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Cláudia Daniela Canelas Miranda Simões. Completed the Mestrado integrado in Biotecnologia in 2011 by Universidade de Lisboa Instituto Superior Técnico, Doutoramento in Biotecnologia e Biociências in 2016/04/28 by Universidade de Lisboa Instituto Superior Técnico and Licenciatura in Bioquímica in 2009 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Is Contracted Researcher in Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento and Invited Assistant in Universidade de Lisboa Instituto Superior Técnico. Published 8 articles in journals. Has 2 section(s) of books. Participated in 1 event(s). Participates and/or participated as Post-doc Fellow in 1 project(s), Research Fellow in 1 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology, Engineering and Technology with emphasis on Medical Engineering, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry and Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Health-Related Biotechnology. In their professional activities interacted with 52 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Stem Cell Engineering for Regenerative Medicine; Biotechnology; .
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Identification

Personal identification

Full name
Cláudia Daniela Canelas Miranda Simões

Citation names

  • Miranda, Cláudia
  • Miranda, Cláudia C.

Author identifiers

Ciência ID
C519-E3D0-A3BF
ORCID iD
0000-0001-8602-6014

Email addresses

  • claudiamiranda@accelbio.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Health Sciences - Substance Abuse
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Advanced (C1)
Education
Degree Classification
2021/02/18 - 2021/02/23
Concluded
 Teaching STEM Students - a Workshop for Teaching Assistants (Outros)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/04/28
Concluded
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Aggregate-based Systems for Production of Neural Progenitors from Human Pluripotent Stem Cells" (THESIS/DISSERTATION)
 Pass with Distinction
2015/01/29
Concluded
 Biotecnologia e Biociências (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Instituto Superior Técnico, Portugal
 18/20
2011
Concluded
 Biotecnologia (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Towards Fully Defined Culture Systems for Human Induced Pluripotent Stem Cell Expansion" (THESIS/DISSERTATION)
 17.3/20
2009
Concluded
 Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Estudo da citotoxicidade e genotoxicidade do alcenilbenzeno miristicina em linhas celulares de leucemia mielóide crónica K562, sensíveis e resistentes ao fármaco Imatinib." (THESIS/DISSERTATION)
 14.4/20
Affiliation

Science

Category
Host institution 		Employer
2023/01 - Current Research Assistant (Research) CoLAB AccelBio, Portugal
CoLAB AccelBio, Portugal
2019/04/01 - 2022/12/31 Contracted Researcher (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2016/07/15 - 2019/03/31 Postdoc (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2016/02/01 - 2016/07/14 Researcher (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Instituto de Biotecnologia e Bioengenharia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/02 - 2023/08/31 Invited Assistant (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal

Others

Category
Host institution 		Employer
2011/02/01 - 2016/01/31 PhD Student Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Projects

Grant

Designation Funders
2021/02/01 - 2025/01/31 New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling
PTDC/EQU-EQU/3853/2020
Researcher
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Ongoing
2023/02/15 - 2024/08/14 NervousHeart: Engineering an innervated heart organoid – the initial step for in vitro modulation of neuro-cardiac cross-talk
2022.02251.PTDC.
Researcher
Instituto de Biotecnologia e Bioengenharia, Portugal
Ongoing
2019/04/01 - 2019/05/31 MINI-HEARTS - Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays
PTDC/EMD-TLM/29728/2017
Research Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/03/31 I&D UID/BIO/04565/2019
UID/BIO/04565/2019
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
2017/07/16 - 2018/12/31 Institute for Bioengineering and Biosciences
info:eu-repo/grantAgreement/FCT/5876/147338/PT
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/15 - 2017/07/14 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
info:eu-repo/grantAgreement/FCT/5665-PICT/137185/PT
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/02 - 2016/01 PhD Grant
SFRH/BD/78758/2011
PhD Student Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/01 - 2014/12 Bioengineering the Neural Commitment of Human Pluripotent Stem Cells: Rational Approaches for the Clinical-Grade Production of Neuronal Cells
grant.Provided by PTCRIS: 133316
 Fundação para a Ciência e a Tecnologia
Concluded
2012/01 - 2014/12 StemPure - Bioprocess for Production and Purification of Human Pluripotent Stem Cell-derived Neural Cells for Regenerative Medicine Applications
grant.Provided by PTCRIS: 122504
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/01/01 - 2024/12/31 Análise da desregulação neuroimmune na doença de Alzheimer para uma terapia com miRNAs veiculados por exosomas
PTDC/MED-NEU/2382/2021
10.54499/PTDC/MED-NEU/2382/2021
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2012/01/01 - 2014/12/31 StemPure - Bioprocesso para a Produção e Purificação de Células Neurais diferenciadas a partir de Células Estaminais Pluripotentes Humanas para aplicações em Medicina Regenerativa
PTDC/EBB-BIO/122504/2010
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Miranda, Cláudia C.; Cabral, Joaquim M.S.. "Organoids for cell therapy and drug discovery". In Precision Medicine for Investigators, Practitioners and Providers, 461-471. Elsevier, 2020.
    10.1016/b978-0-12-819178-1.00045-9
  2. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, M. Margarida; Cabral, Joaquim M. S.. "Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling". In Advances in Biochemical Engineering/Biotechnology. Springer Berlin Heidelberg, 2019.
    10.1007/10_2019_117
Conference abstract
  1. Rita Padinha Lopes; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "Metabolite profile of synthetic cannabinoids seized in Portugal". Paper presented in Lisbon Addictions 2024, 2024.
  2. Rita Padinha Lopes; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "The neurotoxic effects of psychoactive cathinones and their reduced metabolites. The role of metabolism". Paper presented in 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology, 2024.
  3. Rita Padinha Lopes; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "The neurotoxic effects of emerging synthetic cathinones and its metabolites: the role of metabolism". Paper presented in 15th National Organic Chemistry Meeting and 8th National Medicinal Chemistry Meeting, 2024.
  4. Rita Padinha Lopes; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "Synthesis of psychoactive cathinones and its metabolites: the role of metabolism". Paper presented in 3rd Chem&Biochem Students Meeting, 2023.
  5. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Salvador, William O.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Development of a High-Density System for the Expansion of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in International Conference on Advanced Research on Sustainability and Intelligent Manufacturing RESIM 2022, Marinha Grande, 2022.
  6. Akenhead, Michael L.; Silva, Teresa P.; Derr, Michael A.; Vemuri, Mohan C.; Cabral, Joaquim; Fernandes, Tiago G.. Corresponding author: Fernandes, Tiago G.. "A Dynamic 3D Aggregate-Based System for the Successful Expansion and Neural Induction of Human Pluripotent Stem Cells". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Braga, 2022.
  7. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Development of a High-Density System for Expansion and Cardiac Differentiation of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in 6th TERMIS World Congress, Maastricht, 2021.
  8. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion and Cardiac Differentiation of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in 12th European Symposium on Biochemical Engineering Sciences, Portoroz, 2021.
  9. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M.S.. "Expansion and CardiaDifferentiation of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in 12th European Symposium on Biochemical Engineering Sciences, Portoroz, 2021.
  10. Barata, Tiago; Miranda, Cláudia C.; Vaz, Sandra; Ferreira, Carla S.; Quintas, Alexandre; Bekman, Evguenia. "Cannabinoids affect differentiation of human iPSC-derived neurons". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisbon, 2019.
    10.3389/conf.fncel.2019.01.00040
  11. Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM bioreactors.". Paper presented in 257th National Meeting & Exposition of the American Chemical Society, Orlando, Florida, 2019.
  12. Miranda, Cláudia C.. "Towards multi-organoid systems for drug screening applications". Paper presented in Organoids & 3D Tissue Models Workshop, London, 2019.
  13. Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM Bioreactors.". Paper presented in 12th Symposium of the European Society of Biochemical Engineering Sciences, Lisbon, 2018.
  14. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Upscaling Neural Commitment of Human Pluripotent Stem Cells Using Dual SMAD Inhibition in Suspension Conditions". Paper presented in 10th European Symposium on Biochemical Engineering Sciences, Dublin, 2016.
  15. Miranda, Cláudia C.; Fernandes, Tiago G.; Pascoal, Jorge F.; Haupt, Simone; Brüstle, Oliver; Cabral, Joaquim M. S.. "Spatial and Temporal Control of Cell Aggregation Efficiently directs Human Pluripotent Stem Cells towards Neural Commitment". Paper presented in 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Oeiras, 2015.
  16. Diogo, Maria Margarida; Miranda, Cláudia C.; Fernandes, Tiago G.; Pascoal, Jorge F.; Cabral, Joaquim M. S.. "Temporal And Spatial Control Of The Neural Commitment Of Human Pluripotent Stem Cells As Suspension Aggregates". Paper presented in Scale-Up and Manufacturing of Cell-Based Therapies IV, San Diego, 2015.
  17. Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Towards fully defined conditions for human induced pluripotent stem cell expansion". Paper presented in MicroBiotec’11, Braga, 2011.
Conference paper
  1. Bekman, Evguenia; Barata, Tiago; Miranda, Cláudia; Vaz, Sandra; Ferreira, Carla; Quintas, Alexandre. "Might synthetic cannabinoids influence neural differentiation?". Paper presented in Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, Monte da Caparica, 2021.
    Published • 10.1080/07853890.2021.1893997
  2. Miranda, C.C.; Pascoal, J.F.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Expansion and neural commitment of human pluripotent stem cells as 3D suspension aggregates". 2014.
Conference poster
  1. Rita Padinha Lopes; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "Neurotoxic effects of synthetic cathinones: is there a role for metabolism?". Paper presented in CQE Days, 2024.
  2. Rita Padinha Lopes; Tiago Vicente; Maria Ferreira; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "The potential role of metabolism in the neurotoxic events of synthetic cathinones". Paper presented in Ciências Research & Innovation Day, 2023.
  3. Iryna Vykhlyantseva; Mariana Moço; Fernandes, Tiago G.; Cabral, Joaquim; Miranda, Cláudia C.. "Engineering advanced human kidney organoids for assessing drug-induced toxicity". Paper presented in 2023 ETRS & SPCE-TC Annual Meeting, 2023.
  4. Rita Padinha Lopes; Tiago Vicente; Maria Ferreira; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "Neurotoxic effects of synthetic cathinones and its metabolites.: the potential role of metabolism". Paper presented in XXVIII Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  5. Rita Padinha Lopes; Tiago Vicente; Maria Ferreira; Miranda, Cláudia C.; Gaspar, Helena; Antunes, Alexandra. "Neurotoxic effects of Synthetic Cathinones: the potential role of metabolism". Paper presented in CQE Days, 2023.
  6. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Salvador, William O.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion and Cardiac Differentiation of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in 27th ESACT Meeting, 2022.
  7. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Salvador, William O.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Expansion and Cardiac Differentiation of Human Pluripotent Stem Cells as Aggregates in Vertical-Wheel Bioreactors". Paper presented in 27th ESACT Meeting, 2022.
  8. Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Y.; Jung, S.; Lee, B.; Cabral, Joaquim M.S.. "Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel(TM) bioreactors". Paper presented in TECHNOBEAT Symposium on iPS Based Cell Therapies - From Bench to Bedside, 2019.
  9. Miranda, Cláudia C.; Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in TECHNOBEAT Pre X-Mas Symposium on iPS Based Cell Therapies – From Bench to Bedside, 2019.
  10. Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-Wheel Bioreactors". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Lisbon, Portugal, 2019.
  11. Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
  12. Miranda, Cláudia C.; Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in Ciência 2019, 2019.
  13. Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Miranda, Cláudia C.; Hashimura, Y.; Jung, S.; Lee, B.; Cabral, Joaquim M.S.. "Human pluripotent stem cell expansion in vertical-wheel bioreactors". Paper presented in ECI Advancing Manufacture of Cell and Gene Therapies VI, 2019.
  14. Rodrigues, Carlos A.V.; Nogueira, Diogo E. S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Human pluripotent stem cell expansion as aggregates in Vertical-Wheel bioreactors". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, 2019.
  15. Miranda, Cláudia C.; Fernandes, Tiago G.; Pinto, Sandra N.; Prieto, Manuel; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "A Scale Out Approach Towards Neural Induction of Human Induced Pluripotent Stem Cells for Neurodevelopmental Toxicity Studies". Paper presented in 11th European Symposium on Biochemical Engineering, 2018.
  16. Nogueira, Diogo E. S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM Bioreactors". Paper presented in Ciência 2018, 2018.
  17. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells". Paper presented in ISSCR 2017 Annual Meeting, 2017.
  18. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells". Paper presented in Scale-up and Manufacturing of Cell-based Therapies V, 2017.
  19. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, Maria Margarida; Pascoal, Jorge F.; Cabral, Joaquim M.S.. "Expansion and Neural Commitment of Human Pluripotent Stem Cells as 3D Suspension Aggregates". Paper presented in 13th Annual Meeting of the International Society for Stem Cell Research (ISSCR), 2015.
  20. Miranda, Cláudia C.; Fernandes, Tiago G.; Pascoal, Jorge F.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Expansion and Neural Commitment of Human Pluripotent Stem Cells as 3D Suspension Aggregates". Paper presented in ISSCR Annual Meeting 2015, 2015.
  21. Miranda, Cláudia C.; Pascoal, Jorge F.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Expansion and Neural Commitment of Human Pluripotent Stem Cells as 3D Suspension Aggregates". Paper presented in 10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses, 2014.
  22. Miranda, Cláudia C.; Pascoal, Jorge F.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Expansion and Neural Commitment of Human Pluripotent Stem Cells as 3D Suspension Aggregates". Paper presented in 4th International Conference on Stem Cell Engineering, 2014.
  23. Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Towards fully defined conditions for human induced pluripotent stem cell expansion". Paper presented in ", 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2011.
  24. Miranda, Cláudia C.; Martins, Célia; Doran, Carolina; Cabral, Maria Guadalupe; Dinis, Joana; Gromicho, Marta; Laires, António; et al. "Study of cell cycle, apoptosis and dna damage, in human K562 leukaemia cells: effect of the alkenylbenzene myristicin". Paper presented in 10th International Conference on Environmental Mutagens, 2009.
Journal article
  1. Branco, André; Rayabaram, Janakiram; Miranda, Cláudia C.; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Sajja, Suchitra; da Silva, Cláudia L.; Vemuri, Mohan C.. "Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications". Frontiers in Bioengineering and Biotechnology 12 (2024): https://doi.org/10.3389/fbioe.2024.1380950.
    10.3389/fbioe.2024.1380950
  2. Soares, Beatriz Xavier; Miranda, Cláudia C.; Fernandes, Tiago G.. "Systems bioengineering approaches for developmental toxicology". Computational and Structural Biotechnology Journal 21 (2023): 3272-3279. http://dx.doi.org/10.1016/j.csbj.2023.06.005.
    10.1016/j.csbj.2023.06.005
  3. Miranda, Cláudia C.; Gomes, Mariana Ramalho; Moço, Mariana; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Sanjuan-Alberte, Paola. "A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering". Bioengineering 9 10 (2022): 554. http://dx.doi.org/10.3390/bioengineering9100554.
    Published • 10.3390/bioengineering9100554
  4. Miranda, Cláudia C.; Akenhead, Michael L.; Silva, Teresa P.; Derr, Michael A.; Vemuri, Mohan C.; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "A Dynamic 3D Aggregate-Based System for the Successful Expansion and Neural Induction of Human Pluripotent Stem Cells". Frontiers in Cellular Neuroscience 16 (2022): http://dx.doi.org/10.3389/fncel.2022.838217.
    10.3389/fncel.2022.838217
  5. Jalili-Firoozinezhad, Sasan; Miranda, Cláudia C.; Cabral, Joaquim M.S.. "Modeling the Human Body on Microfluidic Chips". Trends in Biotechnology (2021): http://dx.doi.org/10.1016/j.tibtech.2021.01.004.
    10.1016/j.tibtech.2021.01.004
  6. Miranda, Cláudia C.; Barata, Tiago; Vaz, Sandra H.; Ferreira, Carla; Quintas, Alexandre; Bekman, Evguenia P.. "hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00119.
    Open access • 10.3389/fnmol.2020.00119
  7. Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors". Journal of Biological Engineering 13 1 (2019): http://dx.doi.org/10.1186/s13036-019-0204-1.
    10.1186/s13036-019-0204-1
  8. Miranda, Cláudia C.; Fernandes, Tiago G.; Pinto, Sandra N.; Prieto, Manuel; Diogo, M. Margarida; Cabral, Joaquim M.S.. "A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies". Toxicology Letters 294 (2018): 51-60. http://dx.doi.org/10.1016/j.toxlet.2018.05.018.
    10.1016/j.toxlet.2018.05.018
  9. Miranda, Cláudia; Fernandes, Tiago; Diogo, Maria; Cabral, Joaquim. "Towards Multi-Organoid Systems for Drug Screening Applications". Bioengineering 5 3 (2018): 49. http://dx.doi.org/10.3390/bioengineering5030049.
    10.3390/bioengineering5030049
  10. Badenes, S.M.; Fernandes, T.G.; Miranda, C.C.; Pusch-Klein, A.; Haupt, S.; Rodrigues, C.A.V.; Diogo, M.M.; Brüstle, O.; Cabral, J.M.S.. "Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system". Journal of Chemical Technology and Biotechnology 92 3 (2017): 492-503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990198014&partnerID=MN8TOARS.
    10.1002/jctb.5074
  11. Miranda, C.C.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells". Biotechnology Journal 11 12 (2016): 1628-1638. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003042306&partnerID=MN8TOARS.
    10.1002/biot.201600446
  12. Miranda, C.C.; Fernandes, T.G.; Pascoal, J.F.; Haupt, S.; Brüstle, O.; Cabral, J.M.S.; Diogo, M.M.. "Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment". Biotechnology Journal 10 10 (2015): 1612-1624. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943363190&partnerID=MN8TOARS.
    10.1002/biot.201400846
  13. Martins, Célia; Doran, Carolina; Silva, Inês C.; Miranda, Claudia; Rueff, José; Rodrigues, António S.. "Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells". Chemico-Biological Interactions 218 (2014): 1-9. http://dx.doi.org/10.1016/j.cbi.2014.04.014.
    10.1016/j.cbi.2014.04.014
Thesis / Dissertation
  1. Miranda, Cláudia C.. "AGGREGATE-BASED SYSTEMS FOR PRODUCTION OF NEURAL PROGENITORS FROM HUMAN PLURIPOTENT STEM CELLS". PhD, Universidade de Lisboa Instituto Superior Técnico, 2016.
  2. Miranda, Cláudia C.. "Towards Fully Defined Culture Systems for Human Induced Pluripotent Stem Cell Expansion". Master, Universidade de Lisboa Instituto Superior Técnico, 2011.
  3. Miranda, Cláudia C.. "Mecanismos de genotoxicidade e apoptose do alcenilbenzeno miristicina em linhas celulares de Leucemia Mielóide Crónica K562, sensíveis e resistentes ao fármaco Imatinib". Degree, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2009.

Intellectual property

Patent
  1. João Carreira; Domingos Henrique; Diogo, Maria Margarida; Carlos Rodrigues; Miranda, Cláudia C.. 2021. "Method for the development of stem cell lines". Portugal.
Provisional application for patent
  1. 2024. "Kidney organoids".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06/22 Pairing 3D Pluripotent Stem Cell Suspension Culture with Downstream Differentiation to Enable Efficient Generation of Large Numbers of Cells ISSCR 2021 Annual Meeting
International Society for Stem Cell Research
2021/04/15 Human Pluripotent Stem Cells as a Model for Neurodevelopmental Toxicity Gibco Cell Culture Heroes
Gibco - Thermo Fisher Scientific
2020/11 Development of a robust and scalable culture platform for expansion and neural induction of human pluripotent stem cells in suspension culture 3 Days of 3D Cell Model Virtual Event 2020
ThermoFisher Scientific
2020/10 Development of a robust and scalable culture platform for expansion and neural induction of human pluripotent stem cells in suspension culture 5 Days of Stem Cells Virtual Event 2020
ThermoFisher Scientific
2020/04 Towards multi-organoid systems for drug screening applications Introduction to Regenerative Medicine
Faculdade de Ciências Médicas - Universidade Nova de Lisboa
2020/02 Das células aos mini órgãos: aplicações das células pluripotentes humanas Jortec '20 Bioquímica
(Almada, Portugal)
2019/12/18 Towards multi-organoid systems for drug screening applications CEDOC Seminars
(Lisbon, Portugal)
2019/07/08 Towards multi-organoid systems for drug screening applications iBB Spring Seminars 2019
2019/05/08 Applications of Human Pluripotent Stem Cells towards Regenerative Medicine, Drug Discovery and Disease Modeling Tissue Regeneration Talk
Núcleo de Bioquímica - Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa
2019/03/14 Towards multi-organoid systems for drug screening applications Introdução à Medicina Regenerativa
Faculdade de Ciências Médicas - Universidade Nova de Lisboa
2018/04/23 Neural Induction of Human Pluripotent Stem Cells: Applications in Bioengineering and Drug Discovery iBB Spring Seminars 2018
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current A multidisciplinary approach to tackle the challenges posed by the new psychoactive substances (NPS): focus on emergent synthetic cathinones and cannabinoids (SC)
Co-supervisor
 Química (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/03 - 2023/12 Human Pluripotent Stem Cell-Derived Kidney Organoids for Nephrotoxicity Testing
Supervisor
 Engenharia Biológica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/12 Engineering the Formation of Vascular Networks in Human Brain Organoids
Co-supervisor
 Bioengenharia em Medicina Regenerativa e de Precisão (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - 2022/12 Generation of human pluripotent stem cell derived-kidney organoids for drug screening
Supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/11 - 2022/11/17 Modelling the prenatal exposure to synthetic cathinones
Co-supervisor
 Engenharia Biológica
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/03 - 2022/07/12 Estratégias de bioengenharia para otimização do desenvolvimento de organóides cerebelares
Co-supervisor
 Química Aplicada (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/02/15 Derivation of kidney organoids from human induced pluripotent stem cells under 3D conditions
Supervisor
 Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/09/29 - 2023/09/29 From animal models to organoids: the future of drug discovery. Presenting the advantages of organoids towards the replacement of animal models to scientists and te general public.
Exhibition
 2023 European Researchers' Night
Fundação Champalimaud, Portugal
2020/03/12 - 2020/05/28 Lab2Market@Técnico is an innovation acceleration program organized by Técnico in collaboration with Everis and i-Deals.
Workshop
 Lab2Market@Técnico
2013/04/28 - 2013/05/03 This Advanced Course brings together experts from across the field to equip students with the necessary skills so that the area regenerative medicine can grow as an industry and realise its potential to contribute to the world economy.
Workshop
 International Advanced Course on Regenerative Medicine Manufacturing
2009/08 - 2009/08 Novartis Biotechnology Leadership Camp (Biocamp) is a pioneering three-day seminar that brings the healthcare sector closer to talented students from top universities around the world.
Workshop
 Novartis European Biocamp 2009
Novartis Institutes for BioMedical Research Basel, Switzerland

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/02/21 "Identificação, Síntese e Avaliação da Citotoxicidade de Catinonas e dos seus Principais Metabolitos"
(Thesis) Arguer
 Tiago Vicente (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/12 Understanding the Neuropathological Mechanisms Underlying Niemann-Pick Disease using Cerebellar Organoids
(Thesis) Main arguer
 Daniela Cuffs (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/12 Use of cerebellar organoids to disentangle the mechanisms of divergence during the neurodevelopment of humans and non-human primates
(Thesis) Main arguer
 Maria Coelho (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/21 Comparing Vascular Morphogenesis of Human Adipose Microvascular Endothelial Cells and Human Umbilical Vein Endothelial Cells in a Microfluidic Device
(Thesis) Main arguer
 Inês Lobo Faria (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11 Modelling Axonal Degeneration for FUS-ALS
(Thesis) Main arguer
 Sara Sebastião (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/12 Molecular effects of a novel SNCA mutation associated with Parkinson’s disease
(Thesis) Main arguer
 Ana Rita Landeiro Filipe de Sousa (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/12 Effects of the novel K58N mutation on alpha-synuclein aggregation in cell models
(Thesis) Main arguer
 Gonçalo Mestre (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/12 Evaluating The Effects Of Synthetic Cannabinoids On Neuronal Development - An Organoid-Based Model For Pre-Natal Exposure
(Thesis) Main arguer
 Rita Covas (Master)
Instituto Universitário Egas Moniz, Portugal
2022/11 Influence of hypoxic conditions for on-chip co-culture of endothelial and retinal pigmented epithelial cells
(Thesis) Main arguer
 Filipa Custódio (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11 Síntese e atividade neurotóxica de metabolitos de catinonas sintéticas
(Thesis) Arguer
 Inês Lomba (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11 Characterisation of effects of SNORD87 and SNORD88 on the physiology and ageing of skin cells
(Thesis) Main arguer
 Marta Rocha (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/11/15 Studying the Effect of the ROCK Inhibitor on the Proliferation Potential of Human Induced Pluripotent Stem Cells under 2D/3D and Static/Dynamic Culture Environments
(Thesis) Main arguer
 Mafalda Gomes Pereira (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

Society Organization name Role
2021/02 - Current Organ-on-a-chip Technologies Network Academic member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09 - Current Cell and Tissue Engineering Bioengenharia em Medicina Regenerativa e de Precisão (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - Current Cell and Tissue Engineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - Current Cell and Tissue Engineering Biotecnologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - Current Cell and Tissue Engineering Microbiologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - Current Cell and Tissue Engineering Bioengenharia e Nanossistemas (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - Current Cell and Tissue Engineering Ciências de Engenharia - Engenharia Biomédica (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2018/10/17 Opinion on the development of use organoids for drug screening. Wired UK
2009/09/23 A nova experiência da Novartis chama-se Laboratório do Futuro. A perspective on the new laboratory facilities that Novartis is expected to develop. P2 - Publico

Interview (tv / radio show)

Program Topic
2023/07/03 - Current 90 Segundos de Ciência EP. 1591 CLÁUDIA MIRANDA – INVESTIGAÇÃO DESENVOLVE MINI RINS EM LABORATÓRIO PARA TESTAR A SEGURANÇA DE NOVOS FÁRMACOS

Journal scientific committee

Journal title (ISSN) Publisher
2022/01 - Current Frontiers in Tissue Engineering and Regenerative Medicine
2021/12 - Current Bioengineering MDPI
2020/04 - Current Journal of Visualized Experiments (1940-087X) MyJove Corp
2018/10 - Current OAN Biotechnology Journal Thinkershub AB
2018/08 - Current Stem Cells International (1687-9678) Hindawi Publishing Corporation (Sage-Hindawi Access to Research)

Mentoring / Tutoring

Topic Student name
2017/09 - Current Human stem cell editing by CRISPR-Cas9 to allow cell transplantation without rejection. João Carreira
2013 - Current My First Experience in the World of Work 2 students per year from Valsassina School, Lisbon
2017/02 - 2017/11 Integrated expansion and cardiac differentiation of human induced pluripotent stem cells in 2D and 3D conditions Mariana Martins Barardo dos Santos Pina
2017/02 - 2017/11 Generating dorsal spinal progenitors and neurons from embryonic stem cells. Study of the impact of manipulating BMP signalling Tiago André Campos Costa Barata
2012/09 - 2013/12 Ex-vivo expansion of human Pluripotent Stem Cells using alginate based culture systems Alice Portela
2013/03 - 2013/11 Culture Platform for Induction of Human Induced Pluripotent Stem Cells into Cortical Neural Stem and Progenitor Cells under Chemically Defined Conditions Diana Catarina Santos
2012/03 - 2012/10 Purification of Human Induced Pluripotent Stem Cell-Derived Cells for Regenerative Medicine Applications Gonçalo Morais e Castro Rodrigues
2011/09 - 2012/07 Integrated Platform for the Expansion and Neural Differentiation of Human Induced Pluripotent Stem Cells Andreia Filipa Silva de Matos
Distinctions

Award

2024 Colgate-Palmolive Grant for Alternative Research
Society of Toxicology, United States
2021 Gibco Cell Culture Hero April 2021

Other distinction

2020 Lab2Market@Técnico - member of selected team
2011 PhD Grant (SFRH/BD/78758/2011 )
2009 Selected for Novartis Biotechnology Leadership Camp 2009
Novartis Institutes for BioMedical Research Basel, Switzerland