
 Mestrado em Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09 - 2023 Epithelial mesenchymal transition pathway in pituitary endocrine tumours.
Supervisor
 Mestrado em Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2023 Evaluation of the effect of specific molecular targets on plasma membrane abundance and retention of the sodium and iodine symporter (NIS).
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/09/15 - 2023 Search for novel modulators of NIS abundance and retention at the plasma membrane to enhance iodide uptake in refractory thyroid cancer.
Supervisor of José António Vareda
 Mestrado em Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2021/03 Development of cellular models for sodium iodide symporter (NIS) functional expression
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10 - 2019/05 Deciphering the pathways leading to the enhancement of NIS gene expression in thyroid tissue.
Supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Crosstalk between NF-kB and PI3K-Akt-mTOR signalling in thyroid cancer: the pursuit of novel therapeutic options
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017 As GTPases RAC1 e RAC1b na modulação da expressão do simportador de sódio e iodo em tecido tiroideu normal
Supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Overexpression of RAC1b in follicular cell derived thyroid cancers: An activator of NF-¿B pathway that contributes to thyroid tumorigenesis?
Supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Interplay between RAC1b and Sodium Iodide symporter in thyroid and breast cancers.
Supervisor
 Mestrado em Genética Molecular e Biomedicina
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 In vitro assessment of the oncogenic potential of novel MTC-associated germline RET mutations
Supervisor
 Biologia Evolutiva e do Desenvolvimento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Controlo pós-transcricional da expressão da hemojuvelina e o seu papel na homeostase do ferro
Co-supervisor
 Mestrado em Biologia Molecular Humana (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2006 Estudo do mecanismo de inibição do decaimento do mRNA da ¿-globina humana mediado por mutações nonsense: efeito da poly(A)-binding protein. Licenciatura em Biologia. Universidade de Évora (Co-orientadora).
Co-supervisor
 Biologia (Degree)
Universidade de Évora, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/04 - 2019/02/08 Curso Prático de Endocrinologia Molecular - bench-to-bedside workshop dirigido a internos de endocrinologia (2019/02/04 - 2019/02/08)
Workshop (Member of the Organising Committee)
 Hospital de Santa Maria, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2015/05/23 - 2015/05/23 iNOVA4Health Research Unit (IBET, ITQB-UNL, CEDOC|NMS, IPOLFG) kickoff meeting (2015/05/23 - 2015/05/23)
Meeting (Member of the Organising Committee)
 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2013 - 2015 Ciclos de Seminários da UIPM - Unidade de Investigação em Patobiologia Molecular (2013)
Seminar (Co-organisor)
 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019 - 2019 Molecular Oncology: from the bench to the bedside. Advanced Courses in Molecular Medicine
Workshop
 Molecular Oncology: from the bench to the bedside
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2007 IX Symposium on Mechanisms of Gene Expression
Symposium
 IX Symposium on Mechanisms of Gene Expression
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005/09 - 2005/09 EMBO workshop on mRNA turnover
Workshop
 EMBO-Workshop, Arolla, Switzerland.

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Biomarcadores Moleculares para Diagnóstico de Doença Nodular da Tiroide
(Thesis) Main arguer
 Maria de Lurdes Méha Godinho de Matos, (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023 Characterization of TYK2 role in IL-7/IL-7R signaling in T-cell Acute Lymphoblastic Leukemia,
(Thesis) Main arguer
 Joana Margarida Bartolomeu Cavaco, (Master)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023 Human Papilloma Viruses in head and neck squamous cell carcinomas: the relevance of HPV16 variants,.
(Thesis) Arguer
 Daniela Cochicho Tavares de Sousa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 BRD9 as a Novel Susceptibility Gene for Familial Cutaneous Melanoma.
(Thesis) Main arguer
 Renato Xavier Arnêdo Ferreira (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 Evaluating the impact of 2D, 3D static and 3D microfluidic tissue culture conditions on the in vitro response of cancer cells to chemotherapeutic agents
(Thesis) Main arguer
 Mariana Gaspar de Almeida (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 Investigating the role of p53 mRNA elements on the translation of different oncogenic proteins.
(Thesis) Main arguer
 Inês Maria Fogaça da Fonseca Costa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 Study of human Argonaute 1 cap-independent translation
(Thesis) Main arguer
 Manuel Nuno Condinho Rodrigues Reis de Carvalho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 Molecular characterization of novel candidate genes involved in the initiation of multiple primary melanomas
(Thesis) Main arguer
 Catarina Paula Abreu Campos (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 Analysis of translation of 5’ untranslated regions in cancer
(Thesis) Arguer
 Joana Filipa Pires Silva (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 The role of NRARP in the regulation of Wnt signaling pathway in T-cell acute lymphoblastic leukemia
(Thesis) Main arguer
 Joana Margarida Luís Gonçalves (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 Identificação de potenciais variantes patogénicas em famílias com história familiar de melanoma.
(Thesis) Main arguer
 Margarida dos Reis Pereira Pataco (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 Establishment of a suppression therapy for beta-thalassemia due to a nonsense mutation
(Thesis) Main arguer
 Patrícia Sofia Martins Dias (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 Role of EGF mediated laminin y2 chain in uterine cervix carcinoma
(Thesis) Main arguer
 Cristiano Manuel Colaço Ramos (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 The pathogenic role of mTOR pathway in papillary thyroid carcinoma and its impact on sodium iodide symporter (NIS) expression
(Thesis) Main arguer
 Ana Catarina Marques Gomes (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2016 The effect of G418 and PTC124 as suppression therapy for Beta Thalassemia
(Thesis) Main arguer
 Cláudia Filipa de Noronha Estima (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 The mechanism of nonsense-mediated mRNA decay
(Thesis) Main arguer
 Nuno Filipe Teixeira Costa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases
(Thesis) Main arguer
 Francesca Manuela Johnson de Sousa Brito (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Identificação de biomarcadores de prognóstico e marcadores preditivos de resposta à terapia no Cancro do Cólon e Recto
(Thesis) Main arguer
 Marisa Sofia Marçalo Paulino (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 Translational Control by An Upstream Open Reading Frame in the Human Erythropoietin Transcript
Thesis Member
 Cristina Maria Botelho da Rocha Barbosa (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 The role of Rac1-modulated gene transcription in tumorigenesis
Thesis Member
 Patrícia Alexandra de Sousa Barros (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 Analysis of the intracnuclear life of nonsense transcripts
Thesis Member
 Ana Sofia João Morgado (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Gene expression regulation of hemojuvelin by two small open reading frames
(Thesis) Main arguer
 Cláudia Onofre (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/02/01 - 2022/02/01 Cancers
2021/06/10 - 2021/06/10 Bioengineered
2021/03/05 - 2021/03/05 FASEB Jornal
2021/02/02 - 2021/02/02 Cancers
2021 - 2021 Theranostics
2020/09/24 - 2020/09/24 Cancers
2018 - 2018 Journal of Cellular Biochemistry (1097-4644) Wiley (John Wiley & Sons)
2018 - 2018 Cell Communication and Signaling (1478-811X) Springer (Biomed Central Ltd.)
2017 - 2017 Scientific Reports (2045-2322) Springer Science and Business Media LLC
2016 - 2016 PLoS ONE (1932-6203) Public Library of Science
2015 - 2015 World Journal of Surgical Oncology (1477-7819) Springer (Biomed Central Ltd.)
2015 - 2015 Revista Portuguesa de Endocrinologia Diabetes e Metabolismo (1646-3439) Elsevier
2014 - 2014 Medical Oncology (1559-131X) Springer-Verlag
2014 - 2014 Critical Reviews in Clinical Laboratory Sciences (1549-781X) Informa UK (Taylor & Francis)

Association member

Society Organization name Role
2022/11/10 - Current Ordem dos Biólogos Membro Efetivo nº 4584
2011 - Current Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo Sócio

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Módulo de Genética - Genética do Metabolismo do Iodo Mestrado em Doenças Metabólicas e do Comportamento Alimentar (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2015 Endocrinologia Molecular Especialidades Médicas e Cirúrgicas II (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2014 Ensaios funcionais in vitro para avaliação do potencial oncogénico de novas mutações. Programa Doutoral NOVA medical School (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006 - 2008 Genética Nutrição Humana, Social e Escolar (Licenciatura) Escola Superior de Educação Jean Piaget de Almada, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019 - Current Member of the thesis advisory committee (BioSys PhD Program)- Juan Fernández García-Moreno - The involvement of DIS3L2 in nonsense-mediated mRNA decay and its functional networks in cancer. The thesis advisory committee is responsible for monitoring the progress and development of the PhD Student and to provide advice and support to both student and supervisor.
Specialist
 Universidade de Lisboa Faculdade de Ciências, Portugal Fundação para a Ciência e a Tecnologia
2015 - 2018 Member of the thesis advisory committee (BioSys PhD Program) Joana Filipa Pires Silva - Analysis of translation of 5' untranslated regions in cancer
Specialist
 Universidade de Lisboa Faculdade de Ciências, Portugal Fundação para a Ciência e a Tecnologia
2015 - 2018 Member of the thesis advisory committee (BioSys PhD Program) - Andreia Filipa Almeida Henriques - Regulation of glucose uptake in mammalian cells by protein phosphorylation networks
Specialist
 Universidade de Lisboa Faculdade de Ciências, Portugal Fundação para a Ciência e a Tecnologia
2014 - 2017 Member of the thesis advisory committee (BioSys PhD Program) - Claúdia Almeida Loureiro - Regulation of epithelial chloride transport by phospho-tyrosineinitiated protein networks
Specialist
 Universidade de Lisboa Faculdade de Ciências, Portugal Fundação para a Ciência e a Tecnologia

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/11 Ana Luísa Silva: Investigadora, professora, coordenadora e Aluna Divide-se em múltiplas tarefas e a ciência é, sem dúvida, a área que abraçou como forma de vida, investigadora a tempo inteiro, decidiu este ano voltar a ser aluna. Inscreveu-se no MIM na FMUL e divide o tempo entre ser professora, aluna, mulher e mãe. Vamos saber como é que as peças deste puzzle se encaixam umas nas outras. news@fmul

Mentoring / Tutoring

Topic Student name
2022/06/01 - 2022/08/31 Expressão de PD-L1 em tumores neuroendócrinos hipofisários e sua correlação com características clinico-patológicas e outcomes clínicos. Mariana Lopes Pinto
2021/07/01 - 2021/09/30 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- Inês Cosme
2020/10/01 - 2020/12/31 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- Maria Inês Afonso
2020/08/01 - 2020/09/30 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- João Roque
2020/06/01 - 2020/07/31 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- Alexandra Araujo
2019/10/01 - 2019/11/30 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- Cristiana Gomes da Costa
2019/07/01 - 2019/07/31 Research Exchanges Program SCORE 2019 Aleksandra Marczak
2019/07/01 - 2019/07/31 Research Exchanges Program SCORE 2019 Yu-Ju Yeh
2019/02/01 - 2019/03/31 Estágios de Internato Médico no âmbito do Internato Complementar de Endocrinologia e Nutrição do Hospital de Santa Maria do Centro Hospitalar Universitário de Lisboa Norte- David Oliveira Barbosa
2018/07/01 - 2018/07/31 Research Exchanges Program SCORE 2018 Alexander Esposito
2018/07/01 - 2018/07/31 Research Exchanges Program SCORE 2018 Anton Safonov
2017/07/01 - 2017/07/31 Research Exchanges Program SCORE 2017 Eszter Muller
2017/07/01 - 2017/07/31 Research Exchanges Program SCORE 2017 Nevena Popovac

Scientific expedition

Activity description Institution / Organization
2016 - Current Group Leader, Molecular Biology Research Unit, Department of Endocrinology Diabetes and Metabolism, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, E.P.E. ; Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2020/04 - 2020/06 COVID-19 IMM Task Force:Voluntária na equipa de análise de resultados. Esta Task Force envolveu cerca de 100 voluntários no rastreio da presença de SARS-CoV-2, por PCR em tempo real, a partir de esfregaços nasofaríngeos ou orofaríngeos, através de um protocolo baseado no teste desenvolvido pelo CDC “Center for Disease Control and Prevention (CDC), seguindo todas as orientações referentes ao manuseamento e análise de espécimes clínicos. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Distinctions

Award

2025 Menção Honrosa - Prémio de Investigação Básica, Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2024 Prémio Investigação Básica da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2023 1st prize Basic Research, Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2021 Prémio Prof. E. Limbert SPEDM/Merck em Patologia da Tiroide
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo , Portugal
2021 ESE Young Investigator Awards for 2021- ¿Gß¿-mediated signaling regulates NIS abundance at the plasma membrane.
European Society of Endocrinology, United Kingdom
2020 Honorable mention in Basic Research, Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo , Portugal
2016 Prémio Prof. E. Limbert SPEDM/Genzyme em Patologia da Tiroide
2015 1st prize Basic Research, Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo , Portugal
2014 1st prize Basic Research, Congresso Português da Sociedade de Endocrinologia Diabetes e Metabolismo
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo , Portugal
2012 Prémio Prof. E. Limbert SPEDM/Genzyme em Patologia da Tiróide
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo , Portugal
2002 First prize Labmed 2001 awards
1993 Academic award for the three best classifications within the first year science school students
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal