Personal identification

Full name

Nelson Rebola

Citation names

• Rebola, Nelson

Author identifiers

Ciência ID

C81D-F49A-94CC

ORCID iD

0000-0002-9975-4747

Addresses

• ICM - Institut du Cerveau | Paris Brain Institute Sorbonne Université CNRS UMR 7225 – INSERM U1127 Groupe Hospitalier Pitié Salpêtrière 47 Boulevard de l'Hopital, 75013, Paris, Ile-de-France, France (Professional)

Websites

• https://therebolalab.org/ (Professional)

	Degree	Classification
2008 Concluded	Biologia (Doutoramento) Major in Especialidade: Biologia Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Physiological and Pathophysiological Role of Adenosine A2a Receptors in the Hippocampus" (THESIS/DISSERTATION)

Science

	Category Host institution	Employer
2017/01/01 - Current	Coordinating Researcher (Research)	Centre National de la Recherche Scientifique, France
	Institut du Cerveau, France
2012/11/01 - 2017/10/01	Principal Investigator (Research)	Centre National de la Recherche Scientifique, France
	Institut Pasteur, France
2010/11/01 - 2012/10/01	Principal Investigator (Research)	Centre National de la Recherche Scientifique, France
	Université de Bordeaux, France
2008/10/01 - 2010/10/01	Postdoc (Research)	Centre National de la Recherche Scientifique, France
	Université de Bordeaux, France

Contract

	Designation	Funders
2023/10/01 - 2027/09/30	Deciphering dendritic computations of GABAergic interneurons within neural circuits DendroGABA Principal investigator	Institut du Cerveau Ongoing
2022/01/01 - 2026/01/01	Decoding contextual information processing by cortical layer 1 microcircuits. DecoSensoL1 Principal investigator Institut du Cerveau, France	Agence nationale de la recherche Ongoing
2021/03/01 - 2025/02/28	Role and Cellular Physiology of New Excitatory Glycine Receptors in the Forebrain – EXCIGLY Excigly Principal investigator Institut du Cerveau, France	Agence nationale de la recherche Ongoing
2016/12/01 - 2021/11/30	Impact of NMDA receptor diversity in sensory information processing 678250 Principal investigator Institut du Cerveau, France	European Research Council

Publications

Journal article

Koukouli F; Montmerle M; Aguirre A; De Brito Van Velze M; Peixoto J; Choudhary V; Varilh M; et al. "Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons.". Cell reports (2022): https://europepmc.org/articles/PMC9433882. 10.1016/j.celrep.2022.111202 Bossi S; Dhanasobhon D; Ellis-Davies GCR; Frontera J; de Brito Van Velze M; Lourenço J; Murillo A; et al. "GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits.". Neuron (2022): https://europepmc.org/articles/PMC9365314. 10.1016/j.neuron.2022.05.016 Morabito A; yann zerlaut; Serraz B; Romain SALA; Pierre Paoletti; Rebola N. "Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons.". Cell reports (2022): https://europepmc.org/articles/PMC8889438. 10.1016/j.celrep.2022.110415 Andrés de la Rocha-Muñoz; Núñez E; Vishwanath AA; Sergio Gómez López; Dhanasobhon D; Rebola N; López-Corcuera B; Jaime de Juan-Sanz; Aragón C. "The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.". Communications biology (2021): https://europepmc.org/articles/PMC8523746. 10.1038/s42003-021-02718-6 Rebola N; Reva M; Kirizs T; Szoboszlay M; Lorincz A; Moneron G; Nusser Z; DiGregorio DA. "Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function.". Neuron (2021): http://europepmc.org/abstract/med/34619089. 10.1016/j.neuron.2021.08.037 Rebola N; Reva M; Kirizs T; Szoboszlay M; Lorincz A; Moneron G; Nusser Z; DiGregorio DA. "Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function.". Neuron (2019): http://europepmc.org/abstract/med/31558350. 10.1016/j.neuron.2019.08.014 Marvin JS; Scholl B; Wilson DE; Podgorski K; Kazemipour A; Müller JA; Schoch S; et al. "Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.". Nature methods (2018): http://europepmc.org/abstract/med/30377363. 10.1038/s41592-018-0171-3 Carta M; Srikumar BN; Gorlewicz A; Rebola N; Mulle C. "Activity-dependent control of NMDA receptor subunit composition at hippocampal mossy fibre synapses.". The Journal of physiology (2018): http://europepmc.org/abstract/med/29218821. 10.1113/jp275226 Agís-Balboa RC; Pinheiro PS; Rebola N; Kerimoglu C; Benito E; Gertig M; Bahari-Javan S; et al. "Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.". The EMBO journal (2017): http://europepmc.org/abstract/med/28768717. 10.15252/embj.201796821 Rebola N; Carta M; Mulle C. "Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding.". Nature reviews. Neuroscience (2017): http://europepmc.org/abstract/med/28251990. 10.1038/nrn.2017.10 Newton A; Seidenstein A; McDougal R; Pérez-Cervera A; Huguet G; M-Seara T; Haimerl C; et al. "26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3". BMC neuroscience (2017): http://europepmc.org/abstract/PMC/PMC5592441. Laprell L; Repak E; Franckevicius V; Hartrampf F; Terhag J; Hollmann M; Sumser M; et al. "Optical control of NMDA receptors with a diffusible photoswitch.". Nature communications (2015): http://europepmc.org/abstract/med/26311290. 10.1038/ncomms9076 Lourenço J; Pacioni S; Rebola N; van Woerden GM; Marinelli S; DiGregorio D; Bacci A. "Non-associative potentiation of perisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons.". PLoS biology (2014): http://europepmc.org/abstract/med/25003184. 10.1371/journal.pbio.1001903 Vergnano AM; Rebola N; Savtchenko LP; Pinheiro PS; Casado M; Kieffer BL; Rusakov DA; Mulle C; Paoletti P. "Zinc dynamics and action at excitatory synapses.". Neuron (2014): http://europepmc.org/abstract/med/24908489. 10.1016/j.neuron.2014.04.034 Carta M; Lanore F; Rebola N; Szabo Z; Da Silva SV; Lourenço J; Verraes A; et al. "Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.". Neuron (2014): http://europepmc.org/abstract/med/24486086. 10.1016/j.neuron.2013.12.028 Rebola N; Carta M; Lanore F; Blanchet C; Mulle C. "NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.". Nature neuroscience (2011): http://europepmc.org/abstract/med/21532578. 10.1038/nn.2809 Rebola N; Simões AP; Canas PM; Tomé AR; Andrade GM; Barry CE; Agostinho PM; Lynch MA; Cunha RA. "Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.". Journal of neurochemistry (2011): http://europepmc.org/abstract/med/21235574. 10.1111/j.1471-4159.2011.07178.x Thorsen TS; Madsen KL; Rebola N; Rathje M; Anggono V; Bach A; Moreira IS; et al. "Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.". Proceedings of the National Academy of Sciences of the United States of America (2009): http://europepmc.org/abstract/med/20018661. 10.1073/pnas.0902225107 Rebola N; Srikumar BN; Mulle C. "Activity-dependent synaptic plasticity of NMDA receptors.". The Journal of physiology (2009): http://europepmc.org/abstract/med/19822542. 10.1113/jphysiol.2009.179382 Lanore F; Rebola N; Carta M. "Spike-timing-dependent plasticity induces presynaptic changes at immature hippocampal mossy fiber synapses.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2009): http://europepmc.org/abstract/med/19571120. 10.1523/jneurosci.1997-09.2009 Yu L; Shen HY; Coelho JE; Araújo IM; Huang QY; Day YJ; Rebola N; et al. "Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.". Annals of neurology (2008): http://europepmc.org/abstract/med/18300283. 10.1002/ana.21313 Shen HY; Coelho JE; Ohtsuka N; Canas PM; Day YJ; Huang QY; Rebola N; et al. "A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2008): http://europepmc.org/abstract/med/18354001. 10.1523/jneurosci.5255-07.2008 Rebola N; Lujan R; Cunha RA; Mulle C. "Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.". Neuron (2008): http://europepmc.org/abstract/med/18184569. 10.1016/j.neuron.2007.11.023 Köfalvi A; Pereira MF; Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA. "Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus.". British journal of pharmacology (2007): http://europepmc.org/abstract/med/17435795. 10.1038/sj.bjp.0707252 Rebola N; Sachidhanandam S; Perrais D; Cunha RA; Mulle C. "Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2007): http://europepmc.org/abstract/med/17428973. 10.1523/jneurosci.5182-06.2007 Karovic O; Tonazzini I; Rebola N; Edström E; Lövdahl C; Fredholm BB; Daré E. "Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.". Biochemical pharmacology (2006): http://europepmc.org/abstract/med/17169330. 10.1016/j.bcp.2006.11.008 Degroot A; Köfalvi A; Wade MR; Davis RJ; Rodrigues RJ; Rebola N; Cunha RA; Nomikos GG. "CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.". Molecular pharmacology (2006): http://europepmc.org/abstract/med/16855179. 10.1124/mol.106.024661 Pereira DB; Rebola N; Rodrigues RJ; Cunha RA; Carvalho AP; Duarte CB. "Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus.". Journal of neuroscience research (2006): http://europepmc.org/abstract/med/16477614. 10.1002/jnr.20784 Ciruela F; Casadó V; Rodrigues RJ; Luján R; Burgueño J; Canals M; Borycz J; et al. "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2006): http://europepmc.org/abstract/med/16481441. 10.1523/jneurosci.3574-05.2006 Coelho JE; Rebola N; Fragata I; Ribeiro JA; de Mendonça A; Cunha RA. "Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus.". Neuroscience (2006): http://europepmc.org/abstract/med/16442739. 10.1016/j.neuroscience.2005.12.012 Tebano MT; Martire A; Rebola N; Pepponi R; Domenici MR; Grò MC; Schwarzschild MA; et al. "Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects.". Journal of neurochemistry (2005): http://europepmc.org/abstract/med/16271052. 10.1111/j.1471-4159.2005.03455.x Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA. "Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.". Neurochemistry international (2005): http://europepmc.org/abstract/med/16011860. 10.1016/j.neuint.2005.05.009 Pinheiro PS; Rodrigues RJ; Rebola N; Xapelli S; Oliveira CR; Malva JO. "Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses.". Neurochemistry international (2005): http://europepmc.org/abstract/med/16005547. 10.1016/j.neuint.2005.05.007 Rodrigues RJ; Alfaro TM; Rebola N; Oliveira CR; Cunha RA. "Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.". Journal of neurochemistry (2005): http://europepmc.org/abstract/med/15659214. 10.1111/j.1471-4159.2004.02887.x Rebola N; Rodrigues RJ; Lopes LV; Richardson PJ; Oliveira CR; Cunha RA. "Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.". Neuroscience (2005): http://europepmc.org/abstract/med/15893632. 10.1016/j.neuroscience.2005.01.054 Rebola N; Canas PM; Oliveira CR; Cunha RA. "Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.". Neuroscience (2005): http://europepmc.org/abstract/med/15857695. 10.1016/j.neuroscience.2005.01.014 Rebola N; Porciúncula LO; Lopes LV; Oliveira CR; Soares-da-Silva P; Cunha RA. "Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.". Epilepsia (2005): http://europepmc.org/abstract/med/15987272. 10.1111/j.1528-1167.2005.01026.x Lopes LV; Halldner L; Rebola N; Johansson B; Ledent C; Chen JF; Fredholm BB; Cunha RA. "Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.". British journal of pharmacology (2004): http://europepmc.org/abstract/med/14993095. 10.1038/sj.bjp.0705692 Rebola N; Pinheiro PC; Oliveira CR; Malva JO; Cunha RA. "Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus.". Brain research (2003): http://europepmc.org/abstract/med/14499945. 10.1016/s0006-8993(03)03247-5 Rebola N; Sebastião AM; de Mendonca A; Oliveira CR; Ribeiro JA; Cunha RA. "Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.". Journal of neurophysiology (2003): http://europepmc.org/abstract/med/12904509. 10.1152/jn.00896.2002 Lopes LV; Rebola N; Pinheiro PC; Richardson PJ; Oliveira CR; Cunha RA. "Adenosine A3 receptors are located in neurons of the rat hippocampus.". Neuroreport (2003): http://europepmc.org/abstract/med/14502093. 10.1097/00001756-200308260-00021 Rebola N; Coelho JE; Costenla AR; Lopes LV; Parada A; Oliveira CR; Soares-da-Silva P; de Mendonça A; Cunha RA. "Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats.". The European journal of neuroscience (2003): http://europepmc.org/abstract/med/12925008. 10.1046/j.1460-9568.2003.02815.x Rebola N; Oliveira CR; Cunha RA. "Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus.". European journal of pharmacology (2002): http://europepmc.org/abstract/med/12409002. 10.1016/s0014-2999(02)02475-5