???global.info.a_carregar???
Mariana Reis-Sobreiro completed her undergraduate studies in Biology in 2008 at Faculdade de Ciências da Universidade de Coimbra. She finished her PhD in Cancer Biology and therapeutics in 2013 at Instituto de Investigación del Cáncer - University of Salamanca. She is currently a Postdoc at Instituto de Medicina Molecular João Lobo Antunes. Published 10 articles in journals with over 550 citations. She has presented her work in National and International Conferences in poster or oral presentation format for more than 15 times including invited lectures. Supervises 1 MSc student. She have been invited as PhD examiner at Portuguese and Spanish academic institutions. She works in the area of Medical and Health Sciences with emphasis on Immunotherapy, Oncobiology, Metastasis and Tumor Microenvironment.
Read full resume ↓
Identification

Personal identification

Full name
Mariana Reis Sobreiro

Citation names

  • Reis-Sobreiro, Mariana

Author identifiers

Ciência ID
D111-9AA5-1E27
ORCID iD
0000-0003-0286-0824

Email addresses

  • mariana.sobreiro@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • 217 999 41 (Professional)

Addresses

  • Av. Prof. Egas Moniz, 1649-028 Lisboa, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2013/07/18
Concluded
 Cancer biology and therapeutics (Doctor)
Universidad de Salamanca, Spain

Instituto de Investigación del Cáncer, Spain
"Lipid rafts in cancer chemotherapy" (THESIS/DISSERTATION)
 Sobresaliente
2009/07/07
Concluded
 Cancer biology and therapeutics (DEA)
Universidad de Salamanca, Spain

Instituto de Investigación del Cáncer, Spain
Sobresaliente
2008/10/28
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2018/12/12 - Current Postdoc (Research) Instituto de Medicina Molecular, Portugal
2013/09/02 - 2018/12/05 Postdoc (Research) Cedars-Sinai Medical Center, United States
Cedars-Sinai Medical Center, United States
Projects

Grant

Designation Funders
2015/09/01 - 2017/09/01 Does the Loss of Stromal Caveolin-1 Remodel the Tumor Microenvironment by Activating Src-Mediated PEAK1 and PI3K Pathways? Grant $124,050.00
W81XWH-15-1-0473
Post-doc Fellow
U.S. Army Medical Research and Materiel Command, United States
 U.S. Army Medical Research and Materiel Command
Concluded
2015/09 - 2017/09 Does the Loss of Stromal Caveolin-1 Remodel the Tumor Microenvironment by Activating Src-Mediated PEAK1 and PI3K Pathways? Grant $124,050.00
W81XWH-15-1-0473
 U.S. Army Medical Research and Materiel Command
2007/01/01 - 2013/07/31 Lipid raft-mediated apoptosis by death receptors in multiple myeloma and leukemic cells
SFRH / BD / 36254 / 2007
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Dambal, Shweta; Alfaqih, Mahmoud; Sanders, Sergio; Maravilla, Erick; Ramirez-Torres, Adela; Galvan, Gloria C.; Reis-Sobreiro, Mariana; et al. "27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells". Molecular Cancer Research (2020): http://dx.doi.org/10.1158/1541-7786.mcr-19-0974.
    Published • 10.1158/1541-7786.mcr-19-0974
  2. Gill, Navjot Kaur; Ly, Chau; Nyberg, Kendra D.; Lee, Linus; Qi, Dongping; Tofig, Bobby; Reis-Sobreiro, Mariana; et al. "A scalable filtration method for high throughput screening based on cell deformability". Lab on a Chip 19 2 (2019): 343-357. http://dx.doi.org/10.1039/c8lc00922h.
    10.1039/c8lc00922h
  3. Rotinen, Mirja; You, Sungyong; Yang, Julie; Coetzee, Simon G.; Reis-Sobreiro, Mariana; Huang, Wen-Chin; Huang, Fangjin; et al. "ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis". Nature Medicine 24 12 (2018): 1887-1898. https://pubmed.ncbi.nlm.nih.gov/30478421/?from_term=reis+sobreiro+m&from_pos=1.
    Published • 10.1038/s41591-018-0241-1
  4. Reis-Sobreiro, Mariana (D111-9AA5-1E27). "Emerin deregulation links nuclear shape instability to metastatic potential". Cancer Research (2018): http://cancerres.aacrjournals.org/content/early/2018/08/28/0008-5472.CAN-18-0608.
  5. Minciacchi VR; Spinelli C; Reis-Sobreiro M; Cavallini L; You S; Zandian M; Li X; et al. "MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer.". Cancer research (2017): http://europepmc.org/abstract/med/28202510.
    10.1158/0008-5472.can-16-2942
  6. Ciardiello C; Cavallini L; Spinelli C; Yang J; Reis-Sobreiro M; de Candia P; Minciacchi VR; Di Vizio D. "Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.". International journal of molecular sciences (2016): http://europepmc.org/abstract/med/26861306.
    10.3390/ijms17020175
  7. Minciacchi VR; You S; Spinelli C; Morley S; Zandian M; Aspuria PJ; Cavallini L; et al. "Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles.". Oncotarget (2015): http://europepmc.org/abstract/med/25857301.
    10.18632/oncotarget.3598
  8. Sánchez-Blanco A; Rodríguez-Matellán AG; Reis-Sobreiro M; Sáenz-Narciso B; Cabello J; Mohler WA; Mollinedo F. "Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.". Cell cycle (Georgetown, Tex.) (2014): http://europepmc.org/abstract/med/25485582.
    10.4161/15384101.2014.952183
  9. Reis-Sobreiro M; Roué G; Moros A; Gajate C; de la Iglesia-Vicente J; Colomer D; Mollinedo F. "Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma.". Blood cancer journal (2013): http://europepmc.org/abstract/med/23727661.
    10.1038/bcj.2013.15
  10. Reis-Sobreiro M; Gajate C; Mollinedo F. "Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.". Oncogene (2009): http://europepmc.org/abstract/med/19561642.
    10.1038/onc.2009.183
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/12/12 Nuclear shape instability and cancer metastasis XII internal lectures CICS-UBI
University of Beira Interior (Covilhã, Portugal)
2017/05/20 Amoeboid cancer cells shed extracellular vesicles enriched with nuclear derived material Annual meeting of the International Society of Extracellular Vesicles (ISEV)
International Society of Extracellular Vesicles (Toronto, Canada)
2016/05/06 Disruption of the LINC complex in cancer cells drives the genesis of extracellular vesicles with nuclear content. Annual meeting of the International Society of Extracellular Vesicles (ISEV)
The International Society of Extracellular Vesicles (ISEV) (Rotterdam, Netherlands)
2011/04/01 Raft-modulation of PI3K/Akt pathway by antitumor lipids. 4th Spanish Thematic Network of Cooperative Cancer Research Meeting
Institute of Molecular and Cellular Biology of Cancer, Spanish National Research Council (Salamanca, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Elucidar a diversidade fenotípica e funcional das células mielóides em circulação no sangue de doentes de cancro da mama em neoadjuvância
Co-supervisor
 Immunology and Immuno-Oncology (Master)
Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/04/02 - 2020/04/04 Characterisation of macrophages with anti-tumour functions in vivo.
Conference
 Tumor microenvironment
European Association For Cancer Research, United Kingdom

American Association for Cancer Research, United States
2019/05/16 - 2019/05/18 Characterization of macrophages with anti-tumour functions in vitro and in vivo (Poster)
Conference
 5th International Conference of Translational Medicine on Pathogenesis and Therapy of Immunomediated Diseases
Italian Society of Clinical Immunology and Allergology, Italy
2019/04/27 - 2019/04/29 5th Workshop on Dendritic Cells Biology: Anti-tumoral Immunotherapy, from Biology to the Clinic
Workshop
 5th Workshop on Dendritic Cells Biology: Anti-tumoral Immunotherapy, from Biology to the Clinic
Institut Curie, France
2018/11/08 - 2018/11/11 Emerin deregulation links nuclear shape instability to metastatic potential (poster)
Conference
 Society for Basic Urologic Research (SBUR) Annual meeting
Society for Basic Urologic Research (SBUR), United States
2018/06/03 - 2018/06/04 Nuclear shape instability promotes metastasis through loss or mislocalization of emerin (Poster)
Conference
 Cedars-Sinai Research Day IX
Cedars-Sinai Medical Center, United States
2010/09/11 - 2010/09/15 Antimyeloma action of resveratrol by coclustering of death receptors in lipid rafts (Poster)
Conference
 1st International European Molecular Biology Organization (EMBO) conference series, Cellular Signaling & Molecular Medicine
EMBO- European Molecular Biology Organization, Germany
2009/09/23 - 2009/09/26 Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol antimyeloma and antileukemia actions. (Poster)
Conference
 17th European Cell Death Organization (ECDO), Euroconference on Apoptosis. Destruction, Degradation and Cell death control in cancer and neurodegeneration,
Institut Pasteur, France

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/05/08 Approaching the epigenome of triple negative breast cancer to identify new biomarkers
(Thesis) Arguer
 Saioa Mendaza Lainez (PhD)
Universidad de Navarra, Spain
2019/12/16 Prostate cancer cells metabolism on the interplay of androgenic regulation and metabolic environment
(Thesis) Arguer
 Dr. Henrique Cardoso (PhD)
Universidade da Beira Interior, Portugal

Association member

Society Organization name Role
2019 - Current Sociedade Portuguesa de Imunologia(SPI) Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/05 - 2018/05 Lecture "Nuclear shape instability and cancer motility" as part of the discipline of Cell Biophysics in Physiology and Disease (Graduado) UCLA Department of Integrative Biology and Physiology, United States
2017/05 - 2017/05 Lecture "Nuclear shape instability and cancer metastasis" as part of the discipline of Cell Biophysics in Physiology and Disease (Graduado) UCLA Department of Integrative Biology and Physiology, United States
2016/05 - 2016/05 Lecture “Amoeboid motility and cancer metastasis” as part of the discipline of Cell Biophysics in Physiology and Disease (Graduado) UCLA Department of Integrative Biology and Physiology, United States
2012 - 2012 Lecture “Cell Cycle Analysis by Flow Cytometry” Clinical and Biology of Cancer (Master) Universidad de Salamanca, Spain

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Clinical and Translational Medicine
Distinctions

Award

2019 Travel Award (500Euros) to support presentation at International conference
Italian Society of Clinical Immunology and Allergology, Italy