Cláudia Guimas Almeida (CA10-FD1E-99FD)

Curriculum Vitae

Cláudia Guimas Almeida

I am a research group leader at NOVA Medical School in Lisbon, Portugal, committed to advancing the understanding of Alzheimer's disease (AD), specializing in dissecting AD molecular and cellular underpinnings, focusing on synaptic dysfunction, endocytic trafficking defects, and the pivotal role of genetic risk factors in these processes. I earned a bachelor's degree in Biochemistry in 1999. I became fascinated with the brain, thus pursuing a master's degree in neuroscience (2001) and a Ph.D. in the same field (2007) from the University of Lisbon. During my doctoral research at the prestigious Weill Medical College of Cornell University in New York, I gained important insights into beta-amyloid-dependent synaptic and endosomal dysfunction, which laid the groundwork for my future work on AD. I realized the significance of endosomal trafficking for synapses, so I pursued training as a cell biologist as an EMBO and Marie Curie postdoctoral fellow at the Institut Curie in Paris (2007-2012). After the birth of my second son, I began grant writing and job hunting before starting an independent research group at NOVA Medical School in 2013, combining my knowledge of AD with my cell biological training. I have been supported by the Portuguese Science Foundation (FCT), first by being selected internationally as a starting Investigator FCT and then as an Auxiliary Investigator (CEEC Ind 2017). In 2022, I was selected as Principal Investigator of iNOVA4Health, a translational medicine research unit. I secured funding and fellowships (more than 1 million euros) for the lab from the national FCT, the European Commission, and the American Alzheimer's Association and received several awards. I have also become involved in undergraduate and postgraduate teaching, co-coordinate a master's in biomedical research, and won a teaching award. I also steer the scientific community by co-organizing local and national meetings and globally have been involved in AD research leadership for 20 years through Alzforum.org, invited to the top conferences (from the USA to Chile). I have made groundbreaking discoveries, including the role of beta-amyloid in AD and the involvement of actin dynamics and myosin1b in cargo exit from the trans-Golgi Network. My team has identified the impact of two Alzheimer's disease risk factors, Bin1 and CD2AP, on beta-amyloid accumulation and synapse dysfunction. Our research has advanced knowledge and opens new avenues for Alzheimer's disease therapy.

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Identification

Personal identification

Full name: Cláudia Guimas Almeida

Citation names

Guimas Almeida, Claudia
Almeida, Claudia G.

Author identifiers

Ciência ID: CA10-FD1E-99FD
ORCID iD: 0000-0001-9384-2896
Google Scholar ID: https://scholar.google.com/citations?user=7sb3PWYAAAAJ&hl=en
Scopus Author Id: 57303082300

Addresses

NOVA Medical School - Universidade NOVA de Lisboa. Campo Mártires da Pátria, 130, 1169-056 , Lisboa, Lisboa, Portugal (Professional)

Websites

https://www.nms.unl.pt/en-us/research/research-groups/research-group/n/neuronal-trafficking-in-aging (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Portuguese (Mother tongue)
French	Elementary (A2)	Upper intermediate (B2)	Intermediate (B1)	Intermediate (B1)	Elementary (A2)

Education

	Degree	Classification
2024 Concluded	Bioquímica e Biomedicina (Mestrado) Major in Sem especialização Universidade de Lisboa Faculdade de Ciências, Portugal "Investigating the Late-Alzheimer´s disease phenotype of CD2AP genetic risk in induced human neurons" (THESIS/DISSERTATION)
2022 Concluded	Ciências da Saúde (Doutoramento) Major in Especialidade: Biomedicina Universidade Nova de Lisboa Medical School, Portugal "Understanding the Impact of Late-onset Alzheimer’s Disease Mutations in CD2AP on Synapses" (THESIS/DISSERTATION)
2022 Concluded	Investigação Biomédica (Mestrado) Major in Área de especialização: Medicina Regenerativa Universidade Nova de Lisboa Medical School, Portugal "Uncovering the mechanism of CD2AP behind Alzheimer¿s disease" (THESIS/DISSERTATION)
2021 Concluded	Ciências da Saúde (Doutoramento) Major in Especialidade: Biomedicina Universidade Nova de Lisboa Medical School, Portugal "Breaking BIN1: Investigating mechanisms of synaptic dysfunction in Alzheimer’s disease" (THESIS/DISSERTATION)
2019 Concluded	Genética Molecular e Biomedicina (Mestrado) Major in Sem especialização Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Understanding the impact of sporadic Alzheimer´s disease mutations on BIN1 " (THESIS/DISSERTATION)
2018 Concluded	Genética Molecular e Biomedicina (Mestrado) Major in Sem especialização Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer’s Disease " (THESIS/DISSERTATION)
2017 Concluded	Mecanismos de Doença e Medicina Regenerativa (associação) (Doutoramento) Major in Sem especialidade Universidade Nova de Lisboa Medical School, Portugal "Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer’s disease" (THESIS/DISSERTATION)
2017 Ongoing	Bioengenharia (Doutoramento) Major in Especialidade: Bioengenharia - Terapias Celulares e Medicina Regenerativa Universidade de Lisboa Instituto Superior Técnico, Portugal "The impact of the genetic risk factor Bin1 to Alzheimer’s disease development" (THESIS/DISSERTATION)
2015 Concluded	Investigação Biomédica (Mestrado) Major in Sem especialização Universidade de Coimbra Faculdade de Medicina, Portugal "Endocytic trafficking mechanisms in Alzheimer´s disease: role of the actin regulators bin l and CD2AP" (THESIS/DISSERTATION)
2014 Concluded	Biologia Molecular e Genética (Mestrado) Major in Sem especialização Universidade de Lisboa Faculdade de Ciências, Portugal "Identification of the cellular and molecular mechanism by which CD2AP, a regulator of neuronal intracellular transport contributes to the development of Alzheimer’s disease" (THESIS/DISSERTATION)
2014 Concluded	Genética Molecular e Biomedicina (Mestrado) Major in Sem especialização Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Bridging intrgrator 1 (BIN1) contrls beta-amyloid accumulation in Alzheimer s disease" (THESIS/DISSERTATION)
2007 - 2012 Concluded	Post-doc in Cell Biology (Pós-doutoramento) Institut Curie, France
2002 - 2007 Concluded	Biomedical Sciences- Basic Neurosciences (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal Weill Medical College of Cornell University, United States "beta-amyloid-dependent neuronal dysfunction and effect on the endocytic pathway" (THESIS/DISSERTATION)
1999 - 2002 Concluded	Neurosciences (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal "Adenosine promotes the neuronal recovery from the reactive oxygen species induced lesion" (THESIS/DISSERTATION)
1994 - 1999 Concluded	Biochemistry (Licenciatura) Faculdade de Cências da Universidade de Lisboa, Portugal "Alterations in bile acids and bilirubin levels in hepatic disease and studies on bilirubin-induced phosphatidylserine externalization in the membrane of human erythrocytes" (THESIS/DISSERTATION)

Affiliation

Science

	Category Host institution	Employer
2013/04/01 - Current	Principal Investigator (Research)	Universidade Nova de Lisboa, Portugal
	Universidade NOVA de Lisboa NOVA Medical School, Portugal (...)
2018 - 2022	Invited Auxiliary Researcher (Research)	Marine Biological Laboratory, United States
	Marine Biological Laboratory, United States
2007/03 - 2012/02	Researcher (Research)	Institut Curie, France

2002/03 - 2007/02	Researcher (Research)	Weill Medical College of Cornell University, United States

Teaching in Higher Education

	Category Host institution	Employer
2018 - 2019	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal

2018 - 2019	Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal

2016 - 2018	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal

2016 - 2018	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal

Projects

Grant

	Designation	Funders
2023/09/01 - Current	FCT LA LS4Future: Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 10.54499/LA/P/0087/2020 Researcher Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal Universidade Nova de Lisboa, Portugal GREEN-IT, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017 - Current	FCT UID: iNOVA4Health - Programa de Medicina Translacional iBET, CEDOC/FCM, IPOLFG e ITQB UID/Multi/04462/2019 Researcher Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal iNOVA4Health, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024/11 - 2027	CaixaResearch: Early detection of neurodegenerative diseases through the study of tau protein aggregates LCF/PR/HR24/52440012 Researcher Universidade Nova de Lisboa, Portugal	Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa' Ongoing
2024 - 2027	Horizon Europe: Twinning MPS_NOVA European Hub of Excellence in Microphysiological Systems (MPS) (GA 101159729). HORIZON-WIDERA-2023-ACCESS-02-01 Researcher	Horizon 2020 Ongoing
2022 - 2025	Horizon Europe Twinning: Centre for Excellence in Diagnostic and Advanced Therapeutics based on Extracellular Vesicles (EVCA) Horizon GA nº 101079264 Researcher Universidade NOVA de Lisboa NOVA Medical School, Portugal	Horizon 2020 Ongoing
2022 - 2024	Alzheimer's Association rapid funding (USA) AARG-19-618007-RAPID Principal investigator Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Alzheimer's Association Concluded
2019/01 - 2024	Alzheimer's Association grant (USA) 2168 Principal investigator Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Alzheimer's Association Concluded
2018/10/01 - 2022/06/30	FCT project: Lysosome dysfunction in age-related diseases PTDC/MED-PAT/30385/2017 Researcher Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022/04	H2020 Twinning: Excel in Rare Diseases Research: Focus on Lysosomal Disorders and Ciliopathies (LYOSOCIL) H2020-TWINN-2017-811087 Researcher Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation Concluded
2016/06 - 2020/05	JPND/H2020: Development of a Novel Multicellular In Vitro Model of Alzheimer's disease-like Blood-Brain Barrier JPCOFUND/0004/2015 - NAB3 Researcher Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017 - 2019	FCT UID INOVA4Health Seed project: Do genetic variants in CD2AP increase the risk of developing Alzheimer's disease? iNOVA4Health/2017/40 Principal investigator Universidade NOVA de Lisboa NOVA Medical School, Portugal	iNOVA4Health Concluded
2013/04 - 2017/03	Marie Curie Integration grant: Traffic in AD. 334366 Principal investigator Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	European Commission Concluded
2002/02/01 - 2006/01/31	OXIDATIVE STRESS AND NEURONAL BETA-AMYLOID ACCUMULATION SFRH/BD/6270/2001 Universidade de Lisboa Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001/02/01 - 2002/01/31	A LESÃO E MORTE NEURONAL. UMA AVALIAÇÃO ELECTROFISIOLÓGICA SFRH/BM/2096/2000 Universidade de Lisboa Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2022/12/15 - Current	Principal Investigator R&D FCT iNOVA4Health UID/Multi/04462/2019 Principal investigator iNOVA4Health, Portugal Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/03 - 2022/10	Auxiliar Investigator CEECIND/00410/2017/CP1421/CT0001 CEECIND/00410/2017 Principal investigator Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/05/15 - 2018/05/14	Investigator FCT (Starting iFCT) IF/00998/2012/CP0182/CT0004 Provided by PTCRIS: 147476 Principal investigator Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Medical School, Portugal	Fundação para a Ciência e a Tecnologia Secretaria de Estado de Ciência Tecnologia e Ensino Superior Concluded

Outputs

Publications

Book chapter	"Age-related diseases: common mechanisms and therapeutic approaches". In In "Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata, 246-259. Universidade Nova de Lisboa and Fundação Amélia de Mello, 2021. Published
Conference abstract	Guimas Almeida, Claudia; Barata, Mariana; Perdigão, Catarina; Ramalho, Jose. "Bin1 regulates synaptic endocytic trafficking compromised by Alzheimer’s genetic risk variants". Paper presented in Alzheimer's & Dementia: Alzheimer's Association International Conference 2024 (AAIC), Philadelphia, 2024. Guimas Almeida, Claudia; Burrinha, Tatiana. "Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis.". Paper presented in FENS Virtual Forum, 2021. Mirfakhar, farzaneh. "Alzheimer's disease risk factor CD2AP functions at synapses via spinal F-actin". Paper presented in 2021 Alzheimer's Association International Conference, 2021. Published • https://doi.org/10.1002/alz.043900 "Lysosomal subcellular distribution in neurons: are there synaptic lysosomes?". Paper presented in 2021 Alzheimer's Association International Conference, 2021. Burrinha, Tatiana. "Upregulation of APP Endocytosis by Neuronal Aging Drives Amyloid-Dependent Synapse Loss". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021. Araújo, Margarida. "Actin Controls APP Endosomal Sorting: Implications for Alzheimer's Disease". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021. Cunha, César; Burrinha, Tatiana. "Disclosing lysosomal dysfunction in cortical neuronal aging: a promising driver of early synaptic degeneration in Alzheimer’s Disease". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021. Guimas Almeida, Claudia; Perdigão, Catarina; Barata, Mariana Afonso. "Alzheimer's disease variants in the genetic risk factor BIN1 increase Beta-Amyloid accumulation by decreasing Bace1 recycling". Paper presented in FENS Virtual Forum 2020, 2020. Mirfakhar, farzaneh; Guimas Almeida, Claudia. Corresponding author: Guimas Almeida, Claudia. "The late-onset Alzheimer's disease genetic risk factor CD2AP impacts synapses via actin dynamics: Basic science and pathogenesis: Genetics and omics of AD". Paper presented in 2020 Alzheimer's Association International Conference - Journal Alzheimer's & Dementia, 2020. https://doi.org/10.1002/alz.043900 Figueira, Inês; Salavessa, Laura; Oliveira, Luís; Guimas Almeida, Claudia. "Actin as a key player in the control of neuronal endosomal sorting: implications for Alzheimer's disease". Paper presented in ADPD2019, Lisboa, 2019. Published Almeida, Claudia G. "EHD proteins mediate ubiquitin-dependent recycling of gap junctions (GJs) in the ischemic heart". 2019. Almeida, Claudia G. "P2286 EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia". Paper presented in European Heart Meeting, 2018. Almeida, Claudia G; Salavessa, Laura Nunes Soares Sequeira. "Actin control of endosomal sorting in neurons: impact on Alzheimer's disease.". Paper presented in ASCB/EMBO, 2017. Almeida, Claudia G. "P4-260: Intraneuronal Aß42 and microtubule-associated protein pathologies begin in synapses". Paper presented in AAIC, 2008. Zhang, Q; Gerratana, L; Zhang, Y; Flaum, L; Shah, A; Davis, A; Behdad, A; et al. "P4-041: The Arctic Alzheimer mutation favors Aß production by making APP less available to a-secretase at the cell surface". Paper presented in Alzheimer Association International meeting, 2006. 10.1158/1538-7445.sabcs18-p4-01-04 Almeida, Claudia G. "P4-050: Endogenous Abeta42 accumulation in neurons impairs the multivesicular body sorting pathway". Paper presented in Alzheimer 's Association International meeting, 2006. Almeida, Claudia G. "O4-06-08: Internalized antibodies to the Aß domain of APP reduce intraneuronal Aß and protect against synaptic alterations". Paper presented in AAIC, 2006. Almeida, Claudia G. "P3-322 Altered expression of synaptic and immediate early genes in a neuronal culture model of Alzheimer's disease". 2004. Almeida, Claudia G. "P3-313 Significance of intraneuronal Aß accumulation in Alzheimer's disease". 2004. Almeida, Claudia G. "O4-02-04 The arctic APP mutation affects Aß production and its site of cellular aggregation in Alzheimer's disease". 2004. Published Almeida, Claudia G. "P3-314 Aß42 accumulation in endosomes is associated with synaptic alterations". 2004. Almeida, Claudia G. "P1-195 Oligomerization of Alzheimer's Aß within processes and synapses of cultured neurons and brain". 2004. Almeida, Claudia G. "Beta-amyloid accumulation in late endosomes/MVBs in cultured neurons is associated with alterations in endocytosis". Paper presented in ASCB, 2004.
Conference poster	Carnicero-Senabre, Daniel; Barata, Mariana Afonso; Guimas Almeida, Claudia; Rojo, Ana. "Defining the role of the NRF2 transcription factor in synaptic maintenance in Alzheimer¿s disease". Paper presented in The International Congress on Neurodegenerative Diseases, 2023. Carnicero-Senabre, Daniel; Barata, Mariana Afonso; Guimas Almeida, Claudia; Rojo, Ana. "The Role of NRF2 I synaptic homeostasis". Paper presented in COST Action (Slovakia), 2023. Barata, Mariana Afonso; Perdigão, Catarina; Caulino-Rocha, Ana; Guimas Almeida, Claudia. "Late-onset Alzheimer¿s disease risk variants compromise Bin1 synaptic function". Paper presented in FENS Regional Meeting 2023 Algarve, 2023. Castanheira, Jorge; Mirfakhar, farzaneh; Domingues, Raquel; Almeida, Claudia G. "The impact of the actin-binding protein CD2AP and Alzheimer¿s risk factor on AMPAR trafficking". Paper presented in FENS Regional Meeting, 2023. Burrinha, Tatiana. "Lysosomal dysfunction contributes to age-dependent synapse loss". Paper presented in ADPD2023, 2023. Castanheira, Jorge; Domingues, Raquel; Mirfakhar, farzaneh; Almeida, Claudia G. "CD2AP, an Alzheimer¿s genetic risk factor, controls spinal F-actin and AMPAR trafficking in synapses". Paper presented in European Synapse Meeting (ESM), 2022. Raquel Domingues; Barata, Mariana Afonso; Castanheira, Jorge; Laura Quintas; Almeida, Claudia G. "Using Cell profiler for an unbiased and automatic analysis of sub synaptic alterations relevant for Alzheimer's disease". Paper presented in 8th European Synapse Meeting, 2022. Barata, Mariana Afonso; Perdigão, Catarina; Almeida, Claudia G. "Bin1 function in inhibitory synapses: compromised by Alzheimer¿s genetic risk variants". Paper presented in 8th European Synapse Meeting, 2022. Castanheira, Jorge; Mirfakhar, farzaneh; Almeida, Claudia G. "LOAD Genetic Risk Factor CD2AP impairs Glutamatergic Synapses". Paper presented in LYSOCIL Final Conference, 2022. Barata, Mariana; Perdigão, Catarina; Almeida, Claudia G. "Bin1 reduction affects synaptic vesicle cycle in inhibitory neurons". Paper presented in LYSOCIL Final Conference, 2022. Barata, Mariana Afonso; Perdigão, Catarina; Almeida, Claudia G. "Bin1 functions in inhibitory synapses: compromised by Alzheimer's genetic risk variants". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Barata, Mariana Afonso; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "Endosomal Trafficking Defects due to BIN1 Late-Onset Alzheimer's Disease Mutants Increase Intracellular Aß". Paper presented in Cell Bio Virtual 2021 (joint meeting of the ASCB and EMBO), 2021. Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosome dysfunction contribute to aging-dependent loss of synapses". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Barata, Mariana Afonso; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "Bin1 LOAD mutants increase intracellular Aß by interfering with BACE1 recycling". Paper presented in Alzheimer's Association International Conference 2021 (AAIC), 2021. Castanheira, Jorge; Mirfakhar, farzaneh; Almeida, Claudia G. Corresponding author: Almeida, Claudia G. "LOAD Gentic Risck Factor CD2AP impairs Glutamatergic Synapses". Paper presented in Vesicle Trafficking & Pathways to Neurodegeneration (Wellcome Connecting Science), 2021. Cunha, César; Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosomal subcellular mapping in cortical neurons: are there synaptic lysosomes?". Paper presented in Vesicle Trafficking & Pathways to Neurodegeneration, 2021. Cunha, César; Burrinha, Tatiana; Guimas Almeida, Claudia. "Maping lysosomal subcellular distribution in cortical neurons: are synaptic lysosomes a myth?". Paper presented in JCB-JEM 2021 Symposium on Neurodegeneration, 2021. Castanheira, Jorge; Mirfakhar, farzaneh; Guimas Almeida, Claudia. "Late-onset Alzheimer's disease genetic risk factor CD2AP functions at synapses". Paper presented in Vesicle Trafficking and Pathways to Neurodegeneration, 2021. Barata, Mariana; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "Understanding the impact of sporadic Alzheimer¿s disease mutations on BIN1". Paper presented in 11th AIMS Meeting, 2020. Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosome function with neuronal aging in vitro". Paper presented in LYSOCIL - Workshop on lysosome biology, 2019. Perdigão, Catarina; Barata, Mariana; Ana Marques; Burrinha, Tatiana; Almeida, Claudia G. "BIN1 variants increase beta-amyloid intracellular accumulation and affect synapses". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), 2019. Burrinha, Tatiana; Ricardo Gomes; Ana Paula Terrasso; Guimas Almeida, Claudia. "Lysosome (dys)function with neuronal aging". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences, 2019. Perdigão, Catarina; Brito, Catarina; Guimas Almeida, Claudia. "Towards a 3D model of late onset Alzheimer's Disease". Paper presented in Towards a 3D model of late onset Alzheimer's Disease, 2019. Burrinha, Tatiana; Ricardo Gomes; Figueira, Inês; Guimas Almeida, Claudia. "Cellular aging potentiates neuronal beta-amyloid production by increasing APP endocytosis". Paper presented in WORKSHOP ON INTEGRATIVE APPROACHES IN NEURODEGENERATION, 2018. Perdigão, Catarina; Burrinha, Tatiana; Barata, Mariana; Almeida, Claudia G. "BIN1 overexpression increases beta-amyloid intracellular accumulation". Paper presented in The 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2018. Burrinha, Tatiana; Ricardo Gomes; Ana Paula Terrasso; Guimas Almeida, Claudia. "Aged neurons endocytose more APP enhancing amyloid-dependent synapse loss". Paper presented in 1st Meeting on Vesicular Biology, 2018. Burrinha, Tatiana; Ricardo Gomes; Guimas Almeida, Claudia. "Why is aging the major risk factor for beta-amyloid accumulation and Alzheimer's disease development?". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, 2017. Burrinha, Tatiana; Ricardo Gomes; Guimas Almeida, Claudia. "How is aging altering APP trafficking, beta-amyloid accumulation and synaptic dysfunction?". Paper presented in Synaptic Function and Dysfunction in Brain Diseases, 7th ISN Special Neurochemistry Conference, 2016. Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Claudia. "Bin1 and CD2AP differentially regulate the endocytic generation of amyloid-beta". Paper presented in Super-resolution microscopy in infection and immunity symposium, 2015.
Journal article	Farzaneh S. Mirfakhar; Jorge Castanheira; Raquel Domingues; José S. Ramalho; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin". The Journal of Neuroscience (2024): https://doi.org/10.1523/JNEUROSCI.1734-23.2024. 10.1523/JNEUROSCI.1734-23.2024 Sabine C Konings; Emma Nyberg; Isak Martinsson; Laura Torres-Garcia; Oxana Klementieva; Guimas Almeida, Claudia; Gunnar K Gouras. "Apolipoprotein E intersects with amyloid-ß within neurons". Life Science Alliance (2023): https://doi.org/10.26508/lsa.202201887. 10.26508/lsa.202201887 Tatiana Burrinha; César Cunha; Michael J. Hall; Mafalda Lopes-da-Silva; Miguel C. Seabra; Cláudia Guimas Almeida. "Deacidification of endolysosomes by neuronal aging drives synapse loss". Traffic (2023): https://doi.org/10.1111/tra.12889. 10.1111/tra.12889 Domingues, N.; Marques, A.R.A.; Calado, R.D.A.; Ferreira, I.S.; Ramos, C.; Ramalho, J.; Soares, M.I.L.; et al. "Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages". Traffic 24 7 (2023): 284-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-85158007022&partnerID=MN8TOARS. 10.1111/tra.12888 Duarte C. Barral; Leopoldo Staiano; Cláudia Guimas Almeida; Dan F. Cutler; Emily R. Eden; Clare E. Futter; Antony Galione; et al. "Current methods to analyze lysosome morphology, positioning, motility and function". Traffic 23 5 (2022): 238-269. https://doi.org/10.1111/tra.12839. 10.1111/tra.12839 Tatiana Burrinha; Cláudia Guimas Almeida. "Aging impact on amyloid precursor protein neuronal trafficking". Current Opinion in Neurobiology 73 (2022): 102524-102524. https://doi.org/10.1016/j.conb.2022.102524. 10.1016/j.conb.2022.102524 Catarina Perdigão; Mariana A. Barata; Tatiana Burrinha; Cláudia Guimas Almeida. "Alzheimer's disease BIN1 coding variants increase intracellular Aß levels by interfering with BACE1 recycling". Journal of Biological Chemistry 297 3 (2021): 101056-101056. https://doi.org/10.1016/j.jbc.2021.101056. 10.1016/j.jbc.2021.101056 Claudia Guimas Almeida; Almeida, Claudia Guimas. "Synapses have autophagy under control". Journal of Cell Biology (2021): https://doi.org/10.1083/jcb.202105008. 10.1083/jcb.202105008 Tatiana Burrinha; Isak Martinsson; Ricardo Gomes; Ana Paula Terrasso; Gunnar K. Gouras; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss". Journal of Cell Science 134 9 (2021): https://doi.org/10.1242/jcs.255752. 10.1242/jcs.255752 Diógenes, M.J.; Guimas Almeida, C.; Xapelli, S.. "Editorial: Meeting of the Portuguese Society for Neurosciences SPN2019". Frontiers in Molecular Neuroscience 14 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117455505&partnerID=MN8TOARS. 10.3389/fnmol.2021.753500 Perdigão, Catarina; Barata, Mariana Afonso; Araújo, M.N.; Mirfakhar, farzaneh; Castanheira, Jorge; Guimas Almeida, Claudia. "Intracellular trafficking mechanisms of synaptic dysfunction in Alzheimer's disease". Frontiers in Cellular Neuroscience (2020): https://www.frontiersin.org/articles/10.3389/fncel.2020.00072/abstract. Open access • Accepted • 10.3389/fncel.2020.00072 Bettina Winckler; Victor Faundez; Sandra Maday; Qian Cai; Cláudia Guimas Almeida; Huaye Zhang; Winckler, Bettina; et al. "The Endolysosomal System and Proteostasis: From Development to Degeneration". The Journal of Neuroscience 38 44 (2018): 9364-9374. https://doi.org/10.1523/JNEUROSCI.1665-18.2018. 10.1523/JNEUROSCI.1665-18.2018 Cláudia Guimas Almeida; Farzaneh Sadat Mirfakhar; Catarina Perdigão; Tatiana Burrinha. "Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production". Cellular and Molecular Life Sciences 75 14 (2018): 2577-2589. https://doi.org/10.1007/s00018-018-2825-9. 10.1007/s00018-018-2825-9 Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Claudia. Corresponding author: Guimas Almeida, Claudia. "Measuring the Endocytic Recycling of Amyloid Precursor Protein (APP) in Neuro2a Cells". BIO-PROTOCOL 7 23 (2017): http://dx.doi.org/10.21769/bioprotoc.2635. Published Florent Ubelmann; Tatiana Burrinha; Laura Salavessa; Ricardo Gomes; Cláudio Ferreira; Nuno Moreno; Cláudia Guimas Almeida. "Bin1 and CD2AP polarise the endocytic generation of beta-amyloid". EMBO reports 18 1 (2017): 102-122. https://doi.org/10.15252/embr.201642738. 10.15252/embr.201642738 Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Cláudia. "A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution". BIO-PROTOCOL 7 23 (2017): http://dx.doi.org/10.21769/bioprotoc.2629. Open access • Published • 10.21769/bioprotoc.2629 Coudrier E; Almeida CG. "Myosin 1 controls membrane shape by coupling F-Actin to membrane.". BioArchitecture 1 5 (2011): 230-235. http://europepmc.org/abstract/med/22754614. Published • 10.4161/bioa.18406 Almeida, Claudia G.; Yamada, Ayako; Tenza, Danièle; Louvard, Daniel; Raposo, Graça; Coudrier, Evelyne. "Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network". Nature Cell Biology 13 7 (2011): 779-789. Published • 10.1038/ncb2262 Tampellini, D.; Magrane, J.; Takahashi, R. H.; Li, F.; Lin, M. T.; Almeida, C. G.; Gouras, G. K.. "Internalized Antibodies to the Abeta Domain of APP Reduce Neuronal Abeta and Protect against Synaptic Alterations". Journal of Biological Chemistry 282 26 (2007): 18895-18906. Published • 10.1074/jbc.M700373200 Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi; Almeida, Claudia G.; Greengard, Paul; Nyberg, Fred; et al. "The Arctic Alzheimer mutation favors intracellular amyloid-ß production by making amyloid precursor protein less available to a-secretase". Journal of Neurochemistry 101 3 (2007): 854-862. Published • 10.1111/j.1471-4159.2006.04443.x Almeida, C. G.; Takahashi, R. H.; Gouras, G. K.. "beta-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System". Journal of Neuroscience 26 16 (2006): 4277-4288. Published • 10.1523/JNEUROSCI.5078-05.2006 Almeida, Claudia G.; Tampellini, Davide; Takahashi, Reisuke H.; Greengard, Paul; Lin, Michael T.; Snyder, Eric M.; Gouras, Gunnar K.. "Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses". Neurobiology of Disease 20 2 (2005): 187-198. Published • 10.1016/j.nbd.2005.02.008 Snyder, Eric M; Nong, Yi; Almeida, Claudia G; Paul, Surojit; Moran, Timothy; Choi, Eun Young; Nairn, Angus C; et al. "Regulation of NMDA receptor trafficking by amyloid-ß". Nature Neuroscience 8 8 (2005): 1051-1058. Published • 10.1038/nn1503 Gouras, Gunnar K.; Almeida, Claudia G.; Takahashi, Reisuke H.. "Intraneuronal Aß accumulation and origin of plaques in Alzheimer's disease". Neurobiology of Aging 26 9 (2005): 1235-1244. Published • 10.1016/j.neurobiolaging.2005.05.022 Stenh, Charlotte; Englund, Hillevi; Lord, Anna; Johansson, Ann-Sofi; Almeida, Claudia G.; Gellerfors, Pär; Greengard, Paul; et al. "Amyloid-ß oligomers are inefficiently measured by enzyme-linked immunosorbent assay". Annals of Neurology 58 1 (2005): 147-150. Published • 10.1002/ana.20524 Li, Feng; Calingasan, Noel Y.; Yu, Fangmin; Mauck, William M.; Toidze, Marine; Almeida, Claudia G.; Takahashi, Reisuke H.; et al. "Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice". Journal of Neurochemistry 89 5 (2004): 1308-1312. Published • 10.1111/j.1471-4159.2004.02455.x Takahashi, R. H.; Almeida, C. G.; Patrick F. Kearney; Yu, Fangmin; Lin, Michael T.; Teresa A. Milner; Gouras, Gunnar K.. "Oligomerization of Alzheimer's -Amyloid within Processes and Synapses of Cultured Neurons and Brain". Journal of Neuroscience 24 14 (2004): 3592-3599. Published • 10.1523/JNEUROSCI.5167-03.2004 Gouras, G.; LaFerla, F.; Strobel, G.; Busciglio, J.; Almeida, C.; Geula, C.; Stenh, C.; et al. "Intraneuronal Aß accumulation-more evidence, less controversy? Alzheimer research forum live discussion". Journal of Alzheimer's Disease 6 4 (2004): 443-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-4644273867&partnerID=MN8TOARS. Almeida, Cláudia G.; de Mendonça, Alexandre; Cunha, Rodrigo A.; Ribeiro, J.Alexandre; Guimas Almeida, Claudia; Ribeiro, Joaquim A.. "Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices". Neuroscience Letters 339 2 (2003): 127-130. http://hdl.handle.net/10451/55413. Published • 10.1016/S0304-3940(02)01478-7 Whitaker, C.; Eckman, C.; Almeida, C.; Feinstein, D.; Atwood, C.; Eckman, E.; Crutcher, K.; et al. "Live discussion: Amyloid-ß degradation: The forgotten half of Alzheimer's disease". Journal of Alzheimer's Disease 5 6 (2003): 491-497. http://www.scopus.com/inward/record.url?eid=2-s2.0-9144274938&partnerID=MN8TOARS.
Preprint	Farzaneh S. Mirfakhar; Jorge Castanheira; Raquel Domingues; José S. Ramalho; Cláudia Guimas Almeida. "The Alzheimer’s disease risk gene CD2AP functions in dendritic spines by remodelling F-actin". 2023. https://doi.org/10.1101/2023.08.31.555707. 10.1101/2023.08.31.555707 Tatiana Burrinha; César Cunha; Cláudia Guimas Almeida. "Deacidification of distal lysosomes by neuronal aging drives synapse loss". 2022. https://doi.org/10.1101/2022.10.12.511921. 10.1101/2022.10.12.511921 Sabine C Konings; Emma Nyberg; Isak Martinsson; Laura Torres-Garcia; Claudia Guimas Almeida; Gunnar K Gouras. "Apolipoprotein E intersects with amyloid-ß within neurons". 2022. https://doi.org/10.1101/2022.12.13.520238. 10.1101/2022.12.13.520238 Catarina Perdigão; Mariana Barata; Tatiana Burrinha; Cláudia Guimas Almeida. "Alzheimer’s disease BIN1 coding variants increase intracellular Aß by interfering with BACE1 recycling". 2021. https://doi.org/10.1101/2021.06.09.447716. 10.1101/2021.06.09.447716 Domingues, N.; Calado, R.D.A.; Brito, P.H.; Matthiesen, R.; Ramalho, J.; Soares, M.I.L.; Pereira, T.; et al. "Cholesteryl hemiazelate induces lysosome dysfunction and exocytosis in macrophages". 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85101189621&partnerID=MN8TOARS. 10.1101/2021.01.05.422575 Tatiana Burrinha; Ricardo Gomes; Ana Paula Terrasso; Cláudia Guimas Almeida. "Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis". 2019. https://doi.org/10.1101/616540. 10.1101/616540
Thesis / Dissertation	"Investigating the Late-Alzheimer’s disease phenotype of CD2AP genetic risk in induced human neurons". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2024. http://hdl.handle.net/10400.5/97335. Burrinha, Tatiana. "Lysosome dysfunction, the link between aging and alzheimer’s disease?". PhD, 2023. http://hdl.handle.net/10362/148989. Mirfakhar, Farzaneh Sadat. "Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer's disease". PhD, 2023. http://hdl.handle.net/10362/156987. Piconêz, Tiago. "Uncovering the mechanism of CD2AP behind Alzheimer’s disease". Master, 2022. http://hdl.handle.net/10362/147637. "Perdigão, Catarina. The impact of the genetic risk factor BIN1 to Alzheimer¿s disease development". PhD, 2021. Araújo, Margarida Nóbrega Campos de Freitas. "Investigating the mechanisms of synaptic dysfunction in late-onset Alzheimer’s disease". Master, 2020. http://hdl.handle.net/10451/48747. Barata, Mariana Afonso. "Understanding the impact of sporadic Alzheimer’s disease mutations on BIN1". Master, 2019. http://hdl.handle.net/10362/86981. Bravo, Ana Francisca Rodrigues Vaz. "The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases". PhD, 2018. https://hdl.handle.net/1822/56267. Marques, Ana Cláudia Monteiro. "The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer’s Disease". Master, 2018. http://hdl.handle.net/10362/54375. "Oliveira, Luis. Quantitative nanoscopy of endosomal F-actin: Impact of an Alzheimer¿s risk factor". Master, 2018. "Posada, Adrian. In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy". PhD, Universidade Nova de Lisboa, 2018. https://run.unl.pt/handle/10362/57819?locale=en. Salavessa, Laura Nunes Soares Sequeira. "Endocytic trafficking mechanisms in Alzheimer's disease : role of the actin regulators bin l and CD2AP". Master, 2015. http://hdl.handle.net/10316/29641. Ferreira, Cláudio Miguel Letras da Silva, 1987-. "Identification of the cellular and molecular mechanism by which CD2AP, a regulator of neuronal intracellular transport contributes to the development of Alzheimer’s disease". Master, 2014. http://hdl.handle.net/10451/15737. Burrinha, Tatiana Marisa Andrade. "Bridging integrator 1 (BIN1) controls beta-amyloid accumulation in Alzheimer`s desease". Master, 2014. http://hdl.handle.net/10362/19898. Guimas Almeida, Claudia; Almeida, Cláudia Guimas de, 1976-; Almeida, Claudia G. "ß-amyloid-dependent neuronal dysfunction and effect on the endocytic pathway". PhD, 2007. http://hdl.handle.net/10451/6401.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/10/10	Endosomal trafficking defects in brain aging and Alzheimer’s disease	XXII SPB National Congress of Biochemistry, 2024 (Portugal)
2024/04/17	Endolysosomal system dysfunction in neurons during Aging and Alzheimer's disease	IB Conference 2024 Institute of Biomembranes, Utrecht University (Utrecht, Netherlands)
2024/03/20	Endolysosomal system dysfunction in neurons during Aging and Alzheimer's disease	Seminar Gotheburg University (Gotheburg, Sweden)
2024	CD2AP MAY CONTRIBUTE TO ALZHEIMER'S DISEASE SYNAPSE DYSFUNCTION BY DISRUPTING THE ACTIN CYTOSKELETON IN DENDRITIC SPINES	ADPD2024 (Lisboa, Portugal)
2023	The late-onset Alzheimer's disease risk factor CD2AP may impact synapses independently of beta-amyloid.	37ª Reunião anual do Grupo de Estudos de Envelhecimento cerebral e Demência Grupo de Estudos de Envelhecimento cerebral e Demência (Portugal)
2023	Imaging the Endolysosomal System Dysfunction in the normal aging brain: relevance for age-dependent synapse loss	FENS Regional Meeting: FRM 2023 FENS (Portugal)
2022	. Endosomal trafficking defects in aging and Alzheimer’s disease increase intracellular beta-amyloid	AD/PD 2022 ADPD (Spain)
2022	Neuronal trafficking defects during normal aging	Ageing Spring School 2022 MIA-Portugal (Portugal)
2022	Endosomal trafficking defects in aging and alzheimer’s disease increase intracellular beta-amyloid	AD/PD2022 ADPD (Spain)
2022	Investigating the causal mechanisms of late-onset Alzheimer's disease	ABC Days - V Encontro Anual do Algarve Biomedical Center Algarve Biomedical Center (Portugal)
2022	Neuronal trafficking defects during normal aging	Seminar King's College London (United Kingdom)
2022	Imaging Alzheimer’s Endosomal Defects at single synapses	Institute Seminar Marine biological Laboratory (WoodsHole, United States)
2021	Investigação básica em Neurociências	Curso de Introdução à Investigação Científica nowScience
2021	Alzheimer: What has already been discovered and what is yet to be discovered?	I SCORE Symposium AEFCM (Portugal)
2021	Impacto do Tráfego Intracelular no Alzheimer	Under A Biomedical Eye NEBM-IST (Portugal)
2021	Mechanisms of Neuronal Aging relevant for Alzheimer’s disease	Neuroscience seminar iMM (Portugal)
2021	Symposium talk: ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID	Portuguese Society for Neurosciences Bi-Annual meeting Portuguese Society for Neurosciences (Portugal)
2021	ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID	Seminar Achucarro Neuroscience center (Spain)
2021	ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID	SynAge Seminar Institute of Biology, Department for Molecular Neurobiology and Genetics (Germany)
2019	Impact of late-onset Alzheimer’s disease risk factors on synapses	Synaptic Function, Dysfunction and Repair Workshop UCL & The Discoveries Centre for Regenerative and Precision Medicine (Lisboa, Portugal)
2019	Impact of late-onset Alzheimer’s disease risk factors on synapses	Seminar U Catolica (Santiago, Chile)
2019	Actin control of neuronal endosomal sorting: implications for Alzheimer's disease	EMBO Workshop "Neuronal Cytoskeleton" EMBO (Chile)
2019	Endosomal trafficking defects in aging and Alzheimer’s Disease	ADPD 2019 https://adpd.kenes.com/2019 (Lisboa, Portugal)
2018	Endosomal trafficking defects and Alzheimer’s Disease	Mini-Symposium "Membrane Trafficking: from development to degeneration" SFN 2018, Nov 2018, San Diego SFN 2018 (United States)
2018	Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease	Seminar Achucarro Basque Center for Neurosciences (bilbao, Spain)
2018	Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease	Seminar Centre de Psychiatries et Neurosciences (Paris, France)
2018	Endosomal trafficking defects in aging and Alzheimer's disease	Biochemistry department seminar U Toronto (Toronto, Canada)
2018	Actin control of endosomal sorting in neurons: implications for Alzheimer's disease	9th Meeting Signal Transduction (Lisbon, Portugal)
2018	Cellular Aging impairs synapses via beta-amyloid accumulation and APP endocytosis	Society for Neuroscience 2018 (San Diego, United States)
2017	Proteostasis in Alzheimer’s disease	EMBO Workshop "Proteostasis" EMBO (Ericeira, Portugal)
2017	The Alzheimer's risk factors Bin1 and CD2AP polarize the endocytic generation of ß-amyloid	EMBO Conference on Molecular Mechanisms of Neurodegeneration (Heidelberg, Germany)
2017	Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease	World Alzheimer Global Summit (Lisbon, Portugal)
2015	The Alzheimer’s risk factors BIN1 and CD2AP differentially control the endocytic generation of ß-amyloid	Seminar CIMR (Cambridge, United Kingdom)
2015	Investigating the contribution of endocytic trafficking defects to Alzheimer’s disease development	CNC seminar Seminar (Coimbra, Portugal)
2015	Investigating the contribution of endocytic trafficking defects to Alzheimer´s disease development	“Pathogenesis of Neurodegenerative Disorders – found a common ground” course 20-24 April 2015 ICVS (Braga)
2015	The Alzheimer's risk factors Bin1 and CD2AP differentially regulate the endocytic generation of amyloid-ß	Society for Neuroscience 2015 (Chicago, United States)
2014	How are regulators of intracellular trafficking risk-factors for Alzheimer´s disease?	iMM Monday lectures iMM (Lisbon, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020 - Current	Breaking BIN1: Investigating mechanisms of synaptic dysfunction in Alzheimer’s disease Supervisor	Ciências da Saúde (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - Current	Association of the Endocytic Trafficking Regulator CD2AP Gene Variant K633R And the Risk of Developing Alzheimer’s Disease. Supervisor
2017 - Current	Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer’s disease Supervisor	Mecanismos de Doença e Medicina Regenerativa (associação) (PhD) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2018/10 - 2022/06	Lysosomes dysfunction, the link between Aging and Alzheimer´s disease? Supervisor
2020 - 2022	Investigating mechanisms of lysosome dysfunction with aging Supervisor of César Cunha
2018 - 2022	Lysosomes dysfunction, the link between Aging and Alzheimer´s disease? Supervisor	Biomedicina (associação) (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2021/12	The impact of the genetic risk factor BIN1 to Alzheimer's disease development Supervisor	Ph.D. program in Bioengineering – Cell Therapies and Regenerative Medicine (PhD)
2019 - 2021	Investigating the mechanisms of synaptic dysfunction in late-onset Alzheimer's disease Supervisor of Margarida Araújo	Molecular Biology and Genetics (Master)
2017 - 2021	The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases Co-supervisor	Envelhecimento e Doenças Crónicas (associação) (PhD) Universidade do Minho, Portugal
2018 - 2019	Understanding the impact of sporadic Alzheimer’s disease mutations on BIN1 Supervisor
2016 - 2019	HEART ISCHEMIA GIVES A SECOND LIFE TO CX43 NOVEL ROLES ASCRIBED TO CX43 THAT GO BEYOND GAP JUNCTION INTERCELLULAR COMMUNICATION Co-supervisor
2017 - 2018	The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer's Disease Supervisor
2014 - 2018	In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy Co-supervisor
2014 - 2018	Neural cell models for disease modeling and drug discovery Exploiting 3D differentiation of human stem cells Co-supervisor
2014 - 2018	The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases Co-supervisor
2015 - 2015	Endocytic trafficking mechanisms in Alzheimer´s disease: role of the actin regulators bin l and CD2AP Supervisor	Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015	Endocytic trafficking mechanisms in Alzheimer’s disease: role of the actin regulators Bin1 and CD2AP Supervisor
2013 - 2014	Bridging Integrator 1 (BIN1) controls beta-amyloid accumulation in Alzheimer's disease Supervisor
2013 - 2014	Identification of the cellular and molecular mechanism by which CD2AP, a regulator of neuronal intracellular transport contributes to the development of Alzheimer's disease. Supervisor

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023 - Current	Representing non-tenure NMS Researchers (2023)	Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023 - Current	ADPD 2024 - Advisory Board (2024/03) Congress (Member of the Scientific Committee)
2021 - Current	Lysocil Summer School: Lysosome and Cilia interactions (2021 - 2021) Workshop (Co-organisor)	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019 - Current	Lysosome Workshop - within the activities of the Twinning project LYSOCIL (2019) Workshop (Co-organisor)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2020	The organizer of CEDOC's Casual Friday seminars (2018) Seminar	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019 - 2019	Co-organizer of the 2019 Meeting of the Portuguese Society for Neurosciences (2019 - 2019) Congress (Co-organisor)	Sociedade Portuguesa de Neurociências, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2022 - Current	PintofScience Portugal, O Que causa a doença de Alzheimer?, Cabecinha Pensadora Meeting	Cabecinha Pensadora
2020 - Current	Araújo, M.N., Mirfakhar, F.S., Almeida, C.G. “Impact of a late-onset Alzheimer’s disease CD2AP mutation on intracellular amyloid-beta production”. AstraZeneca Foundation Innovate Competition Congress	iMed Conference 12.0 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current	Perdiga~o, Catarina; Brito, Catarina; Almeida, Claudia G. "Towards a 3D model of late-onset Alzheimer's Disease". Poster presented in NOVA Science Day, 2019. Congress	NOVA Science Day

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023	Axonal transport (Thesis) Main arguer	João Machado (Master) Universidade de Coimbra, Portugal
2023	Proteostasis and exosomes Thesis Member	Catarina Meyer (PhD) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023	Alzheimer's disease human adult cellular models (Thesis) Main arguer	Katrine Hanssen (PhD) Norges teknisk-naturvitenskapelige universitet, Norway
2021	CHARACTERIZATION OF THE RHO GTPASE ACTIVATING PROTEIN, ARHGAP8, IN THE CENTRAL NERVOUS SYSTEM (Thesis) Main arguer	Jeannette Schmidt (PhD) Universidade de Coimbra, Portugal
2019	Regulation of cellular signalling by trafficking control (Thesis) Arguer	Ioanna Oikonomidi (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Instituto Gulbenkian de Ciência, Portugal
2019	UNRAVELING THE MECHANISMS OF NEURONAL DEVELOPMENT IN THE HIPPOCAMPUS (Thesis) Main arguer	Susana Sampaio (PhD) Universidade de Coimbra, Portugal
2019	Klotho: relevance in the control of neuroinflammation in Parkinson’s disease (Thesis) Main arguer	Rui Jorge Januário Gaspar (Master) Universidade da Beira Interior, Portugal
2018	UNVEILING THE ROLE OF MIRNAS IN SYNAPTIC PLASTICITY (Thesis) Main arguer	Mariline Mendes Silva (PhD)
2017	Characterizing Alzheimer’s Amyloid Precursor Protein (APP) neurotrophic functions (Thesis) Main arguer	Joana Rocha (PhD) Universidade de Aveiro, Portugal
2016	Dissecting the role of the Ral/Exocyst pathway in postsynaptic growth and activity-dependent plasticity (Thesis) Arguer	Cátia Filipa Patrício Rodrigues (Master) Universidade Nova de Lisboa, Portugal
2015	Novel in vitro human 3D neural model derived from induced pluripotent stem cells (Thesis) Main arguer	Francisca Maria de Andrade Terras Arez (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014	The role of the endocytic and autophagic molecular machineries in the removal of apoptotic cells (Thesis) Main arguer	Michelle Viegas (PhD) Universidade de Coimbra, Portugal
2014	Exploring deregulated signals involved in Motor neuron-Microglia cross-talk in ALS (Thesis) Main arguer	Maria Inês Fazendeiro Cunha (Master) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2023 - Current	Journal of Cell science
2023 - Current	Brain Aging
2023 - Current	Alzheimer's and Dementia
2022 - Current	Journal Cellular Phisiology
2022 - Current	Science Advances
2022 - Current	Pharmacological Research
2022 - Current	Neurotoxicity Research
2022 - Current	Autophagy
2021 - Current	Cells
2020 - Current	Acta Neuropathologica Communications
2020 - Current	Molecular Neurobiology
2020 - Current	Plos Neglected Diseases
2020 - Current	Scientific Reports
2019 - Current	Cellular and Molecular Life Sciences (1420-9071)	Springer-Verlag
2019 - Current	Cytoskeleton (1949-3592)	Wiley (John Wiley & Sons)
2019 - Current	EMBO Reports (1469-3178)	EMBO
2019 - Current	FEBS Letters (1873-3468)	Wiley (John Wiley & Sons)
2018 - Current	Neurobiology of Aging (0197-4580)	Elsevier
2018 - Current	Neurochemical Research (1573-6903)	Springer-Verlag
2018 - Current	PLoS ONE (1932-6203)	Public Library of Science
2017 - Current	Frontiers in Molecular Neuroscience (1662-5099)	Frontiers Media SA
2017 - Current	Journal of Alzheimer s Disease (1875-8908)	IOS Press
2017 - Current	Molecular and Cellular Neuroscience (1095-9327)	Elsevier

Association member

	Society Organization name	Role
2021 - Current	COST ACTION: CA20121 - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases	member of WG1 - Tools for NRF2 research.
2015 - Current	International Society for Neurochemistry
2009 - Current	SPN - Portuguese Society of Neurosciences
2007 - Current	Club exo-endocytosis
2004 - Current	American Society for Cell Biology
2003 - Current	Society for Neurosciences
2002 - Current	Alzforum.org
2000 - Current	ANBIOQ
1998 - Current	Sociedade Portuguesa de Bioquímica

Committee member

	Activity description Role	Institution / Organization
2024 - Current	Biomedicine FCT panel for PhD fellowships Member
2023 - Current	NMS Research Committee Member	Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022 - Current	Recruitment Juri: Technician in Bioimaging, Member	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - Current	Recruitment Juri: International recruitment of Assistant Researcher in Neurosciences Member	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Current	Recruitment Juri: International recruitment of Junior Researcher in Neurosciences, i3S, Porto Member	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021 - Current	Scientific Council - representative of iNOVA4Health researchers Member	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - Current	Scientific Council member Member	Universidade NOVA de Lisboa NOVA Medical School, Portugal

Conference scientific committee

	Conference name	Conference host
2024 - Current	ADPD2024	ADPD
2023 - Current	PIATI conference	NOVA Medical School, Lisbon
2015 - 2019	iMED	NOVA Medical School

Consulting

	Activity description	Institution / Organization
2013 - Current	Scientific coordinator of CEDOC's Imaging platform	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2013 - 2023	Scientific coordinator of CEDOC's Imaging platform	Universidade NOVA de Lisboa NOVA Medical School, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020 - Current	Lectures, Tutor; PhD program Health Sciences	(Doutoramento)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - Current	Critical Skills in Research - NBR course		Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2033	co-organized RARE DISEASES AND NEURODEGENERATION ADVANCED COURSE – PhD program Health Sciences	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal EIT Health, Germany
2022 - 2033	co-organized Molecular and Cellular Mechanisms of Aging ADVANCED COURSE – PhD program Health Sciences, NMS.	AGING (Doutoramento)
2021 - 2022	Research Project Course – MIM – Integrated Master in Medicine		Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018	seminar and tutor; Neurodegenerative disease; Molecular Mechanisms of Disease – MIM – Integrated Master in Medicine
2016 - 2018	Research Seminars course director - NBR Master	(Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2016	Contributed lectures – Neuroscience course, BSc Life Sciences	Neurosciences	Universidade do Algarve - Campus de Gambelas, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2024 - Current	Panel committee Neurodegenerative diseases Call 2024	Fondation pour la Recherche Médicale, France
2023 - Current	External Reviewer Evaluator	Agence nationale de la recherche, France	Agence nationale de la recherche
2020 - Current	Panel committee Evaluator	Alzheimer's Association, United States	Alzheimer's Association
2020 - Current	External reviewer Evaluator	Alzheimer Research Foundation, Belgium	Alzheimer Research Foundation
2020 - Current	External Reviewer Evaluator	Alzheimer Research UK, United Kingdom	Alzheimer Research UK
2019 - Current	External reviewer Evaluator	The Czech Science Foundation (GACR), Czech Republic	The Czech Science Foundation (GACR)
2018 - Current	External Reviewer	Alzheimer Research Foundation, Belgium	Alzheimer Research Foundation
2018 - Current	External Reviewer Evaluator	Association France Alzheimer et Maladies Apparentées, France	Association France Alzheimer et Maladies Apparentées
2018 - Current	External Reviewer Evaluator	Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium	Fonds Wetenschappelijk Onderzoek Vlaanderen
2017 - Current	Reviewer - PePita Evaluator	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
2017 - Current	Pfizer award reviewer		Pfizer Portugal
2017 - Current	Selection Committee of master students for the NOVA Biomedical Research master - NBR Evaluator	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - Current	External reviewer Evaluator	Alzheimer's Association, United States	Alzheimer's Association

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2021	“Dados fracos, custos elevados. A polémica aprovação do medicamento para o Alzheimer”	Observador
2021	Equipa portuguesa faz descoberta que pode travar a doença de Alzheimer, Uma equipa de investigadores portugueses identificou um novo mecanismo associado aos neurónios envelhecidos	Zap Notícias
2021	https://www.publico.pt/2021/06/19/ciencia/noticia/alzheimer-ha-nova-pista-neuronios-velhos-perdem-sinapses-1966895	Publico

Interview (tv / radio show)

	Program	Topic
2023 - Current	RTP1 documentary "100 ou +" by Farol de ideias	Aging
2023 - Current	90 segundos de ciência - RTP podcast - Ep.30	Science

Mentoring / Tutoring

	Topic	Student name
2025 - Current	Thesis committee	Ana Rita Ferreira Fernandes

Distinctions

Award

2024	Alzheimer's Association conference fellowship Alzheimer's Association, United States
2022	1st Edition \| International Blended Learning Award 2022- Health and Wellbeing is Critical Skills in Research, with P. Pereira and R. Teodoro, Universidade Nova de Lisboa, Portugal
2018	FLAD Travel Grant Fundação Luso-Americana, Portugal
2018	SPN Travel Grant Sociedade Portuguesa de Neurociências, Portugal
2017	Award Maratona da Saúde Neurodegenerative Diseases 2016 Maratona da Saúde/Biogen, Portugal
2016	Honorable mention, Award Criostaminal 2016 Criostaminal, Portugal
2015	Award Santander/Totta and Universidade NOVA de Lisboa, 2015 Banco Santander Totta, Portugal Universidade Nova de Lisboa, Portugal
2010	WICB Childcare Grant for ASCB 2010 American Society of Cell biology, United States
2004	Travel Fellowship for the 9th International Conference on Alzheimer's Disease and Related Disorders

Other distinction

2017	CEEC Individual Fundação para a Ciência e a Tecnologia, Portugal
2013	Investigator FCT Fundação para a Ciência e a Tecnologia, Portugal
2011	Curie International Post-doc Fellowship Institut Curie, France
2009	Marie Curie post-doctoral fellowship Marie Curie Actions, Portugal
2007	EMBO long-term fellowship EMBO, Portugal
2002	PhD fellowship Fundação para a Ciência e a Tecnologia, Portugal
2001	Master Fellowship Fundação para a Ciência e a Tecnologia, Portugal