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Nair Nazareth graduated in Microbiology at Faculty of Biotechnology of the Catholic University of Portugal (2003) and she obtained her PhD in Metabolism - Clinical and Experimental at Faculty of Medicine of University of Porto (2014). Currently, she is a research fellow of Liga Portuguesa Contra o Cancro - Núcleo Regional do Norte and a researcher at LAQV/REQUIMTE/DRUG DISCOVERY & DEVELOPMENT RESEARCH UNIT (3DUnit) at the Faculty of Pharmacy of the University of Porto (FFUP), aiming to identify and validate new targeted-anticancer therapies under the supervision of Prof. Lucília Saraiva. She intends to uncover new pharmacological opportunities in skin cancer prevention by targeting p53. Published 24 articles in international peer-reviewed journals and has 1 book chapter. Participates and/or participated as Research Fellow in 3 financed projects. She works in Medical and Health Sciences field, with emphasis on Pharmacology and Oncobiology. In her professional activities interacted with 98 collaborators co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: Cancer; Oncobiology; Biomedicine; Targeted-anticancer therapies; Pharmacology; Cancer chemotherapy; Cancer chemoprevention; p53.
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Identification

Personal identification

Full name
Nair Alexandra Barbosa Nazareth Campos

Citation names

  • Nazareth, Nair

Author identifiers

Ciência ID
CA17-881A-868F
ORCID iD
0000-0001-6297-4773

Addresses

  • Rua Jorge Viterbo Ferreira, nº228,, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2014/12/04
Concluded
 Metabolismo - Clínica e Experimentação (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Macrophage-mycobacterium avium SPP paratuberculosis interplay in inflammatory bowel diseases: possible immunopathological implications." (THESIS/DISSERTATION)
2003/12
Concluded
 Microbiologia (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2018 - Current Researcher (Research) Universidade do Porto Faculdade de Farmácia, Portugal
2009 - 2012 Researcher (Research) Universidade Fernando Pessoa - Faculdade de Ciências da Saúde, Portugal
2005 - 2008 Researcher (Research) Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2020/01/01 - 2020/12/31 Bolseiro Investigação Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2020/01/01 - 2020/12 Uncovering new pharmacological opportunities in skin cancer prevention by targeting p53
LPCC-NRN 2020
Research Fellow
Universidade do Porto Faculdade de Farmácia, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Ongoing
2009 - 2012 Infecção micobacteriana e Doença de Chron
PIC/IC/82802/2007
Research Fellow
Universidade Fernando Pessoa, Portugal
 Fundação para a Ciência e a Tecnologia
2005 - 2008 Caracterização e Avaliação da Actividade Antitumoral de Compostos Bioactivos de Esponjas Marinhas
POCI/MAR/58114/2004
Research Fellow
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Campos, Nair; Sarmento, Amélia; Appelberg, Rui; Magro, Fernando. "Defective Macrophage Function in Crohn's Disease". 345-358. 2012.
Conference abstract
  1. Raimundo, Liliana; Sousa, Emilia; Saraiva, Lucília; Gomes, Sara; Soares, Joana; Loureiro, Joana; Leão, Mariana; et al. "Targeting neuroblastoma with a new inhibitor of the TAp73 interaction with MDM2 and mutant p53". 2019.
    10.3390/ecmc2019-06305
  2. Nazareth, Nair. "Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions". 2019.
    10.3390/ecmc2019-06306
Journal article
  1. Nazareth, Nair. "Cytotoxicity of Frutalin on Distinct Cancer Cells Is Independent of Its Glycosylation". Molecules 26 16 (2021): 4712-4712. http://dx.doi.org/10.3390/molecules26164712.
    10.3390/molecules26164712
  2. Nazareth, Nair. "Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity.". Molecules (Basel, Switzerland) (2020):
    10.3390/molecules25071578
  3. Campos, Nair. "SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma". (2019):
    10.3390/cancers11081151
  4. Silva, Viviana; Cerqueira, Fátima; Nazareth, Nair; Medeiros, Rui; Sarmento, Amélia; Sousa, Emília; Pinto, Madalena. "1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity". Pharmaceuticals 12 2 (2019): 85. http://dx.doi.org/10.3390/ph12020085.
    10.3390/ph12020085
  5. Moreira, Joana; Ribeiro, Diana; Silva, Patrícia; Nazareth, Nair; Monteiro, Madalena; Palmeira, Andreia; Saraiva, Lucília; et al. "New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation". Molecules 24 1 (2018): 129. http://dx.doi.org/10.3390/molecules24010129.
    10.3390/molecules24010129
  6. Campos, Nair. "Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease". Med Microbiol Immunol (2015):
    10.1007/s00430-015-0420-3
  7. Campos, Nair. "Increased viability but decreased culturability of Mycobacterium avium subsp. paratuberculosis in macrophages from inflammatory bowel disease patients under Infliximab treatment". Med Microbiol Immunol (2015):
    10.1007/s00430-015-0393-2
  8. Nazareth, N.; Magro, F.; Silva, J.; Duro, M.; Gracio, D.; Coelho, R.; Appelberg, R.; Macedo, G.; Sarmento, A.. "Infliximab therapy increases the frequency of circulating CD16+monocytes and modifies macrophage cytokine response to bacterial infection". Clinical & Experimental Immunology 177 3 (2014): 703-711. http://dx.doi.org/10.1111/cei.12375.
    10.1111/cei.12375
  9. Campos, Nair. "Epstein-Barr virus in inflammatory bowel disease – correlation with different therapeutic regimens". Inflamm Bowel Dis (2013):
    10.1097/MIB.0b013e318281f31c
  10. Campos, Nair; Magro, Fernando; Castro, Ana Rita; Cabral, Joana; Rodrigues, Pedro; Silva, Ricardo; Appelberg, Rui; et al. "Macrophages from IBD patients exhibit defective tumour necrosis factor-a secretion but otherwise normal or augmented pro-inflammatory responses to infection". Immunobiology 216 8 (2011): 961-970. http://dx.doi.org/10.1016/j.imbio.2011.01.002.
    10.1016/j.imbio.2011.01.002
  11. Pinto, Orlando; Sardinha, Joa~o; Vaz, Pedro D.; Piedade, Fa´tima; Calhorda, Maria J.; Abramovitch, Rudolph; Nazareth, Nair; et al. "Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethylp-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of Human Tumor Cell Lines". Journal of Medicinal Chemistry 54 9 (2011): 3175-3187. http://dx.doi.org/10.1021/jm101182s.
    10.1021/jm101182s
  12. Costa, Elisangela; Sousa, Emilia; Nazareth, Nair; S.J. Nascimento, Maria; M.M. Pinto, Madalena. "Synthesis of Xanthones and Benzophenones as Inhibitors of Tumor Cell Growth". Letters in Drug Design & Discovery 7 7 (2010): 487-493. http://dx.doi.org/10.2174/157018010791526250.
    10.2174/157018010791526250
  13. Sousa, Emília; Paiva, Ana; Nazareth, Nair; Gales, Luis; Damas, Ana M.; Nascimento, Maria S.J.; Pinto, Madalena. "Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines". European Journal of Medicinal Chemistry 44 9 (2009): 3830-3835. http://dx.doi.org/10.1016/j.ejmech.2009.04.011.
    10.1016/j.ejmech.2009.04.011
  14. Castanheiro, Raquel; Silva, Artur; Campos, Naïr; Nascimento, Maria; Pinto, Madalena. "Antitumor Activity of Some Prenylated Xanthones". Pharmaceuticals 2 2 (2009): 33-43. http://dx.doi.org/10.3390/ph2020033.
    10.3390/ph2020033
  15. Castanheira, Elisabete M.S.; Abreu, Ana S.; Queiroz, Maria-João R.P.; Ferreira, Paula M.T.; Coutinho, Paulo J.G.; Nazareth, Nair; Nascimento, M. São-José. "Fluorescence properties of a potential antitumoral benzothieno[3,2-b]pyrrole in solution and lipid membranes". Journal of Photochemistry and Photobiology A: Chemistry 206 2-3 (2009): 220-226. http://dx.doi.org/10.1016/j.jphotochem.2009.07.007.
    10.1016/j.jphotochem.2009.07.007
  16. Kijjoa, Anake; Gonzalez, Maria; Pinto, Madalena; Nascimento, Maria; Campos, Nair; Mondranondra, Ing-On; Silva, Artur; Eaton, Graham; Herz, Werner. "Cytotoxicity of Prenylated Xanthones and Other Constituents from the Wood ofGarcinia merguensis". Planta Medica 74 08 (2008): 864-866. http://dx.doi.org/10.1055/s-2008-1074544.
    10.1055/s-2008-1074544
  17. Queiroz, Maria-João R.P.; Abreu, Ana S.; Carvalho, M. Solange D.; Ferreira, Paula M.T.; Nazareth, Nair; São-José Nascimento, M.. "Synthesis of new heteroaryl and heteroannulated indoles from dehydrophenylalanines: Antitumor evaluation". Bioorganic & Medicinal Chemistry 16 10 (2008): 5584-5589. http://dx.doi.org/10.1016/j.bmc.2008.04.004.
    10.1016/j.bmc.2008.04.004
  18. Gupta, Sanjay; Rodrigues, Lígia M.; Esteves, Ana P.; Oliveira-Campos, Ana M.F.; Nascimento, M. São José; Nazareth, N.; Cidade, Honorina; et al. "Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors". European Journal of Medicinal Chemistry 43 4 (2008): 771-780. http://dx.doi.org/10.1016/j.ejmech.2007.06.002.
    10.1016/j.ejmech.2007.06.002
  19. Benites, Julio; Valderrama, Jaime A.; Rivera, Felipe; Rojo, Leonel; Campos, Nair; Pedro, Madalena; José Nascimento, María Säo. "Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines". Bioorganic & Medicinal Chemistry 16 2 (2008): 862-868. http://dx.doi.org/10.1016/j.bmc.2007.10.028.
    10.1016/j.bmc.2007.10.028
  20. Campos, Nair. "Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines". Pharmaceutical Biology (2007):
    10.1080/13880200701501300
  21. Campos, Nair. "Dihydroxyxanthones prenylated derivatives: Synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7". Bioorg Med Chem (2007):
    10.1016/j.bmc.2007.06.037
  22. Oliveira, Ana M. A. G.; Oliveira-Campos, Ana M. F.; Rodrigues, Lígia M.; Raposo, M. Manuela M.; Machado, Antonio E. H.; Nascimento, M. São José; Nazareth, N.; Pinto, Madalena. "Synthesis and Antitumor Evaluation of Benzopsoralen Analogues". Chemistry & Biodiversity 4 5 (2007): 980-990. http://dx.doi.org/10.1002/cbdv.200790089.
    10.1002/cbdv.200790089
  23. Campos, Nair. "Anticancer activity evaluation of Kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand". Mar Drugs (2007):
  24. Campos, Nair. "An unusual glucoside from Cleistanthus gracilis". Phytochemistry (2006):
    10.1016/j.phytochem.2006.01.014
  25. Campos, Nair. "Cytotoxicity and inhibition of lymphocyte proliferation of fasciculatin, a linear furanosesterterpene isolated from Ircinia variabilis collected from the Atlantic Coast of Morocco". Mar Drugs (2005):
    10.3390/md301015
Thesis / Dissertation
  1. Nair Alexandra Barbosa Nazareth Campos. "Macrophage-mycobacterium avium SPP paratuberculosis interplay in inflammatory bowel disease: possible immunopathological implications.". PhD, 2014. http://hdl.handle.net/10216/96544.

Other

Other output
  1. Mycobacterium avium subsp paratuberculosis detection from blood of Crohn's disease patients in a portuguese hospital. Mycobacterium avium subsp paratuberculosis (MAP) has been associated with Crohn’s disease (CD). We performed MAP DNA detection in the blood of controls and CD patients followed at Hospital de São João, by IS900-based nested PCR. We found that 60% (6 out of 10) of CD patients were positive for MAP DNA, against 38% (8 out of 21) of control subjects. MAP detection in CD patients will allow us to corr. 2010. Martinho, António; Campos, Nair; Rodrigues, Pedro; Magro, Fernando; Sarmento, Amélia. http://hdl.handle.net/10284/2995.
  2. Mycobacterium avium SPP. Paratuberculosis up-regulates CD40 expression and down-regulates IL-10 production by human macrophages. Mycobacterium avium spp paratuberculosis (MAP) tem vindo a ser sugerido como um agente etiológico da doença de Crohn. Este estudo teve por objectivo avaliar os efeitos imunomoduladores do MAP em macrófagos humanos. Os macrófagos foram obtidos a partir do sangue de controlos normais ou pacientes com doença de Crohn, e infectados in vitro com MAP ou Mycobacterium avium spp. avium (MA). Os efeitos ob. 2009. Campos, Nair; Castro, Ana Rita; Cabral, Joana; Bacalhau, Nicole Marques; Magro, Fernando; Sarmento, Amélia. http://hdl.handle.net/10284/1266.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/05 New Inhibitor of the BRCA1-BARD1 interaction with anticancer activity in BRCA-1-deficient breast and ovarian cancers SPF Meeting 2020
(Coimbra, Portugal)
2019/02/13 UPC-53: A promising mutant p53 reactivator with in vivo antitumor activity IJUP19
(Porto, Portugal)
2013/01/18 Epstein-Barr virus in inflammatory bowel disease: correlation with different therapeutic regimens Reunião Anual GEDII 2013 – Factores de Prognóstico na Doença Inflamatória Intestinal
(Porto, Portugal)
2011/12/14 Mycobacterium avium subsp. paratuberculosis prevalence in portuguese inflammatory bowel disease patients according to disease activity 1º ED-FMUP
(Porto, Portugal)
2011/06/26 Crohn’s disease and mycobacterium avium subsp paratuberculosis prevalence in a Portuguese cohort 32nd Annual Congress of the ESM
(Lubeck, Germany)
2010/10/23 Mycobacterium avium subsp paratuberculosis is present in the blood of Crohn’s disease patients and can modulate macrophage activity 18th UEGW
(Barcelona, Spain)
2010/06/09 Macrófagos de pacientes com IBD apresentam secreção diminuída de TNF-alfa mas são capazes de induzir inflamação como resposta a infecção bacteriana XXX Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
(Vilamoura, Portugal)
2007/08/05 Prenylation of 1,3-dihydroxy-2-methylxanthone: Improvements on the growth inhibitory activity against MCF-7 cell line 41st IUPAC World Chemistry Congress
(Turin, Italy)
2004/10/03 Cytotoxic Evaluation of Eight Furylquinones and Hidroquinones XXVI Annual Meeting of Chilean Society of Pharmacology – IUPHAR / Quinamavida
(Quinamavida, Chile)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/07/08 - 2019/07/12 Organisation of the advanced training course: Model organisms in human disease: the right model for a specific question (Outros) Universidade do Porto Faculdade de Farmácia, Portugal