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Helena Nunes Cabaço is a Senior Post-Doctoral Researcher at Gulbenkian Institute for Molecular Medicine (GIMM). She graduated in Biochemistry at the Faculty of Sciences of the University of Lisbon in 2002 and earned her Ph.D. in Biomedical Sciences from the Faculty of Medicine of the University of Lisbon in 2010. Her doctoral research, developed at the Human Immunodeficiency and Immune Reconstitution Lab at the Institute of Molecular Medicine (iMM), focused on Immunology and Human T cell development, particularly on the development of regulatory T cells in the human thymus, earning her the Basic Research Award from NEDAI (Núcleo de Estudos de Doenças Auto-Imunes) of the Portuguese Society of Internal Medicine. In 2015, as a Post-Doc at iMM, she led a project funded by the Gilead Genesis Program, exploring the impact of HIV-2 infection on human T cell development. In 2017 she assumed the role of Senior Post-Doctoral Researcher at the Prudêncio Lab (Plasmodium Infection & Anti-malarial Interventions) at iMM, where she played a pivotal role in evaluating the immune responses during the clinical trial of a novel malaria vaccine candidate, PbVac. This work earned the prestigious 2020 Pfizer Award in Clinical Investigation. Helena Nunes Cabaço has an extensive academic background, having conducted research in Immunology and Neurosciences at renowned institutions worldwide, including the Mayo Clinic (Minnesota, USA), Universidad Miguel Hernandez (Alicante, Spain), Instituto Gulbenkian de Ciência (Lisbon, Portugal), Baylor College of Medicine (Texas, USA), and Erasmus MC University (Rotterdam, The Netherlands). Throughout her career, she has made significant contributions to scientific literature, with numerous peer-reviewed articles, many of which she authored as first author, appearing in reputable journals, including Science Translational Medicine. Helena Nunes Cabaço holds the positions of Assistant Professor at Universidade Lusófona de Humanidades e Tecnologias, where she is the regent teacher of the Immunology class for the Biology and Biochemistry courses, and of Invited Assistant Professor at the Faculty of Medicine of the University of Lisbon. She has further demonstrated her commitment to education by supervising numerous BSc and MSc students and serving on the jury for MSc and Ph.D. theses. She also contributed to the Thesis Committee of students from the Lisbon BioMed PhD Program. Helena Nunes Cabaço has also been involved in organizing various Meetings and Events in the field of Immunology, along with society-oriented initiatives such as the Open International Immunology Day and workshops for children in elementary schools focusing on Vaccines and Science. In 2017, she received an Entrepreneurship award from Healthcare City. In 2020, she organized and coordinated a Task Force at iMM for establishing a Biobank collection of samples from COVID-19 patients. Her current research at GIMM focuses on developing effective malaria vaccines and enhancing vaccine immunogenicity in aging populations, with a strong emphasis on translational potential for future clinical applications.
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Identification

Personal identification

Full name
Helena Isabel Marques Nunes Cabaço

Citation names

  • Cabaço, Helena
  • Nunes-Cabaço, Helena
  • Nunes Cabaço, Helena

Author identifiers

Ciência ID
D01D-34B6-6C79
ORCID iD
0000-0001-7213-2879

Email addresses

  • helena.cabaco@gimm.pt (Professional)
  • hcabaco@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • 217999411 Ext.: 47149 (Professional)

Addresses

  • Instituto de Medicina Molecular. Edifício Egas Moniz, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Parasitology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2010/11/19
Concluded
 Biomedical Sciences (Doutoramento)
Major in Scpeciality: Biopathological Sciences
Universidade de Lisboa Faculdade de Medicina, Portugal
"Development of Regulatory T Cells in the Human Thymus: One Step Beyond" (THESIS/DISSERTATION)
 Honor and Distinction
2002/10/18
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"¿CD39 Expression and B Cell Differentiation; at Transplantation Biology Unit, Mayo Clinic, Rochester, Minnesota, USA ¿ " (THESIS/DISSERTATION)
 17.2/20
Affiliation

Science

Category
Host institution 		Employer
2024/08/01 - Current Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2018/08/01 - 2024/07/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2017/09/01 - 2018/07/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
Erasmus MC, Netherlands
(...)
2011/04/01 - 2017/08/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2020 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Others

Category
Host institution 		Employer
2005/12/01 - 2010/11/19 PhD Student Instituto de Medicina Molecular, Portugal
2002/09/01 - 2004/12/31 Research Fellow Instituto Gulbenkian de Ciência, Portugal
2004/01/01 - 2004/03/31 Research Fellow Universidad Miguel Hernández de Elche, Spain
2003/08/01 - 2003/10/01 Research Fellow Baylor College of Medicine, United States
2003/01/01 - 2003/03/31 Research Fellow Universidad Miguel Hernández de Elche, Spain
2001/10/01 - 2002/09/30 Undergraduate research student Mayo Clinic Minnesota, United States
Projects

Grant

Designation Funders
2021/11/01 - 2024/10/31 Whole-organism vaccines against P. falciparum and P. vivax malaria with enhanced efficacy and scope
HR21-848
Researcher
Caixa d'Estalvis i Pensions de Barcelona, Spain
 Caixa d'Estalvis i Pensions de Barcelona
Ongoing
2022/01/01 - 2023/12/31 X-Chromosome Inactivation in Systemic Lupus Erythematosus
EXPL/MED-OUT/1517/2021
Researcher
Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2011/04/01 - 2017/08/31 IMPACT OF HIV-2 INFECTION ON HUMAN THYMIC FUNCTION
SFRH/BPD/73262/2010
Post-doc
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 Preservation of human thymic T cell production mediated by host restriction factors during HIV infection
PGG/009/2015
Principal investigator
Gilead Sciences Lda
Concluded
2003/11/01 - 2008/02/29 FACTORS IMPACTING ON THYMIC T-CELL DEVELOPMENT
SFRH/BD/12617/2003
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute of Molecular Medicine João Lobo Antunes
LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Projecto Estratégico - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2013 Cellular and molecular requirements for human regulatory T cell development and differentiation
PTDC/SAU-MII/101245/2008
PTDC/SAU-IMU/113541/2009
Post-doc
Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/03/01 - 2012/11/30 Lymphoid tissues in HIV-2 infected patients
PIC/IC/82712/2007
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/11/01 - 2011/04/30 HIV-2 infection and thymus
PTDC/SAU-MII/66248/2006
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/06/01 - 2007/12/31 T cell production in HIV immunodeficiency
POCI/SAU-MMO/60333/2004
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Nunes-Cabaço, Helena. "INATIVAÇÃO DO CROMOSSOMA X NO LÚPUS ERITEMATOSO SISTÉMICO (Oral communication by Patricia Costa Reis)". Paper presented in 24º Congresso Nacional de Pediatria, Vilamoura, 2024.
Conference poster
  1. Nunes-Cabaço, Helena. "INATIVAÇÃO DO CROMOSSOMA X NO LÚPUS ERITEMATOSO SISTÉMICO". Paper presented in 2º Congresso Nacional de Reumatologia Pediátrica, 2024.
  2. Raposo, AASF; Rosmaninho, Pedro; PAÇO, SUSANA; Ângelo-Dias, M; Godinho-Santos, Ana; Nunes-Cabaço, Helena; Tokunaga-Mizoro, Yumie; et al. "Differential Binding in human thymic regulatory T cells refine whole-genome analyses of complex immune diseases". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  3. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Prudêncio M; "Age-dependent Impact of Malaria on Thymic Function"". Paper presented in British Society for Immunology Congress 2022, Liverpool, UK, 2022.
  4. Adriana Temporão; Margarida Sanches-Vaz; Luís, Rafael; Nunes-Cabaço, Helena; Smith TK; Prudêncio, Miguel; Figueiredo, Luisa M.. "Can Trypanosoma brucei be a new ally in the fight against malaria?". Paper presented in 32nd Molecular Parasitology Meeting, 2021.
  5. Nunes-Cabaço, Helena. "Nunes-Cabaco H, Moita D, Rôla C, Mendes AM, Prudêncio M; "Impact of protein deficiency on the immunogenicity and efficacy of malaria vaccination"". Paper presented in EMBL Conference: BioMalPar XVII: Biology and Pathology of the Malaria Parasite, 2021.
  6. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Moita D, Rôla C, Mendes AM, Prudêncio M; "Impact of protein deficiency on the immunogenicity and efficacy of malaria vaccination"". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2021.
  7. Maia, Teresa G.; Duarte, Miguel; Moita, Diana; Nunes-Cabaço, Helena; Mendes, António M.; Prudêncio, Miguel. "New malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites". Paper presented in SPI XLV Meeting, Sociedade Portuguesa de Imunologia, 2019.
  8. Nunes-Cabaço, Helena. "Cunha-Barreto A, Mendes AM, Nunes-Cabaço H, Prudêncio M; "Evaluation of tissue-associated cellular immune responses to PbVAC, a P. berghei-based whole-sporozoite malaria vaccine candidate, in rhesus macaques"". Paper presented in XLV Annual Meeting of the Portuguese Society for Immunology, Coimbra, Portugal, 2019.
  9. Moita, Diana; Meireles, Patrícia; Nunes-Cabaço, Helena; G. Maia, Teresa; M. Mendes, António; Prudêncio, Miguel. "New insights into interferon-mediated immune responses elicited by Plasmodium liver stage infection". Paper presented in XLV Annual Meeting of the Portuguese Society for Immunology, 2019.
  10. Nunes-Cabaço, Helena. "Ramalho-dos-Santos A, Martins L, Caramalho I, Barata J, Sousa AE, Nunes-Cabaço H; "IL-4 induces coreceptor reversal in CD4-committed human thymocytes"". Paper presented in 7th International Kyoto T Cell Conference (KTCC), Kyoto University, Kyoto, Japan, 2017.
  11. Nunes-Cabaço, Helena. "Tokunaga Y, Nunes-Cabaço H, Sousa AE; "Differentiation of FOXP3+ regulatory T cells in the human thymus: unbiased approaches circumventing sequential-gating strategy"". Paper presented in 7th International Kyoto T Cell Conference (KTCC), Kyoto University, Kyoto, Japan, 2017.
  12. Nunes-Cabaço, Helena. "Antão A, Foxall RB, Matoso P, Pires AR, Serra-Caetano A, Sousa AE, Nunes-Cabaço H*, Rocha C*; "In vitro infection of lymphoid tissues by HIV-2"". Paper presented in Portuguese Society for Immunology XLII Annual Meeting, IGC, Lisbon, Portugal, 2016.
  13. Nunes-Cabaço, Helena. "Ramalho-dos-Santos A, Martins L, Caramalho I, Barata J, Sousa AE, Nunes-Cabaço H; "A Role for IL-4 in CD4 T cell Plasticity"". Paper presented in Portuguese Society for Immunology XLII Annual Meeting, IGC, Lisbon, Portugal, 2016.
  14. Nunes-Cabaço, Helena. "Mendes-Passos V, Foxall RB, Matoso P, Pires AR, Tendeiro R, Pinheiro AI, Soares RS, Sousa AE and Nunes-Cabaço H; "Host Restriction Factors OF Retroviral Replication in the Human Thymus"". Paper presented in Portuguese Society for Immunology XLI Annual Meeting, ICVS, Braga, Portugal, 2015.
  15. Nunes-Cabaço, Helena. "Helena Nunes-Cabaço, Vânia Mendes-Passos, Russell B. Foxall, Paula Matoso, Ana R. Pires, Rita Tendeiro, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa; "Host restriction factors of retroviral replication in the human thymus"". Paper presented in 1st International Venice Thymus Meeting 2015, San Servolo Island, Venice, Italy, 2015.
  16. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Matoso P, Foxall RB, Tendeiro R, Pires AR, Pinheiro AI, Soares RS, Sousa AE.; "Infection of the human thymus by HIV-2"". Paper presented in 9th ENII EFIS/EJI Summer School on Advanced Immunology, Porto Conde, Alghero, Sardinia, Italy, 2014.
  17. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Matoso P, Foxall RB, Tendeiro R, Pire AR, Soares RS, Pinheiro AI, Sousa AE; "Infection of the human thymus by HIV-2"". Paper presented in Thymus@Porto II IBMC, Porto, Portugal, 2013.
  18. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Tendeiro R, Foxall RB, Soares RS, Pinheiro AI, Matoso P, Sousa AE; "HIV-2 has a reduced ability to infect the human thymus"". Paper presented in Frontiers in HIV Pathogenesis, Therapy and Eradication Whistler, British Columbia, Canada, 2012.
  19. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Caramalho I, Sepúlveda N, Sousa AE; "Differentiation of human thymic regulatory T-cells at the double positive stage"". Paper presented in Thymus@Porto, IBMC, Porto, Portugal, 2011.
  20. Nunes-Cabaço, Helena. "Nunes-Cabaço H, Ribot JC, Caramalho I, Serra-Caetano A, Silva-Santos B, Sousa AE; "Foxp3 induction in human and murine thymus precedes the CD4+CD8+ stage but requires early TCRalpha expression"". Paper presented in Portuguese Society for Immunology XXXV Annual Meeting, IMM, Lisbon, Portugal, 2009.
  21. Nunes-Cabaço, Helena. "Nunes Cabaço H & Sousa AE; "Dynamics of Foxp3, CD25 and CD127 expression in the human thymus"". Paper presented in World Immune Regulation Meeting – Special Focus on Regulatory Cells, Davos, Switzerland, 2007.
  22. Nunes-Cabaço, Helena. Corresponding author: Nunes-Cabaço, Helena. "Nunes Cabaço H, Haury M, Fairen A, Parra P.; "A Transgenic Mouse Expressing GFP in the Cortical Subplate and Hippocampal Pyramidal Cells at Different Time Points"". Paper presented in FENS (Federation of European Neuroscience Societies) Forum 2004, Lisbon, Portugal, 2004.
  23. Nunes-Cabaço, Helena. "Nunes Cabaço H, Haury M, Fairen A, Parra P.; "A Transgenic Mouse Expressing GFP in the Cortical Subplate and Hippocampal Pyramidal Cells at Different Time Points"". Paper presented in Symposium "New Insights on Developmental Neurobiology", Cadiz, Spain, 2004.
Journal article
  1. Isabella Ramella Gal; Claudia Demarta-Gatsi; Diana Fontinha; Francisca Arez; Sebastian G. Wicha; Matthias Rottmann; Helena Nunes-Cabaço; et al. "Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic Plasmodium berghei". ACS Infectious Diseases (2025): http://dx.doi.org/10.1021/acsinfecdis.4c00563.
    10.1021/acsinfecdis.4c00563
  2. Alexandre A. S. F. Raposo; Pedro Rosmaninho; Susana L. Silva; Susana Paço; Maria E. Brazão; Ana Godinho-Santos; Yumie Tokunaga-Mizoro; et al. "Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells". Frontiers in Immunology (2024): http://dx.doi.org/10.3389/fimmu.2024.1458581.
    10.3389/fimmu.2024.1458581
  3. Fraga, Ana; Mósca, Andreia F.; Moita, Diana; Simas, J. Pedro; Nunes-Cabaço, Helena; Prudêncio, Miguel. "SARS-CoV-2 decreases malaria severity in co-infected rodent models". Frontiers in Cellular and Infection Microbiology 13 (2023): http://dx.doi.org/10.3389/fcimb.2023.1307553.
    10.3389/fcimb.2023.1307553
  4. Moita, Diana; Nunes-Cabaço, Helena; Rôla, Catarina; Franke-Fayard, Blandine; Janse, Chris J.; Mendes, António M.; Prudêncio, Miguel. "Variable long-term protection by radiation-, chemo-, and genetically-attenuated Plasmodium berghei sporozoite vaccines". Vaccine 41 51 (2023): 7618-7625. http://dx.doi.org/10.1016/j.vaccine.2023.11.023.
    10.1016/j.vaccine.2023.11.023
  5. Moita, Diana; Rôla, Catarina; Nunes-Cabaço, Helena; Nogueira, Gonçalo; Maia, Teresa G.; Othman, Ahmad Syibli; Franke-Fayard, Blandine; et al. "The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria". npj Vaccines 8 1 (2023): http://dx.doi.org/10.1038/s41541-023-00778-9.
    10.1038/s41541-023-00778-9
  6. Helena Nunes-Cabaço; Diana Moita; Miguel Prudêncio. "Five decades of clinical assessment of whole-sporozoite malaria vaccines". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.977472.
    10.3389/fimmu.2022.977472
  7. Nunes-Cabaço, Helena; Ramalho-dos-Santos, Andreia; Pires, Ana R.; Martins, Leila R.; Barata, João T.; Sousa, Ana E.. "Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834033.
    Open access • 10.3389/fimmu.2022.834033
  8. Passos, Vânia; Pires, Ana R.; Foxall, Russell B.; Nunes-Cabaço, Helena; Sousa, Ana E.. "Expression of Human Endogenous Retroviruses in the Human Thymus Along T Cell Development". Frontiers in Virology 2 (2022): http://dx.doi.org/10.3389/fviro.2022.826393.
    Open access • Published • 10.3389/fviro.2022.826393
  9. Helena Nunes-Cabaço; Diana Moita; Catarina Rôla; António M. Mendes; Miguel Prudêncio. Corresponding author: Helena Nunes-Cabaço. "Impact of dietary protein restriction on the immunogenicity and efficacy of whole-sporozoite malaria vaccination". (2022):
    Under revision
  10. Adriana Temporão; Katerina Artavanis-Tsakonas; Margarida Sanches-Vaz; Rafael Luís; Helena Nunes-Cabaço; Terry K. Smith; Miguel Prudêncio; Luisa M. Figueiredo. "Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection". PLOS Neglected Tropical Diseases 15 10 (2021): e0009912-e0009912. https://doi.org/10.1371/journal.pntd.0009912.
    Open access • Published • 10.1371/journal.pntd.0009912
  11. Moita, Diana; Nunes-Cabaço, Helena; Mendes, António M.; Prudêncio, Miguel. "A guide to investigating immune responses elicited by whole-sporozoite pre-erythrocytic vaccines against malaria". The FEBS Journal (2021): http://dx.doi.org/10.1111/febs.16016.
    Published • 10.1111/febs.16016
  12. Figueiredo-Campos, Patrícia; Blankenhaus, Birte; Mota, Catarina; Gomes, Andreia; Serrano, Marta; Ariotti, Silvia; Costa, Catarina; et al. "Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset". European Journal of Immunology 50 12 (2020): 2025-2040. http://dx.doi.org/10.1002/eji.202048970.
    Open access • Published • 10.1002/eji.202048970
  13. Reuling, Isaie J.; Mendes, António M.; de Jong, Gerdie M.; Fabra-García, Amanda; Nunes-Cabaço, Helena; van Gemert, Geert-Jan; Graumans, Wouter; et al. "An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria". Science Translational Medicine 12 544 (2020): http://dx.doi.org/10.1126/scitranslmed.aay2578.
    Published • 10.1126/scitranslmed.aay2578
  14. Margarida Sanches-Vaz; Christian R. Engwerda; Adriana Temporão; Rafael Luis; Helena Nunes-Cabaço; António M. Mendes; Sarah Goellner; et al. "Trypanosoma brucei infection protects mice against malaria". PLOS Pathogens 15 11 (2019): e1008145-e1008145. https://doi.org/10.1371/journal.ppat.1008145.
    Open access • Published • 10.1371/journal.ppat.1008145
  15. Fernandes, S M; Pires, A R; Matoso, P; Ferreira, C; Nunes-Cabaço, H; Correia, L; Valadas, E; et al. "HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication". Mucosal Immunology 11 1 (2017): 236-248. http://dx.doi.org/10.1038/mi.2017.44.
    Published • 10.1038/mi.2017.44
  16. Caramalho, Íris; Nunes-Cabaço, Helena; Foxall, Russell B.; Sousa, Ana E.. "Regulatory T-Cell Development in the Human Thymus". Frontiers in Immunology 6 (2015): http://dx.doi.org/10.3389/fimmu.2015.00395.
    Open access • Published • 10.3389/fimmu.2015.00395
  17. Caramalho, Iris; Nunes-Silva, Vânia; Pires, Ana R.; Mota, Catarina; Pinto, Ana I.; Nunes-Cabaço, Helena; Foxall, Russell B.; Sousa, Ana E.. "Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus". Journal of Autoimmunity 56 (2015): 98-110. http://dx.doi.org/10.1016/j.jaut.2014.11.002.
    Published • 10.1016/j.jaut.2014.11.002
  18. Nunes-Cabaço H; Matoso P; Foxall RB; Tendeiro R; Pires AR; Carvalho T; Pinheiro AI; Soares RS; Sousa AE. Corresponding author: Nunes-Cabaço H. "Thymic HIV-2 infection uncovers post-transcriptional control of viral replication in human thymocytes.". (2014): http://europepmc.org/abstract/med/25473058.
    Open access • Published • 10.1128/JVI.03047-14
  19. Nunes-Cabaço, H.; Sousa, A.E.. "Repairing thymic function". Current Opinion in Organ Transplantation 18 3 (2013): 363-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879908506&partnerID=MN8TOARS.
    Open access • Published • 10.1097/MOT.0b013e3283615df9
  20. Nunes-Cabaço, H.; Caramalho, I.; Sepúlveda, N.; Sousa, A.E.. "Differentiation of human thymic regulatory T cells at the double positive stage". European Journal of Immunology 41 12 (2011): 3604-3614. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255164181&partnerID=MN8TOARS.
    Open access • Published • 10.1002/eji.201141614
  21. Fabre-Mersseman, V.; Dutrieux, J.; Louise, A.; Rozlan, S.; Lamine, A.; Parker, R.; Rancez, M.; et al. "CD4+ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis". AIDS 25 9 (2011): 1153-1162. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957667532&partnerID=MN8TOARS.
    Published • 10.1097/QAD.0b013e3283471e89
  22. Nunes-Cabaço, H.; Ribot, J.C.; Caramalho, I.; Serra-Caetano, A.; Silva-Santos, B.; Sousa, A.E.. "Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression". Immunology and Cell Biology 88 5 (2010): 523-528. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954313701&partnerID=MN8TOARS.
    Published • 10.1038/icb.2010.4
Preprint
  1. Raposo, AASF; Rosmaninho, Pedro; Susana Lopes-da-Silva; Paço, Susana; Brazão, Maria E.; Godinho-Santos, Ana; Tokunaga-Mizoro, Yumie; et al. Corresponding author: Raposo, AASF. "Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells". 2023. http://dx.doi.org/10.1101/2023.12.27.573411.
    10.1101/2023.12.27.573411
Thesis / Dissertation
  1. Cabaço, Helena Isabel Marques Nunes, 1979-. "Development of regulatory T cells in the human thymus : one step beyond; Desenvolvimento de células T reguladoras no timo humano". PhD, Universidade de Lisboa Faculdade de Medicina, 2010. http://hdl.handle.net/10451/2277.
  2. "CD39 Expression and B Cell Differentiation". Degree, Mayo Clinic Rochester, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015 Role of IL-4 in the lineage plasticity of human CD4 single positive thymocytes Portuguese Society for Immunology XLI Annual Meeting
ICVS (Braga, Portugal)
2014/04 Targeting T cells at the origin: HIV-2 infection of the human thymus HIV-2: the forgotten virus
Instituto de Medicina Molecular (Lisboa, Portugal)
2011/11 HIV-2 has a reduced ability to infect the human thymus Portuguese Society for Immunology XXXVII Annual Meeting
(Lisboa, Portugal)
2008/11 Foxp3 is expressed in human and mouse pre-DP thymocytes but requires TCRalpha ThymUS 2008 International Conference
(San Juan, Puerto Rico)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - Current Impact of host-associated factors on the immunogenicity and efficacy of malaria vaccination.
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/09/01 - Current Impact of host-associated factors on the immunogenicity and efficacy of malaria vaccination
Supervisor
 Molecular Biology and Genetics (Master)
Gulbenkian Institute for Molecular Medicine, Portugal
2024/02/01 - 2024/06/10 Impact of age on liver infection by the malaria-causing parasite Plasmodium berghei in murine models
Supervisor
 Biology (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2024/03 - 2024/06 Generation of in vitro model to evaluate HIV reactivation and viral reservoirs elimination
Co-supervisor
 Biology (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2024/02 - 2024/06 Analysis of the evolution of low-density neutrophil (LDN) populations in psoriasis patients treated with therapeutic antibodies
Co-supervisor
 Biology (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2022/03 - 2022/06 Immunohistochemical evaluation of the tissue-associated immune response to Plasmodium berghei infection in mice
Supervisor
 Biochemistry (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2021/03 - 2021/06 Characterization of the immune response to Plasmodium infection in murine models
Supervisor
 Biology (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2020/02 - 2020/06 Optimization of 3D visualization methodologies of the pre-erythrocytic immune response in murine models of malaria for application in vaccine development
Supervisor
 Biologia (Degree)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2018/09 - 2019/12 Evaluation of tissue-associated cellular immune responses to PbVAC, a P. berghei-based whole-sporozoite malaria vaccine candidate, in rhesus macaques
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/09 - 2016/09 In vitro infection of lymphoid tissues by HIV-2
Supervisor of Ana Antão
 Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/09 - 2016/09 Role of IL-4 in the lineage plasticity of human CD4 single positive thymocytes
Supervisor of Andreia Ramalho dos Santos
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/09 - 2015/09 Expression and regulation of human endogenous retroviruses in developing and mature T cells
Supervisor of Vânia Mendes Passos
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/03 - 2014/06 Quantification of human endogenous retroviruses in the human thymus
Supervisor
 Biologia Molecular e Genética (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/01 - 2014/02 Expression and modulation of APOBEC3G in human thymocytes
Supervisor of Tânia Carvalho
 Medicina (Other)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/11/15 - Current Lisbon Area Post-Doc (LAPD) Meeting (2018/11/15)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2015/10/16 - Current LIIM (Lisbon Immunology and Infection Meeting) (2015/10/16)
Conference (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2015/06/12 - Current Thymus@Lisbon (2015/06/12)
Conference (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2020/03 - 2020/07 Coordinator of a Task Force of volunteers for the creation of a Biobank collection of samples from patients with COVID-19 (2020/03 - 2020/07)
Other (Other)
 Instituto de Medicina Molecular, Portugal
2019/04/29 - 2019/04/29 International Immunology Day (2019/04/29)
Workshop (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2006 - 2011 Development and elaboration of museological content for Museums and Interpretation Centers in the Islands of Azores, Portugal (2006 - 2011)
Other (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/06/27 - Current Speaker at the Round Table "How to be a good scientist", 4th Chem & Biochem Students Meeting, FCUL
Meeting
 4th Chem & Biochem Students Meeting
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2014 - Current Ciência na Escola: levar a ciência a crianças do 1º ciclo (Science in School: Science for 1st grade Kids)
Workshop
2023/01/19 - 2024/02/10 Pedagogical Training for Teachers of the University of Lisbon: Collaborative Learning with Jigsaw; Filling in the Curriculum Unit Form: Good practices; Challenge-based Learning and Design Thinking; Creating Slides in Microsoft PowerPoint: Procedures and Tips; Moodle Workshop (Beginner, Intermediate and Advanced Level); Breathing and Manifestation of Voice and Speech; The Power of Continuous Assessment; 1st Class of the Semester; Active Methodologies; ChatGPT & Active Learning; Teaching and Learning with Digital; Gamification in the Classroom
Other
 1s Edition of Pedagogical Training for Teachers
Universidade de Lisboa, Portugal
2022/06/07 - 2022/06/08 COLife workshop: intro to light sheet imaging
Workshop
 COLife workshop: intro to light sheet imaging
Instituto de Medicina Molecular, Portugal
2019/11/20 - 2019/11/24 68th Annual ASTMH Meeting Washington, DC, USA
Congress
 68th Annual ASTMH Meeting
American Society of Tropical Medicine and Hygiene, United States
2019/01/24 - 2019/01/25 Horizon 2020 Entrepreneurship for Researchers Workshop iMM-JLA, Lisbon, Portugal
Workshop
 Horizon 2020 Entrepreneurship for Researchers Workshop
2018/10/28 - 2018/11/01 67th Annual ASTMH Meeting New Orleans, LA, USA
Congress
 67th Annual ASTMH Meeting
American Society of Tropical Medicine and Hygiene, United States
2017/10/30 - 2017/10/31 Workshop on Malaria transmission: current challenges and new tools in the elimination context; IHMT, Lisbon, Portugal
Workshop
 Workshop on Malaria transmission: current challenges and new tools in the elimination context
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/12/12 - 2016/12/16 IB16S (Introductory Bioinformatics Course) GTPB, Instituto Gulbenkian de Ciência, Oeiras, Portugal
Workshop
 IB16S (Introductory Bioinformatics Course)
Instituto Gulbenkian de Ciência, Portugal
2016/09/15 - 2016/10/03 Intensive Course in Criminology, CRIAP Institute, Lisbon
Workshop
 Intensive Course in Criminology, CRIAP Institute, Lisbon
2016/06/20 - 2016/06/22 Leadership and Management Skills Course for Postdocs EMBO Lab Management Course (by hfp consulting); iMM-JLA, Lisbon, Portugal
Other
 Leadership and Management Skills Course for Postdocs
2016/04/19 - 2016/05/06 Laboratory Animal Science (FELASA Cat. B; with DGAV license), CAML Advanced Course, iMM-JLA, Lisbon, Portugal
Other
 Laboratory Animal Science (FELASA Cat. B; with DGAV license);
Instituto de Medicina Molecular, Portugal
2015/07/10 - 2015/07/10 Global Health and Tropical Medicine Meeting: HIV Challenges; Instituto de Higiene e Medicina Tropical, Lisbon, Portugal
Meeting
 Global Health and Tropical Medicine Meeting: HIV Challenges
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/06/25 - 2013/06/25 A Nobel Day in Lisbon, Culturgest, Lisbon, Portugal
Conference
 A Nobel Day in Lisbon, Culturgest, Lisbon, Portugal
2012/09/26 - 2012/10/27 Applied Biostatistics Course
Other
 Applied Biostatistics Course
Universidade de Lisboa Faculdade de Medicina, Portugal
2010/10/27 - 2010/10/28 Biosafety Level 3 Facility Course
Other
 Biosafety Level 3 Facility Course
Instituto de Medicina Molecular, Portugal
2006/11/10 - 2006/11/11 Forensic Pathology - from Sample Collection to Expert Diagnosis; 5th National Congress of Legal Medicine, Ericeira, Portugal
Congress
 Forensic Pathology - from Sample Collection to Expert Diagnosis; 5th National Congress of Legal Medicine, Ericeira, Portugal
2006/09/06 - 2006/09/09 1st Joint Meeting of European National Societies of Immunology, Paris, France
Meeting
 1st Joint Meeting of European National Societies of Immunology, Paris, France
2005/02/15 - 2005/02/15 Project Management Course
Workshop
 Project Management Course
Universidade de Lisboa Faculdade de Medicina, Portugal
2003/09 - 2003/09 Laboratory Animal Handling, Baylor College of Medicine, Houston, Texas, USA
Workshop
 Laboratory Animal Handling, Baylor College of Medicine, Houston, Texas, USA
Baylor College of Medicine, United States
2003/06/17 - 2003/06/18 Advanced Light Microscopy in Living Cells
Workshop
 Advanced Light Microscopy in Living Cells
Instituto Gulbenkian de Ciência, Portugal
2001/11 - 2001/11 Laboratory Animal Handling, Mayo Clinic, Rochester, Minnesota, USA
Workshop
 Laboratory Animal Handling, Mayo Clinic, Rochester, Minnesota, USA
Mayo Clinic Rochester, United States
2001/11 - 2001/11 Working Safe with Radioactive Materials, Mayo Clinic, Rochester, Minnesota, USA
Workshop
 Working Safe with Radioactive Materials, Mayo Clinic, Rochester, Minnesota, USA
Mayo Clinic Rochester, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/21 “BALTing the Lung lmmune Response”
(Thesis) Main arguer
 Margarida Ferreira Pereira Bobela Kirby (Master)
Universidade Nova de Lisboa Medical School, Portugal
2024/01/08 Designing novel CAR T cells to eliminate latently HIV-1-infected cells
(Thesis) Main arguer
 Tiago Gil (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07/12 HIV infection and Follicular Helper T cells: interrogating the SAMHD1 contribution through HIV-2
(Thesis) Main arguer
 André Gomes Pires (Master)
Instituto de Medicina Molecular, Portugal
2022/02/07 Tissue Resident Memory T cells ontogeny: Unravelling precursor phenotypes in circulation
(Thesis) Main arguer
 Íris da Mota Lima Correia Ramos (Master)
Instituto de Medicina Molecular, Portugal
2021/01/29 The impact of Protein Tyrosine Phosphatases on the activation of intraepithelial lymphocytes
(Thesis) Main arguer
 Joana Gonçalves (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/10/23 Thymic infection and T cell immunodominance during Mycobacterium avium infection
(Thesis) Arguer
 Bruno Rodrigues (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/10 Impact of the immune system aging on multiple sclerosis forms of progression: study of the thymic function
(Thesis) Main arguer
 João Manuel do Canto Gomes (Master)
Universidade do Minho Escola de Medicina, Portugal
2014/01/08 Avaliação da função tímica na reconstituição imunitária de indivíduos infetados pelo vírus da imunodeficiência humana
(Thesis) Main arguer
 Tiago Fernandes (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Association member

Society Organization name Role
2022 - Current British Society for Immunology
2005 - Current Portuguese Society for Immunology

Committee member

Activity description
Role 		Institution / Organization
2023/10/01 - Current PhD Thesis Committee (Tutor) of Margarida Pedro (Lisbon BioMed)
Member
 Gulbenkian Institute for Molecular Medicine, Portugal
2022/02/01 - Current PhD Thesis Committee (Tutor) of Lúcia Serra (Lisbon BioMed)
Member
 Instituto de Medicina Molecular, Portugal
2020 - Current PhD Thesis Committee (Tutor) of Ana Cachucho (Lisbon BioMed)
Member
 Instituto de Medicina Molecular, Portugal
2017 - 2022 PhD Thesis Committee (Tutor) of Henrique Machado (Lisbon BioMed)
Member
 Instituto de Medicina Molecular, Portugal
2018/03 - 2019/02 iMM-JLA Post Doc Association Committee, iMM-JLA, Lisbon, Portugal
Member
 Instituto de Medicina Molecular, Portugal
2017 - 2018 ANICT Board
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09/01 - Current Immunology - Nutrition Sciences Course (Curricular Unit, Theoretical and Theoretical-Practical Classes) Immunology (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal
2024/09/01 - Current Immunology - Masters Integrated in Medicine (Curricular Unit, Theoretical Classes) Masters Integrated in Medicine (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09 - Current Immunology (Curricular Unit, Theoretical and Practical Course) Biologia/Bioquímica Universidade Lusófona de Humanidades e Tecnologias, Portugal
2022/11/24 - 2022/11/24 Pre-clinical and clinical evaluation of a genetically modified rodent malaria parasite for immunization against human malaria MSc in Biochemistry and Biomedicine and MSc in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/26 - 2021/03/26 Malária: etiologia e perspectivas para o controlo por vacinação Molecular Biology and Genetics (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/10/27 - 2020/10/27 Malaria vaccination. Design, characterization and (pre-) clinical evaluation of a new vaccine against malaria Mestrado em Investigação Biomédica (Mestrado) Instituto de Medicina Molecular, Portugal
2020/03/27 - 2020/03/27 Avaliação clínica de um novo candidato a vacinação contra a malária Molecular and Genetic Biology Masters, FCUL, Lisbon, Portugal (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/05/24 - 2019/05/24 Malária: etiologia e perspectivas para o controlo por vacinação Molecular and Genetic Biology Masters, FCUL, Lisbon, Portugal (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/04/03 - 2019/04/03 Malaria vaccination. Design, characterization and (pre-) clinical evaluation of a new vaccine against malaria Biology at the Host Microbe Interface PhD Program (Doutoramento) Instituto de Medicina Molecular, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020/12 - Current Frontiers in Immunology (1664-3224)

Other jury / evaluation

Activity description Institution / Organization
2024/06/20 - Current Jury of the BSc project: "Investigation of the Proviral Reservoir in HIV Infected Patients”, Mariana Campos; Project in Molecular and Cellular Biology Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/30 - 2022/09/30 Jury of: Evaluation of novel anti-plasmodial drug combinations in a 3D model of hepatic infection by Plasmodium falciparum; Isabella Gal; Postgraduate Programme on Research Practice, iBET, Oeiras, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal
2020/05 - 2020/06 Jury of the BSc project: "Validação de inibidores da proteína EZH2 e o seu efeito na reativação do VIH-1" from Bruno Domingos, Biology Course, ULHT Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2020 - 2020/06 Jury of the BSc project: "The importance of methionine metabolism during Plasmodium intra-erythrocytic development", from Ana Sofia Santana Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinctions

Award

2020 Pfizer Award in Clinical Investigation (Science Translational Medicine 2020 Article)
2017 Life Sciences Arena Entrepreneurship Contest - 1st Place
2012 NEDAI Award for Basic Research in Autoimmunity
1998 Top 3 students of the Faculty of Sciences of the University of Lisbon
Universidade de Lisboa Faculdade de Ciências, Portugal

Other distinction

2010 Best SPI Website Image: Honorable Mention
Sociedade Portuguesa de Imunologia, Portugal