???global.info.a_carregar???
Cláudia Guimas Almeida is a Principal Investigator at NOVA Medical School (Universidade NOVA de Lisboa, Lisbon), where she leads the Neuroscience of Aging and Alzheimer laboratory. Her research dissects how endolysosomal and endocytic trafficking failures trigger early synaptic dysfunction in brain aging and Alzheimer’s disease (AD), with particular focus on late-onset genetic risk factors BIN1 and CD2AP and their impact on receptor trafficking, vesicle cycling, and actin-dependent synaptic remodelling. She trained in biochemistry (BSc, 1999) and neuroscience (MSc, 2002; PhD, 2007, University of Lisbon). Her PhD research was conducted at Weill Cornell Medical College in the laboratory of Gunnar Gouras, contributing to evidence that intraneuronal ß-amyloid accumulation perturbs endosomal/MVB pathways and compromises synaptic receptor integrity. She then pursued cell-biology training at Institut Curie (Paris) as an EMBO and Marie Curie postdoctoral fellow, contributing to work showing how the unconventional motor myosin1b regulates actin assembly and membrane remodelling at the trans-Golgi network to support post-Golgi carrier formation. Since founding her independent group in 2013, supported by FCT (including Investigator FCT and CEEC), her team has built human neuron-based and quantitative imaging pipelines to link trafficking defects to synaptic vulnerability and to nominate mechanism-based rescue strategies. She has authored ~30 publications (~5850 citations) and secured >€1.1M in competitive project funding (˜€1.88M including contracts), spanning FCT, Horizon Europe Twinning, Marie Curie, and the Alzheimer’s Association.
Read full resume ↓
Identification

Personal identification

Full name
Cláudia Guimas de Almeida Gomes

Citation names

  • Guimas Almeida, Claudia
  • Almeida, Claudia G.

Author identifiers

Ciência ID
CA10-FD1E-99FD
ORCID iD
0000-0001-9384-2896
Google Scholar ID
https://scholar.google.com/citations?user=7sb3PWYAAAAJ&hl=en
Scopus Author Id
57303082300

Addresses

  • NOVA Medical School - Universidade NOVA de Lisboa. Campo Mártires da Pátria, 130, 1169-056 , Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
French Elementary (A2) Upper intermediate (B2) Intermediate (B1) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2007 - 2012
Concluded
 Post-doc in Cell Biology (Pós-doutoramento)
Institut Curie, France
2002 - 2007
Concluded
 Biomedical Sciences- Basic Neurosciences (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal

Weill Medical College of Cornell University, United States
"beta-amyloid-dependent neuronal dysfunction and effect on the endocytic pathway" (THESIS/DISSERTATION)
1999 - 2002
Concluded
 Neurosciences (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Adenosine promotes the neuronal recovery from the reactive oxygen species induced lesion" (THESIS/DISSERTATION)
1994 - 1999
Concluded
 Biochemistry (Licenciatura)
Faculdade de Cências da Universidade de Lisboa, Portugal
"Alterations in bile acids and bilirubin levels in hepatic disease and studies on bilirubin-induced phosphatidylserine externalization in the membrane of human erythrocytes" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2013/04/01 - Current Principal Investigator (Research) Universidade Nova de Lisboa, Portugal
Universidade NOVA de Lisboa NOVA Medical School, Portugal
(...)
2018 - 2022 Invited Auxiliary Researcher (Research) Marine Biological Laboratory, United States
Marine Biological Laboratory, United States
2007/03 - 2012/02 Researcher (Research) Institut Curie, France
2002/03 - 2007/02 Researcher (Research) Weill Medical College of Cornell University, United States

Teaching in Higher Education

Category
Host institution 		Employer
2018 - 2019 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
2016 - 2018 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
Projects

Grant

Designation Funders
2026/02/02 - Current FCT PEX2025: Synapse Protection: A Novel Therapeutic Strategy for Alzheimer's Disease
2024.15725.PEX
10.54499/2024.15725.PEX
Principal investigator
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/11 - Current CaixaResearch: Early detection of neurodegenerative diseases through the study of tau protein aggregates
LCF/PR/HR24/52440012
Researcher
Universidade Nova de Lisboa, Portugal
 Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa'
Ongoing
2024 - Current Horizon Europe: Twinning MPS_NOVA European Hub of Excellence in Microphysiological Systems (MPS) (GA 101159729).
HORIZON-WIDERA-2023-ACCESS-02-01
Researcher
Horizon 2020
Ongoing
2023/09/01 - Current FCT LA LS4Future: Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Researcher
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

GREEN-IT, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - Current Horizon Europe Twinning: Centre for Excellence in Diagnostic and Advanced Therapeutics based on Extracellular Vesicles (EVCA)
Horizon GA nº 101079264
Researcher
Universidade NOVA de Lisboa NOVA Medical School, Portugal
 Horizon 2020
Ongoing
2017 - Current FCT UID: iNOVA4Health - Programa de Medicina Translacional iBET, NMS, IPOLFG, ITQB e NIMSB
UID/Multi/04462/2019
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2024 Alzheimer's Association rapid funding (USA): Understanding the impact of a late-onset AD mutation in CD2AP on synapses
AARG-19-618007-RAPID
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Alzheimer's Association
Concluded
2019/01 - 2024 Alzheimer's Association research grant (USA): Understanding the impact of a late-onset AD mutation in CD2AP on synapses
2168
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Alzheimer's Association
Concluded
2018/10/01 - 2022/06/30 FCT project: Lysosome dysfunction in age-related diseases
PTDC/MED-PAT/30385/2017
Researcher
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022/04 H2020 Twinning: Excel in Rare Diseases Research: Focus on Lysosomal Disorders and Ciliopathies (LYOSOCIL)
H2020-TWINN-2017-811087
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
Concluded
2016/06 - 2020/05 JPND/H2020: Development of a Novel Multicellular In Vitro Model of Alzheimer's disease-like Blood-Brain Barrier
JPCOFUND/0004/2015 - NAB3
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2019 FCT UID INOVA4Health Seed project: Do genetic variants in CD2AP increase the risk of developing Alzheimer's disease?
iNOVA4Health/2017/40
Principal investigator
Universidade NOVA de Lisboa NOVA Medical School, Portugal
 iNOVA4Health
Concluded
2013/04 - 2017/03 Marie Curie Integration grant: Traffic in AD
334366
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 European Commission
Concluded

Contract

Designation Funders
2022/12/15 - Current Principal Investigator R&D FCT iNOVA4Health
UID/Multi/04462/2019
Principal investigator
iNOVA4Health, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/03/01 - 2022/10/17 CEECind 2017: Assistant Investigator Contract (Cancelled in 2022)
CEECIND/00410/2017/CP1421/CT0001
10.54499/CEECIND/00410/2017/CP1421/CT0001
Principal investigator
Universidade Nova de Lisboa Medical School, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/05/15 - 2018/05/14 Investigator FCT (Starting iFCT)
IF/00998/2012/CP0182/CT0004
Provided by PTCRIS: 147476
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Medical School, Portugal
Fundação para a Ciência e a Tecnologia

Secretaria de Estado de Ciência Tecnologia e Ensino Superior
Concluded
Outputs

Publications

Book chapter
  1. "Age-related diseases: common mechanisms and therapeutic approaches". In In "Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata, 246-259. Universidade Nova de Lisboa and Fundação Amélia de Mello, 2021.
    Published
Conference abstract
  1. Claudia G Almeida; Mariana Afonso Barata; Catarina Perdigão; Jose Ramalho. Corresponding author: Claudia G Almeida. "Basic Science and Pathogenesis". 2024.
    10.1002/alz.087074
  2. Guimas Almeida, Claudia; Barata, Mariana; Perdigão, Catarina; Ramalho, Jose. "Bin1 regulates synaptic endocytic trafficking compromised by Alzheimer’s genetic risk variants". Paper presented in Alzheimer's & Dementia: Alzheimer's Association International Conference 2024 (AAIC), Philadelphia, 2024.
  3. Guimas Almeida, Claudia; Burrinha, Tatiana. "Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis.". Paper presented in FENS Virtual Forum, 2021.
  4. Mirfakhar, farzaneh; Guimas Almeida, Claudia. "Alzheimer's disease risk factor CD2AP functions at synapses via spinal F-actin". Paper presented in 2021 Alzheimer's Association International Conference, 2021.
    Published • https://doi.org/10.1002/alz.043900
  5. "Lysosomal subcellular distribution in neurons: are there synaptic lysosomes?". Paper presented in 2021 Alzheimer's Association International Conference, 2021.
  6. Burrinha, Tatiana. "Upregulation of APP Endocytosis by Neuronal Aging Drives Amyloid-Dependent Synapse Loss". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021.
    10.1242/jcs.255752
  7. Araújo, Margarida. "Actin Controls APP Endosomal Sorting: Implications for Alzheimer's Disease". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021.
  8. Cunha, César; Burrinha, Tatiana. "Disclosing lysosomal dysfunction in cortical neuronal aging: a promising driver of early synaptic degeneration in Alzheimer’s Disease". Paper presented in Cell Bio Virtual 2021 MBoC abstracts, 2021.
  9. Guimas Almeida, Claudia; Perdigão, Catarina; Barata, Mariana Afonso. "Alzheimer's disease variants in the genetic risk factor BIN1 increase Beta-Amyloid accumulation by decreasing Bace1 recycling". Paper presented in FENS Virtual Forum 2020, 2020.
  10. Mirfakhar, farzaneh; Guimas Almeida, Claudia. Corresponding author: Guimas Almeida, Claudia. "The late-onset Alzheimer's disease genetic risk factor CD2AP impacts synapses via actin dynamics: Basic science and pathogenesis: Genetics and omics of AD". Paper presented in 2020 Alzheimer's Association International Conference - Journal Alzheimer's & Dementia, 2020.
    https://doi.org/10.1002/alz.043900
  11. Figueira, Inês; Salavessa, Laura; Oliveira, Luís; Guimas Almeida, Claudia. "Actin as a key player in the control of neuronal endosomal sorting: implications for Alzheimer's disease". Paper presented in ADPD2019, Lisboa, 2019.
    Published
  12. Almeida, Claudia G; T Martins-marques; S Catarino; C G Almeida; H Girao. "P2286 EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia". Paper presented in European Heart Meeting, 2018.
    10.1093/eurheartj/ehy565.P2286
  13. Almeida, Claudia G. "P4-260: Intraneuronal Aß42 and microtubule-associated protein pathologies begin in synapses". Paper presented in AAIC, 2008.
  14. Zhang, Q; Gerratana, L; Zhang, Y; Flaum, L; Shah, A; Davis, A; Behdad, A; et al. "P4-041: The Arctic Alzheimer mutation favors Aß production by making APP less available to a-secretase at the cell surface". Paper presented in Alzheimer Association International meeting, 2006.
    10.1158/1538-7445.sabcs18-p4-01-04
  15. Almeida, Claudia G. "P4-050: Endogenous Abeta42 accumulation in neurons impairs the multivesicular body sorting pathway". Paper presented in Alzheimer 's Association International meeting, 2006.
  16. Almeida, Claudia G. "O4-06-08: Internalized antibodies to the Aß domain of APP reduce intraneuronal Aß and protect against synaptic alterations". Paper presented in AAIC, 2006.
  17. Almeida, Claudia G; Davide Tampellini; Claudia G. Almeida; Eric M. Snyder; Reisuke H. Takahashi; Giovanni Manfredi; Gunnar K. Gouras. "P3-322 Altered expression of synaptic and immediate early genes in a neuronal culture model of Alzheimer's disease". 2004.
    10.1016/S0197-4580(04)81472-6
  18. Almeida, Claudia G. "P3-313 Significance of intraneuronal Aß accumulation in Alzheimer's disease". 2004.
  19. Almeida, Claudia G. "O4-02-04 The arctic APP mutation affects Aß production and its site of cellular aggregation in Alzheimer's disease". 2004.
    Published
  20. Almeida, Claudia G. "P3-314 Aß42 accumulation in endosomes is associated with synaptic alterations". 2004.
  21. Almeida, Claudia G. "P1-195 Oligomerization of Alzheimer's Aß within processes and synapses of cultured neurons and brain". 2004.
  22. Almeida, Claudia G. "Beta-amyloid accumulation in late endosomes/MVBs in cultured neurons is associated with alterations in endocytosis". Paper presented in ASCB, 2004.
Conference poster
  1. Barata, Mariana Afonso; Caulino-Rocha, Ana; Ana Carvalho; Ramalho, Jose; Matthiesen, Rune; Hans C. Beck ; Edgar R. Gomes; Milosevic, Ira; Guimas Almeida, Claudia. "Mapping BIN1 interactome in Late-Onset Alzheimer’s Disease: Disruptions in synaptic vesicle cycling and inhibitory synapse integrity". 2025.
  2. Carnicero-Senabre, Daniel; Barata, Mariana Afonso; Guimas Almeida, Claudia; Rojo, Ana. "Defining the role of the NRF2 transcription factor in synaptic maintenance in Alzheimer¿s disease". Paper presented in The International Congress on Neurodegenerative Diseases, 2023.
  3. Carnicero-Senabre, Daniel; Barata, Mariana Afonso; Guimas Almeida, Claudia; Rojo, Ana. "The Role of NRF2 I synaptic homeostasis". Paper presented in COST Action (Slovakia), 2023.
  4. Barata, Mariana Afonso; Perdigão, Catarina; Caulino-Rocha, Ana; Guimas Almeida, Claudia. "Late-onset Alzheimer¿s disease risk variants compromise Bin1 synaptic function". Paper presented in FENS Regional Meeting 2023 Algarve, 2023.
  5. Castanheira, Jorge; Mirfakhar, farzaneh; Domingues, Raquel; Almeida, Claudia G. "The impact of the actin-binding protein CD2AP and Alzheimer¿s risk factor on AMPAR trafficking". Paper presented in FENS Regional Meeting, 2023.
  6. Burrinha, Tatiana. "Lysosomal dysfunction contributes to age-dependent synapse loss". Paper presented in ADPD2023, 2023.
  7. Castanheira, Jorge; Domingues, Raquel; Mirfakhar, farzaneh; Almeida, Claudia G. "CD2AP, an Alzheimer¿s genetic risk factor, controls spinal F-actin and AMPAR trafficking in synapses". Paper presented in European Synapse Meeting (ESM), 2022.
  8. Raquel Domingues; Barata, Mariana Afonso; Castanheira, Jorge; Laura Quintas; Almeida, Claudia G. "Using Cell profiler for an unbiased and automatic analysis of sub synaptic alterations relevant for Alzheimer's disease". Paper presented in 8th European Synapse Meeting, 2022.
  9. Barata, Mariana Afonso; Perdigão, Catarina; Almeida, Claudia G. "Bin1 function in inhibitory synapses: compromised by Alzheimer¿s genetic risk variants". Paper presented in 8th European Synapse Meeting, 2022.
  10. Castanheira, Jorge; Mirfakhar, farzaneh; Almeida, Claudia G. "LOAD Genetic Risk Factor CD2AP impairs Glutamatergic Synapses". Paper presented in LYSOCIL Final Conference, 2022.
  11. Barata, Mariana; Perdigão, Catarina; Almeida, Claudia G. "Bin1 reduction affects synaptic vesicle cycle in inhibitory neurons". Paper presented in LYSOCIL Final Conference, 2022.
  12. César Augusto Vogado Cunha; Tatiana Burrinha; Claudia G. Almeida. "Lysosomal subcellular distribution in neurons". 2022.
    10.1002/alz.053844
  13. Barata, Mariana Afonso; Perdigão, Catarina; Almeida, Claudia G. "Bin1 functions in inhibitory synapses: compromised by Alzheimer's genetic risk variants". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  14. Barata, Mariana Afonso; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "Endosomal Trafficking Defects due to BIN1 Late-Onset Alzheimer's Disease Mutants Increase Intracellular Aß". Paper presented in Cell Bio Virtual 2021 (joint meeting of the ASCB and EMBO), 2021.
  15. Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosome dysfunction contribute to aging-dependent loss of synapses". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  16. Castanheira, Jorge; Mirfakhar, farzaneh; Almeida, Claudia G. Corresponding author: Almeida, Claudia G. "LOAD Gentic Risck Factor CD2AP impairs Glutamatergic Synapses". Paper presented in Vesicle Trafficking & Pathways to Neurodegeneration (Wellcome Connecting Science), 2021.
  17. Cunha, César; Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosomal subcellular mapping in cortical neurons: are there synaptic lysosomes?". Paper presented in Vesicle Trafficking & Pathways to Neurodegeneration, 2021.
  18. Cunha, César; Burrinha, Tatiana; Guimas Almeida, Claudia. "Maping lysosomal subcellular distribution in cortical neurons: are synaptic lysosomes a myth?". Paper presented in JCB-JEM 2021 Symposium on Neurodegeneration, 2021.
  19. Castanheira, Jorge; Mirfakhar, farzaneh; Guimas Almeida, Claudia. "Late-onset Alzheimer's disease genetic risk factor CD2AP functions at synapses". Paper presented in Vesicle Trafficking and Pathways to Neurodegeneration, 2021.
  20. Farzaneh S. Mirfakhar; Claudia G. Almeida. Corresponding author: Claudia G. Almeida. "Alzheimer's disease risk factor CD2AP functions at synapses via spinal F-actin". 2021.
    10.1002/alz.053797
  21. Barata, Mariana; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "Understanding the impact of sporadic Alzheimer¿s disease mutations on BIN1". Paper presented in 11th AIMS Meeting, 2020.
  22. Burrinha, Tatiana; Guimas Almeida, Claudia. "Lysosome function with neuronal aging in vitro". Paper presented in LYSOCIL - Workshop on lysosome biology, 2019.
  23. Perdigão, Catarina; Barata, Mariana; Ana Marques; Burrinha, Tatiana; Almeida, Claudia G. "BIN1 variants increase beta-amyloid intracellular accumulation and affect synapses". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), 2019.
  24. Burrinha, Tatiana; Ricardo Gomes; Ana Paula Terrasso; Guimas Almeida, Claudia. "Lysosome (dys)function with neuronal aging". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences, 2019.
  25. Perdigão, Catarina; Brito, Catarina; Guimas Almeida, Claudia. "Towards a 3D model of late onset Alzheimer's Disease". Paper presented in Towards a 3D model of late onset Alzheimer's Disease, 2019.
  26. Burrinha, Tatiana; Ricardo Gomes; Figueira, Inês; Guimas Almeida, Claudia. "Cellular aging potentiates neuronal beta-amyloid production by increasing APP endocytosis". Paper presented in WORKSHOP ON INTEGRATIVE APPROACHES IN NEURODEGENERATION, 2018.
  27. Perdigão, Catarina; Burrinha, Tatiana; Barata, Mariana; Almeida, Claudia G. "BIN1 overexpression increases beta-amyloid intracellular accumulation". Paper presented in The 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2018.
  28. Burrinha, Tatiana; Ricardo Gomes; Ana Paula Terrasso; Guimas Almeida, Claudia. "Aged neurons endocytose more APP enhancing amyloid-dependent synapse loss". Paper presented in 1st Meeting on Vesicular Biology, 2018.
  29. Burrinha, Tatiana; Ricardo Gomes; Guimas Almeida, Claudia. "Why is aging the major risk factor for beta-amyloid accumulation and Alzheimer's disease development?". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, 2017.
  30. Burrinha, Tatiana; Ricardo Gomes; Guimas Almeida, Claudia. "How is aging altering APP trafficking, beta-amyloid accumulation and synaptic dysfunction?". Paper presented in Synaptic Function and Dysfunction in Brain Diseases, 7th ISN Special Neurochemistry Conference, 2016.
  31. Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Claudia. "Bin1 and CD2AP differentially regulate the endocytic generation of amyloid-beta". Paper presented in Super-resolution microscopy in infection and immunity symposium, 2015.
  32. Guimas Almeida, Claudia. "Significance of intraneuronal Aß accumulation in Alzheimer's disease". 2004.
    10.1016/S0197-4580(04)81463-5
  33. Guimas Almeida, Claudia. "Aß42 accumulation in endosomes is associated with synaptic alterations". 2004.
    10.1016/S0197-4580(04)81464-7
  34. Guimas Almeida, Claudia. "The arctic APP mutation affects Aß production and its site of cellular aggregation in Alzheimer's disease". 2004.
    10.1016/S0197-4580(04)80259-8
  35. Guimas Almeida, Claudia. "Production of oxygen free radicals by xanthine oxidase plus xanthine in hippocampal slices". 2001.
Journal article
  1. Daniel Carnicero-Senabre; Mariana A. Barata; José Jiménez-Villegas; Claudia Guimas Almeida; Antonio Cuadrado; Ana I. Rojo. "NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus". Redox Biology 86 (2025): https://www.sciencedirect.com/science/article/pii/S2213231725003660?via%3Dihub.
    10.1016/j.redox.2025.103853
  2. Mariana A. Barata; Catarina Perdigão; José Ramalho; Edgar R. Gomes; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses". Cell Reports (2025): https://doi.org/10.1016/j.celrep.2025.116005.
    10.1016/j.celrep.2025.116005
  3. Farzaneh S. Mirfakhar; Jorge Castanheira; Raquel Domingues; José S. Ramalho; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin". The Journal of Neuroscience (2024): https://doi.org/10.1523/JNEUROSCI.1734-23.2024.
    Published • 10.1523/JNEUROSCI.1734-23.2024
  4. Sabine C Konings; Emma Nyberg; Isak Martinsson; Laura Torres-Garcia; Oxana Klementieva; Guimas Almeida, Claudia; Gunnar K Gouras. "Apolipoprotein E intersects with amyloid-ß within neurons". Life Science Alliance (2023): https://doi.org/10.26508/lsa.202201887.
    10.26508/lsa.202201887
  5. Tatiana Burrinha; César Cunha; Michael J. Hall; Mafalda Lopes-da-Silva; Miguel C. Seabra; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Deacidification of endolysosomes by neuronal aging drives synapse loss". Traffic (2023): https://doi.org/10.1111/tra.12889.
    10.1111/tra.12889
  6. Domingues, N.; Marques, A.R.A.; Calado, R.D.A.; Ferreira, I.S.; Ramos, C.; Ramalho, J.; Soares, M.I.L.; et al. "Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages". Traffic 24 7 (2023): 284-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-85158007022&partnerID=MN8TOARS.
    10.1111/tra.12888
  7. Duarte C. Barral; Leopoldo Staiano; Cláudia Guimas Almeida; Dan F. Cutler; Emily R. Eden; Clare E. Futter; Antony Galione; et al. "Current methods to analyze lysosome morphology, positioning, motility and function". Traffic 23 5 (2022): 238-269. https://doi.org/10.1111/tra.12839.
    10.1111/tra.12839
  8. Tatiana Burrinha; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Aging impact on amyloid precursor protein neuronal trafficking". Current Opinion in Neurobiology 73 (2022): 102524-102524. https://doi.org/10.1016/j.conb.2022.102524.
    10.1016/j.conb.2022.102524
  9. Mariana Afonso Barata; Catarina Perdigão; Claudia G. Almeida; Barata, Mariana Afonso; Perdigão, Catarina; Burrinha, Tatiana; Almeida, Claudia G. "BIN1 LOAD mutants increase intracellular Aß by interfering with BACE1 recycling". Alzheimer's & dementia : the journal of the Alzheimer's Association 17 (2021): e054178-e054178. https://novaresearch.unl.pt/en/publications/8d8a65b1-7698-4b3c-9dc5-61367aff6227.
    10.1002/alz.054178
  10. Catarina Perdigão; Mariana A. Barata; Tatiana Burrinha; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Alzheimer's disease BIN1 coding variants increase intracellular Aß levels by interfering with BACE1 recycling". Journal of Biological Chemistry 297 3 (2021): 101056-101056. https://doi.org/10.1016/j.jbc.2021.101056.
    10.1016/j.jbc.2021.101056
  11. Claudia Guimas Almeida; Almeida, Claudia Guimas. Corresponding author: Almeida, Claudia Guimas. "Synapses have autophagy under control". Journal of Cell Biology (2021): https://doi.org/10.1083/jcb.202105008.
    10.1083/jcb.202105008
  12. Tatiana Burrinha; Isak Martinsson; Ricardo Gomes; Ana Paula Terrasso; Gunnar K. Gouras; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss". Journal of Cell Science 134 9 (2021): https://doi.org/10.1242/jcs.255752.
    10.1242/jcs.255752
  13. Diógenes, M.J.; Guimas Almeida, C.; Xapelli, S.. "Editorial: Meeting of the Portuguese Society for Neurosciences SPN2019". Frontiers in Molecular Neuroscience 14 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117455505&partnerID=MN8TOARS.
    10.3389/fnmol.2021.753500
  14. Perdigão, Catarina; Barata, Mariana Afonso; Araújo, M.N.; Mirfakhar, farzaneh; Castanheira, Jorge; Guimas Almeida, Claudia. Corresponding author: Guimas Almeida, Claudia. "Intracellular trafficking mechanisms of synaptic dysfunction in Alzheimer's disease". Frontiers in Cellular Neuroscience (2020): https://www.frontiersin.org/articles/10.3389/fncel.2020.00072/abstract.
    Open access • Accepted • 10.3389/fncel.2020.00072
  15. Bettina Winckler; Victor Faundez; Sandra Maday; Qian Cai; Cláudia Guimas Almeida; Huaye Zhang; Winckler, Bettina; et al. "The Endolysosomal System and Proteostasis: From Development to Degeneration". The Journal of Neuroscience 38 44 (2018): 9364-9374. https://doi.org/10.1523/JNEUROSCI.1665-18.2018.
    10.1523/JNEUROSCI.1665-18.2018
  16. Cláudia Guimas Almeida; Farzaneh Sadat Mirfakhar; Catarina Perdigão; Tatiana Burrinha. Corresponding author: Cláudia Guimas Almeida. "Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production". Cellular and Molecular Life Sciences 75 14 (2018): 2577-2589. https://doi.org/10.1007/s00018-018-2825-9.
    10.1007/s00018-018-2825-9
  17. Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Claudia. Corresponding author: Guimas Almeida, Claudia. "Measuring the Endocytic Recycling of Amyloid Precursor Protein (APP) in Neuro2a Cells". BIO-PROTOCOL 7 23 (2017): http://dx.doi.org/10.21769/bioprotoc.2635.
    Published • 10.21769/BIOPROTOC.2635
  18. Florent Ubelmann; Tatiana Burrinha; Laura Salavessa; Ricardo Gomes; Cláudio Ferreira; Nuno Moreno; Cláudia Guimas Almeida. Corresponding author: Cláudia Guimas Almeida. "Bin1 and CD2AP polarise the endocytic generation of beta-amyloid". EMBO reports 18 1 (2017): 102-122. https://doi.org/10.15252/embr.201642738.
    10.15252/embr.201642738
  19. Ubelmann, Florent; Burrinha, Tatiana; Guimas Almeida, Cláudia. Corresponding author: Guimas Almeida, Cláudia. "A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution". BIO-PROTOCOL 7 23 (2017): http://dx.doi.org/10.21769/bioprotoc.2629.
    Open access • Published • 10.21769/bioprotoc.2629
  20. Coudrier E; Almeida CG. "Myosin 1 controls membrane shape by coupling F-Actin to membrane.". BioArchitecture 1 5 (2011): 230-235. http://europepmc.org/abstract/med/22754614.
    Published • 10.4161/bioa.18406
  21. Almeida, Claudia G.; Yamada, Ayako; Tenza, Danièle; Louvard, Daniel; Raposo, Graça; Coudrier, Evelyne. "Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network". Nature Cell Biology 13 7 (2011): 779-789.
    Published • 10.1038/ncb2262
  22. Tampellini, D.; Magrane, J.; Takahashi, R. H.; Li, F.; Lin, M. T.; Almeida, C. G.; Gouras, G. K.. "Internalized Antibodies to the Abeta Domain of APP Reduce Neuronal Abeta and Protect against Synaptic Alterations". Journal of Biological Chemistry 282 26 (2007): 18895-18906.
    Published • 10.1074/jbc.M700373200
  23. Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi; Almeida, Claudia G.; Greengard, Paul; Nyberg, Fred; et al. "The Arctic Alzheimer mutation favors intracellular amyloid-ß production by making amyloid precursor protein less available to a-secretase". Journal of Neurochemistry 101 3 (2007): 854-862.
    Published • 10.1111/j.1471-4159.2006.04443.x
  24. Almeida, C. G.; Takahashi, R. H.; Gouras, G. K.. "beta-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System". Journal of Neuroscience 26 16 (2006): 4277-4288.
    Published • 10.1523/JNEUROSCI.5078-05.2006
  25. Almeida, Claudia G.; Tampellini, Davide; Takahashi, Reisuke H.; Greengard, Paul; Lin, Michael T.; Snyder, Eric M.; Gouras, Gunnar K.. "Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses". Neurobiology of Disease 20 2 (2005): 187-198.
    Published • 10.1016/j.nbd.2005.02.008
  26. Snyder, Eric M; Nong, Yi; Almeida, Claudia G; Paul, Surojit; Moran, Timothy; Choi, Eun Young; Nairn, Angus C; et al. "Regulation of NMDA receptor trafficking by amyloid-ß". Nature Neuroscience 8 8 (2005): 1051-1058.
    Published • 10.1038/nn1503
  27. Gouras, Gunnar K.; Almeida, Claudia G.; Takahashi, Reisuke H.. "Intraneuronal Aß accumulation and origin of plaques in Alzheimer's disease". Neurobiology of Aging 26 9 (2005): 1235-1244.
    Published • 10.1016/j.neurobiolaging.2005.05.022
  28. Stenh, Charlotte; Englund, Hillevi; Lord, Anna; Johansson, Ann-Sofi; Almeida, Claudia G.; Gellerfors, Pär; Greengard, Paul; et al. "Amyloid-ß oligomers are inefficiently measured by enzyme-linked immunosorbent assay". Annals of Neurology 58 1 (2005): 147-150.
    Published • 10.1002/ana.20524
  29. Li, Feng; Calingasan, Noel Y.; Yu, Fangmin; Mauck, William M.; Toidze, Marine; Almeida, Claudia G.; Takahashi, Reisuke H.; et al. "Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice". Journal of Neurochemistry 89 5 (2004): 1308-1312.
    Published • 10.1111/j.1471-4159.2004.02455.x
  30. Gouras, G.; LaFerla, F.; Strobel, G.; Busciglio, J.; Almeida, C.; Geula, C.; Stenh, C.; et al. "Intraneuronal Aß accumulation-more evidence, less controversy? Alzheimer research forum live discussion". Journal of Alzheimer's Disease 6 4 (2004): 443-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-4644273867&partnerID=MN8TOARS.
  31. Takahashi, R. H.; Almeida, C. G.; Patrick F. Kearney; Yu, Fangmin; Lin, Michael T.; Teresa A. Milner; Gouras, Gunnar K.. "Oligomerization of Alzheimer's Aß within processes and synapses of cultured neurons and brain". NEUROBIOLOGY OF AGING 24 14 (2004): 3592-3599.
    Published • 10.1016/S0197-4580(04)80508-6
  32. Almeida, Cláudia G.; de Mendonça, Alexandre; Cunha, Rodrigo A.; Ribeiro, J.Alexandre; Guimas Almeida, Claudia; Ribeiro, Joaquim A.. "Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices". Neuroscience Letters 339 2 (2003): 127-130. http://hdl.handle.net/10451/55413.
    Published • 10.1016/S0304-3940(02)01478-7
  33. Whitaker, C.; Eckman, C.; Almeida, C.; Feinstein, D.; Atwood, C.; Eckman, E.; Crutcher, K.; et al. "Live discussion: Amyloid-ß degradation: The forgotten half of Alzheimer's disease". Journal of Alzheimer's Disease 5 6 (2003): 491-497. http://www.scopus.com/inward/record.url?eid=2-s2.0-9144274938&partnerID=MN8TOARS.
Preprint
  1. Farzaneh S. Mirfakhar; Jorge Castanheira; Raquel Domingues; José S. Ramalho; Cláudia Guimas Almeida. "The Alzheimer’s disease risk gene CD2AP functions in dendritic spines by remodelling F-actin". 2023. https://doi.org/10.1101/2023.08.31.555707.
    10.1101/2023.08.31.555707
  2. Tatiana Burrinha; César Cunha; Cláudia Guimas Almeida. "Deacidification of distal lysosomes by neuronal aging drives synapse loss". 2022. https://doi.org/10.1101/2022.10.12.511921.
    10.1101/2022.10.12.511921
  3. Catarina Perdigão; Mariana Barata; Tatiana Burrinha; Cláudia Guimas Almeida. "Alzheimer’s disease BIN1 coding variants increase intracellular Aß by interfering with BACE1 recycling". 2021. https://doi.org/10.1101/2021.06.09.447716.
    10.1101/2021.06.09.447716
  4. Domingues, N.; Calado, R.D.A.; Brito, P.H.; Matthiesen, R.; Ramalho, J.; Soares, M.I.L.; Pereira, T.; et al. "Cholesteryl hemiazelate induces lysosome dysfunction and exocytosis in macrophages". 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85101189621&partnerID=MN8TOARS.
    10.1101/2021.01.05.422575
  5. Tatiana Burrinha; Ricardo Gomes; Ana Paula Terrasso; Cláudia Guimas Almeida. "Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis". 2019. https://doi.org/10.1101/616540.
    10.1101/616540
Thesis / Dissertation
  1. Castanheira, Jorge. "Understanding the impact of late-onset Alzheimer’s disease mutations in CD2AP on synapses". PhD, 2026. http://hdl.handle.net/10362/199857.
  2. Barata, Mariana Afonso. "Breaking BIN1 : investigating mechanisms of synaptic dysfunction in Alzheimer’s disease". PhD, 2025. http://hdl.handle.net/10362/180461.
  3. "Investigating the Late-Alzheimer’s disease phenotype of CD2AP genetic risk in induced human neurons". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2024. http://hdl.handle.net/10400.5/97335.
  4. Mirfakhar, Farzaneh Sadat. "Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer's disease". PhD, 2023. http://hdl.handle.net/10362/156987.
  5. Burrinha, Tatiana. "Lysosome dysfunction, the link between aging and alzheimer’s disease?". PhD, 2023. http://hdl.handle.net/10362/148989.
  6. Piconêz, Tiago. "Uncovering the mechanism of CD2AP behind Alzheimer’s disease". Master, 2022. http://hdl.handle.net/10362/147637.
  7. Cunha, César Augusto Vogado. "Disclosing lysosomal dysfunction with neuronal aging". Master, 2022. http://hdl.handle.net/10362/137847.
  8. "Perdigão, Catarina. The impact of the genetic risk factor BIN1 to Alzheimer¿s disease development". PhD, 2021.
  9. Araújo, Margarida Nóbrega Campos de Freitas. "Investigating the mechanisms of synaptic dysfunction in late-onset Alzheimer’s disease". Master, 2020. http://hdl.handle.net/10451/48747.
  10. Barata, Mariana Afonso. "Understanding the impact of sporadic Alzheimer’s disease mutations on BIN1". Master, 2019. http://hdl.handle.net/10362/86981.
  11. Marques, Ana Cláudia Monteiro. "The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer’s Disease". Master, 2018. http://hdl.handle.net/10362/54375.
  12. "Oliveira, Luis. Quantitative nanoscopy of endosomal F-actin: Impact of an Alzheimer¿s risk factor". Master, 2018.
  13. "Posada, Adrian. In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy". PhD, Universidade Nova de Lisboa, 2018. https://run.unl.pt/handle/10362/57819?locale=en.
  14. Bravo, Ana Francisca Rodrigues Vaz. "The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases". PhD, 2018. https://hdl.handle.net/1822/56267.
  15. Salavessa, Laura Nunes Soares Sequeira. "Endocytic trafficking mechanisms in Alzheimer's disease : role of the actin regulators bin l and CD2AP". Master, 2015. http://hdl.handle.net/10316/29641.
  16. Ferreira, Cláudio Miguel Letras da Silva, 1987-. "Identification of the cellular and molecular mechanism by which CD2AP, a regulator of neuronal intracellular transport contributes to the development of Alzheimer’s disease". Master, 2014. http://hdl.handle.net/10451/15737.
  17. Burrinha, Tatiana Marisa Andrade. "Bridging integrator 1 (BIN1) controls beta-amyloid accumulation in Alzheimer`s desease". Master, 2014. http://hdl.handle.net/10362/19898.
  18. Guimas Almeida, Claudia; Almeida, Cláudia Guimas de, 1976-; Almeida, Claudia G. "ß-amyloid-dependent neuronal dysfunction and effect on the endocytic pathway". PhD, 2007. http://hdl.handle.net/10451/6401.

Other

Other output
  1. Erratum. Correction: Apolipoprotein E intersects with amyloid-ß within neurons (Life science alliance (2023) 6 8 PII: e202402875 DOI: 10.26508/lsa.202201887). 2024. Sabine C. Konings; Emma Nyberg; Isak Martinsson; Laura Torres-Garcia; Oxana Klementieva; Claudia Guimas Almeida; Gunnar K. Gouras. https://novaresearch.unl.pt/en/publications/229717e6-b383-4515-b23d-89897645f773.
    10.26508/lsa.202402875
  2. Therapeutic Targeting of Nrf2 in Alzheimer's Disease. 2024. D Carnicero-Senabre; MA Barata; CG Almeida; A Cuadrado; AI Rojo. https://novaresearch.unl.pt/en/publications/f557c4f0-169c-4acb-8395-f811ea16217b.
    10.1016/j.freeradbiomed.2024.04.017
  3. EHD proteins mediate ubiquitin-dependent recycling of gap junctions (GJs) in the ischemic heart. 2019. Tania Martins Marques; Steve Catarino; Claudia G. Almeida; Henrique Girao; Almeida, Claudia G. https://novaresearch.unl.pt/en/publications/d088f968-59c0-4dc2-8dc3-0e21aa13a564.
  4. EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia. 2018. T. Martins-Marques; S. Catarino; C. G. Almeida; H. Girao. https://novaresearch.unl.pt/en/publications/bc1a1edc-94f8-455b-861a-96cc4c8c82d5.
  5. Actin control of endosomal sorting in neurons: impact on Alzheimer's disease.. 2017. C. Guimas Almeida; L. Salavessa; L. Oliveira; Almeida, Claudia G; Salavessa, Laura Nunes Soares Sequeira. https://novaresearch.unl.pt/en/publications/655ac1c2-fb31-4934-aa8b-74c59fb9c0df.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2026 BIN1 drives AD-like neuronal hyperexcitability by eliminating inhibitory synapses ADPD2026
(Denmark)
2025 BIN1 drives AD-like neuronal hyperexcitability by eliminating inhibitory synapses Alzheimer’s Association International Conference (AAIC 2025)
Alzheimer’s Association (Philadelphia, United States)
2025 Alzheimer at the cellular level: when endosomes fail, synapses suffer II Congresso do Algarve de Alzheimer e Outras Demências
(Castro Marim, Portugal)
2025 Alzheimer at the cellular level: when endosomes fail, synapses suffer GIMM – Neuroscience Seminar
GiMM (Lisbon, Portugal)
2025 Endosomal dysfunction and ß-amyloid in late-onset Alzheimer’s disease Norwegian Dementia / ADTC Seminar
NTUC (Trondheim, Norway)
2025 Alzheimer at the cellular level: when endosomes fail, synapses suffer GEECD / SPN Joint Meeting
GEECD / SPN (Coimbra, Portugal)
2025 BIN1-dependent synaptic dysfunction in Alzheimer’s disease Portuguese Society for Neurosciences (SPN) Annual Meeting 2025
SPN (Portugal)
2025 BIN1 and synaptic vulnerability in late-onset Alzheimer’s disease 3rd Symposium on Alzheimer’s Disease
FEP (Portugal)
2024/10/10 Endosomal trafficking defects in brain aging and Alzheimer’s disease XXII SPB National Congress of Biochemistry, 2024
(Portugal)
2024/04/17 Endolysosomal system dysfunction in neurons during Aging and Alzheimer's disease IB Conference 2024
Institute of Biomembranes, Utrecht University (Utrecht, Netherlands)
2024/03/20 Endolysosomal system dysfunction in neurons during Aging and Alzheimer's disease Seminar
Gotheburg University (Gotheburg, Sweden)
2024 CD2AP MAY CONTRIBUTE TO ALZHEIMER'S DISEASE SYNAPSE DYSFUNCTION BY DISRUPTING THE ACTIN CYTOSKELETON IN DENDRITIC SPINES ADPD2024
(Lisboa, Portugal)
2023 The late-onset Alzheimer's disease risk factor CD2AP may impact synapses independently of beta-amyloid. 37ª Reunião anual do Grupo de Estudos de Envelhecimento cerebral e Demência
Grupo de Estudos de Envelhecimento cerebral e Demência (Portugal)
2023 Imaging the Endolysosomal System Dysfunction in the normal aging brain: relevance for age-dependent synapse loss FENS Regional Meeting: FRM 2023
FENS (Portugal)
2022 . Endosomal trafficking defects in aging and Alzheimer’s disease increase intracellular beta-amyloid AD/PD 2022
ADPD (Spain)
2022 Neuronal trafficking defects during normal aging Ageing Spring School 2022
MIA-Portugal (Portugal)
2022 Endosomal trafficking defects in aging and alzheimer’s disease increase intracellular beta-amyloid AD/PD2022
ADPD (Spain)
2022 Investigating the causal mechanisms of late-onset Alzheimer's disease ABC Days - V Encontro Anual do Algarve Biomedical Center
Algarve Biomedical Center (Portugal)
2022 Neuronal trafficking defects during normal aging Seminar
King's College London (United Kingdom)
2022 Imaging Alzheimer’s Endosomal Defects at single synapses Institute Seminar
Marine biological Laboratory (WoodsHole, United States)
2021 Investigação básica em Neurociências Curso de Introdução à Investigação Científica
nowScience
2021 Alzheimer: What has already been discovered and what is yet to be discovered? I SCORE Symposium
AEFCM (Portugal)
2021 Impacto do Tráfego Intracelular no Alzheimer Under A Biomedical Eye
NEBM-IST (Portugal)
2021 Mechanisms of Neuronal Aging relevant for Alzheimer’s disease Neuroscience seminar
iMM (Portugal)
2021 Symposium talk: ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID Portuguese Society for Neurosciences Bi-Annual meeting
Portuguese Society for Neurosciences (Portugal)
2021 ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID Seminar
Achucarro Neuroscience center (Spain)
2021 ENDOSOMAL TRAFFICKING DEFECTS IN AGING AND ALZHEIMER’S DISEASE INCREASE INTRACELLULAR BETA-AMYLOID SynAge Seminar
Institute of Biology, Department for Molecular Neurobiology and Genetics (Germany)
2019 Impact of late-onset Alzheimer’s disease risk factors on synapses Synaptic Function, Dysfunction and Repair Workshop
UCL & The Discoveries Centre for Regenerative and Precision Medicine (Lisboa, Portugal)
2019 Impact of late-onset Alzheimer’s disease risk factors on synapses Seminar
U Catolica (Santiago, Chile)
2019 Actin control of neuronal endosomal sorting: implications for Alzheimer's disease EMBO Workshop "Neuronal Cytoskeleton"
EMBO (Chile)
2019 Endosomal trafficking defects in aging and Alzheimer’s Disease ADPD 2019
https://adpd.kenes.com/2019 (Lisboa, Portugal)
2018 Endosomal trafficking defects and Alzheimer’s Disease Mini-Symposium "Membrane Trafficking: from development to degeneration" SFN 2018, Nov 2018, San Diego
SFN 2018 (United States)
2018 Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease Seminar
Achucarro Basque Center for Neurosciences (bilbao, Spain)
2018 Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease Seminar
Centre de Psychiatries et Neurosciences (Paris, France)
2018 Endosomal trafficking defects in aging and Alzheimer's disease Biochemistry department seminar
U Toronto (Toronto, Canada)
2018 Actin control of endosomal sorting in neurons: implications for Alzheimer's disease 9th Meeting Signal Transduction
(Lisbon, Portugal)
2018 Cellular Aging impairs synapses via beta-amyloid accumulation and APP endocytosis Society for Neuroscience 2018
(San Diego, United States)
2017 Proteostasis in Alzheimer’s disease EMBO Workshop "Proteostasis"
EMBO (Ericeira, Portugal)
2017 The Alzheimer's risk factors Bin1 and CD2AP polarize the endocytic generation of ß-amyloid EMBO Conference on Molecular Mechanisms of Neurodegeneration
(Heidelberg, Germany)
2017 Mechanisms of beta-amyloid endocytic production in late-onset Alzheimer's disease World Alzheimer Global Summit
(Lisbon, Portugal)
2015 The Alzheimer’s risk factors BIN1 and CD2AP differentially control the endocytic generation of ß-amyloid Seminar
CIMR (Cambridge, United Kingdom)
2015 Investigating the contribution of endocytic trafficking defects to Alzheimer’s disease development CNC seminar
Seminar (Coimbra, Portugal)
2015 Investigating the contribution of endocytic trafficking defects to Alzheimer´s disease development “Pathogenesis of Neurodegenerative Disorders – found a common ground” course 20-24 April 2015
ICVS (Braga)
2015 The Alzheimer's risk factors Bin1 and CD2AP differentially regulate the endocytic generation of amyloid-ß Society for Neuroscience 2015
(Chicago, United States)
2014 How are regulators of intracellular trafficking risk-factors for Alzheimer´s disease? iMM Monday lectures
iMM (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current PHD: Investigating the prevalence of clinical presentation related to seizures in carriers of late-onset Alzheimer’s disease BIN1 risk variants.
Supervisor
 PhD in Epidemiology (PhD)
2023 - Current PHD: The links between BAR domain proteins endophilin-A and BIN1 and neurodegeneration
Co-supervisor
2020 - 2026/01 PHD: : Understanding the impact of late-onset Alzheimer’s disease mutations in CD2AP on synapses.
Supervisor
 PhD in Health Sciences (PhD)
2020 - 2025 PHD: Breaking BIN1: Investigating mechanisms of synaptic dysfunction in Alzheimer’s disease
Supervisor
 Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2023 PHD: Association of the Endocytic Trafficking Regulator CD2AP Gene Variant K633R And the Risk of Developing Alzheimer’s Disease.
Supervisor
2018/10 - 2022/06 PHD: Lysosomes dysfunction, the link between Aging and Alzheimer´s disease?
Supervisor
2020 - 2022 MASTER: Investigating mechanisms of lysosome dysfunction with aging
Supervisor of César Cunha
2017 - 2021/12 PHD: The impact of the genetic risk factor BIN1 to Alzheimer's disease development
Supervisor
 Ph.D. program in Bioengineering – Cell Therapies and Regenerative Medicine (PhD)
2019 - 2021 MASTER: Investigating the mechanisms of synaptic dysfunction in late-onset Alzheimer's disease
Supervisor of Margarida Araújo
 Molecular Biology and Genetics (Master)
2018 - 2019 MASTER: Understanding the impact of sporadic Alzheimer’s disease mutations on BIN1
Supervisor
2016 - 2019 PHD: HEART ISCHEMIA GIVES A SECOND LIFE TO CX43 NOVEL ROLES ASCRIBED TO CX43 THAT GO BEYOND GAP JUNCTION INTERCELLULAR COMMUNICATION
Co-supervisor
2017 - 2018 MASTER: The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer's Disease
Supervisor
2014 - 2018 PhD: In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy
Co-supervisor
2014 - 2018 PHD: Neural cell models for disease modeling and drug discovery Exploiting 3D differentiation of human stem cells
Co-supervisor
2014 - 2018 PHD: The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases
Co-supervisor
2014 - 2015 MASTER: Endocytic trafficking mechanisms in Alzheimer´s disease: role of the actin regulators bin l and CD2AP
Supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2014 MASTER: Bridging Integrator 1 (BIN1) controls beta-amyloid accumulation in Alzheimer's disease
Supervisor
2013 - 2014 MASTER: Identification of the cellular and molecular mechanism by which CD2AP, a regulator of neuronal intracellular transport contributes to the development of Alzheimer's disease.
Supervisor

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - Current Representing non-tenure NMS Researchers (2023) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023 - Current ADPD 2024 - Advisory Board (2024/03)
Congress (Member of the Scientific Committee)
2021 - Current Lysocil Summer School: Lysosome and Cilia interactions (2021 - 2021)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019 - Current Lysosome Workshop - within the activities of the Twinning project LYSOCIL (2019)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2020 The organizer of CEDOC's Casual Friday seminars (2018)
Seminar
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019 - 2019 Co-organizer of the 2019 Meeting of the Portuguese Society for Neurosciences (2019 - 2019)
Congress (Co-organisor)
 Sociedade Portuguesa de Neurociências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022 - Current PintofScience Portugal, O Que causa a doença de Alzheimer?, Cabecinha Pensadora
Meeting
 Cabecinha Pensadora
2020 - Current Araújo, M.N., Mirfakhar, F.S., Almeida, C.G. “Impact of a late-onset Alzheimer’s disease CD2AP mutation on intracellular amyloid-beta production”. AstraZeneca Foundation Innovate Competition
Congress
 iMed Conference 12.0
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Perdiga~o, Catarina; Brito, Catarina; Almeida, Claudia G. "Towards a 3D model of late-onset Alzheimer's Disease". Poster presented in NOVA Science Day, 2019.
Congress
 NOVA Science Day

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023 Axonal transport
(Thesis) Main arguer
 João Machado (Master)
Universidade de Coimbra, Portugal
2023 Proteostasis and exosomes
Thesis Member
 Catarina Meyer (PhD)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023 Alzheimer's disease human adult cellular models
(Thesis) Main arguer
 Katrine Hanssen (PhD)
Norges teknisk-naturvitenskapelige universitet, Norway
2021 CHARACTERIZATION OF THE RHO GTPASE ACTIVATING PROTEIN, ARHGAP8, IN THE CENTRAL NERVOUS SYSTEM
(Thesis) Main arguer
 Jeannette Schmidt (PhD)
Universidade de Coimbra, Portugal
2019 Regulation of cellular signalling by trafficking control
(Thesis) Arguer
 Ioanna Oikonomidi (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto Gulbenkian de Ciência, Portugal
2019 UNRAVELING THE MECHANISMS OF NEURONAL DEVELOPMENT IN THE HIPPOCAMPUS
(Thesis) Main arguer
 Susana Sampaio (PhD)
Universidade de Coimbra, Portugal
2019 Klotho: relevance in the control of neuroinflammation in Parkinson’s disease
(Thesis) Main arguer
 Rui Jorge Januário Gaspar (Master)
Universidade da Beira Interior, Portugal
2018 UNVEILING THE ROLE OF MIRNAS IN SYNAPTIC PLASTICITY
(Thesis) Main arguer
 Mariline Mendes Silva (PhD)
2017 Characterizing Alzheimer’s Amyloid Precursor Protein (APP) neurotrophic functions
(Thesis) Main arguer
 Joana Rocha (PhD)
Universidade de Aveiro, Portugal
2016 Dissecting the role of the Ral/Exocyst pathway in postsynaptic growth and activity-dependent plasticity
(Thesis) Arguer
 Cátia Filipa Patrício Rodrigues (Master)
Universidade Nova de Lisboa, Portugal
2015 Novel in vitro human 3D neural model derived from induced pluripotent stem cells
(Thesis) Main arguer
 Francisca Maria de Andrade Terras Arez (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 The role of the endocytic and autophagic molecular machineries in the removal of apoptotic cells
(Thesis) Main arguer
 Michelle Viegas (PhD)
Universidade de Coimbra, Portugal
2014 Exploring deregulated signals involved in Motor neuron-Microglia cross-talk in ALS
(Thesis) Main arguer
 Maria Inês Fazendeiro Cunha (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Journal of Cell science
2023 - Current Brain Aging
2023 - Current Alzheimer's and Dementia
2022 - Current Journal Cellular Phisiology
2022 - Current Science Advances
2022 - Current Pharmacological Research
2022 - Current Neurotoxicity Research
2022 - Current Autophagy
2021 - Current Cells
2020 - Current Acta Neuropathologica Communications
2020 - Current Molecular Neurobiology
2020 - Current Plos Neglected Diseases
2020 - Current Scientific Reports
2019 - Current Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2019 - Current Cytoskeleton (1949-3592) Wiley (John Wiley & Sons)
2019 - Current EMBO Reports (1469-3178) EMBO
2019 - Current FEBS Letters (1873-3468) Wiley (John Wiley & Sons)
2018 - Current Neurobiology of Aging (0197-4580) Elsevier
2018 - Current Neurochemical Research (1573-6903) Springer-Verlag
2018 - Current PLoS ONE (1932-6203) Public Library of Science
2017 - Current Frontiers in Molecular Neuroscience (1662-5099) Frontiers Media SA
2017 - Current Journal of Alzheimer s Disease (1875-8908) IOS Press
2017 - Current Molecular and Cellular Neuroscience (1095-9327) Elsevier

Association member

Society Organization name Role
2021 - Current COST ACTION: CA20121 - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases member of WG1 - Tools for NRF2 research.
2015 - Current International Society for Neurochemistry
2009 - Current SPN - Portuguese Society of Neurosciences
2007 - Current Club exo-endocytosis
2004 - Current American Society for Cell Biology
2003 - Current Society for Neurosciences
2002 - Current Alzforum.org
2000 - Current ANBIOQ
1998 - Current Sociedade Portuguesa de Bioquímica

Committee member

Activity description
Role 		Institution / Organization
2024 - Current Biomedicine FCT panel for PhD fellowships
Member
2023 - Current NMS Research Committee
Member
 Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022 - Current Recruitment Juri: Technician in Bioimaging,
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - Current Recruitment Juri: International recruitment of Assistant Researcher in Neurosciences
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Current Recruitment Juri: International recruitment of Junior Researcher in Neurosciences, i3S, Porto
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021 - Current Scientific Council - representative of iNOVA4Health researchers
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - Current Scientific Council member
Member
 Universidade NOVA de Lisboa NOVA Medical School, Portugal

Conference scientific committee

Conference name Conference host
2024 - Current ADPD2024 ADPD
2023 - Current PIATI conference NOVA Medical School, Lisbon
2015 - 2019 iMED NOVA Medical School

Consulting

Activity description Institution / Organization
2013 - Current Scientific coordinator of CEDOC's Imaging platform Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2013 - 2023 Scientific coordinator of CEDOC's Imaging platform Universidade NOVA de Lisboa NOVA Medical School, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Lectures, Tutor; PhD program Health Sciences (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - Current Critical Skills in Research - NBR course Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2033 co-organized RARE DISEASES AND NEURODEGENERATION ADVANCED COURSE – PhD program Health Sciences (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

EIT Health, Germany
2022 - 2033 co-organized Molecular and Cellular Mechanisms of Aging ADVANCED COURSE – PhD program Health Sciences, NMS. AGING (Doutoramento)
2021 - 2022 Research Project Course – MIM – Integrated Master in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018 seminar and tutor; Neurodegenerative disease; Molecular Mechanisms of Disease – MIM – Integrated Master in Medicine
2016 - 2018 Research Seminars course director - NBR Master (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2016 Contributed lectures – Neuroscience course, BSc Life Sciences Neurosciences Universidade do Algarve - Campus de Gambelas, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024 - Current Panel committee Neurodegenerative diseases Call 2024 Fondation pour la Recherche Médicale, France
2023 - Current External Reviewer
Evaluator
 Agence nationale de la recherche, France Agence nationale de la recherche
2020 - Current Panel committee
Evaluator
 Alzheimer's Association, United States Alzheimer's Association
2020 - Current External reviewer
Evaluator
 Alzheimer Research Foundation, Belgium Alzheimer Research Foundation
2020 - Current External Reviewer
Evaluator
 Alzheimer Research UK, United Kingdom Alzheimer Research UK
2019 - Current External reviewer
Evaluator
 The Czech Science Foundation (GACR), Czech Republic The Czech Science Foundation (GACR)
2018 - Current External Reviewer Alzheimer Research Foundation, Belgium Alzheimer Research Foundation
2018 - Current External Reviewer
Evaluator
 Association France Alzheimer et Maladies Apparentées, France Association France Alzheimer et Maladies Apparentées
2018 - Current External Reviewer
Evaluator
 Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium Fonds Wetenschappelijk Onderzoek Vlaanderen
2017 - Current Reviewer - PePita
Evaluator
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
2017 - Current Pfizer award reviewer Pfizer Portugal
2017 - Current Selection Committee of master students for the NOVA Biomedical Research master - NBR
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - Current External reviewer
Evaluator
 Alzheimer's Association, United States Alzheimer's Association

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021 “Dados fracos, custos elevados. A polémica aprovação do medicamento para o Alzheimer” Observador
2021 Equipa portuguesa faz descoberta que pode travar a doença de Alzheimer, Uma equipa de investigadores portugueses identificou um novo mecanismo associado aos neurónios envelhecidos Zap Notícias
2021 https://www.publico.pt/2021/06/19/ciencia/noticia/alzheimer-ha-nova-pista-neuronios-velhos-perdem-sinapses-1966895 Publico

Interview (tv / radio show)

Program Topic
2023 - Current RTP1 documentary "100 ou +" by Farol de ideias Aging
2023 - Current 90 segundos de ciência - RTP podcast - Ep.30 Science

Mentoring / Tutoring

Topic Student name
2025 - Current Thesis committee Ana Rita Ferreira Fernandes
2017 - 2024 Supervision of 21 Bachelor projects Many students
Distinctions

Award

2024 Alzheimer's Association conference fellowship
Alzheimer's Association, United States
2022 1st Edition | International Blended Learning Award 2022- Health and Wellbeing is Critical Skills in Research, with P. Pereira and R. Teodoro,
Universidade Nova de Lisboa, Portugal
2018 FLAD Travel Grant
Fundação Luso-Americana, Portugal
2018 SPN Travel Grant
Sociedade Portuguesa de Neurociências, Portugal
2017 Award Maratona da Saúde Neurodegenerative Diseases 2016
Maratona da Saúde/Biogen, Portugal
2016 Honorable mention, Award Criostaminal 2016
Criostaminal, Portugal
2015 Award Santander/Totta and Universidade NOVA de Lisboa, 2015
Banco Santander Totta, Portugal

Universidade Nova de Lisboa, Portugal
2010 WICB Childcare Grant for ASCB 2010
American Society of Cell biology, United States
2004 Travel Fellowship for the 9th International Conference on Alzheimer's Disease and Related Disorders

Other distinction

2017 CEEC Individual
Fundação para a Ciência e a Tecnologia, Portugal
2013 Investigator FCT
Fundação para a Ciência e a Tecnologia, Portugal
2011 Curie International Post-doc Fellowship
Institut Curie, France
2009 Marie Curie post-doctoral fellowship
Marie Curie Actions, Portugal
2007 EMBO long-term fellowship
EMBO, Portugal
2002 FCT PhD fellowship (SFRH/BD/6270/2001)
Fundação para a Ciência e a Tecnologia, Portugal
2001 FCT Master Fellowship (SFRH/BM/2096/2000)
Fundação para a Ciência e a Tecnologia, Portugal