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João Filipe da Costa Martins obtained his PhD in Biomedical Sciences in 2015 from the University of Coimbra. He has been working in Neurosciences and Vision Sciences. He has published 42 journal articles, mostly in first-quartile journals, with more than 1200 citations and an h-index of 19. João has developed his research studies at the University of Coimbra, Portugal; the Vision Institute in Paris, France; the University of Copenhagen, Denmark; and NOVA University Lisbon, Portugal. He has been involved in more than 20 research projects and has been supervising PhD, MSc, and BSc students in Biology, Biochemistry, and Biomedical Engineering. In 2021, João was awarded a Seed Project at the Institute for Nuclear Sciences Applied to Health (ICNAS), - Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, as Principal Investigator, to study neuroplasticity mechanisms in animal models of neurodevelopmental differences using functional magnetic resonance imaging (fMRI) and in vivo electrophysiology (ePhys). The main research interest is to understand basic brain physiology, taking advantage of multimodal brain imaging, namely fMRI and ePhys using rodent species. In particular, the aim is to unravel how neurodevelopment disorders affect cortical plasticity with behavioural consequences. Under this topic, the development of novel techniques combining functional brain imaging with electrophysiology and behaviour are pursuit, as means to uncover new biomarkers and understand disease mechanisms. João uses various techniques, ranging from fundamental cellular and molecular biology and microscopy to rodent behavioral tests, in vitro and in vivo ePhys, optical coherence tomography, and fMRI. His other activities include serving as reviewer for scientific journals in Neuroscience and Vision Science, acting as jury of BSc and MSc degrees, and speaking at Brain Awareness Week dissemination events, including laboratory and school visits.
Identification

Personal identification

Full name
João Filipe da Costa Martins

Citation names

  • Martins, João

Author identifiers

Ciência ID
C61F-E0B3-BC6A
ORCID iD
0000-0001-7764-286X

Email addresses

  • joao.martins@icnas.uc.pt (Professional)

Addresses

  • ICNAS - Institute for Nuclear Sciences Applied to Health, Azinhaga de Santa Comba, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
2015/05/29
Concluded
Ciências da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Modulation of Retinal Ganglion Cell Function and Implications for Neuroprotection" (THESIS/DISSERTATION)
Approved with distinction and honors
2010/09/14
Concluded
Course in Laboratory Animal Science (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/05/14
Concluded
Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effects of 3,4-methylenedioxymethamphetamine administration on rat electroretinogram" (THESIS/DISSERTATION)
Very Good
2006/09/15
Concluded
Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"The proliferative effect of neuropeptide Y in rat retinal cell cultures " (THESIS/DISSERTATION)
16
Outputs

Publications

Book chapter
  1. Elisa J. Campos; António Campos; Martins, João; António Francisco Ambrósio. "Nanotools for the Treatment of Ocular Diseases". In Nanomaterials and Nanotechnology in Medicine, 169-184. Wiley, 2022.
    10.1002/9781119558026.ch7
Journal article
  1. Ferreira, Helena; Santos, Sofia; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Distinct early development trajectories in Nf1± and Tsc2± mouse models of autism". Journal of Neurodevelopmental Disorders 17 1 (2025): https://doi.org/10.1186/s11689-025-09624-6.
    10.1186/s11689-025-09624-6
  2. Pais, Mariana Lapo; Sereno, José; Tomé, Vanessa A.; Fonseca, Carla; Seco, Camila; Ribeiro, Inês; Martins, João; et al. "Sex-specific cortical networks drive social behavior differences in an autism spectrum disorder model". Translational Psychiatry 15 1 (2025): https://doi.org/10.1038/s41398-025-03464-7.
    10.1038/s41398-025-03464-7
  3. Fortunato, Maria Carolina; Neves, João; Pais, Mariana Lapo; Fonseca, Carla; Silva, Daniela; Martins, João; Castelo-Branco, Miguel; Fortuna, Ana; Gonçalves, Joana. "Maternal Tryptophan Supplementation Alters Offspring Gut-Brain Axis and Behavior in a Sex-Specific Manner". Journal of Neurochemistry 169 7 (2025): https://doi.org/10.1111/jnc.70161.
    10.1111/jnc.70161
  4. Ribeiro, Francisco M.; Gonçalves, Joana; Coelho, Luís; Castelo-Branco, Miguel; Martins, João. "Sex-Dependent Variations of Retinal Function and Architecture in a Neurofibromatosis Type I Mouse Model with Normal Vision". Experimental Eye Research (2025): 110279. https://doi.org/10.1016/j.exer.2025.110279.
    10.1016/j.exer.2025.110279
  5. Oliveira, Sara; Guimarães, Pedro; Campos, Elisa Julião; Fernandes, Rosa; Martins, João; Castelo-Branco, Miguel; Serranho, Pedro; et al. "Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy". Investigative Ophthalmology & Visual Science 66 1 (2025): 7. https://doi.org/10.1167/iovs.66.1.7.
    10.1167/iovs.66.1.7
  6. Gomes-Ribeiro, Joana; Martins, João; Sereno, José; Deslauriers-Gauthier, Samuel; Summavielle, Teresa; Coelho, Joana E; Remondes, Miguel; Castelo-Branco, Miguel; Lopes, Luísa V. "Mapping functional traces of opioid memories in the rat brain". Brain Communications (2024): http://dx.doi.org/10.1093/braincomms/fcae281.
    10.1093/braincomms/fcae281
  7. Pais, Mariana L.; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Increased susceptibility to kainate-induced seizures in a mouse model of tuberous sclerosis complex: Importance of sex and circadian cycle". Epilepsia Open (2024): http://dx.doi.org/10.1002/epi4.12955.
    10.1002/epi4.12955
  8. Caramelo, Beatriz; Monteiro-Alfredo, Tamaeh; Martins, João; Sereno, José; Castelhano, João; Manadas, Bruno; Castelo-Branco, Miguel; Matafome, Paulo. "Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models". Journal of Neurochemistry 165 6 (2023): 892-906. http://dx.doi.org/10.1111/jnc.15825.
  9. Santos, Sofia; Martins, Beatriz; Sereno, José; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Neurobehavioral sex-related differences in Nf1+/- mice: female show a 'camouflaging'-type behavior". Biology of Sex Differences 14 1 (2023): http://dx.doi.org/10.1186/s13293-023-00509-8.
    10.1186/s13293-023-00509-8
  10. Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1161847.
    10.3389/fnagi.2023.1161847
  11. Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al. "Retinal imaging in animal models: Searching for biomarkers of neurodegeneration". Frontiers in Ophthalmology 3 (2023): http://dx.doi.org/10.3389/fopht.2023.1156605.
    10.3389/fopht.2023.1156605
  12. Pais, Mariana Lapo; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders". International Journal of Molecular Sciences 24 6 (2023): 6010. http://dx.doi.org/10.3390/ijms24066010.
    10.3390/ijms24066010
  13. Ribeiro, Francisco M.; Castelo-Branco, Miguel; Gonçalves, Joana; Martins, João. "Visual Cortical Plasticity: Molecular Mechanisms as Revealed by Induction Paradigms in Rodents". International Journal of Molecular Sciences 24 5 (2023): 4701. http://dx.doi.org/10.3390/ijms24054701.
    10.3390/ijms24054701
  14. Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Stage-independent biomarkers for Alzheimer's disease from the living retina: an animal study". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18113-y.
    10.1038/s41598-022-18113-y
  15. Palavra, Filipe; Viana, Sofia D.; Henriques, Sara; Dinis, João; Martins, João; Madeira, Maria H.; Santiago, Raquel; et al. "Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?". Multiple Sclerosis and Related Disorders 63 (2022): 103886. http://dx.doi.org/10.1016/j.msard.2022.103886.
    10.1016/j.msard.2022.103886
  16. Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195.
    10.3389/fnagi.2022.832195
  17. Sousa, Beatriz; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Transcranial Direct Current Stimulation as an Approach to Mitigate Neurodevelopmental Disorders Affecting Excitation/Inhibition Balance: Focus on Autism Spectrum Disorder, Schizophrenia, and Attention Deficit/Hyperactivity Disorder". Journal of Clinical Medicine 11 10 (2022): 2839. http://dx.doi.org/10.3390/jcm11102839.
    10.3390/jcm11102839
  18. Santos, Sofia; Ferreira, Helena; Martins, João (C61F-E0B3-BC6A); Gonçalves, Joana; Castelo-Branco, Miguel. "Male sex bias in early and late onset neurodevelopmental disorders: shared aspects and differences in autism spectrum disorder, attention deficit/hyperactivity disorder, and schizophrenia". Neuroscience and Biobehavioral Reviews (2022):
    Published • 10.1016/j.neubiorev.2022.104577
  19. Ferreira, Helena; Sereno, José; Martins, João (C61F-E0B3-BC6A); Castelo-Branco, Miguel; Gonçalves, Joana; Sousa, Ana C. "Sex-dependent social and repetitive behavior and neurochemical profile in mouse model of autism spectrum disorder". Metabolites (2022):
    Published • 10.3390/metabo12010071
  20. Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António. F.; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterisation of changes in the 3xTg-AD mice model of Alzheimer's disease". Aging (2021):
    Accepted • 10.18632/aging.202916
  21. Campos, António; Martins, João; Campos, Elisa; Silva, Rufino; Ambrósio, António F.. "Choroidal and retinal structural, cellular and vascular changes in a rat model of Type 2 diabetes". Biomedicine & Pharmacotherapy 132 (2020): 110811.
    Published • 10.1016/j.biopha.2020.110811
  22. Rodrigues, Flávia S. C.; Campos, António; Martins, João; Ambrósio, A. F.; Campos, Elisa. "Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses". ACS Biomaterials Science & Engineering (2020):
    Published • 10.1021/acsbiomaterials.0c01347
  23. Campos, António; Campos, Elisa J.; Martins, João; Rodrigues, Flávia SC.; Silva, Rufino; Ambrósio, António Francisco. "Inflammatory cells proliferate in the choroid and retina without choroidal thickness change in early Type 1 diabetes". Experimental Eye Research (2020): 108195. http://dx.doi.org/10.1016/j.exer.2020.108195.
    Published • 10.1016/j.exer.2020.108195
  24. Campos, António; Campos, Elisa J.; Martins, João; Ambrósio, António Francisco; Silva, Rufino. "The value of choroidal thickness in diabetic macular oedema is contradictory". Acta Ophthalmologica (2020): http://dx.doi.org/10.1111/aos.14529.
    Published • 10.1111/aos.14529
  25. Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro; Bernardes, Rui. "Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease". Health and Technology (2020):
    Published • https://doi.org/10.1007/s12553-020-00413-w
  26. Cavaleiro, Carla; Martins, João; Gonçalves, Joana; Castelo-Branco, Miguel. "Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review". Neural Plasticity 2020 (2020): 1-23. http://dx.doi.org/10.1155/2020/4795267.
    Open access • Published • 10.1155/2020/4795267
  27. Campos, Elisa J.; Martins, João; Brudzewsky, Dan; Woldbye, David P.D.; Ambrósio, António F.. "Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model". Annals of Anatomy - Anatomischer Anzeiger 227 (2020): 151419. http://dx.doi.org/10.1016/j.aanat.2019.151419.
    Open access • Published • 10.1016/j.aanat.2019.151419
  28. Campos, António; Campos, Elisa J; do Carmo, Anália; Caramelo, Francisco; Martins, João; Sousa, João P; Ambrósio, António Francisco; Silva, Rufino. "Evaluation of markers of outcome in real-world treatment of diabetic macular edema". Eye and Vision 5 1 (2018): http://dx.doi.org/10.1186/s40662-018-0119-9.
    Open access • Published • 10.1186/s40662-018-0119-9
  29. Martins, João; Alves, Mariana R. P.; Boia, Raquel; Campos, Elisa J.; Nunes, Sara; Madeira, Maria H.; Santiago, Ana R.; et al. "Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes". Molecular Vision 24 (2018): 353-366.
    Open access • Published
  30. Campos, Elisa J; Martins, João; Brudzewsky, Dan; Correia, Sandra; Santiago, Ana R; Woldbye, David PD; Ambrósio, António F. "Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina". Clinical & Experimental Ophthalmology 46 7 (2018): 783-795. http://dx.doi.org/10.1111/ceo.13176.
    Open access • Published • 10.1111/ceo.13176
  31. Campos, Elisa J.; Campos, António; Martins, João; Ambrósio, António Francisco. "Opening eyes to nanomedicine: Where we are, challenges and expectations on nanotherapy for diabetic retinopathy". Nanomedicine: Nanotechnology, Biology and Medicine 13 6 (2017): 2101-2113. http://dx.doi.org/10.1016/j.nano.2017.04.008.
    Published • 10.1016/j.nano.2017.04.008
  32. Campos, António; Campos, Elisa J.; Martins, João; Ambrósio, António Francisco; Silva, Rufino. "Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema". Acta Ophthalmologica 95 5 (2016): 446-459. http://dx.doi.org/10.1111/aos.13210.
    Open access • Published • 10.1111/aos.13210
  33. Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; et al. "Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective ActionsIn Vitro". ASN Neuro 7 4 (2015): 175909141559829. http://dx.doi.org/10.1177/1759091415598292.
    Open access • Published • 10.1177/1759091415598292
  34. Gonçalves, Joana; Martins, João; Baptista, Sofia; Ambrósio, António Francisco; Silva, Ana Paula. "Effects of drugs of abuse on the central neuropeptide Y system". Addiction Biology 21 4 (2015): 755-765. http://dx.doi.org/10.1111/adb.12250.
    Published • 10.1111/adb.12250
  35. Martins, João; Kolomiets, Bogdan; Caplette, Romain; Sahel, José-Alain; Castelo-Branco, Miguel; Ambrósio, António F.; Picaud, Serge. "Sildenafil Acutely Decreases Visual Responses in ON and OFF Retinal Ganglion Cells". Investigative Opthalmology & Visual Science 56 4 (2015): 2639. http://dx.doi.org/10.1167/iovs.14-15964.
    Open access • Published • 10.1167/iovs.14-15964
  36. Santos-Carvalho, Ana; Álvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia. "Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection". Progress in Neurobiology 112 (2014): 70-79. http://dx.doi.org/10.1016/j.pneurobio.2013.10.002.
    Published • 10.1016/j.pneurobio.2013.10.002
  37. Froger, Nicolas; Cadetti, Lucia; Lorach, Henri; Martins, Joao; Bemelmans, Alexis-Pierre; Dubus, Elisabeth; Degardin, Julie; et al. "Taurine Provides Neuroprotection against Retinal Ganglion Cell Degeneration". PLoS ONE 7 10 (2012): e42017. http://dx.doi.org/10.1371/journal.pone.0042017.
    Open access • Published • 10.1371/journal.pone.0042017
  38. Martins, João; Castelo-Branco, Miguel; Batista, Ana; Oliveiros, Bárbara; Santiago, Ana Raquel; Galvão, Joana; Fernandes, Eduarda; et al. "Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat". PLoS ONE 6 12 (2011): e29583. http://dx.doi.org/10.1371/journal.pone.0029583.
    Open access • Published • 10.1371/journal.pone.0029583
  39. Leal, E. C.; Martins, J.; Voabil, P.; Liberal, J.; Chiavaroli, C.; Bauer, J.; Cunha-Vaz, J.; Ambrosio, A. F.. "Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes". Diabetes 59 10 (2010): 2637-2645. http://dx.doi.org/10.2337/db09-1421.
    Open access • Published • 10.2337/db09-1421
  40. Álvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia. "Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide". Journal of Neurochemistry 105 6 (2008): 2501-2510. http://dx.doi.org/10.1111/j.1471-4159.2008.05334.x.
    Open access • Published • 10.1111/j.1471-4159.2008.05334.x
  41. Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C.. "Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy". Neuroscience 152 1 (2008): 97-105. http://dx.doi.org/10.1016/j.neuroscience.2007.12.027.
    Published • 10.1016/j.neuroscience.2007.12.027
  42. Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al. "NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells". Neurochemistry International 50 5 (2007): 757-763. http://dx.doi.org/10.1016/j.neuint.2007.01.010.
    Published • 10.1016/j.neuint.2007.01.010
Preprint
  1. Martins, Beatriz; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Neuropeptide Y causes sex dependent changes in microbiota-intestinal-brain communication in a mouse model of autism spectrum disorder". 2024. http://dx.doi.org/10.21203/rs.3.rs-4441928/v1.
    10.21203/rs.3.rs-4441928/v1
  2. Gomes-Ribeiro, Joana; Martins, João; Sereno, José; Deslauriers-Gauthier, Samuel; Summavielle, Teresa; Coelho, Joana E.; Remondes, Miguel; Branco, Miguel Castelo; Lopes, Luísa V.. "Mapping functional traces of opioid memories in the rat brain". 2023. http://dx.doi.org/10.1101/2023.08.07.552221.
    10.1101/2023.08.07.552221
  3. Ferreira, Helena; Santos, Sofia; Martins, João; Castelo-Branco, Miguel; Gonçalves, Joana. "Fleeting: a Novel Ultrasonic Vocalization in Mice That Allows to Define Altered Developmental Milestones in Autism Spectrum Disorder". 2022. http://dx.doi.org/10.21203/rs.3.rs-1169877/v1.
    10.21203/rs.3.rs-1169877/v1
Thesis / Dissertation
  1. Martins, João. "Modulation of Retinal Ganglion Cell Function and Implications for Neuroprotection". PhD, Universidade de Coimbra Faculdade de Medicina, 2015. https://estudogeral.sib.uc.pt/handle/10316/26530.
  2. Martins, João. "Effects of 3,4-methylenedioxymethamphetamine administration on rat electroretinogram". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.
  3. Martins, João. "The proliferative effect of neuropeptide Y in rat retinal cell cultures". Degree, Universidade do Porto Faculdade de Ciências, 2006.

Other

Dataset
  1. Martins, João; Ribeiro, Francisco M. Retinal structure and function of NF1 mice. Mendeley Data. 2025.
    10.17632/cy9h3chr48.1