???global.info.a_carregar???
Gisselle Pérez Machado. Chief of Technical Department EpiDisease & Quality Managment System (2017-up to the present). Majored with honors (5.2/5 pts) in Pharmaceutical Sciences (1990) at the Universidad Central de Las Villas (UCLV), Cuba. This BS degree was recognized in Spain in 2010. Master degrees, in Genetics (2001) from the Universidad Autónoma de Barcelona (UAB); and in Experimental Toxicology (2002) from the University of Havana. PhD in Genetics by UAB (excellent cum laude). Full Professor (highest academic category awarded by the Cuban Higher Education Ministry). Educational expertise in biology- and biomedical-related subjects in bachelor's courses in both UCLV, UAB and Universitat de Valencia (Spain) as well as in Master and Post-graduated programs. Research expertise related to the (i) Cancer Genetics, ii) Genetic Toxicology (iii) Regulatory in drug development iv) Chemo-Informatics by applying QSAR techniques to drug search/development; (V) Epigenetic and Genetic biomarkers and in vitro diagnostic device development. The research in these areas and the stays at Universities from Cuba, and Spain, have allowed the publication of 27 peer-reviewed articles (h-index=10), 3 book sections, and the participation in 33 scientific events. Has contributed to register 2 products with pharmaceutical activities in Cuba, winning five awards from both the Academy of Sciences of Cuba and of other international institutions. Enterprise Expertise/Achievments: Quality Managment System &, Data Protection Policy. AENOR certificate for the COVID diagnostic tests by RT-qPCR. Permission granted by the Heatlh Dept for Genetic and Epigenetic diagnosis.
Read full resume ↓
Identification

Personal identification

Full name
Gisselle Pérez Machado

Citation names

  • Pérez-Machado, G

Author identifiers

Ciência ID
C811-C045-2BFE
ORCID iD
0000-0003-0974-8907
Google Scholar ID
bV3aq6QAAAAJ
Researcher Id
AAX-7930-2020

Email addresses

  • giselle.perez@epidisease.com (Professional)

Addresses

  • Epidisease Parc Científic de la Universitat de València C/Catedràtic Agustín Escardino, 9 , 46980 , Paterna, Valencia, Spain (Professional)

Knowledge fields

  • Engineering and Technology - Environmental Biotechnology
  • Engineering and Technology - Medical Engineering - Medical Laboratory Technology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Public and Environmental Health
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Exact Sciences - Computer and Information Sciences
  • Natural sciences - Biological Sciences - Molecular Biology
  • Social Sciences - Economics and Business - Industrial Relations

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Portuguese Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1)
Catalan Upper intermediate (B2) Advanced (C1) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2003/10/09 - 2006/07/25
Concluded
 Genetica (Doutoramento)
Fundació Universitat Autónoma de Barcelona, Spain
"Genetic polymorphisms in thyroid cancer " (THESIS/DISSERTATION)
2001/10/03 - 2003/05/06
Concluded
 Genetica (Mestrado)
Universitat Autònoma de Barcelona, Spain
1999/11/05 - 2002/04/05
Concluded
 Toxicologia Experimental (Master Universitario)
Instituto de Farmacia y Alimentos , Universidad de La Habana, Spain
1985/09/03 - 1990/07/20
Concluded
 Pharmaceutical Sciences (Licenciatura)
Universidad Central Marta Abreu de las Villas, Cuba
"Study of triamcinolone acetonide in pediatric asthma patients " (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2017/04/17 - Current Contracted Researcher (Research) EpiDisease, Spain
2016/04/06 - 2017/05/02 Researcher (Research) Universitat de València, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2016/01/01 - 2016/04/01 Invited Full Professor (University Teacher) Universitat de València, Spain
2013/09/01 - 2015/07/24 Full Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2011/12 - 2013/08/31 Associate Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2011/09/05 - 2011/12/03 Invited Associate Professor (University Teacher) Universitat de València, Spain
2010/10/29 - 2011/09/04 Associate Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2010/05/07 - 2010/10/28 Invited Associate Professor (University Teacher) Universitat de València, Spain
2008/05 - 2010/05/06 Associate Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2006/09 - 2008/04 Assistant Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2001/11/01 - 2003/08 Assistant Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
2000/03/01 - 2000/06/01 Invited Assistant Professor (University Teacher) Universidade de Santiago de Compostela Facultade de Medicina e Odontoloxía, Spain
1999/05 - 2000/01/30 Assistant Professor (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba
1990/09 - 1999/04/27 Assistant (University Teacher) Universidad Central Marta Abreu de las Villas, Cuba

Others

Category
Host institution 		Employer
2017/05 - Current Responsible for Epigenetics-based IVD kits development and Quality Managment System EpiDisease, Spain
2003/09 - 2006/07 PhD student Universitat Autònoma de Barcelona, Spain
2000/09 - 2001/10 Master Student Universitat Autònoma de Barcelona, Spain
Projects

Grant

Designation Funders
2017/05 - 2021/06 Development of the ScoliPro Kit for the in-vitro diagnosis/prognosis of Scoliosis-related diseases
PTQ-15_07899
Researcher
EpiDisease, Spain
 Gobierno de España Ministerio de Economía y Empresa
Ongoing
2016/01/05 - 2016/04/30 Pathophysiology of diseases characterized by genomic instability
VLC-Bioclinic
Invited Scientist Fellow
Universitat de València, Spain
 Universitat de València
Concluded
2011/09/20 - 2013/10/04 Setting up a computational chemistry laboratory, for academic and scientific purposes, for the rational design of new drug candidates in diseases with a high social impact".
A1/036687/11
Integration into Research Grant Fellow
Concluded
2013/03/01 - 2013/08/01 Oxidative stress and antioxidant defense in the pathophysiology of progeroid diseases
VLC-Bioclinic/063935
Invited Scientist Fellow
Goethe Universität Frankfurt Lehrstuhl für Derivate und Financial Engineering, Germany

Universitat de València, Spain
Concluded
2009/05/04 - 2011/04/06 Strengthening academic and research capacity in the biopharmaceutical sciences for professionals involved in drug development
B/023658/09
Integration into Research Grant Fellow
Agencia Española de Cooperación Internacional para el Desarrollo, Spain
Concluded
2010/05 - 2011/04 Setting up a computational chemistry laboratory, for academic and scientific purposes, for the rational design of new drug candidates in diseases with a high social impact
AECID (D/031152/10).
Integration into Research Grant Fellow
Agencia Española de Cooperación Internacional para el Desarrollo
Concluded
2009/05 - 2011/04 Strengthening academic and research capacity in the biopharmaceutical sciences for professionals involved in drug development
B/023658/09
 N/A
2009/02/21 - 2010/03/05 Setting up a computational chemistry laboratory, for academic and scientific purposes, for the rational design of new drug candidates in diseases with a high social impact
AECID D/024153/09
Integration into Research Grant Fellow
Agencia Española de Cooperación Internacional para el Desarrollo
Concluded

Contract

Designation Funders
2020 - Current ScoliGenetics: Genetic polymorfisms for the diagnostic and progression of Adolescent Idiophatic Scoliosis.
PTQ2019-010552
Researcher
EpiDisease, Spain
Ongoing
2018 - 2021 Genetics and Epigenetics biomarkers for Antiaging therapies.
IMCBTA/2018/29
Researcher
EpiDisease, Spain
 CREATEC-CV
Ongoing
Outputs

Publications

Book chapter
  1. Pérez-Machado, G.. "Epigenetics in Medicine Precision". In Epigenetics in spine curvature disorders, edited by García-Giménez, J.L., 449-449. Amsterdam, Netherlands: Academic Press Elsevier, 2022.
    Published
  2. García-Giménez, José Luis; Beltrán-García, Jesús; Romá-Mateo, Carlos; Seco-Cervera, Marta; Pérez-Machado, Gisselle; Mena-Mollá, Salvador. "Epigenetic biomarkers for disease diagnosis". In Prognostic Epigenetics, 21-44. Elsevier, 2019.
    Published • 10.1016/b978-0-12-814259-2.00002-9
  3. Aguero-Chapin, Guillermin; Molina-Ruiz, Reinaldo; Pérez-Machado, Gisselle; Vasconcelos, Vitor; Rodríguez-Negrin, Zenaida; Antunes, Agostinho. "TI2BioP — Topological Indices to BioPolymers. A Graphical– Numerical Approach for Bioinformatics". In Recent Advances in Biopolymers, 254-277. InTech, 2016.
    Published • 10.5772/61887
  4. Agüero-Chapin, Guillermin; Pérez-Machado, Gisselle; Sánchez-Rodríguez, Aminael; Santos, Miguel Machado; Antunes, Agostinho. "Alignment-Free Methods for the Detection and Specificity Prediction of Adenylation Domains". In Nonribosomal Peptide and Polyketide Biosynthesis, edited by Bradley S, E, 253-272. New York, United States: Springer New York, 2016.
    Published • 10.1007/978-1-4939-3375-4_16
Conference paper
  1. Pérez-Machado, G; Agüero-Chapin, Guillermin; Antunes, Agostinho; Vasconselos, Vitor; de la Riva, Gustavo A. "The RNase III substrate specificity from that the E. coli’s to the Humans". Paper presented in MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition session NIXMSM-06, Bilbao, 2020.
    Published
Journal article
  1. Ibáñez-Cabellos, José Santiago; Seco-Cervera, Marta; Picher-Latorre, Carmen; Pérez-Machado, Gisselle; García-Giménez, José Luis; Pallardó, Federico V.. "Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867 12 (2020): 118845. http://dx.doi.org/10.1016/j.bbamcr.2020.118845.
    Published • 10.1016/j.bbamcr.2020.118845
  2. Pérez-Machado, G. "From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis". Bone (2020): http://dx.doi.org/10.1016/j.bone.2020.115563.
    10.1016/j.bone.2020.115563
  3. Agüero-Chapin, Guillermin; Galpert, Deborah; Molina-Ruiz, Reinaldo; Ancede-Gallardo, Evys; Pérez-Machado, Gisselle; De la Riva, Gustavo A.; Antunes, Agostinho. "Graph Theory-Based Sequence Descriptors as Remote Homology Predictors". Biomolecules 10 1 (2019): 26. http://dx.doi.org/10.3390/biom10010026.
    Open access • 10.3390/biom10010026
  4. Romá-Mateo, Carlos; Seco-Cervera, Marta; Ibáñez-Cabellos, José S.; Pérez, Giselle; Berenguer-Pascual, Ester; Rodríguez, Laura R.; García-Giménez, José L.. "Oxidative Stress and the Epigenetics of Cell Senescence: Insights from Progeroid Syndromes". Current Pharmaceutical Design 24 40 (2019): 4755-4770. http://dx.doi.org/10.2174/1381612824666190114164117.
    Published • 10.2174/1381612824666190114164117
  5. Ibáñez-Cabellos, José Santiago; Pérez-Machado, Giselle; Seco-Cervera, Marta; Berenguer-Pascual, Ester; García-Giménez, José Luis; Pallardó, Federico V.. "Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening". Redox Biology 14 (2018): 398-408. http://dx.doi.org/10.1016/j.redox.2017.10.004.
    Published • 10.1016/j.redox.2017.10.004
  6. Pérez-Machado, G; Cardona-Monzonís; A; Beltran Garcia; J; Ibañez Cabellos; J.S.; Kabir Malkani;; Mena Molla, S.; García-Giménez, J.L.. "Epigenetic biomarkers in cardiovascular disease. Journal of Laboratory and Precision Medicine.". Journal of Laboratory and Precision Medicine. 20 (2018): 3-24.
    Published
  7. García-Giménez, José Luis; Romá-Mateo, Carlos; Pérez-Machado, Gisselle; Peiró-Chova, Lorena; Pallardó, Federico V.. "Role of glutathione in the regulation of epigenetic mechanisms in disease". Free Radical Biology and Medicine 112 (2017): 36-48. http://dx.doi.org/10.1016/j.freeradbiomed.2017.07.008.
    Published • 10.1016/j.freeradbiomed.2017.07.008
  8. Agüero-Chapin, Guillermin; Pérez-Machado, Gisselle; Mull, Juan; Ancede-Gallardo, Evys; Antunes, Agostinho; Riva, Gustavo. "How the Protein Architecture of RNases III Influences their Substrate Specificity?". Current Pharmaceutical Design 22 33 (2016): 5065-5071. http://dx.doi.org/10.2174/1381612822666160511150416.
    Published • 10.2174/1381612822666160511150416
  9. Castillo-González, Daimel; Mergny, Jean-Louis; De Rache, Aurore; Pérez-Machado, Gisselle; Cabrera-Pérez, Miguel Angel; Nicolotti, Orazio; Introcaso, Antonellina; et al. "Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands". Journal of Chemical Information and Modeling 55 10 (2015): 2094-2110. http://dx.doi.org/10.1021/acs.jcim.5b00415.
    Published • 10.1021/acs.jcim.5b00415
  10. Ibañez-Cabellos, Jose Santiago; Perez-Machado, Giselle; Seco-Cervera, Marta; Garcia-Gimenez, Jose Luis; Pallardo, Federico V.. "Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita". Free Radical Biology and Medicine 75 (2014): S34. http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.771.
    Published • 10.1016/j.freeradbiomed.2014.10.771
  11. Seco-Cervera, Marta; Spis, Marta; Luis García-Giménez, José; Santiago Ibañez-Cabellos, José; Velázquez-Ledesma, Ana; Esmorís, Isabel; Bañuls, Sergio; Pérez-Machado, Giselle; V Pallardó, Federico. "Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes". Aging 6 3 (2014): 231-245. http://dx.doi.org/10.18632/aging.100649.
    Published • 10.18632/aging.100649
  12. Castillo-Gonzalez, Daimel; Perez-Machado, Gisselle; Pallardo, Federico; Garrigues-Pelufo, Teresa-Maria; Cabrera-Perez, Miguel-Angel. "Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity". Current Topics in Medicinal Chemistry 12 24 (2013): 2843-2856. http://dx.doi.org/10.2174/1568026611212240010.
    Published • 10.2174/1568026611212240010
  13. Castillo-Gonzalez, Daimel; Perez-Machado, Gisselle; Guedin, Aurore; Mergny, Jean-Louis; Cabrera-Perez, Miguel-Angel. "FDA-approved Drugs Selected Using Virtual Screening Bind Specifically to G-quadruplex DNA". Current Pharmaceutical Design 19 12 (2013): 2164-2173. http://dx.doi.org/10.2174/1381612811319120004.
    Published • 10.2174/1381612811319120004
  14. Ibáñez-Cabellos, J.S.; Seco-Cervera, M.; Pérez-Machado, G; García-Giménez, J.L.; Pallardó, F.V.. "Estudio del efecto del silenciamiento de genes implicados en la disqueratosis congénita sobre los sistemas antioxidantes celulares". Revista Española de Geriatría y Gerontología 48 (2013):
    Published
  15. Helguera, A.; Perez-Machado, G.; D.S. Cordeiro, M.; Borges, F.. "Discovery of MAO-B Inhibitors - Present Status and Future Directions Part I: Oxygen Heterocycles and Analogs". Mini-Reviews in Medicinal Chemistry 12 10 (2012): 907-919. http://dx.doi.org/10.2174/138955712802762301.
    Published • 10.2174/138955712802762301
  16. Pérez-Machado, G; Hernández, O. C.; Llanes, L.; Fernández, S.. "Derivados del 2-furiletileno inducen la muerte celular programada en células CHO". Electronic Journal of Biomedicine. 2 (2012): 27-37.
  17. García-Quispes, Wilser-Andrés; Pérez-Machado, Giselle; Sandoval, Berenice; Pastor, Susana; Velázquez, Antonia; Galofré, Pere; Biarnés, Josefina; Castell, Joan; Marcos, Ricard. "Are thyroid cancer patients sensitive to ionising radiation?". International Journal of Radiation Biology 87 9 (2011): 932-935. http://dx.doi.org/10.3109/09553002.2011.577507.
    Published • 10.3109/09553002.2011.577507
  18. Akdi, Abdelmounaim; Pérez, Gisselle; Pastor, Susana; Castell, Juan; Biarnés, Josefina; Marcos, Ricard; Velázquez, Antonia. "Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk". Thyroid 21 5 (2011): 519-525. http://dx.doi.org/10.1089/thy.2010.0384.
    10.1089/thy.2010.0384
  19. García-Quispes, Wilser-Andrés; Pérez-Machado, Giselle; Akdi, Abdelmounaim; Pastor, Susana; Galofré, Pere; Biarnés, Fina; Castell, Joan; Velázquez, Antonia; Marcos, Ricard. "Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 709-710 (2011): 67-72. http://dx.doi.org/10.1016/j.mrfmmm.2011.03.003.
    Published • 10.1016/j.mrfmmm.2011.03.003
  20. Agüero-Chapin, Guillermin; de la Riva, Gustavo A; Molina-Ruiz, Reinaldo; Sánchez-Rodríguez, Aminael; Pérez-Machado, Gisselle; Vasconcelos, Vítor; Antunes, Agostinho. "Non-linear models based on simple topological indices to identify RNase III protein members". Journal of Theoretical Biology 273 1 (2011): 167-178. http://dx.doi.org/10.1016/j.jtbi.2010.12.019.
    Published • 10.1016/j.jtbi.2010.12.019
  21. Pérez-Machado, G; Hernández, O.; Martínez, Y.; Barrueta, L.; Vazquez, N.; Fernández ,S.. "El número y posición de los átomos de bromo en compuestos derivados del 2-furiletileno afectan la citotoxicidad e inducen resistencia en células de mamíferos". Rev Electron Biomed / Electron J Biomed 3 (2011): 44-52.
  22. Agüero-Chapin, Guillermín; Pérez-Machado, Gisselle; Molina-Ruiz, Reinaldo; Pérez-Castillo, Yunierkis; Morales-Helguera, Aliuska; Vasconcelos, Vítor; Antunes, Agostinho. "TI2BioP: Topological Indices to BioPolymers. Its practical use to unravel cryptic bacteriocin-like domains". Amino Acids 40 2 (2010): 431-442. http://dx.doi.org/10.1007/s00726-010-0653-9.
    Published • 10.1007/s00726-010-0653-9
  23. Helguera, A.M.; Pérez-Machado, G.; Cordeiro, M.N.D.S.; Combes, R.D.. "Quantitative structure-activity relationship modelling of the carcinogenic risk of nitroso compounds using regression analysis and the TOPS-MODE approach". SAR and QSAR in Environmental Research 21 3-4 (2010): 277-304. http://dx.doi.org/10.1080/10629361003773930.
    Published • 10.1080/10629361003773930
  24. González Borroto, Jorge I.; Pérez Machado, Giselle; Creus, Amadeu; Marcos, Ricard. "Comparative genotoxic evaluation of 2-furylethylenes and 5-nitrofurans by using the comet assay in TK6 cells". Mutagenesis 20 3 (2005): 193-197. http://dx.doi.org/10.1093/mutage/gei026.
    Published • 10.1093/mutage/gei026
  25. González Borroto, Jorge I.; Pérez, Giselle; Creus, Amadeu; Marcos, Ricard. "Genotoxicity testing of the furylethylene derivative 1-(5-bromofur-2-yl)-2-bromo-2-nitroethene in cultured human lymphocytes". Food and Chemical Toxicology 42 2 (2004): 187-193. http://dx.doi.org/10.1016/j.fct.2003.08.012.
    Published • 10.1016/j.fct.2003.08.012
  26. Pérez-Machado, G; Gonzalez-Borroto, J.; Marco, Ricard; Creus, Amadeu. "In vitro genotoxicity testing of the furylethylene derivative UC 245 inhuman cells.". Mutagénesis 19 1 (2004): 75-80.
    Open access • Published
  27. Pérez-Machado, G; Cortes Rodríguez, R; Morales Montero, A; Tenorio Borroto, E; Marrero Chang, O; Aguila Jiménez, E. "Evaluación toxicológica del (1-(5-bromofur-2-il)-2 metil2-nitroeteno) en ratones.". Rev Cub Farm 8 20 (2004):
    Published
  28. Pérez-Machado, G; González J,. "Evaluación genotóxica del Bioplant mediante el ensayo de Micronúcleos en Sangre Periférica de ratón.". Acta Farmacéutica Bonaerense. 19 4 (2000): 281-284.
    Published
  29. Pérez-Machado, G; Sainz Suarez, O; Gonzalez-Borroto, J.. "Estandarización del ensayo de micronucleos trnasplacentarios utilizando sangre periférica de ratones neonatos.". OFIL 9 4 (1999): 20-22.
    Published
Report
  1. Pérez-Machado, G. 2001. Estandarización de tres técnicas de genotoxicidad y evaluación genotóxica del bioactivo G-1 y del BIOPLANT..

Other

Other output
  1. Certificate/Permission granted by the Health Dept. for Genetic Diagnosis and COVID test. Successful presentation of the technical file that authorized Epidisease as a genetic diagnostic center.. 2020. Pérez-Machado, G.
Spin-off company
  1. 2014. EpiDisease. Biotechnology.
Standard or policy
  1. ISO 9001:2015 Quality Managment System certification (COVID-19 diagnostic service). EpiDisease has successfully achieved the certification of the QMS under ISO Standard 9001:2015 for the provision of COVID-diagnostic services. The certification audit was passed without any minor or major Non Conformities or Observations.. 2021. Pérez-Machado, G.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Diagnosticando el Síndrome de Mowat Wilson en las Consultas de Dismorfología.
Supervisor
 Rare Diseases (Master)
Universitat de València, Spain
2020 - Current Mogamolizumab en Micosis Fungoide
Supervisor
 Rare Disease (Master)
Universitat de València, Spain
2020 - Current Diagnóstico de Porfiria Aguda Intermitente sin Diagnóstico Genético
Supervisor
 Rare Diseases (Master)
Universitat de València, Spain
2017/05/06 - Current In vitro diagnostic kits based on epigenetic biomarkers for the diagnosis and prognosis of orthopedic diseases
Supervisor
 Biomedicina (PhD)
Universitat de València, Spain
2019 - 2020 Micosis Fungoide y Síndrome de Sésary: Uso de Anticuerpos Monoclonales y Medicamentos Huerfános.
Supervisor
 Rare Diseases (Master)
Universitat de València, Spain
2013/10 - 2018/06 Deregulation of the redox state in models of acute depletion of genes involved in congenital dyskeratosis.
Supervisor
 Fisiologia (PhD)
Universitat de València, Spain
2016/02/04 - 2017/07/07 Nucleolus as an Oxidative Stress Sensor. Implications in Progeroid Pathologies
Supervisor
 BIOMEDICAL BIOTECHNOLOGY (Master)
Universitat Politècnica de València, Spain
2013/11/04 - 2015/07/20 Cytogenetic biomonitoring of workers in a pharmaceutical industry using the peripheral blood micronucleus test.
Supervisor
 Biology (Master)
Universidad Central Marta Abreu de las Villas, Cuba
2014 - 2014/06/25 Estudios ecotoxicológicos en diferentes bioindicadores ambientales del bioplaguicida Tricosave-34
Co-supervisor
 Biology (Degree)
Universidad Central Marta Abreu de las Villas, Cuba
2008 - 2013/11 Nouveaux ligands de quadruplexes. Approches in silico et in vitro.
Co-supervisor
 Biochemistry (PhD)
UNIVERSITE´S BORDEAUX I ET BORDEAUX SEGALEN, France
2009/04 - 2011/06 In vivo toxicity evaluation of the derivatives 2 furilethylenes G1 and UC 245 in rodents models
Supervisor
 Master en Toxicologia (Master)
Universidad Central Marta Abreu de las Villas, Cuba
2009/09 - 2010/07 Development and Application of the TI2BioP methodology to the identification of bacteriocine-type proteins.
Supervisor
 Biochemistry (Master)
Instituto Superior de Ciencias Médicas de Villa Clara Dr Serafín Ruíz Facultad de Estomatologia de Villa Clara, Cuba
2007/01/06 - 2008/07/17 Cytotoxicity of the derivatives 2 furilethylenes G1 and UC 245 in several mammalian cell lines
Supervisor
 Pharmacy (Master)
Universidad Central Marta Abreu de las Villas, Cuba

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/03/04 - Current V Update in Pediatric Spine Pathology. IDIOPATHIC SCOLIOSIS. STATE OF THE ART. PRINCIPLES. IDIOPATHIC SCOLIOSIS, TIPS AND TRICKS. CLINICAL CASES
Workshop
 IV Jornada de Actualización en Patología Raquídea Pediátrica, Un Fallo en un Plan es un Plan que Falla
2019/10/17 - 2019/10/18 New collection of Adolescent Idiopathic Scoliosis in the framework of the collaboration between CIBERER Biobank and EpiDisease S.L. Gisselle Pérez Machado; Eva García López; Salva Mena Molla; Paloma Bas Hermida; Pedro Rubio Belmar; Jose Luis Garcia Gimenez; Federico Pallardo Calatayud; Teresa Bas Hermida.
Conference
 X Congress of Spanish Biobanks
Spanish Biobank Network, Spain
2019/10/16 - 2019/10/18 Development of an epigenetic IVD test for the diagnosis and prognosis of Adolescent Idiopathic Scoliosis. Ester Berenguer Pascual, Gisselle Pérez Machado; Eva García López; Salva Mena Molla; Paloma Bas Hermida; Pedro Rubio Belmar; Jose Luis Garcia Gimenez; Federico Pallardo Calatayud; Teresa Bas Hermida.
Congress
 EUROSPINE 2019
EUROSPINE The Spine Society of Europe, Switzerland
2019/06/23 - 2019/06/26 EpiDisease: ScoliPro Novel prognostic tool for adolescent Idiopathic Scoliosis (AIS). Jose Luis Garcia Gimenez; Salva Mena Molla, Gisselle Pérez Machado; Eva García López; Ester Berenguer Pascual Eureka International Innovation & Entrepreneurship Competition
Eureka International Group (EIG), Australia
2019/03/12 - 2019/03/14 CIBER and EpiDisease S.L., 5 years of public-private partnership. Ester Berenguer Pascual; Gisselle Pérez Machado; Dayme Gonzalez Rodriguez; Eva García López; Salva Mena Mollá; Jesus García Beltrán; Rebeca Osca Verdegal; Carmen Aguado Muñoz; Salva Martí Pérez; Laura García Piqueres; Federico Pallardó Calatayud; Jose Luis García Giménez.
Meeting
 XII CIBERER Annual Meeting
Centro de Investigaciones Biomédicas en Red, Spain
2019/03/12 - 2019/03/14 Management models for biological samples of human origin and their associated data. Carmen Aguado Muñoz; Salva Martí Pérez; Ester Berenguer Pascual; Gisselle Pérez Machado; Jose Maria Millan Salvador; Federico Pallardó Calatayud.
Meeting
 XII CIBERER Annual Meeting
Centro de Investigación Biomédica en Red, Spain
2018/05/24 - 2018/05/26 Epigenetic. New strategies for skin care and health.
Congress
 VIII Congreso Anual de farmacéuticos comunitarios. I Reunión Internacional de Farmacéuticos Comunitarios
Sociedad Española de Farmacéuticos Comunitarios (SEFAC), Spain
2017/03/24 - 2017/03/27 EpiDisease: Innovation in in-vitro diagnostics based on epigenetics. Jose Luis Garcia Gimenez; Salvador Mena Molla; Lorena Peiro Chova; Jose Santiago Ibañez , Marta Seco Cervera; Carlos Roma Mateo; Eva Garcia LOpez; Dayme Gonzalez Rodriguez; Pablo Soro Barrio; Jesus García Beltran; Gisselle Pérez Machado; Federico Pallardo Calatayud.
Meeting
 X Reunión Anual CIBERER.
Centro de Investigaciones Biomédicas en Red, Spain
2017/03/23 - 2017/03/24 Acute depletion of DKC1 and NOP10 produces oxidative stress. Jose Santiago Ibañez Cabellos; Gisselle Pérez Machado; Jose Luis Garcia Gimenez; Marta Seco Cervera; Ester Berenguer Pascual; Dayme Gonzalez Rodriguez; Pablo Soro Barrio; Jesus García Beltran; Lorena Peiro Chova; Federico Pallardo Calatayud.
Meeting
 X Reunión Anual CIBERER.
Centro de Investigaciones Biomédicas en Red, Spain
2016/06/07 - 2016/06/10 Topological Indices to Biopolymers and sequence vectorization phylogenetic analysis. Graphical Numerical tools for biomolecules encoding. R Molina, E Ancede, G Agüero, G Perez, A Antunes
Symposium
 International Symposium of chemistry
Sociedad Cubana de Química, Cuba
2016/03/07 - 2016/03/08 Molecular characterization of cellular models associated with congenital dyskeratosis genotypes. Jose Santiago Ibañez Cabellos; Jose Luis García Giménez; Gisselle Perez Machado; Marta Seco Cervera; Esther Berenguer Pascual; Federico Pallardo Calatayud.
Meeting
 IX Reunión Anual CIBERER
Centro de Investigaciones Biomédicas en Red, Spain
2015/06/26 - 2015/06/30 Alignment-free methods for the detection and specificity prediction of Adenylation domains. Agostinho Antunes, Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Aminael Sánchez-Rodríguez and Miguel Santos.
Meeting
 Evolution 2015
American Society of Naturalists, United States
2015/06/24 - 2015/06/26 Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita. Jose Santiago Ibañez Cabellos; Jose Luis García Giménez; Gisselle Perez Machado; Marta Seco Cervera; Esther Berenguer Pascual; Federico Pallardo Calatayud.
Congress
 OXYGEN CLUB OF CALIFORNIA WORLD CONGRESS.
OXYGEN CLUB OF CALIFORNIA , United States
2015/03/09 - 2015/03/11 Alignment-free methods for the detection and specificity prediction of Adenylation domains (Poster/Section: Database and resource development. Miguel Santos, Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Aminael Sánchez-Rodríguez, Agostinho Antunes.
Conference
 4th ISCB-Africa ASBCB Conference in Bioinformatics.
International SOCIETY FOR COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, United States
2015/03/06 - 2015/03/07 Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita. Ibáñez Cabellos, JS; Seco-Cervera, M; Pérez Machado, G; García-Giménez, JL; Berenguer-Pascual, E; Pallardó, FV.
Meeting
 1sT Joint Meeting UT Southwestern and University of Valencia
University of Texas Southwestern Medical School, United States
2014/09/22 - 2014/09/28 Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita. . J.S. Ibáñez-Cabellos, M. Seco-Cervera, G. Pérez-Machado, J.L. García-Giménez, F.V. Pallardó.
Conference
 Biochemical basis of healthy ageing, SFRR-Europe/IUBMB Advanced School. Spetses, Athens
Society for Free Radical Research Europe, United Kingdom
2014 - 2014 Exploring Adenylation Domains Repertoire Of Nonribosomal Peptide Synthetases Using Four-Color Maps. Guillermin Aguero, Reinaldo Molina, Gisselle Perez, Agostinho Antunes.
Conference
 21 Conferencia de Quimica, Universidad de Oriente
Sociedad Cubana de Química, Cuba
2013/06/12 - 2013/06/14 Effect of silencing genes involved in congenital dyskeratosis on cellular antioxidant systems Ibañez-Cabellos JS, Seco-Cervera M, García-Giménez JL, Pérez-Machado G, Pallardó FV
Congress
 55 Congreso de la Sociedad Española de Geriatría y Gerontología. 2 Congreso de la Sociedad Valenciana de Geriatría y Gerontología
Sociedad Española de Geriatría y Gerontología., Spain
2013/02/18 - 2013/02/22 TI2BioP: Topological Indices to Biopolymers. Its practical use to unravel cryptic bacteriocin-like domains. Guillermin Agüero-Chapin, GissellePérez-Machado, Reinaldo Molina-Ruiz, Yunierkis Pérez-Castillo, Aliuska Morales-Helguera, Vítor Vasconcelos and AgostinhoAntunes.
Congress
 2nd BioSyst.EU. 2013.
Society for Biological Systematics, United Kingdom
2011/06/12 - 2011/06/15 Alignment-free Models based on the TI2BioP methodology to identify Rnase III protein members. (Poster). Guillermin Agüero-Chapin, Gustavo A de la Riva, Reinaldo Molina-Ruiz,Aminael Sánchez-Rodríguez, Gisselle Pérez-Machado, Vítor Vasconcelos and Agostinho Antunes.
Meeting
 2nd Iberic Meeting on Medicinal Chemistry.Porto, Portugal.
Universidade do Porto, Portugal
2011/04/01 - 2011/04/01 Neuroleptics as G quadruplex agents? Emply of QSAR and experimental methodology for the discovery of new compounds. (Oral communication). Castillo-Gonzalez Daimel, Pérez-Machado Gisselle, Cabrera-Perez Miguel, Mergny JL.
Seminar
 8th Seminars of Advanced Studies on Molecular Design and Bioinformatics, Habana, Cuba
Universidad de la Habana, Cuba
2011/04/01 - 2011/04/01 Alignment-free Models supported on the TI2BioP methodology to Identify Rnase III Protein Members. Guillermin Agüero-Chapin,Gustavo A de la Riva, Reinaldo Molina-Ruiz, AminaelSánchez-Rodríguez, Gisselle Pérez-Machado, Vítor Vasconcelos and Agostinho Antunes.
Seminar
 8th Seminars of Advanced Studies on Molecular Design and Bioinformatics, Habana, Cuba,
Universidad Agraria de la Habana, Cuba
2010/11/13 - 2010/11/15 Comparative enzymatic activity of three recombinant RNAse III and effect of bacterial RNAseIII expressed in transformed yeasts. De la Riva G.A, Agüero–ChapinG, Morales-Aragón JC, Pérez-Machado G, Vasconcelos V and Antunes A
Congress
 3er Congreso Internacional de Investigación CIPITECH
2010/10/20 - 2010/10/22 Asociación de polimorfismos en genes de reparación con el cáncer de tiroides y con la se nsibilidad a la radiación ionizante. Wilser-Andrés García-Quispes, Pérez G, Marcos R.
Congress
 XIX Congreso de la Sociedad Española de Mutagénesis Ambiental . Coruña. Spain
Sociedad Española de Mutagenesis Ambiental , Spain
2010/09/19 - 2010/09/24 Prediction of telomerase inhibitory activity for triazine derivatives based on chemical structure. Castillo-Gonzalez Daimel, Pérez-Machado Gisselle, Teijeira-Bautista Marta, Cabrera-Perez Miguel Angel.
Symposium
 18th European Symposium on Quantitative Structure – ActivityRelationships “Discovery Informatics & Drug Design” (Rhodes, Greece)
European Federation for Medicinal Chemistry, Belgium
2010/09/19 - 2010/09/24 A general QSAR methodology to predict telomerase inhibition by G-quadruplex stabilization. Castillo-Gonzalez Daimel, Pérez-Machado Gisselle, Aguero-Chapin Guillermin, Mora. Rodas, Grecia, Morales-Helguera Aliuska. Teijeira-Bautista Marta, Cabrera-Perez Miguel Angel.
Symposium
 18th European Symposium on Quantitative Structure–Activity Relationships -EuroQSAR (2010) “Discovery Informatics & Drug Design” (Rhodes, Greece)
European Federation for Medicinal Chemistry, Belgium
2010/06/01 - 2010/06/04 Barberine derivatives as G4 stabilizers agents. A QSAR perspective. Castillo-Gonzalez Daimel, Pérez-Machado Gisselle, Aguero-Chapin Guillermin, Morales-Helguera Aliuska. Teijeira-Bautista Marta,Cabrera-Perez Miguel Angel
Symposium
 IV International Symposium on Chemistry. Santa Clara, Cuba
Sociedad Cubana de Química, Cuba
2010/06/01 - 2010/06/04 Employ of chromones for the prediction of antitelomerase activity by G-quadruplex stabilization. A QSAR approach. Castillo-Gonzalez Daimel, Pérez-Machado Gisselle, Aguero-Chapin Guillermin, Morales-Helguera Aliuska, Borges Fernanda, Cabrera-Perez Miguel Angel.
Symposium
 IV International Symposium on Chemistry, Santa Clara, Cuba
Sociedad Cubana de Química, Cuba
2009/11/09 - 2009/11/13 QSAR study to polymeric sequences embedded in a novel 2D lattice. Guillermin Agüero Chapin, Humberto González-Díaz, Gustavo A de La Riva, Gisselle Pérez-Machado, Agostinho Antunes XIII Congreso Nacional de Bioquímica y Biología Molecular de Plantas. Guanajuato, México.
Centro de Investigación y de Estudios Avanzados , Mexico
2009/11/02 - 2009/11/05 Telomerase inhibitors by G-quadruplex stabilization: A QSAR approach. Daimel Castillo González, Miguel Ángel Cabrera Pérez, Gisselle Pérez Machado, Guillermín Agüero Chapín, Aliuska Morales Helguera.
Congress
 Biotecnología Habana 2009. Aplicaciones Médicas de la Biotecnología. Habana,Cuba
2009/07/17 - 2009/07/20 A new approach of the sub-structural analysis toward the design of A1 Adenosine Receptors Agonists. Marta Teijeria Bautista, Maykel Pérez González, Aliuska Morales Helguera, Guillermín AgueroChapin, Gisselle Pérez Machado, Carmen Terán Moldes. Third Join Italian-German Purine Club Meeting. Purinergic Receptors. New Frontiers for Novel Therapies. Università degli Studi di Camerino, Italy
European Federation for Medicinal Chemistry, Belgium
2006/09/25 - 2006/09/27 Evaluación genotóxica del Hebernem empleando sangre y médula de roedores. Habana 25-27 sep 2006. Lóriga E, Pérez Machado G, Marrero O.
Workshop
 III International and IV Cuban Mutagenesis, Teratogenesis,and Carcinogenesis Workshop.
Universidad de la Habana, Cuba
2006/09/25 - 2006/09/27 Longitud telómerica como biomarcador de daño genotóxico.. Marcos R, Moreno Y, Pérez, Machado G , Surralles J.
Workshop
 III International and IV Cuban Mutagenesis, Teratogenesis,and Carcinogenesis Workshop. Habana Cuba
Universidad de la Habana, Cuba
2006/09/25 - 2006/09/27 Evaluación genotóxica del Hebernem empleando sangre y médula de roedores. Lóriga E, Pérez Machado G, Marrero O.
Workshop
 III International and IV Cuban Mutagenesis, Teratogenesis,and Carcinogenesis Workshop.
Universidad de la Habana, Cuba
2006/09 - 2006/09 Polimorfismos genéticos y cancer de tiroides. Pérez Machado G, Marcos R, Creus A.
Workshop
 III International and IV Cuban Mutagenesis, Teratogenesis,and Carcinogenesis Workshop. Habana Cuba
Universidad de la Habana, Cuba
2006/06/19 - 2006/06/21 POLIMORFISMOS GENÉTICOS COMO MARCADORES DE SUSCEPTIBILIDAD AL CÁNCER DE TIROIDES. Pérez G, Marcos R, Hernández A.
Meeting
 XV Reunión Científica de la Sociedad Española de Mutagénesis Ambiental. Córdoba 2006.
Sociedad Española de Mutagenesis Ambiental , Spain
2005/07/20 - 2005/07/22 Evaluación genotóxica de derivados furiletilénicos y nitrofuranos utilizando el ensayo del cometa en células linfoblastoides humanas”. Oviedo 20-22 julio de 2005. González Borroto J. Pérez Machado G., Creus A., Marcos R.
Meeting
 XIV Reunión Científica de la Sociedad Española de Mutagénesis Ambiental. 2005.
Sociedad Española de Mutagenesis Ambiental , Spain
2004/10/18 - 2004/10/22 Evaluación toxicológica del (1-(5-bromofur-2-il)-2 metil2-nitroeteno) en ratones. Gisselle Pérez Machado, Remigio Cortes Rodríguez, Armando Morales Montero, Esvieta Tenorio Borroto, Osmany Marrero Chang, Edisleydi Aguila Jiménez, Maria del Rosario León Berovides, Osdany Núñez y Deodelsy Bermúdez.
Meeting
 Cuba farmacia 2004. VI Encuentro iberoamericano de farmacia y Alimentos.
Instituto de Farmacia y Alimentos , Universidad de La Habana, Spain
2000/07/05 - 2000/07/07 Genotoxic evaluation of 1-(5-bromofur-2-il)-2-bromo-2-nitroethene (G-1), a novel antimicrobial agent. Bellaterra (Cerdanyola del Vallès) Xu,J. Farrar, K., Nguyen, M.T., Puig,W.,Shore, K., Kamal,J., Carballo, N., Pérez, G., Remigio, A., Fernández, N.,Acebo, A., Carnesoltas, D., Rivero, Y., Contreras, N., Pérez, G., Gonzalez, J.Saínz, O. X Reunión Científica de la Sociedad Española de Mutagénesis Ambiental. 2000.
1998/11/11 - 1998/11/13 Estandarización del Ensayo de Micronúcleos Transplacentarios en sangre de ratones neonatos. Ciudad Habana, Cuba. 1998. Pérez-Machado G, Gonzalez JI , Sain Suarez O.
Congress
 X Congreso Latinoamericano de Toxicología, ALATOX’98.
Asociación latinoamericana de toxicología., Argentina
1998/11/11 - 1998/11/13 Evaluación clastogénica del Bioplant por medio del Ensayo de Micronúcleos ensangre periférica de ratón NMRI. CENPALAB: Ciudad de La Habana, Cuba. 1998.
Workshop
 Taller Latinoamericano sobre Mutagénesis,Teratogénesis y Carcinogénesis. 1998.
Asociación latinoamericana de toxicología., Argentina

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/02/10 Developmet of in vitro diagnostic device for Adolescent Idiopathic Scoliosis diagnosis/prognosis
Supervisor
 Ester Berenguer Pascual (PhD)
Universitat de València, Spain
2021/05/27 Influencia de Factores Epigenéticos en el Desarrollo de la Escoliosis Idiopática Adolescente
President of the jury
 Pedro A. Rubio Belmar (PhD)
Universitat de València, Spain

Conference scientific committee

Conference name Conference host
2020 - Current MOL2NET 2020, International Conference on Multidisciplinary Sciences, Duluth, USA. 6th edition 30/01/2020 - 30/01/2021 - NANOBIOMATJND-02: JSU-NDSU Nanotech. & BioMaterials Science Workshop, Jackson & Fargo, USA, 2020
2020 - Current MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition 30/01/2020 - 30/01/2021 - USEDAT-08: USA-Europe Data Analysis Training Program Workshop, UPV/EHU, Bilbao-MDC, Miami, USA, 2020
2020 - Current MOL2NET 2020, International Conference on Multidisciplinary Sciences, Duluth, USA. 6th edition 30/01/2020 - 30/01/2021 - IWIMSM-04: Iberoamerican Workshop on Model. and Simulation Methods, Valencia, Spain, 2020
2020 - 2021 MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition 30/01/2020 - 30/01/2021 - USINEWS-04: US-IN-EU Worldwide Science Workshop Series, UMN, Duluth, USA, 2020

Consulting

Activity description Institution / Organization
2015 - 2016 Experience writing pharmaceutical registration dossiers, mainly module 2 Dynakin, Spain
2015 - 2015 Research group management, consultation and supervision of preclinical drug evaluation protocols, and ecotoxicological evaluation trials. Consultant on relevant regulations and standards. Quality management system auditor in the pharmaceutical sector. Centro de Bioactuvos Químicos , Cuba

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current MASTER PROPIO EN ENFERMEDADES RARAS 8.ª Edición - Código 20721390 (Master Universitario) Universitat de València, Spain
2018/04/05 - 2021/07/06 EPIGENÉTICA EN MEDICINA Epigenética en Medicina (Postgraduate Certificate) Genotipia, Spain
2016/11 - 2019/06 Master de Fisiología (Master Universitario) Universitat de València, Spain
2018 - 2019 Master Propio en Enfermedades Raras. 7.ª Edición - Código 19721390. Online Titulo propio UV 2019 Master en Enfermedades Raras (Master Universitario) Universitat de València, Spain
2015/10 - 2016/07 •Master en Bases fisiológicas de Investigación biomédica. 2137 (Master Universitario) Universitat de València, Spain
2012/09 - 2016/07 Maestría de Investigación y Desarrollo de medicamentos. Profesor Titular. Facultad de Farmacia. (Master Universitario) Universidad Central Marta Abreu de las Villas, Cuba
2013/09/04 - 2015/07/30 Licenciatura Biología Profesor titular Créditos impartidos:62 horas/anual Asignatura: Genética Departamento y Universidad: Biología, UCLV (Licence) Universidad Central Marta Abreu de las Villas, Cuba
2013 - 2015 Functional Morphology and Molecular Genetics. Full Professor (Licence) Universidad Central Marta Abreu de las Villas. Facultad de Biología , Cuba
2008 - 2013 Conferences on Functional Morphology, Molecular Genetics, Pharmacogenomics. Associated Professor (Licence) Universidad Central de Las Villas - Facultad de Química y Farmacia, Cuba
2000 - 2012 Maestría en Desarrollo de fármacos a partir de productos naturales Fisiopatología , Genética regulatoria, Alternativas terapéuticas de avanzada-Terapia Génica. (Master Universitario) Universidad Central Marta Abreu de las Villas, Cuba
2000 - 2008 Conferences on Functional Morphology, Molecular Genetics, Pharmacogenomics. Assistant Professor (Licence) Universidad Central de Las Villas - Facultad de Química y Farmacia, Cuba
1990 - 1999 Conferences on Anatomy, Molecular Genetics, Toxicology. Assistente Professor (Licence)

Mentoring / Tutoring

Topic Student name
2016 - 2018 Evaluación de la toxicidad del Vitrofural® en agar sobre lombriz de tierra (Eisenia foetida) . Yuleiny Y Mederos Hurtado
2015 - 2017 Potencial genotóxico de Agave brittoniana Trel. subespecie brachypus mediante el ensayo de micronúcleos transplacentarios Sheila de la Caridad Brunet Ramos
2015 - 2016 Estudios ecotoxicológicos en Artemia sp. de aguas residuales de la planta de producción del Centro de Bioactivos Químicos. Rosario Hernandez Armengol
2015 - 2016 Evaluación ecotoxicológica de aguas residuales de la planta de producción del Centro de Bioactivos Químicos empleando tres biomodelos representativos del ecosistema. Edisleidy Aguila Jimenez
2000 - 2001 Estandarización de tres técnicas de genotoxicidad y evaluación genotóxica del bioactivo G-1 y del BIOPLANT. Gema Perez
1996 - 1997 Evaluación del G-1 por medio del Ensayo de Micronúcleo en médula Gsea de ratones Cenp:NMRIn. (Informe). Nelson Carballo
Distinctions

Award

2019 Eureka award for acceleration in innovation and entrepreneurship.
2015 Annual Award of the Cuban Academy of Sciences. "Métodos grafo- numéricos de relevancia para la bioinformática. Aplicaciones en la biotecnología vegetal y en el descubrimiento de fármácos"
Academia de Ciencias de Cuba, Cuba
2013 Annual Regional Award “Development of a graphical and numerical approach for functional annotation and phylogenetic inference in gene/protein families involved in drug discovery”
Ministerio de Ciencia Tecnologia y Medio Ambiente, Cuba
2010 Annual Award “Juan Tomas Roig” for 20 years of University education
Ministerio de Educacion Superior Republica Cuba, Cuba
1994 Annual Award of the Cuban Academy of Sciences “Queratofural. Ungüento Oftálmico de uso Veterinario".
Academia de Ciencias de Cuba, Cuba

Other distinction

2017 Postdoctoral contract Torres Quevedo
Spanish Science and Innovation Ministry , Spain
2016 Profesor contratado doctor
Agencia Nacional de Evaluación de la Calidad y Acreditación, Spain
2016 Profesor Ayudante doctor
Agencia Nacional de Evaluación de la Calidad y Acreditación, Spain
2016 Profesor de Universidad Privada
Agencia Nacional de Evaluación de la Calidad y Acreditación, Spain