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Nuno C. Santos was born in Lisbon, Portugal, in 1972. He graduated in Biochemistry from the Faculty of Science, University of Lisbon, in 1995, and received his PhD in Theoretical and Experimental Biochemistry in 1999 from the same University, although all the experimental work was conducted at Instituto Superior Técnico (Technical University of Lisbon) and University of California (Santa Barbara). Currently, he is Associate Professor with Habilitation of the Faculty of Medicine, University of Lisbon, and Head of the Biomembranes & Nanomedicine Unit at the Gulbenkian Institute for Molecular Medicine (GIMM), which was created in 2024 upon the merging between Instituto de Medicina Molecular (iMM), where he was previously Group Leader, and Instituto Gulbenkian de Ciência (IGC). Among other distinctions, his research work was awarded with the Gulbenkian Prize for young researchers (2001), Dr. José Luis Champalimaud Prize – Basic Research (2004), Dr. José Luis Champalimaud Prize – Applied Research and Technology (2005) and the ULisboa – Caixa Geral de Depósitos Prize (2017 and 2023). He is (co)author of 194 articles in per-reviewed international journals, which received more than 11 300 citations (h index 57 and i10-index 151, publishing since 1996), presenting a Journal Citation Reports impact factor sum of 1069.0 (average 5.6 per article). In addition to these publications, he (co)authored 10 articles in Portuguese scientific journals, 15 book chapters (mostly published outside Portugal, in English), 3 books (editor, published by Wiley, Springer and MDPI) and 2 international patents. Among different National and International research projects, he was the coordinator of a European Union-funded consortium including 10 different research groups from Europe and Brazil. His Lab is currently involved in 9 funded research projects (European Commission, la Caixa Foundation, FCT, Portugal 2030) He is member of the Executive Committee of the European Biophysical Societies’ Association (EBSA) since 2019, and the Director of the M2B-PhD Doctoral Program in Medical Biochemistry and Biophysics (involving 5 different institutions) since 2016. He was President of the Portuguese Biophysical Society from 2015 to 2021. He has supervised 17 completed PhDs, 10 as main supervisor and 7 as co-supervisor. (April 2025)
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Identification

Personal identification

Full name
Nuno Fernando Duarte Cordeiro Correia dos Santos

Citation names

  • Santos, Nuno C.
  • Santos, N.C.

Author identifiers

Ciência ID
CD13-5E3A-A3C5
ORCID iD
0000-0002-0580-0475
Google Scholar ID
hmISCFoAAAAJ&hl

Email addresses

  • nsantos@medicina.ulisboa.pt (Professional)
  • nsantos@fm.ul.pt (Professional)
  • nuno.santos@gimm.pt (Professional)

Addresses

  • Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Virology
  • Engineering and Technology - Nano-technology
  • Engineering and Technology - Medical Engineering - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2010/06/15
Concluded
 Ciências Biomédicas (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
1999/11/16
Concluded
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

University of California Santa Barbara Department of Chemical Engineering, United States
1995/07/20
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16.5
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Principal Investigator (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2008/01/01 - 2024/09/30 Principal Investigator (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
1994/09/01 - 1999/02/28 Researcher (Research) Universidade de Lisboa Centro de Química-Física Molecular, Portugal
1997/02/01 - 1997/05/31 Visiting Researcher (Research) University of California at Santa Barbara, United States

Teaching in Higher Education

Category
Host institution 		Employer
2013 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2000/03/01 - 2010/06/15 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
1999/03/01 - 2000/02/29 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2023/10 - 2025/10 COLOR2COAT: Nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars (CI23-10134)
CI23-10134
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Ongoing
2021/03/29 - 2024/03/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/04/01 - 2023/03/31 SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH.
info:eu-repo/grantAgreement/EC/H2020/814607/EU
Researcher
European Commission
Ongoing
2018/10/01 - 2021/09/30 iDNArT - Intelligent DNA nanostructures aimed at brain therapeutics
PTDC/NAN-MAT/30898/2017
Researcher
Ongoing
2018/10/01 - 2021/09/30 When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity?
PTDC/BIA-CEL/28456/2017
Researcher
Ongoing
2016/05/01 - 2019/10/31 Broad-spectrum antiviral peptides against respiratory viruses
PTDC/BBB-BQB/3494/2014
Principal investigator
Concluded
2016/05/01 - 2019/10/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies
PTDC/BBB-BMD/6307/2014
Researcher
Concluded
2015/02/01 - 2019/01/31 Engineering protease-resistant alpha-beta peptides for broad-spectrum antivirals
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/5R01AI114736-04/US
Researcher
2015/02/01 - 2019/01/31 Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.
info:eu-repo/grantAgreement/EC/H2020/644167/EU
Researcher
Concluded
2012/03/01 - 2015/08/31 AMYLOIDETECTORS: Employing amyloid fibrils as biosensors of the interaction of peptides with phospholipids and/or protein domains.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/117013/PT
Researcher
Concluded
2012/03/01 - 2015/08/31 Molecular characterization of the fibrinogen-eryhthrocyte interaction and its influence on Cardivascular pathologies
info:eu-repo/grantAgreement/FCT/3599-PPCDT/119509/PT
Principal investigator
Concluded
2012/02/01 - 2015/01/31 ADHESION, DIFFERENTIATION AND INVASION: DIFFERENT PROCESSES, COMMON CADHERIN PLAYERS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F757052%F2011/PT
Researcher
Concluded
2011/03/01 - 2014/08/31 Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/114774/PT
Researcher
Concluded
2011/03/01 - 2014/08/31 LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112929/PT
Researcher
Concluded
2010/01/31 - 2014 Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration.
info:eu-repo/grantAgreement/EC/FP7/247513/EU
Principal investigator
Concluded
2011/07/15 - 2013/03/31 Cell membrane features in HIV entry and its inhibition
info:eu-repo/grantAgreement/FCT/3599-PPCDT/104787/PT
Principal investigator
Concluded
2009/03/01 - 2013/02/28 Selected peptides as drug candidates directed to pain and neurodegeneration
info:eu-repo/grantAgreement/EC/FP7/230654/EU
Researcher
Concluded
2010/02/01 - 2013/01/31 Inherent antibacterial activity in peptide-based hydrogels for tissue regeneration
info:eu-repo/grantAgreement/FCT/3599-PPCDT/99142/PT
Researcher
2010/01/01 - 2012/12/31 MULTI-TARGET HIV ENTRY INHIBITORS DELIVERY BY CATIONIC LIPOSOMES
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F655312%F2009/PT
Researcher
Concluded
2008/02/11 - 2011/06/09 Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/64484/PT
Researcher
Concluded
2009/06/05 - 2011/06/04 The role of lipid membranes in dengue virus assembly
info:eu-repo/grantAgreement/EC/FP7/237373/EU
Supervisor
2007/12/01 - 2011/05/30 The role of lipid membranes in Dengue virus cell infection
info:eu-repo/grantAgreement/FCT/3599-PPCDT/69937/PT
Researcher
Concluded
2007/01/01 - 2010/03/31 Fibrinogen and signal transduction on Microcirculation – Implications in inflammation and cardiovascular diseases
PTDC/SAU-OSM/73449/2006
Researcher
Concluded
2000/11/01 - 2002/10/31 The interaction of HIV-1 membrane protein gp41 fusion peptide with biomembranes and its inhibition
info:eu-repo/grantAgreement/FCT/POCI/12049/PT
Researcher
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute of Molecular Medicine João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2025/06/30 COoperative Mechanical couPling of adherens junctions and focaL adhesIons supporting breast CancEr progression
PTDC/BIA-BFS/0812/2021
10.54499/PTDC/BIA-BFS/0812/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2025/01/31 Biophysical studies of flavivirus capsid protein interactions with key biological targets to achieve its future inhibition
2022.02763.PTDC
10.54499/2022.02763.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2023/03/10 - 2024/12/09 AMP-AgNP conjugates: the mutual reinforcement of antibacterial activity
2022.01991.PTDC
10.54499/2022.01991.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2021/03/29 - 2024/09/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
10.54499/PTDC/EMD-TLM/7289/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/04/01 - 2023/09/30 Unveiling pericyte dynamics during vascular development
EXPL/MED-ANM/1616/2021
10.54499/EXPL/MED-ANM/1616/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/10/31 Broad-spectrum antiviral peptides against respiratory viruses
PTDC/BBB-BQB/3494/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/10/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies
PTDC/BBB-BMD/6307/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/05/01 - 2016/10/31 Multi-target HIV entry inhibitors delivery by cationic liposomes
VIH/SAU/0047/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2016/08/31 An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
HIVERA/0003/2013
Universitat Autònoma de Barcelona, Spain

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centre National de la Recherche Scientifique, France
Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2016/08/31 An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
HIVERA/0002/2013
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centre National de la Recherche Scientifique, France

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/10/31 Adhesion, Differentiation and Invasion: different processes, common cadherin players
PTDC/SAU-GMG/120049/2010
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Molecular characterization of the fibrinogen-eryhthrocyte interaction and its influence on Cardivascular pathologies
PTDC/QUI-BIQ/119509/2010
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies.
PTDC/QUI-BIQ/112929/2009
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Amyloidogenic proteins: role of lipid-protein interaction in amyloid-like fibril formation
PTDC/QUI-BIQ/099947/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universidade de Évora, Portugal

Universidade de Évora Centro de Química de Évora, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/03/31 Cell membrane features in HIV entry and its inhibition
PTDC/QUI-BIQ/104787/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/01/31 Inherent antibacterial activity in peptide-based hydrogels for tissue regeneration
PTDC/SAU-BEB/099142/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

University of Delaware Department of Chemistry & Biochemistry, United States
Fundação para a Ciência e a Tecnologia
Concluded
2008/02/11 - 2011/06/09 Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes
PTDC/QUI/64484/2006
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2024/01 - 2025/01 IMPLAT: A single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants
Project#11 IMPLAT
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Ongoing
Outputs

Publications

Book
  1. Santos, N.C.; Carvalho, F.A.. Preface. 2019.
  2. Lopes, C.S.; Carvalho, F.A.; Santos, N.C.. Atomic force microscopy: A tool for imaging, manipulating biomolecules, and quantifying single-molecule interactions in biological systems. 2017.
  3. Castanho, M.; Santos, N.C.. Preface. 2011.
Book chapter
  1. Freire, João Miguel; Domingues, Marco M.; Matos, Joana; Melo, Manuel N.; Veiga, Ana Salomé; Santos, Nuno C.; Castanho, Miguel A. R. B.. "Quantifying molecular partition of charged molecules by Zeta-potential measurements". European Peptide Society, 2010.
  2. Domingues, Marco; Santos, Nuno C.. "Laser-light scattering approach to peptide–membrane interaction.". In Membrane-active peptides: methods and results on structure and function, 145-168. IUL Biotechnology, 2010.
    Published
  3. Castanho, Miguel A. R. B.; Prieto, Manuel J. E.; Betbeder, Didier; Santos, Nuno C.. "The Shape, Dimension and Organisation of Maltodextrins Gel Fragments with and without Associated Phospholipids". In Light Scattering and Photon Correlation Spectroscopy, 173-187. Springer Netherlands, 1997.
    Published • 10.1007/978-94-011-5586-1_15
Conference abstract
  1. Sarmento, Maria J.; Kohutova, Petra; Carvalho, Filomena A.; Hof, Martin; Santos, Nuno C.. "Deciphering the role of nuclear envelope lipids in human healthy aging". Paper presented in EBSA Congress, Stockholm, 2023.
    Published
  2. Martins, Ana S.G.; Reis, S.D.; Ruxandra Baboi; Cortinhas, João; Domingues, M.M.; Santos, N.C.; Santos, Sofia Duque; Pêgo, Ana Paula; Moreno, P.M.D.. Corresponding author: Moreno, P.M.D.. "Nucleic acid-based nanostructures functionalized with neurotrophin-mimetic aptamer aiming at neuronal targeting". Paper presented in 31st Conference of the European Society for Biomaterials (ESB), Porto, 2021.
  3. Alves, Carla S.; Melo, Manuel N.; Franquelim, Henri G; Ferre, Rafael; Planas, Marta; Feliu, Lidia; Bardají, Eduard; et al. "Relation between Escherichia coli killing and charge neutralization by the antimicrobial peptides BP100 and pepR". Paper presented in Encontro Peptídico Ibérico / Iberian Peptide Meeting, Lisbon, 2010.
    Published
Conference paper
  1. Villarroel-Ortega, Jorge; Santos, N.C.; Correia, A.A.S.; Lemos, Luís; Venda Oliveira, P.J.. Corresponding author: Villarroel-Ortega, Jorge. "Efeito do teor da água, quantidade de ligantes e tempo de cura no comportamento mecânico de um solo mole estabilizado quimicamente". Paper presented in 17º Congresso Nacional de Geotecnia, Lisboa, 2021.
    Published
Conference poster
  1. Vieira, Tomás; Soares-Castro, Pedro; Gonçalves, Sónia; Santos, Nuno C.. Corresponding author: Vieira, Tomás. "EXPLORING SILVER NANOSTARS AS ANTIBACTERIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS". Paper presented in Biophysics Festival, 2024.
  2. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Circular RNAs in cardiovascular disease: Insights from a cardiac cell model". Paper presented in EMBO Workshop on The new cardiobiology, 2024.
  3. Lopes, Catarina S.; Carvalho, Filomena A.; Weinmüller, M.; Kessler, H.; Santos, Nuno C.. "avb3 integrin peptide inhibitors impact on fibrinogen-erythrocyte binding". Paper presented in XVIII Iberian Peptide Meeting, 2023.
  4. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Lourenço, Diogo M.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Into the Heart of Cardiac Diseases: Lessons from a Cardiac Model". Paper presented in 13th EMBO Young Scientists¿ Forum, 2023.
  5. Lopes, Catarina S.; Melo, Ryan; Duarte, António; Nabais, Sofia; Freitas, Teresa; Gaspar, Ana Rita; Fonseca, Ana Mara; et al. "Erythrocyte adhesion and biomechanics on carotid artery disease patients". Paper presented in 3rd Portuguese Young Biophysicists¿ Meeting, Biophysics Festival 2023, 2023.
  6. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina. "Sailing through the Surface to Unveil the Inner Workings of AC16 Cells: A Biophysical and Transcriptomic Expedition towards an Atrial Fibrillation cell model". Paper presented in XVI CAML · VI NeurULisboa PhD Students Meeting, 2023.
  7. Sarmento, Maria J.; Kohutova, Petra; Carvalho, Filomena A.; Hof, Martin; Santos, Nuno C.. "Unveiling the role of nuclear envelope lipids in human physiological aging". Paper presented in EMBO Young Scientists' Forum, 2023.
  8. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Vasco A. Conceição; Marta Gromicho; Santos, Nuno C.; de Carvalho, Mamede; Carvalho, Filomena A.. "Evaluation of morphological and elastic changes on erythrocytes and y' fibrinogen as possible predictors of survival in Amyotrophic Lateral Sclerosis". Paper presented in 8th International Iberian Biophysics congress, 2022.
  9. Sarmento, Maria J.; Pais do Amaral, Constança; Santos, Nuno C.. "Deciphering the lipid composition of the human nuclear envelope during healthy aging". Paper presented in Membrane Biophysics Meeting, 2022.
  10. M. Silva, Patrícia; da Silva, Inês V.; Sarmento, Maria J.; Filomena A. Carvalho; Soveral, Graça; Santos, Nuno C.. "AQP3 and AQP5 silencing promotes changes in cell-cell adhesion and biomechanical properties of pancreatic cancer cells". Paper presented in 20th IUPAB Congress, 45th Annual SBBf Meeting, and 50th Annual SBBq Meeting, 2021.
  11. Martins, Ana S.G.; Reis, S.D.; Ruxandra Baboi; Cortinhas, João; Domingues, M.M.; Santos, N.C.; Santos, S.D.; Pêgo, Ana Paula; Moreno, P.M.D.. Corresponding author: Moreno, P.M.D.. "Aptamer-functionalized tetrahedral DNA nanostructures aiming at neuronal targeting". Paper presented in 1st Symposium on Oligonucleotide Thecnologies & Therapeutics at Portugal, 2021.
  12. Martins, Ana S.G.; Santos, Sofia Duque; Marco M. Domingues; Santos, Nuno C.; Pêgo, Ana P.; Moreno, Pedro M. D.. Corresponding author: Moreno, Pedro M. D.. "Neuronal Targeted Nucleic-Acid Nanostructures aiming at Neurotherapies". Paper presented in World Biomaterials Congress 2020 (WBC 2020), 2020.
  13. Sabino, João C.; Sridhara, Sreerama C.; Abreu, Patrícia L.; Domingues, Marco M.; Santos, Nuno C.; Grosso, Ana Rita; de Almeida, Sérgio F.. "Epigenetic determinants of transcription-coupled genomic instability". Paper presented in Trends in Genome Integrity & Chromosome Dynamics, 2020.
  14. Silva, Patrícia; Peter Eaton; Santos, Nuno C.. "The interaction of viral fusion inhibitor lipopeptides with biomembranes is improved by PEG linker length". Paper presented in 4th Meeting of the College of Chemistry of ULisboa (4ECQUL), 2019.
  15. Lopes, Catarina S.; Guedes, Ana Filipa; Fonseca, Ana Catarina; Ferro, José M. ; Santos, Nuno C.; Carvalho, Filomena A.. "Fibrinogen-erythrocyte binding as a new cerebrovascular risk factor on stroke patients". Paper presented in XIII PhD Students Meeting,, 2019.
  16. L. Alves; F. A. Carvalho; C. Lopes; Maria I. L. Soares; Teresa M. V. D. Pinho e Melo; Santos, N.C.; O. V. Vieira. "Lysosomal dysfunction in vascular smooth muscle cells plays a role in atherosclerosis". Paper presented in Cell Dynamics: Organelle-Cytoskeleton Interface, 2019.
  17. Silva, Patrícia; Augusto, Marcelo T.; Marta C. Marques; Porotto, Matteo; Moscona, Anne; Santos, Nuno C.. "Biophysical characterization of lipid-tagged peptides as fusion inhibitors for respiratory viruses". Paper presented in 3rd Meeting of the CQUL (3ECQUL), 2018.
  18. Lopes, Catarina S.; Pronto-Laborinho, Ana Catarina; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in XII PhD Students Meeting, 2018.
  19. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in Bioimaging 2016, 5th International Symposium in Applied Bioimaging – Disease in Focus, 2016.
  20. Lopes, Catarina S.; Guedes, Ana Filipa; Nogueira, J. B.; Moreira, C.; Carvalho, Filomena A.; Santos, Nuno C.. "Erythrocyte-erythrocyte adhesion promoted by fibrinogen in Essential Arterial Hypertension patients". Paper presented in 5th International Iberian Biophysics Congress, 2016.
Journal article
  1. Marlon H. Cardoso; Cesar de la Fuente-Nunez; Nuno C. Santos; Michael A. Zasloff; Octávio L. Franco. "Influence of antimicrobial peptides on the bacterial membrane curvature and vice versa". Trends in Microbiology (2024): https://doi.org/10.1016/j.tim.2024.04.012.
    10.1016/j.tim.2024.04.012
  2. Liana Costa Pereira Vilas Boas; Danieli Fernanda Buccini; Rhayfa Lorrayne Araújo Berlanda; Bruno de Paula Oliveira Santos; Mariana Rocha Maximiano; Luciano Morais Lião; Sónia Gonçalves; Nuno C. Santos; Octávio Luiz Franco. "Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1". Viruses (2024): https://doi.org/10.3390/v16060948.
    10.3390/v16060948
  3. Martins, Ana S. G.; Reis, Sara D.; Benson, Erik; Domingues, Marco M.; Cortinhas, João; Vidal Silva, Joana A.; Santos, Sofia D.; et al. "Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures". Small (2024): http://dx.doi.org/10.1002/smll.202309140.
    10.1002/smll.202309140
  4. Artur J. M. Valente; Nuno C. Santos; Maria João Moreno. "State-of-the-Art Macromolecules in Portugal". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25010620.
    10.3390/ijms25010620
  5. Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, Nuno; Atalaia-Barbacena, Henrique; et al. "A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease". (2024): http://hdl.handle.net/10362/173840.
    https://doi.org/10.1016/j.ymthe.2024.08.022
  6. Catarina S. Lopes; Ana Catarina Pronto-Laborinho; Vasco A. Conceição; Teresa Freitas; Gonçalo L. Matias; Marta Gromicho; Nuno C. Santos; Mamede de Carvalho; Filomena A. Carvalho. "Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients". BioFactors (2023): https://doi.org/10.1002/biof.2030.
    10.1002/biof.2030
  7. Costa, Igor S. D.; Junot, Tiago; Silva, Fernanda L.; Felix, Wanessa; Cardozo Fh, José L.; Pereira de Araujo, Antonio F.; Pais do Amaral, Constança; et al. "Occurrence and evolutionary conservation analysis of a-helical cationic amphiphilic segments in the human proteome". The FEBS Journal (2023): http://dx.doi.org/10.1111/febs.16997.
    Published • 10.1111/febs.16997
  8. Sónia Gonçalves; Nuno C. Santos. "Membrane–Peptide Interactions: From Basics to Current Applications 2.0". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087202.
    10.3390/ijms24087202
  9. Lopes, Catarina S.; Curty, Juliana; Carvalho, Filomena Almeida; Hernández-Machado, A.; Kinoshita, Koji; Santos, Nuno C.; Travasso, Rui D. M.; et al. "A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion". Communications Biology (2023): http://hdl.handle.net/10451/56478.
    10.1038/s42003-023-04560-4
  10. Cerqueira, Miguel A.; Leite, Ana C. C. O.; Tomás, Ana L.; Reichel, Anna; Silva, Patrícia M.; Santos, Nuno C.; Michelin, Michele; et al. "Edible alginate-based films with anti-SARS-CoV-2 activity". (2023): https://hdl.handle.net/1822/83398.
    10.1016/j.fm.2023.104251
  11. Makowski, Marcin; Almendro-Vedia, Víctor G.; Domingues, Marco; Franco, Octavio L.; López-Montero, Iván; Melo, Manuel N.; Santos, Nuno C.. "Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering". (2023): http://hdl.handle.net/10451/58716.
    10.1016/j.isci.2023.107004
  12. Carvalho, Maria; Medeiros, Márcia M.; Morais, Inês; Lopes, Catarina S.; Balau, Ana; Santos, Nuno C.; Carvalho, Filomena A.; et al. "2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane". International Journal of Molecular Sciences (2023): http://hdl.handle.net/10362/149210.
    https://doi.org/10.3390/ijms24021336
  13. Boon, Priscilla L. S.; Silva Martins, Ana; Lim, Xin Ni; Enguita, Francisco J.; Santos, Nuno C.; Bond, Peter J.; Wan, Yue; et al. "Dengue virus capsid protein facilitates genome compaction and packaging". International Journal of Molecular Sciences (2023): http://hdl.handle.net/10451/57722.
    10.3390/ijms24098158
  14. Fonseca Gomes, J; Rodrigues, Tiago M; Vaz, Sandra H; Ramalho, R M; Vicente Miranda, Hugo; Tanqueiro, S; Miranda-Lourenço, C; et al. "A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer's Disease (Submitted)". (2023):
    Submitted
  15. Ivo C. Martins; Rafaela C. Ricardo; Nuno C. Santos. "Dengue, West Nile, and Zika Viruses: Potential Novel Antiviral Biologics Drugs Currently at Discovery and Preclinical Development Stages". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112535.
    10.3390/pharmaceutics14112535
  16. Sónia Gonçalves; Ivo C. Martins; Nuno C. Santos. "Nanoparticle-peptide conjugates for bacterial detection and neutralization: Potential applications in diagnostics and therapy". WIREs Nanomedicine and Nanobiotechnology (2022): https://doi.org/10.1002/wnan.1819.
    10.1002/wnan.1819
  17. Maïssa Dardouri; Ana Bettencourt; Victor Martin; Filomena A. Carvalho; Bruno Colaço; Adelina Gama; Madeleine Ramstedt; et al. "Assuring the Biofunctionalization of Silicone Covalently Bonded to Rhamnolipids: Antibiofilm Activity and Biocompatibility". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091836.
    10.3390/pharmaceutics14091836
  18. Patrícia M. Silva; Inês Vieira da Silva; Maria J. Sarmento; Silva, Í. C.; Filomena A. Carvalho; Graça Soveral; Nuno C. Santos. "Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties". Cells (2022): https://www.mdpi.com/2073-4409/11/8/1308.
    10.3390/cells11081308
  19. Liliana S. Alves; André R. A. Marques; Nuno Padrão; Filomena A. Carvalho; José Ramalho; Catarina S. Lopes; Maria I. L. Soares; et al. "Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis". Journal of Cell Science (2022): https://doi.org/10.1242/jcs.254631.
    10.1242/jcs.254631
  20. Plácido, A.; do Pais do Amaral, C.; Teixeira, C.; Nogueira, A.; Brango-Vanegas, J.; Alves Barbosa, E.; C. Moreira, D.; et al. "Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi". Journal of Cellular and Molecular Medicine 26 10 (2022): 2793-2807. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128779284&partnerID=MN8TOARS.
    10.1111/jcmm.17292
  21. Correia, Gil; Rodrigues, Luís; Afonso, Mariana; Mota, Marta; Oliveira, Joana; Soares, Rui; Tomás, Ana Luísa; et al. "SARS-CoV-2 air and surface contamination in residential settings". (2022): http://hdl.handle.net/10451/54944.
    10.1038/s41598-022-22679-y
  22. Barbosa, Joana C.; Gonçalves, Sónia; Makowski, Marcin; Silva, Ítala Cristine; Caetano, Tânia; Schneider, Tanja; Mösker, Eva; et al. "Insights into the mode of action of the two-peptide lantibiotic lichenicidin". (2022): http://hdl.handle.net/10451/50726.
    10.1016/j.colsurfb.2021.112308
  23. Tomás, Ana Luísa; Reichel, Anna; Silva, Patrícia M.; Silva, Pedro G.; Pinto, João; Calado, Inês; Campos, Joana; et al. "UV-C irradiation-based inactivation of SARS-CoV-2 in contaminated porous and non-porous surfaces". (2022): http://hdl.handle.net/10451/54423.
    10.1016/j.jphotobiol.2022.112531
  24. Marques, Marta C.; Lousa, Diana; Silva, Patrícia M.; Faustino, André F.; Soares, Cláudio M.; Santos, Nuno C.; Marta C. Marques; et al. "The importance of lipid conjugation on anti-fusion peptides against Nipah virus". Biomedicines (2022): http://hdl.handle.net/10451/52076.
    10.3390/biomedicines10030703
  25. Barbosa, Joana C; Silva, Ítala C; Caetano, Tânia; Mösker, Eva; Seidel, Maria; Lourenço, Joana; Süssmuth, Roderich D; et al. "Assessing the potential of the two-peptide lantibiotic lichenicidin as a new generation antimicrobial". World Journal of Microbiology and Biotechnology 38 1 (2022): http://hdl.handle.net/10773/43432.
    10.1007/s11274-021-03196-y
  26. Tânia B. Cruz; Filomena A. Carvalho; Paulo N. Matafome; Raquel A. Soares; Nuno C. Santos; Rui D. Travasso; Maria J. Oliveira. "Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features". Biomedicines (2021): https://doi.org/10.3390/biomedicines10010057.
    10.3390/biomedicines10010057
  27. Borges-Araújo, Luís; Domingues, Marco M.; Fedorov, Alexander; Santos, Nuno C.; Melo, Manuel N.; Fernandes, Fábio. "Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains". Communications Chemistry 4 1 (2021): http://dx.doi.org/10.1038/s42004-021-00603-1.
    Published • 10.1038/s42004-021-00603-1
  28. Dardouri, Maïssa; Bettencourt, Ana; Martin, Victor; Carvalho, Filomena A.; Santos, Catarina; Monge, Nuno; Santos, Nuno C.; et al. "Using plasma-mediated covalent functionalization of rhamnolipids on polydimethylsiloxane towards the antimicrobial improvement of catheter surfaces". Materials Science and Engineering: C (2021): 112563. http://dx.doi.org/10.1016/j.msec.2021.112563.
    Accepted • 10.1016/j.msec.2021.112563
  29. Pronto-Laborinho, Ana Catarina; Lopes, Catarina S.; Conceição, Vasco A.; Gromicho, Marta; Santos, Nuno C.; de Carvalho, Mamede; Carvalho, Filomena A.. "¿' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis". Frontiers in Cardiovascular Medicine 8 (2021): http://dx.doi.org/10.3389/fcvm.2021.715842.
    10.3389/fcvm.2021.715842
  30. Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria Silva; et al. "Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (Bothrops atrox)". Journal of Natural Products 84 6 (2021): 1787-1798. http://dx.doi.org/10.1021/acs.jnatprod.1c00153.
    Published • 10.1021/acs.jnatprod.1c00153
  31. Pronto-Laborinho, Ana Catarina; Lopes, Catarina S.; Santos, Nuno C.; Carvalho, Filomena A.; de Carvalho, Mamede. "Molecular biomarkers associated with respiratory insufficiency in amyotrophic lateral sclerosis". Annals of Medicine 53 sup1 (2021): S4-S5. http://dx.doi.org/10.1080/07853890.2021.1894009.
    10.1080/07853890.2021.1894009
  32. Marco M. Domingues; Bárbara Gomes; Axel Hollmann; Nuno C. Santos; Domingues, Marco; Gomes, Bárbara; Hollmann, Axel; Santos, Nuno C.. "25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties". International Journal of Molecular Sciences 22 5 (2021): 2574-2574. https://doi.org/10.3390/ijms22052574.
    10.3390/ijms22052574
  33. De Falco, Louis; Silva, Nelly; Santos, Nuno C.; Huber, Roland G.; Martins, Ivo C.; Louis De Falco; Nelly M. Silva; et al. "The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization". Cells (2021): http://hdl.handle.net/10451/49529.
    10.3390/cells10030642
  34. Silva, Patrícia M.; Augusto, Marcelo T.; Porotto, Matteo; Santos, Nuno C.. "The pH-sensitive action of cholesterol-conjugated peptide inhibitors of influenza virus". (2021): http://hdl.handle.net/10451/49550.
    10.1016/j.bbamem.2021.183762
  35. Carvalho, Patricia; Makowski, Marcin; Domingues, Marco; Martins, Ivo C.; Santos, Nuno C.. "Lipid membrane-based therapeutics and diagnostics". (2021): http://hdl.handle.net/10451/47441.
    10.1016/j.abb.2021.108858
  36. Felício, Mário R.; Silveira, Gislaine G. O. S.; Oshiro, Karen G. N.; Meneguetti, Beatriz T.; Franco, Octávio L.; Santos, Nuno C.; Gonçalves, Sónia. "Polyalanine peptide variations may have different mechanisms of action against multidrug-resistant bactrial pathogens". (2021): http://hdl.handle.net/10451/46205.
    10.1093/jac/dkaa560
  37. Pronto-Laborinho, A.C.; Lopes, C.S.; Conceição, V.A.; Gromicho, M.; Santos, N.C.; de Carvalho, M.; Carvalho, F.A.. "Corrigendum: ¿' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis (Frontiers in Cardiovascular Medicine, (2021), 8, (715842), 10.3389/fcvm.2021.715842)". Frontiers in Cardiovascular Medicine 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85170649722&partnerID=MN8TOARS.
    10.3389/fcvm.2021.800151
  38. Nelly M. Silva; Nuno C. Santos; Ivo C. Martins; Silva, Nelly; Santos, Nuno C.; Martins, Ivo C.. "Dengue and Zika Viruses: Epidemiological History, Potential Therapies, and Promising Vaccines". Tropical Medicine and Infectious Disease 5 4 (2020): 150-150. https://doi.org/10.3390/tropicalmed5040150.
    10.3390/tropicalmed5040150
  39. Martins, Ivo C.; Santos, Nuno C.. "Intrinsically disordered protein domains in flavivirus infection". Archives of Biochemistry and Biophysics 683 (2020): 108298. http://dx.doi.org/10.1016/j.abb.2020.108298.
    10.1016/j.abb.2020.108298
  40. Makowski, Marcin; Felício, Mário Romão; Fensterseifer, Isabel C M; Franco, Octávio L; Santos, Nuno C.; Gonçalves, Sónia; Marcin Makowski; et al. "EcDBS1R4, an antimicrobial peptide effective against Escherichia coli with in vitro fusogenic ability". International Journal of Molecular Sciences 21 23 (2020): 9104-9104. http://hdl.handle.net/10451/47250.
    10.3390/ijms21239104
  41. Aguiar, Francisca Lidiane Linhares de; Santos, Nuno C.; de Paula Cavalcante, Carolina Sidrim; Andreu, David; Baptista, Gandhi Radis; Gonçalves, Sónia; Francisca Lidiane Linhares de Aguiar; et al. "Antibiofilm activity on Candida albicans and mechanism of action on biomembrane models of the antimicrobial peptide Ctn(15–34)". International Journal of Molecular Sciences (2020): http://hdl.handle.net/10451/47276.
    10.3390/ijms21218339
  42. Maturana, Patricia; Gonçalves, Sónia; Martinez, Melina; Espeche, Juan C.; Santos, Nuno C.; Semorile, Liliana; Maffia, Paulo C.; Hollmann, Axel. "Interactions of “de novo” designed peptides with bacterial membranes: implications in the antimicrobial activity". (2020): http://hdl.handle.net/10451/49712.
    10.1016/j.bbamem.2020.183443
  43. Marcin Makowski; Ítala C. Silva; Constança Pais do Amaral; Sónia Gonçalves; Nuno C. Santos. "Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11110588.
    10.3390/pharmaceutics11110588
  44. Bárbara Gomes; Giusepinna Sanna; Silvia Madeddu; Axel Hollmann; Nuno C. Santos. "Combining 25-Hydroxycholesterol with an HIV Fusion Inhibitor Peptide: Interaction with Biomembrane Model Systems and Human Blood Cells". ACS Infectious Diseases (2019): https://doi.org/10.1021/acsinfecdis.8b00321.
    10.1021/acsinfecdis.8b00321
  45. Irazazabal, L.N.; Porto, W.F.; Fensterseifer, I.C.M.; Alves, E.S.F.; Matos, C.O.; Menezes, A.C.S.; Felício, M.R.; et al. "Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide". Biochimica et Biophysica Acta - Biomembranes 1861 1 (2019): 178-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054381490&partnerID=MN8TOARS.
    10.1016/j.bbamem.2018.08.001
  46. Ana Filipa Guedes; Carlos Moreira; José B. Nogueira; Nuno C. Santos; Filomena A. Carvalho; Guedes, Ana Filipa; Moreira, Carlos; et al. "Fibrinogen–erythrocyte binding and hemorheology measurements in the assessment of essential arterial hypertension patients". Nanoscale (2019): https://doi.org/10.1039/C8NR04398A.
    10.1039/C8NR04398A
  47. Faustino, André F.; Barbosa, Glauce M.; Silva, Micael; Castanho, Miguel A. R. B.; Da Poian, Andrea T.; Cabrita, Eurico J.; Santos, Nuno C.; et al. "Fast NMR method to probe solvent accessibility and disordered regions in proteins". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-018-37599-z.
    10.1038/s41598-018-37599-z,title
  48. de Barros, Elizângela; Gonçalves, Regina M.; Cardoso, Marlon H.; Santos, Nuno C.; Franco, Octávio L.; Cândido, Elizabete S.. "Snake venom cathelicidins as natural antimicrobial peptides". Frontiers in Pharmacology 10 (2019): http://hdl.handle.net/10451/52341.
    10.3389/fphar.2019.01415
  49. Amaral, Virginia Sara Grancieri; Fernandes, Caroline Mota; Felício, Mário Romão; Valle, Aline Sol; Quintana, Paula G.; Almeida, Caroline Correa; Barreto-Bergter, Eliana; et al. "Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol". (2019): http://hdl.handle.net/10451/37917.
    10.1016/j.bbamem.2018.12.020
  50. Faustino, André F.; Silva Martins, Ana; Karguth, Nina; Artilheiro, Vanessa; Enguita, Francisco J.; Ricardo, Joana; Santos, Nuno C.; Martins, Ivo C.. "Structural and functional properties of the capsid protein of Dengue and related Flavivirus". (2019): http://hdl.handle.net/10451/52589.
    10.3390/ijms20163870
  51. Martins, Ana S.; Carvalho, Filomena Almeida; Faustino, André F.; Martins, Ivo C.; Santos, Nuno C.. "West Nile virus capsid protein interacts with biologically relevant host lipid systems". (2019): http://hdl.handle.net/10451/37841.
    10.3389/fcimb.2019.00008
  52. Meneguetti, Beatriz T.; Cardoso, Marlon H.; Ribeiro, Camila F.A.; Felício, Mário Romão; Pinto, Ingrid B.; Santos, Nuno C.; Carvalho, Cristiano M.E.; et al. "Neuropeptide receptors as potential pharmacological targets for obesity". Pharmacology and Therapeutics (2019): http://hdl.handle.net/10451/54316.
    10.1016/j.pharmthera.2018.11.002
  53. Fensterseifer, Isabel C. M.; Felício, Mário Romão; Alves, Eliane S. F.; Cardoso, Marlon H.; Torres, Marcelo D. T.; Matos, Carolina O.; Silva, Osmar N.; et al. "Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria". (2019): http://hdl.handle.net/10451/52958.
    10.1016/j.bbamem.2019.03.016
  54. Carvalho, F.A.; Guedes, A.F.; Duval, C.; Macrae, F.L.; Swithenbank, L.; Farrell, D.H.; Ariëns, R.A.S.; et al. "The95RGD97sequence on the Aa Chain of fibrinogen is essential for binding to its erythrocyte receptor". International Journal of Nanomedicine 13 (2018): 1985-1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045300534&partnerID=MN8TOARS.
    10.2147/IJN.S154523
  55. Figueira, T.N.; Augusto, M.T.; Rybkina, K.; Stelitano, D.; Noval, M.G.; Harder, O.E.; Veiga, A.S.; et al. "Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane". Bioconjugate Chemistry 29 10 (2018): 3362-3376. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053669384&partnerID=MN8TOARS.
    10.1021/acs.bioconjchem.8b00527
  56. Guedes, A.F.; Carvalho, F.A.; Domingues, M.M.; Macrae, F.L.; McPherson, H.R.; Sabban, A.; Martins, I.C.; et al. "Impact of ¿'¿' fibrinogen interaction with red blood cells on fibrin clots". Nanomedicine 13 19 (2018): 2491-2505. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055917620&partnerID=MN8TOARS.
    10.2217/nnm-2018-0136
  57. Jeremias, H.F.; Lousa, D.; Hollmann, A.; Coelho, A.C.; Baltazar, C.S.; Seixas, J.D.; Marques, A.R.; et al. "Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods". PLoS ONE 13 9 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053913626&partnerID=MN8TOARS.
    10.1371/journal.pone.0204624
  58. Gomes, B.; Augusto, M.T.; Felício, M.R.; Hollmann, A.; Franco, O.L.; Gonçalves, S.; Santos, N.C.; et al. "Designing improved active peptides for therapeutic approaches against infectious diseases". Biotechnology Advances 36 2 (2018): 415-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042940089&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2018.01.004
  59. Martins, A.S.; Martins, I.C.; Santos, N.C.; Martins, Ana S.; Martins, Ivo C.; Santos, Nuno C.. "Methods for lipid droplet biophysical characterization in flaviviridae infections". Frontiers in Microbiology 9 AUG (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85051847327&partnerID=MN8TOARS.
    10.3389/fmicb.2018.01951
  60. Ribeiro, A.S.; Nobre, A.R.; Mendes, N.; Almeida, J.; Vieira, A.F.; Sousa, B.; Carvalho, F.A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell communication and signaling : CCS 16 1 (2018): 75-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056432555&partnerID=MN8TOARS.
    10.1186/s12964-018-0286-2
  61. Bravo-Ferrada, B.M.; Gonçalves, S.; Semorile, L.; Santos, N.C.; Brizuela, N.S.; Elizabeth Tymczyszyn, E.; Hollmann, A.; et al. "Cell surface damage and morphological changes in Oenococcus oeni after freeze-drying and incubation in synthetic wine". Cryobiology 82 (2018): 15-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046809540&partnerID=MN8TOARS.
    10.1016/j.cryobiol.2018.04.014
  62. Guedes, A.F.; Carvalho, F.A.; Domingues, M.M.; Macrae, F.L.; McPherson, H.R.; Santos, N.C.; Ari¿ns, R.A.S.; et al. "Sensing adhesion forces between erythrocytes and ¿’ fibrinogen, modulating fibrin clot architecture and function". Nanomedicine: Nanotechnology, Biology, and Medicine 14 3 (2018): 909-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042410370&partnerID=MN8TOARS.
    10.1016/j.nano.2018.01.006
  63. Gomes, B.; Gonçalves, S.; Disalvo, A.; Hollmann, A.; Santos, N.C.; Gomes, Bárbara; Abreu, Sónia Gonçalves; et al. "Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition". Biochimica et Biophysica Acta - Biomembranes 1860 5 (2018): 1171-1178. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042308900&partnerID=MN8TOARS.
    10.1016/j.bbamem.2018.02.001
  64. Hollmann, A.; Delfederico, L.; Santos, N.C.; Disalvo, E.A.; Semorile, L.; Hollmann, Axel; Delfederico, Lucrecia; et al. "Interaction of S-layer proteins of Lactobacillus kefir with model membranes and cells". Journal of Liposome Research 28 2 (2018): 117-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011807608&partnerID=MN8TOARS.
    10.1080/08982104.2017.1281950
  65. Carvalho, Patricia; Felício, Mário Romão; Santos, Nuno C.; Abreu, Sónia Gonçalves; Domingues, Marco; Carvalho, P.M.; Felício, M.R.; et al. "Application of light scattering techniques to nanoparticle characterization and development". Frontiers in Chemistry 6 (2018): http://hdl.handle.net/10451/37852.
    10.3389/fchem.2018.00237
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    10.1016/j.bbamem.2012.06.014
  124. Ribeiro, M.M.B.; Domingues, M.M.; Freire, J.M.; Santos, N.C.; Castanho, M.A.R.B.. "Translocating the blood-brain barrier using electrostatics". Frontiers in Cellular Neuroscience SEPTEMBER (2012): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867062087&partnerID=MN8TOARS.
    10.3389/fncel.2012.00044
  125. Martins, A.P.; Lopes, P.A.; Madeira, M.S.; Martins, S.V.; Santos, N.C.; Moura, T.F.; Prates, J.A.M.; Soveral, G.. "Differences in lipid deposition and adipose membrane biophysical properties from lean and obese pigs under dietary protein restriction". Biochemical and Biophysical Research Communications 423 1 (2012): 170-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862693223&partnerID=MN8TOARS.
    10.1016/j.bbrc.2012.05.108
  126. Martins, I.C.; Gomes-Neto, F.; Faustino, A.F.; Carvalho, F.A.; Carneiro, F.A.; Bozza, P.T.; Mohana-Borges, R.; et al. "The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif". Biochemical Journal 444 3 (2012): 405-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862165670&partnerID=MN8TOARS.
    10.1042/BJ20112219
  127. Domingues, M.M.; Inácio, R.G.; Raimundo, J.M.; Martins, M.; Castanho, M.A.; Santos, N.C.. "Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems.". Biopolymers 98 4 (2012): 338-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872029556&partnerID=MN8TOARS.
  128. Gomes, I.; Feio, M.J.; Santos, N.C.; Eaton, P.; Serro, A.P.; Saramago, B.; Pereira, E.; Franco, R.. "Controlled adsorption of cytochrome c to nanostructured gold surfaces". Journal of Nanoparticle Research 14 12 (2012): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869874481&partnerID=MN8TOARS.
    10.1007/s11051-012-1321-7
  129. Gonçalves, S.; Abade, J.; Teixeira, A.; Santos, N.C.. "Lipid composition is a determinant for human defensin HNP1 selectivity.". Biopolymers 98 4 (2012): 313-321. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872050769&partnerID=MN8TOARS.
  130. Franco, O.L.; Santos, N.C.. "Peptides from agribusiness to human health.". Biopolymers 98 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872027202&partnerID=MN8TOARS.
  131. Domingues, M.M.; Santos, N.C.; Castanho, M.A.R.B.. "Antimicrobial peptide rBPI21: A translational overview from bench to clinical studies". Current Protein and Peptide Science 13 7 (2012): 611-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874879695&partnerID=MN8TOARS.
    10.2174/138920312804142101
  132. Padilla-Parra, S.; Matos, P.M.; Kondo, N.; Marin, M.; Santos, N.C.; Melikyan, G.B.. "Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes". Proceedings of the National Academy of Sciences of the United States of America 109 43 (2012): 17627-17632. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867907917&partnerID=MN8TOARS.
    10.1073/pnas.1211714109
  133. Eaton, P.; Zuzarte-Luis, V.; Mota, M.M.; Santos, N.C.; Prudêncio, M.. "Infection by Plasmodium changes shape and stiffness of hepatic cells". Nanomedicine: Nanotechnology, Biology, and Medicine 8 1 (2012): 17-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855332785&partnerID=MN8TOARS.
    10.1016/j.nano.2011.10.004
  134. Ascenso, A.; Guedes, R.; Bernardino, R.; Diogo, H.; Carvalho, F.A.; Santos, N.C.; Silva, A.M.; Marques, H.C.. "Complexation and full characterization of the tretinoin and dimethyl-ß-cyclodextrin complex.". AAPS PharmSciTech 12 2 (2011): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861168025&partnerID=MN8TOARS.
    10.1208/s12249-011-9612-3
  135. Freire, J.M.; Domingues, M.M.; Matos, J.; Melo, M.N.; Veiga, A.S.; Santos, N.C.; Castanho, M.A.R.B.. "Using zeta-potential measurements to quantify peptide partition to lipid membranes". European Biophysics Journal 40 4 (2011): 481-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956016236&partnerID=MN8TOARS.
    10.1007/s00249-010-0661-4
  136. Carvalho, F.A.; de Oliveira, S.; Freitas, T.; Gonçalves, S.; Santos, N.C.. "Variations on fibrinogen-erythrocyte interactions during cell aging". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953147017&partnerID=MN8TOARS.
    10.1371/journal.pone.0018167
  137. Franquelim, H.G.; Chiantia, S.; Veiga, A.S.; Santos, N.C.; Schwille, P.; Castanho, M.A.R.B.. "Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes". AIDS 25 4 (2011): 419-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951514918&partnerID=MN8TOARS.
    10.1097/QAD.0b013e328342ff11
  138. Castanho, M.; Santos, N.C.; Santos, Nuno C.. "Peptide Drug Discovery and Development: Translational Research in Academia and Industry". Peptide Drug Discovery and Development: Translational Research in Academia and Industry (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869033333&partnerID=MN8TOARS.
    10.1002/9783527636730
  139. Martins, A.P.; Lopes, P.A.; Costa, A.S.H.; Martins, S.V.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability". Animal 5 12 (2011): 1949-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160624&partnerID=MN8TOARS.
    10.1017/S1751731111001091
  140. Rodrigues, M.; De La Torre, B.G.; Rádis-Baptista, G.; Santos, N.C.; Andreu, D.. "Efficient cellular delivery of ß-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides". Bioconjugate Chemistry 22 11 (2011): 2339-2344. http://www.scopus.com/inward/record.url?eid=2-s2.0-81255189096&partnerID=MN8TOARS.
    10.1021/bc200421z
  141. Franquelim, H.G.; De-Sousa, F.F.; Veiga, A.S.; Santos, N.C.; Castanho, M.A.R.B.. "Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide". Soft Matter 7 23 (2011): 11089-11092. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355123272&partnerID=MN8TOARS.
    10.1039/c1sm06553j
  142. Franquelim, H.G.; Veiga, A.S.; Weissmüller, G.; Santos, N.C.; Castanho, M.A.R.B.. "Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes". Biochimica et Biophysica Acta - Biomembranes 1798 6 (2010): 1234-1243. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952551415&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.02.010
  143. Santos, N.C.. "In and out - Biochemical and biophysical mechanisms of viral fusion and assembly". TheScientificWorldJournal 10 (2010): 419-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951761669&partnerID=MN8TOARS.
    10.1100/tsw.2010.53
  144. Santos, N.C.; Martins E Silva, J.; Freitas, T.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Blood cell membrane fluidity and intracellular Ca2+changes in antiretroviral-naïve and -treated HIV-1-infected patients". TheScientificWorldJournal 10 (2010): 350-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749327970&partnerID=MN8TOARS.
    10.1100/tsw.2010.34
  145. Alves, C.S.; Melo, M.N.; Franquelim, H.G.; Ferre, R.; Planas, M.; Feliu, L.; Bardají, E.; et al. "Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR". Journal of Biological Chemistry 285 36 (2010): 27536-27544. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956238793&partnerID=MN8TOARS.
    10.1074/jbc.M110.130955
  146. Matos, P.M.; Castanho, M.A.R.B.; Santos, N.C.. "HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes". PLoS ONE 5 3 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956502249&partnerID=MN8TOARS.
    10.1371/journal.pone.0009830
  147. Matos, P.M.; Franquelim, H.G.; Castanho, M.A.R.B.; Santos, N.C.. "Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies". Biochimica et Biophysica Acta - Biomembranes 1798 11 (2010): 1999-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953139417&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.07.012
  148. Santiago, P.S.; Carvalho, J.W.P.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Thermal stability of extracellular hemoglobin of Glossoscolex paulistus: Determination of activation parameters by optical spectroscopic and differential scanning calorimetric studies". Biophysical Chemistry 152 1-3 (2010): 128-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149282480&partnerID=MN8TOARS.
    10.1016/j.bpc.2010.08.010
  149. Ribeiro, M.M.B.; Melo, M.N.; Serrano, I.D.; Santos, N.C.; Castanho, M.A.R.B.. "Drug-lipid interaction evaluation: Why a 19th century solution?". Trends in Pharmacological Sciences 31 10 (2010): 449-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956909526&partnerID=MN8TOARS.
    10.1016/j.tips.2010.06.007
  150. Matos, P.M.; Freitas, T.; Castanho, M.A.R.B.; Santos, N.C.. "The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide". Biochemical and Biophysical Research Communications 403 3-4 (2010): 270-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650172669&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.11.013
  151. Carvalho, F.A.; Connell, S.; Miltenberger-Miltenyi, G.; Pereira, S.V.; Tavares, A.; Ariëns, R.A.S.; Santos, N.C.. "Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes". ACS Nano 4 8 (2010): 4609-4620. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650138418&partnerID=MN8TOARS.
    10.1021/nn1009648
  152. Martins, A.P.; Lopes, P.A.; Martins, S.V.; Madeira, A.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Conjugated linoleic acid reduces permeability and fluidity of adipose plasma membranes from obese Zucker rats". Biochemical and Biophysical Research Communications 398 2 (2010): 199-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955057876&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.06.059
  153. Santiago, P.S.; Carvalho, F.A.O.; Domingues, M.M.; Carvalho, J.W.P.; Santos, N.C.; Tabak, M.. "Isoelectric point determination for Glossoscolex paulistus extracellular hemoglobin: Oligomeric stability in acidic pH and relevance to protein-surfactant interactions". Langmuir 26 12 (2010): 9794-9801. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956081477&partnerID=MN8TOARS.
    10.1021/la100060p
  154. Domingues, M.M.; Lopes, S.C.D.N.; Santos, N.C.; Quintas, A.; Castanho, M.A.R.B.. "Fold-Unfold transitions in the selectivity and mechanism of action of the N-Terminal fragment of the bactericidal/permeability-increasing protein (rBPI21)". Biophysical Journal 96 3 (2009): 987-996. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549096250&partnerID=MN8TOARS.
    10.1016/j.bpj.2008.10.044
  155. Domingues, M.M.; Castanho, M.A.R.B.; Santos, N.C.; Domingues, Marco; Castanho, Miguel A. R. B.; Santos, Nuno C.. "rBPI21 promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes". PLoS ONE 4 12 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949517357&partnerID=MN8TOARS.
    10.1371/journal.pone.0008385
  156. Vieira, C.R.; Castanho, M.; Saldanha, C.; Santos, N.C.. "Enfuvirtide effects on human erythrocytes and lymphocytes functional properties". Journal of Peptide Science 14 4 (2008): 448-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149163387&partnerID=MN8TOARS.
    10.1002/psc.1006
  157. Matos, P.M.; Gonçalves, S.; Santos, N.C.. "Interaction of peptides with biomembranes assessed by potential-sensitive fluorescent probes". Journal of Peptide Science 14 4 (2008): 407-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149117742&partnerID=MN8TOARS.
    10.1002/psc.1005
  158. Domingues, M.M.; Santiago, P.S.; Castanho, M.A.R.B.; Santos, N.C.. "What can light scattering spectroscopy do for membrane-active peptide studies?". Journal of Peptide Science 14 4 (2008): 394-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149116252&partnerID=MN8TOARS.
    10.1002/psc.1007
  159. Santiago, P.S.; Moura, F.; Moreira, L.M.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Dynamic light scattering and optical absorption spectroscopy study of pH and temperature stabilities of the extracellular hemoglobin of glossoscolex paulistus". Biophysical Journal 94 6 (2008): 2228-2240. http://www.scopus.com/inward/record.url?eid=2-s2.0-44049099950&partnerID=MN8TOARS.
    10.1529/biophysj.107.116780
  160. Gomes, I.; Santos, N.C.; Oliveira, L.M.-A.; Quintas, A.; Eaton, P.; Pereira, E.; Franco, R.. "Probing surface properties of cytochrome c at Au bionanoconjugates". Journal of Physical Chemistry C 112 42 (2008): 16340-16347. http://www.scopus.com/inward/record.url?eid=2-s2.0-55649094472&partnerID=MN8TOARS.
    10.1021/jp804766v
  161. Franquelim, H.G.; Loura, L.M.S.; Santos, N.C.; Castanho, M.A.R.B.. "Sifuvirtide screens rigid membrane surfaces. Establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides". Journal of the American Chemical Society 130 19 (2008): 6215-6223. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249117737&partnerID=MN8TOARS.
    10.1021/ja711247n
  162. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fluorescence spectroscopy evaluation of fibrinogen-ß-estradiol binding". Journal of Photochemistry and Photobiology B: Biology 86 2 (2007): 170-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845567319&partnerID=MN8TOARS.
    10.1016/j.jphotobiol.2006.09.001
  163. Veiga, S.; Yuan, Y.; Li, X.; Santos, N.C.; Liu, G.; Castanho, M.A.R.B.. "Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions". Biochimica et Biophysica Acta - General Subjects 1760 1 (2006): 55-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-29044440663&partnerID=MN8TOARS.
    10.1016/j.bbagen.2005.10.001
  164. Martins-Silva, J.; Santos, N.C.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Changes in blood cell membrane properties in HIV type-1-infected patients". AIDS Research and Human Retroviruses 22 9 (2006): 849-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751026185&partnerID=MN8TOARS.
    10.1089/aid.2006.22.849
  165. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fibrinogen-ß-estradiol binding studied by fluorescence spectroscopy: Denaturation and pH effects". Journal of Fluorescence 16 2 (2006): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646711479&partnerID=MN8TOARS.
    10.1007/s10895-005-0051-y
  166. Veiga, A.S.; Santos, N.C.; Castanho, M.A.. "An insight on the leading HIV entry inhibitors.". Recent patents on anti-infective drug discovery 1 1 (2006): 67-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-39049093808&partnerID=MN8TOARS.
    10.2174/157489106775244046
  167. Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Gramicidin D and dithiothreitol effects on erythrocyte exovesiculation". Cell Biochemistry and Biophysics 43 3 (2005): 419-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144489727&partnerID=MN8TOARS.
    10.1385/CBB:43:3:419
  168. Santos, Nuno C.; Martins e Silva, João; Saldanha, Carlota; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "PTEN “meets” DMSO". Leukemia Research 29 4 (2005): 361-362. http://hdl.handle.net/10451/44650.
    10.1016/j.leukres.2004.09.009
  169. Saldanha, C.; Santos, N.C.; Martins-Silva, J.; Saldanha, Carlota; Santos, Nuno C.; Martins e Silva, João. "A colorimetric process to visualize erythrocyte exovesicles aggregates". Biochemistry and Molecular Biology Education 32 4 (2004): 250-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242803480&partnerID=MN8TOARS.
    10.1002/bmb.2004.494032040374
  170. Santos, N.C.; Castanho, M.A.R.B.. "An overview of the biophysical applications of atomic force microscopy". Biophysical Chemistry 107 2 (2004): 133-149. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242271244&partnerID=MN8TOARS.
    10.1016/j.bpc.2003.09.001
  171. Veiga, S.; Henriques, S.; Santos, N.C.; Castanho, M.. "Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level". Biochemical Journal 377 1 (2004): 107-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642494594&partnerID=MN8TOARS.
    10.1042/BJ20031350
  172. Veiga, A.S.; Santos, N.C.; Loura, L.M.S.; Fedorov, A.; Castanho, M.A.R.B.. "HIV fusion inhibitor peptide T-1249 is able to insert or adsorb to lipidic bilayers. Putative correlation with improved efficiency". Journal of the American Chemical Society 126 45 (2004): 14758-14763. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844228894&partnerID=MN8TOARS.
    10.1021/ja0459882
  173. Santos, N.C.; Figueira-Coelho, J.; Martins-Silva, J.; Saldanha, C.. "Multidisciplinary utilization of dimethyl sulfoxide: Pharmacological, cellular, and molecular aspects". Biochemical Pharmacology 65 7 (2003): 1035-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037379110&partnerID=MN8TOARS.
    10.1016/S0006-2952(03)00002-9
  174. Santos, N.C.; Silva, A.C.; Castanho, M.A.R.B.; Martins-Silva, J.; Saldanha, C.. "Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy". ChemBioChem 4 1 (2003): 96-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037415015&partnerID=MN8TOARS.
    10.1002/cbic.200390020
  175. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Quantifying molecular partition into model systems of biomembranes: An emphasis on optical spectroscopic methods". Biochimica et Biophysica Acta - Biomembranes 1612 2 (2003): 123-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038392423&partnerID=MN8TOARS.
    10.1016/S0005-2736(03)00112-3
  176. Saldanha, C.; Santos, N.C.; Martins-Silva, J.. "Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation". Journal of Membrane Biology 190 1 (2002): 75-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042266862&partnerID=MN8TOARS.
    10.1007/s00232-002-1025-5
  177. Santos, N.C.; Figueira-Coelho, J.; Saldanha, C.; Martins-Silva, J.. "Biochemical, biophysical and haemorheological effects of dimethylsulphoxide on human erythrocyte calcium loading". Cell Calcium 31 4 (2002): 183-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035992044&partnerID=MN8TOARS.
    10.1054/ceca.2002.0271
  178. Santos, N.C.; Fernandes, M.X.J.J.; Castanho, M.A.R.B.. "Overcoming angular dependency when teaching light scattering using a spectrofluorometer: The molecular weights of latex beads". Journal of Chemical Education 76 9 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0040886162&partnerID=MN8TOARS.
  179. Fernandes, M.X.J.J.; Santos, N.C.; Castanho, M.A.R.B.. "Continuous particle size distribution analysis with dynamic light scatteringMAXAMPER: A regularization method using the maximum amplitude for the average error and the Lagrange's multipliers method". Journal of Biochemical and Biophysical Methods 36 2-3 (1998): 101-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031776218&partnerID=MN8TOARS.
    10.1016/S0165-022X(98)00002-5
  180. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Castanho, M.A.R.B.. "Reconstitution of phospholipid bilayer by an atomic force microscope tip [2]". Biophysical Journal 75 4 (1998): 2119-2120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031682589&partnerID=MN8TOARS.
  181. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Prieto, M.; Castanho, M.A.R.B.. "Filipin-induced lesions in planar phospholipid bilayers imaged by atomic force microscopy". Biophysical Journal 75 4 (1998): 1869-1873. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031690831&partnerID=MN8TOARS.
  182. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study". Biochemistry 37 24 (1998): 8674-8682. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032537597&partnerID=MN8TOARS.
    10.1021/bi9803933
  183. Santos, N.C.; Castanho, M.A.R.B.. "Erratum: (Biophysical Journal (1996) 71 (1641-1650))". Biophysical Journal 72 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031055305&partnerID=MN8TOARS.
  184. Castanho, MARB; Santos, NC; Loura, LMS. "Separating the turbidity spectra of vesicles from the absorption spectra of membrane probes and other chromophores". European Biophysics Journal With Biophysics Letters 26 3 (1997): 253-259.
    10.1007/s002490050078
  185. Santos, N.C.; Sousa, A.M.A.; Betbeder, D.; Prieto, M.; Castanho, M.A.R.B.. "Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy". Carbohydrate Research 300 1 (1997): 31-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030988131&partnerID=MN8TOARS.
    10.1016/S0008-6215(97)00025-6
  186. Santos, N.C.; Prieto, M.J.E.; Morna-Gomes, A.; Betbeder, D.; Castanho, M.A.R.B.. "Structural characterization (shape and dimensions) and stability of polysaccharide/lipid nanoparticles". Biopolymers 41 5 (1997): 511-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031127551&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0282(19970415)41:5<511::AID-BIP3>3.0.CO;2-P
  187. Santos, N.C.; Castanho, M.A.R.B.. "Teaching light scattering spectroscopy: The dimension and shape of tobacco mosaic virus". Biophysical Journal 71 3 (1996): 1641-1650. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029738097&partnerID=MN8TOARS.
Manual
  1. Quialheiro, A.; Miranda, André; Garcia Júnior, M.; Santos, N.C.; Camargo, A.; Correia-Neves, M.. Manual do projeto OITO: oficinas de inclusão tecnológica online. Portugal. 2021.
    Published • 10.21814/1822.74175
Preprint
  1. Sabino, João C.; de Almeida, Madalena R.; Abreu, Patricia L.; Ferreira, Ana M.; Domingues, Marco M.; Santos, Nuno C.; Azzalin, Claus; Grosso, Ana R.; de Almeida, Sérgio F.. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". 2021. http://dx.doi.org/10.1101/2021.04.26.441414.
    10.1101/2021.04.26.441414
Thesis / Dissertation
  1. MATINHOS, Renata Pereira das Neves Baptista. "A new antiviral strategy for pandemic and seasonal influenza". Master, 2024. http://hdl.handle.net/10362/178366.
  2. Guedes, Ana Filipa. "Molecular characterization of the fibrinogen-erythrocyte interaction as a cardiovascular risk". PhD, 2018. http://hdl.handle.net/10451/36920.
  3. Silva, Patrícia Morgado da. "Broad-spectrum antiviral peptides against respiratory viruses". Master, 2016. http://hdl.handle.net/10451/24665.
  4. Rodrigues, Margarida Filipe Dias. "Molecular determinants of the cellular internalization of crotamine-derived peptides". PhD, 2014. http://hdl.handle.net/10451/11459.
  5. Matos, Pedro, 1985-. "Shedding light on enveloped viruses entry and its inhibition using optical techniques". PhD, 2013. http://hdl.handle.net/10451/11260.
  6. Carvalho, Filomena A., 1976-. "Studying single-molecule protein interactions and its biological and biomedical applications by AFM-based force spectroscopy". PhD, 2012. http://hdl.handle.net/10451/7426.
  7. Domingues, Marco André Manso, 1985-. "Study of the mechanism of action of the antimicrobial peptide rBPI21 in gram-negative bacteria". PhD, 2012. http://hdl.handle.net/10451/8633.
  8. Franquelim, Henri Girão,1984-. "The role of lipid membranes in the mechanism of action of sifuvirtide and other HIV-1 fusion inhibitors". PhD, 2012. http://hdl.handle.net/10451/7113.
  9. Faustino, André Filipe da Costa. "Molecular level evaluation of the dengue virus capsid protein role(s) on the virus life cycle". Master, 2011. http://hdl.handle.net/10451/8945.

Other

Other output
  1. Complexation and full characterization of the tretinoin and dimethyl-ßeta-cyclodextrin complex. Abstract. The aim of this work is to prepare tretinoin/dimethyl-beta-cyclodextrin complexes and fully characterize them through various analytical techniques. According to the phase solubility studies performed, the equilibrium for maximum complexation is reached in about 8 days presenting an AL-type diagram (soluble complexes) corresponding mainly to 1:1 stoichiometry (Ks=13,600 M-1), although th. 2011. Ascenso, Andreia; Guedes, Rita; Bernardino, Raul; Diogo, Herminio; Carvalho, Filomena A.; Santos, Nuno C.; Silva, Aida M.; Marques, Helena Cabral. http://dx.doi.org/10.1208/s12249-011-9612-.
    http://dx.doi.org/10.1208/s12249-011-9612-
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - 2023/03/10 Flavivirus capsid proteins interaction with host lipid systems and viral RNA
Co-supervisor
 Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2020/10/08 Design and mechanistic characterization of novel antimicrobial and anticancer peptides
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020/04/17 Desenho racional de peptídeos análogos ao neuropeptídeo Y para o tratamento da obesidade
Co-supervisor of Beatriz Torres Meneguetti Mandruzzato
 Biotecnologia (PhD)
Universidade Católica Dom Bosco, Brazil
2014 - 2018/12/18 Enveloped viruses - a peptide inhibition strategy
Supervisor of Marcelo Alexandre da Costa Tavares Augusto
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2018/10/12 Characterization of enveloped viruses inhibition by 25-hydroxycholesterol at the membrane level
Supervisor of Bárbara Sofia Lopes Gomes
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2018/07/11 Molecular characterization of the fibrinogen-erythrocyte interaction as a cardiovascular risk
Supervisor of Ana Filipa Barata Duarte Guedes
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2016/07/04 Dengue virus capsid protein structural and functional studies: a gateway for possible dengue inhibition strategies
Supervisor of André Filipe da Costa Faustino
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2014/03/03 Molecular determinants of the celular internalization of crotamine-derived peptides
Supervisor of Margarida Filipe Dias Rodrigues
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2013/07/10 Shedding light on enveloped viruses entry and its inhibition using optical techniques
Supervisor of Pedro Miguel Baptista de Matos
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/12/19 Study of the mechanism of action of the antimicrobial peptide rBPI21 in Gram-negative bacteria
Supervisor of Marco André Manso Domingues
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/12 The role of lipid membranes in the mechanism of action of sifuvirtide and other HIV-1 fusion inhibitors
Co-supervisor of Henri Girão Franquelim
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/03 Studying single-molecule protein interactions and its biological and biomedical applications by AFM-based force spectroscopy
Supervisor of Filomena Maria Dias Almeida Carvalho Arede
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2019/09/04 - Current Ambassador of the Biophysical Society (USA) Ambassador
2019/07/23 - Current Member of the Executive Committee of the European Biophysical Societies' Association (EBSA) Member
2018/03/27 - Current National Representative of Portugal at the European Peptide Society National Representative
2017/04/01 - Current Presidente da Mesa da Assembleia do Colégio de Química da Universidade de Lisboa Presidente da Mesa da Assembleia
2015/05/13 - 2021/11/05 President of the Portuguese Biophysical Society President
2008/10/01 - 2015/05/13 Treasurer of the Portuguese Biophysical Society Treasurer
Distinctions

Award

2023 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2017 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
2005 Dr. José Luís Champalimaud Prize (Applied Research and Technologies area)
2004 Dr. José Luís Champalimaud Prize (Basic Research area)
2001 Programa Gulbenkian de Estímulo à Investigação
Fundação Calouste Gulbenkian, Portugal