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Identification

Personal identification

Full name
Eunice Ribeiro João Silva Paisana

Citation names

  • Paisana, Eunice

Author identifiers

Ciência ID
C91E-84E5-4636
ORCID iD
0000-0001-5915-8556

Email addresses

  • epaisana@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • (+351) 217999411 Ext.: 47216 (Professional)

Addresses

  • Instituto de Medicina Molecular de Lisboa, Faculdade de Medicina da Universidade de Lisboa; Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2017/01 - 2024/01/12
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Ciências Biopatológicas
Universidade de Lisboa Faculdade de Medicina, Portugal
"UBE2C promotes leptomeningeal dissemination and can be therapeutically targeted." (THESIS/DISSERTATION)
2020/10 - 2021/01
Concluded
 PAE Medical Science Liason (Outros)
Centro de Estudos Superiores da Indústria Farmacêutica Unipessoal Lda, Portugal
2016/12
Concluded
 Cancer Immunology and Biotechnology (Master)
University of Nottingham, United Kingdom
"T cell recognition of OVA257-264(SIINFEKL) peptide on endothelial MHC class I molecules increase T cell infiltration into tumours: Design of an experimental model " (THESIS/DISSERTATION)
2014
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2018/02 - 2018/03 Visiting Researcher (Research) Instituto de Medicina Molecular, Portugal
Universitätsklinikum Düsseldorf, Germany
2015/05/01 - 2016/08/31 Research Trainee (Research) Instituto de Medicina Molecular, Portugal
2014/05 - 2015/08 Research Trainee (Research) Instituto de Medicina Molecular, Portugal

Others

Category
Host institution 		Employer
2023/08 - Current Clinical Project Manager at Brain Cancer Dynamics and Therapy Translational Lab Instituto de Medicina Molecular, Portugal
2023/08 - Current Lab Manager at Brain Cancer Dynamics and Therapy Translational Lab Instituto de Medicina Molecular, Portugal
2022/05 - Current Management of scientific research dissemination pages (Instagram and LinkedIn) of BTT-CITC Instituto de Medicina Molecular, Portugal
2017/01 - 2024/01/12 PhD Student Instituto de Medicina Molecular, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
(...)
Projects

Contract

Designation Funders
2023/08 - Current IMM-CARE
101060102
Clinical Project Manager
Ongoing
2018 - Current Using genomics to identify novel targeted therapies in brain metastases
PTDC/MED-ONC/32222/2017
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Carlos Custódia; Cascão, Rita; Paisana, Eunice; Daniel Picard; Marc Remke; João T. Barata; Claudia C. Faria. "Inhibition of CCR2 as a potential therapeutic approach for medulloblastoma.". Paper presented in III ASPIC- ASEICA international meeting, 2023.
  2. Carlos Custódia; Cascão, Rita; Paisana, Eunice; Daniel Piccard; Marc Remke; João T. Barata; Claudia C. Faria. "CCR2 as a potential therapeutic target to treat medulloblastoma.". Paper presented in EMBO Young Scientists¿ Forum, 2023.
  3. Paisana, Eunice; Cascão, Rita; Carlos Custódia; Nan Qin; Daniel Picard; David Pauck; Tânia Carvalho; et al. "UBE2C promotes brain metastatic disease and can be a therapeutic target.". Paper presented in EMBO Young Scientists Forum, 2023.
  4. Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Qin, Nan; Picard, Daniel; David Pauck; Carvalho, Tânia; et al. "Targeting the PI3K-mTOR pathway to treat UBE2C-driven brain metastases". Paper presented in Joint SNO/ASNO Conference on CNS Clinical Trials and Brain Metastases, 2022.
  5. Cascão, Rita; Custodia, Carlos; Paisana, Eunice; Cortes-Ciriano, Isidro; Barata, Joao T.; Claudia C. Faria. "Patient-derived models of brain metastases are useful tools for preclinical evaluation of anticancer therapies". Paper presented in Innovative cancer Science - EACR, 2022.
  6. Custodia, Carlos; Cascão, Rita; Paisana, Eunice; et al.. "Targeting the CCL2/CCR2 axis in metastatic meduloblastoma". Paper presented in XV CAML· V NeurULisboa PhD Students Meeting, 2022.
  7. Paisana, Eunice; Cascão, Rita; Carlos Custódia; Nan Qin; Daniel Picard; David Pauck; Tânia Carvalho; et al. "Ubiquitin Conjugating Enzymes promote leptomeningeal dissemination and decrease survival in patients with brain metastatic disease". Paper presented in SNO 3rd Annual Conference on Brain Metastases, 2021.
  8. Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Nan Qin; Daniel Picard; Tânia Carvalho; Pedro Pereira; et al. "The role of ubiquitin conjugating enzymes in brain metastases". Paper presented in EACR Cancer Genomics 2019, Cambridge, UK, 2019.
  9. Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Nan Qin; Daniel Picard; Tânia Carvalho; Pedro Pereira; et al. "The role of ubiquitin conjugating enzymes in brain metastases". Paper presented in XIII CAML PhD Students Meeting 2019, 2019.
  10. Lena Blümel; Kornelius Kerl; Nan Qin; Johannes Berlandi; Katharina Thiel; Isabel Tegeder; Astrid Jeibman; et al. "ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS". Paper presented in Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, 2019.
  11. Nan Qin; Maike Langini; Daniel Picard; Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Frauke Meyer; et al. "BIOL-02. CELLULAR HETEROGENEITY CONTRIBUTES TO THE AGGRESSIVE BEHAVIOR OF MYC-DRIVEN MEDULLOBLASTOMA". Paper presented in Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, 2019.
  12. David Pauck; Paisana, Eunice; Cascão, Rita; Sevgi Sarikaya-Seiwert; Viktoria Marquardt; Daniel Picard; Jasmin Bartl; et al. "EPEN-08. PHARMACOGENOMICS REVEALS ERBB2 AS A THERAPEUTIC TARGET IN PRIMARY EPENDYMOMA CULTURES". Paper presented in Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, 2019.
  13. Nan Qin; Langini, Maike; Picard, Daniel; Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Meyer, Frauke-Dorothee; et al. "Cellular heterogeneity drives aggressive tumorigenesis in MYC-driven medulloblastoma". Paper presented in SNO Pediatric Neuro-Oncology Basic and Translational Research Conference, 2019.
  14. Paisana, Eunice; Custodia, Carlos; Cascão, Rita; Nan Qin; Daniel Picard; Tânia Carvalho; Pedro Pereira; et al. "The role of ubiquitin conjugating enzymes in brain metastases". Paper presented in XI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia, 2019.
  15. Cascão, Rita; Custodia, Carlos; Paisana, Eunice; Tânia Carvalho; Pedro Pereira; José Pimentel; José Miguéns; João T Barata; Claudia C Faria. "Patient-derived xenografts of brain metastases: a tool for translational medicine". Paper presented in EuroPDX Workshop, 2018.
  16. Eunice Paisana; Custodia, Carlos; Cascão, Rita; Nan Qin; Daniel Picard; Tânia Carvalho; Pedro Pereira; et al. "The role of ubiquitin conjugating enzymes in brain metastases". Paper presented in XII CAML PhD Students' Meeting, 2018.
  17. Custodia, Carlos; Paisana, Eunice; Cascão, Rita; Joao T Barata; Claudia C Faria. "An intracardiac patient-derived xenograft model of brain metastases". Paper presented in X Neurooncologia, Encontro Anual da Associação Portuguesa de Neurooncologia, 2017.
Journal article
  1. Qin, Nan; Paisana, Eunice; Picard, Daniel; Leprivier, Gabriel; Langini, Maike; Custódia, Carlos; Cascão, Rita; et al. "The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma". Journal of Neuro-Oncology 165 2 (2023): 329-342. http://dx.doi.org/10.1007/s11060-023-04508-y.
    Published • 10.1007/s11060-023-04508-y
  2. Domentean, Stefani; Paisana, Eunice; Cascão, Rita; Faria, Claudia C.. Corresponding author: Cascão, Rita. "Role of UBE2C in Brain Cancer Invasion and Dissemination". International Journal of Molecular Sciences 24 21 (2023): 15792. http://dx.doi.org/10.3390/ijms242115792.
    Published • 10.3390/ijms242115792
  3. Eunice Paisana; Rita Cascão; Carlos Custódia; Nan Qin; Daniel Picard; David Pauck; Tânia Carvalho; et al. "UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease". Neuro-Oncology Advances (2023): https://doi.org/10.1093/noajnl/vdad048.
    10.1093/noajnl/vdad048
  4. Blümel, Lena; Qin, Nan; Berlandi, Johannes; Paisana, Eunice; Cascão, Rita; Custódia, Carlos; Pauck, David; et al. "Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors". Cell Death & Disease 13 9 (2022): http://dx.doi.org/10.1038/s41419-022-05243-4.
    10.1038/s41419-022-05243-4
  5. Faria, Claudia C.; Cascão, Rita; Custódia, Carlos; Paisana, Eunice; Carvalho, Tânia; Pereira, Pedro; Roque, Rafael; et al. "Patient-derived models of brain metastases recapitulate human disseminated disease". Cell Reports Medicine 3 5 (2022): 100623. http://dx.doi.org/10.1016/j.xcrm.2022.100623.
    Open access • Published • 10.1016/j.xcrm.2022.100623
  6. Qin, Nan; Paisana, Eunice; Langini, Maike; Picard, Daniel; Malzkorn, Bastian; Custódia, Carlos; Cascão, Rita; et al. "Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis". Neuro-Oncology (2022): http://dx.doi.org/10.1093/neuonc/noac068.
    10.1093/neuonc/noac068
  7. Cascão, Rita; Vidal, Bruno; Lopes, Inês P.; Paisana, Eunice; Rino, José; Moita, Luis F.; Fonseca, João E.. "Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats". PLOS ONE 10 12 (2015): e0142448. http://dx.doi.org/10.1371/journal.pone.0142448.
    10.1371/journal.pone.0142448
Preprint
  1. Paisana, Eunice; Cascão, Rita; Custódia, Carlos; Qin, Nan; Picard, Daniel; Pauck, David; Carvalho, Tânia; et al. Corresponding author: Cláudia C Faria. "UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease". 2022. http://dx.doi.org/10.1101/2022.10.04.510674.
    10.1101/2022.10.04.510674
Thesis / Dissertation
  1. "UBE2C promotes leptomeningeal dissemination and can be therapeutically targeted". PhD, Universidade de Lisboa Faculdade de Medicina, 2024.
  2. Paisana, Eunice. "T cell recognition of OVA257-264(SIINFEKL) peptide on endothelial MHC class I molecules increase T cell infiltration into tumours: Design of an experimental model". Master, University of Nottingham, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/27 UBE2C drives leptomeningeal dissemination in brain metastatic disease and is a promising therapeutic target III ASPICASEICA International Meeting – Cancer Immunology, Tumor Microenvironment and Metastasis
2023/02/03 PI3K/mTOR inhibition decreases UBE2C-driven leptomeningeal dissemination XIII APNO
(Portugal)
2022/11/15 UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease 6ª Conferência Anual da redeSAÚDE – Perspetivas Multidisciplinares e Saúde Global na Ulisboa
Universidade de Lisboa (Lisboa, Portugal)
2021/05 Ubiquitin conjugating enzymes promote leptomeningeal dissemination and decrease survival in brain metastatic disease XIV CAML IV NeurULisboa PhD Students
(Lisboa, Portugal)
2021/05 Ubiquitin Conjugating Enzymes promote aggressive metastatic brain disease and decrease patients' survival. 27th Porto Cancer Meeting – Stemness and metastasis: advances in research and clinical translation
2020/09/25 The role of ubiquitin conjugating enzymes in brain metastases. Webinar - Cancer Biology: From Basic To Translational Research
Liga Portuguesa Contra o Cancro (Lisboa, Portugal)
2020/05 Targetting CCL2-CCR2 axis in metastatic medulloblastoma XIII Annual CAML PhD Students’ Meeting
(Portugal)
2019/05 The role of ubiquitin conjugating enzymes in brain metastases 35º Congresso Nacional da Sociedade Portuguesa de Neurocirurgia
(Lisboa, Portugal)
2018/05 Patient-derived xenograft models of brain metastases for translational medicine 3rd ASPIC International Meeting
(Lisboa, Portugal)
2017/05 Identification and validation of genetic drivers of brain metastases XI CAML PhD Students' Meeting
(Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06 - 2023/09/29 European Researchers' Night (2023/09/29)
2019/06 - 2019/09 European Researchers' Night (2019/09/27)
Exhibition (Member of the Organising Committee)
2018/06 - 2018/09 European Researchers' Night (2018/09/28)
Exhibition (Member of the Organising Committee)
2017/04 - 2018/05 XIII CAML PhD Students' Meeting, 2019; Description: Annual meeting for the presentation and discussion of all PhD Students' projects being developed at Instituto de Medicina Molecular and Faculdade de Medicina da Universidade de Lisboa/ Keynote speakers: - Fátima Carneiro, MD, PhD - Miguel Nicolelis, MD, PhD - Marino Zerial, PhD/ Round table on "Open Science" - Maria Manuel Mota, PhD - Marcia Triunfol, PhD - Pedro L. Fernandes, BSc - Pedro Príncipe, BSc (2018/05/15 - 2018/05/17)
Congress (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017/06 - 2017/09/29 European Researchers' Night (2017/09 - 2017/09/29)
Exhibition (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/06/28 - 2019/06/29 Brain Metastasis Research Symposium: From Basic Science to Clinics 2019
Congress
 Brain Metastasis Research Symposium: From Basic Science to Clinics 2019
Medical University of Vienna Center for Brain Research, Austria

Committee member

Activity description
Role 		Institution / Organization
2023/09 - Current Member of the IMM-Green Team IMM-Green team aims to help transform iMM into a positive example of environmental sustainability in research, medicine and workplace practices
Member
2019/04 - 2020/09 2019/2020 CAML PhD Worksop Committee
Member
 Universidade de Lisboa Faculdade de Medicina, Portugal
2019/04 - 2020/05 PhD Representative at Instituto de Medicina Molecular João Lobo Antunes
President / Vice-president
 Instituto de Medicina Molecular, Portugal
2018/04 - 2019/05 XIII CAML PhD Students' Meeting, 2019
Coordinator
 Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018 2017 CAML PhD Retreat Organizing Committee
Member
 Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Distinctions

Award

2023 Best oral presentation - III ASPIC-ASEICA International Meeting
Associação Portuguesa de Investigação em Cancro, Portugal

Asociación Española de Investigación sobre el Cáncer, Spain
2019 Best poster - XI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia
2017 Best First Year Oral Presentation - XI CAML PhD Students' Meeting
Instituto de Medicina Molecular, Portugal