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Principal Investigator and Group Leader at the CNC-Center for Neuroscience and Cell Biology, and CiBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra (UC), Portugal. Coordinator of the PhD Programme in Experimental Biology and Biomedicine (PDBEB) and of the Advanced Studies and Career Development Office at CNC/CiBB since 2024. President of the Carbohydrate Group of the Portuguese Chemical Society (SPQ) since 2025. Biologist with a PhD in Biochemistry/Microbiology from the UC (advisors: Milton S. da Costa (UC), Helena Santos (ITQB-NOVA), John D. Marugg (Nestlé Research Center, CH). Current research interests are focused on nontuberculous mycobacteria (NTM) from drinking water systems, on discovery of novel natural and synthetic antimicrobials, and microbial biosynthesis of neuroactive metabolites by gut microbiota. His work in Parkinson’s disease models uncovered a toxic pathway linking chronic ingestion of the microbial toxin BMAA through aquatic foods to unmonitored health risks in human populations. As a molecular microbiologist, he has elucidated mechanisms of microbial adaptation to diverse extreme environments, including hot springs, salterns, hydrothermal environments, deserts, through discovery and characterization of biosynthetic pathways for glycosidic compatible solutes in extremophiles, and has clarified key steps in the biosynthesis of polysaccharides in Mycobacterium tuberculosis and NTM. In this capacity, he has identified genes and enzymes that were founders of 17 new families in the IUBMB enzyme nomenclature (https://www.enzyme-database.org/query.php?name=Empadinhas). Has co-authored over 90 peer-reviewed publications, including 7 book chapters and 2 international patents, accumulating over 3,400 citations and an h-index of 36 (Google Scholar). His transdisciplinary research has attracted over €2 million in competitive funding (FCT-Fundação para a Ciência e a Tecnologia, Mizutani Foundation for Glycoscience, Santa Casa da Misericórdia de Lisboa, Infarmed, SPP/Boehringer Ingelheim, SCML/Pfizer). Supervised 10 PhD theses and 15 MSc theses, delivered >50 invited lectures, served on multiple grant evaluation panels, (e.g. Agence Nationale de la Recherche, MSCA-REWIRE, ERA-NET, Hong Kong Health and Medical Research Fund, FCT). Acted as peer reviewer for >25 scientific journals. His work has been recognized with several distinctions, including the Mizutani Grant (2012), the first Portuguese scientist to receive this distinction since its inception in 1993, the Mantero Belard Award (2016), the Thomé Villar Award (2017), the UC Seed Project Award (2020), and the Pfizer Award in Basic Research (2023).
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Identification

Personal identification

Full name
NUNO MIGUEL DA SILVA EMPADINHAS

Citation names

  • Empadinhas, Nuno

Author identifiers

Ciência ID
C511-C024-BE7A
ORCID iD
0000-0001-8938-7560
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=-jHQdEgAAAAJ&view_op=list_works
Researcher Id
AAC-6157-2019
Scopus Author Id
6602504934

Email addresses

  • nuno.empadinhas@uc.pt (Professional)
  • numenius@cnc.uc.pt (Professional)
  • nempadinhas@gmail.com (Personal)

Telephones

Telephone
  • (+351) 304502931 (Professional)
  • (+351) 239820190 Ext.: 140 (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular (CNC), Rua Larga, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
Education
Degree Classification
2000 - 2004
Concluded
 Bioquímica (Doctorate)
Major in Specialty in Microbiology
Universidade de Coimbra, Portugal
"Pathways for the synthesis of mannosylglycerate in prokaryotes. Genes, enzymes and evolutionary implications" (THESIS/DISSERTATION)
 Distinction and Honours
1997 - 1999
Concluded
 Biologia Celular (Master's Degree (completion of specialization degree))
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 Very Good
1990 - 1996
Concluded
 Biologia (Licenciate Degree)
Major in Microbiologia
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR" (THESIS/DISSERTATION)
 Good
1986 - 1989
Concluded
 Quimicotecnia (High School)
Escola Secundária André de Gouveia, Portugal
Affiliation

Science

Category
Host institution		 Employer
2024 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019 - 2023 Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2018 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2007 Postdoc (Research) European Commission Sixth Framework Programme, Belgium
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2000 - 2004 Visiting Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
1997 - 1999 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Teaching in Higher Education

Category
Host institution		 Employer
2008 - 2011 Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

Category
Host institution		 Employer
2025/09 - Current President - Carbohydrate Group, Portuguese Chemical Society (SPQ) Sociedade Portuguesa de Química, Portugal
Sociedade Portuguesa de Química, Portugal
2024/06 - Current Coordinator - PhD Programme in Experimental Biology and Biomedicine (PDBEB) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/06 - Current Coordinator - Advanced Studies and Career Development Office Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
(...)
2022 - Current Member of Scientific Council - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2018 - Current Group Leader - Molecular Microbiology and Microbiome Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
(...)
2016 - 2018 Coordinator - Annual Seminar Series at CNC Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2018 Group Leader - Molecular Mycobacteriology and Microbiome Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2000 - 2012 Researcher - Microbiology of Extreme Environments Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Contract

Designation Funders
2025 - 2029 WATERGATE: Drinking water microbiota with implications for chronic diseases
COMPETE2030-FEDER-00676000
Principal investigator
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
2025 - 2028 GAinPD - Arrest PD with new bacterial-derived anti-inflammatory mediators
COMPETE2030-FEDER-00675300
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2026 Validation of bacterial-derived anti-inflammatory mediators in gut-first PD
CP code: SC01
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Cure Parkinson's UK
Ongoing
2023 - 2025 AMRFIGHT - Exploring bacterial interactions to find novel molecules to combat the antimicrobial resistance catastrophe
2022.06809.PTDC
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025 NTMENACE - Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic
PTDC/BIA-MIC/0122/2021
Principal investigator
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023 mi-PD-RNAs - Microbiome-miRNAs axis in Parkinsons disease: involvement of mitochondrial mediated inflammatory response
EXPL/MED-NEU/1515/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2021 - 2023 The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 STERILAEROGEL - Green method to prepare sterilized biopolymers based aerogel
PTDC/EQU-EPQ/32625/2017
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020 - 2021 Sustainable and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system
Prémio Projetos Semente de I&D "Era pós-COVID 19: uma sociedade mais sustentável, resiliente e justa
Researcher
Universidade de Coimbra, Portugal
 Universidade de Coimbra/Santander
Concluded
2018 - 2021 POLYREP - An intriguing mycobacterial polysaccharide: recycling, replication and beyond
PTDC/BTM-TEC/29221/2017
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2021 HealthyAging2020 (WP9 - Deciphering microbiome signatures in chronic diseases for early diagnosis and modulation therapies) (Institutional-HR)
CENTRO-01-0145-FEDER-000012-N2323
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
 European Regional Development Fund

Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2017 - 2020 The toxinogenic gut microbiome in sporadic Parkinson's Disease: a quest for "antiPDbiotics"
Mantero Belard Prize 2016 - MB-40-2016
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Santa Casa da Misericórdia de Lisboa
Concluded
2018 - 2018 Prevalência de micobactérias não tuberculosas em ambiente doméstico
Prémio Thomé Villar/Boehringer Ingelheim 2017
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Sociedade Portuguesa de Pneumologia

Boehringer Ingelheim Portugal
Concluded
2016 - 2018 MICROCARE - Microbiome of diabetic ulcers: early diagnosis, prognosis and therapy
FIS-2015-01_DIA_20150630-144
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
 Infarmed - Fundo para a Investigação em Saúde
Concluded
2016 - 2016 The impairment of neuronal metabolism by gut microbiome effectors
FMUC-BST-2016-221
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Faculdade de Medicina, Universidade de Coimbra & Banco Santander
Concluded
2014 - 2015 Produção e comercialização global de compostos microbianos para investigação
InovC 2014
Principal investigator
Universidade de Coimbra, Portugal
 European Regional Development Fund
Concluded
2013 - 2015 Biosynthesis of rare methylmannose polysaccharides in nontuberculous mycobacteria
PTDC/BIA-MIC/2779/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Ambiguity and virulence in a human pathogen
PTDC/BBB-BEP/0695/2012
Researcher
Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Bioprospecção de enzimas com capacidade de degradar biomassa vegetal no metagenoma do sistema divestivo de Porcellio dilatatus Crustacea,Isopoda.
PTDC/AGR-TEC/3789/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2014 Unravelling the early steps in the biosynthesis of the mycobacterial MGLP
Grant 120123
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Mizutani Foundation for Glycoscience
Concluded
2011 - 2014 Pathway for the synthesis of the mycobacterial MGLP. Biochemical and structural characterization of the key enzymes
PTDC/BIA-PRO/110523/2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013 The enigmatic mycobacterial maltokinase
PTDC/BIA-BCM/112459/2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 Characterization and evolution of a rare glycosyltransferase from antitumor producing bacteria of the genus Actinosynnema
Acordo Cultural 2010 Eslováquia 124626903612592
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Ústav molekulárnej biológie Slovenskej akadémie vied, Slovakia
 Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2010 Cloning, expression and regulation of genes for the synthesis of compatible solutes in Thermus thermophilus
Acção Nº E-9/08
Researcher
Universidade de Coimbra, Portugal

Centro de Biología Molecular Severo Ochoa, Spain
 Conselho de Reitores das Universidades Portuguesas, Portugal
Concluded
2008 - 2010 HOTMETAL- Exploiting marine hydrothermal spots for diversity of metal resistance-strategies together with antibiotic resistance dissemination
PTDC/MAR/109057/2008
Researcher
IMAR - Centro Interdisciplinar de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008 Compatible solutes from extremophiles: screening, biosynthesis and heterologous production
POCI/V.5/A0005/2005
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008 Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp.
POCI/BIA-MIC/56511/2004
Researcher
Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2006 O Mundo dos Micróbios - Colecção Portuguesa de Bactérias (CPB) e Laboratório Acreditado de Controlo Microbiológico
REEQ/851/BIO/2005
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2006 Hotsolutes: New applications for compatible solutes from Extremophiles
COOP-CT-2003-508644
Post-doc Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
 European Commission
Concluded
2002 - 2004 Hypersolutes: Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes
QLK3-CT-2000-00640
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Commission
Concluded
2001 - 2004 Towards the Utilization of Cell-Reactors for the Production of Mannosylglycerate, an Enzyme Stabilizer from Hyperthermophiles
POCTI/BIO/35715/1999
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999 - 2001 Exploiting solutes from hyperthermophilic organisms for use as enzyme stabilisers
PRAXIS/BIO/12082/1998
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1997 - 1999 Extremophiles as cell factories
BIO4960488
Master Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 European Commission
Concluded

Other

Designation Funders
2026 - 2029 CiBB4Health+: Biomedicine & Biotechnology - drivers of a Healthier Future (Institutional)
CENTRO2030-FEDER-02604300
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 European Regional Development Fund
Ongoing
2025 - 2029 CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional)
UID/04539/2023
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2025 DYNABrain - Dynamic Brain Function: Towards the Understanding and Treatment of Brain Disorders (ERA Chairs - Institutional)
H2020-WIDESPREAD-2018-2020-6, ID: 952422
WIDESPREAD-06-2020 - ERA Chairs
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Commission
Ongoing
2021 - 2025 CIBB - Center for Innovative Biomedicine and Biotechnology - Associate Laboratory (Institutional)
LA/P/0058/2020
10.54499/LA/P/0058/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2023 CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional)
UIDB/04539/2020 and UIDP/04539/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Ana Maranha, Nuno Empadinhas. "Mycobacterial pathways from simple glycosides to fatty acid-sheltering polymethylated polysaccharides". In Carbohydrate Chemistry, Chemical and Biological Approaches, 118-153. United Kingdom: Royal Society of Chemistry, 2025.
    Published • 10.1039/9781837676101-00118
  2. Emanuel Candeias, Daniela Nunes-Costa, A. Raquel Pereira-Santos, João D. Magalhães, Inês Melo-Marques, Betariz Guedes, A; Nuno Empadinhas, Sandra M. Cardoso. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". In Natural Molecules in Neuroprotection and Neurotoxicity, edited by Marcos Oliveira, 747-778. United States: Elsevier Inc., 2024.
    Published • 10.1016/b978-0-443-23763-8.00068-3
  3. Nuno Empadinhas. "Cerveja de precisão e saúde: do intestino ao cérebro". In A Cerveja - Património de Coimbra e do Mundo, edited by coord. Carla Barbosa & Pedro Baptista; Almedina & Praxis. Coimbra, Portugal: Almedina, 2023.
    Published
  4. Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa". In A Saúde no Saber - Um Projeto de Promoção da Literacia em Saúde, edited by Maria João Padez de Castro. Coimbra, Portugal: Imprensa da Universidade de Coimbra, 2023.
    Published
  5. Joana Costa, Nuno Empadinhas, Susana Alarico, Ana Nobre, Luciana Albuquerque, Milton S. da Costa. "The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments". In Marine Enzymes for Biocatalysis, 465-502. Elsevier, 2013.
    Published • 10.1533/9781908818355.3.465
  6. Milton S. Costa, Nuno Empadinhas. "Biosynthesis of the Compatible Solute Mannosylglycerate from Hyperthermophiles to Mesophiles". In Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya, 311-325. Springer Netherlands, 2005.
    Published • 10.1007/1-4020-3633-7_21
  7. Nuno Empadinhas, Zélia Silva, Milton S. da Costa. "Os solutos compatíveis como estratégia de sobrevivência a agressão osmótica". In Biotecnologia - Fundamentos e Aplicações (ISBN: 978-972-757-197-0), edited by Nelson Lima, Manuel Mota, 51-67. Portugal: Lidel, 2003.
    Published
Conference paper
  1. Cardoso SM, Muñoz-Pinto MF, Candeias E, Esteves AR, Maranha A, Melo-Marques I, Magalhães JD, Carneiro DR, Sant'Anna M, P; Nunes-Costa D, Alarico S, Tiago I, Morgadinho A, Lemos J, Figueiredo PN, Januário C, Empadinhas N. "The role of mitochondria in Gut-Brain axis in Parkinson´s Disease". 2024.
    Published • 10.1016/j.bbadis.2024.167366
  2. Silva DF, Candeias E, Esteves AR, Magalhaes JD, Ferreira IL, Rego AC, Empadinhas N; SM Cardoso. "The gut hypothesis for alzheimer's disease: Bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons". Paper presented in 53rd Annual Meeting of the ESCI, Coimbra, 2019.
    Published
  3. Candeias E, Esteves AR, Silva DF, Magalhaes JD, Ferreira IL, Rego AC, Empadinhas N, Cardoso SM. "Pathogen-associated molecular patterns as culprits for mitochondria-driven Parkinson disease neurodegeneration". Paper presented in 53rd Annual Meeting of the ESCI, Coimbra, 2019.
    Published • 10.1117/12.877748
  4. Magalhães JD, Candeias E, Esteves AR, Alarico S, Tiago I, Empadinhas N, Cardoso SM. "Intensive antibiotic administration generates motor deficits and neuronal mitochondria impairment". Paper presented in 53rd Annual Meeting of the ESCI, Coimbra, 2019.
    Published
  5. Cardoso SM, Esteves AR, Silva DF, Candeias E, Empadinhas N. "The role of mitochondria in neuronal innate immunity activation: relevance for Parkinson's disease". Paper presented in 52nd Annual Meeting of the ESCI, Barcelona, 2018.
    Published
  6. Empadinhas N, da Costa MS. "Diversity, distribution and biosynthesis of compatible solutes". Paper presented in Contributions to Science, 2009.
    Published • 10.2436/20.7010.01.65
  7. Empadinhas N, AlbuquerqueL, Costa J, da Costa MS. "A highly divergent MpgS accounts for the synthesis of mannosylglycerate in the gram-positive bacterium Rubrobacter xylanophilus". Paper presented in FEBS Meeting, Budapest, 2005.
    Published
  8. Alarico S, Empadinhas N, Simões C, Mingote A, da Costa MS. "Thermus thermophilus mutant deficient in the synthesis of mannosylglycerate". Paper presented in FEBS Meeting, Budapest, 2005.
    Published
  9. Empadinhas N, Marugg JD, da Costa MS, Santos H. "Biosynthesis of mannosylglycerate in the hyperthermophile pyrococcus horikoshii: characterization of key-enzymes". Paper presented in FEBS Meeting, Lisboa, 2001.
    Published
Conference poster
  1. Empadinhas N. "Co-author of >90 poster communications documenting an interdisciplinary research trajectory spanning extremophile and mycobacterial biology, glycobiology, enzymology, environmental and clinical microbiology, and microbiome mechanisms in chronic disease, with microbiology as the common thread, through collaborative dissemination at national and international meetings.". 2026.
  2. Alarico S, Roxo IC, Fonseca A, Machado D, Maranha A, Tiago I, Duarte R, Empadinhas N. "Mycobacterium appelbergii sp. nov., a novel species isolated from a drinking water fountain in a rural community". Paper presented in 45th Annual Congress of European Society of Mycobacteriology, 22-25 Jun, Lisbon, Portugal, 2025.
  3. Roxo I, Alarico S, Maranha, Fernandes, Alves, Dias, Silva, Ladeira, Tiago I, Duarte R, Empadinhas N. "The drinking water-gut microbiome axis in NTM disease". Paper presented in 45th Annual Congress of European Society of Mycobacteriology, 22-25 Jun, Lisbon, Portugal, 2025.
  4. Maranha A, Baptista L, Dias A, Alarico S, Tiago I, Empadinhas N. "Microbial antagonism against nontuberculous mycobacteria". Paper presented in 45th Annual Congress of European Society of Mycobacteriology, 22-25 Jun, Lisbon, Portugal, 2025.
  5. Ferreira R, Grunho J, Rocha P, Candeias E, Cardoso SM, Alarico S, Empadinhas N, de Sousa HC, Dias AM. "Ionic liquid functionalized non-releasing antibacterial polyurethane-based wound dressings for enhanced chronic wound healing". Paper presented in 7th Iberoamerican Meeting on Ionic Liquids (MIL 2024), 20-22 Nov, Coimbra, Portugal, 2024.
  6. Bento CSA, Alarico S, Empadinhas N, Lopes DL, Villarreal CF, Sousa HC, Braga MEM. "Sterilisation of alginate-gelatine aerogels through an integrated high-pressure and supercritical CO2-based process". Paper presented in 20th European Meeting on Supercritical Fluids, 26-29 May, Maribor, Slovenia, 2024.
  7. Nunes-Costa D, Manso JA, Macedo-Ribeiro S, Pereira PJB, Empadinhas N. "A novel actinobacterial glucosamine kinase family: characterization and structural insights". Paper presented in 7th Iberian Carbohydrate Meeting, 15-17 Jan, Sitges-Barcelona, Spain, 2024.
  8. Bento CSA, Alarico S, Empadinhas N, de Sousa HC, Braga MEM. "An integrated high-pressure and supercritical CO2-based process for sterilization of alginate-gelatin aerogels". Paper presented in VI Iberoamerican Conference on Supercritical Fluids, 29 Oct - 2 Nov, Córdoba, Argentina, 2023.
  9. Pereira-Santos AR, Candeias E, Esteves AR, Magalhães JD, Nunes-Costa D, Tiago I, Madeira N, Empadinhas N, Cardoso SM. "Unveiling the role of gut-immune-brain axis in Schizophrenia". Paper presented in ESN-ISN Neurochemistry School, 30 Oct, Faro, Portugal, 2023.
  10. Pereira-Santos AR, Candeias E, Magalhães JD, Esteves AR, Empadinhas N, Cardoso SM. "Neuronal control of microglia through the mitochondria". Paper presented in AD/PD 2023 - International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. Mar 28- Apr 1. Gothenburg, Sweden, 2023.
  11. Magalhães JD, Candeias E, Melo-Marques I, Silva D, Empadinhas N, Cardoso SM. "Evidence for alpha-synuclein involvement in innate immune responses after bacterial infection: implications to PD". Paper presented in AD/PD 2023 - International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. Mar 28 - Apr 1, Gothenburg, Sweden, 2023.
  12. Candeias E, Melo-Marques I, Munoz-Pinto MF, Esteves AR, Magalhães JD, Carneiro DR, Empadinhas N, Cardoso SM. "The gut-immune-brain axis in Parkinson disease". Paper presented in AD/PD 2023 - International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. March 28- April 1, Gothenburg, Sweden, 2023.
  13. Pereira-Santos AR, Candeias E, Esteves AR, Magalhães JD, Nunes-Costa D, Tiago I, Madeira N, Empadinhas N, Cardoso SM. "Unveiling the role of gut dysbiosis in Schizophrenia pathology". Paper presented in FENS-Hertie Winter School in Neuro-immune interactions in health and disease, 29 Jan - 4 Feb, Innsbruck, Austria, 2023.
  14. Bento C, Alarico S, Empadinhas N, de Sousa HC, Braga MEM. "Sequential scCO2 drying and sterilization of alginate-gelatin aerogels". Paper presented in Training School Aerogels for Biomedical Applications, 7-10 Jun, Leuven, Belgium, 2022.
  15. Bento C, Carrelo H, Alarico S, Empadinhas N, Sousa H, Cidade MT; Braga M. "PECs-based hydrogels: Physicochemical, microbiological and rheological characterization". Paper presented in AERC 2022 - Annual European Rheology Conference, and IBEREO 2022 - VIII Iberian Meeting on Rheology, 26-28 Apr, Seville, Spain, 2022.
  16. Bento C, Alarico S, Empadinhas N, de Sousa HC, Braga MEM. "Sequential scCO2 drying and sterilisation of alginate-gelatine polyelectrolyte complexes (PECs)". Paper presented in EIFS 2022, 2nd Iberian Meeting on Supercritical Fluids, 28 Feb - 2 Mar, Coimbra, Portugal, 2022.
  17. Magalhães JD, Silva DF, Melo-Marques I, Candeias EM, Empadinhas N, Cardoso SM. "Listeria monocytogenes infection paradigm to “gut-first PD”". Paper presented in BEB Day 2022 – The Overview Effect, 18-19 Jan, Coimbra, Portugal, 2022.
  18. Matos G, Nunes-Costa D, Pinto D, Dias RP, Lopes SC, Silva JL, Nunes PG, Martins CS, Justi FVG; Alarico S, Tiago I, Raposo RS, Santos FA, Alvarez-Leite J, Empadinhas N, Oriá R. "Effects of methylmercury intoxication on gut microbiota, intestinal barrier, and oxidative stress in C57BL/6J mice fed a high-fat diet". Paper presented in 8th World Congress on Targeting Microbiota, 20-22 Oct, Paris, France & Online, 2021.
  19. Esteves AR, Munoz-Pinto MF, Candeias E, Silva DF, Magalhães JD, Ferreira IL, Pereira-Santos AR, Rego AC; Empadinhas N, Cardoso SM. "The Parkinson pandemic: a microbial toxin elicits Parkinson's disease-like neurodegeneration". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 9-11 June, Online, 2021.
  20. Magalhães JD, Esteves AR, Munoz-Pinto MF, Silva DF, Empadinhas N, Cardoso SM. "Listeria monocytogenes infection triggers mitochondrial dysfunction and alpha-synuclein expression: relevance to Parkinson's disease". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 9-11 Jun, Online, 2021.
  21. Munoz-Pinto MF, Esteves AR, Magalhães JD, Nunes-Costa D, Candeias E, SIlva D, Alarico S,; Pereira-Santos AR, Reis-Carneiro D, Melo-Marques I, Lemos J, Tiago I, Januário C, Empadinhas N, Cardoso SM. "Parkinson's disease neurodegeneration is mediated by the gut microbiome". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 9-11 Jun, Online, 2021.
  22. Nunes-Costa D, Alarico S, Silva A, Costa M, Macedo-Ribeiro S, Empadinhas N. "A rare thermophilic opportunistic pathogen: mycobacterial growth and viability near pasteurization temperatures". Paper presented in 2º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 31 Jan, Lisboa, Portugal, 2020.
  23. Alarico S, Machado D, Maranha A, Costa M, Roxo I, Tiago I, Duarte R, Empadinhas N. "Nontuberculous mycobacteria from water of infected patients' homes". Paper presented in 2º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 31 Jan, Lisboa, Portugal, 2020.
  24. Maranha A, Costa M, Correia-Neves M, Empadinhas N. "Differential distribution of polymethylated polysaccharides in mycobacteria". Paper presented in MycoPORTO, 20 Sep, ICBAS, Porto, Portugal, 2019.
  25. Silva DF, Candeias E, Esteves AR, Magalhães JD, Empadinhas N, Cardoso SM. "The gut hypothesis for Alzheimer's Disease: bacterial metabolites cause bioenergetics failure and activate innate immunity in cortical neurons". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 22-24 May, Coimbra, Portugal, 2019.
  26. Candeias E, Esteves AR, Silva DF, Magalhães JD, Empadinhas N, Cardoso SM. "Pathogen-associated molecular patterns as culprits for mitochondria-driven Parkinson's Disease neurodegeneration". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 22-24 May, Coimbra, Portugal, 2019.
  27. Magalhães JD, Candeias E, Esteves AR, Alarico S, Tiago I, Empadinhas N, Cardoso SM. "Intensive antibiotic administration generates motor deficits and neuronal mitochondrial impairment". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 22-24 May, Coimbra, Portugal, 2019.
  28. Candeias E, Esteves AR, Magalhães JD, Silva DF, Costa H, Alarico S, Ferreira I, Rego AC, Empadinhas N, Cardoso SM. "The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease". Paper presented in 1st CIBB Neuroscience and Disease Retreat, 10 May, Miranda do Corvo, Portugal, 2019.
  29. Frade J, Reis T, Alarico S, Empadinhas N, Chaves C, Rodrigues F. "Brain tumor? A Nocardia abscessus brain abscess clinical case". Paper presented in 29th European Congress of Clinical Microbiology Infectious Diseases (ECCMID), 16-19 Apr, Amsterdam, The Netherlands, 2019.
  30. Maranha A, Alarico S, Tiago I, Cardoso O, Pereira SG, Empadinhas N. "Microbiome signatures of diabetic skin and ulcers: combining drug resistance with culture and NGS approaches". Paper presented in 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 13-16 Apr, Amsterdam, The Netherlands, 2019.
  31. Esteves AR, Candeias E, Silva DF, Magalhães J, Empadinhas N, Cardoso SM. "Mitochondria as a probable target of a bacterial neurotoxin: relevance to Parkinson's disease etiology". Paper presented in The 14th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD), 26-31 Mar, Lisboa, Portugal, 2019.
  32. Silva DF, Candeias E, Esteves AR, Magalhães JD, Empadinhas N, Cardoso SM. "Cortical neurons exposed to bacterial metabolites develop Alzheimer´s disease-related hallmarks". Paper presented in The 14th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD), 26-31 Mar, Lisboa, Portugal, 2019.
  33. Candeias E, Esteves AR, Magalhães JD, Empadinhas N, Cardoso SM. "Chronic antibiotic treatment induces neurodegenerative features through the mitochondria". Paper presented in The 14th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD), 26-31 Mar, Lisboa, Portugal, 2019.
  34. Maranha A, Alarico S, Leal E, Carvalho E, Pereira SG, Empadinhas N. "Projeto Microcare: o impacto microbiano na pele e ferida diabética e seus potenciais". Paper presented in 15º Congresso Português de Diabetes, 8-10 Mar, Vilamoura, Portugal, 2019.
  35. Maranha A, Alarico S, Cardoso O, Pereira SG, Empadinhas N. "Diabetic foot ulcers: the challenges of multidrug resistance and the possibilities interspecies competition may offer". Paper presented in ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, Lisbon, Portugal, 2018.
  36. Costa M, Miranda V, Sequeira A, Ripoll-Rozada J, Maranha A, Pereira PJB, Ventura MR, Empadinhas N. "A key mannosyltransferase for elongation of mycobacterial MMP: chemical synthesis of mannosides and enzyme properties". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 18 Jun, Coimbra, Portugal, 2018.
  37. Maranha A, Costa M, Correia-Neves M, Empadinhas N. "Large-scale purification of mycobacterial polymethylated polysaccharides". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 18 Jun, Coimbra, Portugal, 2018.
  38. Ripoll-Rozada J, Costa M, Manso J, Maranha A, Miranda V, Sequeira, Ventura R, Macedo-Ribeiro S, Pereira P, Empadinhas N. "Unveiling mycobacterial methylmannose polysaccharide biosynthesis: a unique 1-methyltransferase specific for 3-methylated mannosides". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 18 Jun, Coimbra, Portugal, 2018.
  39. Alarico S, Pereira SG, Maranha A, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Empadinhas N. "Rare mycobacteria isolated from a hospital environment and skin of diabetic patients: antimicrobial resistance profiling". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 18 Jun, Coimbra, Portugal, 2018.
  40. Manso JA, Nunes-Costa D, Empadinhas N, Pereira PJB. "Insights into a structural homologue of mycobacterial maltokinases with potential implications in antibiotic production". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal, 18 Jun, Coimbra, Portugal, 2018.
  41. Alarico S, Pereira SG, Maranha A, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Empadinhas N. "Antimicrobial resistance in rare mycobacteria from a hospital environment and diabetic foot ulcers". Paper presented in V International Conference on Antimicrobial Research, 24-25 May, Torremolinos, Spain, 2018.
  42. Silva DF, Esteves AR, Candeias E, Empadinhas N, Cardoso SM. "The neurotoxin ß-methylamino-L-alanine (BMAA) acts on mitochondria to recapitulate PD-related pathology". Paper presented in 8th World Congress on Targeting Mitochondria, 23-24 Oct, Berlin, Germany, 2017.
  43. Cereija T, Alarico S, Lourenço EC, Ventura MR, Empadinhas N, Pereira PJB. "Biochemical and structural characterization of a mycobacterial GG hydrolase, a key enzyme in nitrogen starvation recovery". Paper presented in XIX National Congress of Biochemistry, 8-10 Dec, Guimarães, Portugal, 2016.
  44. Cereija T, Lourenço EC, Ventura MR, Empadinhas N, Pereira PJB. "Structural characterization of glucosylglycerate hydrolase from Mycobacterium hassiacum". Paper presented in i3S Annual Meeting 2016, 6 Oct, Porto, Portugal, 2016.
  45. Silva A, Sanctis D, Alarico S, Empadinhas N, Pereira PJB, Macedo-Ribeiro S. "Molecular details of Mycobacterium hassiacum GpgS, a key enzyme in methylglucose lipopolysaccharide biosynthesis". Paper presented in Instruct Biennial Structural Biology Meeting, 20–22 May, Florence, Italy, 2015.
  46. Fraga J, Silva A, Maranha A, Alarico S, Mendes V, Empadinhas N, Pereira PJB, Macedo-Ribeiro S. "Molecular details of sugar biosynthesis in mycobacteria". Paper presented in IUCr 2014 - The 23rd Congress General Assembly International Union of Crystallography, 5-12 Aug, Montréal, Canada, 2014.
  47. Empadinhas N, Maranha A, Mendes V, Costa M, Nunes-Costa D, Alarico S. "Deciphering a novel metabolic pathway in mycobacteria toward advanced therapies and diagnosis of tuberculosis and emerging mycobacterial infections". Paper presented in Hovione & MIT Portugal Symposium, 30 Jun, Lumiar, Lisboa, Portugal, 2014.
  48. Maranha A, Moynihan PJ, Ventura MR, et al., Macedo-Ribeiro S, Clarke AJ, Empadinhas N. "Identification and functional characterization of a novel essential acyltransferase, a potential target for the design of new drugs against XDR-TB". Paper presented in XI CNC Annual Meeting, 17-19 Dec, Biocant, Cantanhede, Portugal, 2013.
  49. Farias P, Gama F, Empadinhas N, Almeida AM, Morais PV. "Hospital's environmental microbial communities: a survey in two hospitals with different dimensions". Paper presented in Microbiotec13, Portuguese Congress of Microbiology & Biotechnology, 6-8 Dec, Aveiro, Portugal, 2013.
  50. Maranha A, Alarico S, Costa M, Lamaroso A, Nunes-Costa D, Lourenço E, Ventura MR, Mendes V, Empadinhas N. "The early steps in mycobacterial MGLP biosynthesis: the players". Paper presented in EuroCarb17, 17th European Carbohydrate Symposium, 7-11 Jul, Tel-Aviv, Israel, 2013.
  51. Alarico S, Maranha A, Costa M, Lourenço E, Ventura MR, Empadinhas N. "The mycobacterial glucosylglycerate hydrolase GGH is restricted to rapidly-growing species". Paper presented in 2nd International Conference on Antimicrobial Research, 21-23 Nov, Lisboa, Portugal, 2012.
  52. Maranha A, Lamaroso A, Alarico S, Mendes V, Empadinhas N. "Biochemical studies of maltokinases from mycobacteria and pseudomonads". Paper presented in 2nd International Conference on Antimicrobial Research, 21-23 Nov, Lisboa, Portugal, 2012.
  53. Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJB, Empadinhas N. "Genome sequence of Mycobacterium hassiacum, an exceptional source of heat stable mycobacterial proteins toward structure-guided drug discovery". Paper presented in 2nd International Conference on Antimicrobial Research, 21-23 Nov, Lisboa, Portugal, 2012.
  54. Fraga J, Mendes V, Maranha A, Almeida B, Fernandes S, Empadinhas N, Macedo-Ribeiro S, Pereira PJB. "Sugar biosynthesis in mycobacteria: a structural roadmap". Paper presented in 37th FEBS Congress and 22nd IUBMB Congress, 4-9 Sep, Sevilla, Spain, 2012.
  55. Alarico S, Empadinhas N, da Costa MS. "A new bacterial hydrolase specific for compatible solutes mannosylglycerate and glucosylglycerate". Paper presented in Microbiotec11, 1-3 Dec, Braga, Portugal, 2011.
  56. Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N. "New insights into the biosynthesis of the mycobacterial MGLP arising from identification of a novel GpgP". Paper presented in Microbiotec11, 1-3 Dec, Braga, Portugal, 2011.
  57. Mendes V, Maranha A, Costa M, da Costa MS, Empadinhas N. "Comparative studies on mycobacterial maltokinases: saprophytes versus pathogens". Paper presented in 8th International Conference on the Pathogenesis of Mycobacterial Infections, 30 Jun-3 Jul, Stockholm, Sweden, 2011.
  58. Empadinhas N, Pereira PJB, Albuquerque L, Costa J, Sá-Moura B, Macedo-Ribeiro S, da Costa MS. "Functional and structural characterization of a paradoxical glucosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus involved in mannosylglycerate synthesis in vivo". Paper presented in Extremophiles 2010, International Congress on Extremophiles, 12-16 Sep, Ponta Delgada, Açores, Portugal, 2010.
  59. Mendes V, Maranha A, Carmona V, Alarico S, da Costa MS, EmpadinhasN. "Identification of genes and characterization of enzymes for the biosynthesis of polysaccharides in Mycobacterium tuberculosis". Paper presented in Ciência 2010, 4-7 Jul, Lisboa, Portugal, 2010.
  60. Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS. "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". Paper presented in Feira da Ciência e Tecnologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 22-24 Mar, Coimbra, Portugal, 2010.
  61. Mendes V, Maranha A, Lamosa P, da Costa MS, Empadinhas N. "Biochemical characterization of maltokinase from Mycobacterium tuberculosis". Paper presented in Feira da Ciência e Tecnologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 22-24 Mar, Coimbra, Portugal, 2010.
  62. Fernandes C, Mendes V, Costa J, Empadinhas N, Lamosa P, Borges N, Santos H, da Costa MS. "Mannosyl-alpha-1,2-glucosylglycerate synthesis in Petrotoga mobilis: identification of genes and characterization of enzymes". Paper presented in 3rd FEMS Congress of European Microbiologists, 28 Jun-2 Jul, Goteborg, Sweden, 2009.
  63. Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS. "A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: the first bacterial TreT". Paper presented in XVI National Congress of Biochemistry, 22-25 Oct, Ponta Delgada, Açores, Portugal, 2008.
  64. Fernandes C, Empadinhas N, Mendes V, Costa J, Santos H, da Costa MS. "Petrotoga mobilis possesses two pathways for synthesis of the rare compatible solute mannosyl-alpha-1,2-glucosylglycerate". Paper presented in XVI National Congress of Biochemistry, 22-25 Oct, Ponta Delgada, Açores, Portugal, 2008.
  65. Pereira PJB, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S. "Mycobacterium tuberculosis GpgS: structural characterization of a key enzyme in MGLP biosynthesis". Paper presented in XVI National Congress of Biochemistry, 22-25 Oct, Ponta Delgada, Açores, Portugal, 2008.
  66. Nobre A, Alarico S, Empadinhas N, da Costa MS. "Two pathways for synthesis of trehalose in Rubrobacter xylanophilus, an ancient desiccation-resistant thermophilic bacterium". Paper presented in MicroBiotec'2007, Congresso Nacional de Microbiologia, Biotecnologia e Genética, 30 Nov-2 Dec, Lisboa, Portugal, 2007.
  67. Costa J, Empadinhas N, da Costa MS. "The thermophilic bacterium Persephonella marina uses a two-step pathway for the synthesis of glucosylglycerate". Paper presented in 2nd FEMS Congress of European Microbiologists, 4-8 Jul, Madrid, Spain, 2006.
  68. Fernandes C, Empadinhas N, da Costa MS. "The inositol-1-phosphate synthase from Rubrobacter xylanophilus". Paper presented in 2nd FEMS Congress of European Microbiologists, 4-8 Jul, Madrid, Spain, 2006.
  69. Nobre A, Empadinhas N, Alarico S, da Costa MS. "Trehalose synthesis in the radiation-resistant bacterium Rubrobacter xylanophilus. Cloning, expression and properties of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase". Paper presented in 2nd FEMS Congress of European Microbiologists, 4-8 Jul, Madrid, Spain, 2006.
  70. Alarico S, Empadinhas N, da Costa MS. "An extremely thermostable trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27". Paper presented in 2nd FEMS Congress of European Microbiologists, 4-8 Jul, Madrid, Spain, 2006.
  71. Empadinhas N, Mendes V, Simões C, Mingote A, Lamosa P, Santos H, da Costa MS. "Compatible solutes in the radiation-resistant bacterium Rubrobacter xylanophilus". Paper presented in 2nd FEMS Congress of European Microbiologists, 4-8 Jul, Madrid, Spain, 2006.
  72. Empadinhas N, Simões C, Mingote A, Lamosa P, Santos H, da Costa MS. "Accumulation of compatible solutes in the extremely radiation-resistant bacterium Rubrobacter xylanophilus". Paper presented in MICRO'05 and BIOTECH'05, Congressos Nacionais de Microbiologia e Biotecnologia, 30 Nov-2 Dec, Varzim, Portugal, 2005.
  73. Costa J, Empadinhas N, da Costa MS. "Elucidation of the biosynthetic pathway of glucosylglycerate. Characterization of key-enzymes". Paper presented in 30th FEBS Congress: The Protein World, 2-7 Jul, Budapest, Hungary, 2005.
  74. Empadinhas N, Albuquerque L, Costa J, da Costa MS. "A highly divergent MpgS accounts for mannosylglycerate synthesis in the gram-positive bacterium Rubrobacter xylanophilus". Paper presented in 30th FEBS Congress: The Protein World, 2-7 Jul, Budapest, Hungary, 2005.
  75. Alarico S, Empadinhas N, Simões C, Mingote A, da Costa MS. "Thermus thermophilus mutant deficient in synthesis of mannosylglycerate". Paper presented in 30th FEBS Congress: The Protein World, 2-7 Jul, Budapest, Hungary, 2005.
  76. Costa J, Empadinhas N, Santos MAS, Schleper C, da Costa MS. "Biosynthesis of mannosylglycerate in crenarchaeota". Paper presented in Extremophiles 2004, The 5th International Conference on Extremophiles, 19-23 Sep, Maryland, USA, 2004.
  77. Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MAS, Santos H, da Costa MS. "A gene from Dehalococcoides ethenogenes encodes a bifunctional mannosylglycerate synthase: the first enzyme for the synthesis of mannosylglycerate at low temperatures". Paper presented in Halophiles 2004, International Congress on Halophilic Microorganisms, 4-9 Sep, Ljublana, Slovenia, 2004.
  78. Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MAS, Santos H, da Costa MS. "A bifunctional mannosylglycerate synthase from Dehalococcoides ethenogenes: synthesis of mannosylglycerate at low temperature". Paper presented in MICRO 2003, Congresso Nacional de Microbiologia, 29 Nov-2 Dec, Tomar, Portugal, 2003.
  79. Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS. "The bacterium Thermus thermophilus uses a 2-step pathway for the synthesis of mannosylglycerate". Paper presented in Gordon Research Conference on Cellular Osmoregulation: Sensors, Transducers and Regulators, 10-15 Aug, Bristol, USA, 2003.
  80. Santos P, Pinhal I, Rainey FA, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A, da Costa MS. "Two gamma-proteobacteria, grow in protozoa and require charcoal for growth in laboratory media. Description of Aquicella lusitana gen. nov., sp. nov. and Aquicella siphonis, sp. nov.". Paper presented in 1st FEMS Congress of European Microbiologists, 29 Jun-3 Jul, Ljubljana, Slovenia, 2003.
  81. Empadinhas N, Albuquerque L, Henne A, da Costa MS, Santos H. "The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for synthesis of mannosylglycerate". Paper presented in 1st FEMS Congress of European Microbiologists, 29 Jun-3 Jul, Ljubljana, Slovenia, 2003.
  82. Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. "Biochemical and genetic characterization of the two-step pathway for the synthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus". Paper presented in 1st FEMS Congress of European Microbiologists, 29 Jun-3 Jul, Ljubljana, Slovenia, 2003.
  83. Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. "Biochemical and genetic characterization of the phosphorylating pathway for the synthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus". Paper presented in Extremophiles 2002, 4th International Congress on Extremophiles, 22-26 Sep, Naples, Italy, 2002.
  84. Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS. "Biosynthesis of mannosylglycerate in Thermus thermophiles: Gene organization and properties of enzymes". Paper presented in Extremophiles 2002, 4th International Congress on Extremophiles, 22-26 Sep, Naples, Italy, 2002.
  85. Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: biochemical and genetic characterization of key-enzymes". Paper presented in MICRO 2001, Congresso Nacional de Microbiologia, 5-8 Dec, Póvoa de Varzim, Portugal, 2001.
  86. Empadinhas N, Marugg JD, da Costa MS, Santos H. "Biosynthesis of mannosylglycerate in the hyperthermophile Pyrococcus horikoshii: characterization of key-enzymes". Paper presented in 27th Meeting of the Federation of European Biochemical Societies (FEBS), 30 Jun-5 Jul, Lisboa, Portugal, 2001.
  87. Alarico S, Empadinhas N, Nobre MF, Rainey FA, da Costa MS. "Characterization of a slightly thermophilic aerobic bacterium gen. nov., sp. nov. Isolated from a hot spring". Paper presented in XVIII Congresso de la Sociedad Española de Microbiología, Alicante, Spain, 2001.
  88. Marugg JD, Empadinhas N, Ferreira C, Miguel C, Martins LO, Santos H, da Costa MS. "Cloning and expression of the genes involved in compatible solute biosynthesis in Rhodothermus marinus and Thermus thermophilus". Paper presented in MICRO'99, Congresso Nacional de Microbiologia, 1-4 Dec, Luso, Portugal, 1999.
  89. Marugg JD, Empadinhas N, Ferreira C, Miguel C, Martins LO, Santos H, da Costa MS. "The genes involved in compatible solute biosynthesis in Rhodothermus marinus and Thermus thermophilus". Paper presented in 3rd Meeting "Extremophiles as Cell Factories", 3-6 Jun, Graz, Austria, 1999.
  90. Martins LO, Empadinhas N, da Costa MS, Santos H. "Pathway for the synthesis of mannosylglycerate in Rhodothermus marinus: purification and characterization of mannosylglycerate synthase". Paper presented in XI Meeting of the Portuguese Biochemical Society, 28-30 Nov, Tomar, Portugal, 1998.
  91. Marugg JD, Empadinhas N, Miguel C, Martins LO, Santos H, da Costa MS. "Molecular cloning of genes involved in compatible solute biosynthesis in Rhodothermus marinus and Thermus thermophilus". Paper presented in International Conference "Thermophiles 98", 6-11 Sep, Brest, France, 1998.
  92. Martins LO, Empadinhas N, da Costa MS, Santos H. "Pathway for the synthesis of mannosylglycerate in Rhodothermus marinus: purification and characterization of mannosylglycerate synthase". Paper presented in International Conference "Thermophiles 98", 6-11 Sep, Brest, France, 1998.
  93. Marugg JD, Empadinhas N, Miguel C, Santos H, da Costa MS. "Identification of genes involved in compatible solute biosynthesis in Rhodothermus marinus and Thermus thermophilus". Paper presented in 2nd Meeting "Extremophiles as Cell Factories", 18-21 Apr, Dublin, Ireland, 1998.
  94. Martins LO, Empadinhas N, da Costa MS, Santos H. "Pathway for the synthesis of mannosylglycerate in Rhodothermus marinus: purification and characterization of mannosylglycerate synthase". Paper presented in 2nd Meeting "Extremophiles as Cell Factories", 18-21 Apr, Dublin, Ireland, 1998.
Journal article
  1. Pereira-Santos AR, Jesus-Faria S, Candeias E, Maranha A, Santos P, Empadinhas N, Cardoso SM. "Mucosal microbiota and intraepithelial lymphocytes remodeling links maternal immune activation to sex-specific neuroimmune trajectories". (2026):
    In press
  2. Nunes-Costa D, Silva A, Alarico S, Manso JA, Empadinhas N, Pereira PJB, Macedo-Ribeiro S. "A cryptic aromatic binding pocket in the highly thermostable GpgS from Mycobacterium hassiacum hints at MGLP pathway crosstalk". Protein Science (2026): https://doi.org/10.1002/pro.70713.
    Published • 10.1002/pro.70713
  3. Maranha A, Leal EC, Alarico S, Tiago SG, Pereira SG, Empadinhas N, Carvalho E. "Neuropeptides neurotensin and substance P accelerate diabetic wound healing by modulating immunity and the skin microbiome". Scientific Reports (2026): https://doi.org/10.1038/s41598-025-30723-w.
    Published • 10.1038/s41598-025-30723-w
  4. Abreu AE, Empadinhas N, Cardoso SM. "Unveiling butyrate as a Parkinson's disease therapy". Neuroscience Bulletin 42 1 (2026): 233-246. https://doi.org/10.1007/s12264-025-01498-x.
    Published • 10.1007/s12264-025-01498-x
  5. Bento CSA, Lopes DL, Villarreal CF, Empadinhas N, Alarico S, de Sousa HC, Braga MEM. "Shelf-life of sterilised alginate-gelatine aerogels developed through an integrated high-pressure and supercritical CO2 process". The Journal of Supercritical Fluids 228 (2025): 106781. https://doi.org/10.1016/j.supflu.2025.106781.
    Published • 10.1016/j.supflu.2025.106781
  6. Bento CSA, Ruivo JP, Alarico S, Empadinhas N, Candeias, Cardoso SM, de Sousa HC, Dias AMA, Braga MEM. "Eco-friendly development of sterile chitosan-based aerogels for wound dressing applications using integrated scCO2 processing". International Journal of Pharmaceuticals (2025): https://doi.org/10.1016/j.ijpharm.2025.126021.
    Published • 10.1016/j.ijpharm.2025.126021
  7. Roxo IC, Alarico S, Fonseca A, Machado D, Maranha A, Tiago I, Duarte R, Empadinhas N. "Mycobacterium appelbergii sp. nov., a novel species Isolated from a drinking water fountain in a rural community". Microorganisms 3 (2025): https://www.mdpi.com/2076-2607/13/6/1259.
    Published • 10.3390/ microorganisms13061259
  8. Matos GA, Nunes-Costa D, Pinto DV, Martins CS, Silva JL, Leocadio PCL, Andrade MER, Raposo RS, Tiago I, Alarico S, Santo; Cardoso VN, Santos FA, Alvarez-Leite JI, Empadinhas N, Oriá RB. "Methylmercury chronic exposure and a high-fat diet induce gut microbiome alterations and intestinal barrier disruption in mice". Environmental Toxicology (2025): http://doi.org/10.1002/tox.24469.
    Published • 10.1002/tox.24469
  9. Sobral J, Empadinhas N, Esteves AR, Cardoso SM. "Impact of nutrition on gut microbiota: Implications for Parkinson’s Disease". Nutrition Reviews (2025): https://doi.org/10.1093/nutrit/nuae208.
    Published • 10.1093/nutrit/nuae208
  10. Munoz-Pinto MF, Candeias E, Melo-Marques I, Esteves AR, Maranha A, Magalhães JD, Carneiro DR, Sant'Anna M; Pereira-Santos AR, Abreu AE, Nunes-Costa D, Alarico S, Tiago I, Morgadinho A, Lemos J, Figueiredo PN, Januário C; Empadinhas N, Cardoso SM. "Gut-first Parkinson's disease is encoded by gut dysbiome". Molecular Neurodegeneration 19 (2024): https://doi.org/10.1186/s13024-024-00766-0.
    Published • 10.1186/s13024-024-00766-0
  11. Bento C, Lopes D, Villarreal C, Empadinhas N, Alarico S, de Sousa HC, Braga MEM. "Integrated processes (HPSE+scCO2) to prepare sterilized alginate-gelatine-based aerogel". International Journal of Pharmaceutics 662 (2024): 124546. http://dx.doi.org/10.1016/j.ijpharm.2024.124546.
    Published • 10.1016/j.ijpharm.2024.124546
  12. Melo-Marques I, Cardoso SM, Empadinhas N. "Bacterial extracellular vesicles at the interface of gut microbiota and immunity". Gut Microbes 16 1 (2024): https://doi.org/10.1080/19490976.2024.2396494.
    Published • 10.1080/19490976.2024.2396494
  13. Antoniuk O, Maranha A, Salvador J, Empadinhas N, Moreira V. "Bi- and tricyclic diterpenoids: landmarks from a decade (2013–2023) in search of leads against infectious diseases". Natural Product Reports (2024): http://dx.doi.org/10.1039/d4np00021h.
    Published • 10.1039/d4np00021h
  14. Maranha A, Alarico S, Nunes-Costa D, Melo-Marques I, Roxo I, Castanheira P, Caramelo O, Empadinhas N. "Drinking water microbiota, entero-mammary pathways, and breast cancer: Focus on nontuberculous mycobacteria". Microorganisms 12 7 (2024): 1425. http://dx.doi.org/10.3390/microorganisms12071425.
    Published • 10.3390/microorganisms12071425
  15. Candeias E, Pereira-Santos AR, Empadinhas N, Cardoso SM, Esteves AR. "The Gut-Brain Axis in Alzheimer’s and Parkinson’s Diseases: The Catalytic Role of Mitochondria". Journal of Alzheimer's Disease (2024): 1-17. http://dx.doi.org/10.3233/jad-240524.
    Published • 10.3233/jad-240524
  16. Pereira-Santos AR, Candeias E, Magalhães JD, Empadinhas N, Esteves AR, Cardoso SM. "Neuronal control of microglia through the mitochondria". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024): 167167. http://dx.doi.org/10.1016/j.bbadis.2024.167167.
    Published • 10.1016/j.bbadis.2024.167167
  17. Magalhães JD, Candeias E, Melo-Marques I, Abreu AE, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "Nocardia cyriacigeorgica elicits gut disturbances in a leaky gut model of colitis, but not the harmful cascade leading to gut-first Parkinson’s Disease". International Journal of Molecular Sciences 25 6 (2024): 3423. https://www.mdpi.com/1422-0067/25/6/3423.
    Published • 10.3390/ijms25063423
  18. Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. "Gut-brain-axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine". Veterinary Medicine International 2024 2856759 (2024): https://doi.org/10.1155/2024/2856759.
    Published • 10.1155/2024/2856759
  19. Bento CSA, Carrelo H, Alarico S, Empadinhas N, de Sousa HC, Cidade MT, Braga MEM. "Effect of ScCO2 on the decontamination of PECs-based cryogels: a comparison with H2O steam and H2O2 nebulization methods". International Journal of Pharmaceutics (2023): 123451. http://dx.doi.org/10.1016/j.ijpharm.2023.123451.
    Published • 10.1016/j.ijpharm.2023.123451
  20. Coimbra P, Alarico S, Empadinhas N, Braga MEM, Gaspar MC. "Sustainable starch-based edible films with agrifood residues as potential carriers for the probiotic Lactobacillus rhamnosus". Innovative Food Science & Emerging Technologies 88 (2023): 103452. http://dx.doi.org/10.1016/j.ifset.2023.103452.
    Published • 10.1016/j.ifset.2023.103452
  21. Magalhães JD, Candeias E, Melo-Marques I, Silva DF, Esteves AR, Empadinhas N, Cardoso SM. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinsons disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3.
    Published • 10.1007/s00018-023-04819-3
  22. Magalhães JD, Esteves AR, Candeias E, Silva DF, Empadinhas N, Cardoso SM. "The role of bacteria-mitochondria communication in the activation of neuronal innate immunity: Implications to Parkinson's Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339.
    Published • 10.3390/ijms24054339
  23. Maranha A, Costa M, Ripoll-Rozada J, Manso JA, Miranda V, Mendes V, Manadas B, Macedo-Ribeiro S, Ventura MR; Pereira PJB, Empadinhas N. "Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides". Communications Biology 6 1 (2023): 108. https://doi.org/10.1038/s42003-023-04448-3.
    Published • 10.1038/s42003-023-04448-3
  24. Esteves AR, Muñoz-Pinto MF, Nunes-Costa D, Candeias E, Silva DF, Magalhães JD, Pereira-Santos AR, Ferreira IL; Alarico S, Tiago I, Empadinhas N, Cardoso SM. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut 72 1 (2023): 73-89. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    Published • 10.1136/gutjnl-2021-326023
  25. Costa HN, Esteves AR, Empadinhas N, Cardoso SM. "Parkinson's Disease: a multisystem disorder". Neuroscience Bulletin 39 1 (2023): 113-124. http://dx.doi.org/10.1007/s12264-022-00934-6.
    Published • 10.1007/s12264-022-00934-6
  26. Silva DF, Empadinhas N, Cardoso SM, Esteves AR. "Neurodegenerative microbially-shaped diseases: oxidative stress meets neuroinflammation". Antioxidants 11 11 (2022): 2141. http://dx.doi.org/10.3390/antiox11112141.
    Published • 10.3390/antiox11112141
  27. Bento C, Alarico S, Empadinhas N, Sousa HC, Braga MEM. "Sequential scCO2 drying and sterilisation of alginate-gelatine aerogels for biomedical applications". The Journal of Supercritical Fluids 184 (2022): 105570. http://dx.doi.org/10.1016/j.supflu.2022.105570.
    Published • 10.1016/j.supflu.2022.105570
  28. Gonçalves S, Nunes-Costa D, Cardoso SM, Empadinhas N, Marugg JD. "Enzyme promiscuity in serotonin biosynthesis, from bacteria to plants and humans". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.873555.
    Published • 10.3389/fmicb.2022.873555
  29. Muñoz-Pinto MF, Empadinhas N, Cardoso SM. "The neuromicrobiology of Parkinson's disease: A unifying theory". Ageing Research Reviews 70 (2021): 101396. http://dx.doi.org/10.1016/j.arr.2021.101396.
    Published • 10.1016/j.arr.2021.101396
  30. Gonçalves AM, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "The Mitochondrial Ribosome: A world of opportunities for mitochondrial dysfunction toward Parkinson's Disease". Antioxidants & Redox Signaling 34 8 (2021): 694-711. https://www.liebertpub.com/doi/10.1089/ars.2019.7997.
    Published • 10.1089/ars.2019.7997
  31. Mouritzen MV, Petkovic M, Qvist K, Poulsen SS, Alarico S, Leal EC, Dalgaard LT, Empadinhas N, Carvalho E, Jenssen H. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy - Methods & Clinical Development 20 (2021): 726-739. https://doi.org/10.1016/j.omtm.2021.02.008.
    Published • 10.1016/j.omtm.2021.02.008
  32. Silva DF, Candeias E, Esteves AR, Magalhães JD, Ferreira IL, Nunes-Costa D, Rego AC, Empadinhas N, Cardoso SM. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation and Alzheimer's disease features in cortical neurons". Journal of Neuroinflammation 17 332 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y.
    Published • 10.1186/s12974-020-02004-y
  33. Oriá RB, Empadinhas N, Malva JO. "Editorial: Interplay between nutrition, the intestinal microbiota and the immune system". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.01758.
    Published • 10.3389/fimmu.2020.01758
  34. Alarico S, Nunes-Costa D, Silva A, Costa M, Macedo-Ribeiro S, Empadinhas N. "A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures". Microbiology 166 5 (2020): 474-483. http://dx.doi.org/10.1099/mic.0.000898.
    Published • 10.1099/mic.0.000898
  35. Silva MB, Lepzienj R, Ols S, Dahlbergh B, Grunewaldh J, Lore K, Smed-Sörensen A, Correia-Neves M, Empadinhas N; Färnert A, Källenius G, Sundling C. "Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers". Journal of Immunological Methods 481 (2020): 112792. http://dx.doi.org/10.1016/j.jim.2020.112792.
    Published • 10.1016/j.jim.2020.112792
  36. Nunes-Costa D, Magalhães JD, G-Fernandes M, Cardoso SM, Empadinhas N. "Microbial BMAA and the pathway for Parkinson's Disease neurodegeneration". Frontiers in Aging Neuroscience 12 (2020): https://doi.org/10.3389/fnagi.2020.00026.
    Published • 10.3389/fnagi.2020.00026
  37. Cereija TB, Alarico S, Lourenço EC, Manso JA, Ventura MR, Empadinhas N, Macedo-Ribeiro S, Pereira PJB. "The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation". IUCrJ 6 4 (2019): 572-585. https://doi.org/10.1107/S2052252519005372.
    Published • 10.1107/S2052252519005372
  38. Tiago I, Alarico S, Maranha A, Coelho C, Pereira SG, Empadinhas N. "High-Quality draft genome sequences of rare nontuberculous mycobacteria isolated from surfaces of a hospital". Microbiology Resource Announcements 8 21 (2019): https://doi.org/10.1128/MRA.00496-19.
    Published • 10.1128/MRA.00496-19
  39. Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB. "Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity". mBio (2019): https://doi.org/10.1128/mBio.00239-19.
    Published • 10.1128/mBio.00239-19
  40. Pereira SG, Alarico S, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Maranha A, Empadinhas N. "Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment". BMC Microbiology 19 1 (2019): http://dx.doi.org/10.1186/s12866-019-1428-4.
    Published • 10.1186/s12866-019-1428-4
  41. Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S,; Pereira PJB; Empadinhas N. "Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides". Proceedings of the National Academy of Sciences (2019): 201813450-201813450. https://www.pnas.org/content/116/3/835.long.
    Published • 10.1073/pnas.1813450116
  42. Cardoso SM, Empadinhas N. "The microbiome-mitochondria dance in prodromal Parkinson's Disease". Frontiers in Physiology 9 (2018): https://www.frontiersin.org/articles/10.3389/fphys.2018.00471/full.
    Published • 10.3389/fphys.2018.00471
  43. Cereija TB, Alarico S, Empadinhas N, Pereira PJB. "Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase". Acta Crystallographica Section F Structural Biology Communications 73 9 (2017): 536-540. https://doi.org/10.1107%2Fs2053230x17012419.
    Published • 10.1107/S2053230X17012419
  44. Pereira SG, Moura J, Carvalho E, Empadinhas N. "Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies". Frontiers in Microbiology 8 (2017): https://doi.org/10.3389%2Ffmicb.2017.01791.
    Published • 10.3389/fmicb.2017.01791
  45. Farias PG, Gama FJ, Reis D, Alarico S, Empadinhas N, Martins JC, Almeida AF, Morais PV. "Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria". Antonie van Leeuwenhoek 110 7 (2017): 863-876. http://dx.doi.org/10.1007/s10482-017-0857-z.
    Published • 10.1007/s10482-017-0857-z
  46. Nunes-Costa D, Maranha A, Costa M, Alarico S, Empadinhas N. "Glucosylglycerate metabolism, bioversatility and mycobacterial survival". Glycobiology 27 (2016): 213-227. http://dx.doi.org/10.1093/glycob/cww132.
    Published • 10.1093/glycob/cww132
  47. Nunes-Costa D, Alarico S, Dalcolmo MP, Correia-Neves M, Empadinhas N. "The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil". Tuberculosis 96 (2016): 107-119. http://dx.doi.org/10.1016/j.tube.2015.09.006.
    Published • 10.1016/j.tube.2015.09.006
  48. Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL. "Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep17144.
    Published • 10.1038/srep17144
  49. Maranha A, Moynihan PJ, Miranda V, Lourenço EC, Nunes-Costa D, Fraga JS, Pereira PJB, Macedo-Ribeiro S, Ventura MR; Clarke AJ, Empadinhas N. "Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13610.
    Published • 10.1038/srep13610
  50. Fraga JS, Maranha A, Mendes V, Pereira PJB, Empadinhas N*, Macedo-Ribeiro S*. "Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway". Scientific Reports 5 (2015): https://doi.org/10.1038/srep08026.
    Published • 10.1038/srep08026
  51. Alarico S, Costa M, Sousa MS, Maranha A, Lourenço EC, Faria TQ, Ventura MR, Empadinhas N. "Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate". Scientific Reports 4 1 (2014): http://dx.doi.org/10.1038/srep06766.
    Published • 10.1038/srep06766
  52. Bento CF, Empadinhas N, Mendes N. "Autophagy in the fight against tuberculosis". DNA and Cell Biology 34 4 (2014): 228-242. https://doi.org/10.1089/dna.2014.2745.
    Published • 10.1089/dna.2014.2745
  53. Nobre A, Alarico S, Maranha A, Mendes V, Empadinhas N. "The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies". Microbiology (United Kingdom) 160 PART 8 (2014): 1547-1570. https://doi.org/10.1099/mic.0.075895-0.
    Published • 10.1099/mic.0.075895-0
  54. Alarico S, Empadinhas N, da Costa MS. "A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1,2)-D-glycerate and alpha-D-glucopyranosyl-(1,2)-D-glycerate". Enzyme and Microbial Technology 52 2 (2013): 77-83. http://dx.doi.org/10.1016/j.enzmictec.2012.10.008.
    Published • 10.1016/j.enzmictec.2012.10.008
  55. Nobre A, Empadinhas N, Nobre MF, Lourenço EC, Maycock C, Ventura MR, Mingote A, da Costa MS. "The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate". Planta 237 3 (2013): 891-901. https://doi.org/10.1007/s00425-012-1808-6.
    Published • 10.1007/s00425-012-1808-6
  56. Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJB, Empadinhas N. "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins". Journal of Bacteriology 194 24 (2012): 7010-7011. DOI: https://doi.org/10.1128/JB.01880-12.
    Published • 10.1128/JB.01880-12
  57. Mendes V, Maranha A, Alarico S, Empadinhas N. "Biosynthesis of mycobacterial methylglucose lipopolysaccharides". Natural Product Reports 29 8 (2012): 834-844. https://doi.org/10.1039/C2NP20014G.
    Published • 10.1039/c2np20014g
  58. Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N. "Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis". Scientific Reports 1 1 (2011): http://dx.doi.org/10.1038/srep00177.
    Published • 10.1038/srep00177
  59. Empadinhas N, Pereira PJB, Albuquerque L, Costa J, Sá-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS. "Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity". Molecular Microbiology 79 1 (2011): 76-93. https://doi.org/10.1111/j.1365-2958.2010.07432.x.
    Published • 10.1111/j.1365-2958.2010.07432.x
  60. Empadinhas N, da Costa MS. "Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea". Environmental Microbiology 13 8 (2011): 2056-2077. https://doi.org/10.1111/j.1462-2920.2010.02390.x.
    Published • 10.1111/j.1462-2920.2010.02390.x
  61. Fernandes C, Mendes V, Costa J, Empadinhas N, Jorge C, Lamosa P, Santos H, da Costa MS. "Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis". Journal of Bacteriology 192 6 (2010): 1624-1633. https://doi.org/10.1128/JB.01424-09.
    Published • 10.1128/JB.01424-09
  62. Mendes V, Maranha A, Lamosa P, da Costa MS, Empadinhas N. "Biochemical characterization of the maltokinase from Mycobacterium bovis BCG". BMC Biochemistry (2010): https://doi.org/10.1186/1471-2091-11-21.
    Published • 10.1186/1471-2091-11-21
  63. Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS. "A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT". Journal of Bacteriology 190 24 (2008): 7939-7946. http://dx.doi.org/10.1128/jb.01055-08.
    Published • 10.1128/jb.01055-08
  64. Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS. "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". FEMS Microbiology Letters 280 2 (2008): 195-202. https://doi.org/10.1111/j.1574-6968.2007.01064.x.
    Published • 10.1111/j.1574-6968.2007.01064.x
  65. Sá-Moura B, Albuquerque L, Empadinhas N, da Costa MS, Pereira PJB, Macedo-Ribeiro S. "Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 8 (2008): 760-763. https://doi.org/10.1107/S1744309108021490.
    Published • 10.1107/S1744309108021490
  66. Empadinhas N, da Costa MS. "To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerate". Systematic and Applied Microbiology 31 3 (2008): 159-168. https://doi.org/10.1016/j.syapm.2008.05.002.
    Published • 10.1016/j.syapm.2008.05.002
  67. Empadinhas N, da Costa MS. "Osmoadaptation mechanisms in prokaryotes: Distribution of compatible solutes". International Microbiology 11 3 (2008): 151-161. https://europepmc.org/article/med/18843593.
    Published • 10.2436/20.1501.01.55
  68. Pereira PJB, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S. "Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: Structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis". PLoS ONE 3 11 (2008): https://doi.org/10.1371/journal.pone.0003748.
    Published • 10.1371/journal.pone.0003748
  69. Alarico S, da Costa MS, Empadinhas N. "Molecular and physiological role of the trehalose-hydrolyzing a-glucosidase from Thermus thermophilus HB27". Journal of Bacteriology 190 7 (2008): 2298-2305. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549086172&partnerID=MN8TOARS.
    Published • 10.1128/JB.01794-07
  70. Fernandes C, Empadinhas N, da Costa MS. "Single-step pathway for synthesis of glucosylglycerate in Persephonella marina". Journal of Bacteriology 189 11 (2007): 4014-4019. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249786874&partnerID=MN8TOARS.
    Published • 10.1128/JB.00075-07
  71. Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, da Costa MS. "Organic solutes in Rubrobacter xylanophilus: The first example of di-myo-inositol-phosphate in a thermophile". Extremophiles 11 5 (2007): 667-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548303944&partnerID=MN8TOARS.
    Published • 10.1007/s00792-007-0084-z
  72. Alarico S, Empadinhas N, Mingote A, Simões C, Santos MS, da Costa MS. "Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1". Extremophiles 11 6 (2007): 833-840. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748948644&partnerID=MN8TOARS.
    Published • 10.1007/s00792-007-0106-x
  73. Costa J, Empadinhas N, da Costa MS. "Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: Characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina". Journal of Bacteriology 189 5 (2007): 1648-1654. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947366922&partnerID=MN8TOARS.
    Published • 10.1128/JB.00841-06
  74. Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura MR, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H. "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS.
    Published • 10.1128/JB.00465-07
  75. Empadinhas N, da Costa MS. "Diversity and biosynthesis of compatible solutes in hyper/thermophiles". International Microbiology 9 3 (2006): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750584278&partnerID=MN8TOARS.
    Published
  76. Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS. "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology 188 3 (2006): 1022-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-31344453995&partnerID=MN8TOARS.
    Published • 10.1128/JB.188.3.1022-1030.2006
  77. Pires AL, Albuquerque L, Tiago I, Nobre MF, Empadinhas N, Veríssimo A, da Costa MS. "Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species". FEMS Microbiology Letters 245 1 (2005): 39-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744405109&partnerID=MN8TOARS.
    Published • 10.1016/j.femsle.2005.02.011
  78. Alarico S, Empadinhas N, Simões C, Silva Z, Henne A, Mingote A, Santos H, da Costa MS. "Distribution of genes for synthesis of trehalose and mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance". Applied and Environmental Microbiology 71 5 (2005): 2460-2466. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382346&partnerID=MN8TOARS.
    Published • 10.1128/AEM.71.5.2460-2466.2005
  79. Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. "Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus". Journal of Biological Chemistry 279 11 (2004): 9892-9898. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M312186200
  80. Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MAS, Santos H, da Costa MS. "A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase". Journal of Bacteriology 186 13 (2004): 4075-4084. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042523198&partnerID=MN8TOARS.
    Published • 10.1128/JB.186.13.4075-4084.2004
  81. Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS. "The bacterium Thermus thermophilus, like hyperthermophilic Archaea, uses a two-step pathway for the synthesis of mannosylglycerate". Applied and Environmental Microbiology 69 6 (2003): 3272-3279. http://dx.doi.org/10.1128/aem.69.6.3272-3279.2003.
    Published • 10.1128/aem.69.6.3272-3279.2003
  82. Santos P, Pinhal I, Rainey FA, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A, da Costa MS. "Gamma-Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media". Applied and Environmental Microbiology 69 11 (2003): 6533-6540. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242573382&partnerID=MN8TOARS.
    Published • 10.1128/AEM.69.11.6533-6540.2003
  83. Alarico S, Rainey FA, Empadinhas N, Schumann P, Nobre MF, da Costa MS. "Rubritepida flocculans gen. nov., sp. nov., a new slightly thermophilic member of the a-1 subclass of the Proteobacteria". Systematic and Applied Microbiology 25 2 (2002): 198-206. http://dx.doi.org/10.1078/0723-2020-00116.
    Published • 10.1078/0723-2020-00116
  84. Albuquerque L, Santos J, Travassos P, Nobre MF, Rainey FA, Wait R, Empadinhas N, Silva MT, da Costa MS. "Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum". Applied and Environmental Microbiology 68 9 (2002): 4266-4273. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036729238&partnerID=MN8TOARS.
    Published • 10.1128/AEM.68.9.4266-4273.2002
  85. Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes". Journal of Biological Chemistry 276 47 (2001): 43580-43588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M108054200
  86. Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H. "Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase". Journal of Biological Chemistry 274 50 (1999): 35407-35414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033544948&partnerID=MN8TOARS.
    Published • 10.1074/jbc.274.50.35407
Magazine article
  1. Sandra M. Cardoso, Nuno Empadinhas. "O papel do eixo microbioma-intestino-cérebro em doenças neurodegenerativas", Cidade Solidária, 2017
  2. Nuno Empadinhas. "Fundação Mizutani, no Japão, apoia investigação inovadora realizada em Portugal", Sociedade Portuguesa de Microbiologia, 2012, https://spmicrobiologia.wordpress.com/2012/08/01/fundacao-mizutani-no-japao-apoia-investigacao-inovadora-realizada-em-portugal/.
Newspaper article
  1. Nuno Empadinhas. "Microbiologia: uma teoria de tudo para a Vida na Terra", Diário de Notícias, 2024, https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/.
  2. Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa", Público, 2021, https://www.publico.pt/2021/10/20/ciencia/noticia/micobacterias-agua-ameaca-silenciosa-1981724.
  3. Nuno Empadinhas. "A Resistência a Antibióticos num Planeta de Micróbios e o Alerta da OMS", Diário de Coimbra, 2014
Thesis / Dissertation
  1. Empadinhas, Nuno. "Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implications". PhD, Universidade de Coimbra, 2005. https://estudogeral.sib.uc.pt/handle/10316/1996.
  2. Empadinhas, Nuno. "A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1996.

Artistic / Performance

Visual artwork
  1. Voyages in Tuberculosis (2019) André Caetano (Art); Nuno Empadinhas & João Ramalho-Santos (Text);. João Ramalho-Santos & Sara Amaral (Coordination); with contributions from Ana Maranha, Ana Teresa Viegas, Daniela Costa, Inês Roxo, João Cardoso, Mafalda Costa, Mariana Silva and Susana Alarico (https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484).
  2. Brain Voyages (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination & te. Ana Cristina Rego, Ana Luísa Carvalho, Ana Rita Álvaro, Carla Lopes, Carlos Duarte, Cláudia Cavadas, Cláudia Pereira, João Peça, Luana Naia, Luís Pereira Almeida, Nuno Empadinhas, Paula Moreira, Paulo Pinheiro, Ramiro Almeida, Ricardo Rodrigues, Sandra Morais Cardoso, Sandra Mota. (https://www.publico.pt/2017/03/24/ciencia/fotogaleria/viagens-no-cerebro-em-bd-371640).
  3. Diabetic Journeys (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination. Alexandrina Mendes, Ana Duarte, Ana R Álvaro, Ana T Viegas, Cláudia Cavadas, Cristina Carvalho, Ermelindo Leal, Eugénia Carvalho, João Alves, John Jones, Ludgero Tavares, Mireia Alemany, Nuno Empadinhas, Paula Moreira, Paulo Oliveira, Pedro Gomes, Renata Tavares, Sandra Amaral, Sara Silva, Sónia Correia, Susana Cardoso (https://www.publico.pt/2017/11/14/ciencia/fotogaleria/viagens-na-diabetes-em).

Intellectual property

Patent
  1. da Costa MS, Empadinhas N. 2009. "Massive production of mycobacterial glucosyl-3-phosphoglycerate synthase and the use of this enzyme as a target for antimycobacterial substances. WO2009028973.".
  2. da Costa MS, Empadinhas N, Albuquerque L, Santos H. 2005. "Identification of a bifunctional gene for mannosylglycerate synthesis and development of a high-scale-production heterologous system based on Sacharomyces cerevisiae. EP1526180A1.".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2026/01/15 Microbiomas invisíveis: ambiente, saúde e doença Ciclo de Conversas com Ciência, 4.ª edição - Microbiomas "invisíveis"
Ciência Viva - Clubes Ciência Viva na Escola https://clubes.cienciaviva.pt/iniciativas/ (Portugal)
2025/11/18 O Microbioma intestinal: um ecossistema invisível https://ordem-dos-biologos.odoo.com/event/o-eixo-microbioma-imunidade-inflamacao-uma-visao-integrada-para-o-ensino-basico-e-secundarios-36/register
Ordem dos Biólogos (Portugal)
2025/09/15 Polymethylated polysaccharides in mycobacteria: Dissecting their roles in stress adaptation and pathogenesis 15th International Joint Meeting GLUPOR 15 & GLYCOTwinning 2025
(Portugal)
2025/09/15 Structural studies of a highly thermostable GpgS reveal a cryptic aromatic binding pocket 15th International Joint Meeting GLUPOR 15 & GLYCOTwinning 2025
(Portugal)
2025/03/21 Microbiologia da Doença de Parkinson XVIII Congresso Científico NEF/AAC
Faculdade de Farmácia da Universidade de Coimbra
2025/01/13 The gut microbiome in Parkinson’s Disease in a declining environment PDBEB Advanced Course "Pathogenic Mechanisms of Neuropsychiatric and Neurodegenerative Disorders"
Centro de Neurociências e Biologia Celular, Universidade de Coimbra (Coimbra, Portugal)
2024/05/22 Da biosfera ao microbioma intestinal: alimentação, imunidade e declínio da saúde global Ciclo Sistema Imunitário e o Microbiota
CECAV - AL4AnimalS - Universidade de Trás-os-Montes e Alto Douro (Portugal)
2024/03/27 A microbiologia da doença de Parkinson: os guardiões da via intestino-cérebro Ciclo "Microbioma Humano”
Academia das Ciências de Lisboa (Portugal)
2024/03/06 Aprender com as guerras entre micróbios: dos antibióticos à doença de Parkinson Semana da Biotecnologia - Núcleo de Biotecnologia
Politécnico de Leiria - Escola Superior de Turismo e Tecnologia do Mar (Portugal)
2024/02/23 Microbioma e cancro Pós-Graduação em Bioquímica e Hematologia
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2024/01/16 Self-recycling and replication of mycobacterial methylmannose polysaccharides for cold adaptation 7th Iberian Carbohydrate Meeting
(Sitges-Barcelona, Spain)
2023/01/17 Methylglucose vs methylmannose polysaccharides: biosynthesis, distribution and proposed roles in adaptation of mycobacteria to heat or cold 14th International Meeting of the Portuguese Carbohydrate Group (GLUPOR 14)
NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal (Caparica, Portugal)
2023/01/04 What do mycobacteria and cyanobacteria have in common when it comes to public health? DCV Talks
Life Sciences Department, UC (Coimbra, Portugal)
2022/07/14 The role of the gut microbiome in neurodegenerative diseases Portugal & Brasil Joint Meeting @CNC
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2022/06/13 Mycobacterial biogenesis of polymethylated polysaccharides FASEB - The Microbial Glycobiology Conference
FASEB Science Research Conference (SRC) (Lisboa, Portugal)
2022/05/11 Microbiome weapons and shields in metabolic, neurodegenerative and infectious diseases Programa de Doutoramento em Ciências Farmacêuticas
Faculdade de Farmácia da Universidade de Coimbra (Portugal)
2022/04/07 The gut microbiome in PD: active player or bystander? Metabolic and Inflammatory Drivers in Age-Related Neurodegenerative Diseases
PDBEB Advanced Course (Coimbra, Portugal)
2022/03/27 Microbiology of Parkinson's Disease XIII Symposium on Bioengineering "Turning Science into Miracles"
Faculdade de Engenharia da Universidade do Porto + ICBAS (Porto, Portugal)
2022/03/26 Ecologia e Epidemiologia das Micobactérias Não Tuberculosas XXIX Congresso de Pneumologia do Norte
Serviços de Pneumologia do Centro Hospitalar Universitário de São João e do Centro Hospitalar de Vila Nova de Gaia/Espinho (Centro de Congressos Sheraton Porto, Portugal)
2021/11/16 Novos caminhos de investigação em Tuberculose, na língua que nos une A Bienal STEM+L 2021 - Aprendizagem da Ciência, Tecnologias, Engenharia e Matemática, na Língua que nos une
OSUWELA | UNESCO | UPM (Maputo, Mozambique)
2021/07/14 Antimicrobial resistance in rare mycobacteria isolated from a tertiary hospital environment 4th International Caparica Congress In Antibiotic Resistance
NOVA University of Lisbon (Caparica, Portugal)
2021/04/27 Pathogen-microbiome-host interactions in health and disease Programa Doutoral em Ciências Farmacêuticas 2020-21
Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2021/03/16 The deadliest pathogens of all time Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2021/03/15 Microbial diversity in the 4-domain Tree of Life: an infective overview Fighting Infection course, Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2020/09/19 Mycobacteria: Complete biosynthesis of unique polysaccharides and the art of furtiveness 2nd CIBB Innovative Therapies Retreat 2020
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Universidade de Coimbra (Coimbra, Portugal)
2020/01/31 Distribution of mycobacterial polymethylated polysaccharides and their possible role in stress adaptation 2º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2019/12/20 Parkinsons disease: a symptom of latent infection? CIBB Meeting 2019
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/12/19 A novel mycobacterial pathway for biogenesis of rare lipid transfer polysaccharides implicated in cell envelope assembly CIBB Meeting 2019
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/10/01 Polysaccharide biosynthesis vs recycling and replication in mycobacteria 7th Symposium on the Alpha-Amylase Family
Slovak Academy of Sciences (Smolenice, Slovakia)
2019/09/20 Unveiling mycobacterial methylmannose polysaccharide biosynthesis: a unique 1-O-methyltransferase specific for 3-O-methylated mannosides MycoPORTO
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (Porto, Portugal)
2019/09/15 Cerveja: uma fonte de potenciais benefícios para a saúde do cérebro via microbioma intestinal Brew - Mesa Redonda: Saúde e Cerveja
Exploratório Ciência Viva (Coimbra, Portugal)
2019/06/07 A brave new world of gut microbiome-host interactions shaping health and disease 3as Jornadas de Cirurgia Colorectal (https://www.spcir.com/wp-content/uploads/2019/04/JORNADAS-DE-CIRURGIA-CR-ENTRE-LIS-E-TEJO-PROGRAMA-PRELIMINAR.pdf)
Centro Hospitalar de Leiria (Monte Real, Portugal)
2019/06/04 O papel do eixo intestino-cérebro na Doença de Parkinson IV Conference SANTA CASA Neurociências Um Olhar no Futuro" Longevidade e Doenças Neurodegenerativas
Santa Casa da Misericórdia de Lisboa, Pavilhão do Conhecimento, Centro Ciência Viva (Lisboa, Portugal)
2019/05/06 Doenças causadas por micobactérias: A tuberculose e outras muito sérias Centenário da Escola Secundária Gabriel Pereira 1919-2019
Escola Secundária Gabriel Pereira (Évora, Portugal)
2018/09/21 Molecular Mycobacteriology and the Microbiome in Communicable Diseases 9th EDCTP Forum: Clinical research and sustainable development in sub-Saharan Africa
European & Developing Countries Clinical Trials Partnership (EDCTP) Coimbra Hospital and University Center (CHUC) and University of Coimbra (UC) Health Science Campus (Coimbra, Portugal)
2018/06/18 Secrets of mycobacterial biology: de novo polysaccharide synthesis vs recycling & replication 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2018/05/17 The hidden microbiome in Parkinson's Disease 9th Annual World Congress NeuroTalk
BIT Group Global (Bangkok, Thailand)
2018/04/19 Pathways to stem the tide of TB drug resistance in the midst of a TB-Diabetes storm World Health Summit Regional Meeting 2018
University of Coimbra and Coimbra Hospital and Universitary Centre (CHUC) (Coimbra, Portugal)
2018/03/03 Viver com os micróbios: resistência a antibióticos e o microbioma humano MeetLab - II Encontro de Laboratório
Departamento Ciências da Vida, Universidade de Coimbra (Coimbra, Portugal)
2017/12/06 The gut microbiome in health and disease: key players and mechanisms PhD Programme in Health Sciences, Molecular Mechanisms of Disease
Faculdade de Medicina, Universidade de Coimbra (Coimbra, Portugal)
2017/04/07 Mycobacterial pathways from simple glycosides to fatty-acid shuttling polysaccharides Symposium Mycobacterium: Molecular Microbiology
National Center for Biotechnology, Universidad Autónoma de Madrid (Madrid, Spain)
2016/12/20 TB and not TB in the 21st century: a quest for new target-tailored precision antibiotics 1st Meeting on Biomedical Research @ UC
Universidade de Coimbra (Coimbra, Portugal)
2016/10/14 Como erguer uma parede impermeável: novas pistas no genoma de Mycobacterium tuberculosis VII Congresso Nacional da Fundação Portuguesa do Pulmão
Fundação Portuguesa do Pulmão (Lisboa, Portugal)
2016/07/06 Decrypting a vital pathway of Mycobacterium tuberculosis: towards new intervention strategies Ciência 2016 - Encontro com a Ciência e Tecnologia em Portugal
Fundação para a Ciência e a Tecnologia, Centro de Congressos de Lisboa (Lisboa, Portugal)
2016/06/23 Pathway for synthesis of methylglucose lipopolysaccharide in Mycobacterium tuberculosis The 2016 TB Summit
The Royal Society of Chemistry (London, United Kingdom)
2015/06/05 Exposing cryptic mycobacterial pathways: leaving no enzyme behind Friday Seminars at IBMC
Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto (Porto, Portugal)
2015/05/07 O microbioma humano e a resistência a antibióticos num planeta de micróbios Jornadas de Química e Bioquímica, Universidade da Beira Interior
Universidade da Beira Interior (Covilhã, Portugal)
2015/04/28 O combate à tuberculose: novos intermediários metabólicos essenciais Brokerage Event INESPO II
Divisão de Inovação e Transferências do Saber (DITS) (Coimbra, Portugal)
2015/01/27 Mycobacterial resistance to old antibiotics and potential biosynthetic pathways for new ones IC2AR, 1st International Caparica Conference in Antibiotic Resistance
Universidade NOVA de Lisboa (Caparica, Portugal)
2015/01/26 Exposing new mycobacterial drug targets from unique metabolic pathways IC2AR, 1st International Caparica Conference in Antibiotic Resistance
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Caparica, Portugal)
2014/12/15 When microbes get on your nerves Annual Meeting of the Center for Neuroscience and Cell Biology
Universidade de Coimbra (Coimbra, Portugal)
2013/02/08 Reconstructing mycobacterial pathways from missing enzyme links: playing hide and seek Winter CNC.IBILI Seminars
Center for Neuroscience and Cell Biology (CNC) (Coimbra, Portugal)
2013/01/26 Civilização: o paraíso das micobactérias Seminars at Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (Mamarrosa, Portugal)
2012/07/25 Missing links in mycobacterial MGLP biosynthesis: the early players Seminars at the Department of Biochemistry, University of Cambridge
Department of Biochemistry, Sanger Building, University of Cambridge (Cambridge, United Kingdom)
2010/09/24 O planeta das micobactérias Palestras no Museu da Ciência
Museu da Ciência da Universidade de Coimbra (Coimbra, Portugal)
2010/03/24 Biossíntese de polissacáridos raros em Mycobacterium (Dia Mundial da Tuberculose) Feira de Ciência e Tecnologia
Faculdade de Ciências e Tecnologia, Universidade de Coimbra (Coimbra, Portugal)
2008/12/16 Biosynthesis of MGLP in M. tuberculosis. Identification of genes and characterization of enzymes 6th Annual Meeting of the Center for Neuroscience and Cell Biology
Fundação Bissaya-Barreto (Coimbra, Portugal)
2008/12/12 Compatible solutes in thermophiles and hyperthermophiles Stress Responses in the Microbial World
Belgian Society for Microbiology (Brussels, Belgium)
2008/03/24 A caminho de um novo antibiótico (Dia Mundial da Tuberculose) Semana da Tuberculose
Associação Nacional de Tuberculose e Doenças Respiratórias (Lisboa, Portugal)
2007/09/03 Biosynthesis and accumulation of compatible solutes in hyper/thermophiles Halophiles 2007 - 8th International Congress Exploring Life at High Salinity
University of Essex (Colchester, United Kingdom)
2007/06/01 The accumulation and biosynthesis of compatible solutes in thermophiles and hyperthermophiles VII Congrés de la Société Française de Microbiologie
Société Française de Microbiologie (Nantes, France)
2006/09/20 Rubrobacter xylanophilus MpgS. Evolution of MG and GG biosynthesis in prokaryotes "Extremophiles 2006", International Conference on Extremophiles
International Society for Extremophiles (Brest, France)
2006/05/22 The mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus "HotSolutes" Final Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2004/10/15 Biosynthesis of glucosylglycerate: a "coldsolute" from prokaryotes 3rd "HotSolutes" Meeting
Universita Degli Studi di Ferrara (Ferrara, Italy)
2004/09/25 Nature's shields to environmental stress: biosynthesis of compatible solutes in extremophiles 2nd Annual Meeting of the Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology (Luso, Portugal)
2004/02/27 Optimizing mannosylglycerate production by Saccharomyces cerevisiae 1st "HotSolutes" Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2003/11/21 Production of mannosylglycerate by Saccharomyces cerevisiae 6th "Hypersolutes" Meeting
Technische Universtität Hamburg (Hamburgo, Germany)
2003/03/08 Production of mannosylglycerate in mesophilic organisms 5th "Hypersolutes" Meeting
Instituto de Tecnologia Química e Biológica (Alcochete, Portugal)
2002/03/01 Synthesis of mannosylglycerate at room temperature: properties of a mesophilic mannosylglycerate synthase 3rd "Hypersolutes" Meeting
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2001/10/23 Genes for the synthesis of mannosylglycerate at high and room temperature: characterization of key-enzymes 2nd "Hypersolues" Meeting
Universitaet Konstanz (Konstanz, Germany)
2001/07/02 Biosynthesis of mannosylglycerate in the hyperthermophile Pyrococcus horikoshii: characterization of key-enzymes 27th FEBS Meeting
Federation of European Biochemical Societies (Lisboa, Portugal)
2001/02/10 Mannosylglycerate biosynthesis in Pyrococcus horikoshii: characterization of key-enzymes 1st "Hypersolutes" Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Oeiras, Portugal)

Supervision

Thesis Title
Role		 Degree Subject (Type)
Institution / Organization
2024 - Current Microbial synthesis of neuroactive metabolites and bacteriotherapeutic strategies in PD
Supervisor of Sara Miguel Gonçalves
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024 - Current Bacterial extracellular vesicles and intestinal immune regulation in autism spectrum disorder
Co-supervisor of Inês Melo Marques
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023 - Current Novos diterpenóides semi-sintéticos para o tratamento de infeções resistentes
Co-supervisor of Olha Antoniuk
 Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2025 - 2026 Identification of bacteria from chronic disease patients and their households: focus on antimicrobial susceptibility
Supervisor of Beatriz Nunes Maria
 Biomedical Sciences (Master)
Université de Genève, Switzerland
2024 - 2025 In search of novel antimicrobial agents against DFU harnessing the power of bacterial competition
Co-supervisor of Luísa Baptista
 Microbiologia e Biotecnologia Microbiana (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021 - 2025 Deciphering the impact of microbiome-immune interplay in Schizophrenia
Co-supervisor of Ana Raquel Santos
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2020 - 2025 Exploring domestic water systems and gut microbiomes in mycobacterial diseases: Uncovering bacterial diversity and searching for novel antimycobacterials
Supervisor of Inês Cravo Roxo
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2023 - 2024 Activation of innate immunity in macrophages by nontuberculous mycobacteria
Co-supervisor of Sara Tatiana Freitas
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019 - 2024 The impact of bacterial infection in gut first Parkinson’s Disease: the influence of innate immunity activation in alpha-synuclein expression and mitochondrial dysfunction
Co-supervisor of João Duarte Magalhães
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2023 Conflicting interactions between methylobacteria and mycobacteria from drinking water
Co-supervisor of Ana Afonso Dias
 Microbiologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022 - 2023 Profiling mycobacteria isolated from the houses of patients with NTM disease
Co-supervisor of Maria Carolina Fernandes
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2022 Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology
Supervisor of Daniela Cristina Nunes Costa
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2020 - 2021 Biosynthesis of serotonin in bacteria: an exploratory study
Supervisor of Sara Miguel Gonçalves
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2021 Identification of NTM proteins involved in cell aggregation and biofilm formation
Co-supervisor of Ana Rita Fonseca
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Esterilização supercrítica de aerogéis compostos por polímeros naturais para aplicações biomédicas
Co-supervisor of Cristiana Amaral Bento
 Engenharia Química (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2019 Mycobacterial methylmannose polysaccharides’ biosynthesis
Supervisor of Maria Mafalda Santos Costa
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 - 2018 Antimicrobial susceptibility and competition of diabetic skin microbiota
Co-supervisor of Antonella DiCaro
 Erasmus+ Programme (Specialization course)
Università degli Studi del Sannio, Italy
2016 - 2018 Deciphering microbiome signatures in chronic diseases
Supervisor of Ana Branco Maranha Tiago
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2018 Functional and structural studies of potential targets of mycobacterial pathways
Co-supervisor of Jorge Ripoll Rozada
Pós-Doutoramento
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015 - 2018 Defining the missing links in mycobacterial methylglucose lipopolysaccharide biosynthesis
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2018 Biochemical and structural characterization of mycobacterial drug targets
Co-supervisor of Tatiana Barros Reis Cereija
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 Isolation of ESKAPE pathogens from diabetic wounds
Co-supervisor of Pau Porras Socias
 Biotechnology (Erasmus+ Programme) (Master)
Universitat de Barcelona Facultat de Biologia, Spain
2015 - 2016 Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stress
Supervisor of Cristina Isabel da Silva Martins
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2016 Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratório
Supervisor of Ana Catarina Silva Monteiro
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2016 Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis
Supervisor of Ana Branco Maranha Tiago
 Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015 Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria
Supervisor of Daniela Cristina Nunes Costa
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2015 Molecular and physiological characterization of two crucial enzymes from M. tuberculosis
Supervisor of Vitor Gonçalo Costa Mendes
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2015 The early steps in methylglucose lipopolysaccharide biosynthesis in mycobacteria
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014 Perfis de resistência a antimicrobianos de estirpes de Mycobacterium isoladas de ambiente hospitalar
Supervisor of Diogo José Pereira Reis
 Biotecnologia dos Recursos Marinhos (Master)
Instituto Politécnico de Leiria, Portugal
2012 - 2013 Biosynthesis of rare methylglucose lipopolysaccharides in rapidly-growing mycobacteria : characterization of a key hydrolase
Supervisor of Maria Mafalda Santos Costa
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012 Análise funcional de maltocinases e trealose sintases/maltocinases bifuncionais
Supervisor of Andreia Filipa Nisa Mendes Lamaroso
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2012 Deciphering the regulatory mechanisms controlling compatible solutes biosynthesis in Thermus thermophilus osmo- and thermoadaptation
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2011 New insights into the biosynthesis of the mycobacterial methylglucose lipopolysaccharide
Supervisor of Vitor Gonçalo Silva e Costa Mendes
 Bioquímica / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2010 A multifactorial approach to the biological role of the mycobacterial maltokinase
Supervisor of Ana Branco Maranha Tiago
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2009 Relevance of MG and trehalose in the osmoadaptation of Thermus thermophilus
Co-supervisor of Susana Isabel Elias Alarico
 Biologia / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2009 Osmotic and thermal adaptation in ancient thermophilic bacteria : biosynthesis of glucosyglycerate and mannosylglucosylglycerate
Co-supervisor of Chantal Ana Vicência Fernandes
 Bioquímica / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)		 Institution / Organization
2026/03/04 - 2027/03/08 Microbes in Health, Disease, and Innovation (4-8 March 2027), PhD Programme in Experimental Biology and Biomedicine (2026 - 2027) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2025/09/15 - 2025/09/17 International Joint Meeting GLUPOR 15 & GLYCOTwinning 2025 (https://glupor15.events.chemistry.pt/) (2025/09/15 - 2025/09/17)
Meeting (President of the Organising Committee)
 Sociedade Portuguesa de Química, Portugal
2025/06/22 - 2025/06/25 The 45th Annual Congress of the European Society of Mycobacteriology (2025/06/22 - 2025/06/25)
Congress (Member of the Organising Committee)
 European Society of Mycobacteriology, Germany
2024/05/15 - 2024/05/16 BEB Day 2024 - (Not) Knowing What Comes Next. Coordinators: Nuno Empadinhas & John Jones; Organizing Committee: Alejandra Nunez, Carolina Mendes, Luísa Matos, Sofia Figueira, Beatriz Ribeiro, Emanuel Tahiri, Inês Moniz, João Gabriel Silva, Laura Carvalho, Mariana Diniz, Sara Martins, Simão Santos, Solange Martins. https://cnc.uc.pt/en/dia-do-beb-2024 (2024/05/15 - 2024/05/16)
Symposium (Other)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/01/15 - 2024/01/17 7th Iberian Carbohydrate Meeting (https://www.iberiancarbohydrate2024.com/index.php/organizers) (2024/01/15 - 2024/01/17)
Conference (Member of the Organising Committee)
 Carbohydrate Group of the Real Sociedad Española de Química (RSEQ), Spain

Grupo dos Glúcidos da Sociedade Portuguesa de Química, Portugal
2023/02/07 - 2023/02/08 BEB Day 2023 - Science Challenges: This Fight of Ours. Coordinator: Nuno Empadinhas; Organizing Committee: Ana Vasconcelos, Débora Mena, Frederico Pena, João Novo, Maria Inês Cristo, Rafaela Ferrão. https://www.uc.pt/iii/agenda-ensino-iiiuc/beb-day-2023/ (2023/02/07 - 2023/02/08)
Symposium (Other)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/01/18 - 2022/01/19 BEB Day 2022 - The Overview Effect. Coordinator: Nuno Empadinhas. Organizing Committee: Carlos Barreto, Inês Caramelo, Inês Roxo, Luís Grilo, Maria Alfaiate, Mariana Magalhães, Raquel Santos, Rita Santos. https://www.uc.pt/en/iii/bebday/bebday2022/ (2022/01/18 - 2022/01/19)
Symposium (Member of the Scientific Committee)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2018 - 2022 Fighting Infection Course, PhD Programme in Experimental Biology and Biomedicine (2018 - 2022)
Other (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2021/09/17 - 2021/09/17 3rd CIBB Innovative Therapies Retreat 2021. Organizing Committee: Nuno Empadinhas, Irina Moreira, Hugo Fernandes. (2021/09/17 - 2021/09/17)
Meeting (Co-organiser)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/05 - 2019/04/05 Mycobacterial Glycoimmunology Joint Meeting 2019. Organizers/Participants: Nuno Empadinhas, Margarida Correia Neves, Gunilla Kallenius, Chritopher Sundling, Susana Alarico, Ana Maranha, Mafalda Costa, Daniela Costa. (2019/04/05 - 2019/04/05)
Meeting (Co-organiser)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/12/07 - 2018/12/07 1st Microbiome-Gut-Brain Axis Joint Meeting. Organizers: Nuno Empadinhas & Sandra M. Cardoso. (2018 - 2018)
Meeting (Co-organiser)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/06/18 - 2018/06/18 1º Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal. Chair: Nuno Empadinhas. Scientific Committee: Raquel Duarte, Margarida Correia-Neves, Miguel Viveiros. Organizing Committee: Mafalda Costa, Ana Maranha, Susana Alarico, Daniela Costa, John Marugg, Olena Radomska. (2018/06/18 - 2018/06/18)
Symposium (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2012 Medical Microbiology Course, PhD Programme in Experimental Biology ad Biomedicine (2012 - 2012)
Other (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006 - 2011 Microbiology Course, PhD Programme in Experimental Biology and Biomedicine (2006 - 2011)
Other (Co-organiser)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2005 - 2005 Microbiology of Extreme Environments Course, PhD Programme in Experimental Biology ad Biomedicine (2005 - 2005)
Other (Co-organiser)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Jury of academic degree

Topic
Role		 Candidate name (Type of degree)
Institution / Organization
2026/02/27 Exploring domestic water systems and gut microbiomes in mycobacterial diseases: Uncovering bacterial diversity and searching for novel antimycobacterials
Supervisor
 Inês Cravo Roxo (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2025/07/16 Development of a colorimetric bacterial detection device for urinary catheters
(Thesis) Arguer
 Marta Patrícia Carvalho dos Santos (PhD)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2024/12/18 Salmonella-host cell interactions: Unraveling key host determinants of infection of epithelial cells
(Thesis) Arguer
 Jane Santos Dias (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/03/25 Impact of Nutrition on Gut Microbiota: Implications to Parkinson's Disease
(Thesis) Main arguer
 Joana Rocha Sobral (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2024/03/18 Deciphering unexploited features of drug-repurposing beta-lactams against tuberculosis: from genomic patterns of Mycobacterium tuberculosis susceptibility to synergistic combinations
(Thesis) Main arguer
 Francisco Olivença Miguel (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/01/30 Staphylococcus aureus intracellular lifestyle: phenotypic profiles and underlying molecular determinants
(Thesis) Arguer
 Inês Rodrigues Lopes (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/27 The role of micronutrients in unconventional T cells: How RA-signalling controls iNKT cells development
(Thesis) Main arguer
 Diogo Vieira da Silva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/03/21 Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology
Supervisor
 Daniela Cristina Nunes Costa (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/16 Enterobacteriaceae as mediators for carbapenems resistance transfer between environmental and human settings
(Thesis) Arguer
 Pedro Filipe de Sá Teixeira (PhD)
Universidade de Aveiro, Portugal
2021/11/30 Risk factors associated with multidrug-resistant tuberculosis transmission in Portugal
(Thesis) Main arguer
 Olena Radomska (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/12/16 Changes in the gut-brain axis during aging
(Thesis) Main arguer
 João Tomás Barros (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/07 Towards a better understanding of host cell requirements for Salmonella cytosolic replication
(Thesis) Main arguer
 Susana Santos Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/07/22 Mycobacterial methylmannose polysaccharides’ biosynthesis
Supervisor
 Maria Mafalda Santos Costa (PhD)
Universidade de Coimbra, Portugal
2018/09/28 Novos materiais para a oxigenação melhorada de culturas de células e de scaffolds para engenharia de tecidos
(Thesis) Main arguer
 Mariana Hugo Silva (Master)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2017/06/16 O papel do mitoribossoma na função mitocondrial: Implicações para a Doença de Parkinson
(Thesis) Main arguer
 Ana Mafalda Gonçalves (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06/09 Unraveling the protection mechanisms in the radiation resistant bacterium Deinococcus radiodurans
(Thesis) Main arguer
 Sandra Isabel Santos (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09/24 Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em Streptacidiplilus jiangxiensis sob diferentes condições de stress
Supervisor
 Cristina Martins (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/23 Colesterol Oxidase, Hormonas Sexuais e Suscetibilidade à Tuberculose
Supervisor
 Ana Monteiro (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/07/25 A genomic exploration of transmissibility in Mycobacterium tuberculosis
(Thesis) Main arguer
 Hanna Nebenzahl Guimarães (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016/01/13 Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis
Supervisor
 Ana Branco Maranha Tiago (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/07/17 Molecular characterization of Klebsiella pneumoniae beta-lactamases from patients with renal transplants admitted to the Coimbra University Hospital
(Thesis) Arguer
 Delfino Vubil (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/17 Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria
Supervisor
 Daniela Cristina Nunes Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/13 Characterizing Iron Transporters in Plasmodium species
(Thesis) Main arguer
 Aparajita Lahree (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/11/26 New Retroviral-Like Membrane-Associated Aspartic Proteases from Rickettsiae: Biochemical Characterization and Specificity Profiling
(Thesis) Arguer
 Rui Gonçalo Cruz (PhD)
Universidade de Coimbra, Portugal
2014/11/07 Fe/S Cluster Biogenesis Regulation by the Janus-faced Regulator, IscR: An Unforeseen Mechanism of DNA Recognition and Discrimination
(Thesis) Arguer
 Joana Abreu Santos (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/10/29 Perfis de resistência a agentes antimicrobianos de 5 estirpes do género Mycobacterium isoladas de ambiente hospitalar
Supervisor
 Diogo Reis (Master)
Instituto Politécnico de Leiria, Portugal
2013/10/31 Diversity of arsenite transporter genes in microbial populations of the abandoned uranium mine in Urgeiriça
(Thesis) Main arguer
 Rui Marques Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09/20 Screening of Saccharomyces cerevisiae strains for recombinant protein expression
(Thesis) Main arguer
 Paulo Espírito Santo (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07/12 Biosynthesis of methylglucose lipopolysaccharides in rapidly growing mycobacteria: characterization of a key hydrolase
Supervisor
 Mafalda Santos Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/07 Analysis of the antimicrobial content of amphibian skin secretions and structural and functional characterization of a novel member of the temporin family (temporin-SHe)
(Thesis) Main arguer
 Sónia Costa André (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/06 Análise functional de maltocinases e trealose sintases/maltocinases bifuncionais
Supervisor
 Andreia Mendes Lamaroso (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/06/04 The Adaptive Response of Mycobacterium avium to Anoxia and Nitric Oxide
(Thesis) Main arguer
 John Edward Pearl (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/05/11 Structure-function Relationships in a Glycosyltransferase, a Phosphatase and an Oxidoreductase
(Thesis) Arguer
 Susana Pires Gonçalves (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/12/09 New Insights into the Biosynthesis of the Mycobacterial Methylglucose Lipopolysaccharide
Supervisor
 Vitor Gonçalo Silva Costa Mendes (PhD)
Universidade de Coimbra, Portugal
2011/09/19 Estratificação vertical das comunidades microbianas da zona mesopelágica, no Atlântico Norte, determinada por pirosequenciação do 16S DNAr
(Thesis) Main arguer
 Luísa Silva Lopes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07/19 Characterization of bacterial strains resistant to uranium for use in bioremediation
(Thesis) Main arguer
 Tânia Miranda Sousa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/04/01 Formation and analysis of metal-induced phosphate rich extracellular nano-particulate in the Cr(VI) resistant strain Ochrobactrum tritici 5bv11
(Thesis) Main arguer
 Pedro Miguel Abreu (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/10 Evolução molecular dos genes pilD e lspE de Legionella pneumophila
(Thesis) Main arguer
 Ana Filipa d’Avó (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/09 A multifactorial approach to the biological role of the mycobacterial maltokinase
Supervisor
 Ana Branco Maranha Tiago (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009/07/24 Osmotic and Thermal adaptation in ancient thermophilic bacteria. Glucosylglycerate and mannosylglucosylglycerate
Supervisor
 Chantal Vicência Fernandes (PhD)
Universidade de Coimbra, Portugal
2009/03/30 Relevance of Mannosylglycerate and Trehalose Accumulation in the Osmoadaptation of Thermus thermophilus
Supervisor
 Susana Isabel Elias Alarico (PhD)
Universidade de Coimbra, Portugal
2008/09/30 Role of Hsp60 and its peptide aa437-460 in experimental Sjogren’s syndrome
(Thesis) Arguer
 Ana Carina Madureira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2026 - Current International Journal of Systematic and Evolutionary Microbiology (1466-5026) Microbiology Society.
2025 - Current iScience (2589-0042) Cell Press
2025 - Current The Lancet Neurology Elsevier Ltd
2024 - Current ACS Infectious Diseases (2373-8227) ACS Publications
2024 - Current Gut Microbes (1949-0984) Taylor & Francis
2024 - Current Ecotoxicology and Environmental Safety (0147-6513) Elsevier
2021 - Current Neurotoxicity Research (1029-8428) Springer
2021 - Current Pulmonology (2531-0437) Elsevier
2020 - Current European Journal of Clinical Investigation (1365-2362) Wiley (Blackwell Publishing)
2020 - Current Microorganisms (2076-2607) MDPI AG
2020 - Current Neuropsychiatric Disease and Treatment (1176-6328) Dove Medical Press
2017 - Current Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine (1179-5484) "Libertas Academica, Ltd."
2016 - Current Archaea (1472-3654) Hindawi Limited
2015 - Current PLoS ONE (1932-6203) Public Library of Science
2015 - Current Scientific Reports (2045-2322) Nature
2014 - Current Biochimica et Biophysica Acta - General Subjects (0304-4165) Elsevier
2014 - Current Frontiers in Molecular Biosciences (2296-889X) Frontiers Media SA
2014 - Current Microbial Drug Resistance (1931-8448) Mary Ann Liebert
2014 - Current World Journal of Microbiology and Biotechnology (1573-0972) Springer-Verlag
2013 - Current Tuberculosis (1472-9792) Elsevier
2012 - Current Folia Microbiologica (1874-9356) Springer-Verlag
2011 - Current Applied Microbiology and Biotechnology (1432-0614) Springer-Verlag
2010 - Current BMC Genomics (1471-2164) Springer (Biomed Central Ltd.)
2010 - Current Enzyme and Microbial Technology (0141-0229) Elsevier
2010 - Current Marine Drugs (1660-3397) MDPI AG
2010 - Current Research in Microbiology (0923-2508) Elsevier
2008 - Current Extremophiles (1433-4909) Springer-Verlag
2008 - Current Journal of Bacteriology (1098-5530) American Society for Microbiology

Association member

Society Organization name Role
2023 - Current SPQ - Sociedade Portuguesa de Química
2018 - Current ASM – American Society for Microbiology
2014 - Current NTM-NET
2014 - Current TBnet
2013 - Current ESM - European Society of Mycobacteriology
2006 - 2016 SPM - Sociedade Portuguesa de Microbiologia

Committee member

Activity description
Role		 Institution / Organization
2024 - Current CNC Advanced Studies Office
Coordinator
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024 - Current CiBB Advanced Studies and Career Development Office
Coordinator
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2021 - Current Associate Editor "Biologia" (Cellular and Molecular Biology) (1336-9563)
Member
 Springer Nature Switzerland AG, Switzerland
2020 - Current Associate Editor of "BMC Microbiology" (Microbial Biochemistry, Physiology and Metabolism)
Member
 BioMed Central Ltd, United Kingdom
2020 - Current Editorial Board of "Antibiotics" (Antibiotic Biosynthesis' Section) (2079-6382)
Member
 Multidisciplinary Digital Publishing Institute AG, Switzerland
2025 - 2025 Local Advisory Board of CoARA-funded UC TREASURE project
Advisor / Consultant
 Universidade de Coimbra, Portugal
2021 - 2024 CNC Advanced Studies Office
Member
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2020 Guest Associate Editor of "Frontiers in Immunology" (Nutritional Immunology) (1664-3224)
Member
 Frontiers Media SA, Switzerland
2016 - 2019 Coordinator CNC.IBILI Seminars Program - Center for Neuroscience and Cell Biology
Coordinator
 CNC.IBILI, Portugal
2015 - 2018 Editorial Board of "Scientific Reports" (2045-2322)
Member
 Springer Nature Limited, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Micobactérias Não Tuberculosas: Do diagnóstico ao tratamento (Invited lecturer) Micobactérias Não Tuberculosas (Post-Bachelor's Specialization) Universidade do Porto Instituto de Saúde Pública, Portugal
2016 - Current Biology of Ageing (Invited lecturer) Engenharia Biomédica (Master's Degree) Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - Current Aging (Invited lecturer) Biologia Celular e Molecular (Master's Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2026/01/19 - 2026/01/23 Unravelling Brain Disorders: Molecular and Cellular Mechanisms from Development to Degeneration (Invited lecturer) Biologia Experimental e Biomedicina (Doctorate) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2025/12/15 - 2025/12/15 Metabolic Diversity (Invited lecturer) Microbiologia e Biotecnologia Microbiana (Master's Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2025/01/13 - 2025/01/17 Mechanisms in Neuropsychiatric and Neurodegenerative Disorders (Invited lecturer) Biologia Experimental e Biomedicina (Doctorate) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/02/17 - 2023/03/10 Bacteriologia Clínica (Invited lecturer) Bacteriologia Clínica (Postgraduate Program) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2021 - 2023 Tuberculose (Invited lecturer) Pós-Graduação (Post-Bachelor's Specialization) Universidade do Porto Instituto de Saúde Pública, Portugal
2021 - 2022 Development in Pharmaceutical Sciences II (Invited lecturer) Ciências Farmacêuticas (Doctorate) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Química Farmacêutica II (Invited lecturer) Ciências Farmacêuticas (Integrated Master's Degree) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Tecnologia de Produção de Vacinas (Invited lecturer) Ciências Farmacêuticas (Integrated Master's Degree) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Biologia Translacional e Biomedicina (Invited lecturer) Biologia (Licenciate Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Molecular Mechanisms of Disease (Invited lecturer) Ciências da Saúde (Doctorate) Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2015 Microbiologia e Microbioma Humano (Coordinator) Microbiologia e Microbioma Humano (High School) Instituto de Educação e Cidadania (IEC), Portugal
2012 - 2012 Microbiologia e Parasitologia (Invited lecturer) Saúde Pública (Master's Degree) Universidade de Coimbra Faculdade de Medicina, Portugal
2008 - 2011 Microbiologia Molecular Bioquímica (Master's Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2011 Microbiologia Bioquímica (Licenciate Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2011 Microbiologia Laboratorial Bioquímica (Licenciate Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2007 Microbiologia (Invited lecturer) Bioquímica (Licenciate Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2003 Evolução e Biodiversidade (Invited lecturer) Biologia (Licenciate Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Evaluation committee

Activity description
Role		 Institution / Organization Funding entity
2023 - Current ANR Grants, Cellular Biology, Developmental Biology and Evolution
Evaluator
 Agence nationale de la recherche, France Agence nationale de la recherche
2024 - 2024 ERA-NET NEURON , ”Transnational Research Projects on Bidirectional Brain-Body Interactions”
Evaluator
 Fundación Española para la Ciencia y la Tecnología, Spain ERA-Net Cofund scheme
2019 - 2023 FCT Final Grant Reports, Panel Experimental Biology and Biochemistry
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2021 - 2021 Innovate Competition, iMed Conference® 13.0 - Lisbon 2021, Jury A
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal AstraZeneca Foundation
2019 - 2020 REWIRE - Reinforcing Women in Research (https://rewire.univie.ac.at/)
Evaluator
 University of Vienna, Austria, Austria COFUND Programme, Marie Sklodowska Curie Actions COFUND Project, European Commission
2015 - 2015 ANR Grants, Panel Immunology and Infection
Evaluator
 Agence nationale de la recherche, France Agence nationale de la recherche
2014 - 2014 Health and Medical Research Fund, Final Grant Reports
Evaluator
 Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region, Hong Kong SAR China Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/03/27 Ciclo de conferências "Microbioma Humano", Academia das Ciências de Lisboa https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/ Diário de Notícias
2020/06/01 Editor's Choice May 2020: Understanding a Mycobacterial Thermophile https://microbiologysociety.org/blog/microbiology-editor-s-choice-understanding-a-mycobacterial-thermophile.html Microbiology Society UK
2019/03/24 Viagens na Tuberculose - Banda desenhada comemorativa do Dia Mundial da Luta Contra a Tuberculose https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484 Público

Interview (tv / radio show)

Program Topic
2022/03/18 - 2022/03/18 Rádio TSF Noticiário Thiomargarita magnífica: descoberta uma bactéria colossal
2021/10/13 - 2021/10/13 A Saúde no Saber Microbiologia e Doenças Infeciosas
2019/03/03 - 2019/03/03 Ciência aos Domingos Doenças causadas por micobactérias, da Tuberculose às infecções pulmonares atípicas
2016/12/02 - 2016/12/02 SIC - Jornal da Noite Prémio Santa Casa Neurociências Mantero Belard
2015/12/10 - 2015/12/10 RTP 1 - Jornal da Tarde Descoberta de enzima essencial de Mycobacterium tuberculosis
2015/10/21 - 2015/10/21 Bolsas de Ignição Produção de compostos essenciais para investigação em doenças causadas por micobactérias
2009/10/02 - 2009/10/02 TVI - Jornal da Uma Micróbio resistente a radiações

Mentoring / Tutoring

Topic Student name
2025 - 2025 Environmental–host microbiology at the interface of infection and care Szymon Szerszen, Uniwersytet Wroclawski, Poland
2022 - 2022 Nontuberculous mycobacteria from drinking water Helena Pérez López, University of Alcalá, Spain
2021 - 2021 Identificação de micobactérias não tuberculosas isoladas de água potável Inês Figueiredo, DCV, University of Coimbra
2019 - 2019 Micobactérias oportunistas em redes de distribuição de água Ana Rita Cunha
2019 - 2019 Micobactérias oportunistas domésticas: um perigo para a saúde pública André Simões, DCV, University of Coimbra
2018 - 2018 Estudo da microbiota do pé diabético Beatriz Rito, BSc Biochemistry, UC
2017 - 2017 Chromatographic studies of mycobacterial methylated polysaccharides Catarina Fernandes, DCV, University of Coimbra
2016 - 2016 Purification of a mycobacterial methyltransferase Sara Valente, University of Coimbra
2014 - 2014 Micobacteriologia molecular - purificação de açúcares fosforilados raros Miguel Lopes, University of Coimbra
2014 - 2014 Purification of a mycobacterial maltose-1-phosphate Rita Pereira
2013 - 2013 Isolation and identification of nontuberculous mycobacteria from hospital settings Daniela Nunes Costa, University of Coimbra
2013 - 2013 Cloning and expression of genes of glycogen metabolism in Mycobacterium tuberculosis Aparajita Lahree, IMM, University of Lisbon
2013 - 2013 General protocols in microbiology Alexandra Abrunheiro
2013 - 2013 Quantitative expression of a mycobacterial glucosylglycerate hydrolase Marta Sousa
2012 - 2012 Resistance of Mycobacterium hassiacum to disinfectants Sofia Silva, Universidade de Évora
2012 - 2012 Biosynthesis of a rare polysaccharide from mycobacteria Emanuele Feleppa, University of Sannio, Italy
2012 - 2012 Purification of a mycobacterial octanoyltransferase Luigina Cirelli, University of Sannio, Italy
2011 - 2012 Trehalose biosynthesis in mycobacteria Ana Nobre, University of Coimbra
2011 - 2011 Variabilidade genética da enzima maltocinase Teresa Lino
2010 - 2010 Purificação duma fosfatase de Mycobacterium tuberculosis Vitor Carmona, FFUC, University of Coimbra
2009 - 2009 Metabolismo de trealose e maltose em micobactérias Ana Maranha, University of Coimbra
2008 - 2008 Purificação de uma fosfatase de Petrotoga mobilis Carlos Matos, University of Coimbra
2008 - 2008 Microbiologia de especiarias: isolamento e identificação por biologia molecular Tânia Baptista

Other jury / evaluation

Activity description Institution / Organization
2021/07/20 - Current Ana Isabel Gonçalves Roque, "Blood microbiome: insights into gut barrier function and autoimmunity development in Celiac Disease" - Projecto de Tese e Comissão de Acompanhamento de Tese (CAT), Programa Doutoral em Biologia, Universidade Nova de Lisboa Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11/25 - 2022/11/25 Teresa Paula Marques "Impacto da Microbiota Oral e Intestinal na Infeção Covid-19" Relatório de Ano Probatório do Doutoramento em Ciências Biomédicas do Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/06/01 - 2017/06/01 Marija Petkovic "Antimicrobial peptides (AMP) and microRNA (miR) as synergistic therapy for wound healing". Thesis Project, PhD Programme in Experimental Biology and Biomedicine (PDBEB), Centre for Neuroscience and Cell Biology, University of Coimbra. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/11/10 - 2015/11/10 André Lázaro Correia "Bariatric surgery and gut microbiome shifts: is there a difference between gastric sleeve and gastric bypass?", Projecto de Tese, Programa de Doutoramento em Ciências da Saúde, Faculdade de Medicina, Universidade de Coimbra Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07/16 - 2015/07/16 Pedro Curto "The retropepsin-like enzyme RC1339/APRc from Rickettsiae as a potential therapeutic target for rickettsial diseases", Thesis Project, PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Scientific expedition

Activity description Institution / Organization
2018/06 - 2018/10 Expedition "Domestic NTM - There must be something in the water". Organization and sampling: Nuno Empadinhas, Susana Alarico, Daniela Machado. Coimbra/Aveiro/Braga/Porto Districts. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal
2008/10/23 - 2008/10/25 Expedition "Furnas - Novel thermophiles". Organization: Nuno Empadinhas & Milton S. da Costa. Sampling: Nuno Empadinhas & Sandra M. Cardoso. Furnas, São Miguel Island, Azores Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/09/04 - 2004/09/09 Expedition "Hotspots - Isolation of thermophiles from Azorean Hotsprings for biotechnological applications". Organization: Milton S. da Costa, Nuno Empadinhas, Garabed Antranikian. Sampling: Nuno Empadinhas, Ana Nobre, Rami Al-Khudary, Ksenia Egorova, Moritz Katzer, with technical support by the University of the Azores, Ponta Delgada Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Technische Universität Hamburg Studiendekanat Gewerblich-Technische Wissenschaften, Germany
1998/07/29 - 1998/08/03 Expedition "Keratin - New keratin-degrading thermophiles from hotsprings in São Miguel Island". Organization and sampling: Milton S. da Costa & Nuno Empadinhas, with technical support from the University of the Azores, Ponta Delgada, Azores Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade dos Açores, Portugal
Distinctions

Award

2023 Pfizer Award in Basic Research
Sociedade de Ciências Médicas de Lisboa & Pfizer, Portugal
2020 Prémio Projetos Semente de I&D "Era pós-COVID 19"
Universidade de Coimbra/Santander, Portugal
2017 Thomé Villar Award, Sociedade Portuguesa de Pneumologia & Boehringer Ingelheim
Sociedade Portuguesa de Pneumologia, Portugal
2016 Santa Casa Neurociências Mantero Belard Award
Santa Casa da Misericórdia de Lisboa, Portugal
2012 Mizutani Foundation for Glycoscience - Exploratory Glycoscience Grant
Mizutani Foundation for Glycoscience, Japan, Japan

Other distinction

2025 Best Poster Award - 45th Annual Meeting of the ESM (Senior author)
European Society for Mycobacteriology , Germany
2024 Article featuring the cover of "Natural Product Reports" (Volume 41, December)
Royal Society of Chemistry, United Kingdom
2021 Article featuring the cover of "Antioxidants & Redox Signaling" (Volume 34, Issue 8, March)
Mary Ann Liebert, Inc., publishers, United States
2020 Editor's Choice Article selected for the May Issue of "Microbiology" (Volume 166, Issue 5)
Microbiology Society, United Kingdom
2011 Article featuring the cover of "Molecular Microbiology" (Volume 79, Issue 1, January)
Molecular Microbiology Editorial Board (Wiley Blackwell Publishing), United States