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Nuna Araújo. Completed the Doutoramento in PhD in Medicinal Organic Chemistry in 2004/12/15 by University of Liverpool Department of Chemistry, Mestrado in Mestrado Integrado em Ciências Farmacêuticas in 2014 by Universidade do Algarve Faculdade de Ciências e Tecnologia and Licenciatura in Licenciatura em Bioquímica in 1999 by Universidade do Algarve Faculdade de Ciências e Tecnologia. Attends the Doutoramento in Doutoramento em Ciências Biomédicas by Universidade do Algarve since 2016/01/01. Published 16 articles in journals. Participates and/or participated as Research Fellow in 1 project(s) and Researcher in 2 project(s).
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Identification

Personal identification

Full name
Nuna Araújo

Citation names

  • Araújo, Nuna

Author identifiers

Ciência ID
CD1B-789D-642A

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2016/01/01 - 2020
Ongoing
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2014
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Toxicidade inerente ao uso de antimaláricos endoperoxídicos" (THESIS/DISSERTATION)
 14/20
2004/12/15
Concluded
 PhD in Medicinal Organic Chemistry (Doutoramento)
University of Liverpool Department of Chemistry, United Kingdom
"New concepts for malaria chemotherapy and approaches to improved antimalarial endoperoxides" (THESIS/DISSERTATION)
 n/a
1999
Concluded
 Licenciatura em Bioquímica (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Síntese e Reactividade de éteres aromáticos benzílicos de sacarina e tetrazol" (THESIS/DISSERTATION)
 14/20
Affiliation

Science

Category
Host institution 		Employer
2015/06/01 - 2015/12/31 Researcher (Research) Centro de Ciências do Mar, Portugal
2005/05/11 - 2011/05/01 Postdoc (Research) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
1999 - 2000 Researcher (Research) Universidade do Algarve, Portugal

Others

Category
Host institution 		Employer
2016/01/01 - 2019/12/31 PhD in biomedical sciences: ‘Interplay between mineralization and inflammation in vascular calcification and osteoarthritis: extracellular vesicles and marine bioactive compounds as new therapeutic ap Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2015/03/03 - 2015/06/01 Pharmacyst Hospital Particular do Algarve, Portugal
2013/04/01 - 2014/03/15 Pharmacyst Farmácia Baptista, Portugal
Projects

Grant

Designation Funders
2015/10/01 - 2015/12/31 New insights into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP
PTDC/BIM-MEC/1168/2012
Research Fellow
Centro de Ciências do Mar, Portugal
Concluded
2015/06/01 - 2015/09/30 “Elucidação da função e mecanismo de acção molecular da proteína Gla-rich (GRP) na calcificação vascular”
PTDC/SAU-ORG/117266/2010 – BioGlaGRP:
Researcher
Centro de Ciências do Mar, Portugal
Concluded

Contract

Designation Funders
2008/03/01 - 2011/08/31 ARTEMIP- The safety pharmacology of artemisinins when used to reverse pathophysiology of malaria in pregnacy
FP7 Contract 200805.
Researcher
Concluded
Outputs

Publications

Conference paper
  1. Araújo, Nuna; Carla Viegas; Jorge Pontes; Catarina Marreiros; Pedro Raimundo; Anjos L Macedo; António Alves de Matos; et al. "Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)". Paper presented in 4th International Congress of CiiEM- Research and Innovation in Human & Health Sciences, Caparica-Almada, 2019.
    In press
Conference poster
  1. Araújo, Nuna. "Nano-encapsulation of gla-rich protein (GRP) and potential added value as a therapeutic agent for osteoarthritis". Paper presented in 21st International Symposium on Microencapsulation., 2017.
  2. Araújo, Nuna. "Exploring meroterpenoids from brown algae as novel therapeutic drugs for osteoarthritis". Paper presented in XV International Symposium on Marine Natural Products - MaNaPro, 2016.
  3. Araújo, Nuna. "Design and Synthesis of Endoperoxide Hybrids Directed to Plasmodial DNA". Paper presented in 2ºEncontro Nacionl de Química Terapêutica, 28 - 30 Nov 2010, Coimbra, poster nº78., 2010.
  4. Araújo, Nuna. "Synthesis of New Peptidic Cysteine Protease Inhibitors". Paper presented in 1º Encontro Nacional de Química Terapêutica, 2008.
  5. Araújo, Nuna. "Design and Synthesis of Plasmodium DNA-Directed Endoperoxides". Paper presented in 1º Encontro Nacional de Química Terapêutica, 2008.
  6. Araújo, Nuna. "DNA-Directed endoperoxides". Paper presented in XXth International Symposium on Medicinal Chemistry, 2008.
  7. Araújo, Nuna. "New Potential Plasmodium Cysteine Protease Inhibitors Incorporating Tetrazoles". Paper presented in 11th European Symposium on Organic Reactivity (ESOR 11), 2007.
  8. Araújo, Nuna. "New DNA- directed endoperoxides". Paper presented in 11th European Symposium on Organic Reactivity (ESOR 11), Faro, July 01-06, 2007, poster nº4., 2007.
  9. Araújo, Nuna. "New DNA-Directed Endoperoxides". Paper presented in Medicinal Chemistry in the 21st Century, 2006.
  10. Araújo, Nuna. "Preparation of New Antimalarial Endoperoxides containing Plasmodium Falcipain-2 Inhibitors". Paper presented in 10th European Symposium on Organic Reactivity (ESOR 10), 2005.
  11. Araújo, Nuna. "Preparation of New Antimalarial Endoperoxides Containing Plasmodium Falcipain-2 Inhibitors". Paper presented in 6º Encontro Nacional de Química Orgânica, 2005.
  12. Araújo, Nuna. "Antimalarial Combination Chemotherapy: Synthesis of Aminoquinoline and Aminoacridine Peroxide Hybrids". Paper presented in Ischia advanced school of organic chemistry: new frontiers and future challenges in organic synthesis, Ischia (Napoli),, 2002.
  13. Araújo, Nuna. "Antimalarial Combination Chemotherapy: Synthesis of New Endoperoxide Hybrids". Paper presented in Annual Postgraduate Poster Day, 21 de Maio de 2002, Universidade de Liverpool., 2002.
  14. Araújo, Nuna. "Hidrogenólise de Derivados Heteroaromáticos de Alcoois Benzílicos". Paper presented in XII Encontro Luso-Galego de Química, 1998.
Journal article
  1. Pedrosa, Rui; P. Gaudêncio, Susana; Vasconcelos, Vitor. "XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products". Marine Drugs 18 1 (2020): 27-27. http://dx.doi.org/10.3390/md18010040.
    Published • 10.3390/md18010040
  2. Simes, Dina C.; Viegas, Carla S. B.; Araújo, Nuna; Marreiros, Catarina. "Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases". Nutrients 12 1 (2020): 138. http://dx.doi.org/10.3390/nu12010138.
    Published • 10.3390/nu12010138
  3. Simes, Dina C.; Viegas, Carla S. B.; Araújo, Nuna; Marreiros, Catarina. "Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies". International Journal of Molecular Sciences 20 17 (2019): 4150. http://dx.doi.org/10.3390/ijms20174150.
    Published • 10.3390/ijms20174150
  4. Viegas, Carla; Araújo, Nuna; Marreiros, Catarina; Simes, Dina. "The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts". Aging 11 12 (2019): 4274-4299. http://dx.doi.org/10.18632/aging.102046.
    10.18632/aging.102046
  5. Araújo, Nuna; Viegas, Carla; Perrolas, Inês; Costa, Rúben; Magalhães, Joana; Blanco, Francisco; Ramos, Acácio; et al. "Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay". Annals of Medicine 51 sup1 (2019): 43-43. http://dx.doi.org/10.1080/07853890.2018.1561895.
    Published • 10.1080/07853890.2018.1561895
  6. Viegas, Carla; Edelweiss, Evelina; Schneider, Justine; Schaeffer-Reiss, Christine; Poterszman, Arnaud; Rafael, Marta; Araújo, Nuna; et al. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of Medicine 51 sup1 (2019): 38-38. http://dx.doi.org/10.1080/07853890.2018.1561804.
    Published • 10.1080/07853890.2018.1561804
  7. Viegas, Carla S. B.; Costa, Rúben M.; Santos, Lúcia; Videira, Paula A.; Silva, Zélia; Araújo, Nuna; Macedo, Anjos L.; et al. "Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases". PLOS ONE 12 5 (2017): e0177829. http://dx.doi.org/10.1371/journal.pone.0177829.
    Published • 10.1371/journal.pone.0177829
  8. Araujo, N.C.P.; Afonso, R.; Bringela, A.; Cancela, M.L.; Cristiano, M.L.S.; Leite, R.B.. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International 62 6 (2013): 575-582. http://dx.doi.org/10.1016/j.parint.2013.06.010.
    Published • 10.1016/j.parint.2013.06.010
  9. La Pensée, Louise; Sabbani, Sunil; Sharma, Raman; Bhamra, Inder; Shore, Emma; Chadwick, Amy E.; Berry, Neil G.; et al. "Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation". ChemMedChem 8 5 (2013): 709-718. http://dx.doi.org/10.1002/cmdc.201200536.
    Published • 10.1002/cmdc.201200536
  10. Gibbons, Peter; Verissimo, Edite; Araujo, Nuna C.; Barton, Victoria; Nixon, Gemma L.; Amewu, Richard K.; Chadwick, James; et al. "Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity". Journal of Medicinal Chemistry 53 22 (2010): 8202-8206. http://dx.doi.org/10.1021/jm1009567.
    Published • 10.1021/jm1009567
  11. Araújo, Nuna C.P.; Barton, Victoria; Jones, Michael; Stocks, Paul A.; Ward, Stephen A.; Davies, Jill; Bray, Patrick G.; et al. "Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates". Bioorganic & Medicinal Chemistry Letters 19 7 (2009): 2038-2043. http://dx.doi.org/10.1016/j.bmcl.2009.02.013.
    Published • 10.1016/j.bmcl.2009.02.013
  12. Stocks, Paul A.; Bray, Patrick G.; Barton, Victoria E.; Al-Helal, Mohammed; Jones, Michael; Araujo, Nuna C.; Gibbons, Peter; et al. "Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs". Angewandte Chemie International Edition 46 33 (2007): 6278-6283. http://dx.doi.org/10.1002/anie.200604697.
    Published • 10.1002/anie.200604697
  13. O’Neill, Paul M.; Verissimo, Edite; Ward, Stephen A.; Davies, Jill; Korshin, Edward E.; Araujo, Nuna; Pugh, Matthew D.; et al. "Diels–Alder/thiol–olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore". Bioorganic & Medicinal Chemistry Letters 16 11 (2006): 2991-2995. http://dx.doi.org/10.1016/j.bmcl.2006.02.059.
    Published • 10.1016/j.bmcl.2006.02.059
  14. O’Neill, Paul M.; Verissimo, Edite; Ward, Stephen A.; Davies, Jill; Korshin, Edward E.; Araujo, Nuna; Pugh, Matthew D.; et al. "Diels–Alder/thiol–olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore". Bioorganic & Medicinal Chemistry Letters 16 11 (2006): 2991-2995. http://dx.doi.org/10.1016/j.bmcl.2006.02.059.
    Published • 10.1016/j.bmcl.2006.02.059
  15. Araújo, Nuna C.P; Brigas, Amadeu F; Cristiano, M.Lurdes S; Frija, Lui´s M.T; Guimarães, Emanuel M.O; Loureiro, Rui M.S. "Heteroaromatic benzyl ethers as intermediates for palladium-catalysed transfer hydrogenolysis of benzyl alcohols". Journal of Molecular Catalysis A: Chemical 215 1-2 (2004): 113-120. http://dx.doi.org/10.1016/j.molcata.2003.12.033.
    Published • 10.1016/j.molcata.2003.12.033
  16. Araújo, Nuna C. P.; Barroca, Pedro M. M.; Bickley, Jamie F.; Brigas, Amadeu F.; Cristiano, M. Lurdes S.; Johnstone, Robert A. W.; Loureiro, Rui M. S.; Pena, Paula C. A.. "Structural effects on sigmatropic shifts in heteroaromatic allyl ethersElectronic supplementary information (ESI) available: selected crystal data for compound 7. See http://www.rsc.org/suppdata/p1/b1/b102674g/". Journal of the Chemical Society, Perkin Transactions 1 9 (2002): 1213-1219. http://dx.doi.org/10.1039/b102674g.
    Published • 10.1039/b102674g
Thesis / Dissertation
  1. Araújo, Nuna. "Estudo da toxicidade inerente à utilização de Artemisinina e derivados no tratamento de malária". Master, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2014.
  2. Araújo, Nuna. "New Concepts for Malaria Chemotherapy and Approaches to Improved Antimalarial Endoperoxides". PhD, University of Liverpool Department of Chemistry, 2004.
  3. Araújo, Nuna. "Redução Catalítica por Transferência de Hidrogénio em compostos Heteroaromáticos com Potencial Actividade Biológica". Degree, Universidade do Algarve Faculdade de Ciências e Tecnologia, 1998.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09/01 Amentadione, a Meroditerpenoide from Brown Algae with Capacity of Modulating Osteoarthritic Responses, In a Close-to-in vivo OA Mode 4th International Congress of CiiEM- Research and Innovation in Human & Health Sciences
(Caparica-Almada, Portugal)
2018/06/20 Nano-encapsulation as a novel delivery approach for therapeutic gla-rich protein (GRP) applications 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences
(Monte da Caparica, Costa da Caparica- Almada, Portugal)
2018/06/20 Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP) 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences,
(Caparica-Almada, Portugal)
2018/06/20 Amentadione is a new modulating agent for osteoarthritis in an ex-vivo coculture preclinical assay 3rd International Congress of CiiEM, Research and Innovation in Human Health Science
(Caparica-Almada, Portugal)
2010/11/28 New Peptidic Cysteine Protease Inhibitors 2º Encontro Nacional de Química Terapêutica
(Coimbra, Portugal)
2009/12/17 New approaches to Antimalarial drug design; Plasmodium DNA-Directed Endoperoxides Plataforma Ibérica de Malária, 2nd Meeting
N.C.P Araújo, L.I.L. Cabral, P.M. O’Neill, (Spain)
2008/11/13 Design and Synthesis of Plasmodium DNA-Directed Endoperoxides 1º Encontro Nacional de Química Terapêutica
(Porto, Portugal)
2006/10/13 Fighting Back Malaria… Medicinal Chemistry in the 21st Century
(Lisboa, Portugal)
2006/08/29 The Drug-Hybrid Approach to Antimalarial Chemotherapy IXth International Symposium on Medicinal Chemistry
(Istanbul, Turkey)
1999/06/23 Synthesis and Reactivity of Benzylic Derivates 3º Encontro Nacional de Química Orgânica
(Covilhã, Portugal)