NUNO MIGUEL DA SILVA EMPADINHAS (C511-C024-BE7A)

Curriculum Vitae

NUNO MIGUEL DA SILVA EMPADINHAS

Nuno Empadinhas holds a degree in Biology and a PhD in Biochemistry with specialization in Microbiology from the University of Coimbra (UC) (advisors Milton S. da Costa (UC), and Helena Santos (ITQB-NOVA). Principal Investigator at Center for Neuroscience and Cell Biology (CNC) (CIBB - Centre for Innovative Biomedicine and Biotechnology). Coordinator of the PhD Programme in Experimental Biology and Biomedicine (PDBEB) since 2024. His research focuses on the biology of nontuberculous mycobacteria (NTM) found in drinking water systems, which can cause severe chronic infections. His work also explores the gut microbiome’s role in neurodegeneration, focusing on microbial neurotoxins biosynthesis. His research in Parkinson's Disease models uncovered a toxic pathway from chronic ingestion of the microbial toxin BMAA via aquatic foods, exposing populations to unmonitored health risks. As a molecular microbiologist, he deciphered molecular mechanisms of microbial adaptation to extreme environments and several biosynthetic pathways for glycosidic compatible solutes in extremophiles. He has elucidated key steps in the biosynthesis of polymethylated polysaccharides in M. tuberculosis and NTM. Identified genes and enzymes that were founders of 17 new families in the IUBMB database (https://www.enzyme-database.org/query.php?name=Empadinhas). Co-authored >90 publications (e.g. PNAS, Gut Microbes, Gut, Mol Microbiol, Nat Prod Rep, mBio, Commun Biol, J Bacteriol, J Biol Chem; 6 book chapters; 2 international patents). He has served on various grant evaluation committees (e.g. Agence Nationale de la Recherche, MSCA Cofund REWIRE, ERA-NET NEURON, Hong Kong Health Medical Research Fund, Fundação para a Ciência e a Tecnologia (FCT), and has served as peer-reviewer for over 25 journals. Invited speaker at over 50 scientific meetings. Supervised or co-supervised 14 PhD students, 14 MSc students, and 5 postdoctoral fellows. His transdisciplinary microbiology research has atracted over €2 million in funding from different agencies and organizations (e.g. FCT, Santa Casa da Misericórdia de Lisboa, Infarmed, Mizutani Foundation for Glycoscience, Pfizer). He has recently been elected President of the Carbohydrate Group of the Portuguese Chemical Society (SPQ) (2025-2027). His scientific contributions have been recognized with several awards, including the Mizutani Glycoscience Grant (2012), making him the first Portuguese to receive this honor since its inception in 1993. Other honors include the Mantero Belard Award (2016), the Thomé Villar Award (2017), the UC Seed Project Award (2020), and the Pfizer Award in Basic Research (2023).

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Identification

Personal identification

Full name: NUNO MIGUEL DA SILVA EMPADINHAS

Citation names

Empadinhas, Nuno

Author identifiers

Ciência ID: C511-C024-BE7A
ORCID iD: 0000-0001-8938-7560
Google Scholar ID: https://scholar.google.com/citations?hl=en&user=-jHQdEgAAAAJ&view_op=list_works
Researcher Id: AAC-6157-2019
Scopus Author Id: 6602504934

Email addresses

nuno.empadinhas@uc.pt (Professional)
numenius@cnc.uc.pt (Professional)
nempadinhas@gmail.com (Personal)

Telephones

Telephone

(+351) 304502931 (Professional)
(+351) 239820190 Ext.: 140 (Professional)

Addresses

Centro de Neurociências e Biologia Celular (CNC), Rua Larga, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

https://www.cnc.uc.pt/en/research-group/molecular-mycobacteriology-and-microbiome (Professional)
https://www.cibb.uc.pt/en/research-group/molecular-mycobacteriology-and-microbiome (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Microbiology
Natural sciences - Biological Sciences - Molecular Biology
Medical and Health Sciences - Health Sciences - Infectious Diseases

Education

	Degree	Classification
2000 - 2004 Concluded	Bioquímica (Doutoramento) Major in Specialty in Microbiology Universidade de Coimbra, Portugal "Pathways for the synthesis of mannosylglycerate in prokaryotes. Genes, enzymes and evolutionary implications" (THESIS/DISSERTATION)	Distinction and Honours
1997 - 1999 Concluded	Biologia Celular (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	Very Good
1990 - 1996 Concluded	Biologia (Licenciatura) Major in Microbiologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR" (THESIS/DISSERTATION)	Good (14/20)
1986 - 1989 Concluded	Quimicotecnia (Ensino secundário) Escola Secundária André de Gouveia, Portugal

Affiliation

Science

	Category Host institution	Employer
2024 - Current	Principal Investigator (Research)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

2019 - 2023	Principal Investigator (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2008 - 2018	Auxiliary Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998 - 2004	Visiting Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2008 - 2011	Invited Assistant Professor (University Teacher)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

	Category Host institution	Employer
2025/09 - 2027/09	President - Carbohydrates Group	Sociedade Portuguesa de Química, Portugal
	Sociedade Portuguesa de Química, Portugal
2024/06 - 2027/05	Coordinator - PhD Programme in Experimental Biology and Biomedicine	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2021 - 2024	Advanced Studies and Career Development Office (Member)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Others

	Category Host institution	Employer
2024/06 - 2027/05	Coordinator - Advanced Studies and Career Development Office	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Projects

Contract

	Designation	Funders
2025 - 2028	WATERGATE: Drinking water microbiota with implications for chronic diseases MPr-2023-12 - 15665 Principal investigator Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2023 - 2026	Validation of bacterial-derived anti-inflammatory mediators in gut-first PD CP code: SC01 Researcher Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Cure Parkinson's UK Ongoing
2023 - 2025	AMRFIGHT - Exploring bacterial interactions to find novel molecules to combat the antimicrobial resistance catastrophe 2022.06809.PTDC Researcher Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022 - 2025	NTMENACE - Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic PTDC/BIA-MIC/0122/2021 Principal investigator Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Administração Regional de Saúde do Centro IP, Portugal Universidade do Porto Instituto de Saúde Pública, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022 - 2023	Microbiome-miRNAs axis in Parkinsons disease: involvement of mitochondrial mediated inflammatory response EXPL/MED-NEU/1515/2021 Researcher Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021 - 2023	The Gut-Immune-Brain Axis in Parkinson disease PTDC/MED-NEU/3644/2020 Co-Principal Investigator (Co-PI) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	Green method to prepare sterilized biopolymers based aerogel PTDC/EQU-EPQ/32625/2017 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06/15 - 2021/12/31	POLYREP - An intriguing mycobacterial polysaccharide: recycling, replication and beyond PTDC/BTM-TEC/29221/2017 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020 - 2021	Sustainable and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system Prémio Projetos Semente de I&D "Era pós-COVID 19: uma sociedade mais sustentável, resiliente e justa Researcher Universidade de Coimbra, Portugal	Universidade de Coimbra/Santander Concluded
2017 - 2021	HealthyAging2020 (WP9 - Deciphering microbiome signatures in chronic diseases for early diagnosis and modulation therapies) (Institutional-HR) CENTRO-01-0145-FEDER-000012-N2323 Researcher Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal CNC.IBILI, Portugal	European Regional Development Fund Comissão de Coordenação e Desenvolvimento Regional do Centro Concluded
2017 - 2020	The toxinogenic gut microbiome in sporadic Parkinson's Disease: a quest for "antiPDbiotics" Mantero Belard Prize 2016 - MB-40-2016 Co-Principal Investigator (Co-PI) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Santa Casa da Misericórdia de Lisboa Concluded
2018 - 2018	Prevalência de micobactérias não-tuberculosas em ambiente doméstico Prémio Thomé Villar/Boehringer Ingelheim 2017 Co-Principal Investigator (Co-PI) Universidade do Porto Instituto de Saúde Pública, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Sociedade Portuguesa de Pneumologia Boehringer Ingelheim Portugal Concluded
2016 - 2018	MICROCARE - Microbiome of diabetic ulcers: early diagnosis, prognosis and therapy FIS-2015-01_DIA_20150630-144 Co-Principal Investigator (Co-PI) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal CNC.IBILI, Portugal	Infarmed - Fundo para a Investigação em Saúde Concluded
2016 - 2016	The impairment of neuronal metabolism by gut microbiome effectors FMUC-BST-2016-221 Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Faculdade de Medicina, Universidade de Coimbra & Banco Santander Concluded
2014 - 2015	Produção e comercialização global de compostos microbianos para investigação InovC 2014 Principal investigator Universidade de Coimbra, Portugal	European Regional Development Fund Concluded
2013 - 2015	Biosynthesis of rare methylmannose polysaccharides in nontuberculous mycobacteria PTDC/BIA-MIC/2779/2012 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2015	Ambiguity and virulence in a human pathogen PTDC/BBB-BEP/0695/2012 Researcher Instituto de Biologia Molecular e Celular, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2014	Unravelling the early steps in the biosynthesis of the mycobacterial MGLP Grant 120123 Principal investigator Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal	Mizutani Foundation for Glycoscience Concluded
2011 - 2014	Pathway for the synthesis of the mycobacterial MGLP. Biochemical and structural characterization of the key enzymes PTDC/BIA-PRO/110523/2009 Principal investigator Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2013	The enigmatic mycobacterial maltokinase PTDC/BIA-BCM/112459/2009 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2010	Characterization and evolution of a rare glycosyltransferase from the antitumor producing bacteria of the genus Actinosynnema Acordo Cultural 2010 Eslováquia 124626903612592 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Cloning, expression and regulation of genes for the synthesis of compatible solutes in Thermus thermophilus Acção Nº E-9/08 Researcher Universidade de Coimbra, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal	Conselho de Reitores das Universidades Portuguesas, Portugal Concluded
2005 - 2008	Compatible solutes from extremophiles: screening, biosynthesis and heterologous production POCI/V.5/A0005/2005 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp. POCI/BIA-MIC/56511/2004 Researcher Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004 - 2006	Hotsolutes: New applications for compatible solutes from Extremophiles COOP-CT-2003-508644 Post-doc Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal	European Commission Concluded
2002 - 2004	Hypersolutes: Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes QLK3-CT-2000-00640 PhD Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Commission Concluded
2001 - 2004	Towards the Utilization of Cell-Reactors for the Production of Mannosylglycerate, an Enzyme Stabilizer from Hyperthermophiles POCTI/BIO/35715/1999 PhD Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1997 - 1999	Extremophiles as cell factories BIO4960488 Master Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	European Commission Concluded

Other

	Designation	Funders
2025 - 2029	CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional) UID/04539/2023 Researcher Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021 - 2025	DYNABrain - Dynamic Brain Function: Towards the Understanding and Treatment of Brain Disorders (ERA Chairs - Institutional) H2020-WIDESPREAD-2018-2020-6, ID: 952422 WIDESPREAD-06-2020 - ERA Chairs Other Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Commission Ongoing
2021 - 2025	CIBB - Center for Innovative Biomedicine and Biotechnology - Associate Laboratory (Institutional) LA/P/0058/2020 10.54499/LA/P/0058/2020 Researcher Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - 2023	CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional) UIDB/04539/2020 and UIDP/04539/2020 Researcher Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Book chapter	Maranha A, Empadinhas N. "Mycobacterial pathways from simple glycosides to fatty acid sheltering polymethylated polysaccharides". United Kingdom: Royal Society of Chemistry, 2025. In press Emanuel Candeias, Daniela Nunes-Costa, A. Raquel Pereira-Santos, João D. Magalhães, Inês Melo-Marques, Betariz Guedes, A; Nuno Empadinhas, Sandra M. Cardoso. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". In Natural Molecules in Neuroprotection and Neurotoxicity, edited by Marcos Oliveira, 747-778. United States: Elsevier Inc., 2024. Published • 10.1016/b978-0-443-23763-8.00068-3 Nuno Empadinhas. "Cerveja de precisão e saúde: do intestino ao cérebro". In A Cerveja - Património de Coimbra e do Mundo, edited by coord. Carla Barbosa & Pedro Baptista; Almedina & Praxis. Coimbra, Portugal: Almedina, 2023. Published Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa". In A Saúde no Saber - Um Projeto de Promoção da Literacia em Saúde, edited by Maria João Padez de Castro. Coimbra, Portugal: Imprensa da Universidade de Coimbra, 2023. Published Costa J, Empadinhas N, Alarico S, Nobre A, Albuquerque L, da Costa MS. "The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments". In Marine Enzymes for Biocatalysis, 465-502. Elsevier, 2013. Published • 10.1533/9781908818355.3.465 da Costa MS, Empadinhas N. "Biosynthesis of the Compatible Solute Mannosylglycerate from Hyperthermophiles to Mesophiles". In Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya, 311-325. Springer Netherlands, 2005. Published • 10.1007/1-4020-3633-7_21 Empadinhas N, Silva Z, da Costa MS. "Os solutos compatíveis como estratégia de sobrevivência a agressão osmótica". In Biotecnologia - Fundamentos e Aplicações (ISBN: 978-972-757-197-0), edited by Nelson Lima, Manuel Mota, 51-67. Portugal: Lidel, 2003. Published
Journal article	Abreu AE, Empadinhas N, Cardoso SM. "Unveiling butyrate as a Parkinson's disease therapy". Neuroscience Bulletin (2025): https://doi.org/10.1007/s12264-025-01498-x. In press Bento CSA, Lopes DL, Villarreal CF, Empadinhas N, Alarico S, de Sousa HC, Braga MEM. "Shelf-life of sterilised alginate-gelatine aerogels developed through an integrated high-pressure and supercritical CO2 process". The Journal of Supercritical Fluids 228 (2025): 106781. https://doi.org/10.1016/j.supflu.2025.106781. Published • 10.1016/j.supflu.2025.106781 Bento CSA, Ruivo JP, Alarico S, Empadinhas N, Candeias, Cardoso SM, de Sousa HC, Dias AMA, Braga MEM. "Eco-friendly development of sterile chitosan-based aerogels for wound dressing applications using integrated scCO2 processing". International Journal of Pharmaceuticals (2025): Published Roxo IC, Alarico S, Fonseca A, Machado D, Maranha A, Tiago I, Duarte R, Empadinhas N. "Mycobacterium appelbergii sp. nov., a novel species Isolated from a drinking water fountain in a rural community". Microorganisms 3 (2025): https://www.mdpi.com/2076-2607/13/6/1259. Published • 10.3390/ microorganisms13061259 Matos GA, Nunes-Costa D, Pinto DV, Martins CS, Silva JL, Leocadio PCL, Andrade MER, Raposo RS, Tiago I, Alarico S, Santo; Cardoso VN, Santos FA, Alvarez-Leite JI, Empadinhas N, Oriá RB. "Methylmercury chronic exposure and a high-fat diet induce gut microbiome alterations and intestinal barrier disruption in mice". Environmental Toxicology (2025): http://doi.org/10.1002/tox.24469. Published • 10.1002/tox.24469 Sobral J, Empadinhas N, Esteves AR, Cardoso SM. "Impact of nutrition on gut microbiota: Implications for Parkinson’s Disease". Nutrition Reviews (2025): https://doi.org/10.1093/nutrit/nuae208. Published Munoz-Pinto MF, Candeias E, Melo-Marques I, Esteves AR, Maranha A, Magalhães JD, Carneiro DR, Sant'Anna M; Pereira-Santos AR, Abreu AE, Nunes-Costa D, Alarico S, Tiago I, Morgadinho A, Lemos J, Figueiredo PN, Januário C; Empadinhas N, Cardoso SM. "Gut-first Parkinson's disease is encoded by gut dysbiome". Molecular Neurodegeneration 19 (2024): https://doi.org/10.1186/s13024-024-00766-0. Published • https://doi.org/10.1186/s13024-024-00766-0 Bento C, Lopes D, Villarreal C, Empadinhas N, Alarico S, de Sousa HC, Braga MEM. "Integrated processes (HPSE+scCO2) to prepare sterilized alginate-gelatine-based aerogel". International Journal of Pharmaceutics 662 (2024): 124546. http://dx.doi.org/10.1016/j.ijpharm.2024.124546. Published • 10.1016/j.ijpharm.2024.124546 Melo-Marques I, Cardoso SM, Empadinhas N. "Bacterial extracellular vesicles at the interface of gut microbiota and immunity". Gut Microbes 16 1 (2024): https://doi.org/10.1080/19490976.2024.2396494. Published • 10.1080/19490976.2024.2396494 Antoniuk O, Maranha A, Salvador J, Empadinhas N, Moreira V. "Bi- and tricyclic diterpenoids: landmarks from a decade (2013–2023) in search of leads against infectious diseases". Natural Product Reports (2024): http://dx.doi.org/10.1039/d4np00021h. Published • 10.1039/d4np00021h Maranha A, Alarico S, Nunes-Costa D, Melo-Marques I, Roxo I, Castanheira P, Caramelo O, Empadinhas N. "Drinking water microbiota, entero-mammary pathways, and breast cancer: Focus on nontuberculous mycobacteria". Microorganisms 12 7 (2024): 1425. http://dx.doi.org/10.3390/microorganisms12071425. Published • 10.3390/microorganisms12071425 Candeias E, Pereira-Santos AR, Empadinhas N, Cardoso SM, Esteves AR. "The Gut-Brain Axis in Alzheimer’s and Parkinson’s Diseases: The Catalytic Role of Mitochondria". Journal of Alzheimer's Disease (2024): 1-17. http://dx.doi.org/10.3233/jad-240524. Published • 10.3233/jad-240524 Pereira-Santos AR, Candeias E, Magalhães JD, Empadinhas N, Esteves AR, Cardoso SM. "Neuronal control of microglia through the mitochondria". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024): 167167. http://dx.doi.org/10.1016/j.bbadis.2024.167167. Published • 10.1016/j.bbadis.2024.167167 Magalhães JD, Candeias E, Melo-Marques I, Abreu AE, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease". International Journal of Molecular Sciences 25 6 (2024): 3423. https://www.mdpi.com/1422-0067/25/6/3423. Published • 10.3390/ijms25063423 Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. "Gut-brain-axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine". Veterinary Medicine International 2024 2856759 (2024): https://doi.org/10.1155/2024/2856759. Published • 10.1155/2024/2856759 Bento CSA, Carrelo H, Alarico S, Empadinhas N, de Sousa HC, Cidade MT, Braga MEM. "Effect of ScCO2 on the decontamination of PECs-based cryogels: a comparison with H2O steam and H2O2 nebulization methods". International Journal of Pharmaceutics (2023): 123451. http://dx.doi.org/10.1016/j.ijpharm.2023.123451. Published • 10.1016/j.ijpharm.2023.123451 Coimbra P, Alarico S, Empadinhas N, Braga MEM, Gaspar MC. "Sustainable starch-based edible films with agrifood residues as potential carriers for the probiotic Lactobacillus rhamnosus". Innovative Food Science & Emerging Technologies 88 (2023): 103452. http://dx.doi.org/10.1016/j.ifset.2023.103452. Published • 10.1016/j.ifset.2023.103452 Magalhães JD, Candeias E, Melo-Marques I, Silva DF, Esteves AR, Empadinhas N, Cardoso SM. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinsons disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3. Published • 10.1007/s00018-023-04819-3 Magalhães JD, Esteves AR, Candeias E, Silva DF, Empadinhas N, Cardoso SM. "The role of bacteria-mitochondria communication in the activation of neuronal innate immunity: Implications to Parkinson's Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339. Published • 10.3390/ijms24054339 Maranha A, Costa M, Ripoll-Rozada J, Manso JA, Miranda V, Mendes V, Manadas B, Macedo-Ribeiro S, Ventura MR; Pereira PJB, Empadinhas N. "Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides". Communications Biology 6 1 (2023): 108. https://doi.org/10.1038/s42003-023-04448-3. Published • 10.1038/s42003-023-04448-3 Esteves AR, Muñoz-Pinto MF, Nunes-Costa D, Candeias E, Silva DF, Magalhães JD, Pereira-Santos AR, Ferreira IL; Alarico S, Tiago I, Empadinhas N, Cardoso SM. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut 72 1 (2023): 73-89. http://dx.doi.org/10.1136/gutjnl-2021-326023. Published • 10.1136/gutjnl-2021-326023 Costa HN, Esteves AR, Empadinhas N, Cardoso SM. "Parkinson's Disease: a multisystem disorder". Neuroscience Bulletin 39 1 (2023): 113-124. http://dx.doi.org/10.1007/s12264-022-00934-6. Published • 10.1007/s12264-022-00934-6 Silva DF, Empadinhas N, Cardoso SM, Esteves AR. "Neurodegenerative microbially-shaped diseases: oxidative stress meets neuroinflammation". Antioxidants 11 11 (2022): 2141. http://dx.doi.org/10.3390/antiox11112141. Published • 10.3390/antiox11112141 Bento C, Alarico S, Empadinhas N, Sousa HC, Braga MEM. "Sequential scCO2 drying and sterilisation of alginate-gelatine aerogels for biomedical applications". The Journal of Supercritical Fluids 184 (2022): 105570. http://dx.doi.org/10.1016/j.supflu.2022.105570. Published • 10.1016/j.supflu.2022.105570 Gonçalves S, Nunes-Costa D, Cardoso SM, Empadinhas N, Marugg JD. "Enzyme promiscuity in serotonin biosynthesis, from bacteria to plants and humans". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.873555. Published • 10.3389/fmicb.2022.873555 Muñoz-Pinto MF, Empadinhas N, Cardoso SM. "The neuromicrobiology of Parkinson's disease: A unifying theory". Ageing Research Reviews 70 (2021): 101396. http://dx.doi.org/10.1016/j.arr.2021.101396. Published • 10.1016/j.arr.2021.101396 Gonçalves AM, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "The Mitochondrial Ribosome: A world of opportunities for mitochondrial dysfunction toward Parkinson's Disease". Antioxidants & Redox Signaling 34 8 (2021): 694-711. https://www.liebertpub.com/doi/10.1089/ars.2019.7997. Published • 10.1089/ars.2019.7997 Mouritzen MV, Petkovic M, Qvist K, Poulsen SS, Alarico S, Leal EC, Dalgaard LT, Empadinhas N, Carvalho E, Jenssen H. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy - Methods & Clinical Development 20 (2021): 726-739. https://doi.org/10.1016/j.omtm.2021.02.008. Published • 10.1016/j.omtm.2021.02.008 Silva DF, Candeias E, Esteves AR, Magalhães JD, Ferreira IL, Nunes-Costa D, Rego AC, Empadinhas N, Cardoso SM. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation and Alzheimer's disease features in cortical neurons". Journal of Neuroinflammation 17 332 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y. Published • 10.1186/s12974-020-02004-y Oriá RB, Empadinhas N, Malva JO. "Editorial: Interplay between nutrition, the intestinal microbiota and the immune system". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.01758. Published • 10.3389/fimmu.2020.01758 Alarico S, Nunes-Costa D, Silva A, Costa M, Macedo-Ribeiro S, Empadinhas N. "A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures". Microbiology 166 5 (2020): 474-483. http://dx.doi.org/10.1099/mic.0.000898. Published • 10.1099/mic.0.000898 Silva MB, Lepzienj R, Ols S, Dahlbergh B, Grunewaldh J, Lore K, Smed-Sörensen A, Correia-Neves M, Empadinhas N; Färnert A, Källenius G, Sundling C. "Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers". Journal of Immunological Methods 481 (2020): 112792. http://dx.doi.org/10.1016/j.jim.2020.112792. Published • 10.1016/j.jim.2020.112792 Nunes-Costa D, Magalhães JD, G-Fernandes M, Cardoso SM, Empadinhas N. "Microbial BMAA and the pathway for Parkinson's Disease neurodegeneration". Frontiers in Aging Neuroscience 12 (2020): https://doi.org/10.3389/fnagi.2020.00026. Published • 10.3389/fnagi.2020.00026 Cereija TB, Alarico S, Lourenço EC, Manso JA, Ventura MR, Empadinhas N, Macedo-Ribeiro S, Pereira PJB. "The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation". IUCrJ 6 4 (2019): 572-585. https://doi.org/10.1107/S2052252519005372. Published • 10.1107/S2052252519005372 Tiago I, Alarico S, Maranha A, Coelho C, Pereira SG, Empadinhas N. "High-Quality draft genome sequences of rare nontuberculous mycobacteria isolated from surfaces of a hospital". Microbiology Resource Announcements 8 21 (2019): https://doi.org/10.1128/MRA.00496-19. Published • 10.1128/MRA.00496-19 Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB. "Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity". mBio (2019): https://doi.org/10.1128/mBio.00239-19. Published • 10.1128/mBio.00239-19 Pereira SG, Alarico S, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Maranha A, Empadinhas N. "Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment". BMC Microbiology 19 1 (2019): http://dx.doi.org/10.1186/s12866-019-1428-4. Published • 10.1186/s12866-019-1428-4 Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S,; Pereira PJB; Empadinhas N. "Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides". Proceedings of the National Academy of Sciences (2019): 201813450-201813450. https://www.pnas.org/content/116/3/835.long. Published • 10.1073/pnas.1813450116 Cardoso SM, Empadinhas N. "The microbiome-mitochondria dance in prodromal Parkinson's Disease". Frontiers in Physiology 9 (2018): https://www.frontiersin.org/articles/10.3389/fphys.2018.00471/full. Published • 10.3389/fphys.2018.00471 Cereija TB, Alarico S, Empadinhas N, Pereira PJB. "Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase". Acta Crystallographica Section F Structural Biology Communications 73 9 (2017): 536-540. https://doi.org/10.1107%2Fs2053230x17012419. Published • 10.1107/S2053230X17012419 Pereira SG, Moura J, Carvalho E, Empadinhas N. "Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies". Frontiers in Microbiology 8 (2017): https://doi.org/10.3389%2Ffmicb.2017.01791. Published • 10.3389/fmicb.2017.01791 Farias PG, Gama FJ, Reis D, Alarico S, Empadinhas N, Martins JC, Almeida AF, Morais PV. "Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria". Antonie van Leeuwenhoek 110 7 (2017): 863-876. http://dx.doi.org/10.1007/s10482-017-0857-z. Published • 10.1007/s10482-017-0857-z Nunes-Costa D, Maranha A, Costa M, Alarico S, Empadinhas N. "Glucosylglycerate metabolism, bioversatility and mycobacterial survival". Glycobiology 27 (2016): 213-227. http://dx.doi.org/10.1093/glycob/cww132. Published • 10.1093/glycob/cww132 Nunes-Costa D, Alarico S, Dalcolmo MP, Correia-Neves M, Empadinhas N. "The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil". Tuberculosis 96 (2016): 107-119. http://dx.doi.org/10.1016/j.tube.2015.09.006. Published • 10.1016/j.tube.2015.09.006 Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL. "Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep17144. Published • 10.1038/srep17144 Maranha A, Moynihan PJ, Miranda V, Lourenço EC, Nunes-Costa D, Fraga JS, Pereira PJB, Macedo-Ribeiro S, Ventura MR; Clarke AJ, Empadinhas N. "Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13610. Published • 10.1038/srep13610 Fraga JS, Maranha A, Mendes V, Pereira PJB, Empadinhas N, Macedo-Ribeiro S. "Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway". Scientific Reports 5 (2015): https://doi.org/10.1038/srep08026. Published • 10.1038/srep08026 Alarico S, Costa M, Sousa MS, Maranha A, Lourenço EC, Faria TQ, Ventura MR, Empadinhas N. "Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate". Scientific Reports 4 1 (2014): http://dx.doi.org/10.1038/srep06766. Published • 10.1038/srep06766 Bento CF, Empadinhas N, Mendes N. "Autophagy in the fight against tuberculosis". DNA and Cell Biology 34 4 (2014): 228-242. https://doi.org/10.1089/dna.2014.2745. Published • 10.1089/dna.2014.2745 Nobre A, Alarico S, Maranha A, Mendes V, Empadinhas N. "The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies". Microbiology (United Kingdom) 160 PART 8 (2014): 1547-1570. https://doi.org/10.1099/mic.0.075895-0. Published • 10.1099/mic.0.075895-0 Alarico S, Empadinhas N, da Costa MS. "A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1,2)-D-glycerate and alpha-D-glucopyranosyl-(1,2)-D-glycerate". Enzyme and Microbial Technology 52 2 (2013): 77-83. http://dx.doi.org/10.1016/j.enzmictec.2012.10.008. Published • 10.1016/j.enzmictec.2012.10.008 Nobre A, Empadinhas N, Nobre MF, Lourenço EC, Maycock C, Ventura MR, Mingote A, da Costa MS. "The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate". Planta 237 3 (2013): 891-901. https://doi.org/10.1007/s00425-012-1808-6. Published • 10.1007/s00425-012-1808-6 Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJB, Empadinhas N. "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins". Journal of Bacteriology 194 24 (2012): 7010-7011. DOI: https://doi.org/10.1128/JB.01880-12. Published • 10.1128/JB.01880-12 Mendes V, Maranha A, Alarico S, Empadinhas N. "Biosynthesis of mycobacterial methylglucose lipopolysaccharides". Natural Product Reports 29 8 (2012): 834-844. https://doi.org/10.1039/C2NP20014G. Published • 10.1039/c2np20014g Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N. "Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis". Scientific Reports 1 1 (2011): http://dx.doi.org/10.1038/srep00177. Published • 10.1038/srep00177 Empadinhas N, Pereira PJB, Albuquerque L, Costa J, Sá-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS. "Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity". Molecular Microbiology 79 1 (2011): 76-93. https://doi.org/10.1111/j.1365-2958.2010.07432.x. Published • 10.1111/j.1365-2958.2010.07432.x Empadinhas N, da Costa MS. "Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea". Environmental Microbiology 13 8 (2011): 2056-2077. https://doi.org/10.1111/j.1462-2920.2010.02390.x. Published • 10.1111/j.1462-2920.2010.02390.x Fernandes C, Mendes V, Costa J, Empadinhas N, Jorge C, Lamosa P, Santos H, da Costa MS. "Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis". Journal of Bacteriology 192 6 (2010): 1624-1633. https://doi.org/10.1128/JB.01424-09. Published • 10.1128/JB.01424-09 Mendes V, Maranha A, Lamosa P, da Costa MS, Empadinhas N. "Biochemical characterization of the maltokinase from Mycobacterium bovis BCG". BMC Biochemistry (2010): https://doi.org/10.1186/1471-2091-11-21. Published • 10.1186/1471-2091-11-21 Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS. "A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT". Journal of Bacteriology 190 24 (2008): 7939-7946. http://dx.doi.org/10.1128/jb.01055-08. Published • 10.1128/jb.01055-08 Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS. "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". FEMS Microbiology Letters 280 2 (2008): 195-202. https://doi.org/10.1111/j.1574-6968.2007.01064.x. Published • 10.1111/j.1574-6968.2007.01064.x Sá-Moura B, Albuquerque L, Empadinhas N, da Costa MS, Pereira PJB, Macedo-Ribeiro S. "Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 8 (2008): 760-763. https://doi.org/10.1107/S1744309108021490. Published • 10.1107/S1744309108021490 Empadinhas N, da Costa MS. "To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerate". Systematic and Applied Microbiology 31 3 (2008): 159-168. https://doi.org/10.1016/j.syapm.2008.05.002. Published • 10.1016/j.syapm.2008.05.002 Empadinhas N, da Costa MS. "Osmoadaptation mechanisms in prokaryotes: Distribution of compatible solutes". International Microbiology 11 3 (2008): 151-161. https://europepmc.org/article/med/18843593. Published • 10.2436/20.1501.01.55 Pereira PJB, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S. "Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: Structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis". PLoS ONE 3 11 (2008): https://doi.org/10.1371/journal.pone.0003748. Published • 10.1371/journal.pone.0003748 Alarico S, da Costa MS, Empadinhas N. "Molecular and physiological role of the trehalose-hydrolyzing a-glucosidase from Thermus thermophilus HB27". Journal of Bacteriology 190 7 (2008): 2298-2305. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549086172&partnerID=MN8TOARS. Published • 10.1128/JB.01794-07 Fernandes C, Empadinhas N, da Costa MS. "Single-step pathway for synthesis of glucosylglycerate in Persephonella marina". Journal of Bacteriology 189 11 (2007): 4014-4019. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249786874&partnerID=MN8TOARS. Published • 10.1128/JB.00075-07 Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, da Costa MS. "Organic solutes in Rubrobacter xylanophilus: The first example of di-myo-inositol-phosphate in a thermophile". Extremophiles 11 5 (2007): 667-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548303944&partnerID=MN8TOARS. Published • 10.1007/s00792-007-0084-z Alarico S, Empadinhas N, Mingote A, Simões C, Santos MS, da Costa MS. "Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1". Extremophiles 11 6 (2007): 833-840. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748948644&partnerID=MN8TOARS. Published • 10.1007/s00792-007-0106-x Costa J, Empadinhas N, da Costa MS. "Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: Characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina". Journal of Bacteriology 189 5 (2007): 1648-1654. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947366922&partnerID=MN8TOARS. Published • 10.1128/JB.00841-06 Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura MR, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H. "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS. Published • 10.1128/JB.00465-07 Empadinhas N, da Costa MS. "Diversity and biosynthesis of compatible solutes in hyper/thermophiles". International Microbiology 9 3 (2006): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750584278&partnerID=MN8TOARS. Published Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS. "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology 188 3 (2006): 1022-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-31344453995&partnerID=MN8TOARS. Published • 10.1128/JB.188.3.1022-1030.2006 Pires AL, Albuquerque L, Tiago I, Nobre MF, Empadinhas N, Veríssimo A, da Costa MS. "Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species". FEMS Microbiology Letters 245 1 (2005): 39-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744405109&partnerID=MN8TOARS. Published • 10.1016/j.femsle.2005.02.011 Alarico S, Empadinhas N, Simões C, Silva Z, Henne A, Mingote A, Santos H, da Costa MS. "Distribution of genes for synthesis of trehalose and mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance". Applied and Environmental Microbiology 71 5 (2005): 2460-2466. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382346&partnerID=MN8TOARS. Published • 10.1128/AEM.71.5.2460-2466.2005 Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. "Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus". Journal of Biological Chemistry 279 11 (2004): 9892-9898. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS. Published • 10.1074/jbc.M312186200 Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MAS, Santos H, da Costa MS. "A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase". Journal of Bacteriology 186 13 (2004): 4075-4084. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042523198&partnerID=MN8TOARS. Published • 10.1128/JB.186.13.4075-4084.2004 Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS. "The bacterium Thermus thermophilus, like hyperthermophilic Archaea, uses a two-step pathway for the synthesis of mannosylglycerate". Applied and Environmental Microbiology 69 6 (2003): 3272-3279. http://dx.doi.org/10.1128/aem.69.6.3272-3279.2003. Published • 10.1128/aem.69.6.3272-3279.2003 Santos P, Pinhal I, Rainey FA, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A, da Costa MS. "Gamma-Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media". Applied and Environmental Microbiology 69 11 (2003): 6533-6540. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242573382&partnerID=MN8TOARS. Published • 10.1128/AEM.69.11.6533-6540.2003 Alarico S, Rainey FA, Empadinhas N, Schumann P, Nobre MF, da Costa MS. "Rubritepida flocculans gen. nov., sp. nov., a new slightly thermophilic member of the a-1 subclass of the Proteobacteria". Systematic and Applied Microbiology 25 2 (2002): 198-206. http://dx.doi.org/10.1078/0723-2020-00116. Published • 10.1078/0723-2020-00116 Albuquerque L, Santos J, Travassos P, Nobre MF, Rainey FA, Wait R, Empadinhas N, Silva MT, da Costa MS. "Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum". Applied and Environmental Microbiology 68 9 (2002): 4266-4273. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036729238&partnerID=MN8TOARS. Published • 10.1128/AEM.68.9.4266-4273.2002 Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes". Journal of Biological Chemistry 276 47 (2001): 43580-43588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS. Published • 10.1074/jbc.M108054200 Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H. "Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase". Journal of Biological Chemistry 274 50 (1999): 35407-35414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033544948&partnerID=MN8TOARS. Published • 10.1074/jbc.274.50.35407
Magazine article	Sandra M. Cardoso, Nuno Empadinhas. "O papel do eixo microbioma-intestino-cérebro em doenças neurodegenerativas", Cidade Solidária, 2017 Nuno Empadinhas. "Fundação Mizutani, no Japão, apoia investigação inovadora realizada em Portugal", Sociedade Portuguesa de Microbiologia, 2012, https://spmicrobiologia.wordpress.com/2012/08/01/fundacao-mizutani-no-japao-apoia-investigacao-inovadora-realizada-em-portugal/.
Newspaper article	Nuno Empadinhas. "Microbiologia: uma teoria de tudo para a Vida na Terra", Diário de Notícias, 2024, https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/. Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa", Público, 2021, https://www.publico.pt/2021/10/20/ciencia/noticia/micobacterias-agua-ameaca-silenciosa-1981724. Nuno Empadinhas. "A Resistência a Antibióticos num Planeta de Micróbios e o Alerta da OMS", Diário de Coimbra, 2014
Thesis / Dissertation	Empadinhas, Nuno. "Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implications". PhD, Universidade de Coimbra, 2005. https://estudogeral.sib.uc.pt/handle/10316/1996. Empadinhas, Nuno. "A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1996.

Artistic / Performance

Visual artwork

Voyages in Tuberculosis (2019) André Caetano (Art); Nuno Empadinhas & João Ramalho-Santos (Text);. João Ramalho-Santos & Sara Amaral (Coordination); with contributions from Ana Maranha, Ana Teresa Viegas, Daniela Costa, Inês Roxo, João Cardoso, Mafalda Costa, Mariana Silva and Susana Alarico (https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484).
Brain Voyages (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination & te. Ana Cristina Rego, Ana Luísa Carvalho, Ana Rita Álvaro, Carla Lopes, Carlos Duarte, Cláudia Cavadas, Cláudia Pereira, João Peça, Luana Naia, Luís Pereira Almeida, Nuno Empadinhas, Paula Moreira, Paulo Pinheiro, Ramiro Almeida, Ricardo Rodrigues, Sandra Morais Cardoso, Sandra Mota. (https://www.publico.pt/2017/03/24/ciencia/fotogaleria/viagens-no-cerebro-em-bd-371640).
Diabetic Journeys (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination. Alexandrina Mendes, Ana Duarte, Ana R Álvaro, Ana T Viegas, Cláudia Cavadas, Cristina Carvalho, Ermelindo Leal, Eugénia Carvalho, João Alves, John Jones, Ludgero Tavares, Mireia Alemany, Nuno Empadinhas, Paula Moreira, Paulo Oliveira, Pedro Gomes, Renata Tavares, Sandra Amaral, Sara Silva, Sónia Correia, Susana Cardoso (https://www.publico.pt/2017/11/14/ciencia/fotogaleria/viagens-na-diabetes-em).

Intellectual property

Patent

da Costa MS, Empadinhas N. 2009. "Massive production of mycobacterial glucosyl-3-phosphoglycerate synthase and the use of this enzyme as a target for antimycobacterial substances. WO2009028973.".
da Costa MS, Empadinhas N, Albuquerque L, Santos H. 2005. "Identification of a bifunctional gene for mannosylglycerate synthesis and development of a high-scale-production heterologous system based on Sacharomyces cerevisiae. EP1526180A1.".

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/03/21	Microbiologia da Doença de Parkinson e os guardiões do eixo intestino-cérebro	XVIII Congresso Científico NEF/AAC
2025/01/13	The gut microbiome in Parkinson’s Disease in a declining environment	PDBEB Advanced Course "Pathogenic Mechanisms of Neuropsychiatric and Neurodegenerative Disorders" Centro de Neurociências e Biologia Celular, Universidade de Coimbra (Coimbra, Portugal)
2024/05/22	Da biosfera ao microbioma intestinal: alimentação, imunidade e declínio da saúde global	Ciclo Sistema Imunitário e o Microbiota CECAV - AL4AnimalS - Universidade de Trás-os-Montes e Alto Douro (Portugal)
2024/03/27	A microbiologia da doença de Parkinson: os guardiões da via intestino-cérebro	Ciclo "Microbioma Humano” Academia das Ciências de Lisboa (Portugal)
2024/03/06	Aprender com as guerras entre micróbios: dos antibióticos à doença de Parkinson	Semana da Biotecnologia - Núcleo de Biotecnologia Politécnico de Leiria - Escola Superior de Turismo e Tecnologia do Mar (Portugal)
2024/02/23	Microbioma e cancro	Pós-Graduação em Bioquímica e Hematologia Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2024/01/16	Self-recycling and replication of mycobacterial methylmannose polysaccharides for cold adaptation (Ana Maranha)	7th Iberian Carbohydrate Meeting (Sitges-Barcelona, Spain)
2023/05/25	Evidence of host-microbiome interactions triggering 'Gut-first' Parkinson's Disease (Sandra Cardoso)	1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets FEBS Advanced Course (Luso, Portugal)
2023/01/17	Methylglucose vs methylmannose polysaccharides: biosynthesis, distribution and proposed roles in adaptation of mycobacteria to heat or cold	14th International Meeting of the Portuguese Carbohydrate Group (GLUPOR 14) NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal (Caparica, Portugal)
2023/01/04	What do mycobacteria and cyanobacteria have in common when it comes to public health?	DCV Talks Life Sciences Department, UC (Coimbra, Portugal)
2022/07/14	The role of the gut microbiome in neurodegenerative diseases	Portugal & Brasil Joint Meeting @CNC Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2022/06/13	Mycobacterial biogenesis of polymethylated polysaccharides	FASEB - The Microbial Glycobiology Conference FASEB Science Research Conference (SRC) (Lisboa, Portugal)
2022/05/11	Microbiome weapons and shields in metabolic, neurodegenerative and infectious diseases	Programa de Doutoramento em Ciências Farmacêuticas Faculdade de Farmácia da Universidade de Coimbra (Portugal)
2022/04/07	The gut microbiome in PD: active player or bystander?	Metabolic and Inflammatory Drivers in Age-Related Neurodegenerative Diseases PDBEB Advanced Course (Coimbra, Portugal)
2022/03/27	Microbiology of Parkinson's Disease	XIII Symposium on Bioengineering "Turning Science into Miracles" Faculdade de Engenharia da Universidade do Porto + ICBAS (Porto, Portugal)
2022/03/26	Ecologia e Epidemiologia das Micobactérias Não Tuberculosas	XXIX Congresso de Pneumologia do Norte Serviços de Pneumologia do Centro Hospitalar Universitário de São João e do Centro Hospitalar de Vila Nova de Gaia/Espinho (Centro de Congressos Sheraton Porto, Portugal)
2021/11/16	Novos caminhos de investigação em Tuberculose, na língua que nos une (Speaker: Inês Roxo)	A Bienal STEM+L 2021 - Aprendizagem da Ciência, Tecnologias, Engenharia e Matemática, na Língua que nos une OSUWELA \| UNESCO \| UPM (Maputo, Mozambique)
2021/07/14	Antimicrobial resistance in rare mycobacteria isolated from a tertiary hospital environment (Speaker: Ana Maranha)	4th International Caparica Congress In Antibiotic Resistance NOVA University of Lisbon (Caparica, Portugal)
2021/04/27	Pathogen-microbiome-host interactions in health and disease	Programa Doutoral em Ciências Farmacêuticas 2020-21 Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2021/03/16	The deadliest pathogens of all time	Doctoral Programme in Experimental Biology and Biomedicine Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2021/03/15	Microbial diversity in the 4-domain Tree of Life: an infective overview	Fighting Infection course, Doctoral Programme in Experimental Biology and Biomedicine Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2020/09/19	Mycobacteria: Complete biosynthesis of unique polysaccharides and the art of furtiveness	2nd CIBB Innovative Therapies Retreat 2020 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Universidade de Coimbra (Coimbra, Portugal)
2020/01/31	Distribution of mycobacterial polymethylated polysaccharides and their possible role in stress adaptation (Speaker: Ana Maranha)	2º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2019/12/20	Parkinsons disease: a symptom of latent infection? (Speaker: Sandra M. Cardoso)	CIBB Meeting 2019 Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/12/19	A novel mycobacterial pathway for biogenesis of rare lipid transfer polysaccharides implicated in cell envelope assembly	CIBB Meeting 2019 Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/10/01	Polysaccharide biosynthesis vs recycling and replication in mycobacteria	7th Symposium on the Alpha-Amylase Family Slovak Academy of Sciences (Smolenice, Slovakia)
2019/09/20	Unveiling mycobacterial methylmannose polysaccharide biosynthesis: a unique 1-O-methyltransferase specific for 3-O-methylated mannosides (Speaker: Jorge Ripoll-Rozada)	MycoPORTO (Speaker: Jorge Ripoll-Rozada) Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (Porto, Portugal)
2019/09/15	Cerveja: uma fonte de potenciais benefícios para a saúde do cérebro via microbioma intestinal	Brew - Mesa Redonda: Saúde e Cerveja Exploratório Ciência Viva (Coimbra, Portugal)
2019/06/07	A brave new world of gut microbiome-host interactions shaping health and disease	3as Jornadas de Cirurgia Colorectal (https://www.spcir.com/wp-content/uploads/2019/04/JORNADAS-DE-CIRURGIA-CR-ENTRE-LIS-E-TEJO-PROGRAMA-PRELIMINAR.pdf) Centro Hospitalar de Leiria (Monte Real, Portugal)
2019/06/04	O papel do eixo intestino-cérebro na Doença de Parkinson (Speaker: Sandra M. Cardoso)	IV Conference SANTA CASA Neurociências Um Olhar no Futuro" Longevidade e Doenças Neurodegenerativas Santa Casa da Misericórdia de Lisboa, Pavilhão do Conhecimento, Centro Ciência Viva (Lisboa, Portugal)
2019/05/06	Doenças causadas por micobactérias: A tuberculose e outras muito sérias	Centenário da Escola Secundária Gabriel Pereira 1919-2019 Escola Secundária Gabriel Pereira (Évora, Portugal)
2018/09/21	Molecular Mycobacteriology and the Microbiome in Communicable Diseases	9th EDCTP Forum: Clinical research and sustainable development in sub-Saharan Africa European & Developing Countries Clinical Trials Partnership (EDCTP) Coimbra Hospital and University Center (CHUC) and University of Coimbra (UC) Health Science Campus (Coimbra, Portugal)
2018/06/18	Secrets of mycobacterial biology: de novo polysaccharide synthesis vs recycling & replication	1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2018/05/17	The hidden microbiome in Parkinson's Disease (Speaker: Sandra M. Cardoso)	9th Annual World Congress NeuroTalk (Speaker: Sandra M. Cardoso) BIT Group Global (Bangkok, Thailand)
2018/04/19	Pathways to stem the tide of TB drug resistance in the midst of a TB-Diabetes storm	World Health Summit Regional Meeting 2018 University of Coimbra and Coimbra Hospital and Universitary Centre (CHUC) (Coimbra, Portugal)
2018/03/03	Viver com os micróbios: resistência a antibióticos e o microbioma humano	MeetLab - II Encontro de Laboratório Departamento Ciências da Vida, Universidade de Coimbra (Coimbra, Portugal)
2017/12/06	The gut microbiome in health and disease: key players and mechanisms	PhD Program, Molecular Mechanisms of Disease Faculdade de Medicina, Universidade de Coimbra (Coimbra, Portugal)
2017/04/07	Mycobacterial pathways from simple glycosides to fatty-acid shuttling polysaccharides	Symposium Mycobacterium: Molecular Microbiology National Center for Biotechnology, Universidad Autónoma de Madrid (Madrid, Spain)
2016/12/20	TB and not TB in the 21st century: a quest for new target-tailored precision antibiotics	1st Meeting on Biomedical Research @ UC Universidade de Coimbra (Coimbra, Portugal)
2016/10/14	Como erguer uma parede impermeável: novas pistas no genoma de Mycobacterium tuberculosis	VII Congresso Nacional da Fundação Portuguesa do Pulmão Fundação Portuguesa do Pulmão (Lisboa, Portugal)
2016/07/06	Decrypting a vital pathway of Mycobacterium tuberculosis: towards new intervention strategies	Ciência 2016 - Encontro com a Ciência e Tecnologia em Portugal Fundação para a Ciência e a Tecnologia, Centro de Congressos de Lisboa (Lisboa, Portugal)
2016/06/23	Pathway for synthesis of methylglucose lipopolysaccharide in Mycobacterium tuberculosis	The 2016 TB Summit The Royal Society of Chemistry (London, United Kingdom)
2015/06/05	Exposing cryptic mycobacterial pathways: leaving no enzyme behind	Friday Seminars at IBMC Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto (Porto, Portugal)
2015/05/07	O microbioma humano e a resistência a antibióticos num planeta de micróbios	Jornadas de Química e Bioquímica, Universidade da Beira Interior Universidade da Beira Interior (Covilhã, Portugal)
2015/04/28	O combate à tuberculose: novos intermediários metabólicos essenciais	Brokerage Event INESPO II (Speaker: Ana Maranha) Divisão de Inovação e Transferências do Saber (DITS) (Coimbra, Portugal)
2015/01/27	Mycobacterial resistance to old antibiotics and potential biosynthetic pathways for new ones	IC2AR, 1st International Caparica Conference in Antibiotic Resistance Universidade NOVA de Lisboa (Speaker: Daniela Nunes-Costa) (Caparica, Portugal)
2015/01/26	Exposing new mycobacterial drug targets from unique metabolic pathways	IC2AR, 1st International Caparica Conference in Antibiotic Resistance Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Caparica, Portugal)
2014/12/15	When microbes get on your nerves	Annual Meeting of the Center for Neuroscience and Cell Biology Universidade de Coimbra (Coimbra, Portugal)
2013/02/08	Reconstructing mycobacterial pathways from missing enzyme links: playing hide and seek	Winter CNC.IBILI Seminars Center for Neuroscience and Cell Biology (CNC) (Coimbra, Portugal)
2013/01/26	Civilização: o paraíso das micobactérias	Seminars at Instituto de Educação e Cidadania Instituto de Educação e Cidadania (Mamarrosa, Portugal)
2012/07/25	Missing links in mycobacterial MGLP biosynthesis: the early players	Seminars at the Department of Biochemistry, University of Cambridge Department of Biochemistry, Sanger Building, University of Cambridge (Cambridge, United Kingdom)
2010/09/24	O planeta das micobactérias	Palestras no Museu da Ciência Museu da Ciência da Universidade de Coimbra (Coimbra, Portugal)
2010/03/24	Biossíntese de polissacáridos raros em Mycobacterium (Dia Mundial da Tuberculose)	Feira de Ciência e Tecnologia Faculdade de Ciências e Tecnologia, Universidade de Coimbra (Coimbra, Portugal)
2008/12/16	Biosynthesis of MGLP in Mycobacterium tuberculosis. Identification of genes and characterization of enzymes	6th Annual Meeting of the Center for Neuroscience and Cell Biology (Speaker: Vitor Mendes) Fundação Bissaya-Barreto (Coimbra, Portugal)
2008/12/12	Compatible solutes in thermophiles and hyperthermophiles (Speaker: Milton Costa)	Stress Responses in the Microbial World Belgian Society for Microbiology (Brussels, Belgium)
2008/03/24	A caminho de um novo antibiótico (Dia Mundial da Tuberculose)	Semana da Tuberculose Associação Nacional de Tuberculose e Doenças Respiratórias (Lisboa, Portugal)
2007/09/03	Biosynthesis and accumulation of compatible solutes in hyper/thermophiles	Halophiles 2007 - 8th International Congress Exploring Life at High Salinity University of Essex (Colchester, United Kingdom)
2007/06/01	The accumulation and biosynthesis of compatible solutes in thermophiles and hyperthermophiles (Speaker: Milton Costa)	VII Congrés de la Société Française de Microbiologie Société Française de Microbiologie (Nantes, France)
2006/09/20	Rubrobacter xylanophilus MpgS. Evolution of MG and GG biosynthesis in prokaryotes	"Extremophiles 2006", International Conference on Extremophiles International Society for Extremophiles (Brest, France)
2006/05/22	The mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus	"HotSolutes" Final Meeting Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2004/10/15	Biosynthesis of glucosylglycerate: a "coldsolute" from prokaryotes	3rd "HotSolutes" Meeting Universita Degli Studi di Ferrara (Ferrara, Italy)
2004/09/25	Nature's shields to environmental stress: biosynthesis of compatible solutes in extremophiles	2nd Annual Meeting of the Center for Neuroscience and Cell Biology Center for Neuroscience and Cell Biology (Luso, Portugal)
2004/02/27	Optimizing mannosylglycerate production by Saccharomyces cerevisiae	1st "HotSolutes" Meeting Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2003/11/21	Production of mannosylglycerate by Saccharomyces cerevisiae	6th "Hypersolutes" Meeting Technische Universtität Hamburg (Hamburgo, Germany)
2003/03/08	Production of mannosylglycerate in mesophilic organisms	5th "Hypersolutes" Meeting Instituto de Tecnologia Química e Biológica (Alcochete, Portugal)
2002/03/01	Synthesis of mannosylglycerate at room temperature: properties of a mesophilic mannosylglycerate synthase	3rd "Hypersolutes" Meeting Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2001/10/23	Genes for the synthesis of mannosylglycerate at high and room temperature: characterization of key-enzymes	2nd "Hypersolues" Meeting Universitaet Konstanz (Konstanz, Germany)
2001/07/02	Biosynthesis of mannosylglycerate in the hyperthermophile Pyrococcus horikoshii: characterization of key-enzymes	27th FEBS Meeting Federation of European Biochemical Societies (Lisboa, Portugal)
2001/02/10	Mannosylglycerate biosynthesis in Pyrococcus horikoshii: characterization of key-enzymes	1st "Hypersolutes" Meeting Instituto de Tecnologia Química e Biológica (ITQB) (Oeiras, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	Microbial synthesis of neuroactive metabolites and bacteriotherapeutic strategies in PD Supervisor of Sara Miguel Gonçalves	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024 - Current	Deciphering the interplay between bacterial extracellular vesicles and intestinal immune regulation in autism spectrum disorder Co-supervisor of Inês Melo Marques	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023 - Current	Novos diterpenóides semi-sintéticos para o tratamento de infeções resistentes Co-supervisor of Olha Antoniuk	Ciências Farmacêuticas (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - Current	Impact of the gut microbiome in the immune modulation of TB infection Supervisor of Inês Cravo Roxo	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra, Portugal
2021 - 2025	Deciphering the Impact of Microbiome-Immune Interplay in Schizophrenia Co-supervisor of Ana Raquel Santos	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra, Portugal
2023 - 2024	Activation of innate immunity in macrophages by nontuberculous mycobacteria Co-supervisor of Sara Tatiana Freitas	Bioquímica (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019 - 2024	The impact of bacterial infection in gut first Parkinson’s Disease: the influence of innate immunity activation in alpha-synuclein expression and mitochondrial dysfunction Co-supervisor of João Duarte Magalhães	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2023	Conflicting interactions between methylobacteria and mycobacteria from drinking water Co-supervisor of Ana Afonso Dias	Microbiologia (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022 - 2023	Profiling mycobacteria isolated from the houses of patients with NTM disease Co-supervisor of Maria Carolina Fernandes	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2022	Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology Supervisor of Daniela Cristina Nunes Costa	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra, Portugal
2020 - 2021	Biosynthesis of serotonin in bacteria: an exploratory study Supervisor of Sara Miguel Gonçalves	Biotecnologia Farmacêutica (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2021	Identification of NTM proteins involved in cell aggregation and biofilm formation Co-supervisor of Ana Rita Fonseca	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019	Esterilização supercrítica de aerogéis compostos por polímeros naturais para aplicações biomédicas Co-supervisor of Cristiana Amaral Bento	Engenharia Química (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2019	Mycobacterial methylmannose polysaccharides’ biosynthesis Supervisor of Maria Mafalda Santos Costa	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 - 2018	Antimicrobial susceptibility and competition of diabetic skin microbiota Co-supervisor of Antonella DiCaro	Erasmus+ Programme (Specialization course) Università degli Studi del Sannio, Italy
2016 - 2018	Deciphering microbiome signatures in chronic diseases Supervisor of Ana Branco Maranha Tiago	Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2018	Functional and structural studies of potential targets of mycobacterial pathways Co-supervisor of Jorge Ripoll Rozada	Pós-Doutoramento Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015 - 2018	Defining the missing links in mycobacterial methylglucose lipopolysaccharide biosynthesis Supervisor of Susana Isabel Elias Alarico	Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2018	Biochemical and structural characterization of mycobacterial drug targets Co-supervisor of Tatiana Barros Reis Cereija	Biologia Molecular e Celular (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017	Isolation of ESKAPE pathogens from diabetic wounds Co-supervisor of Pau Porras Socias	Biotechnology (Erasmus+ Programme) (Master) Universitat de Barcelona Facultat de Biologia, Spain
2015 - 2016	Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stress Supervisor of Cristina Isabel da Silva Martins	Biotecnologia Farmacêutica (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2016	Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratório Supervisor of Ana Catarina Silva Monteiro	Biotecnologia Farmacêutica (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2016	Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis Supervisor of Ana Branco Maranha Tiago	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015	Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria Supervisor of Daniela Cristina Nunes Costa	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2015	Molecular and physiological characterization of two crucial enzymes from M. tuberculosis Supervisor of Vitor Gonçalo Costa Mendes	Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2015	The early steps in methylglucose lipopolysaccharide biosynthesis in mycobacteria Supervisor of Susana Isabel Elias Alarico	Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014	Perfis de resistência a antimicrobianos de estirpes de Mycobacterium isoladas de ambiente hospitalar Supervisor of Diogo José Pereira Reis	Biotecnologia dos Recursos Marinhos (Master) Instituto Politécnico de Leiria, Portugal
2012 - 2013	Biosynthesis of rare methylglucose lipopolysaccharides in rapidly-growing mycobacteria : characterization of a key hydrolase Supervisor of Maria Mafalda Santos Costa	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012	Análise funcional de maltocinases e trealose sintases/maltocinases bifuncionais Supervisor of Andreia Filipa Nisa Mendes Lamaroso	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2012	Deciphering the regulatory mechanisms controlling compatible solutes biosynthesis in Thermus thermophilus osmo- and thermoadaptation Supervisor of Susana Isabel Elias Alarico	Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2011	New insights into the biosynthesis of the mycobacterial methylglucose lipopolysaccharide Supervisor of Vitor Gonçalo Silva e Costa Mendes	Bioquímica / Especialidade Microbiologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2010	A multifactorial approach to the biological role of the mycobacterial maltokinase Supervisor of Ana Branco Maranha Tiago	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2009	Relevance of MG and trehalose in the osmoadaptation of Thermus thermophilus Co-supervisor of Susana Isabel Elias Alarico	Biologia / Especialidade Microbiologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2009	Osmotic and thermal adaptation in ancient thermophilic bacteria : biosynthesis of glucosyglycerate and mannosylglucosylglycerate Co-supervisor of Chantal Ana Vicência Fernandes	Bioquímica / Especialidade Microbiologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2025/09/15 - 2025/09/17	International Joint Meeting GLUPOR 15 & GLYCOTwinning 2025 (https://glupor15.events.chemistry.pt/) (2025/09/15 - 2025/09/17) Meeting (President of the Organising Committee)	Sociedade Portuguesa de Química, Portugal
2025/06/22 - 2025/06/25	The 45th Annual Congress of the European Society of Mycobacteriology (https://www.esmycobacteriology.eu/event-home) (2025/06/22 - 2025/06/25) Congress (Member of the Organising Committee)
2024/05/15 - 2024/05/16	BEB Day 2024 - (Not) Knowing What Comes Next. Coordinators: Nuno Empadinhas & John Jones; Organizing Committee: Alejandra Nunez, Carolina Mendes, Luísa Matos, Sofia Figueira, Beatriz Ribeiro, Emanuel Tahiri, Inês Moniz, João Gabriel Silva, Laura Carvalho, Mariana Diniz, Sara Martins, Simão Santos, Solange Martins. https://cnc.uc.pt/en/dia-do-beb-2024 (2024/05/15 - 2024/05/16) Symposium	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/01/15 - 2024/01/17	7th Iberian Carbohydrate Meeting (https://www.iberiancarbohydrate2024.com/index.php/organizers) (2024/01/15 - 2024/01/17) Conference (Member of the Organising Committee)	Carbohydrate Group of the Real Sociedad Española de Química (RSEQ), Spain Grupo dos Glúcidos da Sociedade Portuguesa de Química, Portugal
2023/02/07 - 2023/02/08	BEB Day 2023 - Science Challenges. Coordinator: Nuno Empadinhas; Organizing Committee: Ana Vasconcelos, Débora Mena, Frederico Pena, João Novo, Maria Inês Cristo, Rafaela Ferrão. https://www.uc.pt/iii/agenda-ensino-iiiuc/beb-day-2023/ (2023/02/07 - 2023/02/08) Symposium (Member of the Organising Committee)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2022/01/18 - 2022/01/19	BEB Day 2022 - The Overview Effect. Coordinator: Nuno Empadinhas. Organizing Committee: Carlos Barreto, Inês Caramelo, Inês Roxo, Luís Grilo, Maria Alfaiate, Mariana Magalhães, Raquel Santos, Rita Santos. https://www.uc.pt/en/iii/bebday/bebday2022/ (2022/01/18 - 2022/01/19) Symposium (Member of the Scientific Committee)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2021/09/17 - 2021/09/17	3rd CIBB Innovative Therapies Retreat 2021. Organizing Committee: Nuno Empadinhas, Irina Moreira, Hugo Fernandes. (2021/09/17 - 2021/09/17) Meeting (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/05 - 2019/04/05	Mycobacterial Glycoimmunology Joint Meeting 2019. Organizers/Participants: Nuno Empadinhas, Margarida Correia Neves, Gunilla Kallenius, Chritopher Sundling, Susana Alarico, Ana Maranha, Mafalda Costa, Daniela Costa. (2019/04/05 - 2019/04/05) Meeting (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/12/07 - 2018/12/07	1st Microbiome-Gut-Brain Axis Joint Meeting. Organizers: Nuno Empadinhas & Sandra M. Cardoso. (2018 - 2018) Meeting (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/06/18 - 2018/06/18	1º Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal. Chair: Nuno Empadinhas. Scientific Committee: Raquel Duarte, Margarida Correia-Neves, Miguel Viveiros. Organizing Committee: Mafalda Costa, Ana Maranha, Susana Alarico, Daniela Costa, John D. Marugg, Olena Radomska. (2018/06/18 - 2018/06/18) Symposium (President of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Minho Escola de Medicina, Portugal Universidade do Porto Instituto de Saúde Pública, Portugal Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2025/07/16	Development of a colorimetric bacterial detection device for urinary catheters (Thesis) Arguer	Marta Patrícia Carvalho dos Santos (PhD) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2024/12/18	Salmonella-host cell interactions: Unraveling key host determinants of infection of epithelial cells (Thesis) Arguer	Jane Santos Dias (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/03/25	Impact of Nutrition on Gut Microbiota: Implications to Parkinson's Disease (Thesis) Main arguer	Joana Rocha Sobral (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2024/03/18	Deciphering unexploited features of drug-repurposing beta-lactams against tuberculosis: from genomic patterns of Mycobacterium tuberculosis susceptibility to synergistic combinations (Thesis) Main arguer	Francisco Olivença Miguel (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/01/30	Staphylococcus aureus intracellular lifestyle: phenotypic profiles and underlying molecular determinants (Thesis) Arguer	Inês Rodrigues Lopes (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/27	The role of micronutrients in unconventional T cells: How RA-signalling controls iNKT cells development (Thesis) Main arguer	Diogo Vieira da Silva (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/03/21	Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology Supervisor	Daniela Cristina Nunes Costa (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/16	Enterobacteriaceae as mediators for carbapenems resistance transfer between environmental and human settings (Thesis) Arguer	Pedro Filipe de Sá Teixeira (PhD) Universidade de Aveiro, Portugal
2021/11/30	Risk factors associated with multidrug-resistant tuberculosis transmission in Portugal (Thesis) Main arguer	Olena Radomska (PhD) Universidade do Minho Escola de Medicina, Portugal
2020/12/16	Changes in the gut-brain axis during aging (Thesis) Main arguer	João Tomás Barros (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/07	Towards a better understanding of host cell requirements for Salmonella cytosolic replication (Thesis) Main arguer	Susana Santos Costa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/07/22	Mycobacterial methylmannose polysaccharides’ biosynthesis Supervisor	Maria Mafalda Santos Costa (PhD) Universidade de Coimbra, Portugal
2018/09/28	Novos materiais para a oxigenação melhorada de culturas de células e de scaffolds para engenharia de tecidos (Thesis) Main arguer	Mariana Hugo Silva (Master) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2017/06/16	O papel do mitoribossoma na função mitocondrial: Implicações para a Doença de Parkinson (Thesis) Main arguer	Ana Mafalda Gonçalves (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06/09	Unraveling the protection mechanisms in the radiation resistant bacterium Deinococcus radiodurans (Thesis) Main arguer	Sandra Isabel Santos (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09/24	Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em Streptacidiplilus jiangxiensis sob diferentes condições de stress Supervisor	Cristina Martins (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/23	Colesterol Oxidase, Hormonas Sexuais e Suscetibilidade à Tuberculose Supervisor	Ana Monteiro (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/07/25	A genomic exploration of transmissibility in Mycobacterium tuberculosis (Thesis) Main arguer	Hanna Nebenzahl Guimarães (PhD) Universidade do Minho Escola de Medicina, Portugal
2016/01/13	Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis Supervisor	Ana Branco Maranha Tiago (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/07/17	Molecular characterization of Klebsiella pneumoniae beta-lactamases from patients with renal transplants admitted to the Coimbra University Hospital (Thesis) Arguer	Delfino Vubil (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/17	Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria Supervisor	Daniela Cristina Nunes Costa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/13	Characterizing Iron Transporters in Plasmodium species (Thesis) Main arguer	Aparajita Lahree (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/11/26	New Retroviral-Like Membrane-Associated Aspartic Proteases from Rickettsiae: Biochemical Characterization and Specificity Profiling (Thesis) Arguer	Rui Gonçalo Cruz (PhD) Universidade de Coimbra, Portugal
2014/11/07	Fe/S Cluster Biogenesis Regulation by the Janus-faced Regulator, IscR: An Unforeseen Mechanism of DNA Recognition and Discrimination (Thesis) Arguer	Joana Abreu Santos (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/10/29	Perfis de resistência a agentes antimicrobianos de 5 estirpes do género Mycobacterium isoladas de ambiente hospitalar Supervisor	Diogo Reis (Master) Instituto Politécnico de Leiria, Portugal
2013/10/31	Diversity of arsenite transporter genes in microbial populations of the abandoned uranium mine in Urgeiriça (Thesis) Main arguer	Rui Marques Costa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09/20	Screening of Saccharomyces cerevisiae strains for recombinant protein expression (Thesis) Main arguer	Paulo Espírito Santo (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07/12	Biosynthesis of methylglucose lipopolysaccharides in rapidly growing mycobacteria: characterization of a key hydrolase Supervisor	Mafalda Santos Costa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/07	Analysis of the antimicrobial content of amphibian skin secretions and structural and functional characterization of a novel member of the temporin family (temporin-SHe) (Thesis) Main arguer	Sónia Costa André (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/06	Análise functional de maltocinases e trealose sintases/maltocinases bifuncionais Supervisor	Andreia Mendes Lamaroso (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/06/04	The Adaptive Response of Mycobacterium avium to Anoxia and Nitric Oxide (Thesis) Main arguer	John Edward Pearl (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/05/11	Structure-function Relationships in a Glycosyltransferase, a Phosphatase and an Oxidoreductase (Thesis) Arguer	Susana Pires Gonçalves (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/12/09	New Insights into the Biosynthesis of the Mycobacterial Methylglucose Lipopolysaccharide Supervisor	Vitor Gonçalo Silva Costa Mendes (PhD) Universidade de Coimbra, Portugal
2011/09/19	Estratificação vertical das comunidades microbianas da zona mesopelágica, no Atlântico Norte, determinada por pirosequenciação do 16S DNAr (Thesis) Main arguer	Luísa Silva Lopes (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07/19	Characterization of bacterial strains resistant to uranium for use in bioremediation (Thesis) Main arguer	Tânia Miranda Sousa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/04/01	Formation and analysis of metal-induced phosphate rich extracellular nano-particulate in the Cr(VI) resistant strain Ochrobactrum tritici 5bv11 (Thesis) Main arguer	Pedro Miguel Abreu (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/10	Evolução molecular dos genes pilD e lspE de Legionella pneumophila (Thesis) Main arguer	Ana Filipa d’Avó (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/09	A multifactorial approach to the biological role of the mycobacterial maltokinase Supervisor	Ana Branco Maranha Tiago (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009/07/24	Osmotic and Thermal adaptation in ancient thermophilic bacteria. Glucosylglycerate and mannosylglucosylglycerate Supervisor	Chantal Vicência Fernandes (PhD) Universidade de Coimbra, Portugal
2009/03/30	Relevance of Mannosylglycerate and Trehalose Accumulation in the Osmoadaptation of Thermus thermophilus Supervisor	Susana Isabel Elias Alarico (PhD) Universidade de Coimbra, Portugal
2008/09/30	Role of Hsp60 and its peptide aa437-460 in experimental Sjogren’s syndrome (Thesis) Arguer	Ana Carina Madureira (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2024 - Current	ACS Infectious Diseases (2373-8227)	ACS Publications
2024 - Current	Gut Microbes (1949-0984)	Taylor & Francis
2024 - Current	Ecotoxicology and Environmental Safety (0147-6513)	Elsevier
2021 - Current	Neurotoxicity Research (1029-8428)	Springer
2021 - Current	Pulmunology (2531-0437)	Elsevier
2020 - Current	European Journal of Clinical Investigation (1365-2362)	Wiley (Blackwell Publishing)
2020 - Current	Microorganisms (2076-2607)	MDPI AG
2020 - Current	Neuropsychiatric Disease and Treatment (1176-6328)	Dove Medical Press
2017 - Current	Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine (1179-5484)	"Libertas Academica, Ltd."
2016 - Current	Archaea (1472-3654)	Hindawi Limited
2015 - Current	PLoS ONE (1932-6203)	Public Library of Science
2015 - Current	Scientific Reports (2045-2322)	Nature
2014 - Current	Biochimica et Biophysica Acta - General Subjects (0304-4165)	Elsevier
2014 - Current	Frontiers in Molecular Biosciences (2296-889X)	Frontiers Media SA
2014 - Current	Microbial Drug Resistance (1931-8448)	Mary Ann Liebert
2014 - Current	World Journal of Microbiology and Biotechnology (1573-0972)	Springer-Verlag
2013 - Current	Tuberculosis (1472-9792)	Elsevier
2012 - Current	Folia Microbiologica (1874-9356)	Springer-Verlag
2011 - Current	Applied Microbiology and Biotechnology (1432-0614)	Springer-Verlag
2010 - Current	BMC Genomics (1471-2164)	Springer (Biomed Central Ltd.)
2010 - Current	Enzyme and Microbial Technology (0141-0229)	Elsevier
2010 - Current	Marine Drugs (1660-3397)	MDPI AG
2010 - Current	Research in Microbiology (0923-2508)	Elsevier
2008 - Current	Extremophiles (1433-4909)	Springer-Verlag
2008 - Current	Journal of Bacteriology (1098-5530)	American Society for Microbiology

Association member

	Society Organization name	Role
2023 - Current	SPQ - Sociedade Portuguesa de Química
2018 - Current	ASM – American Society for Microbiology
2014 - Current	NTM-NET
2014 - Current	TBnet
2013 - Current	ESM - European Society of Mycobacteriology
2006 - 2016	SPM - Sociedade Portuguesa de Microbiologia

Committee member

	Activity description Role	Institution / Organization
2025 - Current	Local Advisory Board of CoARA-funded UC TREASURE project Advisor / Consultant	Universidade de Coimbra, Portugal
2021 - Current	Associate Editor "Biologia" (Cellular and Molecular Biology) (1336-9563) Member	Springer Nature Switzerland AG, Switzerland
2021 - Current	Advanced Studies Office Member	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - Current	Associate Editor of "BMC Microbiology" (Microbial Biochemistry, Physiology and Metabolism) Member	BioMed Central Ltd, United Kingdom
2020 - Current	Editorial Board of "Antibiotics" (Antibiotic Biosynthesis' Section) (2079-6382) Member	Multidisciplinary Digital Publishing Institute AG, Switzerland
2019 - 2020	Guest Associate Editor of "Frontiers in Immunology" (Nutritional Immunology) (1664-3224) Member	Frontiers Media SA, Switzerland
2016 - 2019	Coordinator CNC.IBILI Seminars Program - Center for Neuroscience and Cell Biology Coordinator	CNC.IBILI, Portugal
2015 - 2018	Editorial Board of "Scientific Reports" (2045-2322) Member	Springer Nature Limited, United Kingdom

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020 - 2024	Invited lecturer, "Micobactérias Não Tuberculosas" course (Coordinator: Raquel Duarte)	(Especialização pós-licenciatura)	Universidade do Porto Instituto de Saúde Pública, Portugal
2015 - 2024	Invited lecturer, "Biology of Ageing" course, Masters in Biomedical Engineering (Coordinator: Sandra M. Cardoso)	Biologia do Envelhecimento (Mestrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2024	Invited lecturer, "Aging" course, Masters in Cell and Molecular Biology (Coordinator: Emília Duarte)	Biologia Celular e Molecular (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/02/17 - 2023/03/10	Invited lecturer, "Bacteriologia Clínica" course (Coordinator: Nádia Osório)	Bacteriologia Clínica (Pós-Graduação)	Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2021 - 2023	Invited lecturer, "Tuberculose" course (Coordinator: Raquel Duarte)	(Especialização pós-licenciatura)	Universidade do Porto Instituto de Saúde Pública, Portugal
2021 - 2022	Invited lecturer, "Doutoramento em Ciências Farmacêuticas" (Coordinators: João Laranjinha)	Ciências Farmacêuticas (Doutoramento)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2021	Course "Fighting Infection" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Nuno Empadinhas, Susana Alarico, Isaura Simões)	PhD Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019	Invited lecturer, "Química Farmacêutica II" (Coordinator: Maria Manuel Silva)	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019	Invited lecturer, "Tecnologia de Produção de Vacinas" (Coordinator: Olga Borges)	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019	Invited lecturer, "Biologia Translacional e Biomedicina" (Coordinator: João Ramalho Santos)	Biologia (Licenciatura)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013 - 2015	Course "Microbiologia e o Microbioma Humano", Instituto de Educação e Cidadania (IEC) (Coordinators: Nuno Empadinhas & Susana Alarico)	(Ensino secundário)	Instituto de Educação e Cidadania (IEC), Portugal
2012 - 2012	Course "Medical Microbiology" of the PhD Programme in Experimental Biology and Biomedicine (Coordination: Medical Microbiology Group)	(Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2012	Invited lecturer, "Microbiologia e Parasitologia", Masters in Public Health (Coordinator: Teresa Gonçalves)	Saúde Pública (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2008 - 2011	Molecular Microbiology (Masters in Biochemistry)	Masters in Biochemistry (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2011	Microbiology (Degree in Biochemistry)	Bioquímica (Licenciatura)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2006 - 2011	Course "Microbiology" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Nuno Empadinhas & Milton da Costa)	PhD Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002 - 2007	Invited lecturer, "Microbiologia" (Coordinator: Milton da Costa)	Bioquímica (Licenciatura)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2005 - 2005	Course "Microbiology of Extreme Environments" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Milton da Costa & Nuno Empadinhas)	PhD Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002 - 2003	Invited lecturer, "Evolução e Biodiversidade" (Coordinator: Milton da Costa)	Biologia (Licenciatura)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023 - Current	ANR Grants, Cellular Biology, Developmental Biology and Evolution Evaluator	Agence nationale de la recherche, France	Agence nationale de la recherche
2024 - 2024	ERA-NET NEURON , ”Transnational Research Projects on Bidirectional Brain-Body Interactions” Evaluator	Fundación Española para la Ciencia y la Tecnología, Spain	ERA-Net Cofund scheme
2019 - 2023	FCT Final Grant Reports, Panel Experimental Biology and Biochemistry Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2021 - 2021	Innovate Competition, iMed Conference® 13.0 - Lisbon 2021, Jury A Evaluator	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	AstraZeneca Foundation
2019 - 2020	REWIRE - Reinforcing Women in Research (https://rewire.univie.ac.at/) Evaluator	University of Vienna, Austria, Austria	COFUND Programme, Marie Sklodowska Curie Actions COFUND Project, European Commission
2015 - 2015	ANR Grants, Panel Immunology and Infection Evaluator	Agence nationale de la recherche, France	Agence nationale de la recherche
2014 - 2014	Health and Medical Research Fund, Final Grant Reports Evaluator	Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region, Hong Kong SAR China	Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2024/03/27	Ciclo de conferências "Microbioma Humano", Academia das Ciências de Lisboa https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/	Diário de Notícias
2020/06/01	Editor's Choice May 2020: Understanding a Mycobacterial Thermophile https://microbiologysociety.org/blog/microbiology-editor-s-choice-understanding-a-mycobacterial-thermophile.html	Microbiology Society UK
2019/03/24	Viagens na Tuberculose - Banda desenhada comemorativa do Dia Mundial da Luta Contra a Tuberculose https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484	Público

Interview (tv / radio show)

	Program	Topic
2022/03/18 - 2022/03/18	Rádio TSF Noticiário	Thiomargarita magnífica: descoberta uma bactéria colossal
2021/10/13 - 2021/10/13	A Saúde no Saber	Microbiologia e Doenças Infeciosas
2019/03/03 - 2019/03/03	Ciência aos Domingos	Doenças causadas por micobactérias, da Tuberculose às infecções pulmonares atípicas
2016/12/02 - 2016/12/02	SIC - Jornal da Noite	Prémio Santa Casa Neurociências Mantero Belard
2015/12/10 - 2015/12/10	RTP 1 - Jornal da Tarde	Descoberta de enzima essencial de Mycobacterium tuberculosis
2015/10/21 - 2015/10/21	Bolsas de Ignição	Produção de compostos essenciais para investigação em doenças causadas por micobactérias
2009/10/02 - 2009/10/02	TVI - Jornal da Uma	Micróbio resistente a radiações

Other jury / evaluation

	Activity description	Institution / Organization
2021/07/20 - Current	Ana Isabel Gonçalves Roque, "Blood microbiome: insights into gut barrier function and autoimmunity development in Celiac Disease" - Projecto de Tese e Comissão de Acompanhamento de Tese (CAT), Programa Doutoral em Biologia, Universidade Nova de Lisboa	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11/25 - 2022/11/25	Teresa Paula Marques "Impacto da Microbiota Oral e Intestinal na Infeção Covid-19" Relatório de Ano Probatório do Doutoramento em Ciências Biomédicas do Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto.	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/11/10 - 2015/11/10	André Lázaro Correia "Bariatric surgery and gut microbiome shifts: is there a difference between gastric sleeve and gastric bypass?", Projecto de Tese, Programa de Doutoramento em Ciências da Saúde, Faculdade de Medicina, Universidade de Coimbra	Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07/16 - 2015/07/16	Pedro Curto "The retropepsin-like enzyme RC1339/APRc from Rickettsiae as a potential therapeutic target for rickettsial diseases", Thesis Project, PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra.	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Scientific expedition

	Activity description	Institution / Organization
2018/06 - 2018/10	Expedition "Domestic NTM - There must be something in the water". Organization and sampling: Nuno Empadinhas, Susana Alarico, Daniela Machado. Coimbra/Aveiro/Braga/Porto Districts.	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Instituto de Saúde Pública, Portugal
2008/10/23 - 2008/10/25	Expedition "Furnas - Novel thermophiles". Organization: Nuno Empadinhas & Milton S. da Costa. Sampling: Nuno Empadinhas & Sandra M. Cardoso. Furnas, São Miguel Island, Azores	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/09/04 - 2004/09/09	Expedition "Hotspots - Isolation of thermophiles from Azorean Hotsprings for biotechnological applications". Organization: Milton S. da Costa, Nuno Empadinhas, Garabed Antranikian. Sampling: Nuno Empadinhas, Ana Nobre, Rami Al-Khudary, Ksenia Egorova, Moritz Katzer, with technical support by the University of the Azores, Ponta Delgada	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Technische Universität Hamburg Studiendekanat Gewerblich-Technische Wissenschaften, Germany
1998/07/29 - 1998/08/03	Expedition "Keratin - New keratin-degrading thermophiles from hotsprings in São Miguel Island". Organization and sampling: Milton S. da Costa & Nuno Empadinhas, with technical support from the University of the Azores, Ponta Delgada, Azores	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade dos Açores, Portugal

Distinctions

Award

2023	Pfizer Award in Basic Research Sociedade de Ciências Médicas de Lisboa & Pfizer, Portugal
2020	Prémio Projetos Semente de I&D "Era pós-COVID 19" Universidade de Coimbra/Santander, Portugal
2017	Thomé Villar Award, Sociedade Portuguesa de Pneumologia & Boehringer Ingelheim Sociedade Portuguesa de Pneumologia, Portugal
2016	Santa Casa Neurociências Mantero Belard Award Santa Casa da Misericórdia de Lisboa, Portugal
2012	Mizutani Foundation for Glycoscience - Exploratory Glycoscience Grant Mizutani Foundation for Glycoscience, Japan, Japan

Other distinction

2024	Article featuring the cover of "Natural Product Reports" (Volume 41, December) Royal Society of Chemistry, United Kingdom
2021	Article featuring the cover of "Antioxidants & Redox Signaling" (Volume 34, Issue 8, March) Mary Ann Liebert, Inc., publishers, United States
2020	Editor's Choice Article selected for the May Issue of "Microbiology" (Volume 166, Issue 5) Microbiology Society, United Kingdom
2011	Article featuring the cover of "Molecular Microbiology" (Volume 79, Issue 1, January) Molecular Microbiology Editorial Board (Wiley Blackwell Publishing), United States