Curriculum Vitae
Manuela Colla Carvalheiro
Identification
Personal identification
- Full name
- Manuela Colla Carvalheiro
Citation names
- Carvalheiro, Manuela
- Carvalheiro, Manuela C
- Carvalheiro, Manuela Colla
Author identifiers
- Ciência ID
- C415-C96F-C9FC
- ORCID iD
- 0000-0002-6028-4717
- Researcher Id
- M-5581-2014
- Scopus Author Id
- 57202998389
Email addresses
- mcarvalheiro@ff.ulisboa.pt (Professional)
Telephones
- Telephone
-
- 217946404 Ext.: 14772 (Professional)
Websites
- http://www.imed.ulisboa.pt/; http://www.ff.ulisboa.pt/ (Professional)
Knowledge fields
- Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
- Engineering and Technology - Nano-technology
- Engineering and Technology - Nano-technology - Nano-materials
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review |
|---|---|---|---|---|---|
| Italian | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | |
| English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Education
| Degree | Classification | |
|---|---|---|
|
2011
Concluded
|
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Liposomes as Nanosystems for the transport and Delivery of Bioactive Agents" (THESIS/DISSERTATION)
|
Distinção e Luovor |
|
2001
Concluded
|
Tecnologia Alimentar / Qualidade (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Ocorrência e Distribuição de Leveduras de Contaminação Alimentar. Identificação e Caracterização Molecular." (THESIS/DISSERTATION)
|
Bom com Distinção |
|
1991
Concluded
|
Química Aplicada - Biotecnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
|
14 |
Affiliation
Science
| Category Host institution |
Employer | |
|---|---|---|
| 2011/03/25 - Current | Auxiliary Researcher (Research) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
| Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal | ||
| 2009/01/01 - 2011/03/24 | Research Assistant (Research) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
| Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal |
Others
| Category Host institution |
Employer | |
|---|---|---|
| 2001/06/01 - 2008/12/31 | Contrato Administrativo de Provimento Assistente de Investigação - Carreira de Investigação | Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal |
| 1999/06/30 - 2001/05/31 | Contrato de trabalho a termo certo Estagiário de Investigação _ Carreira de Investigação | Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal |
| 1998/06/01 - 1999/06/29 | Contrato de Técnico Superior de 2ª classe – Carreira Técnica Superior | Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal |
| 1995/01/01 - 1998/05/31 | Grant - junior researcher | Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal |
| 1992/11/01 - 1994/11/01 | Master student | Fundação para a Ciência e a Tecnologia, Portugal |
| 1991/02/01 - 1992/10/01 | Grant student in PEDIP JTI program | Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal |
Projects
Contract
| Designation | Funders | |
|---|---|---|
| 2021 - 2024 | Targeting TLR2 for improved veterinary vaccines
PTDC/CVT-CVT/4599/2021
|
Fundação para a Ciência e a Tecnologia |
| 2021/01/10 - 2023/06 | Detect, prevent, eradicate: a multi-step strategy to abrogate brain metastasization of breast cancer
FCT-PTDC/MED-ONC/29402/2017
Co-orientador de aluno de PhD que desenvolveu o trabalho experimental para a obtenção do grau no âmbito deste projeto
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2021 - 2023 | Tackling trypanosomiasis cardiomyopathy with microRNAs and tridimensional (3D) cell models
EXPL/CVT-CVT/0175/2021
|
Fundação para a Ciência e a Tecnologia |
| 2018 - 2022 | Sustainable, Safe, and Scalable (3S) approach for lycopene valorization: driving the knowledge toward an academia-industry
interface for topical treatment of inflammation
PTDC/SAU-SER/30197/2017
Researcher
|
Fundação para a Ciência e a Tecnologia |
| 2018 - 2022 | Phage-Enzybiotic : dealing with critical pathogenic antibiotic-resistant bacteria
PTDC/BTM-SAL/28978/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2018 - 2022 | Programming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary
vaccines
C493040443-00089191
PTDC/CVT-CVT/31840/2017
Researcher
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
|
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
|
| 2016 - 2020 | VIH_TRANFERSOME: Inibidor de fusão veiculado em Transfersomas para libertação transdérmica
PGG/006/2016
Researcher
Gilead Génese, Portugal
|
Gilead Génese
Concluded
|
| 2017/09 - 2019/09 | Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
Farm-ID 200009
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Phospholipid Forschungszentrum e V |
| 2013 - 2015 | Priming of Mesenchymal Stromal Cells from the Umbilical Cord Tissue (UC X®) as a Means of Incrementing Their Therapeutic Potency
for Rheumatoid Arthritis
EXPL/DTP-FTO/0308/2013
|
Fundação para a Ciência e a Tecnologia |
| 2013/07 - 2014/12 | Cutaneous leishmaniasis: an innovative idea to explore the topical treatment of skin lesions
EXPL/CVT-EPI/0862/2012
Principal investigator
|
Fundação para a Ciência e a Tecnologia |
| 2012 - 2014 | Helicobacter pylori phages: translating an underestimated phenomenon into a therapeutic application
PTDC/EBB-EBI/119860/2010
|
Fundação para a Ciência e a Tecnologia |
| 2010 - 2012 | Development of new polymer-liposome complexes combining experimental and computational approaches
PTDC/EQU-EPR/099226/2008
|
Fundação para a Ciência e a Tecnologia |
| 2010 - 2012 | A challenge for the treatment of parasitic diseases: rational design of Trifluralin derivatives and appropriate nanoformulations
PTDC/CVT/098290/2008
|
Fundação para a Ciência e a Tecnologia |
| 2005 - 2008 | Microtubule Inhibitor Formulations Against Zoonotic Visceral Leishmaniasis
POCI/CVT/56995/2004
|
Fundação para a Ciência e a Tecnologia |
| 2003 - 2006 | Targeted Antisense Therapy: A Novel Approach for the Treatment of Human Small Cell Lung Cancer
POCTI/FCB/48487/2002
|
Fundação para a Ciência e a Tecnologia |
| 2002 - 2005 | Liposomal Formulations of Dinitroanilines for the Treatment of Canine Leishmaniasis.
POCTI/2000/FCB/35249
|
Fundação para a Ciência e a Tecnologia |
| 1999 - 2000 | SUBERIMUNE_Synthesis of adjuvants for vaccines obtained from wastes of beer and cork industries.
LP089-P31B-05/97
|
Agência Nacional de Inovação SA |
| 1997 - 2000 | Chemically modified immunomodulators associated to colloidal carriers for cancer therapy
Praxis XXI Ref. 2/2.1/SAU/1381/95,
|
Fundação para a Ciência e a Tecnologia |
| 1995 - 2000 | Liposome-Encapsulated Drugs for the Therapy of Leishmanial Infections
Science for Stability PO-INFECTION 941457
|
NATO |
| 1993 - 1996 | Bioconjugados e Vectores para Fins Terapêuticos
PBIC/C/SAU/1551/92
|
Fundação para a Ciência e a Tecnologia |
Outputs
Publications
| Book chapter |
|
| Journal article |
|
| Newspaper article |
|
| Thesis / Dissertation |
|
Activities
Oral presentation
| Presentation title | Event name Host (Event location) |
|
|---|---|---|
| 2019/07/22 | Amphotericin B Deformable Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis | 46th Controlled Release Society (CRS) Annual Meeting and Exposition
Controlled Release Society (Valencia, Spain)
|
| 2017/05/17 | Nanoformulations of trifluralin analogues | 6th World Congress on Leishmaniasis
Instituto de Salud Carlos III; Drugs for Neglected Diseases initiative (DNDi) (Toledo, Spain)
|
| 2016 | Liposomes versus lipid nanoparticles as tools to enhance antileishmanial drugs. | Meeting of WG 1 and 4 on: Targeting metabolism and transport in parasites: drugs and delivery systems. Cost Action 1307:
Chemotherapy Towards Diseases Caused by Endoparasites.
I3S; ICBAS (Porto, Portugal)
|
| 2013/05/16 | Hemi-synthetic dinitroanilines in liposomes: combined strategies for improving treatment of Leishmania infantum infection | 5th World Congress on Leishmaniasis
Oswaldo Cruz Foundation; Brazilian Society of Tropical Medicine; Brazilian Society of Protozoology; Brazilian Society of Parasitology (Porto de Galinhas, Pernambuco, Brazil)
|
| 2011/09/09 | Novel drugs and non-conventional formulations as tools for the treatment of Leishmania infections | New Indigo Workshop – Antiparasitic and Antitumor Drugs
IBMC (Porto, Portugal)
|
| 2009/02/18 | Liposomal Trifluralin and Derivatives as Antileishmanial Agents | 1st Post-Graduated iMed.UL Students Meeting
Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
|
| 2006/10/24 | Antagonist G targeted stabilized antisense-lipid particles (SALP-G): a novel vector for delivery of antisense oligonucleotides to Small Cell Lung Cancer | VII Spanish-Portuguese Conference on Controlled Drug Delivery
Faculty of Pharmacy, University of Navarra (Pamplona, Spain)
|
Supervision
| Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
|---|---|---|
| 2023 - Current | Biogenic Synthesis of Silver Nanoparticles
Co-supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2020/02 - Current | Inside and Beyond the Colour: unveiling the therapeutic potential of topical glycoalkaloids from green tomatoes
Co-supervisor
|
|
| 2019/10/01 - Current | The blood brain barrier in brain metastatization of breast cancer: A source of biomarkers, a target for modulation and an
obstacle to overcome
Co-supervisor
|
Farmácia Ramo Biologia Molecular (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2022 - 2023 | Formulações Lipossomais de Glucocorticóides para o tratamento da Artrite Reumatóide: Preparação, caracterização e avaliação
in vitro.
Supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2022 - 2023 | Transdermal eyelid delivery for treatment of ophtalmic diseases
Co-supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2020/09 - 2021/12 | Preserving the blood-brain barrier: a way of preventing breast cancer brain metastases
Co-supervisor
|
|
| 2019/01/07 - 2019/05/05 | Lipid-based nanoformulations of novel seleno-compounds with anti-leishmania activity.
Design and development of advanced nanoparticulate drug carrier systems for overcoming biological barriers, particularly for
fighting infectious diseases, such as leishmaniasis. Physicochemical, biological (in vitro) and pre-clinical evaluation
of advanced drug therapy systems.
Co-supervisor
|
Farmacia + Nutrición Humana y Dietética (PhD)
Universidad de Navarra Facultad de Farmacia y Nutrición, Spain
|
| 2018 - 2018 | Lipid-Based Colloidal Systems for Skin Delivery of Anti-Leishmanial Drugs
Supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2017/02/12 - 2017/08/05 | Advanced Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis.
To develop and evaluate lipid nanocarriers as systems for topical administration of drugs: - Preparation and physico-chemical
characterization of nanocarriers containing antileishmanial agents - In vitro evaluation of permeation and skin retention
- In vitro evaluation of biological activity ERASMUS Programm
Co-supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2017 - 2017 | Formulations of Ethosomes with Amphotericin B (AmB) as an alternative for Cutaneous Leishmaniasis (CL) Treatment
Supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2015 - 2016 | Lipid-Based Vesicles for Oryzalin Incorporation. Preparation, Characterisation and in vitro Studies
Supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2015 - 2016 | Development and Characterisation of Lipid-Based Systems for a Bioactive Agent
Supervisor
|
Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2013/09 - 2014/02 | Pesquisa de proteínas líticas fágicas e formulações lipossomais para a sua entrega a Helicobacter pylori
Co-supervisor
|
Engenharia Biomédica (Master)
Universidade Católica Portuguesa, Portugal
|
Event participation
| Activity description Type of event |
Event name Institution / Organization |
|
|---|---|---|
| 2007/06/10 - 2007/06/15 | The ESF Summer School has been designed to provide an intensive state-of the- art training across all of the sub-disciplines
of Nanomedicine, and to foster discussion and exchange of ideas. The lectures, tutorials and interactive workshops will particularly
cover all aspects that are needed to transfer new nanotechnologies from bench to bedside – from materials science and engineering
to clinical need, from rational design of nanopharmaceuticals, imaging agents and constructs for tissue engineering to safe
and practical development.
Other
|
1st European Science Foundation Summer School in Nanomedicine
European Science Foundation, France
|
| 2004/08/30 - 2004/09/10 | Post-graduate Course - The course aims to prepare researchers for the appropriate use of animals in scientific experiments.
This theoretical and practical course will cover the biology and husbandry of laboratory animals, aspects of microbiology
and disease, health hazards and safe practices in the animal house, the design and conduct of animal experiments, anaesthesia,
analgesia and experimental procedures, as well as the ethical and legal aspects of animal experimentation and alternatives
to animal use.
Other
|
Course on Laboratory Animal Science (FELASA – LEVEL C)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
| 2003/06/25 - 2003/06/27 | Short Course on Cell and Tissue Culture - The purpose of this short course is to improve the participants' knowledge of
theoretical / practical aspects related to cell and tissue culture.
Other
|
Cell and Tissue Culture
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
| 2000/07/27 - 2000/08/01 | Radiation Safety Course - In order to work with nuclear substances, individuals must have completed the Radiation Safety
Course offered by EHS. EHS trains users and issues Radionuclide Permits under the Canadian Nuclear Safety Commission (CNSC)
Licence issued to the University of Alberta.
Other
|
Radiation Safety Course.
University of Alberta, Canada
|
| 2000/07/13 - 2000/07/14 | The Care and Use of the Laboratory Mouse. Mandatory training course for animal users at the University of Alberta, Edmonton,
Canada.
Other
|
The Care and Use of the Laboratory Mouse
University of Alberta Health Sciences Laboratory Animal Services, Canada
|
| 1999/07/05 - 1999/07/09 | Cytokines
Workshop
|
Cytokines
Instituto Gulbenkian de Ciência, Portugal
|
| 1999/06/24 - 1999/07/05 | Targeting of Drugs: Strategies for Gene Constructs and Deliver - This workshop deals with developments in circumventing
the problems of direct DNA administration by the use of viral or non-viral vectors. Representatives from both camps of therapy
discuss the challenges and opportunities of the two approaches and present the latest progress with a variety of constructs
(viral and non-viral).
Workshop
|
Targeting of Drugs: Strategies for Gene Constructs and Delivery
NATO, Belgium
|
| 1997/06/24 - 1997/07/05 | Targeting of Drugs: Strategies for Stealth Therapeutic Systems - This workshop discusses in great depth the present and
the future of the very importante research field of drug delivery. In particular, deals with a variety of approaches to evade
the reticuloendothelial system and thus extend the circulation time of a variety of delivery systems including polymers, biopolymers,
liposomes, and other nanoparticles or microparticles.
Workshop
|
Targeting of Drugs: Strategies for Stealth Therapeutic Systems
NATO, Belgium
|
| 1995/09/14 - 1995/09/19 | Short Course on: Liposome Technology - Clinical and Industrial Applications.
Workshop
|
Liposome Technology - Clinical and Industrial Applications
Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
|
| 1993/10/11 - 1993/10/13 | Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
Workshop
|
Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
CABI, United Kingdom
|
Jury of academic degree
| Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
|---|---|---|
| 2023/11/22 | Evaluation of Microneedle Arrays as potential delivery systems for bacterial extracellular vesicles
(Thesis) Arguer
|
Miriam Domingos de Sousa (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2022/11/24 | Innovative sporopollenin microgranules delivery system with photoprotective activity
(Thesis) Arguer
|
Isabel Tomás Roça (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2022/11/22 | New Insights in Permeability Studies: Bioprinted 3D Skin Models vs Biological Skin
(Thesis) Arguer
|
Ana Filipa Vinhas Agostinho Matos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2016/09/29 | Nanoencapsulation of New Compounds with Potential Antileishmanial Activity
(Thesis) Arguer
|
Jõao Pedro Vitorino Quintas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
| 2016 | Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão
(Thesis) Main arguer
|
Ana Margarida Ferreira da Silva (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
| 2015 | Management of Skin Cancer by Agonist of 5-HTI A and Antagonist of 5-HT2A receptors
(Thesis) Arguer
|
Ana Catarina da Silva Fernandes Saraiva de Menezes (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Association member
| Society Organization name | Role | |
|---|---|---|
| 2019 - Current | Spanish Portuguese Local Chapter, controlled Release Society |
Course / Discipline taught
| Academic session | Degree Subject (Type) | Institution / Organization | |
|---|---|---|---|
| 2018 - Current | Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório – Categoria B | (Pós-Graduação) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
Mentoring / Tutoring
| Topic | Student name | |
|---|---|---|
| 2021/09/01 - 2023/03 | Development and characterization of an innovative drug delivery platform targeting breast cancer brain metastases | Joana Raquel Aniceto Romão |
Distinctions
Award
| 2019 | Prêmio Octavio Frias de Oliveira 2019 na categoria Inovação Tecnológica em Oncologia
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil
|