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Cristina Elisabete Araújo de Sousa completed her PhD in Science - Specialty Chemistry in 2020 and her Master's in Medicinal Chemistry in 2011 at the University of Minho. Her degree in Biochemistry in 2009 from the University of Porto at the Faculty of Sciences. During her academic career, she published 12 articles in international scientific journals. She organized 3 events and participated in 2 events as a committee member. She has received 2 awards and/or honours. Furthermore, she participated in 5 projects and was co-supervisor in the Medicinal Master Course, Biochemistry Course, Chemistry Course and Biomedical engineering of 9 students. In 2021/2022, she was invited as an Invited Assistant Professor at the University of Minho. Currently, she is a Researcher at the CIETI-LabRISE research unit and serve as a guest editor for the Special Edition "Modelling and Simulation of Proteins, Biopolymers and Biocompatible Materials"
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Identification

Personal identification

Full name
Cristina Elisabete Araújo de Sousa

Citation names

  • Sousa, Cristina
  • Sousa, C. E. A.
  • Sousa, Cristina E. A.

Author identifiers

Ciência ID
C71F-47D0-CAF0
ORCID iD
0000-0001-6561-0975
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=fSwNVooAAAAJ
Researcher Id
F-2805-2014

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Advanced (C1) Upper intermediate (B2)
English Intermediate (B1) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2020/01/24
Concluded
 PhD in Science - Specialty Chemistry (Doutoramento)
Major in Chemistry
Universidade do Minho Escola de Ciências, Portugal
"Synthesis and Computational Studies of Iminosugars Type Products Obtained from D-Erythrose " (THESIS/DISSERTATION)
 Approved with the mention of Very Good
2011/12/16
Concluded
 Master in Medicinal Chemistry (Mestrado)
Major in Medicinal Chemistry
Universidade do Minho Escola de Ciências, Portugal
"A D-Eritrose como sintão para a síntese de iminoaçúcares" (THESIS/DISSERTATION)
 18
2009/07
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Determination of MAPK p38 pathway activity in desmine aggregates" (THESIS/DISSERTATION)
 14.4
Affiliation

Science

Category
Host institution 		Employer
2021/12/01 - 2022/05/03 Researcher (Research) REQUIMTE, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2021/01/06 - 2021/11/18 Postdoc (Research) Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/10/01 - 2022/02/28 Invited Assistant Professor (University Teacher) Universidade do Minho, Portugal

Others

Category
Host institution 		Employer
2018 - 2020 Investigation REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2010/09/06 - 2012/07/27 Scholarship (BI) under the guidance of Prof. Maria José da Chão Alves integrated in the research project PTDC / QUI / 67407/2006 Universidade do Minho Departamento de Química, Portugal
Universidade do Minho Departamento de Química, Portugal
2010/02/28 - 2010/06/24 Research for the synthesis of acetylenic derivatives of D-glucose glycoconjugate precursors containing the 1,2,3-triazole unit under the guidance of Prof. Ana Paula Esteves. Universidade do Minho Departamento de Química, Portugal
2009/10/18 - 2010/01/08 Investigation for the synthesis of 5-amino-4- (cyanoformimidoyl) imidazoles derivatives for evaluation as anti-tuberculosis agents under the guidance of Prof. Alice Maria Esteves Dias. Universidade do Minho Departamento de Química, Portugal
Universidade do Minho Departamento de Química, Portugal
2009/02/02 - 2009/07/24 Research internship (according to the «Eramus» program): «Determination of MAPK p38 pathway activity in desmine aggregates» under the guidance of Prof. Alain Lilienbaum. Université Paris Diderot, France
Université Paris Diderot, France
Projects

Grant

Designation Funders
2021/01/06 - 2021/11/18 Desenvolvimento de testes rápidos para monitorização de anticorpos em soro e saliva
POCI-01-B7-FEDER-69745
Post-doc
Fundação para a Ciência e a Tecnologia
Ongoing
2019/09 - 2020/01 RDB-TS: Uma base de dados de reações químicas baseadas em informação de estados de transição derivados de cálculos quânticos
PTDC/QUIQFI/31689/2017
Master Student Fellow
REQUIMTE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012 - 2015 ESTRATÉGIAS CONCISAS E ESTEREOSELETIVAS DE SÍNTESE DE AZA-AÇÚCARES. ESTUDOS TEÓRICOS E BIOLÓGICOS DOS PRODUTOS.
PTDC/QEQ-MED/1671/2012
Universidade do Minho Departamento de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2011 Estratégia Comum de Síntese de Aza-açúcares e Nucleósidos Modificados. Avaliação Biológica dos Produtos.
PTDC/QUI/67407/2006
Master Student Fellow
Universidade do Minho Departamento de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/12/01 - 2022/05/03 Compreender para tratar: estratégias in vitro e in silico na exploração de novas abordagens terapêuticas no tratamento da deficiência mais comum da beta-oxidação mitocondrial de ácidos gordos (mFAOD)
PTDC/BIA-BQM/29570/2017
Researcher
Concluded
Outputs

Publications

Conference paper
  1. F. Rocha, Juliana; S. Freitas, David; Noro, Jennifer; Silva Teixeira, Carla S.; Sousa, Cristina E. A.; Sousa, Sérgio F.; Alves, Maria J.; Cerqueira, Nuno. "Combined experimental and computational studies devoted to the synthesis of 1,4-lactones". Paper presented in EJIBCE, Porto, 2018.
    Published • 10.3390/mol2net-04-06089
  2. de Sousa, Cristina; Ribeiro, António; Fortes, António; Cerqueira, Nuno; Alves, Maria. "Experimental and Computational Studies Addressed to 1,3-Dipolar Cycloadditions of D-Erythrose 1,3-Dioxane 1,5-Lactone with Regio and Stereo-selectivity". Paper presented in EJIBCE, Porto, 2018.
    Published • 10.3390/mol2net-04-06075
Conference poster
  1. Vieira, Tatiana F.; Sousa, Cristina E. A.; Sousa, Sérgio F.. "A Multi-Level Computational Approach in the Discovery of New Quorum Sensing Inhibitors for P. aeruginosa". Paper presented in Affinity 2021 Meeting, 2021.
  2. Sousa, Cristina E. A.; Pereira, C.; Fernandes, H.S.; Sousa, S.F.; Nuno M. F. S. A. Cerqueira. "RDB-TS: Development of a Database for Storage of Transition State Structures for Organic Reactions". Paper presented in EJIBCE, 2019.
  3. Sousa, Cristina E. A.; Nuno M. F. S. A. Cerqueira; Alves, Maria José Chão. "Synthesis of D-glucono- 1-N-benzyl-1,5-lactone from D-erythrose 1,3-dioxane derivative; computational mechanistic studies". Paper presented in 5th PYCheM and 1st EYCHeM, 2016.
  4. Sousa, Cristina E. A.; Maria José da Chão Alves. "Enantioselective Diels-Alder cycloaddition in the synthesis of Pyridazine compounds". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  5. Jennifer Noro; Vera C.M. Duarte; Paulo Silva; Sousa, Cristina E. A.; A. Gil Fortes; Maria José da Chão Alves. "Síntese de um análogo da ceramida a partir da D-glucose como potencial inibidor de ß-glucosidades". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  6. Sousa, Cristina E. A.; Alves, Maria José Chão. "SYNTHESIZE OF AZIRIDINES FROM DIAZO-DIAZIRINE COMPOUNDS". Paper presented in 4th Portuguese Young Chemists Meeting, 2014.
  7. Maria José da Chão Alves; António M. P. Ribeiro; Sousa, Cristina E. A.; A. Gil Fortes. "Enantiospecific 1,3-Dipolar Cycloadditions between Azadienophiles and 2-Phenyl-4,4a-dihydropyrano[3,2-d][1,3]dioxin-6(8aH)-one". Paper presented in 6th Spanish Portuguese Japanese Organic Chemistry Symposium, 2012.
  8. Sousa, Cristina E. A.; Alves, Maria José Chão; A. Gil Fortes. "SYNTHESIS OF (2'R,4A'R,8A'S)-8'-(BENZYLAMINO)-2'-PHENYLDIHYDRO4'H-SPIRO[DIAZIRINYL-1,7'-PYRANO[3,2-D][1,3]DIOXIN]-6'(4A'H)-ONE". Paper presented in 6th Spanish Portuguese Japanese Organic Chemistry Symposium, 2012.
  9. António M. P. Ribeiro; Sousa, Cristina E. A.; Alves, Maria José Chão; A. Gil Fortes. "1, 3-Dipolar Cycloaddition of (2R, 4aR, 8aS)-2-phenyl-4, 4a-dihydropyrano [3, 2-d][1, 3] dioxin-6 (8aH)-one with Aromatic Diazomethyl Compounds". Paper presented in 3rd Portuguese Young Chemists Meeting, 2012.
  10. Sousa, Cristina E. A.; Alves, Maria José Chão; A. Gil Fortes; A.L. Salgueiro, Daniela; Vera C.M. Duarte. "Highly 1,3-dipolar additions of dienophiles to dipolarophiles bearing a D-erythrose unit as a chiral inductor". Paper presented in 9th International Meeting of the Portuguese Carbohydrate Chemistry Group/ 5th Iberian Carbohydrate Meeting, 2011.
  11. Sousa, Cristina E. A.; Alves, Maria José Chão; A. Gil Fortes; A.L. Salgueiro, Daniela; Vera C.M. Duarte. "The synthesis of an homochiral aziridine as a useful synton to iminosugars and amino acid compounds". Paper presented in XXII Encontro Nacional da SPQ, 2011.
  12. A.L. Salgueiro, Daniela; Alves, Maria José Chão; Vera C.M. Duarte; A. Gil Fortes; Sousa, Cristina E. A.; Micaelo, N.M.. "Synthesis of 1-azafagomine analog and 1-N-phenyl carboxamide 1-azafagomine containing erythrose units". Paper presented in XXII Encontro Nacional da SPQ, 2011.
  13. Esteves, A.; Rodrigues L.; Sousa, Cristina E. A.; Suarez A, Cunha S. "Synthesis of Glucosy-based 1,2,3-Triazoles by "Click" Chemistry". Paper presented in Second Iberoamerican Symposium on Organic Chemistry (SIBEAQO-II), 2010.
  14. Sousa, Cristina E. A.; Alice Maria E. Dias. "Síntese de derivados de 5-amino-4- (cianoformimidoil) imidazoles para avaliação como agentes antituberculose". Paper presented in 2as Jornadas de Química Medicinal, 2010.
Journal article
  1. Tarsila G. Castro; Manuel Melle-Franco; Cristina E. A. Sousa; Artur Cavaco-Paulo; João C. Marcos. "Non-Canonical Amino Acids as Building Blocks for Peptidomimetics: Structure, Function, and Applications". Biomolecules (2023): https://doi.org/10.3390/biom13060981.
    10.3390/biom13060981
  2. Correia, Bárbara P.; Sousa, Mariana P.; Sousa, Cristina E. A.; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Matos, Ana Miguel; Pereira, Ana Cláudia; Moreira, Felismina T. C.. "Development of colorimetric cellulose-based test-strip for the rapid detection of antibodies against SARS-CoV2 virus". Cellulose 29 17 (2022): 9311-9322. http://dx.doi.org/10.1007/s10570-022-04808-y.
    Published • 10.1007/s10570-022-04808-y
  3. Cristina Elisabete Araújo de Sousa; Daniela Salgueiro; Maria J. Alves. "Concise Synthesis of (S)-7-Hydroxy-8a-epi-D-5-aza-swainsonine from a D-Erythrose Derivative". Synthesis (2022): https://doi.org/10.1055/a-1768-2082.
    10.1055/a-1768-2082
  4. Pinheiro, Tomás; Cardoso, A. Rita; Sousa, Cristina E. A.; Marques, Ana C.; Tavares, Ana P. M.; Matos, Ana Miguel; Cruz, Maria Teresa; et al. "Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic". ACS Omega 6 44 (2021): 29268-29290. http://dx.doi.org/10.1021/acsomega.1c04012.
    10.1021/acsomega.1c04012
  5. Cristina E. A. Sousa; Maria J. Alves. "Synthesis of novel sugar derived aziridines, as starting materials giving access to sugar amino acid derivatives". Amino Acids (2021): https://doi.org/10.1007/s00726-021-03017-4.
    10.1007/s00726-021-03017-4
  6. David S. Freitas; Cristina E. A. Sousa; Joana Parente; Artem Drogalin; António Gil Fortes; Nuno M. F. S. A. Cerqueira; Maria J. Alves. "(3S,4R)-3,4-Dihydroxy-N-alkyl-l-homoprolines: synthesis and computational mechanistic studies". Organic & Biomolecular Chemistry (2019): https://doi.org/10.1039/C9OB02141H.
    10.1039/C9OB02141H
  7. Rocha, Juliana F.; Freitas, David S.; Noro, Jennifer; Silva Teixeira, Carla S.; Sousa, Cristina E. A.; Alves, Maria J.; Cerqueira, Nuno M. F. S. A.. "Total Stereoselective Michael Addition of N- and S- Nucleophiles to a d-Erythrosyl 1,5-Lactone Derivative. Experimental and Theoretical Studies Devoted to the Synthesis of 2,6-Dideoxy-4-functionalized-d-ribono-hexono-1,4-lactone". The Journal of Organic Chemistry 83 15 (2018): 8011-8019. http://dx.doi.org/10.1021/acs.joc.8b00769.
    Published • 10.1021/acs.joc.8b00769
  8. Sousa, Cristina E. A.; Ribeiro, António M. P.; Gil Fortes, António; Cerqueira, Nuno M. F. S. A.; Alves, Maria J.. "Total Facial Discrimination of 1,3-Dipolar Cycloadditions in a d-Erythrose 1,3-Dioxane Template: Computational Studies of a Concerted Mechanism". The Journal of Organic Chemistry 82 2 (2017): 982-991. http://dx.doi.org/10.1021/acs.joc.6b02518.
    Published • 10.1021/acs.joc.6b02518
  9. Sousa, Cristina; Mendes, Raquel; Costa, Flora; Duarte, Vera; Fortes, António; Alves, Maria. "Synthesis of Iminosugars from Tetroses". Current Organic Synthesis 11 2 (2014): 182-203. http://dx.doi.org/10.2174/15701794113106660074.
    Published • 10.2174/15701794113106660074
  10. A.L. Salgueiro, Daniela; E.A. Sousa, Cristina; Gil Fortes, A.; Jose Alves, M.. "Diels-Alder Cycloaddition in the Synthesis of 1-Azafagomine, Analogs, and Derivatives as Glycosidase Inhibitors". Mini-Reviews in Medicinal Chemistry 12 14 (2012): 1465-1476. http://dx.doi.org/10.2174/138955712803832663.
    10.2174/138955712803832663
  11. Salgueiro, Daniela; Sousa, Cristina; Duarte, Vera; Gil Fortes, António; Alves, Maria. "Diastereoselectivity in Diels-Alder Cycloadditions of Erythrose Benzylidene-acetal 1,3-Butadienes with Maleimides". Synlett 23 12 (2012): 1765-1768. http://dx.doi.org/10.1055/s-0031-1289785.
    Published • 10.1055/s-0031-1289785
  12. Dias, Alice; Cabral, Isabel; Vila-Chã, A.; Cunha, Daniela; Senhorães, Nádia; Nobre, Sandra; Sousa, Cristina; Proença, M.. "A Facile One-Pot Synthesis of 3-Imidazolyl 1,2,4-Triazoles and 1,2,4-Oxa­diazolones". Synlett 2010 18 (2010): 2792-2796. http://dx.doi.org/10.1055/s-0030-1258820.
    Published • 10.1055/s-0030-1258820
Thesis / Dissertation
  1. Sousa, Cristina E. A.. "Synthesis and Computational Studies of Iminosugars Type Products Obtained from D-Erythrose". PhD, Universidade do Minho, 2020.
  2. Sousa, Cristina E. A.. "A D-Eritrose como sintão para a síntese de iminoaçúcares". Master, Universidade do Minho, 2011. http://hdl.handle.net/1822/18279.
  3. Sousa, Cristina E. A.. "Determination of MAPK p38 pathway activity in desmine aggregates". Degree, Universidade do Porto Faculdade de Ciências, 2009.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/01/20 Synthesis and Computational Studies of Iminosugars Type Products obtained from D-Erythrose 1st BioSIM Cycle of Conferences
(Porto, Portugal)
2018/03/06 Diels-Alder cycloaddition in the synthesis of Pyridazine and Swainsonine analogs 5th Young Research Fellow Meeting
French Medicinal Chemistry Society (Orléans, France)
2016/11/10 Total Facial Discrimination of 1,3-Dipolar Cycloadditions in a D-Erythrose 1,3- Dioxane Template. Computational Studies of Mechanism XXII Encontro Luso Galego de Química
Sociedade Portuguesa de Química (Bragança, Portugal)
2011/09 Asymmetric Diels-Alder Cycloadditions in the Synthesis of Iminosugars Meeting on Iminosugars in the International Year of Chemistry
(Santiago de Compostela., Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02/02 - Current Development of an enzymatic sensor for the detection of cholesterol
Co-supervisor
 Engenharia Biomédica (Master)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2011/07/03 - 2011/07/06 Collaborator in the Organizing Committee during the XXII Meeting SPQ National (2011/07/03 - 2011/07/06)
Congress (Other)
 Universidade do Minho, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/09/24 - 2021/09/24 European Researchers Night 2021, SCIENCE CASTLE
Exhibition
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2021/06/29 - 2021/06/29 8th BiotechHealth Annual Symposium - Biotech Talks | The Future is Now
Symposium
 8th BiotechHealth Annual Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/04/27 - 2020/04/29 MedChemTrain e-School 2020, a virtual event aiming to bring together the scientific community and share some updates in the medicinal chemistry field.
Conference
 Disseminating state of the art research in Medicinal Chemistry during these quarantine times.

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/03/22 Rational design and synthesis of novel selective PI3K inhibitors for cancer therapy.
(Thesis) Arguer
 Vítor Daniel Pereira Lobo (Master)
Universidade do Minho Escola de Ciências, Portugal

Committee member

Activity description
Role 		Institution / Organization
2018/12/21 - 2018/12/21 Member of the organizing committee of the Youth Meeting Structural Computational Biology Researchers (EJIBCE)
Member
 Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016 Member of the organizing committee of the 5th Portuguese Youth Meeting Chemists (PYCheM) and the 1st European Meeting of Young Chemists (EYCHeM)
Member
 Universidade do Minho, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10/01 - 2022/02/28 Molecular Modeling Master Degree in Medicinal Chemistry and Master Degree in in Applied Biochemistry (Mestrado) Universidade do Minho, Portugal

Interview (tv / radio show)

Program Topic
2022 - 2022/02/22 TECH3 program Tech 3 is a small format that addresses topics such as creativity, innovation, technology and knowledge.

Mentoring / Tutoring

Topic Student name
2024/02/01 - Current Development of a potentiometric biosensor for the detection of a biomarker associated with Alzheimer's disease Francisca De Barros
2017 - 2018 Advisor and supervisor in the laboratory in the Msc Medicinal Course Joana Filipa Parente
2016 - 2018 Advisor and supervisor in the laboratory in the Msc Medicinal Course David da Silva Freitas
2014 - 2014 Advisor and supervisor in the laboratory in the Bsc Chemistry Course Paulo Henrique Barbosa da Rocha Rodrigues
2014 - 2014 Advisor and supervisor in the laboratory in the Bsc Biochemistry Course Joana de Santos Martins
2014 - 2014 Advisor and supervisor in the laboratory in the Bsc Biochemistry Course Juliana Ferreira Rocha
2012 - 2013 Advisor and supervisor in the laboratory in the Msc Medicinal Course António Manuel Pereira Ribeiro
2012 - 2013 Advisor and supervisor in the laboratory in the Msc Medicinal Course Ana Cristina Olival
Distinctions

Award

2023 Scientific Publication Merit Certificate - PAPRE 2023
Instituto Politécnico do Porto, Portugal
2014 Honorable mention for the work presented at 4th Portuguese Young Chemists Meeting
Universidade de Coimbra Centro de Química de Coimbra, Portugal