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Mireia Castillo-Martin. Completed the Doctorat in La valoració de les alteracions genètiques i de l'immunofenotip millora la detecció i seguiment de les neoplàsies urotelials in 2006/10/25 by Universitat de Barcelona Departament de Biologia Cellular, DEA in Anatomia Patològica in 2003/05/01 by Universitat Autònoma de Barcelona, Postgraduate Certificate in Especialitat en Anatomia Patológica in 2002/05/01 by Atenció Sociosanitària Hospital Clínic and Bachelor in Medicina i Cirurgia in 1994/07/01 by Universitat de Barcelona. Facultat de Medicina. Is Team Leader in the Champalimaud Centre for the Unknown (CCU), Attending pathologist in Centro Clínico Champalimaud, Assistant Professor of Research in Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine and Director of the Champalimaud Foundation Biobank (CFB) in the CCU. Published 89 articles in journals. Has 5 section(s) of books. Has 1 patent(s) registered. Supervised 1 PhD thesis(es). Supervised 3 MSc dissertation(s). Has received 3 awards and/or honors. Participates and/or participated as Principal investigator in 2 project(s) and Researcher in 3 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pathology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: bladder cancer; .
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Identification

Personal identification

Full name
Mireia Castillo-Martin

Citation names

  • Castillo-Martin, Mireia
  • Castillo-Martin M
  • Castillo M

Author identifiers

Ciência ID
CF1A-4E80-8168
ORCID iD
0000-0001-8926-6013

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
Catalan (Mother tongue)
Spanish; Castilian (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2006/10/25
Concluded
 La valoració de les alteracions genètiques i de l'immunofenotip millora la detecció i seguiment de les neoplàsies urotelials (Doctorat)
Universitat de Barcelona Departament de Biologia Cellular, Spain
"Evaluation of the genetic and immunophenotypical alterations improves primary detection and follow-up of urothelial neoplasms. " (THESIS/DISSERTATION)
 Excelente Cum Laude
2003/05/01
Concluded
 Anatomia Patològica (DEA)
Universitat Autònoma de Barcelona, Spain
 n/a
2002/05/01
Concluded
 Especialitat en Anatomia Patológica (Postgraduate Certificate)
Atenció Sociosanitària Hospital Clínic, Spain
"n/a" (THESIS/DISSERTATION)
 n/a
1994/07/01
Concluded
 Llicenciatura en Medicina i Cirurgia (Bachelor)
Universitat de Barcelona. Facultat de Medicina, Spain
"n/a" (THESIS/DISSERTATION)
 n/a
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2019/02/06 - Current Director of the Champalimaud Foundation Biobank (CFB) Centro Champalimaud, Portugal
2015/08/01 - Current Team Leader Centro Champalimaud, Portugal
2015/08/01 - Current Attending pathologist Centro Champalimaud, Portugal
2011/04/11 - Current Assistant Professor of Research Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine, United States
2011/04/11 - 2015/07/31 Co-Director of the Biorepository and Pathology CORE Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine, United States
2009/11/01 - 2011/04/10 Associate Research Scientist Herbert Irving Comprehensive Cancer Center, United States
2006/12/01 - 2009/10/31 Postdoctoral Fellow Herbert Irving Comprehensive Cancer Center, United States
2004/12/01 - 2006/07/31 Attending pathologist Hospital Universitari de Bellvitge, Spain
2003/07/01 - 2004/11/30 Attending pathologist Hospital Clínic de Barcelona, Spain
2002/11/01 - 2003/06/30 Research Fellow Hospital Clínic de Barcelona, Spain
2002/06/01 - 2002/07/31 Attending pathologist Hospital Clínic de Barcelona, Spain

Others

Category
Host institution 		Employer
2002/08/01 - 2002/10/31 Volunteering in the Hospital of Bathalapalli Fundación Vicente Ferrer, India
Projects

Grant

Designation Funders
2023/07/01 - 2026/06/30 Innovative approaches for pancreatic cancer: Decoding and manipulating immune response to short sialylated O-glycans
2022. 04607.PTDC
Co-Principal Investigator (Co-PI)
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/08/01 - 2022/03/31 ROLES AND REGULATION OF P53
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5P01CA087497-04/US
Researcher
Center for Cancer Research
Ongoing
2019/01/01 - 2021/12/31 Eradicating prostate cancer metastasis before clinical manifestation
HR17-00094
Principal investigator
Fundação Champalimaud, Portugal
 Caixa d'Estalvis i Pensions de Barcelona
Ongoing
2017/01/01 - 2019/12/31 Mecanismos epigenéticos de resistencia a la castración en cancer de próstata: oportunidades terapéuticas en combinación con antagonistas del receptor de andrógenos
Ref.: PI16/01070
Researcher
Concluded
2016/05/01 - 2017/04/30 Genomic analysis of primary muscle-invasive bladder cancers and correlation with clinical outcomes
xxx
Researcher
Vasculonox Inc
Concluded
2012/07/01 - 2014/06/30 Role of ¿Np63 isoform in progression from high grade non-muscle invasive to invasive bladder cancer.
xxx
Principal investigator
SASS Foundation
Concluded
Outputs

Publications

Book chapter
  1. Ligeiro, Dário; Rao, Martin; Maia, Andreia; Castillo, Mireia; Beltran, Antonio; Maeurer, Markus. "B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer: Opportunities for Precision Medicine?". In Advances in Experimental Medicine and Biology, 175-195. Springer International Publishing, 2020.
    10.1007/978-3-030-49270-0_10
  2. Carrasco-Avino, Gonzalo; Greenbaum, Benjamin; Castillo-Martin, Mireia; Firpo, Adolfo; Cordon-Cardo, Carlos; Kalir, Tamara. "Genomic Analysis of Epithelial Ovarian Cancer". In Ovarian Cancer-Challenges and Innovations, 130-147. United States: BENTHAM SCIENCE PUBLISHERS, 2019.
    10.2174/9789811421860119010008
  3. Castillo-Martin, Mireia; Ribeiro, Joana. "Case Studies: Molecular Pathology Perspective and Impact on Oncologic Patients’ Management". In Molecular and Cell Biology of Cancer - when cells break the rules and hijack their own planet, 191-216. 2019.
    Published • 10.1007/978-3-030-11812-9_10
  4. Castillo-Martin, Mireia; Thin, Tin Htwe; Lorduy, Ana Collazo; Cordon-Cardo, Carlos. "Immunopathologic Assessment of PTEN Expression". In Methods in Molecular Biology, 23-37. Springer New York, 2015.
    Published • 10.1007/978-1-4939-3299-3_3
  5. Castillo-Martin, Mireia. "El ciclo celular y sus alteraciones en cáncer". In Aplicabilidad de la Biología Molecular en Urología, 46-68. Madrid, Spain, 2005.
    Published
  6. Castillo-Martin, Mireia. "Cistitis glandular". In Patologías excepcionales en urología, 271-293. Madrid, Spain, 2004.
    Published
Conference paper
  1. Lerias, Joana; António, Patrícia; Kamiki, Jéssica; Eduardo, Rodrigo; Cascais, Sara; Marinheiro, Bernardo; Sousa, Eric De; et al. "355 TCR ¿d+ TIL from patients with pancreatic cancer recognize autologous tumor cells restricted by CD1d". 2022.
    10.1136/jitc-2022-sitc2022.0355
  2. Noronha, Pedro; Paraschoudi, Georgia; Sousa, Eric; Kamiki, Jéssica; António, Patrícia; Condenço, Carolina; Silva, Inês; et al. "326 SARS-CoV-2 specific T-cells in TIL from patients with epithelial cancer". 2020.
    10.1136/jitc-2020-sitc2020.0326
  3. Kamiki, Jéssica; António, Patrícia; Noronha, Pedro; Condeço, Carolina; Paraschoudi, Georgia; Sousa, Eric De; Maia, Andreia; et al. "166 Mucosal-associated invariant T-cells (MAIT) in pancreatic cancer". 2020.
    10.1136/jitc-2020-sitc2020.0166
Journal article
  1. Mendes, Raquel V.; Ribeiro, Joana M.; Gouveia, Helena; Rebelo de Almeida, Cátia; Castillo-Martin, Mireia; Brito, Maria José; Canas-Marques, Rita; et al. "Zebrafish Avatar testing preclinical study predicts chemotherapy response in breast cancer". npj Precision Oncology 9 1 (2025): https://doi.org/10.1038/s41698-025-00882-0.
    10.1038/s41698-025-00882-0
  2. Bilreiro, Carlos; Fernandes, Francisca F.; Simões, Rui V.; Henriques, Rafael; Chavarrías, Cristina; Ianus, Andrada; Castillo-Martin, Mireia; et al. "Pancreatic Intraepithelial Neoplasia Revealed by Diffusion-Tensor MRI". Investigative Radiology (2024): https://doi.org/10.1097/rli.0000000000001142.
    10.1097/rli.0000000000001142
  3. Herrando, Alberto Ignacio; Fernandez, Laura M.; Azevedo, José; Vieira, Pedro; Domingos, Hugo; Galzerano, Antonio; Shcheslavskiy, Vladislav; et al. "Detection and characterization of colorectal cancer by autofluorescence lifetime imaging on surgical specimens". Scientific Reports 14 1 (2024): https://doi.org/10.1038/s41598-024-74224-8.
    10.1038/s41598-024-74224-8
  4. Costa, Bruna; Estrada, Marta F.; Gomes, António; Fernandez, Laura M.; Azevedo, José M.; Póvoa, Vanda; Fontes, Márcia; et al. "Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer". Nature Communications 15 1 (2024): https://doi.org/10.1038/s41467-024-49051-0.
    10.1038/s41467-024-49051-0
  5. Herrando, Alberto I.; Castillo-Martin, Mireia; Galzerano, Antonio; Fernández, Laura; Vieira, Pedro; Azevedo, José; Parvaiz, Amjad; et al. "Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues". Biomedical Optics Express 15 6 (2024): 3507. https://doi.org/10.1364/boe.505220.
    10.1364/boe.505220
  6. Andreia Maia; Mubin Tarannum; Joana R. Lérias; Sara Piccinelli; Luis Miguel Borrego; Markus Maeurer; Rizwan Romee; Mireia Castillo-Martin. "Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy". Cells (2024): https://doi.org/10.3390/cells13050451.
    10.3390/cells13050451
  7. • El Sissy C. "Erratum: International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy". Journal of Clinical Oncology 42 7 (2024): 863-863. https://doi.org/10.1200/jco.24.00102.
    10.1200/jco.24.00102
  8. El Sissy, Carine; Kirilovsky, Amos; Lagorce Pagès, Christine; Marliot, Florence; Custers, Petra A.; Dizdarevic, Edina; Sroussi, Marine; et al. "International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy". Journal of Clinical Oncology 42 1 (2024): 70-80. http://dx.doi.org/10.1200/jco.23.00586.
    10.1200/jco.23.00586
  9. Cordeiro, Rodrigo; Morgado, Margarida; Oliveira, Vera; Bispo, Miguel; Castillo-Martin, Mireia; Matos, Celso. "Gastric schwannoma: Two case reports and review of the literature". Radiology Case Reports 18 12 (2023): 4465-4473. http://dx.doi.org/10.1016/j.radcr.2023.09.048.
    10.1016/j.radcr.2023.09.048
  10. Piras, Roberta; Ko, Emily Y.; Barrett, Connor; De Simone, Marco; Lin, Xianzhi; Broz, Marina T.; Tessaro, Fernando H. G.; et al. "circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-34872-8.
    10.1038/s41467-022-34872-8
  11. Treaba, Diana O.; Bonal, Dennis M.; Chorzalska, Anna; Castillo-Martin, Mireia; Oakes, Alissa; Pardo, Makayla; Petersen, Max; et al. "Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles". British Journal of Haematology 200 6 (2022): 740-754. http://dx.doi.org/10.1111/bjh.18513.
    10.1111/bjh.18513
  12. Costa, Bruna; Fernandez, Laura M.; Parés, Oriol; Rio-Tinto, Ricardo; Santiago, Inês; Castillo-Martin, Mireia; Parvaiz, Amjad; Fior, Rita. "Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.862889.
    10.3389/fonc.2022.862889
  13. Abdulghani, Saba; Afonso, Ângela; Castillo, Mireia; Martín-Fernández, Javier; Franco, Inês; Parreira, Bruna; Couto, Ana; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response". Acta Médica Portuguesa 35 6 (2022): 411-415. http://dx.doi.org/10.20344/amp.17856.
    10.20344/amp.17856
  14. Zabala-Letona, Amaia; Arruabarrena-Aristorena, Amaia; Fernandez-Ruiz, Sonia; Viera, Cristina; Carlevaris, Onintza; Ercilla, Amaia; Mendizabal, Isabel; et al. "PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer". Oncogenesis 11 1 (2022): http://dx.doi.org/10.1038/s41389-022-00382-x.
    10.1038/s41389-022-00382-x
  15. Kirilovsky, Amos; Sissy, Carine El; Zeitoun, Guy; Marliot, Florence; Haicheur, Nacilla; Lagorce-Pagès, Christine; Taieb, Julien; et al. "The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life?". Oncotarget 13 1 (2022): 18-31. http://dx.doi.org/10.18632/oncotarget.28100.
    10.18632/oncotarget.28100
  16. Kanagasabai, Thanigaivelan; Li, Guoliang; Shen, Tian Huai; Gladoun, Nataliya; Castillo-Martin, Mireia; Celada, Sherly I.; Xie, Yingqiu; et al. "MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway". Cancer Letters 525 (2022): 46-54. http://dx.doi.org/10.1016/j.canlet.2021.09.041.
    10.1016/j.canlet.2021.09.041
  17. Fernandez, Laura M.; Figueiredo, Nuno; Habr-Gama, Angelita; São Julião, Guilherme P.; Vieira, Pedro; Vailati, Bruna B.; Nasir, Irfan; et al. "cT2N0 Distal Rectal Cancer: Do Not Believe in Fairy Tales". Diseases of the Colon & Rectum 65 1 (2021): e22-e22. http://dx.doi.org/10.1097/dcr.0000000000002307.
    10.1097/dcr.0000000000002307
  18. Flor-de-Lima, Beatriz; S· Freitas, Patrícia; Couto, Nuno; Castillo-Martin, Mireia; Santiago, Inês. "Pancreatic intraductal papillary mucinous neoplasm associated colloid carcinoma". Radiology Case Reports 16 10 (2021): 2989-2992. http://dx.doi.org/10.1016/j.radcr.2021.07.021.
    10.1016/j.radcr.2021.07.021
  19. Tavares Barroso, Mariana; Costa, Bruna; Rebelo de Almeida, Cátia; Castillo Martin, Mireia; Couto, Nuno; Carvalho, Tânia; Fior, Rita. "Establishment of Pancreatobiliary Cancer Zebrafish Avatars for Chemotherapy Screening". Cells 10 8 (2021): 2077. http://dx.doi.org/10.3390/cells10082077.
    Published • 10.3390/cells10082077
  20. Sofia C. Vaz; Mireia Castillo-Martin; Ângelo F. Silva; Joana C. Castanheira; Carla Oliveira; Durval C. Costa. "PSMA expression in thyroid nodule". Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) (2021): https://doi.org/10.1016/j.remnie.2020.04.010.
    10.1016/j.remnie.2020.04.010
  21. de Sousa, Eric; Lérias, Joana R.; Beltran, Antonio; Paraschoudi, Georgia; Condeço, Carolina; Kamiki, Jéssica; António, Patrícia Alexandra; et al. "Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.592031.
    10.3389/fimmu.2021.592031
  22. Fernandez LM; Figueiredo NL; Habr-Gama A; Julião GPS; Vieira P; Vailati BB; Nasir I; et al. "Salvage Surgery after Organ-Preservation - Simply Another Piece of the Puzzle.". Diseases of the colon and rectum (2021): http://europepmc.org/abstract/med/33625053.
    10.1097/dcr.0000000000002003
  23. Fernandez, Laura M.; Figueiredo, Nuno L.; Habr-Gama, Angelita; São Julião, Guilherme P.; Vieira, Pedro; Vailati, • Bruna B.; Nasir, Irfan; et al. "Salvage Surgery With Organ Preservation for Patients With Local Regrowth After Watch and Wait: Is It Still Possible?". Diseases of the Colon & Rectum 63 8 (2020): 1053-1062. http://dx.doi.org/10.1097/dcr.0000000000001707.
    10.1097/dcr.0000000000001707
  24. Castillo-Martin, Mireia; Sofia Carrilho Vaz; Ângelo Silva; Carla Oliveira; Rita Marques; António Galzerano; Mireia Castillo-Martin. "Impact of PSMA PET/CT in prostate cancer patient’s clinical management – a pictorial essay of interesting cases with histologic confirmation". Clinical and Translational Imaging (2020): https://doi.org/10.1007/s40336-020-00372-2.
    Under revision • 10.1007/s40336-020-00372-2
  25. Castillo-Martin, Mireia. "Antagonistic roles of deltaNp63 and AGR2 in progression of Non-Muscle Invasive Bladder Cancer and their potential therapeutic implications". Clinical Cancer Research (2020):
    Submitted
  26. Lérias, Joana R.; Paraschoudi, Georgia; de Sousa, Eric; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies". Frontiers in Cell and Developmental Biology 7 (2020): http://dx.doi.org/10.3389/fcell.2019.00362.
    Published • 10.3389/fcell.2019.00362
  27. Lérias, Joana R.; de Sousa, Eric; Paraschoudi, Georgia; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities". Frontiers in Microbiology 10 (2020): http://dx.doi.org/10.3389/fmicb.2019.02924.
    Published • 10.3389/fmicb.2019.02924
  28. Sousa Félix, Catarina; Chaves Marques, Susana; Bispo, Miguel; Castillo, Mireia; Bana e Costa, Tiago; Chagas, Cristina. "A Pancreatic Cyst Leading to Obstructive Jaundice". GE - Portuguese Journal of Gastroenterology 27 6 (2020): 446-448. http://dx.doi.org/10.1159/000507203.
    10.1159/000507203
  29. Castillo-Martin, Mireia; Gladoun, Nataliya; Han, Dan; Firpo-Betancourt, Adolfo; Silva, Jose M.; Cordon-Cardo, Carlos; Mireia Castillo-Martin; et al. "Transformed bone marrow cells generate neoplasms of distinct histogenesis. a murine model of cancer transplantation". Stem Cell Research 41 (2019): 101637-101637. http://dx.doi.org/10.1016/j.scr.2019.101637.
    Published • 10.1016/j.scr.2019.101637
  30. Nasir, Irfan; Fernandez, Laura; Vieira, Pedro; Parés, Oriol; Santiago, Inês; Castillo-Martin, Mireia; Domingos, Hugo; et al. "Salvage surgery for local regrowths in Watch & Wait - Are we harming our patients by deferring the surgery?". European Journal of Surgical Oncology 45 9 (2019): 1559-1566. http://dx.doi.org/10.1016/j.ejso.2019.04.006.
    10.1016/j.ejso.2019.04.006
  31. Chuang, Ling-shiang; Morrison, Joshua; Hsu, Nai-yun; Labrias, Philippe Ronel; Nayar, Shikha; Chen, Ernie; Villaverde, Nicole; et al. "Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease". Disease Models & Mechanisms 12 8 (2019): dmm037432. http://dx.doi.org/10.1242/dmm.037432.
    Published • 10.1242/dmm.037432
  32. Guarnerio, Jlenia; Zhang, Yang; Cheloni, Giulia; Panella, Riccardo; Mae Katon, Jesse; Simpson, Mark; Matsumoto, Akinobu; et al. "Intragenic antagonistic roles of protein and circRNA in tumorigenesis". Cell Research 29 8 (2019): 628-640. http://dx.doi.org/10.1038/s41422-019-0192-1.
    Published • 10.1038/s41422-019-0192-1
  33. Bispo, Miguel; Rio-Tinto, Ricardo; Fidalgo, Paulo; Castillo-Martin, Mireia; Devière, Jacques. "Late Colon Involvement by Lobular Carcinoma of the Breast: A Diagnosis to Keep in Mind!". GE - Portuguese Journal of Gastroenterology 27 1 (2019): 47-49. http://dx.doi.org/10.1159/000497390.
    Published • 10.1159/000497390
  34. Ming Chen; Jiangwen Zhang; Alice H. Berger; Moussa S. Diolombi; Christopher Ng; Jacqueline Fung; Roderick T. Bronson; et al. "Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis". Journal of Clinical Investigation (2018): https://doi.org/10.1172/JCI99699.
    10.1172/JCI99699
  35. Wang, Li; Saci, Abdel; Szabo, Peter M.; Chasalow, Scott D.; Castillo-Martin, Mireia; Domingo-Domenech, Josep; Siefker-Radtke, Arlene; et al. "EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05992-x.
    10.1038/s41467-018-05992-x
  36. Lee, Eunjee; Collazo-Lorduy, Ana; Castillo-Martin, Mireia; Gong, Yixuan; Wang, Li; Oh, William K.; Galsky, Matthew D.; Cordon-Cardo, Carlos; Zhu, Jun. "Identification of microR-106b as a prognostic biomarker of p53-like bladder cancers by ActMiR". Oncogene 37 44 (2018): 5858-5872. http://dx.doi.org/10.1038/s41388-018-0367-0.
    10.1038/s41388-018-0367-0
  37. Pozo, Eduardo; Castellano, Jose M.; Kanwar, Anubhav; Deochand, Rajiv; Castillo-Martin, Mireia; Pazos-López, Pablo; González-Lengua, Carlos; et al. "Myocardial Amyloid Quantification with Look-Locker Magnetic Resonance Sequence in Cardiac Amyloidosis. Diagnostic Accuracy in Clinical Practice and Histological Validation". Journal of Cardiac Failure 24 2 (2018): 78-86. http://dx.doi.org/10.1016/j.cardfail.2017.08.445.
    Published • 10.1016/j.cardfail.2017.08.445
  38. Martín-Martín, Natalia; Zabala-Letona, Amaia; Fernández-Ruiz, Sonia; Arreal, Leire; Camacho, Laura; Castillo-Martin, Mireia; Cortazar, Ana R.; et al. "PPARd Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth". Cancer Research 78 2 (2018): 399-409. http://dx.doi.org/10.1158/0008-5472.can-17-0908.
    10.1158/0008-5472.can-17-0908
  39. Chen, Ming; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G.; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; et al. "An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer". Nature Genetics 50 2 (2018): 206-218. http://dx.doi.org/10.1038/s41588-017-0027-2.
    10.1038/s41588-017-0027-2
  40. Castillo-Martin, Mireia. "Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst and anomalous pancreaticobiliary junction: case report". BJR Case Rep 4 20180079 (2018):
    Published
  41. Zabala-Letona, Amaia; Arruabarrena-Aristorena, Amaia; Martín-Martín, Natalia; Fernandez-Ruiz, Sonia; Sutherland, James D.; Clasquin, Michelle; Tomas-Cortazar, Julen; et al. "mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer". Nature 547 7661 (2017): 109-113. http://dx.doi.org/10.1038/nature22964.
    10.1038/nature22964
  42. Agrawal, Praveen; Fontanals-Cirera, Barbara; Sokolova, Elena; Jacob, Samson; Vaiana, Christopher A.; Argibay, Diana; Davalos, Veronica; et al. "A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis". Cancer Cell 31 6 (2017): 804-819.e7. http://dx.doi.org/10.1016/j.ccell.2017.05.007.
    10.1016/j.ccell.2017.05.007
  43. Kuchay, Shafi; Giorgi, Carlotta; Simoneschi, Daniele; Pagan, Julia; Missiroli, Sonia; Saraf, Anita; Florens, Laurence; et al. "PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth". Nature 546 7659 (2017): 554-558. http://dx.doi.org/10.1038/nature22965.
    Published • 10.1038/nature22965
  44. Chen, Muhan; Nowak, Dawid G.; Narula, Navneet; Robinson, Brian; Watrud, Kaitlin; Ambrico, Alexandra; Herzka, Tali M.; et al. "The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein". Journal of Cell Biology 216 3 (2017): 641-656. http://dx.doi.org/10.1083/jcb.201604025.
    Published • 10.1083/jcb.201604025
  45. Shukla-Dave, Amita; Castillo-Martin, Mireia; Chen, Ming; Lobo, Jose; Gladoun, Nataliya; Collazo-Lorduy, Ana; Khan, Faisal M.; et al. "Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling". The American Journal of Pathology 186 12 (2016): 3131-3145. http://dx.doi.org/10.1016/j.ajpath.2016.08.021.
    10.1016/j.ajpath.2016.08.021
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    Published • 10.1159/000089416
  105. CASTILLO, MIREIA; PETIT, ANNA; MELLADO, BEGOÑA; PALACÍN, ANTONIO; ALCOVER, JOAN B.; MALLOFRÉ, CARME. "C-KIT EXPRESSION IN SARCOMATOID RENAL CELL CARCINOMA: POTENTIAL THERAPY WITH IMATINIB". Journal of Urology 171 6 Part 1 (2004): 2176-2180. http://dx.doi.org/10.1097/01.ju.0000127727.33232.cf.
    Published • 10.1097/01.ju.0000127727.33232.cf
  106. Alos, L; Castillo, M; Nadal, A; Caballero, M; Mallofre, C; Palacin, A; Cardesa, A. "Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases". Histopathology 44 6 (2004): 570-579. http://dx.doi.org/10.1111/j.1365-2559.2004.01881.x.
    Published • 10.1111/j.1365-2559.2004.01881.x
  107. Petit, Anna; Castillo, Mireia; Santos, Mónica; Mellado, Begoña; Alcover, Joan B; Mallofré, Carme. "KIT Expression in Chromophobe Renal Cell Carcinoma". The American Journal of Surgical Pathology 28 5 (2004): 676-678. http://dx.doi.org/10.1097/00000478-200405000-00017.
    Published • 10.1097/00000478-200405000-00017
  108. Martínez, Antoni; Aymerich, Marta; Castillo, Mireia; Colomer, Dolors; Bellosillo, Beatriz; Campo, Elias; Villamor, Neus. "Routine use of immunophenotype by flow cytometry in tissues with suspected hematological malignancies". Cytometry Part B: Clinical Cytometry 56B 1 (2003): 8-15. http://dx.doi.org/10.1002/cyto.b.10044.
    Published • 10.1002/cyto.b.10044
  109. Mallofré, Carme; Castillo, Mireia; Morente, Vanesa; Solé, Manel. "Immunohistochemical Expression of CK20, p53, and Ki-67 as Objective Markers of Urothelial Dysplasia". Modern Pathology 16 3 (2003): 187-191. http://dx.doi.org/10.1097/01.mp.0000056628.38714.5d.
    Published • 10.1097/01.mp.0000056628.38714.5d
  110. Clarós, Pedro; Dominte, Gabriela; Clarós, Andres; Castillo, Mireia; Cardesa, Antonio. "Parotid gland mucoepidermoid carcinoma in a 4-year-old child". International Journal of Pediatric Otorhinolaryngology 63 1 (2002): 67-72. http://dx.doi.org/10.1016/s0165-5876(01)00637-1.
    Published • 10.1016/s0165-5876(01)00637-1
Translation
  1. Castillo-Martin, Mireia. 7th Edition of Robbins and Cotran Pathologic Basis of Disease. Madrid, Spain: Elsevier Espana. 2005.
    Published

Intellectual property

Patent
  1. Castillo-Martin, Mireia; Cordon-Cardo, Carlos; Domingo-Doménech, Josep; Petrylak, Daniel P.. 2011. "Cancer Stem Cells, Kits, and Methods". United States.
    Allowed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/09 Neoplasias Biliares: Visão do anatomo-patologista XVI Congresso Nacional de Radiologia
Sociedade Portuguesa De Radiologia E Medicina Nuclear (Peniche, Portugal)
2023/12/06 Começar um Biobanco – experiências portuguesas Curso de formação avançada em Biobancos para países de fala portuguesa (PALOP).
Instituto de Medicina Molecular (Lisbon, Portugal)
2023/10/18 Tumores Pancreáticos. Taller SEDIA: Curso de correlación radiopatológica. Grandes retos diagnósticos. XXII Congreso SEDIA – Imagen pélvica. Abordaje multidisciplinar
Sociedad Española de Diagnóstico por Imagen del Abdomen (Salamanca, Spain)
2023/09/22 3. A importância dos Biobancos em Oncologia 5º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2022/11/18 Biobanco: conducta para armazenamento e utilização de amostras para investigação. Dilemas éticos em Oncologia. 19º Congresso Nacional de Oncologia
Sociedade Portuguesa de Oncologia (Porto, Portugal)
2022/10/18 PSMA Characteristics and Immunohistochemistry Expression 35th Annual Congress of the European Association of Nuclear Medicine – EANM’22
European Association of Nuclear Medicine (Barcelona, Spain)
2022/03/30 Champalimaud Foundation Biobank Sessão BIOBANCOS II: Experiências Portuguesas
Comissão de Ética do Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisbon, Portugal)
2018/05/04 Biobanco da Fundação Champalimaud - Biópsia líquida. 3rd CHAMPALIMAUD CANCER NURSE CONFERENCE
Fundação Champalimaud (Lisbon, Portugal)
2018/05 Biobanco da FC – biopsia liquida. 3º Congresso de Enfermagem da Fundação Champalimaud
(Portugal)
2018/02 To be or not to be Angels & Demons in rectal cancer: Challenging the dogmas.
Champalimaud Centre for the Unknown (Lisbon, Portugal)
2018 Comparative pathology and molecular characterization of tumors. 16th ASEICA International Congress
(Valencia, Spain)
2016/09 ¿Np63 is critical for progression of high grade non-muscle invasive bladder cancer through deregulation of specific genetic pathways. XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology
European Society of Pathology (Germany)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/03 - 2028/03 Clinical implications of pathologic response to radiotherapy in rectal cancer
Supervisor
 PhD (PhD)
Fundação Champalimaud, Portugal
2025/01/01 - 2026/09/30 Study to compare the activation of the immune system depending on the chemotherapy scheme used together with PEMBROLIZUMAB (immunotherapy) in the pre-surgical treatment of triple-negative breast cancer
Supervisor
2018/09/01 - 2019/08/31 3-Dimensional characterization of PanIN (pancreatic intraepithelial neoplasia) in cleared human pancreatic cancer tissues by multiplex immunofluorescence
Supervisor
2016/09/01 - 2017/08/31 Oligometastatic Prostate Cancer: Characterization of its Molecular Phenotype
Supervisor
2016/09/01 - 2017/08/31 ¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways
Supervisor

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/03/12 - 2025/03/12 Science workshop for 8th-9th graders from Escolas básicas do 2.º ciclo(10:00 to 13:00 - Escola Dr.Azevedo Neves, Amadora; 14:00 to 17:00 – Escola Alto do Lumiar, Lisboa). Activity title: "Discover your own cells", which consists on perfroming a bucal smear, staining it with Diff-Quick and vviewing the cells under a light microscope.
Workshop
 Ciência di Noz Manera (CNM) workshop
2025/02/28 - 2025/02/28 Visita Escolar - Centro Ciência Viva de Bragança. Activity: Discover your own cells.
Workshop
2024/04/01 - 2024/06/30 Phase 3 sessions Ciência di Noz Maneira. Escola básica do 2.º ciclo Dr Azevedo Neves – Damaia, Amadora (7 sessions on Wednesdays).
Workshop
 Phase 3 sessions Ciência di Noz Maneira
2024/02/21 - 2024/02/21 Science workshop for 8th-9th graders from Escolas básicas do 2.º ciclo (10:00 to 13:00 - Escola Alto do Lumiar; 14:00 to 17:00 – Escola Dr.Azevedo Neves), Lisbon. Activity title: "Discover your own cells", which consists on perfroming a bucal smear, staining it with Diff-Quick and vviewing the cells under a light microscope.
Workshop
 Ciência di Noz Manera (CNM) workshop
2023/02/10 - 2023/02/10 Science workshop for 8th-9th graders from Escola básica do 2.º ciclo Prof. Pedro D´Orey da Cunha – Damaia, Amadora, Lisbon. Activity title: "Discover your own cells", which consists on perfroming a bucal smear, staining it with Diff-Quick and vviewing the cells under a light microscope.
Workshop
Fundação Champalimaud, Portugal
2022/09/28 - 2022/09/29 The CaixaResearch Health Meeting is an event designed specifically to bring together all the researchers who received a grant in the CaixaResearch Health 2018 Call. The Project Leaders and Principal Investigators of the 25 projects awarded in any of the 5 areas (Neuroscience, Oncology, Cardiovascular and Metabolic Diseases, Infectious Diseases and Enabling Technologies) are invited to create a multidisciplinary discussion of hot topics in Life Sciences and to share their ideas and experiences for 2 days.
Meeting
 1st CaixaResearch Health meeting
Fundação 'la Caixa', Portugal
2021/12/15 - 2021/12/15 Volunteer in the Mentorship program “Ciência di Noz Manera”, performing a workshop on Cell Biology for 8th and 9th graders at the Escola Pedro D’Orey da Cunha in Damaia (Lisbon suburbs), to promote science in underserved communities, with focus in STEM groups.
Workshop
 Ciência di Noz Manera
2019/11/15 - 2019/11/15 Moderator in the Pancreatic Cancer – From Cell Biology to Treatment. Session III. Symposium on Imaging Hallmarks of Cancer. Fundação Champalimaud
Conference
 Symposium on Imaging Hallmarks of Cancer
Fundação Champalimaud, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/25 Unravelling how melanoma extracellular vesicles establish pre-metastatic niches in the lung
(Thesis) Main arguer
 Maria João Teixeira da Costa de Almeida (Master)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2024/09 The Potential of Natural Killer cells in Pancreatic Cancer: from Exploring Tumor-infiltrating Lymphocytes to novel CAR-NK cell Therapy
Supervisor
 Andreia Filipa Garrido Maia (PhD)
Universidade Nova de Lisboa Medical School, Portugal

Association member

Society Organization name Role
2022/02/10 - Current • Graduate Women in Science (GWIS) member
2016/02/01 - Current European Association of Cancer research (EACR) Member
2016/02/01 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2013/10/01 - Current International Society of Urological Pathology (ISUP) Member
2013/03/01 - Current American Association of Cancer Research (AACR) Member
2011/12/01 - Current United States and Canadian Academy of Pathology (USCAP) Member
2002/05/01 - Current Societat Catalana de Citopatologia Member
2002/05/01 - Current Societat Catalana d’Anatomia Patologica Member
1998/09/01 - Current Academia de Ciències Mèdiques de Catalunya i Balears Member

Committee member

Activity description
Role 		Institution / Organization
2024/09/09 - 2029/08/31 Member of the PhD Thesis Advisory Committee of Inês Ribeiro, MSc. from the Glycoimmunology lab of NOVA FCT, with the project entitled “The Potential of Sialyl-Tn as a Novel Therapeutic Target for Pancreatic Cancer”.
Advisor / Consultant
 Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
2021/01/01 - 2024/01/05 Member of the PhD thesis Committe of Julia Elzanowska entitled “Extracellular Vesicles Molecular Cargo as Cancer Biomarkers: Insights into EV-DNA Preparation and EV Protein Interactions”. Defended on the 5th of January 2024
Member
 Fundação Champalimaud, Portugal

Conference scientific committee

Conference name Conference host
2022/05/27 - 2022/05/28 XV Congrés de la Societat Catalana d’Anatomia Patològica Societat Catalana d'Anatomia Patològica

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10 - Current Multispectral microscopy for tumor characterization. (Doutoramento) Programa Champalimaud de Neurociências, Portugal
2019/06 - Current Biobanks: Best practices for specimen collection, processing and storage.
2017/06 - Current Que futuro para os biobancos? Sustentabilidade dos biobancos. Privados vs. Públicos.
2024/10/09 - 2024/10/09 Mesa Redonda: Começar um biobanco – experiências portuguesas. (Outros) Gulbenkian Institute for Molecular Medicine, Portugal
2021/02/22 - 2021/02/22 Molecular Pathology. Impact in oncological patient's management. (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019/07/01 - Current The Journal of Pathology (1096-9896) Wiley (John Wiley & Sons)
2015/05/01 - Current SpringerPlus (2193-1801) Springer (Biomed Central Ltd.)
2014/07/01 - Current PLoS ONE (1932-6203) Public Library of Science
2013/02/01 - Current Journal of Dermatological Science
2011/07/01 - Current European Urology

Mentoring / Tutoring

Topic Student name
2024/03/01 - 2028/03/31 Clinical implications of pathologic response to radiotherapy in rectal cancer José Gonçalves Moreira de Azevedo
2025/01/01 - 2025/07/31 Study to compare the activation of the immune system depending on the chemotherapy scheme used together with PEMBROLIZUMAB (immunotherapy) in the pre-surgical treatment of triple-negative breast cancer Diogo Ferreira
2022/09/01 - 2024/11/13 Can response to chemotherapy be predicted by studying inflammatory cells in the tumour microenvironment of pancreatic cancer? Andreia Lopes
2020/01/01 - 2024/03/01 Expansion of Natural Killer cells as a complementary approach for adoptive cell therapy in advanced Colorectal Cancer (NKAT-CRC) Andreia Filipa Garrido Maia
2021/10/04 - 2023/11/19 Characterisation of the colon adenocarcinoma microenvironment with a focus on Natural Killer cells Hasti António Meggi Calá
2020/09/01 - 2021/08/31 Unraveling the importance of HLA class I in colorectal cancer cell stemness and tumor initiation Ana Raquel Borralho
2020/09/01 - 2021/08/31 Molecular phenotyping of prostate cancer microenvironment, with emphasis in fibroblast activation Sara Cascais
2019/09/01 - 2021/08/31 Do MHC Class I Negative Tumour Cells Display the Cancer Stem Cell Property of Chemoresistance? Unravelling the Mechanisms Cátia Rebelo
2019/07/01 - 2020/06/30 Immune infiltrates analysis for prediction of response to chemoradiotherapy in rectal cancer Inês Franco
2018/09/01 - 2019/08/31 3-Dimensional characterization of PanIN (pancreatic intraepithelial neoplasia) in cleared human pancreatic cancer tissues by multiplex immunofluorescence Susana Canastra Dias
2019/02/01 - 2019/05/31 Immune infiltrates analysis for prediction of response to chemoradiotherapy in rectal cancer Ana Borralho
2016/09/01 - 2017/08/31 Oligometastatic Prostate Cancer: Characterization of its Molecular Phenotype Sara Trinidade Correia
2016/09/01 - 2017/08/31 ¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways Andreia Filipa Garrido Maia

Other jury / evaluation

Activity description Institution / Organization
2023/12/19 - 2023/12/19 Jury of the Master Thesis by Inês Saldanha entitled “Extracellular Vesicles as biomarkers of hepatic metastasis in pancreatic cancer patients”. Defended on the 19th of December Fundação Champalimaud, Portugal
Distinctions

Award

2023 2º Prémio Ultrasound Imaging Price
Grupo Portugues de Ultrassons em Gastroenterologia, Portugal
2020 Menção Honrosa for the project entitled: Expansion of Natural Killer cells as a complementary approach for adoptive cell therapy in advanced Colorectal and Pancreatic Cancer (NKAT-CRC-PDAC).
2020 Menção Honrosa for the project entitled: Zebrafish Avatars, towards personalized cancer treatment.
2017 Image of the Month Award- September 2017
European Association For Cancer Research, United Kingdom
2012 Young Physician-Scientist Award
SASS Foundation, United States
2002 Award at the end of Residency
Hospital Clínic de Barcelona, Spain