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I am graduated in Biochemistry (MSc), from the University of Beira Interior, in 2008. In 2010, I moved to the Netherlands to the group of Dr. Tom van der Pol, at the Center for Experimental and Molecular Medicine (Amsterdam Medical Center, AMC). During that period I acquired skills/knowledge in Infection, Immunity and Inflammation. In 2011, I started functions as a Research Technician in the group of Dr. Ronald Stam, at Pediatric Oncology/Hematology department, Erasmus Medical Center (Rotterdam, the Netherlands). There I participated and contributed for the successful completion of several projects, such as: i) Unravelling drug resistance in Infant Acute Lymphoblastic Leukaemia (ALL); ii) Role of Epigenetics in Infant ALL; iii) Role of Bone-Marrow niche in MLL-ALL using in vivo xenotransplantations models. In 2016, I moved together with the entire team of Dr. Stam to the Princess Maxima Center, Center for Pediatric Oncology (Utrecht, the Netherlands). During that time, while working as Senior Research Technician I was enrolled on the project: High-Throughput screening of Epigenetic-based drugs for the treatment of high risk Leukemias. As Research Assistant, I contributed directly to the different projects running in the team by planning and executing experiments, analysing and reporting data, working closely with PhD students and post-doctoral fellows. In 2018, I joined the team of Dr. Hugo Fernandes and Dr. Lino Ferreira, group of Biomaterials and Stem Cell-based Therapies, at the Biocant/CNC (Cantanhede, Portugal). My current research focuses on the study of GLP-1 receptor expression and beta-cell mass in type 2 diabetes patients. In 2019, I was awarded with a PhD fellowship from FCT to study the Extracellular Vesicles in Diabetes. My research achievements has been published in international peer-reviewed journal, such as Leukemia, Haematologica, Oncotarget, European Journal of Cancer, Immunobiology, the Journal of Biological Chemistry and Clinical Biochemistry.
Identification

Personal identification

Full name
Sandra Sofia Mimoso Pinhanços

Citation names

  • Pinhanços, SS or Pinhanços, SM

Author identifiers

Ciência ID
C814-42E1-86D8
ORCID iD
0000-0002-6748-5554
Google Scholar ID
tv40oQUAAAAJ

Email addresses

  • sandra.sofia.m@gmail.com (Professional)
  • sandra.sofia.m@uc-biotech.pt (Professional)
  • spinhancos@cnc.uc.pt (Professional)

Telephones

Mobile phone
  • 934121400 (Personal)
Telephone
  • 231249170 (Professional)
  • 231407377 (Personal)

Addresses

  • UC-Biotech, Nucleo 4, Lote8, 3061-197 , Cantanhede, Cantanhede, Portugal (Professional)
  • Avenida do Brasil, lote 8, 3F, 3060-125, Cantanhede, Cantanhede, Portugal (Personal)

Websites

  • https://www.researchgate.net/profile/Sandra_Sofia_Mimoso_Pinhancos2 (Social media)
  • www.linkedin.com/in/sandra-sofia-mimoso-pinhancos-073542149 (Professional)
  • http://erachair.uc-biotech.pt/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Engineering and Technology - Other Engineering and Technologies

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Dutch Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020/03/01 - 2024/03/01
Ongoing
PhD Program in Experimental Biology and Biomedicine (Doutoramento)
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
"Extracellular vesicles in Diabetes" (THESIS/DISSERTATION)
2020/02/17 - 2020/02/21
Concluded
Communication in Science (Outros)
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2018/05 - 2018/05
Concluded
Programming in R (basic Course) (Graduado)
Erasmus MC, Netherlands
2017 - 2017
Concluded
Indesign CS6 (Graduado)
Erasmus MC, Netherlands
2016/06/23 - 2016/06/24
Concluded
Survival Analysis Course (from basic statistics to Kaplan-Meier plots) (Graduado)
Erasmus MC, Netherlands
2016/04/05 - 2016/04/05
Concluded
Photoshop & Illustrator CS5 workshop (Graduado)
Erasmus MC, Netherlands
2015/11/02 - 2015/11/06
Concluded
Course Biomedical Research Techniques ((primers and probes, methylation, siRNA, Flow Cytometry, Microscopy) (Graduado)
Major in Research Techniques
Erasmus MC, Netherlands
2014/06/10 - 2014/06/12
Concluded
Workshop Molecular Aspects of Hematological Malignancies (Graduado)
Erasmus MC, Netherlands
2013/09/24 - 2013/09/27
Concluded
Translational Animal Imaging (3D Fluorescence and Bioluminescence (IVIS), Fluorescence Molecular Tomography (FMT), µCT) (Graduado)
Erasmus MC, Netherlands
2013/04/08 - 2013/04/26
Concluded
Course Animal Experimentation Article 9 (FELASA C) (Graduado)
Major in Experimentação Animal
Erasmus MC, Netherlands
2007/09 - 2008/09
Concluded
Bioquímica (Mestrado)
Major in Bioquímica
Universidade da Beira Interior, Portugal
"Human Bocavirus infection in children with Respiratory tract Infection" (THESIS/DISSERTATION)
17
2002/09 - 2007/09
Concluded
Bioquímica (Licenciatura)
Major in Bioquímica
Universidade da Beira Interior, Portugal
"Role between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase gene, in association to Alzheimer's type dementia " (THESIS/DISSERTATION)
14
Affiliation

Science

Category
Host institution
Employer
2020/03/01 - Current Researcher (Research) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Biocant Associação de Transferência de Tecnologia, Portugal
2018/10 - 2020/02/28 Research Assistant (Research) Biocant Associação de Transferência de Tecnologia, Portugal
2016/09 - 2018/09 Research Assistant (Research) Princess Maxima Center, Center for Pediatric Oncology, Netherlands
2011/01/14 - 2016/09 Research Assistant (Research) Erasmus MC Afdeling Kindergeneeskunde, Netherlands
2010/02 - 2010/12 Research Trainee (Research) Amsterdam Universitair Medische Centra, Netherlands

Others

Category
Host institution
Employer
2008/03 - 2010/01 Assistente de Farmácia Farmácia Central Sabugal, Guarda, Portugal
2007/10 - 2008/02 Assistente de Farmácia Farmácia Mousaco Torrão, Portugal
Projects

Grant

Designation Funders
2020 - Current Extracellular Vesicles in Diabetes
SFRH/BD/144119/2019
PhD Student Fellow
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018 - Current Towards personalized beta-cell mass imaging in type 2 Diabetes
95105008
Technical development
Biocant Associação de Transferência de Tecnologia, Portugal
ZonMw
Ongoing

Other

Designation Funders
2016 - 2018 High Throughput of epigenetic drug screening in high risk leukemias
-
Technical development
Princess Maxima Center, Center for Pediatric Oncology, Netherlands
Stichting Kinderen Kankervrij (KiKa)
Concluded
2012 - 2016 Role of Bone Marrow niche Microenvironment in MLL-rearranged ALL using in vivo xenotransplantations models
KIKA.Project89
Technical development
Erasmus MC, Netherlands
Stichting Kinderen Kankervrij (KiKa)
Concluded
2012 - 2016 Role of epigenetics in MLL rearranged infant ALL
-
Technical development
Erasmus MC, Netherlands
Concluded
2011 - 2011/12 Unraveling drug resistance in Acute Lymphoblastic Leukemia in Infants
-
Technical development
Erasmus MC, Netherlands
Stichting Kinderen Kankervrij (KiKa)
Concluded
2010 - 2010 Impact of p38 mitogen activated protein kinase inhibitor in pulmonary inflammation
-
Other
Amsterdam Medical Center, Netherlands
2010 - 2010 The potency of AMPK activation by AICAR to reduce inflammation in vitro and in vivo in a model of LTA-induced lung injury
-
Other
Amsterdam Medical Center, Netherlands
Concluded
2007 - 2008 Detection of Human Bocavirus in children with Respiratory Infection
Master project
Other
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2006 - 2007 Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia
Projecto de Licenciatura
Other
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Concluded
Outputs

Publications

Conference poster
  1. Pinhanços, SS or Pinhanços, SM. "Selective Inhibition of Class II HDAC Isoforms 4 and 5 Provides a Promising Therapeutic Intervention for MLL-Rearranged Acute Lymphoblastic Leukemia in Infants". 2021.
    10.1182/blood-2021-147164
Journal article
  1. Priscilla Wander; Susan T. C. J. M. Arentsen-Peters; Kirsten S. Vrenken; Sandra Mimoso Pinhan¿os; Bianca Koopmans; M. Emmy M. Dolman; Luke Jones; et al. "High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling". Biomedicines 10 3 (2022): 638-638. https://doi.org/10.3390/biomedicines10030638.
    10.3390/biomedicines10030638
  2. Mark Kerstjens; Patricia Garrido Castro; Sandra S. Pinhanços; Pauline Schneider; Priscilla Wander; Rob Pieters; Ronald W. Stam. "Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia". Biomedicines (2021): https://doi.org/10.3390/biomedicines9070711.
    10.3390/biomedicines9070711
  3. Priscilla Wander; Susan T.C.J.M. Arentsen-Peters; Sandra S. Pinhan¿os; Bianca Koopmans; M.Emmy M. Dolman; Rijndert Ariese; Frank L. Bos; et al. "High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia". Translational Oncology (2021): https://doi.org/10.1016/j.tranon.2021.101048.
    10.1016/j.tranon.2021.101048
  4. Pinhanços, SS or Pinhanços, SM. "Decitabine mildly attenuates MLL -rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo-sensitizer". eJHaem (2020): http://dx.doi.org/10.1002/jha2.81.
    10.1002/jha2.81
  5. Pinhanços, SS or Pinhanços, SM. "Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia". Leukemia (2020): http://dx.doi.org/10.1038/s41375-020-0895-9.
    10.1038/s41375-020-0895-9
  6. Garrido Castro P; van Roon EHJ; Pinhanços SS; Trentin L; Schneider P; Kerstjens M; Te Kronnie G; et al. "The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.". Leukemia (2018): http://europepmc.org/abstract/med/28690313.
    10.1038/leu.2017.216
  7. Kerstjens M; Pinhancos SS; Garrido Castro P; Schneider P; Wander P; Pieters R; Stam RW. "Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo.". Haematologica (2018): http://europepmc.org/abstract/med/29419436.
    10.3324/haematol.2017.174060
  8. Kerstjens M; Driessen EM; Willekes M; Pinhanços SS; Schneider P; Pieters R; Stam RW. "MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations.". Oncotarget (2017): http://europepmc.org/abstract/med/27588400.
    10.18632/oncotarget.11730
  9. Driessen EM; Pinhanços SS; Schneider P; de Lorenzo P; Valsecchi MG; Pieters R; Stam RW. "Versican expression is an adverse prognostic factor in MLL-rearranged infant acute lymphoblastic leukaemia.". European journal of cancer (Oxford, England : 1990) (2016): http://europepmc.org/abstract/med/26901613.
    10.1016/j.ejca.2015.12.031
  10. Spijkers-Hagelstein JA; Schneider P; Pinhanços SM; Garrido Castro P; Pieters R; Stam RW. "Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.". European journal of cancer (Oxford, England : 1990) (2014): http://europepmc.org/abstract/med/24703900.
    10.1016/j.ejca.2014.03.011
  11. Spijkers-Hagelstein JA; Pinhanços SS; Schneider P; Pieters R; Stam RW. "Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.". Leukemia (2014): http://europepmc.org/abstract/med/23958920.
    10.1038/leu.2013.245
  12. Hoogendijk AJ; Pinhanços SS; van der Poll T; Wieland CW. "Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation.". Immunobiology (2013): http://europepmc.org/abstract/med/22727776.
    10.1016/j.imbio.2012.05.027
  13. Spijkers-Hagelstein JA; Mimoso Pinhanços S; Schneider P; Pieters R; Stam RW. "Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.". Leukemia (2013): http://europepmc.org/abstract/med/23334362.
    10.1038/leu.2012.372
  14. Hoogendijk AJ; Pinhanços SS; van der Poll T; Wieland CW. "AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-ß-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation.". The Journal of biological chemistry (2013): http://europepmc.org/abstract/med/23322781.
    10.1074/jbc.m112.413138
  15. Cascalheira JF; João SS; Pinhanços SS; Castro R; Palmeira M; Almeida S; Faria MC; Domingues FC. "Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia.". Clinical biochemistry (2009): http://europepmc.org/abstract/med/19232336.
    10.1016/j.clinbiochem.2009.02.006
Thesis / Dissertation
  1. Domingues, Fernanda da Conceição; Almeida, Sofia Isabel de Aguiar de; Pinhanços, Sandra Sofia Mimoso. "Detecção do bocavírus humano em crianças com infecção respiratória". Master, 2008. http://hdl.handle.net/10400.6/2492.

Other

Other output
  1. Serum homocysteine. Objectives: To study the interplay between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, in association to Alzheimer's type dementia (ATD). Design and methods: Case-control study including 19 individuals diagnosed with ATD and 36 healthy controls. Serum concentrations of the analytes were determined and. 2009. Cascalheira, Jose F.; Joao, Sara S.; Pinhancos, Sandra S.; Castro, Rita; Palmeira, Manuela; Almeida, Sofia; Faria, Maria C.; Domingues, Fernanda C.. http://hdl.handle.net/10451/21475.
    http://dx.doi.org/10.1016/j.clinbiochem.2009.02.006
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/03/11 miRNAs e Vesículas Extracelulares: uma nova terapia no tratamento do síndrome metabólico 18º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/03/01 - 2019/06/01 GLP1-R in Type 2 Diabetes
Co-supervisor
mestrado em Biotecnologia Farmacêutica na Faculdade de Farmácia da Universidade de Coimbra (Master)
Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2020/09/19 - Current 2nd Retreat of CIBB's Innovative Therapies Area. zoom meeting 19/09/2020
Conference
2nd Retreat of CIBB's Innovative Therapies Area.
2022/09/21 - 2022/09/21 Medical Writing na comunicação para o doente
2021/11/16 - 2021/11/16 Formação - Primeiros Socorros
Other
Formação - Primeiros Socorros
Centro de Neurociências e Biologia Celular, Portugal
2021/07/14 - 2021/07/14 Training in Health and Safety at Work "SST-Prevenção da Transmissão da Infeção"
Seminar
"SST-Prevenção da Transmissão da Infeção"
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/06/11 - 2021/06/11 1st RESETaging Conference, June 11th, 2021
Conference
1st RESETaging Conference
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/04/19 - 2021/04/23 PDBEB Courses 2020/2021 - Advanced Therapies
Other
Advanced Therapies
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/02/01 - 2021/02/05 PDBEB Courses 2020/2021 - High-Throughput Screening for Target and Drug Discovery
Other
High-Throughput Screening for Target and Drug Discovery
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2020/12/18 - 2020/12/18 First Workshop of the Portuguese Network on Extracellular Vesicles: EVs in Health and Disease Online Even
Conference
First Workshop of the Portuguese Network on Extracellular Vesicles: EVs in Health and Disease
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/11/18 - 2020/11/18 1st Retreat Metabolism Aging and Disease area
Other
1st Retreat Metabolism Aging and Disease area
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2020/09/20 - 2020/09/30 ESCI Virtual Meeting 2020
Conference
ESCI Virtual Meeting 2020
2019/06/28 - 2019/06/29 “Ageing: Models, mechanisms and therapies” conference.
Conference
“Ageing: Models, mechanisms and therapies”
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2017/06/22 - 2017/06/25 22nd Congress of European Hematology Association (EHA), Madrid, Spain.
Congress
Congress of European Hematology Association

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/07/11 - 2022/07/18 "Curso Avançado: Regulatory Affairs & Patents" "Curso Avançado: Regulatory Affairs & Patents" Universidade de Coimbra, Portugal
2022/06/29 - 2022/06/29 "Desenho de ensaios clínicos: Conceitos fundamentais" "Desenho de ensaios clínicos: Conceitos fundamentais"