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Identification

Personal identification

Full name
Paulo Jorge Pereira Alves Paixão

Author identifiers

Ciência ID
D11F-56FF-318E
ORCID iD
0000-0001-6554-4840

Email addresses

  • ppaixao@ff.ul.pt (Professional)

Addresses

  • Universidade de Lisboa, Faculdade de Farmácia, Unidade de Farmacologia e Farmacotoxicologia. Av. das Forças Armadas, 1649-083, Lisboa, Lisboa, Portugal (Professional)

Websites

Education
Degree Classification
2006 - 2010
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Biofarmácia e Farmacocinética
Universidade de Lisboa, Portugal
"In Silico Prediction of Human Oral Bioavailability" (THESIS/DISSERTATION)
 Distinção e Louvor
1999 - 2002
Concluded
 Biofarmácia e Farmacocinética Avançada (Mestrado)
Universidade de Lisboa, Portugal
"Toxicocinética do Paraquato em pacientes Humanos" (THESIS/DISSERTATION)
 Muito Bom
1992 - 1997
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa, Portugal
"Estudo do metabolismo da Primaquina" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2016/06 - 2016/09 Auxiliary Researcher (Research) University of Michigan, United States
1999/10 - 2001/08 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
1997/09 - 1999/09 Research Trainee (Research) Laboratório Nacional de Energia e Geologia, Portugal
1996/10 - 1997/07 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/12/02 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/09 - 2019/12/01 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/01 - 2018/06 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - 2010/12 Invited Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/01/01 - Current Member of the Methodological Working Party European Medicines Agency, United Kingdom
2020/03 - Current Expert on the M13 informal WG Bioequivalence for Immediate-Release Solid Oral Dosage Forms ICH - International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use, Switzerland
2013/09 - Current Member of the Medicines Evaluation Board (Comissão de Avaliação de Medicamentos) Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2019/09 - 2023/01/31 Member of the Pharmacokinetics Working Party European Medicines Agency, United Kingdom
2018/07/15 - 2019/07/15 National Expert on Secondment European Medicies Agency, United Kingdom

Others

Category
Host institution 		Employer
2011/01 - 2012/09 Pós-doutoramento (Investigação Científica) Fundação para a Ciência e a Tecnologia, Portugal
2003/10 - 2010/10 Consultor (Avaliador Técnico) Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2006/10 - 2010/07 Doutorando (Investigação Científica) Fundação para a Ciência e a Tecnologia, Portugal
Projects

Grant

Designation Funders
2013/06 - 2015/10 Pharmacokinetic/Pharmacogenetic modulation of HIV infection therapy by bayesian and artificial intelligence methods
Provided by PTCRIS: 127055
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2014 - Current Individualized Therapeutic Drug monitoring of Busulfan in hematopoietic Stem-cells pre-transplant conditioning at IPO Lisbon
UIC/963
Supervisor
N/A
2018 - 2020 NPSTEENBRAIN ¿ New Psychoactive Substances. A platform for risk assessment of Teens Brain Exposure
32515
Researcher
Ongoing
2016 - 2019 Innovations in Regulatory Science: in vivo Predictive Dissolution to Advance Oral Product Bioequivalence (BE) Regulation
FDABAA-15-0121
Researcher
Concluded

Other

Designation Funders
2017 - 2021 UNGAP - European Network on Understanding Gastrointestinal Absorption-related processes
COST Action CA16205
Other
Ongoing
2016 - 2019 Identification and assessment of new psychoactive substances: a European network
European Commission reference
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2013 - 2015 PopPK-PD of vancomicin on UCI patients
Null
Principal investigator
Universidade de Lisboa, Portugal
Ongoing
2012 - 2015 Pharmacokinetic/Pharmacogenetic modulation of HIV infection therapy by bayesian and artificial intelligence methods
PTDC/DTP-FTO/1747/2012
Researcher
Universidade de Lisboa, Portugal
Ongoing
2011/10 - 2012/09 PBPK models for development of new drugs
SFRH/BPD/69748/2010
Post-doc
Universidade de Lisboa, Portugal
Concluded
2006 - 2010 PBPK models of absorption
SFRH/BD/28545/2006
PhD Student Fellow
Universidade de Lisboa, Portugal
Concluded
1997 - 1999 Development of cationic lipossomes for DNA therapy
Praxis XXI nº 3/3.1/CTAE/1921/
Research Fellow
Laboratório Nacional de Energia e Geologia, Portugal
Concluded
1996 - 1997 Metabolism of Primaquine in the rat
PCIB/BIA/2047/95
Integration into Research Grant Fellow
Universidade de Lisboa, Portugal
Concluded
Outputs

Publications

Book
  1. Paixão, P.; Gouveia, L.; Guimarães Morais, J.A.; Silva, N.. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation: Modeling and functional extrapolation. Modeling and functional extrapolation.. 2016.
Book chapter
  1. Paixão, Paulo; Gouveia, Luís; Guimarães Morais, José Augusto; Silva, Nuno. "Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation". In Concepts and Models for Drug Permeability Studies, 357-371. Cambridge, UK: Elsevier, 2016.
    Published • 10.1016/B978-0-08-100094-6.00020-1
Conference abstract
  1. Paixão, Paulo; Custódio Fidalgo; Teresa Bugalho; Paulo Costa; Luis Marcelo Pereira. "Toxicokinetics of Paraquat in Human intoxicated Patients". Paper presented in I Congress of the Portuguese Society for the Pharmaceutical Sciences, Lisboa, 2003.
    Published
Conference paper
  1. Paixão, Paulo. "Aniceto, Natália; Gouveia, Luis F; Morais, José; Paixão, Paulo; In Silico prediction of the tissue:blood partition coefficient in the rat. In: NEW TRENDS IN PHARMACEUTICAL SCIENCES, 2011. Porto. Rev. Port. Farm.. 2011, v. 52, p. 85-86.". 2011.
  2. Paixão, Paulo. "2 Paixão, Paulo; Fidalgo, Custódio; Bugalho, Teresa; Costa, Paulo; Pereira, Luis Marcelo; Toxicokinetics of Paraquat in Human intoxicated Patients. In: I CONGRESS OF THE PORTUGUESE SOCIETY FOR THE PHARMACEUTICAL SCIENCES, 2003. Lisboa. Rev Port Farm. 2003, v. 52, p. 53.". 2003.
  3. Luis Constantino; Paixão, Paulo; Rui Moreira; Maria João Portela; Jim Iley; Vergílio do Rosário. "Evidence for MAO and Cyt P450 Involvement in the Oxidative Deamination of Primaquine to Carboxyprimaquine in Rat Liver". Paper presented in European Simposium on Medicinal Chemistry, Edinburgh, 1998.
    Published
Conference poster
  1. Paixão, Paulo. "Maiara Camotti Montanha, Conrado de Souza Alcantara, Thiago Ferreira dos Santos Magon, Sandra Regina Bin Silva, Cristina Megumi Kuroda, Sérgio Seiji Yamada, Daoud Nasser, Nelson Nardo Junior, Josmar Mazucheli, Andrea Diniz, Paulo Paixão, Elza Kimura Grimshaw. "Relative bioavailability of Amoxicillin tablets and suspension in RYGB bariatric subjects" in “3rd International Symposium on BA/BE of Oral". 2019.
  2. Paixão, Paulo. "Vera Domingos, Vera Pires, Sílvia Santos, Patrícia Trindade, Ana Inácio, Elza Candeias, Susana Simões, Paulo Paixão, Nuno Miranda, António Melo Gouveia. “optimization of the blood sampling procedure for busulfan therapeutic drug monitoring (TDM)” in 45th Congress Of The European Society For Blood And Marrow Transplantation. Frankfurt, Germany. (2019)". 2019.
  3. Paixão, Paulo. "Maiara Camotti Montanha, Conrado de Souza Alcantara, Thiago Ferreira dos Santos Magon, Sandra Regina Bin Silva, Cristina Megumi Kuroda, Sérgio Seiji Yamada, Daoud Nasser, Nelson Nardo Junior, Josmar Mazucheli, Andrea Diniz, Paulo Paixão, Elza Kimura Grimshaw. " Reduced oral bioavailability of Amoxicillin tablets compared to suspensions in RYGB bariatric subjects" in “UNGAP SPRING MEETING” Sofia, B". 2019.
  4. Paixão, Paulo. "Vera Domingos, Vera Pires, Sílvia Santos, Patrícia Trindade, Ana Inácio, Elza Candeias, Susana Simões, Paulo Paixão, Nuno Miranda, António Melo Gouveia. “PERSONALIZED BUSULFAN THERAPY: IMPLEMENTATION OF A THERAPEUTIC DRUG MONITORING PROGRAM (TDM)” in 23rd Congress of the European Association of Hospital Pharmacists. Gothenburg, Sweden. (2018)". 2018.
  5. Paixão, Paulo. "Vera Domingos, Vera Pires, Sílvia Santos, Patrícia Trindade, Ana Inácio, Elza Candeias, Susana Simões, Paulo Paixão, Nuno Miranda, António Melo Gouveia. “Implementação da monitorização farmacoterapêutica de bussulfano no Instituto Português de Oncologia de Lisboa” in X Congresso Nacional da APFH. Estoril, Portugal. (2017)". 2017.
  6. Paixão, Paulo. "Marival Bermejo, Yasuhiro Tsume, Paulo Paixão, Bart Hens, R Baker, Mark Koenigsknecht, Ann Frances, Bo Wen, T Zhao, Joseph Dickens, Alex Yu, M Pai, B Bleske, Jeffrey Wysocki, Kerby Shedden, Allen Lee, L Hassler, Duxin Sun, GL Amidon. “Linking Gastrointestinal In Vivo Dissolution and Ibuprofen Systemic Absorption” in 2017 AAPS Annual Meeting. San Diego, USA. (2017)". 2017.
  7. Paixão, Paulo. "Bart Hens, Yasuhiro Tsume, Marival Bermejo, Paulo Paixão, Mark Koenigsknecht, R Baker, L Hasler, Robert Lionberger, Jianghong Fan, Joseph Dickens, Kerby Shedden, Bo Wen, Jeffrey Wysocki, Raimar Löbenberg, Allen Lee, Ann Frances, E Amidon, Alex Yu, Gail Benninghoff, Niloufar Salehi, Arjang Talattof, Duxin Sun, GL Amidon. “Dynamic Change in pH by Low Buffer Capacity of Gastrointestinal Fluids Along". 2017.
  8. Paixão, Paulo. "Paulo Paixão, Marival Bermejo, Yasuhiro Tsume, Mark Koenigsknecht, Bart Hens, R Baker, Ting Zhao, Joseph Dickens, Alex Yu, Manjunath Pai, Barry Bleske, Jeffrey Wysocki, Kerby Shedden, Allen Lee, L Hasler, Duxin Sun, GL Amidon. “Connecting Gastrointestinal In Vivo Dissolution and Systemic Absorption of Oral Ibuprofen Administered After a Meal” in 2017 AAPS Annual Meeting. San Diego, USA. (2017)". 2017.
  9. Paixão, Paulo. "Zdovc J, Santos CF, Silva N, Morais JG, Paixão P. “Pharmacokinetics of vancomycin in intensive-care patients” in in Population Approach Group Europe Meeting 2016. Lisbon, Portugal. (2016)". 2016.
  10. Paixão, Paulo. "Duarte H, Mirco A, Paixão P, Morais JG, Falcão F, Silva N. “amikacin in premature neonates: a new therapeutic proposal from a poppk model” in Population Approach Group Europe Meeting 2016. Lisbon, Portugal. (2016)". 2016.
  11. Paixão, Paulo. "Fernandes, A. ; Cruz, J. P. ; Paixão, P. ; Valadas, E. ; Morais, J. G. ; Ribeiro, A. C.. “Pharmacogenetic: screening relevant polymorphisms on antiretroviral therapy in a HIV Portuguese population” in 15th European AIDS Conference. Barcelona, 21-24 October 2015, Spain. (2015)". 2015.
  12. Aniceto, Natália; Cruz, JP; Carvalho, C; Valadas, E; Paixão, Paulo; Marinho, R; Antunes, F; Morais, José A. G.. "IMPACT OF HEPATITIS C VIRUS ON THE HIV DISEASE PROGRESSION IN THE PORTUGUESE POPULATION". Paper presented in 9TH WORLD MEETING on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology, 2014.
  13. Aniceto, Natália; Gouveia, Luís F.; Morais, José A. G.; Paixão, Paulo. "ANNE for estimation of rat tissue-to-blood coefficients". Paper presented in 9TH WORLD MEETING on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology, 2014.
  14. Cruz, JP; Aniceto, Natália; Ribeiro, AC; Paixão, Paulo; Morais, José A. G.. "Population Pharmacokinetics-Pharmacogenetics of Efavirenz using Non-Linear Mixed Effects Modeling and Bayesian Estimation". Paper presented in PAGE 2014, 2014.
  15. Paixão, Paulo. "A Fernandes, N Aniceto, JP Cruz, P Paixão, E Valadas, JG Morais, AC Ribeiro. “Searching for the G516T Polymorphism on the CYP2B6 gene in HIV-1Patients” in International Young Researchers in Life Sciences Conference. Pasteur Institute, Paris, France, 26-28 May (2014).". 2014.
  16. Paixão, Paulo. "Cruz JP, Aniceto N, Ribeiro AC, Paixão P, Morais JG. “Population Pharmacokinetics-Pharmacogenetics of Efavirenz using Non-Linear Mixed Effects Modeling and Bayesian Estimation” in PAGE 2014. Alicante, Spain. (2014)". 2014.
  17. Paixão, Paulo; Aniceto, Natália; Morais, José A. G.; Gouveia, Luís F.; Natália Aniceto; Luis F Gouveia; José Morais. "In silico prediction of the tissue:blood partition coefficients in the rat". Paper presented in NEW TRENDS IN PHARMACEUTICAL SCIENCES, 2011.
  18. Paixão, Paulo; Luis F Gouveia; José Morais. "Evaluation of a physiologically based model to predict oral bioavailability using in vitro and in silico drug related parameters". Paper presented in International congress on new delivery systems, biosimilars, bioequivalence-biowaivers: Scientific, Industrial and Regulatory Aspects, 2010.
  19. Paixão, Paulo; Luis F Gouveia; José Morais. "Drug Bioavailability prediction using a Physiological model with in vitro and in vivo data - Congresso Nacional dos Farmacêuticos - Lisboa". Paper presented in Congresso Nacional dos Farmacêuticos, 2007.
  20. Paixão, Paulo; Luis F Gouveia; José Morais. "Estimation of human jejunal permeability using in silico derived parameters - Fine-Tuning the Physchem-Biopharmaceutical-ADME-Tox Profile - EUPHEBS - Zurique". Paper presented in Fine-Tuning the Physchem-Biopharmaceutical-ADME-Tox Profile, 2006.
  21. Paixão, Paulo; Luis F Gouveia; José Morais. "Use of molecular descriptors and neural networks for predicting effective permeability in Caco-2 - BioSim 1st Conference - BioSim - Palma de Maiorca". Paper presented in BioSim 1st Conference, 2005.
  22. Paixão, Paulo; Custódio Fidalgo; Teresa Bugalho; Paulo Costa; Luis Marcelo Pereira. "Toxicokinetics of Paraquat in Human intoxicated Patients - I Congress of the Portuguese Society for the Pharmaceutical Sciences - SPS - Lisboa". Paper presented in I Congress of the Portuguese Society for the Pharmaceutical Sciences, 2003.
  23. Paixão, Paulo; Ana Cristina Menezes; Sandra Simões; Luisa Corvo; Maria Eugénia Cruz. "Cationic liposomes as gene carriers in an E.coli model: effect of the preparation method and surface charge - CRS meeting - CRS - Sevilha". Paper presented in CRS meeting, 2002.
  24. Miguel Soares; Paixão, Paulo; Luis Marcelo Pereira; José Cabrita. "Populational phamarmacokinetic of cyclosporin in renal transplantation - PAGE meeting - PAGE - Basileia". Paper presented in PAGE meeting, 2001.
Journal article
  1. Paulo Paixão; Nuno Silva; Rita Bento Guerreiro; Kevin Blake; Milton Bonelli; José Augusto Guimarães Morais; Alfredo García-Arieta; Luís Filipe Gouveia. "Evaluation of a Proposed Approach for the Determination of the Bioequivalence Acceptance Range for Narrow Therapeutic Index Drugs in the European Union". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112349.
    10.3390/pharmaceutics14112349
  2. Gisela Myrian de Lima Leite Dalla Rosa; Sandra Regina Bin Silva; Sérgio Seiji Yamada; Paulo Jorge Pereira Alves Paixão; Maiara Camotti Montanha; Elza Kimura. "Amoxicillin dosing and pharmacokinetics in obesity for the treatment of bacterial respiratory infection secondary to COVID-19: a systematic review". Research, Society and Development (2022): https://doi.org/10.33448/rsd-v11i14.36040.
    10.33448/rsd-v11i14.36040
  3. Zvonimir Petric; Joao Goncalves; Paulo Paixao. "Under the Umbrella of Clinical Pharmacology: Inflammatory Bowel Disease, Infliximab and Adalimumab, and a Bridge to an Era of Biosimilars". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091766.
    10.3390/pharmaceutics14091766
  4. Paulo Paixão; Rita Bento Guerreiro; Nuno Silva; Kevin Blake; Milton Bonelli; Jose Augusto Guimarães Morais; Alfredo Garcia Arieta; Luis Filipe Gouveia. "A Proposed Approach for the Determination of the Bioequivalence Acceptance Range for Narrow Therapeutic Index Drugs in the European Union". Clinical Pharmacology & Therapeutics (2022): https://doi.org/10.1002/cpt.2451.
    10.1002/cpt.2451
  5. Paixão, Paulo. "Pharmacokinetics of amoxicillin in obese and nonobese subjects.". British journal of clinical pharmacology (2021): https://doi.org/10.1111/bcp.14739.
    10.1111/bcp.14739
  6. Vera M. S. Isca; Joana Andrade; Ana S Fernandes; Paulo Paixão; Clara Uriel; Ana Maria Gomez; Duarte, N; Patricia Rijo. "In Vitro Antimicrobial Activity of Isopimarane-Type Diterpenoids". Molecules (2020): https://www.mdpi.com/1420-3049/25/18/4250.
    10.3390/molecules25184250
  7. Paixão, Paulo. "Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2020): https://doi.org/10.1016/j.ejps.2020.105517.
    10.1016/j.ejps.2020.105517
  8. Paixão, Paulo. "A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP.". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12010074.
    10.3390/pharmaceutics12010074
  9. Paixão, Paulo. "Physiologically-Based Pharmacokinetic Model on the Oral Drug Absorption in Roux-en-Y Gastric Bypass Bariatric Patients: Amoxicillin Tablet and Suspension.". Molecular pharmaceutics (2019): https://doi.org/10.1021/acs.molpharmaceut.9b00870.
    10.1021/acs.molpharmaceut.9b00870
  10. Paixão, Paulo. "Report from the “3rd International Symposium on BA/BE of Oral Drug Products: Biopharmaceutics meets Galenics”". Journal of Drug Delivery Science and Technology (2019): http://dx.doi.org/10.1016/j.jddst.2019.101274.
    10.1016/j.jddst.2019.101274
  11. Paixão, Paulo. "Reduced bioavailability of oral amoxicillin tablets compared to suspensions in Roux-en-Y gastric bypass bariatric subjects.". British journal of clinical pharmacology (2019): https://doi.org/10.1111/bcp.14023.
    10.1111/bcp.14023
  12. Paixão, Paulo. "Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.". Molecular pharmaceutics (2018): https://doi.org/10.1021/acs.molpharmaceut.8b00736.
    10.1021/acs.molpharmaceut.8b00736
  13. Paixão, Paulo. "Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.". Molecular pharmaceutics (2018): https://doi.org/10.1021/acs.molpharmaceut.8b00515.
    10.1021/acs.molpharmaceut.8b00515
  14. Paixão, Paulo. "Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.". International journal of pharmaceutics (2018): https://doi.org/10.1016/j.ijpharm.2018.06.050.
    10.1016/j.ijpharm.2018.06.050
  15. Paixão, Paulo. "Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach.". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2018): https://doi.org/10.1016/j.ejpb.2018.05.033.
    10.1016/j.ejpb.2018.05.033
  16. Paixão, Paulo. "Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model.". The AAPS journal (2018): https://doi.org/10.1208/s12248-018-0217-6.
    10.1208/s12248-018-0217-6
  17. Paixão, Paulo. "Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages.". Pharmaceutical research (2018): https://europepmc.org/articles/PMC6362828.
    10.1007/s11095-018-2391-8
  18. Cardot, J.-M.; Garcia-Arieta, A.; Paixao, P.; Tasevska, I.; Davit, B.. "Implementing the additional strength biowaiver for generics: EMA recommended approaches and challenges for a US-FDA submission". European Journal of Pharmaceutical Sciences 111 (2018): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032861558&partnerID=MN8TOARS.
    10.1016/j.ejps.2017.10.013
  19. Hens, B.; Al-Gousous, J.; Wang, K.; Salehi, N.; Ziff, R.M.; Tsume, Y.; Bermejo, M.; et al. "Summary of the in vivo predictive dissolution (iPD) – oral drug delivery (ODD) conference 2018". Dissolution Technologies 25 2 (2018): 50-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051654799&partnerID=MN8TOARS.
    10.14227/DT250218P50
  20. Paixão P; Gouveia LF; Silva N; Morais JA. "Evaluation of dissolution profile similarity - Comparison between the f2, the multivariate statistical distance and the f2 bootstrapping methods.". (2017): http://europepmc.org/abstract/med/27865857.
    10.1016/j.ejpb.2016.10.026
  21. Duarte, H.; Cruz, J.P.; Aniceto, N.; Ribeiro, A.C.; Fernandes, A.; Paixão, P.; Antunes, F.; Morais, J.. "Population Approach to Efavirenz Therapy". Journal of Pharmaceutical Sciences 106 10 (2017): 3161-3166. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026645839&partnerID=MN8TOARS.
    10.1016/j.xphs.2017.06.004
  22. Hens, B.; Tsume, Y.; Bermejo, M.; Paixao, P.; Koenigsknecht, M.J.; Baker, J.R.; Hasler, W.L.; et al. "Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs". Molecular Pharmaceutics 14 12 (2017): 4281-4294. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037621073&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00426
  23. Cardot, J.-M.; Garcia Arieta, A.; PAIXAO, P; Tasevska, I.; Davit, B.. "Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches". The AAPS Journal 18 4 (2016): 1039-1046.
    Published • 10.1208/s12248-016-9915-0
  24. Paixão, Paulo; Aniceto, Natália; Gouveia, Luís F.; Morais, José A. G.. "Prediction of Drug Distribution in Rat and Humans Using an Artificial Neural Networks Ensemble and a PBPK Model". Pharmaceutical Research 31 12 (2014): 3313-3322.
    Published • 10.1007/s11095-014-1421-4
  25. Paixão, Paulo; Aniceto, Natália; Gouveia, Luís F.; Morais, José A.G.. "Tissue-to-blood distribution coefficients in the rat: Utility for estimation of the volume of distribution in man". European Journal of Pharmaceutical Sciences 50 3-4 (2013): 526-543.
    Published • 10.1016/j.ejps.2013.08.020
  26. Paixão, Paulo; Gouveia, Luís F.; Morais, José A.G.. "An alternative single dose parameter to avoid the need for steady-state studies on oral extended-release drug products". European Journal of Pharmaceutics and Biopharmaceutics 80 2 (2012): 410-417.
    Published • 10.1016/j.ejpb.2011.11.001
  27. Paixão, Paulo; Gouveia, Luís F.; Morais, José A.G.. "Prediction of the human oral bioavailability by using in vitro and in silico drug related parameters in a physiologically based absorption model". International Journal of Pharmaceutics 0 0 (2012): 0-0.
    Published • 10.1016/j.ijpharm.2012.03.019
  28. Paixão, Paulo; Gouveia, Luís F.; Morais, José A.G.. "Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks". European Journal of Pharmaceutical Sciences 39 5 (2010): 310-321.
    Published • 10.1016/j.ejps.2009.12.007
  29. Paixão, Paulo; Gouveia, Luís F.; Morais, José A.G.. "Prediction of the in vitro permeability determined in Caco-2 cells by using artificial neural networks". European Journal of Pharmaceutical Sciences 41 1 (2010): 107-117.
    Published • 10.1016/j.ejps.2010.05.014
  30. Paixão, Paulo; Gouveia, Luís F.; Morais, José A.G.. "Prediction of drug distribution within blood". European Journal of Pharmaceutical Sciences 36 4-5 (2009): 544-554.
    Published • 10.1016/j.ejps.2008.12.011
  31. Paixão, Paulo. "Use of artificial neural networks for outcome prediction in paraquat intoxications Model". Revista Lusófona de Ciências e Tecnologias de Saúde 2 1 (2006): 85-92. http://revistas.ulusofona.pt/index.php/revistasaude/article/view/16.
    Published
  32. PAIXAO, P; COSTA, P; BUGALHO, T; FIDALGO, C; PEREIRA, L. "Simple method for determination of paraquat in plasma and serum of human patients by high-performance liquid chromatography". Journal of Chromatography B 775 1 (2002): 109-113.
    Published • 10.1016/S1570-0232(02)00245-3
  33. Constantino, L.; Paixão, P.; Moreira, R.; Portela, M.J.; Do Rosario, V.E.; Iley, J.. "Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine". Experimental and Toxicologic Pathology 51 4-5 (1999): 299-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032781772&partnerID=MN8TOARS.
    Published
Newsletter article
  1. Paixão, Paulo. "Paulo Paixão “Aprovação Regulamentar De Vacinas COVID-19”", Saúde Com Todos, Boletim Informativo De Saúde Pública, Unidade de Saúde Pública do ACeS Pinhal Interior Norte, 2021, https://tinyurl.com/saudecomtodosjanfev.

Other

Other output
  1. Paixão, Paulo (Tese de Doutoramento). In Silico Prediction of Human Oral Bioavailability. Artificial Neural Networks and Physiologically Based Models. Lisboa: Universidade de Lisboa, 2010. URI: http://hdl.handle.net/10451/2232. 2010. Paixão, Paulo.
  2. Paixão, Paulo (Tese de Mestrado). Estudo da Toxicocinética do Paraquato em Doentes Humanos Intoxicados. Lisboa: Universidade de Lisboa, 2002.. 2002. Paixão, Paulo.
  3. Paixão, Paulo (Tese de Licenciatura). Estudo in vitro do Metabolismo do Anti-Malárico Primaquina. Lisboa: Universidade de Lisboa, 1997.. 1997. Paixão, Paulo.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Paixão, Paulo. “Regulatory use of M&S” in “Workshop RedIF 2020 – Introdutory Course on Pharmacometrics”. Online, October 14 - 16, 2020.
2019 Paixão, Paulo. “Dissolution profile comparison using different statistical approaches – f2 bootstrapping” in “BioBridges 2019”. Charles University, Prague, September 26 - 27, 2019
2018 Individualização do tratamento com bussulfano: implementação de um programa de monitorização farmacoterapêutica X jornadas de farmácia hospitalar da ordem dos farmacêuticos
2018 Vera Domingos, Paulo Paixão, Nuno Miranda, Margarida Pereira, Vera Pires, Ana Sofia Jorge, Elsa Oliveira, António Melo Gouveia, Manuel Abecasis. “Busulfan: from the bench to the bedside” in “3rd pharmacist day, 44th congress of the european society for blood and marrow transplantation” Lisboa, 2018 3rd pharmacist day, 44th congress of the european society for blood and marrow transplantation
2018 1. Maiara Camotti Montanha, Conrado de Souza Alcantara, Thiago Ferreira dos Santos Magon, Sandra Regina Bin Silva, Cristina Megumi Kuroda, Sérgio Seiji Yamada, Daoud Nasser, Nelson Nardo Junior, Josmar Mazucheli, Andrea Diniz, Paulo Paixão, Elza Kimura Grimshaw. "Relative bioavailability of Amoxicillin tablets and suspension in RYGB bariatric subjects" in “3rd International Symposium on BA/BE of Oral Drug Products” Lisbon, 2018 3rd International Symposium on BA/BE of Oral Drug Products
2018 Paixão, Paulo. “Mathematical modelling in gastric emptying and intestinal drug levels (Fed state)” in “Modelbio - Jornadas de modelización y simulación en biomedicina 2018”. Universidad Miguel Hernández. Alicante, Spain. 2018.
2018 Paixão, Paulo. “Gastrointestinal, Plasma Levels and motility: Ibuprofen Fed” in “Oral Drug Delivery (ODD) 2018 in vivo Predictive Dissolution (iPD), formulation Predictive Dissolution (fPD)”. Drug Delivery Foundation. Lake Tahoe, NV, USA. 2018.
2015 Paixão, Paulo. “Modeling and simulation on the preparation of a bioequivalence demonstration” in “2ND MENA REGULATORY CONFERENCE ON BIOEQUIVALENCE, BIOWAIVERS, BIOANALYSIS, DISSOLUTION AND BIOSIMILARS”. AAPS, FIP, TUFTAD and IPRC. Amman, Jordan. 2015
2015 Paixão, Paulo. “Applying physiologically based pharmacokinetic modelling for in vitro in vivo correlation (IVIVC) to support bioequivalence (BE) applications” in “Bioavailability/Bioequivalence, Dissolution and Biowaivers”. Informa Life Sciences. Prague, Czech Republic. 2015.
2014 Paixão, Paulo. “Assessing the use of pharmacokinetic simulators to know your drug and prepare a bioequivalence study” in “Bioavailability/Bioequivalence, Dissolution and Biowaivers”. Informa Life Sciences. Budapest, Hungary. 2014.
2013 Paixão, Paulo. “Understanding the new requirements for bioequivalence studies” in “Modified Release in Oral Drug Delivery”. Informa Life Sciences. Berlin, Germany. 2013.
2013 Paixão, Paulo. “Examining the use of pharmacokinetic simulations for BABE applicants” in “Bioavailability/Bioequivalence, Dissolution and Biowaivers”. Informa Life Sciences. Budapest, Hungary. 2013.
2013 Paixão, Paulo. “Modeling and Simulation on Pharmacokinetics” in “CBiOS Science Sessions”. CBIOS. Lisbon, Portugal. 2013.
2013 Paixão, Paulo. “in silico Models in the Development of New Drugs” in “International Conference Of Alternatives to Animal Experimentation”. SPEdH. Almada, Portugal. 2013.
2012 Paixão, Paulo. “Exploring the use of Modeling and simulation for regulatory decision” in “Innovations of Modified Release”. Informa Life Sciences. Munique, Alemanha. 2012.
2011 Natália Aniceto; Luis F Gouveia; José Morais; Paixão, Paulo. “In silico prediction of the tissue:blood partition coefficients in the rat” in “New Trends In Pharmaceutical Sciences”. Portuguese Society of Pharmaceutical Sciences. Porto, Portugal. 2011. New Trends In Pharmaceutical Sciences
2011 Paixão, Paulo. “Understanding the regulatory perspective on Biowaivers” in “Bioavailability, Bioequivalence and Dissolution Testing”. Informa Life Sciences. Budapeste, Hungria. 2011.
2011 Natália Aniceto; Luis F Gouveia; José Morais; Paixão, Paulo. “In silico prediction of the tissue:blood partition coefficients in the rat” in “NEW TRENDS IN PHARMACEUTICAL SCIENCES”. Portuguese Society of Pharmaceutical Sciences. Porto, Portugal. 2011.
1998 Evidence for MAO and Cyt P450 Involvement in the Oxidative Deamination of Primaquine to Carboxyprimaquine in Rat Liver - XVI European Wokshop on Drug Metabolism - Copenhaga XVI European Wokshop on Drug Metabolism
(Copenhaga, Denmark)
1998 Paixão, Paulo; Luis Constantino; Rui Moreira; Jim Iley; Vergílio do Rosário. “Evidence for MAO and Cyt P450 Involvement in the Oxidative Deamination of Primaquine to Carboxyprimaquine in Rat Liver” in “XVI European Wokshop on Drug Metabolism”. European Society for Biochemical Pharmacology. Copenhaga, Dinamarca. 1998.

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - 2020 Medicamentos genéricos em Portugal. Dos requisitos regulamentares até ao utente – 30 anos depois
Supervisor
 Ciências Farmacêuticas (Master)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2020 - 2020 Target Mediated Disposition of Rituximab in Diffuse Large B-Cell Lymphoma: A Population Pharmacokinetic Analysis
Co-supervisor
 Ciências Farmacêuticas (Master)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2020 - 2020 Opponent at the Masters of Rita Bento Guerreiro. "Narrow therapeutic range drug products. Challenges in the assessment of Bioequivalence. The role of Modelling and Simulations and expert systems"
Supervisor
 Ciências Farmacêuticas (Master)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2017 - 2019 Relative bioavailability of Amoxicillin tablets and suspension in RYGB bariatric subjects
Co-supervisor
 Pharmacokinetics (PhD)
Universidade Estadual de Maringá, Brazil
2016 - 2016 Monitorização terapêutica individualizada de bussulfano em doentes sob regimes de condicionamento pré-transplante de células progenitoras hematopoiéticas no IPO de Lisboa
Supervisor
 Mestrado em Farmacoterapia e Farmacoepidemiologia (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 Development of a mechanistic model for drug-induced liver injury (DILI)
Co-supervisor
 Mestrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 Preparação de uma demonstração de bioequivalência para comprimidos de libertação imediata de Furosemida
Supervisor
 Mestrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 PopPK models of Vancomycin in ICU patients: Comparison between ADAPT 5 and NONMEM 7 results
Co-supervisor
 Pharmacy (Master)
Univerza v Ljubljani, Slovenia
2016 - 2016 Monitorização terapêutica individualizada de bussulfano em doentes sob regimes de condicionamento pré-transplante de células progenitoras hematopoiéticas no IPO de Lisboa
Supervisor
 Farmacoterapia e Farmacoepidemiologia (Master)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2015 - 2015 Predictive Models of hepatic clearance
Supervisor
 Mestrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2015 Pharmacokinetics of Vancomycin in ICU patients
Supervisor
 Mestrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Pharmacokinetic modeling. Using rat data for QSAR modeling
Supervisor
 disciplina de Projecto II (Other)
Universidade de Lisboa, Portugal
2014 - 2014 Bioequivalencia de formulaçoes de libertaçao prolongada
Supervisor
 Ciências Farmacêuticas (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2014 - 2014 Farmacocinética dos anti-maláricos na população infantil
Supervisor
 Ciências Farmacêuticas (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2013 - 2013 QSAR models for plasma protein buinding
Supervisor
 Ciências Farmaceuticas (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2013 - 2013 Use of PBPK for drug development
Supervisor
 Ciências Farmacêuticas (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 - 2011 Determinação in silico do coeficientes de partilha tecido:sangue para previsão do volume de distribuição de fármacos
Supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/10/11 - 2018/10/12 3rd International Symposium on BA/BE of Oral Drug Products - Biopharmaceutics meets Galenics (BA/BE 2018) FIP’s Bioavailability/Bioequivalence Focus Group. Co-sponsored by INFARMED’s 25+ event (2018/10/11 - 2018/10/12)
Symposium (President of the Organising Committee)
2016/07 - 2016/07 PAGE Meeting 2016 Population Approach Group Europe Meeting. Lisboa, Portugal. 2016 (2016 - 2016)
Congress (Member of the Organising Committee)
2016 - 2016 SCIENTIFIC AND REGULATORY ISSUES IN DRUG DEVELOPMENT AND BIOEQUIVALENCE. Portuguese Society for Pharmaceutical Sciences. Lisboa, Portugal. 2016. (2016 - 2016)
Symposium (Member of the Scientific Committee)
2015 - 2015 2nd Mena Regulatory Conference On Bioequivalence, Biowaivers, Bioanalysis, Dissolution And Biosimilars AAPS, FIP, TUFTAD and IPRC. Amman, Jordan. 2015. (2015 - 2015)
Conference (Other)
2012 - 2012 Evaluation of multiphasic MR products Informa Life Sciences. Munique, Alemanha. 2012. (2012 - 2012)
Symposium (Other)
2011 - 2011 New Regulatory Developments in Pharmacokinetic Assessment
Symposium (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2014 - 2014 Assessing the use of pharmacokinetic simulators to know your drug and prepare a bioequivalence study
Congress
 Bioavailability/Bioequivalence, Dissolution and Biowaivers
Informa Life Sciences, Hungary
2013 - 2013 in silico Models in the Development of New Drugs
Congress
 International Conference Of Alternatives to Animal Experimentation
SPEdH, Portugal
2013 - 2013 Modeling and Simulation on Pharmacokinetics
Seminar
 CBiOS Science Sessions
CBiOS, Portugal
2013 - 2013 Examining the use of pharmacokinetic simulations for BABE applicants
Congress
 Bioavailability/Bioequivalence, Dissolution and Biowaivers
Informa Life Sciences, Hungary
2013 - 2013 Understanding the new requirements for bioequivalence studies
Congress
 Drug Delivery Summit - Modified Release in Oral Drug Delivery
Informa Life Sciences, Germany
2012 - 2012 Exploring the use of Modeling and simulation for regulatory decision
Congress
 Innovations of Modified Release
Informa Life Sciences, Germany
2012 - 2012 Evaluation of multiphasic MR products
Seminar
 Meeting bioequivalence (BE) modified release requirements and practical advice for successful BE studies
Informa Life Sciences, Germany
2011 - 2011 Understanding the regulatory perspective on Biowaivers
Conference
 Bioavailability, Bioequivalence and Dissolution Testing
Informa Life Sciences, Hungary
2011 - 2011 New Regulatory Developments in Pharmacokinetic Assessment
Symposium
 New Regulatory Developments in Pharmacokinetic Assessment
PORTUGUESE SOCIETY OF PHARMACEUTICAL SCIENCES, Portugal
2011 - 2011 EMA EFPIA Modelling and Simulation Workshop
Workshop
 EMA EFPIA Modelling and Simulation Workshop
European Medicines Agency and the European Federation of Pharmaceutical Industries and Associations, United Kingdom
2011 - 2011 New Trends in Pharmaceutical Sciences
Congress
 New Trends in Pharmaceutical Sciences
Portuguese Society of Pharmaceutical Sciences (SPCF) and the Spanish-Portuguese Local Chapter of Controlled Release Society (SPLC-CRS), Portugal
2010 - 2010 Workshop RNA therapeutics
Workshop
 Workshop RNA therapeutics
Harvard Medical School Portugal Program, Portugal
2010 - 2010 International congress on new delivery systems, biosimilars, bioequivalence-biowaivers: Scientific, Industrial and Regulatory Aspects
Congress
 International congress on new delivery systems, biosimilars, bioequivalence-biowaivers: Scientific, Industrial and Regulatory Aspects
2008 - 2008 Modeling and data analysis in pharmacokinetics and pharmacodynamics using ADAPT 5
Meeting
2008 - 2008 2nd EGA-CMD(h) SYMPOSIUM ON BIOEQUIVALENCE
Conference
 2nd EGA-CMD(h) SYMPOSIUM ON BIOEQUIVALENCE
EGA, France
2008 - 2008 Biosim - Biosimulation Board Meeting
Meeting
 Extended Board Meeting
Biosim, Netherlands
2007 - 2007 Hands-on Experience with automated in vitro-in vivo extrapolation using SimCYP
Workshop
2007 - 2007 Congresso Nacional dos Farmacêuticos
Congress
 Congresso Nacional dos Farmacêuticos
Ordem dos Farmaceuticos, Portugal
2007 - 2007 1st EGA Workshop on Bioequivalence
Conference
 1st EGA Workshop on Bioequivalence
EGA, Portugal
2006 - 2006 Fine-Tuning the Physchem-Biopharmaceutical-ADME-Tox Profile
Conference
 Fine-Tuning the Physchem-Biopharmaceutical-ADME-Tox Profile
EUPHEBS, Switzerland
2003 - 2003 Expert meeting on Validation of in Silico Approaches to the Prediction of Gastrointestinal Absorption and Drug Metabolism
Round table
 Expert meeting on Validation of in Silico Approaches to the Prediction of Gastrointestinal Absorption and Drug Metabolism
COST B15, Belgium
2003 - 2003 The New European CPMP and US FDA Notes for Guidance on Bioavailability and Bioequivalence – Experience and Prespectives
Congress
2003 - 2003 1º congresso da Sociedade Portuguesa de Ciências Farmacêuticas
Congress
Sociedade Portuguesa de Ciências Farmacêuticas, Portugal
2001 - 2001 Curso Practico en analisis farmacocinetico poblacional: programa NONMEM
Workshop
 Curso Practico en analisis farmacocinetico poblacional: programa NONMEM
Dept. Farmacologia da Faculdade de Medicina e Odontologia da Universidade do Pais Basco, Spain
2001 - 2001 2ª Jornadas da Sociedade Portuguesa de Ciências Farmacêuticas
Congress
Sociedade Portuguesa de Ciências Farmacêuticas, Portugal
2001 - 2001 PAGE Meeting
Congress
Population Approach Group Europe, Switzerland
1999 - 1999 Liposomal drug-carriers: solving problems of drug delivery
Conference
1999 - 1999 Targeting of Drugs: Strategies for gene Constructs and Delivery
Congress
Nato Advanced Studies Institute, Greece
1999 - 1999 2nd Short Course of the Portuguese Biophysical Society Simulation of Biological Processes. Practical approaches
Seminar
Sociedade Portuguesa de Biofísica, Portugal
1998 - 1998 III Spanish-Portuguese conference on controlled drug delivery
Conference
1998 - 1998 Particle size determination by photoelectronic spectroscopy
Seminar
Dias de Sousa, Portugal
1997 - 1997 Electroforese capilar
Seminar
UNICAM, Portugal
1996 - 1996 Diferenciação, Desenvolvimento e Carcinogénese
Seminar

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Opponent at the PhD of Alejandro Ruis Picazo. “Influencia de los excipientes en la Biodisponibilidade Oral”. (2020). Universitas Miguel Hernández. Spain
(Thesis) Main arguer
 Alejandro Ruis Picazo (PhD)
2020 Opponent at the Masters of Ana Catarina Monteiro Guerra. “Farmacocinética, farmacodinâmica e monitorização sérica de ß-lactâmicos”. Mestrado Integrado em Ciências Farmacêuticas – Faculdade de Farmácia, Lisbon University (2020)
(Thesis) Main arguer
 Ana Catarina Monteiro Guerra (Master)
2020 Opponent at the Masters of Tiago Borges Janela. “Is artificial intelligence able to predict the palatability of pediatric medicines?”. Mestrado Integrado em Ciências Farmacêuticas – Faculdade de Farmácia, Lisbon University (2020)
(Thesis) Main arguer
 Tiago Borges Janela (Master)
2020 Opponent at the Masters of Inês Sousa Pinto Ferreira. “Farmacocinética e monitorização das concentrações séricas do tacrolimus”. Mestrado Integrado em Ciências Farmacêuticas – Faculdade de Farmácia, Lisbon University (2020)
(Thesis) Main arguer
 Inês Sousa Pinto Ferreira (Master)
2019 Opponent at the PhD in Chemistry of Adrián Hernández Teruel. “Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy”. (2019). Universitat Politècnica de València. Spain
(Thesis) Main arguer
 Adrián Hernández Teruel (PhD)
2019 Opponent at the PhD of Larissa Lachi Silva. ¿Farmacometria aplicada a revisão de doses de bromoprida em populações especiais¿. (2019). PhD em Ciências Farmacêuticas. UNIVERSIDADE ESTADUAL DE MARINGÁ.
(Thesis) Main arguer
 Larissa Lachi Silva (PhD)
Universidade Estadual de Maringá, Brazil
2015 Opponent at the PhD of João Paulo Garcia Lopes da Cruz. “Impacto da farmacogenética na farmococinética dos antirretrovíricos em doentes coinfetados por vírus da imunodeficiência humana (VIH) e vírus da hepatite B (VHB) e/ou vírus da hepatite C (VHC)”. (2015). Universidade de Lisboa. Portugal João Paulo Garcia Lopes da Cruz (PhD)
2015 Opponent at the Masters of Almir Germano. “Correlação entre balanço hídrico e a concentração de vancomicina em pacientes com sepse internados na UTI do Hospital Universitário de Maringá”. (2015). Universidade Estadual de Maringá. Brasil
(Thesis) Main arguer
 Almir Germano (Master)
2014 Opponent at the Master's of Ana Alexandra da Conceição Mirco Fernandes on "Farmacocinética da arnicacina no recérn-nascido prematuro" Ana Alexandra da Conceição Mirco Fernandes (Master)
Universidade de Lisboa, Portugal
2012 Opponent at the PhD of Nuno Miguel Neves Elvas Silva on "Modeling and Simulation on Bioequivalence" Nuno Miguel Neves Elvas Silva (PhD)
Universidade de Lisboa, Portugal
2011 Opponent at the Masters of Leila Vanessa Carmo Cardoso Martins Costa. "Estudo da farmacocinética do Meropenem em doentes com sepsis grave" Leila Vanessa Carmo Cardoso Martins Costa (Other)
Universidade de Lisboa, Portugal
2011 Opponent at the PhD of Maria Margarida André Oliveira Estudante. "Predicting transporter effects on the pharmacokinetics of metabolized drugs" Maria Margarida André Oliveira Estudante (PhD)
Universidade de Lisboa, Portugal
2011 Opponent at the Masters of Nuno Rodrigues Martinho. "Avaliação de uma formulação de nanoparticulas de poli(D,L-láctico-co-glicólico) contendo ácido azelaico para o tratamento do acne" Nuno Rodrigues Martinho (Other)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 Opponent at the Masters of Catarina Oliveira Silva. "Avaliação de uma formulação de nanoparticulas de poli(¿-caprolactona) contendo acetato de hidrocortisona para o tratamento da dermatite atópica" Catarina Oliveira Silva (Other)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 Opponent at the Masters of Natália Moura Aniceto. "Determinação in silico do coeficientes de partilha tecido:sangue para previsão do volume de distribuição de fármacos" Natália Moura Aniceto (Other)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2007 Opponent at the Masters of Maria Inês Antunes Barata. "Modulação dos Citocromos P450 2E1 e 2A hepáticos do rato induzidas por separação maternal e administração de etanol" Maria Inês Antunes Barata (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Uppsala Universitet, Sweden
2007 Opponent at the Masters of Sara Filipa de Ornelas Valente Ramos. "Distribuição da ciprofloxacina através da barreira hemato-encefálica dos ratos" Sara Filipa de Ornelas Valente Ramos (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Uppsala Universitet, Sweden

Association member

Society Organization name Role
2013/01 - Current American Association of Pharmaceutical Scientists
2002/01 - Current Conselho Científico da FCTS
2002/01 - Current Conselho Pedagógico da FCTS
2006/09 - 2010/12 Conselho Científico da ERISA
2006/09 - 2010/12 Conselho Pedagógico da ERISA

Committee member

Activity description
Role 		Institution / Organization
2020 - Current Conselho Fiscal da FARM-ID
Member
2019/11 - Current Pharmacokinetics Working Party (PKWP) na Agencia Europeia do Medicamento
Member
2013 - Current Comissão de Avaliação de Medicamentos (CAM) no INFARMED, IP
Member
2012 - 2018 Ethical Committee at Escola de Ciências e Tecnologias da Saúde da Universidade Lusófona de Humanidades e Tecnologias
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012/09 - Current Farmacocinética e Biogalénica (Outros) Universidade de Lisboa Faculdade de Farmácia, Portugal
2001/09 - Current Biofarmácia Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - Current Farmacocinética Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - Current Biologia Celular I Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - Current Biologia Celular II Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - Current Bioquímica Geral Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/09 - Current Biodisponibilidade e Bioequivalência Ciências Farmacêuticas (Outros) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2010 - 2010 Aula sobre modelos não compartimentais e modelação farmacocinética no Mestrado de Engenharia Farmaceutica Especialização (Curso médio) Faculdade de Farmácia da Universidade de Lisboa, Portugal
2010 - 2010 Aula sobre Farmacocinética de Base fisiológica na disciplina de Biofarmácia e Farmacocinética na FFUL Especialização (Curso médio) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2009 Aula sobre Farmacocinética de Base fisiológica na disciplina de Biofarmácia e Farmacocinética na FFUL Especialização (Curso médio) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2008 Aula sobre Farmacocinética de Base fisiológica na disciplina de Biofarmácia e Farmacocinética na FFUL Especialização (Curso médio) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2006 Aula sobre metodologias para análise e tratamento de dados farmacocinéticos na 2ª edição do mestrado “Regulação e avaliação de medicamentos e Produtos de Saúde” Especialização (Curso médio) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2005 Aula de Biodisponibilidade e bioequivalência na 1ª edição da Pós-graduação em “Monitorização de Ensaios Clínicos” Especialização (Curso médio) Departamento de Ciências de Saúde da ULHT, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020 - Current Evaluator in the remote assessment process selection (INPhINIT) in the “la Caixa” Fellowship Programme (2020)
Evaluator

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Journal of Personalized Medicine
2020 - Current Antibiotics
2020 - Current CNS Drugs
2020 - Current Comprehensive Reviews in Food Science and Food Safety
2020 - Current European Journal of Pharmaceutics and Biopharmaceutics
2020 - Current Pharmaceutics
2020 - Current Scientifica
2019 - Current AAPS PharmSciTech
2019 - Current Basic and Clinical Pharmacology and Toxicology
2019 - Current Current Pharmaceutical Biotechnology
2019 - Current International Journal for Numerical Methods in Biomedical Engineering
2019 - Current Journal of chemical Information and Modeling
2019 - Current Journal of Drug Delivery Science and Technology
2018 - Current Current Drug Therapy
2018 - Current International Journal of Pharmaceutics
2018 - Current Molecular Pharmaceutics
2017 - Current Drug Development and Industrial Pharmacy
2017 - Current Journal of Pharmacy and Pharmacology
2016 - Current Pharmaceutical Research
2016 - Current AAPS Journal
2015/02/23 - Current Journal of Bioequivalence Studies Annex Publishers
2014/10/22 - Current Mini-Reviews in Medicinal Chemistry Bentham Science
2014/10/21 - Current Regulatory Toxicology and Pharmacology Elsevier wordmark
2012/05/18 - Current Current Pharmaceutical Analysis Bentham Science
Current BMC Pharmacology and Toxicology
Current Drug Design, Development and Therapy
2013/01/26 - 2015/01/01 Journal of Medical and Pharmaceutical Innovation Literati Scientific and Publishers
2012/06/22 - 2013/06/27 Arzneimittelforschung DrugResearch Thieme Publishers
Distinctions

Award

2021 Prémio Mantero Belard (as team participant)
Santa Casa da Misericórdia de Lisboa, Portugal
2017 Prémio Prof. Doutor Aluísio Marque Leal (as supervisor)
Associação Portuguesa de Farmacêuticos Hospitalares, Portugal
2012 Outstanding Manuscript Award in Modeling and Simulation
AAPS - American Association of Pharmaceutical Scientists, Portugal

Other distinction

2014 BInov 2014 (as supervisor)
Secção Regional de Lisboa da Ordem dos Farmacêuticos, Portugal