Personal identification

Full name

Sónia Daniel Glória Simão

Citation names

• Simão, Sónia
• Simão, S

Author identifiers

Ciência ID

C612-D462-A564

Knowledge fields

• Natural sciences - Biological Sciences - Cell Biology

	Degree	Classification
2016 Concluded	Metabolic Diseases and Eating Behavior (Curso de mestrado (conclusão do curso de especialização)) Universidade de Lisboa Faculdade de Medicina, Portugal
2011 Concluded	Biomedicine (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal "Regulation of the Cl- / HCO3- (Slc26a6) exchanger in a genetic model of hypertension" (THESIS/DISSERTATION)
2004 Concluded	Biochemistry (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal "Susceptibility of rabbit skeletal muscle myosin sub-fragment 1 to peroxynitrite" (THESIS/DISSERTATION)

Grant

	Designation	Funders
2026/01/01 - 2027/12/31	From Mechanism to Biomarker: Redox Control of Stress Granules as a Neuroregenerative Driver in Alzheimer’s Disease Bolsa Pereira Monteiro de Apoio à Investigação Translacional em Neurologia (2025) Principal investigator	Sociedade Portuguesa de Neurologia

Contract

	Designation	Funders
2021 - Current	ABC coLAB: ABC Collaborative Laboratory: Integrated Aging and Rejuvenation Solutions ABC colab Researcher	Fundação para a Ciência e a Tecnologia
2024 - 2026	T21S-SH – Tackling impaired neurodevelopment in Down Syndrome via identification of S-sulfhydration targets: a new role for the gasotransmitter hydrogen sulfide signaling in neurodevelopment 2379-GRT-2024A Researcher	Fondation Jérôme Lejeune
2022 - 2024	Identification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment EXPL/MED-NEU/1240/2021 Researcher	Fundação para a Ciência e a Tecnologia
2021 - 2024	ALgarve Fit Ageing (ALFA) Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável SAICT-2020-072586 Researcher Algarve Biomedical Center Research Institute - ABC-RI, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Algarve Ongoing
2020 - 2022	SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord MC-39-2019 Researcher	Santa Casa da Misericórdia de Lisboa Ongoing
2018 - 2021	GT-LightUP: Signaling Gasotransmitters Light Up PTDC/QUI-QFI/29319/2017 Researcher Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2014/01/01 - 2015	RASRET - Role of the renin-angiotensin system in retinal diseases and its therapeutic potential EXPL/BIM-MEC/1433/2013 Co-Principal Investigator (Co-PI) Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	Regulatory effects of pattern recognition receptors (prrs) in electrolyte transport and membrane potential in intestinal epithelial cells PTDC/SAU-TOX/117664/2010 Researcher Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2010	Oxidative stress and genetic markers of cardiovascular risk in hypertension PIC/IC/83204/2007 Researcher Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004 - 2007	Antinatriuretic agents and the renal bicarbonate handling in hypertension POCI/SAU-OBS/59207/2004 Research Fellow Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2022 - 2024	SNO-PD: Contribution of S-Niitrosylation for the aggregation of alfa-synuclein in Parkinson's disease 2021.09515.CBM Researcher	Fundação para a Ciência e a Tecnologia Ongoing

Publications

Book chapter	Agostinho, Rafaela; Simão, Sónia; Martínez-Ruiz, Antonio; Araújo, Inês Maria. "Dimedone Switch Method in Induced Pluripotent Stem Cells". In Methods in Molecular Biology. Springer Nature, 2026. Accepted
Conference abstract	Simão, Sónia. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in 2021 ARVO Annual Meeting, 2021. Simão, Sónia. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), Lisboa, 2018. Published Simão, Sónia. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 53rd EASD Annual Meeting, Lisboa, 2017. Published Simão, Sónia. "Increased expression of (pro)renin and (pro)renin receptor correlates with the progression of diabetic retinopathy". Paper presented in 16th EURETINA Congress, copenhaga, 2016. Published Simão, Sónia. "Hyperglycemia and hypoxia induce overexpression of GLUT1 in models of Diabetic Retinopathy". Paper presented in 51st EASD Annual Meeting, estocolmo, 2015. Published Simão, Sónia. "The role of GLUT1 in the pathogenesis of Diabetic Retinopathy". Paper presented in ESGCT and FSGT Collaborative Congress, Elsinquia, 2015. Published Simão, Sónia. "Anti-angiogenic VEFG isoform is markedly decreased in the retina of diabetic mice". Paper presented in ESGCT and NVGCT Collaborative Congress, Haia, 2014. Published Simão, Sónia. "Insights on the role of the Renin-Angiotensin System in diabetic retinopathy". Paper presented in ESGCT and NVGCT Collaborative Congress, Haia, 2014. Published Simão, Sónia. "Renin is expressed in D407 human retinal cells". Paper presented in European Society of Hypertension and International Society of Hypertension, Atenas, 2014. Published Simão, Sónia. "Glucose and H2O2 modulate the expression of VEGF isoforms in human retinal cells". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013. Simão, Sónia. "Carotenoid-based lipoplexes efficiently transfect retinal pigment epithelium cells". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013. Simão, Sónia. "pEPito-based vectors enable long-term expression in mouse models of diabetic retinopathy". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013. Simão, Sónia. "H2O2 modulates the expression of VEGF isoforms in retinal cells". Paper presented in ESGCT and SFTCG Collaborative Congress, Versailles, 2012. Simão, Sónia. "H2O2 Increases Cl-/HCO3- Exchanger Activity through Oxidation of Thiol Groups in Spontaneously Hypertensive Rats Renal Cells". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011. Published Simão, Sónia. "Isolated Systolic Hypertension in Old WKY Rats is Associated With Oxidative Stress and Metabolic Derangements: Effect of Dietary Restriction". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011. Published Simão, Sónia. "Slc26 Transporters Involved in Cl-/HCO3- Exchange Activity in Wistar Kyoto and Spontaneously Hypertensive Rats Proximal Tubular Epithelial Cells". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011. Published Simão, Sónia. "The Renal Dopaminergic System and Amino Acid Transporter Expression in Aged WKY and SHR Rats". Paper presented in European Meeting on Hypertension, Milan, 2011. Published Simão, Sónia. "Enhanced Susceptibility to Oxidative Stress Induced Cell Death in SHR is Linked to Reduced Catalase Activity and Increased JNK Activation". Paper presented in European Meeting on Hypertension, Milan, 2011. Published Simão, Sónia. "Oxidative stress and renal mineralcorticoid receptor expression in aged wistar kyoto (WKY) and spontaneously hypertensive (SHR) rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009. Published Simão, Sónia. "Lack of effect of antioxidant therapy with apocynin, a NADPH oxidase inhibitor, against oxidative stress and elevated blood pressure in SHR rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009. Published Simão, Sónia. "Aging and Na,K-ATPase activity and expression in kidney and jejunum of normotensive and spontaneously hypertensive rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009. Published Simão, Sónia. "Differences in H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in WKY and SHR Immortalized Renal Proximal Tubular Cells". Paper presented in 19th European Meeting on Hypertension, Milan, 2009. Published Simão, Sónia. "Unique Profile In Renal Mineralocorticoid Receptor Expression Change In Aged Spontaneously Hypertensive Rats". Paper presented in 63rd Annual High Blood Pressure Research Conference, Chicago, 2009. Published Simão, Sónia. "Effect Of Food Restriciton Upon Mineralocorticoid Receptor Expression And Function In Young And Aged Wistar Kyoto Rats". Paper presented in 63rd Annual High Blood Pressure Research Conference, Chicago, 2009. Published Simão, Sónia. "Resistance of immortalized renal cells from WKY and SHR rats to oxidative stress is associated with activation of multiple MAPK signaling pathways". Paper presented in 18th European Meeting on Hypertension, Berlin, 2008. Published Simão, Sónia. "Oxidative Stress Plays a Permissive Role in a1-AR-Induced Stimulation of Cl-/HCO3- Exchanger in Immortalized SHR Proximal Tubular Epithelial Cells". Paper presented in 18th European Meeting on Hypertension, Berlin, 2008. Published Simão, Sónia. "Involvement of H2O2 in Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity in Immortalized SHR Cells". Paper presented in 61st Annual High Blood Pressure Research Conference, Tucson, 2007. Simão, Sónia. "Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity through alpha1-Adrenergic Receptors in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Paper presented in 17th European Meeting on Hypertension, Milan, 2007. Published Simão, Sónia. "a2-AR Stimulation and Cl-/HCO3- Exchanger Activity in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Paper presented in 17th European Meeting Hypertension, Milan, 2007. Published Simão, Sónia. "Oxidative Stress and a2-Adrenoceptor-mediated Events in Immortalized Proximal Tubular Epithelial Cells from the Spontaneously Hypertensive Rat". Paper presented in 61st Annual High Blood Pressure Research Conference, Tucson, 2007. Published Simão, Sónia. "Role of PKC on the regulation of enhanced Cl-/HCO3- exchanger activity in hypertension". Paper presented in XLIII ERA-EDTA Congress, Glasgow, 2006. Simão, Sónia. "Norepinephrine and Cl-/HCO3- Exchanger Activity in Immortalized SHR cells". Paper presented in XLIII ERA-EDTA Congress, Glasgow, 2006. Published
Conference poster	Agostinho, Rafaela; Teixeira, Mariana; MASCARENHAS MARQUES, VERA; Martínez-Ruiz, Antonio; Simão, Sónia; Araújo, Inês Maria. "Optimization of Dimedone Switch Method for detection of S-sulfhydrated proteins in human induced pluripotent stem cells derived from Down syndrome individuals". Paper presented in 2nd FEBS Redox Medicine Workshop, 2025. Teixeira, Mariana; Agostinho, Rafaela R.; Martínez-Ruiz, Antonio; Outeiro, Tiago; Araújo, Inês Maria; Simão, Sónia. "Identification of S-nitrosylation targets contributing to pathological aggregation of alpha-synuclein in Parkinson´s Disease: a proteomic study". Paper presented in 2nd FEBS Redox Medicine Workshop, 2025. Teixeira, Mariana; Simão, Sónia; Outeiro, Tiago; Araújo, Inês Maria. "Identification of S-nitrosylation targets contributing to pathological aggregation of alpha-synuclein in Parkinson´s disease: a proteomic study". Paper presented in Encontro Ciência 2025, 2025. Santos, Daniela F.; Simão, Sónia; Araújo, Inês Maria. "Oxidative profile of a cohort of young versus aged individuals in the Algarve region". Paper presented in HEAT-NET Frontiers in Neurodegeneration: from bench to bedside, 2024. Agostinho, Rafaela; MARQUES, VERA; Sofia M. Calado; Bragança, José; Nzwalo, Hipólito; Mónica Bota; Raquel Melo Medeiros; et al. "Cystathionine beta-synthase and H2S levels are increased in cellular models of trisomy 21". Paper presented in FENS Forum 2024, 2024. Simão, Sónia. "Characterization of Adult Neurogenesis in Acomys cahirinus by Lineage Tracing Analysis". Paper presented in IX Clinical Biochemistry Workshop, 2024. Simão, Sónia. "Dysregulation of H2S levels in a cellular model of Down Syndrome". Paper presented in IX Clinical Biochemistry Workshop, 2024. Simão, Sónia. "Illuminating Neurogenesis: Unveiling Acomys cahirinus newborn neurons by lineage tracing imaging". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting, 2023. Simão, Sónia. "Assessment of H2S production in fibroblasts by time-lapse fluorescence imaging prior to establishment of fibroblast-derived iPS cell lines". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting, 2023. Simão, Sónia. "Redox profiling of a cohort of young versus old individuals in the Algarve region". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023. Simão, Sónia. "New model of brain disorders in Acomys cahirinus: from brain mapping to accurate stereotaxic coordinates". Paper presented in FENS Regional Meeting, 2023. Simão, Sónia. "Characterization and modulation of H2S production in fibroblasts derived from Down Syndrome individuals by time-lapse fluorescence imaging". Paper presented in FENS Regional Meeting, 2023. Simão, Sónia. "Brain Atlas of Acomys cahirinus: Creating tools to study brain regeneration". Paper presented in VII Symposium Portuguese Glial Network, 2023. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. "Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023. Simão, Sónia. "Brain Atlas of Acomys cahirinus: a new tool for regenerative studies". Paper presented in Ageing without borders, 2022. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Paper presented in ABC-Days, 2022. Simão, Sónia. "New corrole-based H2S fluorescent probes for time-lapse imaging in cultured cells". Paper presented in IV Jornadas Algarve Biomedical Center, 2021. Simão, Sónia. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in 2021 ARVO Annual Meeting, 2021. Simão, Sónia. "Rewired glycosyltransferase activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Paper presented in Encontro Ciência 2021, 2021. Simão, Sónia. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), 2018. Simão, Sónia. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 2nd Annual CBMR Meeting, 2017. Simão, Sónia. "Hyperglycemia modulates the renin-angiotensin system in retinal pigment epithelial cells". Paper presented in 1st Annual CBMR Meeting, 2016. Simão, Sónia. "Identification of neurogenic S-­nitrosylation targets in neural stem cells". Paper presented in 1st Annual CBMR Meeting, 2016. Simão, Sónia. "Hybrid strategies for retinal gene therapy". Paper presented in 8th Intern Meeting of the Portuguese Soc. Stem Cells & Cell Therapies, 2013. Simão, Sónia. "Activation of the aldosterone/MR system by aging in spontaneously hypertensive rats". Paper presented in European Society of Hypertension (ESH) 2012: 22nd European Meeting on Hypertension and Cardiovascular Protection, 2012. Simão, Sónia. "Increased Responsiveness to JNK1/2 Mediates the Enhanced H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in SHR PTE cells". Paper presented in 4thNational Meeting on Signal Transduction SINAL, 2010. Simão, Sónia. "Increased susceptibility of renal cells from SHR to H2O2 is associated with activation of multiple MAPK signaling pathways and impaired antioxidant/oxidant balance". Paper presented in Gordon Research Conferences – Oxigen Radicals, 2008. Simão, Sónia. "Skeletal Muscle Myosin-S1 Susceptibility to Peroxynitrite". Paper presented in XIV Congresso Nacional de Bioquímica, 2004. 10.1183/13993003.congress-2019.pa4309 Simão, Sónia. "Free-Radical Mediated Effects on Myosin and Actin from Skeletal Muscle". Paper presented in 1st Luso-Spanish Congress on Free Radicals, 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
Journal article	Agostinho, Rafaela; Calado, Sofia M.; Bragança, José; Nzwalo, Hipólito; Marques, Vera Mascarenhas; Bota, Mónica; Medeiros, Raquel Melo; et al. "Establishment and characterization of induced pluripotent stem cell lines from individuals with down syndrome and age-matched euploid donors". Stem Cell Research (2026): 103932. https://doi.org/10.1016/j.scr.2026.103932. Open access • Published • 10.1016/j.scr.2026.103932 De Sousa-Coelho, Ana Luísa; Araújo, Inês Maria; Simão, Sónia. Corresponding author: Simão, Sónia. "Liver–Brain Crosstalk in Obesity: Linking Metabolic Dysfunction to Neurodegeneration". Biomolecules (2026): Accepted Simão, Sónia; Santos, Daniela F.; Teixeira, Mariana; Agostinho, Rafaela R.; Rodrigues, Joana; Vitorino, Marta; Araújo, Inês M.. Corresponding author: Simão, Sónia. "Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer’s and Parkinson’s diseases". Redox Report 31 1 (2025): https://doi.org/10.1080/13510002.2025.2592413. Open access • Published • 10.1080/13510002.2025.2592413 Esteves, Filipa; Vilhena Catarino Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia; Andrade, Raquel; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): 103576. Open access • 10.1016/j.scr.2024.103576 Santos, Daniela F.; Simão, Sónia; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro; Araújo, Inês M.; ALFA Score Consortium. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14995. 10.1002/1873-3468.14995 Filipa Esteves; David Brito; Ana Teresa Rajado; Nádia Silva; Joana Apolónio; Vânia Palma Roberto; Inês Araújo; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. Open access • 10.1016/j.mad.2023.111854 Simão, Sónia; Agostinho, Rafaela Ribeiro; Martínez-Ruiz, Antonio; Araújo, Inês Maria. Corresponding author: Simão, Sónia. "Regulation of Ras Signaling by S-Nitrosylation". Antioxidants 12 8 (2023): 1562. http://dx.doi.org/10.3390/antiox12081562. Published • 10.3390/antiox12081562 Santos, Carla I.M.; Santiago, Ana M.; Araújo, Ana R.L.; Pinto, Sandra; Agostinho, Rafaela R.; Simão, Sónia; Azevedo, Tomás P.; et al. "New fluorescent probes based on gallium(III) corrole complexes for the recognition of hydrogen sulfide: A journey from solution to intracellular site". Dyes and Pigments 216 (2023): 111304. http://dx.doi.org/10.1016/j.dyepig.2023.111304. Published • 10.1016/j.dyepig.2023.111304 Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David V.C.; Apolónio, Joana; Roberto, Vânia; Binnie, Alexandra; et al. "Measuring healthy ageing: current and future tools". Biogerontology 24 6 (2023): 845. Open access • Published Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; et al. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): http://dx.doi.org/10.18632/aging.204668. Published • 10.18632/aging.204668 D V C, Brito; F, Esteves; A T, Rajado; N, Silva; I, Araújo; J, Bragança; P, Castelo-Branco; A, Sardo; Simão, Sónia. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies.". npj aging 9 (2023): Vitorino, Marta; Simão, Sónia; Moreira, João B.; Nogueira-Rodrigues, Joana; Silva, Joana; Lourenço, Ana Sofia; Fernandes, Vítor; et al. "Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, Acomys cahirinus". Journal of Comparative Neurology 530 12 (2022): 2215-2237. https://doi.org/10.1002/cne.25329. Published • 10.1002/cne.25329 Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell 57 4 (2022): 440-450.e7. http://dx.doi.org/10.1016/j.devcel.2021.12.008. Published • 10.1016/j.devcel.2021.12.008 Bitoque, Diogo B.; Morais, Joana; Oliveira, Ana V.; Sequeira, Raquel L.; Calado, Sofia M.; Fortunato, Tiago M.; Simão, Sónia; Rosa da Costa, Ana M.; Silva, Gabriela A.. "Human-derived NLS enhance the gene transfer efficiency of chitosan". Bioscience Reports 41 1 (2021): http://dx.doi.org/10.1042/bsr20201026. Published • 10.1042/bsr20201026 Santos, Ana Isabel; Lourenço, Ana Sofia; Simão, Sónia; Marques da Silva, Dorinda; Santos, Daniela Filipa; Onofre de Carvalho, Ana Paula; Pereira, Ana Catarina; et al. "Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics". Redox Biology 32 (2020): 101457. http://dx.doi.org/10.1016/j.redox.2020.101457. Published • 10.1016/j.redox.2020.101457 Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells". Angiogenesis 20 1 (2017): 175-181. http://dx.doi.org/10.1007/s10456-016-9526-5. 10.1007/s10456-016-9526-5 Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells". European Journal of Pharmaceutical Sciences 92 (2016): 22-27. http://dx.doi.org/10.1016/j.ejps.2016.06.019. 10.1016/j.ejps.2016.06.019 Sofia M. Calado; Simão, Sónia; B Bitoque, Diogo; M Calado, Sofia; A Silva, Gabriela. "Oxidative stress modulates the expression of VEGF isoforms in models of diabetic retinopathy". New Frontiers in Ophthalmology 2 2 (2016): http://oatext.com/Oxidative-stress-modulates-the-expression-of-VEGF-isoforms-in-the-diabetic-retina.php. Published • 10.15761/NFO.1000119 Simão, Sónia. "Oxidative stress modulates the expression of VEGF isoforms in the diabetic retina". New Frontiers in Ophthalmology 2 1 (2016): 77-83. https://oatext.com/Oxidative-stress-modulates-the-expression-of-VEGF-isoforms-in-the-diabetic-retina.php. Open access • Published Simão, Sónia. "GLUT1 activity contributes to the impairment of PEDF secretion by the RPE". Molecular Vision 22 (2016): 761-770. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943856/. Open access • Published Bitoque, Diogo B.; Simão, Sónia; Oliveira, Ana V.; Machado, Susana; Duran, Margarita R.; Lopes, Eduardo; da Costa, Ana M. Rosa; Silva, Gabriela A.. "Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina". Journal of Tissue Engineering and Regenerative Medicine 11 1 (2014): 265-275. http://dx.doi.org/10.1002/term.1909. 10.1002/term.1909 Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. "Identification of SLC26A transporters involved in the Cl-/HCO3- exchange in proximal tubular cells from WKY and SHR". Life Sciences 93 12-14 (2013): 435-440. http://dx.doi.org/10.1016/j.lfs.2013.07.026. 10.1016/j.lfs.2013.07.026 Gomes, Pedro; Simão, Sónia; Lemos, Vera; Amaral, João S.; Soares-da-Silva, Patrício. "Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation". Free Radical Biology and Medicine 56 (2013): 112-122. http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.017. 10.1016/j.freeradbiomed.2012.11.017 Pinto, Vanda; Pinho, Maria João; Silva, Elisabete; Simão, Sónia; Igreja, Bruno; Afonso, Joana; Serrão, Maria Paula; Gomes, Pedro; Soares-da-Silva, Patrício. "Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: A comparison with SHR". Experimental Gerontology 47 8 (2012): 644-653. http://dx.doi.org/10.1016/j.exger.2012.05.022. 10.1016/j.exger.2012.05.022 Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. "H2O2 stimulates Cl-/HCO¿3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells". Journal of Cellular Biochemistry 112 12 (2011): 3660-3665. http://dx.doi.org/10.1002/jcb.23299. 10.1002/jcb.23299 Pinto, Vanda; Amaral, João; Silva, Elisabete; Simão, Sónia; Cabral, José Miguel; Afonso, Joana; Serrão, Maria Paula; et al. "Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats". Mechanisms of Ageing and Development 132 6-7 (2011): 298-304. http://dx.doi.org/10.1016/j.mad.2011.06.003. 10.1016/j.mad.2011.06.003 Simão, Sónia; Gomes, Pedro; Pinto, Vanda; Silva, Elisabete; Amaral, João S.; Igreja, Bruno; Afonso, Joana; et al. "Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats". Experimental Gerontology 46 6 (2011): 468-474. http://dx.doi.org/10.1016/j.exger.2011.02.003. 10.1016/j.exger.2011.02.003 Silva, E.; Pinto, V.; Simão, S.; Serrão, M.P.; Afonso, J.; Amaral, J.; Pinho, M.J.; Gomes, P.; Soares-da-Silva, P.. "Renal aging in WKY rats: Changes in Na+,K+-ATPase function and oxidative stress". Experimental Gerontology 45 12 (2010): 977-983. http://dx.doi.org/10.1016/j.exger.2010.09.012. 10.1016/j.exger.2010.09.012 Simão, S.; Gomes, P.; Jose, P.A.; Soares-da-Silva, P.. "Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR". Biochemical Pharmacology 80 6 (2010): 913-919. http://dx.doi.org/10.1016/j.bcp.2010.05.013. 10.1016/j.bcp.2010.05.013 Simão, S; Fraga, S; Jose, P A; Soares-da-Silva, P. "Oxidative stress and a1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". British Journal of Pharmacology 153 7 (2009): 1445-1455. http://dx.doi.org/10.1038/bjp.2008.16. 10.1038/bjp.2008.16 Gomes, Pedro; Simão, Sónia; Silva, Elisabete; Pinto, Vanda; Amaral, João S.; Afonso, Joana; Serrão, Maria Paula; Pinho, Maria João; Soares-da-Silva, Patrício. "Aging increases Oxidative Stress and Renal Expression of Oxidant and Antioxidant Enzymes that Are Associated with an Increased Trend in Systolic Blood Pressure". Oxidative Medicine and Cellular Longevity 2 3 (2009): 138-145. http://dx.doi.org/10.4161/oxim.2.3.8819. 10.4161/oxim.2.3.8819 Simão, Sónia; Pedrosa, Rui; Hopfer, Ulrich; Mount, David B.; Jose, Pedro A.; Soares-da-Silva, Patrício. "Short-term regulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". Biochemical Pharmacology 75 11 (2008): 2224-2233. http://dx.doi.org/10.1016/j.bcp.2008.03.003. 10.1016/j.bcp.2008.03.003 Simão, Sónia; Fraga, Sónia; Jose, Pedro A.; Soares-da-Silva, Patrício. "Oxidative stress plays a permissive role in a2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells". Molecular and Cellular Biochemistry 315 1-2 (2008): 31-39. http://dx.doi.org/10.1007/s11010-008-9785-6. 10.1007/s11010-008-9785-6 Pedrosa, Rui; Villar, Van Anthony M.; Pascua, Annabelle M.; Sima~o, So´nia; Hopfer, Ulrich; Jose, Pedro A.; Soares-da-Silva, Patri´cio. "H 2 O 2 Stimulation of the Cl - /HCO 3 - Exchanger by Angiotensin II and Angiotensin II Type 1 Receptor Distribution in Membrane Microdomains". Hypertension 51 5 (2008): 1332-1338. http://dx.doi.org/10.1161/hypertensionaha.107.102434. 10.1161/hypertensionaha.107.102434 Tiago, Teresa; Simão, Sónia; Aureliano, Manuel; Martín-Romero, Francisco Javier; Gutiérrez-Merino, Carlos. "Inhibition of Skeletal Muscle S1-Myosin ATPase by Peroxynitrite". Biochemistry 45 11 (2006): 3794-3804. http://dx.doi.org/10.1021/bi0518500. 10.1021/bi0518500
Magazine article	Conceição, Natércia; Simão, Sónia; Araújo, Inês Maria. "Modelos Animais em Investigação Biomédica: Uma Estratégia Pedagógica para o Desenvolvimento de Competências Científicas", CNaPPES , 2025 Simão, Sónia. "Como é que a formação de novos neurónios é estimulada a seguir a uma lesão cerebral provocada por crises epilépticas?", UALgoritmo: a ciência trocada por miúdos, 2021
Thesis / Dissertation	Simão, Sónia. "Regulation of CI/HCO3 Exchanger in a Genetic Model of Hypertension". PhD, Universidade do Porto Faculdade de Medicina, 2011. Simão, Sónia. "Suscepibility of S1 fragment of myosin from rabbit skeletal muscle to peroxynitrite". Degree, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2004.