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Patrick Silva graduated in Biomedical Pharmacy (2012-2015) from the Faculty of Pharmacy of the University of Coimbra. In 2017, he obtained his Master's Degree in Applied Pharmacology. In the scope of his thesis project, a Portuguese cohort of Machado-Joseph disease patients were characterized, and a preclinical pharmacokinetic study of a compound believed to be translated into a clinical setting soon was performed. After finishing his Master's Degree, Patrick received a Master's holder Research Fellowship joining the research team for the project European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI), co-funded by the Fundação para a Ciência e a Tecnologia (FCT) within the EU Joint Programme – Neurodegenerative Disease Research (JPND). Since October 2019, Patrick has been working on his PhD project entitled "Finding a blood-based biomarker for Machado-Joseph Disease: an integrated approach". Along his academic course, and due to his permanent interest in clinical studies, Patrick got admitted (twice) to an internship as a clinical research coordinator (CRC), totalling 12 months. In addition, he has also developed and got involved in several side-projects in the context of promoting quality of life in the ageing population, developing ideas and participating in science marathons.
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Identification

Personal identification

Full name
Patrick Silva

Citation names

  • Silva, Patrick

Author identifiers

Ciência ID
CF14-CED8-18D1
ORCID iD
0000-0002-5436-8949

Email addresses

  • pjsilva@cnc.uc.pt (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Addresses

  • CNC - Centro de Neurociências e Biologia Celular. Rua Larga, Edifício da Faculdade de Medicina, Pólo I, 2º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Advanced (C1)
French Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2019/10/17 - 2023
Ongoing
 Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/02 - 2021/03/08
Concluded
 The Data Scientist's Toolbox (Outros)
Johns Hopkins University, United States
 98.9%
2020/10/12 - 2020/10/16
Attended
 Summer School in Bioinformatics 2020 - Virtual (Outros)
European Bioinformatics Institute, United Kingdom
2020/04 - 2020/06
Concluded
 Design and Interpretation of Clinical Trials (Outros)
Johns Hopkins University, United States
 100%
2020/03/29 - 2020/03/31
Concluded
 The Essentials of Data Management (Outros)
Secretaria-Geral da Educação e Ciência, Portugal
2020/02/24 - 2020/02/28
Concluded
 Computational Biology (Outros)
Centro de Neurociências e Biologia Celular, Portugal
 19
2019/04 - 2019/07
Concluded
 Statistical and Multivariate Analysis in R: Applications in Multiple Component Systems (Outros)
Universidade de Coimbra, Portugal
 20
2015/09/24 - 2017/10/17
Concluded
 Applied Pharmacology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Machado-Joseph Disease: Understanding Epidemiologic and Clinical Features and a Potential New Therapeutic Entity" (THESIS/DISSERTATION)
 17.258
2016
Concluded
 Good Clinical Practices (Outros)
National Institute on Drug Abuse Clinical Trials Network, United States
2012/09/10 - 2015/07/06
Concluded
 Biomedical Pharmacy (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 14.311
Affiliation

Science

Category
Host institution 		Employer
2019/10 - Current Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/04/16 - 2019/09/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2017/11/01 - 2018/03/30 Internship - Clinical Research Coordinator Unidade de Investigação Clínica em Cardiologia, Portugal
Hospitais da Universidade de Coimbra, Portugal
2015/11/30 - 2016/05/27 Internship - Clinical Research Coordinator Unidade de Investigação Clínica em Cardiologia, Portugal
Hospitais da Universidade de Coimbra, Portugal
Projects

Grant

Designation Funders
2023/03/01 - 2024/08/31 From “bedside-to-bench” biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease
2022.06118.PTDC
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/10/01 - 2023/09/30 Finding a blood-based biomarker for Machado-Joseph Disease: an integrated approach
SFRH/BD/148451/2019
PhD Student Fellow
Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/04/16 - 2019/09/30 JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
info:eu-repo/grantAgreement/RCUK/MRC/MR2%FN0287672%F1/GB
Research Fellow
CNC.IBILI, Portugal
 UK Research and Innovation
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020/04 - 2020/07 Covid-19 Lab @ CNC / ViraVector
na
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Cunha, Inês; Silva, Patrick; Joana Afonso Ribeiro; Magda M Santana; Pereira de Almeida, Luís; Januário, Cristina. "Predictors of quality of life in Machado-Joseph disease: A longitudinal observational study". Paper presented in MDS Virtual Congress 2020, 2020.
    Published
  2. Magda M Santana; Silva, Patrick; Gaspar, Laetitia; Henriques, Carina; Joana Afonso Ribeiro; Cunha, Inês; Nobre, Rui Jorge; Januário, Cristina; Pereira de Almeida, Luís. Corresponding author: Magda M Santana. "miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls". Paper presented in 23rd Annual Meeting of the Portuguese Society of Human Genetics, Coimbra, 2020.
    Published
  3. Brás, A; Cunha, Inês; Silva, Patrick; Joana Afonso Ribeiro; Santana, Magda M; Pereira de Almeida, Luís; Januário, Cristina. Corresponding author: Brás, A. "Characterization of a Portuguese cohort of Machado-Joseph disease: besides ataxia". Paper presented in 5th Congress of the European Academy of Neurology, Oslo, 2019.
    Published
  4. Santana, Magda M; Silva, Patrick; Joana Afonso Ribeiro; Cunha, Inês; Gaspar, Laetitia; Cristina Januário; Luís Fernando Morgado Pereira de Almeida. Corresponding author: Santana, Magda M. "Characterization and follow-up of the Coimbra cohort of Machado-Joseph disease patients". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
Conference poster
  1. Silva, Patrick; Santana, Magda M.; Pinto, Maria M.; Gaspar, Laetitia; Nobre, Rui Jorge; Duarte, Sónia; Marques, Tânia M.; et al. "Discriminating spinocerebellar ataxia type 3 ataxic mutation carriers from control and preataxic through miRNA expression profiles in plasma-derived extracellular vesicles". Paper presented in he Non- Coding Genome Symposium, 2023.
  2. Silva, Patrick; Santana, Magda M; Pinto, Maria; Gaspar, Laetitia S; Nobre, Rui Jorge; Duarte, Sónia; Monteiro Marques, Tania; et al. "Discrimitating spinocerebellar ataxia type 3 ataxic mutation carriers from control and pre-ataxic throuh miRNA expression profiles in plasma-derived extracellular vesicles". Paper presented in EMBO|EMBL Symposium: The non-coding genome, 2023.
  3. Pinto, Maria; Silva, Patrick; Gaspar, Laetitia S; Henriques, Carina; Nobre, Rui Jorge; Cunha, Inês; Ribeiro, Joana; et al. "Biomarkers for Machado-Joseph Disease: microRNAs in plasma-derived extracellular vesicles as potential candidates.". Paper presented in Student Network on Extracellular Vesicles International Online Conference, 2021.
  4. Magda M Santana; Silva, Patrick; Gaspar, Laetitia S; Pinto, Maria Manuel ; Carina Henriques; Joana Ribeiro; Inês Cunha; et al. "miRNA expression profile of plasma-derived extracellular from Machado-Joseph Disease patients.". Paper presented in SCA global and ARCA global, 2020.
  5. Silva, P.; Santana, Magda Matos; Cunha, Inês; Ribeiro, Joana; Pereira, Dina; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Portuguese-mainland cohort of Machado-Joseph Disease: what can be seen after one-year follow-up?". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  6. Santana, Magda M; Silva, P.; Ribeiro, Joana; Cunha, Inês; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Characterization of the Coimbra cohort of Machado-Joseph Disease patients for future clinical trials". Paper presented in 1st SCA Global Conference, 2019.
Journal article
  1. Hengel, Holger; Martus, Peter; Faber, Jennifer; Giunti, Paola; Garcia-Moreno, Hector; Solanky, Nita; Klockgether, Thomas; et al. "Correction to: The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors". Journal of Neurology 271 1 (2023): 628-629. http://dx.doi.org/10.1007/s00415-023-12064-8.
    10.1007/s00415-023-12064-8
  2. Faber, Jennifer; Berger, Moritz; Wilke, Carlo; Hübener-Schmid, Jeannette; Schaprian, Tamara; Santana, Magda M; Grobe-Einsler, Marcus; et al. Corresponding author: Faber, Jennifer. "Stage-Dependent Biomarker Changes in Spinocerebellar Ataxia Type 3". Annals of Neurology 95 2 (2023): 400-406.
    Open access • Published
  3. Raposo, Mafalda; Hübener-Schmid, Jeannette; Ferreira, Ana F; Vieira Melo, Ana Rosa; Vasconcelos, João; Pires, Paula; Kay, Teresa; et al. "Blood transcriptome sequencing identifies biomarkers able to track disease stages in spinocerebellar ataxia type 3". Brain (2023): http://dx.doi.org/10.1093/brain/awad128.
    10.1093/brain/awad128
  4. Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al. "A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia". Neuropathology and Applied Neurobiology 49 2 (2023): http://dx.doi.org/10.1111/nan.12892.
    10.1111/nan.12892
  5. Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al. "A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia". Neuropathology and Applied Neurobiology (2023): https://doi.org/10.1111/nan.12892.
    Published
  6. Hengel, Holger; Martus, Peter; Faber, Jennifer; Giunit, Paola; Garcia-Moreno, Hector; Solanky, Nita; Klockgether, Thomas; et al. "The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors". Journal of Neurology 270 2 (2022): 944-952. http://dx.doi.org/10.1007/s00415-022-11441-z.
    10.1007/s00415-022-11441-z
  7. Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto Rolim Muro Martinez; Marcondes Cavalcante França Jr; Clévio Nóbrega; Luís Pereira de Almeida. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology (2022): https://doi.org/10.1111/nan.12763.
    10.1111/nan.12763
  8. Hengel, Holger; Martus, Peter; Faber, Jennifer; Garcia-Moreno, Hector; Solanky, Nita; Giunti, Paola; Klockgether, Thomas; et al. "Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity". Movement Disorders 37 2 (2021): 405-410. http://dx.doi.org/10.1002/mds.28844.
    Open access • Published • 10.1002/mds.28844
Newspaper article
  1. Vinhas, Catarina Ana; Ferreira, Ana Cristina; Henriques, Carina; Silva, Carolina; Miranda, Catarina; Henriques, Daniel; Oliveira, Daniela; et al. "Uma viagem rara", PÚBLICO, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. Silva, Patrick Joel da. "Machado-Joseph Disease: Understanding Epidemiologic and Clinical Features and a Potential New Therapeutic Entity". Master, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2017. http://hdl.handle.net/10316/83750.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/03 Plasma-derived extracellular vesicles from Machado-Joseph disease/Spinocerebellar ataxia type 3 ataxic patients are enriched in mitochondrial, nuclear and nucleolar small RNA species 53rd Meeting of the Portuguese Society of Pharmacology
Faculty of Medicine of the University of Coimbra (Coimbra, Portugal)
2022/02/10 Medication patterns of Machado-Joseph disease patients enrolled in the ESMI cohort: a retrospective study LII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2021/02/19 European spinocerebellaar ataxia type 3/Machado-Joseph disease initiative: clinical overview of the Coimbra's cohort 51.ª Reunião da Sociedade Portuguesa de Farmacologia
Faculty of Farmacy of the University of Lisbon (Lisbon, Portugal)
2020/02 Proteomic identification of a set of serum proteins with potential to be used as biomarkers for Machado-Joseph Disease L Annual Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2019/11 miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls 23rd Annual Meeting, Portuguese Society of Human Genetics
(C, Portugal)
2019/05 Characterization and follow-up of the Coimbra cohort of Machado-Joseph Disease patients 53rd Annual Scientific Meeting, European Society for Clinical Investigation
(Coimbra, Portugal)
2019/02 Characterization of a trial-ready Portuguese cohort of Machado-Joseph Disease: status update XLIX Annual Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2018/11 Doença de Machado-Joseph: muito para além da ataxia 2018 Congress of Neurology
Portuguese Society of Neurology (Porto, Portugal)
2018/02 Characterization of a trial-ready Portuguese cohort of Machado-Joseph Disease patients XLIII Annual Meeting of the Portuguese Society of Pharmacology
(Lisbon, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/01/13 - 2020/02/29 Machado-Joseph Disease: From Laboratory to Society – Rare Disease Day 2020 @ Centre for Neuroscience and Cell Biology (2020/02/29 - 2020/02/29)
Meeting (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/11/01 - 2015/06/01 Queima das Fitas 2015 (Infrastructures Division) (2015/05/08 - 2015/05/15)
Festival (Other)
 Associação Académica da Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/05/05 - 2018/05/06 Hack for Good 2018, Calouste Gulbenkian Foundation. Porto, Portugal. May 2018
Other
 Hack for Good 2018
Fundação Calouste Gulbenkian, Portugal
2018/04 - 2018/05 IneoStart’18, Pedro Nunes Institute. Coimbra, Portugal. April to May 2018. IneoStart’18
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2017/09/30 - 2017/10/01 AAL Hackathon 2017 – Hack 4 Ageing Well, AAL Programme. Coimbra, Portugal. September 2017
Other
 AAL Hackathon 2017 – Hack 4 Ageing Well
Active and Assisted Living association, Luxembourg
Distinctions

Award

2019 2nd Price in Hackathon 2017 – Hack 4 Ageing Well
Active and Assisted Living association, Luxembourg

Other distinction

2020 2016/2017 Academic Year Merit Scholarship
Direção-Geral do Ensino Superior, Portugal