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Diana Guimarães. Completed the Doutoramento in Doctoral Program in Chemical and Biological Engineering in 2021 by Universidade do Minho Centro de Engenharia Biológica, Mestrado in Master’s degree in Molecular Genetics in 2015 by Universidade do Minho Centro de Engenharia Biológica and Licenciatura in Bachelor degree in Genetics and Biotechnology in 2012 by Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente. Is Researcher in Solfarcos LDA. Published 10 articles in journals. Has 2 patent registered. Organized 4 event. Participated as Research Fellow in 2 European projects. Works in the areas of Engineering and Technology, with an emphasis on Nanotechnology, and the field of cosmetic and pharmaceutical formulations.
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Identification

Personal identification

Full name
Diana Isabel Pereira Guimarães
Date of birth
1991/10/06
Gender
Female

Citation names

  • Guimarães, Diana

Author identifiers

Ciência ID
C318-447D-F504

Addresses

  • Avenida da Imaculada Conceição 589, 4700-034 , Braga, Braga, Portugal (Professional)

Knowledge fields

  • Engineering and Technology - Industrial Biotechnology
  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2015 - 2021
Concluded
 Doctoral Program in Chemical and Biological Engineering (Doutoramento)
Universidade do Minho Centro de Engenharia Biológica, Portugal
""Development of liposomal formulations for therapeutic applications” " (THESIS/DISSERTATION)
2015
Concluded
 Master’s degree in Molecular Genetics (Mestrado)
Universidade do Minho Centro de Engenharia Biológica, Portugal
"Searching an in vitro cell model to study chemical modulation of melanogenesis by Tamoxifen" (THESIS/DISSERTATION)
 17
2012
Concluded
 Bachelor degree in Genetics and Biotechnology (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
"Isolation and analysis of genetic diversity of entomopathogenic fungi associated with the cultivation of vines in the Douro Region" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2021 - Current Researcher (Research) Solfarcos LDA, Portugal

Others

Category
Host institution 		Employer
2019 - 2021 Scholarship (SFRH/BD/140321/2018) from FCT Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Minho Centro de Engenharia Biológica, Portugal
2017/04/01 - 2019/03/31 Research grant with the Project - FOLSMART ( H2020-NMP-PILOTS-2015 - Grant Agreement n.º 683356). Universidade do Minho Centro de Engenharia Biológica, Portugal
2015/11/01 - 2017/03/31 Research grant with the Project - InFact (FP7-NMP-2013-SME-7 - Grant Agreement nº. 609198) Universidade do Minho Centro de Engenharia Biológica, Portugal
2015/02/15 - 2015/06/15 ERASMUS +, Internship Universiteit Gent Faculteit Farmaceutische Wetenschappen, Belgium
2013/09/01 - 2015/01/31 Master thesis Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2012/02/06 - 2012/06/29 Internship in the field of Molecular Biology. Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
2011/07/04 - 2011/07/22 Summer internship in the field of Molecular Biology Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2017 - 2019 FOLSMART (H2020-NMP-PILOTS-2015)
Grant Agreement n.º 683356
Research Fellow
2015 - 2017 InFact (FP7-NMP-2013-SME-7)
Grant Agreement nº. 609198
Research Fellow

Other

Designation Funders
2019/04 - 2021/11 Liposome production method for high encapsulation efficiencies
POCI-01-0145-FEDER-042847
Researcher
Universidade do Minho Centro de Engenharia Biológica, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Guimarães, Diana. "Plasma Protein Binding Determination of aPegylated Liposomal Methotrexate". Paper presented in 'Young Evotec Scientist Day', 22 Oct 2019, Apuit’s facilities, Verona, Italy., 2019.
  2. Guimarães, Diana. "Rheumatoid Arthritis treatment with targeted MTX encapsulated liposomes reveals specific mRNA signatures". Paper presented in VIII National RNA Meeting: ptRNA2019, Porto, Portugal, 2019.
  3. Guimarães, Diana. "Effect of sucrose on freeze-dried liposomes encapsulating drugs". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery. Coimbra, Portugal,, 2018.
  4. Guimarães, Diana. "Understanding the molecular basis behind hair morphology: development of new strategies to modulate hair from the follicle". Paper presented in CEB Annual Meeting. Braga. Portugal, 2017.
  5. Guimarães, Diana. "Fluorescent quantification of melanin". Paper presented in Designer Biology: From Proteins and Cells to Scaffolds & Materials. Vienna, Austria, 2017.
  6. Guimarães, Diana. "Delivery of cytarabine by pegylated liposomes for efficient, long-term anticancer effects". Paper presented in IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, 2014.
  7. Guimarães, Diana. "Time-dependent effect of tamoxifen on melanogenesis in normal human melanocytes". Paper presented in IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, 2014.
Journal article
  1. Ferreira, Tiago; Rocha, Diana; Freitas, David; Noro, Jennifer; de Castro, Mariana; Roque, Catarina; Guimarães, Diana; et al. "Physicochemical Properties of New Silicone Alternatives Unraveled by Experimental and Molecular Modeling Techniques". Industrial & Engineering Chemistry Research 63 22 (2024): 9715-9731. http://dx.doi.org/10.1021/acs.iecr.4c00886.
    10.1021/acs.iecr.4c00886
  2. Guimarães, Diana; Lager, Franck; Renault, Gilles; Guezguez, Jamil; Burnet, Michael; Cunha, Joana; Cavaco-Paulo, Artur; Nogueira, Eugénia. "Folate-Targeted Liposomal Formulations Improve Effects of Methotrexate in Murine Collagen-Induced Arthritis". Biomedicines 10 2 (2022): 229. http://dx.doi.org/10.3390/biomedicines10020229.
    10.3390/biomedicines10020229
  3. Costa, Cristiana; Fernandes, Bruno; Guimarães, Diana; Nogueira, Eugénia; Martins, Madalena; Matamá, Teresa; Cavaco-Paulo, Artur. "Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation". International Journal of Pharmaceutics 602 (2021): 120653. http://dx.doi.org/10.1016/j.ijpharm.2021.120653.
    10.1016/j.ijpharm.2021.120653
  4. Guimarães, Diana; Cavaco-Paulo, Artur; Nogueira, Eugénia. "Design of liposomes as drug delivery system for therapeutic applications". International Journal of Pharmaceutics (2021): 120571. http://dx.doi.org/10.1016/j.ijpharm.2021.120571.
    10.1016/j.ijpharm.2021.120571
  5. Guimarães, Diana; Noro, Jennifer; Loureiro, Ana; Lager, Franck; Renault, Gilles; Cavaco-Paulo, Artur; Nogueira, Eugénia. "Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy". Biomedicines 8 12 (2020): 630. http://dx.doi.org/10.3390/biomedicines8120630.
    Published • 10.3390/biomedicines8120630
  6. Guimarães, Diana; Noro, Jennifer; Silva, Carla; Cavaco-Paulo, Artur; Nogueira, Eugénia. "Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs". Frontiers in Bioengineering and Biotechnology 7 (2019): http://dx.doi.org/10.3389/fbioe.2019.00424.
    Published • 10.3389/fbioe.2019.00424
  7. Guimarães, Diana; Noro, Jennifer; Loureiro, Ana; Cavaco-Paulo, Artur; Nogueira, Eugénia. "Quantification of drugs encapsulated in liposomes by 1H NMR". Colloids and Surfaces B: Biointerfaces 179 (2019): 414-420. http://dx.doi.org/10.1016/j.colsurfb.2019.03.039.
    10.1016/j.colsurfb.2019.03.039
  8. Cerqueira, Patrícia; Noro, Jennifer; Moura, Sofia; Guimarães, Diana; Silva, Carla; Cavaco-Paulo, Artur; Loureiro, Ana. "PTS micelles for the delivery of hydrophobic methotrexate". International Journal of Pharmaceutics 566 (2019): 282-290. http://dx.doi.org/10.1016/j.ijpharm.2019.05.049.
    10.1016/j.ijpharm.2019.05.049
  9. Nogueira, Eugénia; Sárria, Marisa P.; Azoia, Nuno G.; Antunes, Egipto; Loureiro, Ana; Guimarães, Diana; Noro, Jennifer; et al. "Internalization of Methotrexate Conjugates by Folate Receptor-a". Biochemistry 57 49 (2018): 6780-6786. http://dx.doi.org/10.1021/acs.biochem.8b00607.
    10.1021/acs.biochem.8b00607
  10. Fernandes, Bruno; Matamá, Teresa; Guimarães, Diana; Gomes, Andreia; Cavaco-Paulo, Artur. "Fluorescent quantification of melanin". Pigment Cell & Melanoma Research 29 6 (2016): 707-712. http://dx.doi.org/10.1111/pcmr.12535.
    10.1111/pcmr.12535

Intellectual property

Patent
  1. Guimarães, Diana. 2020. ""Method for production of liposomes"".
Provisional application for patent
  1. 2024. "Stable cosmetic composition, methods and uses thereof".
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014/08/31 - 2014/09/04 Staff member of the GA2014 -62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - Guimarães (Portugal). (2014)
Congress
2014/05/25 - 2014/05/27 Staff member of the IPFB2014 –8thInternational Conference on Polymer and Fiber Biotechnology - Braga (Portugal); (2014)
Conference
2013 - 2013 Staff member of the NEI2013 - European Researchers' Night-September 27th - Braga (Portugal); (2013)
Workshop
2012 - 2012 Staff member of the NEI2012 - European Researchers' Night-September 28th - Braga (Portugal); (2012 - 2012)
Workshop