???global.info.a_carregar???
For the past 14 years, Guadalupe Cabral has been acting as Invited Assistant professor, at NMS, UNL and recently she secured a position as Principal Investigator from LS4FUTURE/iNOVA4Health, at the same institution, thus establishing her independent research group. The new TRANSLATIONAL TUMOR IMMUNOLOGY group, is focused on understanding the immunobiology of human solid cancers and developing innovative tools to improve the management of these diseases. She obtained her Biology degree in 1999 from Faculdade de Ciências (Universidade de Lisboa) and in 2000 she was honored with a PhD fellowship from Fundação para a Ciência e Tecnologia. During her fellowship, conducted at Instituto Superior Técnico, she specialized in the field of Yeast Physiology and in 2006, she embarked on a brief postdoc in Plant Biotechnology, at ITQB. However, it was only in 2007, when Guadalupe embraced a new postdoc at the Glycoimmunology group at NMS, UNL, that she found her genuine scientific passion – understanding the Mechanisms of Diseases and exploring strategies to treat them. In 2016, she moved to the Tissue Repair and Inflammation Group, where she was able to launch an investigation line in the field of IMMUNE-ONCOLOGY, specifically focused in the study of the immune characteristics of breast cancer (BC). The success of her recent research is evident by the numerous contributions to the field, including 5 peer-reviewed articles and numerous oral communications and posters at national and international conferences. Moreover, she was honoured with several prestigious distinctions, such as the Medicine Research Prize 2018 (by Tagus Tank Consortium), the Terry Fox Research Grant 2019 (by Liga Portuguesa Contra o Cancro), the Clinical Investigation Prize 2019 (by Pfizer/Sociedade das Ciências Médicas) and more recently the CaixaImpulse Innovation 2023 (by “la Caixa” foundation), the Research grant 2024 from Liga Portuguesa Contra o Cancro and the Research Grant 2024 from the Gilead Genese Program. Overall, her track record demonstrates a strong commitment to scientific research and contributions to the field, reflected by 33 peer-reviewed articles, published primary in journals with respectable impact factors, and 3 book chapters, as well as an active involvement in mentoring and supporting the next generation of researchers (beside teaching classes to all the levels of academic studies, she have successfully supervised 3 PhD and 7 Master students and, currently she supervises supervise 5 PhD and 1 master students). Currently, Guadalupe’s main goal is to understand whether the prevalence of particular immune features in the tumor microenvironment of Breast Cancer and/or in the patients’ blood have the potential to be translated into reliable predictive/prognostic biomarkers and to guide the development of new immune-based therapeutic. Ultimately, she intends to translate the scientific discoveries of her team into tangible improvements in cancer management, thus positively impacting the lives of patients and contributing to a broader fight against cancer.
Read full resume ↓
Identification

Personal identification

Full name
Maria de Guadalupe Gonçalves Cabral

Citation names

  • Cabral, Maria Guadalupe
  • Cabral, MG

Author identifiers

Ciência ID
CB1B-C82A-D84A
ORCID iD
0000-0001-9016-9173

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2024/01/30 - 2024/02/01
Attended
 Leadership Course for Young Principal Investigators (Outros)
LS4FUTURE, Portugal
2021 - 2021
Concluded
 Scicare- Novartis Health Science Accelerator program (Outros)
Novartis Portugal, Portugal
2019 - 2019
Concluded
 Developing Supervisory skills (Outros)
Universidade Nova de Lisboa, Portugal
2017/03 - 2017/03
Concluded
 Theoretical course on Laboratory Animals’ Science and practical course on Animal handling experimentation in Mice and Zebrafish (Outros)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2000/01/01 - 2004/07/22
Concluded
 Biotechnology (Doutoramento)
Major in Biotechnology
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Avaliação da toxicidade e mecanismos de adaptação a herbicidas clorofenoxiacéticos: a levedura Saccharomyces cerevisiae como modelo experimental eucariótico." (THESIS/DISSERTATION)
 NA
1994/09 - 1999/09/07
Concluded
 Biology (Licenciatura)
Major in Microbial Biology and Genetics
Universidade de Lisboa Faculdade de Ciências, Portugal
"Mecanismos de aquisição de tolerância ao ácido fraco conservante alimentar ácido octanóico na levedura Saccharomyces cerevisiae." (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/01/01 - Current Principal Investigator (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/01/01 - Current Invited Auxiliary Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018/02/03 - 2018/04/07 Visiting Researcher (Research) Innovimmune Biotherapeutics, United States
2007/01/01 - 2011/12/31 Postdoc (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2008/06/01 - 2008/07/31 Visiting Researcher (Research) Roswell Park Cancer Institute, United States
2006/01/01 - 2006/12/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006/06/15 - 2006/07/15 Visiting Researcher (Research) Centro de Investigaciones Biológicas, Spain
2000/01/01 - 2003/12/31 Researcher (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
1998/09/10 - 1999/12/31 Research Trainee (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012/09/01 - Current Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012/03/01 - 2018/08/31 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011/12/30 - 2012/05/31 Assistant (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007/09/01 - 2011/03/01 Lecturer (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010/06/01 - 2010/08/01 Visiting Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2003/10/01 - 2005/12/31 Lecturer (University Teacher) Escola Superior de Biologia e Saúde, Portugal

Other Careers

Category
Host institution 		Employer
2004/11/01 - 2005/12/31 Técnico Superior (Técnico Superior) UNAC - União da Floresta Mediterrânica , Portugal
Projects

Grant

Designation Funders
2025/02/04 - Current Personalizing immunotherapy for high-risk early-stage triple negative Breast cancer by targeting immunosuppressive neutrophils.
Bolsa de Investigação da Liga Portuguesa Contra o Cancro
Principal investigator
Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Liga Portuguesa Contra o Cancro
Ongoing
2023/01/01 - 2025/06/30 OntoGlia: How the brain’s immune cells develop: the role of Deleted in Autism-1 Related (DIA1R) in microglia ontogeny
2022.02611.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
2021/01/01 - 2023/12/31 Cracking the role and therapeutic value of a novel subset of low density neutrophils in breast cancer
UIDB/04462/2020
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 iNOVA4Health
Ongoing
2019 - 2021 HLA-DR+T cell subsets as biomarkers of breast cancer aggressiveness and patients’ response to neoadjuvant chemotherapy.
Research Projects in Medicine Prize 2018
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Tagus Tank Consortium
Ongoing
2016 - 2018 Searching positive biomarkers in Triple negative breast cancer (TNBC)
UID/Multi/04462/2013-Lisboa-01-0145FEDER-007
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2025/02/11 - Current Targeting Immunosuppressive Neutrophils: Unlocking new pathways in Immune Oncology to improve Triple Negative Breast Cancer treatments.
Research Grant Gilead Génese
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Gilead Sciences Lda
Ongoing
2023/10/01 - Current Neutrotarget - New subset of neutrophils as a biomarker and therapeutic target for metastatic Breast Cancer
CI23-10380
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Caixa d'Estalvis i Pensions de Barcelona
Ongoing
2023/09/01 - Current Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

GREEN-IT, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2025/01/01 - 2027/09/30 MPS NOVA Hub: Advanced Microphysiological Systems and Pluripotent Stem Cell Technologies to Unveil Chronic Disease Mechanisms and Host-Microbe
101159729
Researcher
Universidade Nova de Lisboa, Portugal
 Horizon 2020
Ongoing
2019/03/01 - 2022/09/30 TARGUT- Targetting early stages of gut inflammation Fundação para a Ciência e Tecnologia
PTDC/BTM-SAL/29377/2017
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Ongoing
2019 - 2021 Dissecting the predictive and therapeutic value of HLA-DR expressing T Lymphocytes in Breast Cancer
Terry Fox Research Grant 2019
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Liga Portuguesa Contra o Cancro
Ongoing
2016 - 2020 Therapeutic Targets for Triple Negative Breast Cancer: Development of mono and bispecific antibodies against Notch1 ligands.
PTDC/BBB-BMD/4497/2014
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2007 - 2010 The role of Sialic acid in the Immunobiology of the Dendritic Cell
PTDC/SAU-MII/67561/2006
Post-doc
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2007 Transgenic Plants as models to study transgenes expression regulation and deposition of recombinants protein
POCI/BIA-BCM/55762/2004
Post-doc
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2004 Resistance to benomyl and other fungicides in Saccharomyces cerevisiae: role of multidrug transporters and their regulation.
POCTI/AGG/38110/2001
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2004 HERBICBIOREM Strategies to accelerate the productive biodegradation of several herbicides under environmental stress conditions.
QLK3-CT-1999-00041
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 European Commission
Concluded
2000 - 2001 European network for the functional analysis of yeast genes discovered by systematic sequencing (phase II) / EUROFAN II / Transport node.
BIO4-CT97-2294
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 European Commission
Concluded
1998 - 1999 Effects of weak acid food preservatives in the yeast Sacharomyces cerevisiae: acquisition of tolerance and underlying mechanisms.
JNICT-pbic/c/bio/2031/95
Scientific Initiation Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020/04/15 - 2020/05/31 Serology4COVID19
Serology4COVID19
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Sofia Jacinto; Dias, Sonia; Ana Gama; Cabral, Maria Guadalupe; António Jacinto. "Fighting cancer in all fronts". In From life molecules to global health, 265-371. Princípia, 2021.
    Published
  2. Carrascal, Mylène A.; Silva, Zélia; Crespo, Hélio J.; Cabral, M. Guadalupe; Videira, Paula A.. "Chapter 4. Sialylation and dendritic cells: bridging innate and adaptive immune responses". In Carbohydrate Chemistry, 94-116. Cambridge: Royal Society of Chemistry, 2011.
    Published • 10.1039/9781849732765-00094
  3. Cabral, Maria Guadalupe; Crespo, Hélio J.; Ligeiro, Dário; Piteira, Ana Rita; Videira, Paula A.. "Capter 7: Sialic acids as modulators of endocytosis: the case of dendritic cells.". New York, United States: Nova Science Publishers, Inc., NY, 2010.
    Published
Conference abstract
  1. Cabral, MG. Corresponding author: Cabral, MG. "Low-density neutrophils in breast cancer: prognostic significance and therapeutic potential". Paper presented in 50 Meeting from Sociedade Portuguesa de Imunologia (SPI), Lisbon, 2025.
    Accepted
  2. Cabral, MG. Corresponding author: Cabral, MG. "Immunosuppressive low-density neutrophils as mediators of breast cancer progression and immune evasion". Paper presented in 50 Meeting from Sociedade Portuguesa de Imunologia (SPI), Lisbon, 2025.
    Accepted
  3. Cabral, MG. Corresponding author: Cabral, MG. "HLA-DR-expressing Cytotoxic T Lymphocytes drive the effectiveness of T cell-based therapies in Breast Cancer". Paper presented in EACR 2025 - Annual Congress of the European Association for Cancer ResearchCR 2025, Lisbon, 2025.
    Accepted
  4. Cabral, MG. Corresponding author: Cabral, MG. "Low Density Neutrophils as Key Mediators of Breast Cancer Progression: Strengthening Evidence for Arginase-Driven Immune Evasion in Future Treatments". 2025.
    Accepted
  5. Cabral, MG. Corresponding author: Cabral, MG. "Low Density Neutrophils: A Valuable Clinical Tool for Monitoring Metastatic Breast Cancer Progression and Treatment Decisions". Paper presented in EACR 2025 - Annual Congress of the European Association for Cancer ResearchCR 2025, Lisbon, 2025.
    Accepted
Conference poster
  1. Martins, Telma; Correia, Bruna Filipa; Grosa, Daniela; Salvador, Rute; Brites, Inês; Xavier de Sousa, Carolina; Idília Pina; et al. "The Prognostic Value of Low Density Neutrophils in Breast Cancer: Implications for Therapeutic Strategies". Paper presented in ESMO Immuno-Oncology Congress 2024, 2024.
  2. Bruna Correia; Diana P. Saraiva; Rute Salvador; António Jacinto; Cabral, Maria Guadalupe. "Unveiling the clinical relevance of low density neutrophils in Breast Cancer patients.". Paper presented in AIMS Meeting - Reunião Anual Internacional de Estudantes de Medicina,, 2021.
  3. Bruna Correia; Diana P. Saraiva; Sofia Braga; Cabral, Maria Guadalupe. "Low density neutrophils are associated with a worse prognosis in Breast Cancer.". Paper presented in iMed Conference 12.0, 2020.
  4. Diana P. Saraiva; António Jacinto; Ana Antunes; Sofia Azeredo-Lopes; Sofia Braga; Cabral, Maria Guadalupe. "HLA-DRhigh cytotoxic T cells as a validated and independent predictive biomarker and as a potential therapeutic approach.". Paper presented in Cancer Biology: from basic to translational research (Liga Portuguesa Contra o Cancro), 2020.
  5. Coelho, Silvia; Salvador, Rute; Cabral, Maria Guadalupe; Jacinto, António. "B Cells are associated with renal recovery after Acute Kidney Injury.". Paper presented in American Society of Nephrology (ASN), 2019.
  6. Saraiva, Diana P; Braga,; Jacinto, António; Cabral, Maria Guadalupe. "Validation of the predictive value of HLA- DR+ Cytotoxic T Lymphocytes in the response of Breast Cancer patients’ to Neoadjuvant Chemotherapy.". Paper presented in 2nd Human and Translational Immunology Conference, 2019.
  7. Jacinta Fernandes, Ana ; Matias, Ana Teresa; Magno, Ramiro; Xavier, Joana M; Cabral, Maria Guadalupe; Jacinto, António; Maia, Ana Teresa; et al. "Differential molecular signature inpatients from African origin with Triple-Negative Breast Cancer". Paper presented in ESMO2018, 2018.
    10.1093/annonc/mdy272.290
  8. Saraiva, Diana P; Braga, Sofia; Jacinto, António; Cabral, Maria Guadalupe; Saraiva, D P; Jacinto, A; Braga, S; Cabral, M G. "A new biomarker of breast cancer stage and patient response to neoadjuvant chemotherapy: HLA-DR expression in cytotoxic and regulatory T cells.". Paper presented in ESMO 2018, 2018.
    10.1093/annonc/mdy269.118
  9. Saraiva, Diana P; Braga, Sofia; Jacinto, António; Cabral, Maria Guadalupe. "HLA-DR in cytotoxic and regulatory T cells dictates breast cancer aggressiveness and patient response to neoadjuvant chemotherapy.". Paper presented in 5th European Congress of Immunology, 2018.
  10. Saraiva, Diana P.; Braga, Sofia; Jacinto, António; Cabral, Maria Guadalupe. "HLA-DR expression in cytotoxic T Lymphocytes: A new predictor of Breast Cancer patients’ response to neoadjuvant chemotherapy.". Paper presented in XLIV Meeting of Portuguese Society of Immunology, 2018.
  11. Saraiva, Diana P.; Braga, Sofia; Jacinto, António; Cabral, Maria Guadalupe. "Establishment of a prospective study to unveil the predictive value of breast cancer immune features in the response to neoadjuvant chemotherapy.". Paper presented in 4th Conference on Translational Medicine on Pathogenesis and Therapy of Immune-mediated diseases, 2017.
  12. Cabral, Maria Guadalupe; Silva, JF; Silva, AC; Santos, S; Mendo, A.S.; Coito, L.; Videira, Paula A; et al. "Antiproliferative activity and biological targets of Pt(II) and Cu(II) compounds.". Paper presented in 20th EuCheMS Conference on Organometallic Chemistry, 2013.
    10.3390/mol2net-03-04629
  13. Cabral, Maria Guadalupe; Lopes, Andreia; Coutinho, Carla; Sá-Correia, Isabel; Videira, Paula A; Pereira, Marília; Videira, Paula A.. "Modulation of dendritic cell functions by Burkholderia cenocepacia bacteria isolated from a cystic fibrosis patient.". Paper presented in XXXVIII meeting da Sociedade Portuguesa de Imunologia, 2012.
  14. CRESPO, HÉLIO; Carrascal, Mylène; Silva, Mariana; Cabral, Maria Guadalupe; Silva, Zélia; Ligeiro, Dário; Lau, Joseph T. Y.; Videira, Paula Alexandra Quintela. "Human dendritic cell functions: modulation by self-sialylated glycans". Paper presented in XXXVIII Annual Meeting of the Portuguese Society of Immunology, 2012.
  15. Carrascal, Mylène A; Severino, Paulo F; Cabral, Maria Guadalupe; Gouveia, Helena; Silva, Mariana; Dall’Olio, Fabio; Videira, Paula A; et al. "Immune Tolerance to Cancer Cells: the Role of Sialyl Tn Antigen.". Paper presented in Glycoscience-Aplications to human and health and diseases, 2011.
    10.3320/1.2758723
  16. Cabral, Maria Guadalupe; Silva, Zelia; Ligeiro, Dário; Seixas, Elsa; Videira, Paula A.. "Desialylation improves phagocytosis by human dendritic cells.". Paper presented in Consortium for Functional Glycomics Participating Investigator Meeting at the National Institutes of Health (NIH), 2011.
Journal article
  1. Salvador, Rute; Correia, Bruna Filipa; Grosa, Daniela; Martins, Telma; Baal, Suelen ; Cristovão-Feirreira, Sofia; Pereira, Isabel Lopes; et al. Corresponding author: Cabral, MG. "HLA-DR expression in Cytotoxic T Lymphocytes is crucial for increasing the therapeutic potential of T cell-based strategies for Breast Cancer (under revision).". Scientific Report (2025):
    Under revision
  2. Cabral, MG. Corresponding author: Cabral, MG. "Neutrophils matter: New clinical insights on their role in the progression of metastatic breast cancer (submitted)". Breast Cancer Research (2025):
    Open access • Submitted
  3. Correia, B.F.C.; Grosa, D.S.C.P.; Salvador, R.M.S.; Brites, I.; Martins, T.S.; de Sousa, C.X.; Pina, I.M.R. Matos; et al. Corresponding author: Cabral, G.. "201P Underlying mechanisms of neutrophil-mediated immunosuppression and resistance to treatment in breast cancer: Further evidence that these cells matter (Abstract)". Immuno-Oncology and Technology 24 (2024): 100954. https://doi.org/10.1016/j.iotech.2024.100954.
    10.1016/j.iotech.2024.100954
  4. Martins, T.S.; Correia, B.F.C.; Grosa, D.S.C.P.; Salvador, R.M.S.; Brites, I.; de Sousa, C.X.; Pina, I.M.R. Matos; et al. "30P The prognostic value of low density neutrophils in breast cancer: Implications for therapeutic strategies (Abstract)". Immuno-Oncology and Technology 24 (2024): 100912. https://doi.org/10.1016/j.iotech.2024.100912.
    10.1016/j.iotech.2024.100912
  5. Domingues, Neuza; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P.; Bento, Luís; Marques, André R.A.; Soares, Maria I.L.; et al. "Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation". Journal of Lipid Research 64 9 (2023): 100419. http://dx.doi.org/10.1016/j.jlr.2023.100419.
    10.1016/j.jlr.2023.100419
  6. Ferreira, Ana Carina; Mendes, Marco; Silva, Cecília; Cotovio, Patrícia; Aires, Inês; Navarro, David; Caeiro, Fernando; et al. "Improvement of Mineral and Bone Disorders After Renal Transplantation". Transplantation 106 5 (2022): e251-e261. http://dx.doi.org/10.1097/tp.0000000000004099.
    10.1097/tp.0000000000004099
  7. Coelho, Sílvia; Cabral, Maria Guadalupe; Salvador, Rute; Andrade, Cláudia; Martins, Ana; Correia, Bruna; Freitas, Paulo; Cruzado, Josep Maria; Jacinto, António. "Urinary immune cell phenotype of severe AKI in critically ill patients". International Urology and Nephrology (2022): http://dx.doi.org/10.1007/s11255-021-03088-y.
    Open access • Published • 10.1007/s11255-021-03088-y
  8. Saraiva, Diana P.; Correia, Bruna F.; Salvador, Rute; de Sousa, Nídia; Jacinto, António; Braga, Sofia; Cabral, M. Guadalupe. Corresponding author: Cabral, M. Guadalupe. "Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses". Oncotarget 12 24 (2021): 2388-2403. http://dx.doi.org/10.18632/oncotarget.28135.
    Open access • Published • 10.18632/oncotarget.28135
  9. Ferreira, Ana Carina; Cotovio, Patrícia; Aires, Inês; Mendes, Marco; Navarro, David; Silva, Cecília; Caeiro, Fernando; et al. "The Role of Bone Volume, FGF23 and Sclerostin in Calcifications and Mortality; a Cohort Study in CKD Stage 5 Patients". Calcified Tissue International 110 2 (2021): 215-224. http://dx.doi.org/10.1007/s00223-021-00910-8.
    Open access • Published • 10.1007/s00223-021-00910-8
  10. Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; et al. "Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer". Cancers 13 16 (2021): 4074. http://dx.doi.org/10.3390/cancers13164074.
    Open access • Published • 10.3390/cancers13164074
  11. Saraiva, Diana P.; Azeredo-Lopes, Sofia; Antunes, Ana; Salvador, Rute; Borralho, Paula; Assis, Beatriz; Pereira, Isabel L.; et al. Corresponding author: Cabral, M. Guadalupe. "Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomarker and a Potential Therapeutic Strategy in Breast Cancer". Cancers 13 15 (2021): 3841. http://dx.doi.org/10.3390/cancers13153841.
    Open access • Published • 10.3390/cancers13153841
  12. Ferreira, Ana Carina; Mendes, Marco; Silva, Cecília; Cotovio, Patrícia; Aires, Inês; Navarro, David; Caeiro, Fernando; et al. "Bone densitometry versus bone histomorphometry in renal transplanted patients: a cross-sectional study". Transplant International 34 6 (2021): 1065-1073. http://dx.doi.org/10.1111/tri.13888.
    Open access • Published • 10.1111/tri.13888
  13. Gonçalves, Juliana; Sousa, Rita L.; Jacinto, Maria J.; Silva, Daniela A.; Paula, Filipe; Sousa, Rute; Zahedi, Sara; et al. "Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measures". Frontiers in Medicine 7 (2020): http://dx.doi.org/10.3389/fmed.2020.603996.
    Published • 10.3389/fmed.2020.603996
  14. Ana T Matias; Ana Jacinta-Fernandes; Sofia Braga; António Jacinto; Cabral, Maria Guadalupe. "Differential expression between African-ancestry and White patients diagnosed with Triple-Negative Breast Cancer: EGFR, Myc, Bcl2 and ß-Catenin as ancestry-associated markers". BioRxive (2020): https://www.biorxiv.org/content/10.1101/2020.11.13.381608v1.
    Published
  15. Saraiva, Diana P.; Matias, Ana T.; Braga, Sofia; Jacinto, António; Cabral, M. Guadalupe. Corresponding author: Cabral, M. Guadalupe. "Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of Immunotherapies". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.01543.
    Open access • Published • 10.3389/fonc.2020.01543
  16. Saraiva, D.P.; Jacinto, A.; Braga, S.; Cabral, M.G.. Corresponding author: Cabral, M.G.. "A 3D co-culture platform of breast cancer and patient derived immune cells to analyse the response to chemotherapy and immunotherapies (Abstract)". Annals of Oncology 30 (2019): v781. http://dx.doi.org/10.1093/annonc/mdz268.064.
    Published • 10.1093/annonc/mdz268.064
  17. Casal, Diogo; Iria, Inês; Ramalho, José S.; Alves, Sara; Mota-Silva, Eduarda; Mascarenhas-Lemos, Luís; Pontinha, Carlos; et al. "BD-2 and BD-3 increase skin flap survival in a model of ischemia and Pseudomonas aeruginosa infection". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-44153-y.
    Open access • 10.1038/s41598-019-44153-y
  18. Saraiva, Diana P.; Jacinto, António; Borralho, Paula; Braga, Sofia; Cabral, M. Guadalupe. Corresponding author: Cabral, M. Guadalupe. "HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy". Frontiers in Immunology 13 9:2605 (2018): http://dx.doi.org/10.3389/fimmu.2018.02605.
    Open access • Published • 10.3389/fimmu.2018.02605
  19. Coelho, Silvia; Cabral, M. Guadalupe; Lopes, José A; Jacinto, António. "Renal regeneration after acute kidney injury". Nephrology 23 9 (2018): 805-814. http://dx.doi.org/10.1111/nep.13256.
    Open access • Published • 10.1111/nep.13256
  20. do Nascimento-Neto, Luiz G.; Cabral, M. Guadalupe; Carneiro, Romulo F.; Silva, Zelia; Arruda, Francisco V.S.; Nagano, Celso S.; Fernandes, Alexandra R.; et al. "Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression". Anti-Cancer Agents in Medicinal Chemistry 18 4 (2018): 521-528. http://dx.doi.org/10.2174/1871520617666171114094847.
    Published • 10.2174/1871520617666171114094847
  21. Chaves, Renata Pinheiro; Silva, Suzete Roberta da; Nascimento Neto, Luiz Gonzaga; Carneiro, Romulo Farias; Silva, André Luis Coelho da; Sampaio, Alexandre Holanda; Sousa, Bruno Lopes de; et al. "Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells". International Journal of Biological Macromolecules 107 (2018): 1320-1329. http://dx.doi.org/10.1016/j.ijbiomac.2017.09.116.
    Published • 10.1016/j.ijbiomac.2017.09.116
  22. Saraiva, Diana P; Cabral, M. Guadalupe; Jacinto, António; Braga, Sofia. "How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment". ESMO Open 2 4 (2017): e000208. http://dx.doi.org/10.1136/esmoopen-2017-000208.
    Open access • Published • 10.1136/esmoopen-2017-000208
  23. Calais da Silva, Fernando M.; Videira, Paula A.; Ligeiro, Dário; Cabral, Maria Guadalupe; Sylvester, Richard; Calais da Silva, Fernando E.; Trindade, Hélder. "Systemic humoral responses of non-muscle-invasive bladder cancer during BCG treatment: less is more". Journal of Cancer Metastasis and Treatment 3 7 (2017): 116-126. http://dx.doi.org/10.20517/2394-4722.2017.25.
    Open access • Published • 10.20517/2394-4722.2017.25
  24. Cabral, M. Guadalupe; Pereira, Marília; Silva, Zélia; Iria, Inês; Coutinho, Carla; Lopes, Andreia; Sá-Correia, Isabel; Videira, Paula A.. "Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions". Medical Microbiology and Immunology 206 2 (2016): 111-123. http://dx.doi.org/10.1007/s00430-016-0488-4.
    Open access • Published • 10.1007/s00430-016-0488-4
  25. Carrascal MA; Severino PF; Guadalupe Cabral M; Silva M; Ferreira JA; Calais F; Quinto H; et al. "Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.". Molecular Oncolology 8 3 (2014): 753-756. http://europepmc.org/abstract/med/24656965.
    Open access • Published • 10.1016/j.molonc.2014.02.008
  26. Pereira, M.J.; Coutinho, C.P.; Lopes, A.; Sá-Correia, I.; Videira, P.A.; Cabral, M.G.. "172 Modulation of dendritic cell functions by clonal variants of Burkholderia cenocepacia isolated from a cystic fibrosis patient (Abstract)". Journal of Cystic Fibrosis 12 suppl1 (2013): S92. http://dx.doi.org/10.1016/s1569-1993(13)60313-6.
    Published • 10.1016/s1569-1993(13)60313-6
  27. Monteiro, A.S.; Almeida, J.; Cabral, M. G.; Severino, P.; Videira, P.A.; Sousa, A.; Nunes, R.; et al. "Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines". European Journal of Medicinal Chemistry 70 (2013): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885368654&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2013.09.040
  28. Silva, A.; Luís, D.; Santos, S.; Silva, J.; Mendo, A.S.; Coito, L.; Silva, T.F.S.; et al. "Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: A comparative proteomic approach". Drug Metabolism and Drug Interactions 28 3 (2013): 167-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888103842&partnerID=MN8TOARS.
    Published • 10.1515/dmdi-2013-0015
  29. Cabral, M.G.; Silva, Z.; Ligeiro, D.; Seixas, E.; Crespo, H.; Carrascal, M.A.; Silva, M.; et al. "The phagocytic capacity and immunological potency of human dendritic cells is improved by a2,6-sialic acid deficiency". Immunology 138 3 (2013): 235-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873294436&partnerID=MN8TOARS.
    Published • 10.1111/imm.12025
  30. Silva, Z.; Tong, Z.; Guadalupe Cabral, M.; Martins, C.; Castro, R.; Reis, C.; Trindade, H.; Konstantopoulos, K.; Videira, P.A.. "Sialyl Lewisx-dependent binding of human monocyte-derived dendritic cells to selectins". Biochemical and Biophysical Research Communications 409 3 (2011): 459-464. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051577888&partnerID=MN8TOARS.
    Published • 10.1016/j.bbrc.2011.05.026
  31. Videira, P.A.; Piteira, A.R.; Cabral, M.G.; Martins, C.; Correia, M.; Severino, P.; Gouveia, H.; et al. "Effects of bevacizumab on autocrine VEGF stimulation in bladder cancer cell lines". Urologia Internationalis 86 1 (2011): 95-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951812607&partnerID=MN8TOARS.
    Published • 10.1159/000321905
  32. Severino, Paulo F; Carrascal, Mylène A; Gouveia, Helena; Cabral, M Guadalupe; Correia, Manuela; Malagolini, Nadia; Chiricolo, Mariella; et al. "Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line models (Abstract)". BMC Proceedings 4 S2 (2010): http://dx.doi.org/10.1186/1753-6561-4-s2-p48.
    Published
  33. Cabral, M.G.; Piteira, A.R.; Silva, Z.; Ligeiro, D.; Brossmer, R.; Videira, P.A.. "Human dendritic cells contain cell surface sialyltransferase activity". Immunology Letters 131 1 (2010): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954759617&partnerID=MN8TOARS.
    Published • 10.1016/j.imlet.2010.02.009
  34. Silva, Zélia; Tong, Ziqiu; Cabral, Maria Guadalupe; Martins, Catarina; Faria, Rita; Konstantopoulos, Konstantinos; Videira, Paula A.. "Slex is involved in the interaction of Human Dendritic Cells with Selectins (Abstract)". Glycobiology 20 (2010): 1520.
    Published
  35. Cabral, Maria Guadalupe; Crespo, Hélio J.; Silva, Zélia; Lau, Joseph T. Y.; Trindade, Hélder; Videira, Paula A.. "N-Acetylneuraminic Acid (Neu5Ac) Functional Impact on Human and Mice Dendritic Cells (Abstract)". Glycobiology 20 (2010): 1519.
    Published
  36. Cabral, Maria Guadalupe; Ligeiro, Dário; Silva, Zélia; Piteira, Ana Rita; Videira, Paula A.. "Sialic acid removal improves phagocytosis capacity of human dendritic cells". European Journal of Clinical Investigation 40 suppl1 (2010): 30.
    Published
  37. Crespo, H.J.; Guadalupe Cabral, M.; Teixeira, A.V.; Lau, J.T.Y.; Trindade, H.; Videira, P.A.. "Effect of sialic acid loss on dendritic cell maturation". Immunology 128 1suppl (2009): 621-631. http://www.scopus.com/inward/record.url?eid=2-s2.0-68249162075&partnerID=MN8TOARS.
    Published • 10.1111/j.1365-2567.2009.03047.x
  38. Piteira, Ana Rita; Cabral, Maria Guadalupe; Ligeiro, Dário; Brossner, R; Videira, PA. "Dendritic cells show evidence of cell surface sialyltranferase (Abstract)". European Journal of Immunology suppl1/09 (2009): PA11/64-S366.
    Published
  39. Cabral, Maria Guadalupe; Ligeiro, Dário; Piteira, Ana Rita; Videira, Paula A.. "Specific endocytosis mechanisms of human dendritic cells are differently affected by sialic acid removal (Abstract)". European Journal of Immunology (2009):
    Published
  40. Videira, P.A.; Amado, I.F.; Crespo, H.J.; Algueró, M.C.; Dall'Olio, F.; Cabral, M.G.; Trindade, H.. "Surface a2-3- and a2-6-sialylation of human monocytes and derived dendritic cells and its influence on endocytosis". Glycoconjugate Journal 25 3 (2008): 259-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949126559&partnerID=MN8TOARS.
    Published • 10.1007/s10719-007-9092-6
  41. Pires, A.S.; Cabral, M.G.; Fevereiro, P.; Stoger, E.; Abranches, R.. "High levels of stable phytase accumulate in the culture medium of transgenic Medicago truncatula cell suspension cultures". Biotechnology Journal 3 7 (2008): 916-923. http://www.scopus.com/inward/record.url?eid=2-s2.0-48749092111&partnerID=MN8TOARS.
    Published • 10.1002/biot.200800044
  42. Crespo, Hélio J.; Cabral, Maria Guadalupe; Lopes, David; Trindade, Hélder; Videira, Paula A. "Dendritic Cells in mice with deficiency in sialyltransferases ST3Gal1 and ST6Gal1 (Abstract)". Journal of Glycobiology 17 11 (2007): PS3-23.
    Published
  43. Cabral, M. Guadalupe; Pires, Ana; Gonzalez-Melendi, Pablo; Abranches, Rita. "Characterization of Medicago truncatula cell suspension cultures producing valuable recombinant proteins (Abstract)". Microbial Cell Factories 5 Suppl 1 (2006): P92. http://dx.doi.org/10.1186/1475-2859-5-s1-p92.
    Open access • Published • 10.1186/1475-2859-5-s1-p92
  44. Viegas, C.A.; Cabral, M.G.; Teixeira, M.C.; Neumann, G.; Heipieper, H.J.; Sá-Correia, I.. "Yeast adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane fatty acid saturation degree and decreased OLE1 transcription". Biochemical and Biophysical Research Communications 330 1 (2005): 271-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-15444379378&partnerID=MN8TOARS.
    Published • 10.1016/j.bbrc.2005.02.158
  45. Papaefthimiou, C.; Cabral, M.D.G.; Mixailidou, C.; Viegas, C.A.; Sá-Correia, I.; Theophilidis, G.. "Comparison of two screening bioassays, based on the frog sciatic nerve and yeast cells, for the assessment of herbicide toxicity". Environmental Toxicology and Chemistry 23 5 (2004): 1211-1218. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542357157&partnerID=MN8TOARS.
    Published • 10.1897/03-48
  46. Cabral, M.G.; Sá-Correia, I.; Viegas, C.A.. "Adaptative responses in yeast to the herbicide 2-methyl-4- chlorophenoxyacetic acid at the level of intracellular pH homeostasis". Journal of Applied Microbiology 96 3 (2004): 603-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542329595&partnerID=MN8TOARS.
    Published • 10.1111/j.1365-2672.2004.02199.x
  47. Cabral, M.G.; Viegas, C.A.; Teixeira, M.C.; Sá-Correia, I.. "Toxicity of chlorinated phenoxyacetic acid herbicides in the experimental eukaryotic model Saccharomyces cerevisiae: Role of pH and of growth phase and size of the yeast cell population". Chemosphere 51 1 (2003): 47-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037400303&partnerID=MN8TOARS.
    10.1016/S0045-6535(02)00614-8
  48. Tenreiro, S.; Nunes, P.A.; Viegas, C.A.; Neves, M.S.; Teixeira, M.C.; Cabral, M.G.; Sá-Correia, I.. "AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae". Biochemical and Biophysical Research Communications 292 3 (2002): 741-748. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036086750&partnerID=MN8TOARS.
    Published • 10.1006/bbrc.2002.6703
  49. Cabral, Maria Guadalupe; Sá-Correia, Isabel; Viegas, CA. "Activation of plasma membrane H+-ATPase during latency induced by 2-methyl-4-chlorophenoxyacetic acid (MCPA) (Abstract)". 269 suppl1 (2002): 204.
    Published
  50. Cabral, M.G.; Viegas, C.A.; Sá-Correia, I.. "Mechanisms underlying the acquisition of resistance to octanoic-acid-induced-death following exposure of Saccharomyces cerevisiae to mild stress imposed by octanoic acid or ethanol". Archives of Microbiology 175 4 (2001): 301-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035035062&partnerID=MN8TOARS.
    Published • 10.1007/s002030100269
Thesis / Dissertation
  1. Cabral, Maria Guadalupe. "Avaliação da toxicidade e mecanismos de adaptação a herbicidas clorofenoxiacéticos: a levedura Saccharomyces cerevisiae como modelo experimental eucariótico.". PhD, Universidade de Lisboa Instituto Superior Técnico, 2004.
  2. Cabral, Maria Guadalupe. "Mecanismos de aquisição de tolerância ao ácido fraco conservante alimentar ácido octanóico na levedura Saccharomyces cerevisiae". Degree, Universidade de Lisboa Faculdade de Ciências, 1999.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/04 Personalizing immunotherapy for high-risk early-stage triple negative Breast cancer by targeting immunosuppressive neutrophils. X Jornadas de Investigação em Oncologia (Prémios Liga Portuguesa Contra o Cancro)
Liga Portuguesa Contra o Cancro (Lisbon, Portugal)
2024/11/07 Development of a microfluidic TIME-on-chip platform to evaluate novel strategies targeting pro-tumor neutrophils to ameliorate Breast Cancer treatments. NOVA Kick-Off Meeting
ITQB (Oeiras, Portugal)
2024/09/29 Exploring Immunosuppressive Neutrophils for the Personalization of Breast Cancer Treatments 2nd LS4Future PI Retreat
LS4Future (Vimeiro, Portugal)
2020/11/27 O valor preditivo e terapêutico dos linfócitos T citotóxicos que expressam HLA-DR, em cancro da mama. Jornadas da Investigação em Oncologia
Liga Portuguesa Contra o Cancro (Lisbon, Portugal)
2020/10/26 Mineral metabolism changes in renal transplanted patients XXXIV Congresso Português de Nefrologia
(Portugal)
2020/10/26 New bone-derived hormones, mineral metabolism, cardiovascular disease and patient survival in end-stage renal patients XXXIV Congresso Português de Nefrologia
(Portugal)
2020/10/09 Validation of cytotoxic T Lymphocytes expressing high levels of HLA-DR as a novel predictive biomarker of breast cancer patients’ response to neoadjuvant chemotherapy. II International Conference NOVAHealth Chronic disease and infection “Infection, Cancer and Global Health”
Universidade NOVA de Lisboa (Lisbon, Portugal)
2020/01 Sclerostin pre and after renal transplantation: a cohort analysis 3th European Renal Osteodystrophy (EUROD) winter meeting
(Leuven, Belgium)
2019/01/24 HLA-DR in cytotoxic T lymphocytes predicts breast cancer patients’ response to neoadjuvant chemotherapy. Unidade de Investigação em Patologia Molecular (UIPM) seminar cycles
Instituto Português de Oncologia de Lisboa (Lisbon, Portugal)
2018/11/30 Translating Breast Cancer Immune Features into putative Biomarkers: HLA-DR in Cytotoxic T Lymphocytes Predicts the Response to Neoadjuvant Chemotherapy. 3th World PreClinical Congress
(Lisbon, Portugal)
2018/10/19 HLA-DR in cytotoxic T lymphocytes is a predictive factor of breast cancer patients’ response to neoadjuvant chemotherapy 2nd NOVA Medical School Symposium - Translational Science and Healthcare Application at NOVA
NOVA Medical School Postdoctoral Comittee (Lisbon, Portugal)
2018/04 HLA-DR in cytotoxic and regulatory T cells dictates breast cancer aggressiveness and patient response to neoadjuvant chemotherapy. 25th Porto Cancer Meeting 2018: Cancer Wars:The immune Force awakens
i3S and IPATIMUP (Porto, Portugal)
2017/05/01 Immuno-Oncology: When cancer hijacks the immune system and brings it to the dark side of the Force Jornadas da Engenharia Biomédica
Universidade Lusófona de Humanidades e Tecnologia (Lisbon, Portugal)
2015/06 Glycoengineering Dendritic Cells for Immunotherapy Jornadas da Engenharia Biomédica
Universidade Lusófona de Humanidades e Tecnologias (Lisbon, Portugal)
2015 Antitumor and Anti-adhesion effect of a lectin isolated from the marine sponge Haliclona caerulia on the human breast cancer cell line MCF-7 . 11th International Meeting of the Portuguese Carbohydrate Group (GLUPOR) 6th Iberian Carbohydrate Meeting
(Viseu, Portugal)
2013/05 A snapshot over morphology and division of cultured Leishmania infantum parasites . Are these features important to access therapeutics activity over these parasites? Worldleish 5- Fifth World Congresso n Leishmaniosis.
(Porto Galinhas, Brazil)
2011/09/10 Desialylation improves the human dendritic cell phagocytic capacity. Glycoscience: Aplications to human and health and disease
(Lisbon)
2010/02/25 Sialic acid removal improves phagocytosis capacity of human dendritic cells. 44th Annual Scientific Meeting of European Society for Clinical Investigation. Workshop: Emerging aspects of phagocyte biology
(Bari, Italy)
2010 Enhanced sialylation of surface antigens on bladder cancer cell lines induces dendritic cell immune tolerance in vitro. V YES – Young European Scientis
(Porto, Portugal)
2007/09 a-2,3 and a-2,6 linked sialic acid at monocyte derived dendritic cells surface: endocytosis involvement. 7th International Meeting of Portuguese Carbohydrate Group (GLUPOR)
(Oeiras, Portugal)
2004 Assessment of herbicide toxicityand adaptative responses in Saccharomyces cerevisiae. XIV NationalCongress of Biochemistry,
(Vila Moura, Portugal)
2001 Toxic effects of chlorinated phenoxyacetic acid herbicides and 2,4-dichlorophenol in the eukaryotic model Saccharomyces cerevisiae. HERBICBIOREM Project Meeting
(Lisbon)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current PAPEL REGULATÓRIO DOS MACRÓFAGOS À RESPOSTA AO IMUNOTERÁPICO PEMBROLIZUMABE EM C NCER DE MAMA DO SUBTIPO LUMINAL B
Co-supervisor
 Mestrado em Genética (Master)
Fundação Universidade Federal do Mato Grosso do Sul Biblioteca, Brazil

Universidade Federal do Paraná, Brazil
2024 - Current Decoding the role of a new subset of Low-Density Neutrophils in Triple Negative Breast Cancer Progression and Immunotherapy Resistance
Supervisor
 Ciências da saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023 - Current Avaliação da atividade antitumoral de compostos sintéticos derivados do ácido cinâmico
Co-supervisor
 PhD (PhD)
Universidade Federal do Paraná, Brazil
2022/01/01 - Current “Identifying potential predictive and prognostic immune biomarkers in cutaneous melanoma”
Co-supervisor
 Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/10 - Current Exploring the antitumor effect of HLA-DR+ Cytotoxic T Lymphocytes in prognosis and treatment of Breast Cancer
Supervisor of Rute Salvador
Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - Current Differential molecular signature in patients from African origin with Triple-Negative Breast Cancer.
Supervisor of Ana Teresa Matias
 Ciências da Saúde (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - Current Renal Regeneration after an episode of Acute Kidney Injury
Supervisor of Sílvia Coelho
 Medicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/01 - 2024/01/12 Unveiling the role of the novel X-expressing neutrophils - chemokine axis in metastatic breast cancer
Supervisor
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/01/01 - 2021/02/17 Translating Breast Cancer Immune Features into Biomarkers and Therapies
Supervisor of Diana Saraiva
 Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - 2021/02 THE IMPACT OF IONIZING RADIATION ON MACROPHAGE IRON METABOLISM AND MACROPHAGE-CANCER CELL CROSSTALK
Co-supervisor
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - 2021/01/22 Unveiling the clinical relevance of low density neutrophils in Breast Cancer patients
Supervisor of Bruna Correia
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016 Estudo do processo apoptótico induzido em hospedeiros procariotas e eucariotas após infecção por bactérias do género Legionella.
Co-supervisor of Joana Dantas
 Microbiologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2013 Modulação das funções da Célula Dendrítica por variantes clonais de Burkholderia cenocepacia, isoladas de um doente com Fibrose Quística
Supervisor of Marília Pereira
Biologia Humana e Ambiente (Master)
2009 - 2010 Estudo da resposta imunológica desencadeada por células de cancro de bexiga que expressam antigénios sialyl-Tn
Co-supervisor of Mylène Carrascal
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2009 Identificação e Caracterização da Actividade de Sialiltransferase na Superfície Celular de Células Dendríticas
Co-supervisor of Ana Rita Piteira
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014/05/26 - 2014/05/30 EMBO workshop: Glycobiology and glycochemistry: Applications to human health and disease (2014/05/26 - 2014/05/30)
Workshop (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010/10 - 2010/10 Glycans in cell communication: what kind of science is Glycoscience? (2010/10 - 2010/10)
Workshop (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/03/26 - Current Round Table- Oportunidades e Desafios do Ecossistema Português para a Inovação em Saúde
Round table
 Laughing of Haddad NOVA Medical Innovation Center
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/16 Studying the role of Glycan-based biomarkers in cancer
(Thesis) Arguer
 Rita Adubeiro Lourenço (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/02/01 Exploring the role of low-density neutrophils as mediators of prognosis and treatment response in cancer
Supervisor
 Inês Brites (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02/17 Translating Breast Cancer Immune Features into potential Biomarkers and Therapies
Supervisor
 Diana P. Saraiva (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/12/07 Optimization of strategies for anti-cancer vaccines.
(Thesis) Main arguer
 Rita Severino dos Loios (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/12/18 HIV-1 infection on follicular helper T cells.
(Thesis) Main arguer
 Ana Raquel Lourenço de Sousa (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/10/31 Optimização de métodos de manipulação da expressão de genes em células primárias e tecidos.
(Thesis) Arguer
 Inês Raquel da Silvia Iria (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2013/11 Modulação das Funções da Célula Dendrítica por variantes clonais de Burkholderia cenocepacia, isoladas de um doente com Fibrose Quística.
Supervisor
 Marília Pereira (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 Cancro da Mama e Quimioterapia: O papel da via de Reparação de excisão de bases na resposta terapêutica
(Thesis) Main arguer
 Ana Carolina Dias Almeida (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 Efeito do tratamento com Tapsigargina nas Isomerases de Dissulfuretos de Melanoma
(Thesis) Main arguer
 Teresa Veríssimo (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Association member

Society Organization name Role
2007 - Current Portuguese Society of Immunology Member
2025 - 2025 ASPIC - Associação Portuguesa de Investigação em Cancro Member
2014 - 2016 European Society of Clinical Microbiology and Infectous Diseases Member

Committee member

Activity description
Role 		Institution / Organization
2024 - 2026 Member of the Infrastructures Scientific Committee of NOVA Medical School Research
Advisor / Consultant
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2015 Scientific Council of Biotechnology Engineering Master Course
Member
 Universidade Lusófona de Humanidades e Tecnologias, Portugal

Conference scientific committee

Conference name Conference host
2020 - 2022 Organization of XLVII SPI (Sociedade Portuguesa de Imunologia) Annual Meeting to be held on April 2022 CEDOC, NOVA Medical School, Faculdade de Ciências Médicas

Consulting

Activity description Institution / Organization
2018/02/03 - 2018/04/07 Visiting Scientist/Consultant Innovimmune Biotherapeutics, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/14 - Current Curricular Unit of Molecular Mechanisms of Diseases - Oncobiology Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/12 - Current The predictive and therapeutic value of HLA-DR-expressing Cytotoxic T lymphocytes in Breast Cancer - 2h lecture Biomedicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/06 - Current T cell functions in chronic inflammatory diseases - 2h lecture Ciências da Saúde (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/28 - Current Immunology, Aging and associated Chronic Desesas - 2h lecture for the module Aging and age-related diseases: from molecular mechanisms to therapies Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Exploring the immune microenvironment in Breast Cancer - 2h seminar for the module Research Seminars Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Immuno-Oncology - 2h lecture for the subject Clinical and Translational Oncology Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09 - Current Molecular and Cellular Biology Ciências da Nutrição (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/06/21 - Current Immuno-oncology: understanting the function and dysfunction of the immune system in cancer - 2h lecture for the module Advanced Therapies Engenharia Biomédica (Mestrado) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2011/12/01 - Current Tissues, Cells and Molecules Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2018 Genetic Engineering Engenharia Biotecnológica/Biologia (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2018 Immunology Engenharia Biotecnologica/Biologia (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2017/12/06 - 2017/12/06 Cancer and Immuno-Oncology - 3h lecture for the module Integrative Biomedicine Biomedicina (Doutoramento) Universidade de Aveiro, Portugal
2017/03/13 - 2017/03/17 Molecular Biology - 1 week full time course Graduated Program Science for Development (Doutoramento) Instituto Gulbenkian de Ciência, Portugal

Universidade de Cabo Verde, Cape Verde
2013 - 2017 General Genetics Engenharia Biotecnológica (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2017 Molecular Genetics Engenharia Biotecnológica/Biologia (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2016 Mechanisms of Diseases Biologia (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2014 - 2015 New methodologies of Laboratory Research Engenharia Biotecnológica (Mestrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2013 - 2015 Advanced Immunology Engenharia Biotecnológica (Mestrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2013 Molecular Biotechnology Engenharia Biotecnológica (Mestrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2010 - 2013 Fundamental of Genetic techniques analysis (Organizer and Lecturer) - 20h course Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2013 Introduction to confocal microscopy (Organizer and Lecturer) - 20h course Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007/09/01 - 2011/03/01 Immunology Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010/06 - 2010/07 Hematological Diseases Genética Clínica e Laboratorial (Especialização pós-licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009 - 2009 Molecular and Cellular Biology (Organizer and Lecturer) - 20h course Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003/09 - 2005/12 Microbiology and Parasitology (Diploma de especialização) Escola Superior de Biologia e Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2025/04 Interview - Cancro: uma nova esperança… LuxWomen
2025/04 Contribution to the article: O Cancro da mama não escolhe idades Women's Health
2023/11/27 Cancro da mama: novos alvos, novos tratamentos? Observador
2021/09/22 Biomarcador determina eficácia da quimioterapia. Objetivo: "Menos doentes submetidos a um tratamento, sem clara vantagem" Sabado.pt
2019/11 "O que nos dizem um gene sobre o autismo e os linfócitos sobre o cancro da mama?" Publico
2019/11 Pfizer 2019 distingue investigação sobre autismo e cancro da mama Notícias ao minuto
2019/11 Prémios Pfizer: projetos vencedores contribuem para a investigação sobre o autismo e o cancro da mama News Phama Online
2019/11 Prémios Pfizer 2019 para investigação sobre autismo e cancro da mama Diário de notícias on line
2019/05 "Novas Fronteiras no Cancro da Mama" Frontal, 49th Edition dedicated to the theme "A mulher e a Medicina"
2019/03/18 "Análises detetam se doentes com cancro da mama vão ter boa resposta à quimioterapia" Diário de Notícias

Interview (tv / radio show)

Program Topic
2024/03/17 - Current Antena2Ciência Aumentar eficácia da imunoterapia no tratamento do cancro da mama

Mentoring / Tutoring

Topic Student name
2019 - Current Evaluation of the therapeutic potential of immunotherapy with dendritic cells in combination with immune checkpoints blockade. Danielle Almeida
2019 - Current Regulation of pulmonary CD4 T cell responses to Mycobacterium tuberculosis infection. Catarina Ferreira
2019 - Current Clinical decision method for surgical treatment of Hepatocellular Carcinoma: clinical and technical validation study. Sara Carapeta
2018 - Current Primary resistance mutations in HIV-infected pregnant women associated with vertical transmission in Lucrécia Paím Maternity during the second trimester of 2018. Cruz dos Santos Sebastião
2007 - Current Scientific short traineeships - Exchange Program for Medical Students Several medical students from abroad
2015 - 2016 PhD thesis: Prospeção e aplicação de lectinas vegetais e de algas marinhas e metabolitos bioativos de plantas da flora brasileira na cicatrização de feridas agudas e crónicas (Collaboration with Universidade do Ceará) Luís do Nascimento Neto
2007 - 2012 Responsible for Young students Scientific Occupation in Holydays: Ciência Viva Program Several undergraduate students
2011/01 - 2011/02 Lab rotation: O papel immunomodulatório de glicanos sialilados nas funções das células dendríticas humanas (PhD program: Envelhecimento e Degenescência de Sistemas Biológicos Complexos,) Sandro Mesquita
2010 - 2011 Master Thesis: Insights into the mechanisms of immune escape of Burkholderia cepacia complex bacteria isolated from cystic fibrosis patients. (Program: Mestrado em Genética Molecular e Biomedicina da Faculdade de Ciências e Tecnologia, UNL) Andreia Lopes
2010 - 2011 Master thesis: Estudo do Efeito antitumoral de pró-fármacos de triazenos em linhas celulares de melanoma (Mestrado em Análises Clínicas da Universidade de Lisboa, Faculdade de Farmácia) Joana Almeida
Distinctions

Award

2024 Research Grant
Liga Portuguesa Contra o Cancro, Portugal
2024 Research Grant - Gilead Génese
Gilead Sciences Lda, Portugal
2023 CaixaImpulse Innovation
Caixa d'Estalvis i Pensions de Barcelona, Spain
2019 Liga Portuguesa Contra o Cancro/Terry Fox research grant 2019
Liga Portuguesa Contra o Cancro, Portugal
2019 Pfizer/Sociedade das Ciências Médicas de Lisboa - Clinical Investigation Prize 2019
Pfizer Portugal, Portugal

Sociedade das Ciências Médicas, Portugal
2018 Research Projects in Medicine Prize 2018
Tagus Tank Consortium, Portugal
2010 Best Research Work
Banco Espírito Santo e Comercial de Lisboa, Portugal

Other distinction

2020 Scicare – Novartis Health Science Accelerator Program
Novartis Farma SA, Portugal
2018 2 month fellowship for a scientific/consultant visit to a Biotech company in USA
Innovimmune Biotherapeutics, United States
2010 Travel grant
European Society for Clinical Investigation, Netherlands
2009 1st Poster Prize
Sociedade Ibérica de citometria de fluxo, Spain
2007 Travel grant
Fundação Calouste Gulbenkian, Portugal
2005 Post-Doc Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2003 Travel grant
Fundação Calouste Gulbenkian, Portugal
1999 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1999 Research Grant
PRODEP, Portugal