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Identification

Personal identification

Full name
Dany Silva

Citation names

  • Silva, Dany
  • Silva, D.

Author identifiers

Ciência ID
D11F-F409-05A4
ORCID iD
0000-0002-6800-9621

Email addresses

  • up201708266@fc.up.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2020/12/31 - 2024/12/31
Ongoing
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Contribution of adrenergic signaling to breast tumorigenesis and its modulation by hormone replacement therapy" (THESIS/DISSERTATION)
2019/10/01
Concluded
 Biologia Molecular e Celular (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Adrenergic contribution to the stress induced carcinogenesis" (THESIS/DISSERTATION)
 18
2017/06/01
Concluded
 Biologia (Licenciatura)
Universidade de Aveiro, Portugal
"Role of ADO-AR system in the complex interaction of Leishmania-macrophages " (THESIS/DISSERTATION)
 16
Affiliation

Others

Category
Host institution 		Employer
2019/12/04 - 2020/06/01 Research fellow Universidade do Porto Faculdade de Farmácia, Portugal
2017/09 - 2018/04 Operational Assistant Universidade do Porto Faculdade de Farmácia, Portugal
Outputs

Publications

Conference poster
  1. Silva, Dany; Quintas, Clara; Gonçalves, Jorge; Fresco, Paula. "ß-Adrenergic stimulation may promote a pre-malignant phenotype in non-tumorigenic MCF-10A breast epithelial cells". Paper presented in 13th EMBO Young Scientists’ Forum, 2023.
  2. Silva, Dany; Amaro, F.; Reguengo, H.; Oliveira, J.C.; Quintas, C.; Vale, N.; Gonçalves, J.; Fresco, P.. Corresponding author: Gonçalves, J.. "Catecholamines produced by breast epithelial cells exert tonic effects relevant for breast cancer progression". Paper presented in 27th Porto Cancer Meeting 2021, 2021.
  3. Duarte, D.; Amaro, F.; Silva, I.; Silva, D.; Fresco, P.; Oliveira, J.C.; Reguengo, H.; Gonçalves, J.; Vale, N.. "Carbidopa alters tryptophan metabolism in breast and melanoma cancer cells". Paper presented in 1º Encontro Anual de Ciências Farmacêuticas, Coimbra, 2019.
  4. Silva, Dany; Moreira, D.; Cordeiro-da-Silva, A.; Gonçalves, J.; Fresco, P.. "Intracellular adenosine released from Leishmania infantum infected macrophages is involved in an autocrine control of macrophage immune response". Paper presented in Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto,, 2019.
  5. Correia, A.; Silva, D. (D11F-F409-05A4); Gartner, F.; Vale, N.. "Study of new therapeutic strategies to combat mammary cancer". Paper presented in Encontro de Investigação Jovem da Universidade do Porto (IJUP), 2018, 2018.
  6. Amaro, F.; Silva, D. (D11F-F409-05A4); Dimco, G.; Gonçalves, J.; Vale, N.; Fresco, P.. "The role of adrenergic receptors in carcinogenesis". Paper presented in Encontro de Investigação Jovem da Universidade do Porto (IJUP), 2018, 2018.
  7. Correia, Ana; Silva, Dany; Gärtner, Fátima; Vale, Nuno. "Study of New Therapeutic Strategies to Combat Breast Cancer". Paper presented in IJUP 2018 ¿ 11º Encontro de Jovens Investigadores da Universidade do Porto, 2018.
Journal article
  1. Victória Piazzalunga; Dany Silva; Allal Badr-Eddine; Patrícia Nogueira; J.Gonçalves; Paula Fresco. "Challenges in Pharmacological Intervention in Perilipins (PLINs) to Modulate Lipid Droplet Dynamics in Obesity and Cancer". Cancers (2023): https://www.mdpi.com/2072-6694/15/15/4013.
    10.3390/cancers15154013
  2. Allal, Bader-Edine; Bounaama, Abdelkader; Silva, Dany; Quintas, Clara; Dahlouk, Salim Ismail; Gonçalves, Jorge; Djerdjouri, Bahia. "Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming". Naunyn-Schmiedeberg's Archives of Pharmacology (2023): http://dx.doi.org/10.1007/s00210-023-02403-x.
    10.1007/s00210-023-02403-x
  3. Dany Silva; Katarzyna Kacprzak; Clara Quintas; J.Gonçalves; Paula Fresco. "Activation of ß-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/1/767.
    10.3390/ijms24010767
  4. "Contribution of adrenergic mechanisms for the stress-induced breast cancer carcinogenesis". Journal of Cellular Physiology (2022): http://dx.doi.org/10.1002/jcp.30707.
    10.1002/jcp.30707
  5. "Effects of single and combined exposures of gold (nano versus ionic form) and gemfibrozil in a liver organ culture of Sparus aurata". Marine Pollution Bulletin (2020): http://dx.doi.org/10.1016/j.marpolbul.2020.111665.
    10.1016/j.marpolbul.2020.111665
  6. "ß-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells.". International journal of molecular sciences (2020): https://europepmc.org/articles/PMC7672553.
    10.3390/ijms21217968
  7. "Intracellular adenosine released from THP-1 differentiated human macrophages is involved in an autocrine control of Leishmania parasitic burden, mediated by adenosine A2A and A2B receptors". European Journal of Pharmacology (2020): http://dx.doi.org/10.1016/j.ejphar.2020.173504.
    10.1016/j.ejphar.2020.173504
  8. Gonçalves, J.; Quintas, C.; Silva, Dany; Queiroz, G.; Fresco, P.. "Efeitos Terapêuticos Improváveis de Fármacos Comuns: Lições de 15 Anos de Drug Repurposing". Revista Portuguesa de Farmacoterapia 11 4 (2020): 8-16. http://revista.farmacoterapia.pt/index.php/rpf/article/view/265.
    10.25756/rpf.v11i4.228
  9. Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, Paula. "Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug Repurposing". (2020): https://doi.org/10.25756/rpf.v11i4.228.
    https://doi.org/10.25756/rpf.v11i4.228
  10. Chda, A.; El Kabbaoui, M.; Fresco, P.; Silva, D.; Gonçalves, J.; Oliveira, A.P.; Andrade, P.B.; et al. "Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways.". Planta medica (2019): http://europepmc.org/abstract/med/31645066.
    10.1055/a-1023-8918
  11. Duarte, D.; Amaro, F.; Silva, I.; Silva, D.; Fresco, P.; Oliveira, J.C.; Reguengo, H.; Gonçalves, J.; Vale, N.. "Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite.". Biomolecules (2019): http://europepmc.org/abstract/med/31450593.
    10.3390/biom9090409
  12. Correia, A.; Silva, D.; Vilanova, M.; Gartner, F.; Vale, N.. "Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations.". Biomolecules (2018): http://europepmc.org/abstract/med/30558247.
    10.3390/biom8040175
Magazine article
  1. Silva, Dany; Quintas, Clara; Goncalves, Jorge; Fresco, Paula. "ß2-Adrenoceptor Activation Favor Acquisition of Tumorigenic Properties in Non-Tumorigenic MCF-10A Breast Epithelial Cells", Cells, 2024, https://doi.org/10.3390/cells13030262.
    10.3390/cells13030262
Thesis / Dissertation
  1. Silva, Dany. "Adrenergic contribution to the stress induced carcinogenesis". Master, Universidade do Porto Faculdade de Ciências, 2019.
  2. Silva, Dany. "Role of ADO-AR system in the complex interaction of Leishmania-macrophages". Degree, Universidade de Aveiro, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/02 Influence of adrenergic agonists on the induction of cancer hallmarks in non-tumorigenic MCF-10A cells SPF - 2022, LII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2021/02 Tonic activation of ß- and a2-adrenoceptors by catecholamines release from breast cancer cells may contribute to cancer progression SPF - 2021, LI Reunião Anual da Sociedade Portuguesa de Farmacologia
2019/02 Intracellular adenosine released from Leishmania infected macrophages is involved in an autocrine control of macrophage response, through A2 adenosine receptors activation SPF - 2019, XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2019/02 Study of new therapeutic strategies to combat breast cancer SPF 2019 - XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2019/02 Neoplastic transformation of breast epithelial cells induced by catecholamines SPF 2019 - XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2017/02 Endogenous adenosine favours macrophage infection by Leishmania by activating adenosine A2 receptors SPF 2017 - XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/04 - 2019/02/06 SPF - 2019, XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia (2019/02/04 - 2019/02/06)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/02/05 - 2020/02/07 Lectures in various fields of health sciences
Conference
 50.ª Reunião da Sociedade Portuguesa de Farmacologia
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/10/15 - 2019/10/16 Lecture about safety, innovation and quality in laboratories
Seminar
 Seminário labtalks – Segurança, Inovação e Qualidade em Laboratórios
Universidade do Porto Porto Business School, Portugal

MODUS COMPLETE, Portugal
2019/05/08 - 2019/05/08 Lecture about cell culture
Congress
 VWR Day, Maio 2019
VWR International, United Kingdom
2019/02/06 - 2019/02/08 Lectures in various fields of health sciences
Conference
 XLIX Reunião da Sociedade Portuguesa de Farmacologia
Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/06 - 2018/07/06 Lecture on cell imaging techniques
Seminar
 Cellular Imaging Seminar and Workshop of Biotek - Take Your Research to the Next Dimension
Universidade do Porto Faculdade de Farmácia, Portugal
2018/01/08 - 2018/01/12 Lecture in the field of oncology
Congress
 International Intensive Course on Cancer Biology
Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/25 - 2017/09/29 Lecture entitled "Approaches for developing anti-Leishmania vaccines"
Congress
 MuLeVaClin Summer School 2017
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/02/02 - 2017/02/04 Lectures in various fields of health sciences
Conference
 XLVII Reunião da Sociedade Portuguesa de Farmacologia
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/05 - 2016/05 Lectures on toxicology and ecotoxicology
Conference
 TOXECO 2016
Universidade de Aveiro, Portugal
2015/12/05 - 2015/12/05 Lecture in the field of clinical oncology
Conference
 VII Workshop de Prática de Farmácia do IUCS
Instituto Universitário de Ciências da Saúde, Portugal