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Identification

Personal identification

Full name
Israa Alakhras Aljnadi
Date of birth
1990/01/01
Gender
Female

Citation names

  • Israa M. Aljnadi
  • Aljnadi, I
  • Aljnadi, Israa

Author identifiers

Ciência ID
C318-7400-8BF1
ORCID iD
0000-0003-1721-0373

Email addresses

  • israa.aljnadi@campus.ul.pt (Professional)
  • asrdavid.89@hotmail.com (Personal)

Addresses

  • Av. Prof. Gama Pinto, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 , Lisboa, Lisboa, Portugal (Professional)
  • Av. Eng. Arantes e Oliveira 4, 5th floor, 1900-222, Lisbon, Lisbon, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Arab (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Upper intermediate (B2)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2021/04/01 - 2025/04/01
Ongoing
Ph.D in pharmacy (Pós-Graduação)
Major in Ph.D in pharmaceutical and therapeutic chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/15 - 2020/12/18
Concluded
Master's degree in biopharmaceutical sciences (Mestrado)
Major in Biopharmaceutical sciences
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Bonding Microbial Glycolipids To Medical Grade Silicone Surface For Biofilm Formation Prevention" (THESIS/DISSERTATION)
17
2008/09/01 - 2013/09/13
Concluded
Pharmacy (Bachelor)
Major in Pharmaceutical sciences
Syrian Private University, Syria
"Duchenne muscular dystrophy (DMD) - Diagnosis and Treatment " (THESIS/DISSERTATION)
82.59
Affiliation

Science

Category
Host institution
Employer
2019/09/01 - Current Researcher (Research) Research Institute for Medicines (iMed.ULisboa), Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Other Careers

Category
Host institution
Employer
2017/11/01 - 2018/05/01 Assessor (Farmacêutica) Masters Pharma, Syria
2011/06/01 - 2018/05/01 Assistente (Farmacêutica) Private Pharmacy, Syria
Private organization, Syria
Projects

Grant

Designation Funders
2023 - Current Inquiring the druggability of DNAG4-helicase interactions with small molecules
2022.06099.PTDC
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2020/12/18 Prevention of biofilm formation using glycolipids bonded onto medical devices surface
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Master Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Concluded
Outputs

Publications

Conference abstract
  1. Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "In Silico identification and Synthesis of C-MYC G4 and Helicase Interaction Inhibitors". Paper presented in 2nd Chem & Biochem Student Meetings, Lisbon, 2022.
    Accepted
  2. Bahls, Bárbara; Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "COMPUTER-ASSISTED DESIGN OF INDOLOISOQUINOLINES AS POTENTIAL NEW ANTICANCER DRUGS". Paper presented in CQUL 5th Meeting - Forging Bonds, Lisbon, 2022.
  3. Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "Studies towards the synthesis of 5-NH2 and 11N-substituted indoloisoquinolines". Paper presented in 13th iMED ULisboa Postgraduate Students Meeting, Lisbon, 2022.
    Accepted
  4. Bahls, Bárbara; Israa M. Aljnadi ; Bruno L. Victor; Alexandra Paulo. "Computer-Assisted Design Of Indoloisoquinolines As Potential New Anticancer Drugs". Paper presented in CQUL 5th Meeting - Forging Bonds, Lisboa, 2022.
  5. Aljnadi, I; Paulo, Alexandra; Victor, Bruno. "Computational Screening and Design of G-quadruplex Ligands Targeting c-MYC in Breast Cancer". Paper presented in The Meeting of Young Investigators in Structural Computational Biology (EJIBCE) 2021, IIIV Edition (Portugal, Coimbra), Coimbra, 2021.
  6. Israa M. Aljnadi ; Bruno L. Victor; Alexandra Paulo. "Binding of (Iso)Quinolinyl-Pyridine-2,6-dicarboxamide ligands to G-quadruplexes: a computational approach". Paper presented in iMed.Ulisboa Meeting 2021( ipSC),, Lisboa, 2021.
  7. Aljnadi, I. ; Magalhães, PR; Victor, B; Paulo, Alexandra. "In Silico studies for developing new cancer therapeutics targeting DNA G-quadruplexes". Paper presented in The Computationally Driven Drug Discovery Meeting, CDDD 7th Virtual Meeting,, 2021.
    Published
Conference poster
  1. Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "In Silico identification and Synthesis of C-MYC G4 and Helicase Interaction Inhibitors". Paper presented in 2nd Chem & Biochem Student Meetings, 2022.
  2. Bahls, Bárbara; Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "COMPUTER-ASSISTED DESIGN OF INDOLOISOQUINOLINES AS POTENTIAL NEW ANTICANCER DRUGS". Paper presented in CQUL 5th Meeting - Forging Bonds, 2022.
  3. Israa M Aljnadi; Alexandra Paulo; Bruno L. Victor. "Studies towards the synthesis of 5-NH2 and 11N-substituted indoloisoquinolines". Paper presented in 13th iMED ULisboa Postgraduate Students Meeting, 2022.
  4. Bahls, Bárbara; Bruno L. Victor; Paulo, Alexandra. "Computer-assisted design of indoloisoquinolines as potential DNAG4-Helicase interaction inhibitors". Paper presented in Jornadas Científicas da Universidade de Lisboa, Faculdade de Farmacia, 2022.
  5. Aljnadi, I; Magalhães, PR; Victor, Bruno; Paulo, Alexandra. "Computational Screening and Design of G-quadruplex Ligands Targeting c-MYC in Breast Cancer". Paper presented in The Meeting of Young Investigators in Structural Computational Biology (EJIBCE) 2021, IIIV Edition (Portugal, Coimbra), 2021.
  6. Aljnadi, I; Magalhães, PR; Victor, Bruno; Paulo, Alexandra. "Binding of (Iso)Quinolinyl-Pyridine-2,6-dicarboxamide ligands to G-quadruplexes: a computational approach". Paper presented in iMed.Ulisboa Meeting 2021( ipSC),, 2021.
  7. Aljnadi, Israa; Santos, C.; GoSantos, C.; Gonçalves, L; Bettencourt, A.F.; Costa, F; Ribeinçalves, L; Ribeiro, I.A.C.. "Preventing Bacteria Colonization by PDMS Dopamine-Functionalization With Sophorolipids Biosurfactant Mixture". Paper presented in 10th International Colloids, 2020.
Journal article
  1. Bárbara Bahls; Israa M. Aljnadi; Rita Emídio; Eduarda Mendes; Alexandra Paulo. "G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030969.
    10.3390/biomedicines11030969
  2. Mendes, Eduarda; Bahls, Bárbara; Aljnadi, Israa M.; Paulo, Alexandra. "Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands". Bioorganic & Medicinal Chemistry Letters 72 (2022): 128862. http://dx.doi.org/10.1016/j.bmcl.2022.128862.
    10.1016/j.bmcl.2022.128862
  3. Dardouri, Maïssa; Aljnadi, Israa M.; Deuermeier, Jonas; Santos, Catarina; Costa, Fabiola; Martin, Victor; Fernandes, Maria H.; et al. "Bonding antimicrobial rhamnolipids onto medical grade PDMS: A strategy to overcome multispecies vascular catheter-related infections". Colloids and Surfaces B: Biointerfaces 217 (2022): 112679. http://dx.doi.org/10.1016/j.colsurfb.2022.112679.
    10.1016/j.colsurfb.2022.112679
  4. Eduarda Mendes; Israa M. Aljnadi ; Bárbara Bahls ; Bruno L. Victor; Alexandra Paulo. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/3/300#cite.
    Open access • Published • 10.3390/ph15030300
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/13 Development of G4-helicase interaction inhibitors for cancer therapy Bio3Pharm, French - Portuguese Symposium
IECB ,European Institute of Chemistry and Biology, Pessac, Université de Bordeaux (Bordeaux, France)
2023/06/26 Inhibitors of Helicase-Mediated c-MYC G-quadruplex Unfolding for Cancer Therapy iMed.Ulisboa 14th Meeting 2023(ipSC)
Faculdade de Farmacia (lisbon, Portugal)
2023/01/23 Inhibition of G4-Helicase Interactions: A Promising Approach for Cancer Targeting Therapy The 15th National Organic Chemistry Meeting (15ENQO), and the 8th National Medicinal Chemistry Meeting (8ENQT)
at University of Algarve, Gambelas campus,Faro, Portugal. (Faro, Portugal)
2022/12/21 In Silico Studies and Chemical Synthesis of Ligands Targeting Parallel G-Quadruplexes 3D-BIOINFO-PT- Annual Meeting
The Portuguese Community of Structural Bioinformatics Researchers, ITQB NOVA (lisbon, Portugal)
2021/06/25 In Silico studies for developing new cancer therapeutics targeting DNA G-quadruplexes The Computationally Driven Drug Discovery Meeting, CDDD 7th Virtual Meeting,
Divisione di Chimica Farmaceutica, Società Chimica Italiana (Division of Medicinal Chemistry, Italian Chemical SocietyI) (milano, Italy)

Association member

Society Organization name Role
2017/11/01 - 2018/05/01 As a manager of the development office in Maters Pharma company, I was responsible to manage the communications with the companies of final oncological products around the world. I was in charge of developing and expanding the work of the company by contacting new suppliers and companies in Europe. manager of the development office in Maters Pharma company

Consulting

Activity description Institution / Organization
2011/06/01 - 2018/05/01 As a community pharmacist, I was responsible for medication dispensing, prescription, and preparation. In addition to the patient consultations for OTC. Moreover, I was in charge of pharmacy management as a financial project.
Distinctions

Other distinction

2023 FCT Grant
Fundação para a Ciência e a Tecnologia, Portugal
2018 Grant of Global Platform for Syrian Students
2008 Grant from Syrian Ministry of High Education for degree in pharmacy