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Nuno Sepulveda. Completed the Doutoramento in Ciências Biomédicas in 2009 by Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Mestrado in Matemática Aplicada in 2004 by Universidade de Lisboa Instituto Superior Técnico and Licenciatura in Matemática Aplicada e Computação in 2001 by Universidade de Lisboa Instituto Superior Técnico. Published 81 articles in journals. Has 1 book(s). Participated in 1 event(s). Supervised 1 PhD thesis(es). Supervised 6 MSc dissertation(s) e co-supervised 1. Has received 3 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 project(s), Principal investigator in 2 project(s), Researcher in 2 project(s) and Supervisor in 2 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Human Genetics, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Immunology and Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pathology. In their professional activities interacted with 714 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Porto; Biomarker discovery; Stratification of patients; Regulatory T cells; Mathematical modelling; genome-wide association studies; epigenome-wide association studies; gene expression studies; malaria; chronic fatigue syndrome; .
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Identification

Personal identification

Full name
Nuno Henriques dos Santos de Sepulveda

Citation names

  • Sepulveda, Nuno

Author identifiers

Ciência ID
C11D-9BCF-43BF
ORCID iD
0000-0002-8542-1706

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2009
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"How is the T-cell repertoire shaped?" (THESIS/DISSERTATION)
2004
Concluded
 Matemática Aplicada (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Statistical models for the joint action of two genes in complex binary traits" (THESIS/DISSERTATION)
2001
Concluded
 Matemática Aplicada e Computação (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Exact inferential methods for categorical data analysis" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2020/01 - 2021/06 Auxiliary Researcher (Research) Charité Universitätsmedizin Berlin, Germany
2010/11/01 - 2013/10 Postdoc (Research) London School of Hygiene & Tropical Medicine, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2023/10/01 - Current Assistant Professor (University Teacher) Politechnika Warszawska Wydzial Matematyki i Nauk Informacyjnych, Poland
2021/07/01 - 2023/09/30 Visiting Professor (University Teacher) Politechnika Warszawska Wydzial Matematyki i Nauk Informacyjnych, Poland
Politechnika Warszawska Wydzial Matematyki i Nauk Informacyjnych, Poland
2013/11 - 2019/12 Assistant Professor (University Teacher) London School of Hygiene & Tropical Medicine Faculty of Infectious and Tropical Diseases, United Kingdom
London School of Hygiene & Tropical Medicine Faculty of Infectious and Tropical Diseases, United Kingdom
Projects

Grant

Designation Funders
2023/10/01 - Current PvSTATEM - Serological Testing and Treatment for P. vivax: From a Cluster-Randomised Trial in Ethiopia and Madagascar to a Mobile-technology Supported Intervention
101057665
101118697
Co-Principal Investigator (Co-PI)
Politechnika Warszawska, Poland
 European Commission
2020/01 - Current Analysis of high-throughput antibody data for better understanding immunogenetics and epidemiology of malaria
SFRH/BD/147629/2019
Supervisor
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01 - Current Regulatory T cells and their role on the aetiology of Myalgic encephalomyelitis/chronic fatigue syndrome
SFRH/BD/149758/2019
Supervisor
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/07/01 - 2023/06/30 Integrative approach to discover candidate molecular mimicries between human and viral proteins with application to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and post-outbreak sequelae
PPN/ULM/2020/1/00069/U/00001
Principal investigator
Politechnika Warszawska, Poland
 Narodowa Agencja Wymiany Akademickiej
Ongoing
2005/01 - 2008/12 Integrated Modelling of Immunophysiology and Genetics for Complex Autoimmune Diseases
SFRH/BD/19810/2004
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/10 - 2021/09 Analysing antibody responses against EBV-derived antigens as putative biomarkers and candidates for molecular mimicry in ME/CFS
SC036942/53
Principal investigator
ME Research UK
2020/02 - 2021/01 Unraveling Endothelial Function in ME/CFS
Ramsay Award
Researcher
Solve ME CFS Initiative
Ongoing
2016/05 - 2017/09 Zika: Zika virus surveillance in human and mosquito populations in Cape Verde
ZK/16-097
Researcher
Medical Research Council
Concluded
2016/01 - 2016/12 Feasibility of a serological assay for malaria elimination certification in Cape Verde
OPP1137997
Principal investigator
Bill & Melinda Gates Foundation
Outputs

Publications

Book
  1. Correia, C.; Sepúlveda, N.; Paulino, C.D.. Bayesian genetic mapping of binary trait loci. 2013.
    10.1007/978-3-642-34904-1_14
Book chapter
  1. André Fonseca; Clara Cordeiro; Nuno Sepúlveda. "Identification of Antibody Responses Predictive of Protection Against Clinical Malaria". 2022.
    10.1007/978-3-031-12766-3_16
  2. João Malato; Luís Graça; Nuno Sepúlveda. "Impact of Misclassification and Imperfect Serological Tests in Association Analyses of ME/CFS Applied to COVID-19 Data". 2022.
    10.1007/978-3-031-12766-3_15
  3. Nuno Sepúlveda. "How to Increase the Visibility of Statisticians in the Modern World of Dataism?". 2022.
    10.1007/978-3-031-12766-3_1
Conference paper
  1. Domingues, T.D.; Mouriño, H.; Sepúlveda, N.. "A statistical analysis of serological data from the UK myalgic encephalomyelitis/chronic fatigue syndrome BioBank". 2020.
    10.1063/5.0026633
Journal article
  1. André Fonseca; Mateusz Szysz; Hoang Thien Ly; Clara Cordeiro; Nuno Sepúlveda. "IgG Antibody Responses to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Their Effective Potential for Disease Diagnosis and Pathological Antigenic Mimicry". Medicina (2024): https://doi.org/10.3390/medicina60010161.
    10.3390/medicina60010161
  2. Tiago Dias-Domingues; Helena Mouriño; Nuno Sepúlveda. "Classification Methods for the Serological Status Based on Mixtures of Skew-Normal and Skew-t Distributions". Mathematics (2024): https://doi.org/10.3390/math12020217.
    10.3390/math12020217
  3. Anna D. Grabowska; Mateusz Watroba; Joanna Witkowska; Agnieszka Mikulska; Nuno Sepúlveda; Dariusz Szukiewicz. "Interplay between Systemic Glycemia and Neuroprotective Activity of Resveratrol in Modulating Astrocyte SIRT1 Response to Neuroinflammation". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241411640.
    10.3390/ijms241411640
  4. Inês Cunha Machado; Telmo Nunes; Miguel Maximino; João Malato; Luís Tavares; Almeida V.; Nuno Sepúlveda; Solange Gil. "Epidemiologic Factors Supporting Triage of Infected Dog Patients Admitted to a Veterinary Hospital Biological Isolation and Containment Unit". Veterinary Sciences 10 3 (2023): 186-186. http://dx.doi.org/10.3390/vetsci10030186.
    10.3390/vetsci10030186
  5. Eric William Rogier; Emanuele Giorgi; Kevin Tetteh; Nuno Sepúlveda. "Editorial: Current research on serological analyses of infectious diseases". Frontiers in Medicine 10 (2023): http://dx.doi.org/10.3389/fmed.2023.1154584.
    10.3389/fmed.2023.1154584
  6. João Malato; Luís Graça; Nuno Sepúlveda. "Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Diagnostics (2023): https://doi.org/10.3390/diagnostics13030531.
    10.3390/diagnostics13030531
  7. "Editorial: Current Insights Into Complex Post-infection Fatigue Syndromes With Unknown Aetiology: The Case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Beyond.". Frontiers in medicine (2022): https://europepmc.org/articles/PMC8907997.
    10.3389/fmed.2022.862953
  8. "Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.". Frontiers in neurology (2021): https://europepmc.org/articles/PMC8710546.
    10.3389/fneur.2021.789784
  9. Nuno Sepúlveda. "Impact of genetic variation on the molecular mimicry between Anoctamin-2 and Epstein-Barr virus nuclear antigen 1 in Multiple Sclerosis". Immunology Letters 238 (2021): 29-31. https://doi.org/10.1016/j.imlet.2021.07.007.
    10.1016/j.imlet.2021.07.007
  10. Domingues TD; Grabowska AD; Lee JS; Ameijeiras-Alonso J; Westermeier F; Scheibenbogen C; Cliff JM; et al. "Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.". Frontiers in medicine (2021): http://europepmc.org/abstract/med/34291062.
    10.3389/fmed.2021.686736
  11. Surendran P; Feofanova EV; Lahrouchi N; Ntalla I; Karthikeyan S; Cook J; Chen L; et al. "Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.". Nature genetics (2021): http://europepmc.org/abstract/med/33727701.
    10.1038/s41588-021-00832-z
  12. Nacul L; Authier FJ; Scheibenbogen C; Lorusso L; Helland IB; Martin JA; Sirbu CA; et al. "European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.". Medicina (Kaunas, Lithuania) (2021): http://europepmc.org/abstract/med/34069603.
    10.3390/medicina57050510
  13. Blauensteiner J; Bertinat R; León LE; Riederer M; Sepúlveda N; Westermeier F. "Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.". Scientific reports (2021): http://europepmc.org/abstract/med/34011981.
    10.1038/s41598-021-89834-9
  14. Nolder D; Stewart L; Tucker J; Ibrahim A; Gray A; Corrah T; Gallagher C; et al. "Failure of rapid diagnostic tests in Plasmodium falciparum malaria cases among travelers to the UK and Ireland: Identification and characterisation of the parasites.". International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2021): http://europepmc.org/abstract/med/33991679.
    10.1016/j.ijid.2021.05.008
  15. Szklarski M; Freitag H; Lorenz S; Becker SC; Sotzny F; Bauer S; Hartwig J; et al. "Delineating the Association Between Soluble CD26 and Autoantibodies Against G-Protein Coupled Receptors, Immunological and Cardiovascular Parameters Identifies Distinct Patterns in Post-Infectious vs. Non-Infection-Triggered Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.". Frontiers in immunology (2021): http://europepmc.org/abstract/med/33889154.
    10.3389/fimmu.2021.644548
  16. Sepúlveda N; Grignard L; Curry J; Mahey L; Bastiaens GJH; Tiono AB; Okebe J; et al. "G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials.". Frontiers in genetics (2021): http://europepmc.org/abstract/med/33897764.
    10.3389/fgene.2021.645688
  17. Grignard L; Nolder D; Sepulveda N; Berhane A; Mihreteab S; Kaaya R; Phelan J; et al. "Corrigendum to 'A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections'.". EBioMedicine (2021): http://europepmc.org/abstract/med/33639399.
    10.1016/j.ebiom.2021.103261
  18. Surendran P; Feofanova EV; Lahrouchi N; Ntalla I; Karthikeyan S; Cook J; Chen L; et al. "Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.". Nature genetics (2020): http://europepmc.org/abstract/med/33230300.
    10.1038/s41588-020-00713-x
  19. Moreira da Silva J; Prata S; Domingues TD; Leal RO; Nunes T; Tavares L; Almeida V; Sepúlveda N; Gil S. "Detection and modeling of anti-Leptospira IgG prevalence in cats from Lisbon area and its correlation to retroviral infections, lifestyle, clinical and hematologic changes.". Veterinary and animal science (2020): http://europepmc.org/abstract/med/33204894.
    10.1016/j.vas.2020.100144
  20. van den Hoogen LL; Bareng P; Alves J; Reyes R; Macalinao M; Rodrigues JM; Fernandes JM; et al. "Comparison of Commercial ELISA Kits to Confirm the Absence of Transmission in Malaria Elimination Settings.". Frontiers in public health (2020): http://europepmc.org/abstract/med/33014975.
    10.3389/fpubh.2020.00480
  21. Estévez-López F; Mudie K; Wang-Steverding X; Bakken IJ; Ivanovs A; Castro-Marrero J; Nacul L; et al. "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology.". Journal of clinical medicine (2020): http://europepmc.org/abstract/med/32455633.
    10.3390/jcm9051557
  22. Lindsey Wu; Tom Hall; Isaac Ssewanyana; Tate Oulton; Catriona Patterson; Hristina Vasileva; Susheel Singh; et al. "Optimisation and standardisation of a multiplex immunoassay of diverse Plasmodium falciparum antigens to assess changes in malaria transmission using sero-epidemiology [version 2; peer review: 2 approved]". (2020): https://wellcomeopenresearch.org/articles/4-26/v2.
    10.12688/wellcomeopenres.14950.2
  23. Stresman G; Sepúlveda N; Fornace K; Grignard L; Mwesigwa J; Achan J; Miller J; et al. "Association between the proportion of Plasmodium falciparum and Plasmodium vivax infections detected by passive surveillance and the magnitude of the asymptomatic reservoir in the community: a pooled analysis of paired health facility and community data.". The Lancet. Infectious diseases 20 8 (2020): 953-963. http://europepmc.org/abstract/med/32277908.
    10.1016/s1473-3099(20)30059-1
  24. Butcher R; Handley B; Garae M; Taoaba R; Pickering H; Bong A; Sokana O; et al. "Ocular Chlamydia trachomatis infection, anti-Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma.". The Journal of infection (2020): http://europepmc.org/abstract/med/32017971.
    10.1016/j.jinf.2020.01.015
  25. van den Hoogen LL; Présumé J; Romilus I; Mondélus G; Elismé T; Sepúlveda N; Stresman G; et al. "Quality control of multiplex antibody detection in samples from large-scale surveys: the example of malaria in Haiti.". Scientific reports (2020): http://europepmc.org/abstract/med/31980693.
    10.1038/s41598-020-57876-0
  26. Campos M; Ward D; Morales R; Gomes A; Silva K; Sepúlveda N; Gomez L; et al. "Surveillance of Aedes aegypti populations in the city of Praia, Cape Verde: Zika virus infection, insecticide resistance and genetic diversity". Parasites & vectors 13 1 (2020): http://europepmc.org/abstract/PMC/PMC7507728.
    10.1186/s13071-020-04356-z
  27. Grignard, L.; Nolder, D.; Sepúlveda, N.; Berhane, A.; Mihreteab, S.; Kaaya, R.; Phelan, J.; et al. "A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections". EBioMedicine 55 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085111459&partnerID=MN8TOARS.
    10.1016/j.ebiom.2020.102757
  28. Grabowska, A.D.; Lacerda, E.M.; Nacul, L.; Sepúlveda, N.. "Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Pediatrics 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087114359&partnerID=MN8TOARS.
    10.3389/fped.2020.00293
  29. Phelan, J.; Grabowska, A.D.; Sepúlveda, N.. "A potential antigenic mimicry between viral and human proteins linking Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with autoimmunity: The case of HPV immunization". Autoimmunity Reviews 19 4 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082180094&partnerID=MN8TOARS.
    10.1016/j.autrev.2020.102487
  30. Sepúlveda N; Carneiro J; Lacerda E; Nacul L. "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections.". Frontiers in immunology (2019): http://europepmc.org/abstract/med/31824487.
    10.3389/fimmu.2019.02684
  31. Subissi L; Kanoi BN; Balikagala B; Egwang TG; Oguike M; Verra F; Proietti C; et al. "Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda.". Transactions of the Royal Society of Tropical Medicine and Hygiene (2019): http://europepmc.org/abstract/med/30953444.
    10.1093/trstmh/trz015
  32. Cliff JM; King EC; Lee JS; Sepúlveda N; Wolf AS; Kingdon C; Bowman E; et al. "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).". Frontiers in immunology (2019): http://europepmc.org/abstract/med/31057538.
    10.3389/fimmu.2019.00796
  33. Strand, E.B.; Nacul, L.; Mengshoel, A.M.; Helland, I.B.; Grabowski, P.; Krumina, A.; Alegre-Martin, J.; et al. "Myalgic encephalomyelitis/chronic fatigue Syndrome (ME/CFS): Investigating care practices pointed out to disparities in diagnosis and treatment across European Union". PLoS ONE 14 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076271052&partnerID=MN8TOARS.
    10.1371/journal.pone.0225995
  34. Wu, L.; Hall, T.; Ssewanyana, I.; Oulton, T.; Patterson, C.; Vasileva, H.; Singh, S.; et al. "Optimisation and standardisation of a multiplex immunoassay of diverse plasmodium falciparum antigens to assess changes in malaria transmission using sero-epidemiology [version 1; peer review: 2 approved with reservations]". Wellcome Open Research 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073065404&partnerID=MN8TOARS.
    10.12688/wellcomeopenres.14950.1
  35. Giri A; Hellwege JN; Keaton JM; Park J; Qiu C; Warren HR; Torstenson ES; et al. "Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.". Nature genetics (2018): http://europepmc.org/abstract/med/30578418.
    10.1038/s41588-018-0303-9
  36. Vila Nova B; Cunha E; Sepúlveda N; Oliveira M; São Braz B; Tavares L; Almeida V; Gil S. "Evaluation of the humoral immune response induced by vaccination for canine distemper and parvovirus: a pilot study.". BMC veterinary research (2018): http://europepmc.org/abstract/med/30445957.
    10.1186/s12917-018-1673-z
  37. Estévez-López F; Castro-Marrero J; Wang X; Bakken IJ; Ivanovs A; Nacul L; Sepúlveda N; et al. "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe-the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review.". BMJ open (2018): http://europepmc.org/abstract/med/30181183.
    10.1136/bmjopen-2017-020817
  38. Nuno Sepúlveda; Jody Phelan; Ernest Diez-Benavente; Susana Campino; Taane G. Clark; Heidi Hopkins; Colin Sutherland; Chris J. Drakeley; Khalid B. Beshir. "Global analysis of Plasmodium falciparum histidine-rich protein-2 (pfhrp2) and pfhrp3 gene deletions using whole-genome sequencing data and meta-analysis". Infection, Genetics and Evolution 62 (2018): 211-219. https://doi.org/10.1016/j.meegid.2018.04.039.
    10.1016/j.meegid.2018.04.039
  39. Ndila CM; Uyoga S; Macharia AW; Nyutu G; Peshu N; Ojal J; Shebe M; et al. "Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.". The Lancet. Haematology (2018): http://europepmc.org/abstract/med/30033078.
    10.1016/S2352-3026(18)30107-8
  40. Voak AA; Standing JF; Sepúlveda N; Harris A; Croft SL; Seifert K. "Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages.". The Journal of antimicrobial chemotherapy (2018): http://europepmc.org/abstract/med/29506127.
    10.1093/jac/dky014
  41. Matt Ravenhall; Scott M. Williams; Susana Campino; Nuno Sepúlveda; Alphaxard Manjurano; Behzad Nadjm; George Mtove; et al. "Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania". PLOS Genetics 14 1 (2018): e1007172-e1007172. https://doi.org/10.1371/journal.pgen.1007172.
    10.1371/journal.pgen.1007172
  42. Guelbéogo WM; Gonçalves BP; Grignard L; Bradley J; Serme SS; Hellewell J; Lanke K; et al. "Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission.". eLife (2018): http://europepmc.org/abstract/med/29357976.
    10.7554/eLife.32625
  43. Migchelsen SJ; Sepúlveda N; Martin DL; Cooley G; Gwyn S; Pickering H; Joof H; et al. "Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia.". Scientific reports (2017): http://europepmc.org/abstract/med/29118442.
    10.1038/s41598-017-15056-7
  44. Beshir KB; Sepúlveda N; Bharmal J; Robinson A; Mwanguzi J; Busula AO; de Boer JG; et al. "Plasmodium falciparum parasites with histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in two endemic regions of Kenya.". Scientific reports (2017): http://europepmc.org/abstract/med/29116127.
    10.1038/s41598-017-15031-2
  45. Farías JG; Carrasco-Pozo C; Carrasco Loza R; Sepúlveda N; Álvarez P; Quezada M; Quiñones J; Molina V; Castillo RL. "Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2.". (2017): http://europepmc.org/abstract/med/27190274.
    10.1177/1535370216649263
  46. Sepúlveda N; Manjurano A; Campino SG; Lemnge M; Lusingu J; Olomi R; Rockett KA; et al. "Malaria host candidate genes validated by association with current, recent and historic measures of transmission intensity.". (2017): http://europepmc.org/abstract/med/28541483.
    10.1093/infdis/jix250
  47. Clarke GM; Rockett K; Kivinen K; Hubbart C; Jeffreys AE; Rowlands K; Jallow M; et al. "Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.". eLife 6 (2017): http://europepmc.org/abstract/med/28067620.
    10.7554/elife.15085
  48. Dewasurendra RL; Dias JN; Sepulveda N; Gunawardena GS; Chandrasekharan N; Drakeley C; Karunaweera ND. "Effectiveness of a serological tool to predict malaria transmission intensity in an elimination setting.". (2017): http://europepmc.org/abstract/med/28068925.
    10.1186/s12879-016-2164-0
  49. Sepúlveda N; Morais CG; Mourão LC; Freire MF; Fontes CJ; Lacerda MV; Drakeley CJ; Braga ÉM. "Allele-specific antibodies to Plasmodium vivax merozoite surface protein-1: prevalence and inverse relationship to haemoglobin levels during infection.". (2016): http://europepmc.org/abstract/med/27852258.
    10.1186/s12936-016-1612-z
  50. Ravenhall M; Benavente ED; Mipando M; Jensen AT; Sutherland CJ; Roper C; Sepúlveda N; et al. "Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi.". (2016): http://europepmc.org/abstract/med/27899115.
    10.1186/s12936-016-1634-6
  51. Ullah K; Khan NH; Sepúlveda N; Munir A; Wahid S. "Assessing Incidence Patterns and Risk Factors for Cutaneous Leishmaniasis in Peshawar Region, Khyber Pakhtunkhwa, Pakistan.". (2016): http://europepmc.org/abstract/med/27310301.
    10.1645/15-919
  52. Wahid S; Stresman GH; Kamal SS; Sepulveda N; Kleinschmidt I; Bousema T; Drakeley C. "Heterogeneous malaria transmission in long-term Afghan refugee populations: a cross-sectional study in five refugee camps in northern Pakistan.". (2016): http://europepmc.org/abstract/med/27121196.
    10.1186/s12936-016-1305-7
  53. Canton, G.C.; Bertolazi, A.A.; Cogo, A.J.D.; Eutrópio, F.J.; Melo, J.; de Souza, S.B.; A. Krohling, C.; et al. "Biochemical and ecophysiological responses to manganese stress by ectomycorrhizal fungus Pisolithus tinctorius and in association with Eucalyptus grandis". Mycorrhiza 26 5 (2016): 475-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957686854&partnerID=MN8TOARS.
    10.1007/s00572-016-0686-3
  54. Uyoga S; Ndila CM; Macharia AW; Nyutu G; Shah S; Peshu N; Clarke GM; et al. "Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.". (2015): http://europepmc.org/abstract/med/26686045.
    10.1016/s2352-3026(15)00152-0
  55. Manjurano A; Sepulveda N; Nadjm B; Mtove G; Wangai H; Maxwell C; Olomi R; et al. "African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.". (2015): http://europepmc.org/abstract/med/25671784.
    10.1371/journal.pgen.1004960
  56. Manjurano, A.; Sepulveda, N.; Nadjm, B.; Mtove, G.; Wangai, H.; Maxwell, C.; Olomi, R.; et al. "USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania". Journal of Infectious Diseases 212 7 (2015): 1129-1139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943383427&partnerID=MN8TOARS.
    10.1093/infdis/jiv192
  57. Mangano, V.D.; Kabore, Y.; Bougouma, E.C.; Verra, F.; Sepulveda, N.; Bisseye, C.; Santolamazza, F.; et al. "Novel Insights into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia". Journal of Infectious Diseases 212 4 (2015): 626-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939628640&partnerID=MN8TOARS.
    10.1093/infdis/jiv098
  58. Shelton, J.M.G.; Corran, P.; Risley, P.; Silva, N.; Hubbart, C.; Jeffreys, A.; Rowlands, K.; et al. "Genetic determinants of anti-malarial acquired immunity in a large multi-centre study". Malaria Journal 14 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940473563&partnerID=MN8TOARS.
    10.1186/s12936-015-0833-x
  59. Sepúlveda, N.; Drakeley, C.. "Sample size determination for estimating antibody seroconversion rate under stable malaria transmission intensity". Malaria Journal 14 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928749946&partnerID=MN8TOARS.
    10.1186/s12936-015-0661-z
  60. Sepúlveda N; Paulino CD; Drakeley C. "Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate.". (2015): http://europepmc.org/abstract/med/26715538.
    10.1186/s12936-015-1050-3
  61. Sepúlveda N; Stresman G; White MT; Drakeley CJ. "Current Mathematical Models for Analyzing Anti-Malarial Antibody Data with an Eye to Malaria Elimination and Eradication.". (2015): http://europepmc.org/abstract/PMC/PMC4684866.
    10.1155/2015/738030
  62. Leal, R.O.; Gil, S.; Duarte, A.; McGahie, D.; Sepúlveda, N.; Niza, M.M.R.E.; Tavares, L.. "Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega". Research in Veterinary Science 99 (2015): 87-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925047702&partnerID=MN8TOARS.
    10.1016/j.rvsc.2015.02.008
  63. van den Hoogen LL; Griffin JT; Cook J; Sepúlveda N; Corran P; Conway DJ; Milligan P; et al. "Serology describes a profile of declining malaria transmission in Farafenni, The Gambia.". (2015): http://europepmc.org/abstract/med/26492873.
    10.1186/s12936-015-0939-1
  64. Rockett, K.A.; Clarke, G.M.; Fitzpatrick, K.; Hubbart, C.; Jeffreys, A.E.; Rowlands, K.; Craik, R.; et al. "Reappraisal of known malaria resistance loci in a large multicenter study". Nature Genetics 46 11 (2014): 1197-1204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908885451&partnerID=MN8TOARS.
    10.1038/ng.3107
  65. Maiga, B.; Dolo, A.; Campino, S.; Sepulveda, N.; Corran, P.; Rockett, K.A.; Troye-Blomberg, M.; Doumbo, O.K.; Clark, T.G.. "Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali". Malaria Journal 13 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84904082257&partnerID=MN8TOARS.
    10.1186/1475-2875-13-270
  66. Guindani, M.; Sepúlveda, N.; Paulino, C.D.; Müller, P.. "A Bayesian semiparametric approach for the differential analysis of sequence counts data". Journal of the Royal Statistical Society. Series C: Applied Statistics 63 3 (2014): 385-404. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897601214&partnerID=MN8TOARS.
    10.1111/rssc.12041
  67. Cunha, M.G.; Silva, E.S.; Sepúlveda, N.; Costa, S.P.T.; Saboia, T.C.; Guerreiro, J.F.; Póvoa, M.M.; et al. "Serologically defined variations in malaria endemicity in Pará state, Brazil". PLoS ONE 9 11 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84912572245&partnerID=MN8TOARS.
    10.1371/journal.pone.0113357
  68. Sepúlveda, N.; Manjurano, A.; Drakeley, C.; Clark, T.G.. "On the performance of multiple imputation based on chained equations in tackling missing data of the African a3.7-globin deletion in a malaria association study". Annals of Human Genetics 78 4 (2014): 277-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902576887&partnerID=MN8TOARS.
    10.1111/ahg.12065
  69. Leal, R.O.; Gil, S.; Sepúlveda, N.; Mcgahie, D.; Duarte, A.; Niza, M.M.R.E.; Tavares, L.. "Monitoring acute phase proteins in retrovirus infected cats undergoing feline interferon-¿ therapy". Journal of Small Animal Practice 55 1 (2014): 39-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891662246&partnerID=MN8TOARS.
    10.1111/jsap.12160
  70. Gil, S.; Leal, R.O.; McGahie, D.; Sepúlveda, N.; Duarte, A.; Niza, M.M.R.E.; Tavares, L.. "Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats: Clinical and laboratory evaluation". Research in Veterinary Science 96 1 (2014): 79-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892515242&partnerID=MN8TOARS.
    10.1016/j.rvsc.2013.11.007
  71. Maiga, B.; Dolo, A.; Touré, O.; Dara, V.; Tapily, A.; Campino, S.; Sepulveda, N.; et al. "Fc gamma Receptor IIa-H131R polymorphism and malaria susceptibility in sympatric ethnic groups, Fulani and Dogon of Mali". Scandinavian Journal of Immunology 79 1 (2014): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890867847&partnerID=MN8TOARS.
    10.1111/sji.12122
  72. Gil, S.; Leal, R.O.; Duarte, A.; McGahie, D.; Sepúlveda, N.; Siborro, I.; Cravo, J.; Cartaxeiro, C.; Tavares, L.M.. "Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter". Research in Veterinary Science 94 3 (2013): 753-763. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876157116&partnerID=MN8TOARS.
    10.1016/j.rvsc.2012.09.025
  73. Sepúlveda, N.; Campino, S.G.; Assefa, S.A.; Sutherland, C.J.; Pain, A.; Clark, T.G.. "A Poisson hierarchical modelling approach to detecting copy number variation in sequence coverage data". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874209491&partnerID=MN8TOARS.
    10.1186/1471-2164-14-128
  74. Maiga, B.; Dolo, A.; Touré, O.; Dara, V.; Tapily, A.; Campino, S.; Sepulveda, N.; et al. "Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali". PLoS ONE 8 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884848454&partnerID=MN8TOARS.
    10.1371/journal.pone.0075675
  75. Gomes-Santos, C.S.S.; Itoe, M.A.; Afonso, C.; Henriques, R.; Gardner, R.; Sepúlveda, N.; Simões, P.D.; et al. "Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855461427&partnerID=MN8TOARS.
    10.1371/journal.pone.0029408
  76. Manjurano, A.; Clark, T.G.; Nadjm, B.; Mtove, G.; Wangai, H.; Sepulveda, N.; Campino, S.G.; et al. "Candidate Human Genetic Polymorphisms and Severe Malaria in a Tanzanian Population". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868092905&partnerID=MN8TOARS.
    10.1371/journal.pone.0047463
  77. Toure, O.; Konate, S.; Sissoko, S.; Niangaly, A.; Barry, A.; Sall, A.H.; Diarra, E.; et al. "Candidate Polymorphisms and Severe Malaria in a Malian Population". PLoS ONE 7 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866020850&partnerID=MN8TOARS.
    10.1371/journal.pone.0043987
  78. Nunes-Cabaço, H.; Caramalho, I.; Sepúlveda, N.; Sousa, A.E.. "Differentiation of human thymic regulatory T cells at the double positive stage". European Journal of Immunology 41 12 (2011): 3604-3614. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255164181&partnerID=MN8TOARS.
    10.1002/eji.201141614
  79. Sepúlveda, N.; Paulino, C.D.; Carneiro, J.. "Estimation of T-cell repertoire diversity and clonal size distribution by Poisson abundance models". Journal of Immunological Methods 353 1-2 (2010): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649270288&partnerID=MN8TOARS.
    10.1016/j.jim.2009.11.009
  80. Larsen, R.; Gozzelino, R.; Jeney, V.; Tokaji, L.; Bozza, F.A.; Japiassú, A.M.; Bonaparte, D.; et al. "A central role for free heme in the pathogenesis of severe sepsis". Science Translational Medicine 2 51 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77958023093&partnerID=MN8TOARS.
    10.1126/scitranslmed.3001118
  81. Sambo, M.R.; Trovoada, M.J.; Benchimol, C.; Quinhentos, V.; Gonçalves, L.; Velosa, R.; Marques, M.I.; et al. "Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children". PLoS ONE 5 6 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77955253432&partnerID=MN8TOARS.
    10.1371/journal.pone.0011141
  82. Sepúlveda, N.; Paulino, C.D.; Penha-Gonçalves, C.. "Bayesian analysis of allelic penetrance models for complex binary traits". Computational Statistics and Data Analysis 53 4 (2009): 1271-1283. http://www.scopus.com/inward/record.url?eid=2-s2.0-58549091471&partnerID=MN8TOARS.
    10.1016/j.csda.2008.10.038
  83. Ramos, A.C.; Martins, M.A.; Okorokova-Façanha, A.L.; Olivares, F.L.; Okorokov, L.A.; Sepúlveda, N.; Feijó, J.A.; Façanha, A.R.. "Arbuscular mycorrhizal fungi induce differential activation of the plasma membrane and vacuolar H+ pumps in maize roots". Mycorrhiza 19 2 (2009): 69-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449089904&partnerID=MN8TOARS.
    10.1007/s00572-008-0204-3
  84. Souto-Carneiro, M.M.; Fritsch, R.; Sepúlveda, N.; Lagareiro, M.J.; Morgado, N.; Longo, N.S.; Lipsky, P.E.; et al. "The NF-¿B canonical pathway is involved in the control of the exonucleolytic processing of coding ends during V(D)J recombination". Journal of Immunology 180 2 (2008): 1040-1049. http://www.scopus.com/inward/record.url?eid=2-s2.0-40449110380&partnerID=MN8TOARS.
    10.4049/jimmunol.180.2.1040
  85. Gil, S.; Sepúlveda, N.; Albina, E.; Leitão, A.; Martins, C.. "The low-virulent African swine fever virus (ASFV/NH/P68) induces enhanced expression and production of relevant regulatory cytokines (IFNa, TNFa and IL12p40) on porcine macrophages in comparison to the highly virulent ASFV/L60". Archives of Virology 153 10 (2008): 1845-1854. http://www.scopus.com/inward/record.url?eid=2-s2.0-53849098897&partnerID=MN8TOARS.
    10.1007/s00705-008-0196-5
  86. Carneiro, J.; Leon, K.; Caramalho, Í.; Van Den Dool, C.; Gardner, R.; Oliveira, V.; Bergman, M.-L.; et al. "When three is not a crowd: A Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells". Immunological Reviews 216 1 (2007): 48-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947192440&partnerID=MN8TOARS.
    10.1111/j.1600-065X.2007.00487.x
  87. Sepúlveda, N.; Paulino, C.D.; Carneiro, J.; Penha-Gonçalves, C.. "Allelic penetrance approach as a tool to model two-locus interaction in complex binary traits". Heredity 99 2 (2007): 173-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547151518&partnerID=MN8TOARS.
    10.1038/sj.hdy.6800979
  88. Boucontet L; Sepúlveda N; Carneiro J; Pereira P; Boucontet, L.; Sepúlveda, N.; Carneiro, J.; Pereira, P.. "Mechanisms controlling termination of V-J recombination at the TCRgamma locus: implications for allelic and isotypic exclusion of TCRgamma chains.". Journal of Immunology 174 7 (2005): 3912-3919. http://europepmc.org/abstract/med/15778346.
    10.4049/jimmunol.174.7.3912
  89. Sepúlveda, N.; Boucontet, L.; Pereira, P.; Carneiro, J.. "Stochastic Modeling of T cell receptor ¿ gene rearrangement". Journal of Theoretical Biology 234 2 (2005): 153-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744292687&partnerID=MN8TOARS.
    10.1016/j.jtbi.2004.11.018
  90. Campino, S.; Bagot, S.; Bergman, M.-L.; Almeida, P.; Sepúlveda, N.; Pied, S.; Penha-Gonçlves, C.; Holmberg, D.; Cazenave, P.-A.. "Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity". Genes and Immunity 6 5 (2005): 416-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-22544439407&partnerID=MN8TOARS.
    10.1038/sj.gene.6364219
  91. Gil, S.; Spagnuolo-Weaver, M.; Canals, A.; Sepúlveda, N.; Oliveira, J.; Aleixo, A.; Allan, G.; Leitão, A.; Martins, C.L.V.. "Expression at mRNA level of cytokines and A238L gene in porcine blood-derived macrophages infected in vitro with African swine fever virus (ASFV) isolates of different virulence". Archives of Virology 148 11 (2003): 2077-2097. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344736782&partnerID=MN8TOARS.
    10.1007/s00705-003-0182-x
  92. Orge, L.; Galo, A.; Sepúlveda, N.; Simas, J.P.; Pires, M.; Orge L; Galo A; et al. "Scrapie genetic susceptibility in Portuguese sheep breeds [6]". Veterinary Record 153 16 (2003): 508-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142211452&partnerID=MN8TOARS.
Preprint
  1. Nuno Sepúlveda; João Malato; Franziska Sotzny; Anna D Grabowska; André Fonseca; Clara Cordeiro; Luís Graça; et al. "Revisiting IgG antibody reactivity to Epstein-Barr virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and its potential application to disease diagnosis". 2022. https://doi.org/10.1101/2022.04.20.22273990.
    10.1101/2022.04.20.22273990
  2. André Fonseca; Przemyslaw Biecek; Clara Cordeiro; Nuno Sepúlveda. "Identification of immune responses predictive of clinical protection against Malaria using novel statistical pipelines". 2022. https://doi.org/10.1101/2022.10.06.22280719.
    10.1101/2022.10.06.22280719
  3. João Malato; Luís Graça; Nuno Sepúlveda. "Impact of imperfect diagnosis in ME/CFS association studies". 2022. https://doi.org/10.1101/2022.06.08.22276100.
    10.1101/2022.06.08.22276100
  4. Tiago Dias Domingues; Helena Mouriño; Nuno Sepúlveda. "Analysis of cutoff point estimation for determining seropositivity in the context of SARS-CoV-2 infections". 2021. https://doi.org/10.1101/2021.12.20.21268100.
    10.1101/2021.12.20.21268100
  5. Malato J; Sotzny F; Bauer S; Freitag H; Fonseca A; Grabowska AD; Graça L; et al. "The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies". 2021. http://europepmc.org/abstract/PPR/PPR302348.
    10.1101/2021.03.23.21254175
Thesis / Dissertation
  1. Sepúlveda, Nuno Henriques dos Santos de. "How is the T-cell repertoire shaped.". PhD, 2011. http://hdl.handle.net/10216/16139.

Other

Other output
  1. Statistical challenges of investigating a disease with a complex diagnosis. 2021. João Malato; Luís Graça; Luís Nacul; Eliana Lacerda; Nuno Sepúlveda. https://doi.org/10.1101/2021.03.19.21253905.
    10.1101/2021.03.19.21253905
  2. Analysis of antibody data using Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions. 2021. Tiago Dias Domingues; Helena Mouriño; Nuno Sepúlveda. https://doi.org/10.1101/2021.03.08.21252807.
    10.1101/2021.03.08.21252807
  3. Recommendations for Epidemiological Research in ME/CFS from the EUROMENE Epidemiology Working Group. 2020. Mudie K; Estévez-López F; Sekulic S; Ivanovs A; Sepulveda N; Zalewski P; Mengshoel AM; et al. http://europepmc.org/abstract/PPR/PPR220935.
    10.20944/preprints202009.0744.v1
  4. A Novel Multiplex qPCR Assay for Detection of Plasmodium falciparum with Histidine-rich Protein 2 and 3 (pfhrp2 and pfhrp3) Deletions in Polyclonal Infections. 2020. Grignard L; Nolder D; Sepúlveda N; Berhane A; Mihreteab S; Kaaya R; Phelan J; et al. http://europepmc.org/abstract/PPR/PPR111224.
    10.1101/2020.01.31.928986
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current Statistical methods for the analysis of multi-antibody data to inform malaria control and elimination strategies
Co-supervisor
 Medical Research Council (MRC) Translational and Quantitative Skills Doctoral Training Partnership (DTP) and CASE Studentship (PhD)
Lancaster University Centre for Health Informatics Computing and Statistics, United Kingdom
2022/01/01 - Current Análise conjunta da duração de internamento e mortalidade de pacientes portugueses utilizando base hospitalar de dados espaço-temporais
Co-supervisor
Universidade de Lisboa Instituto Superior Técnico Departamento de Matemática, Portugal
2020/01/01 - Current Regulatory T cells and their role on the aetiology of Myalgic encephalomyelitis/chronic fatigue syndrome
Supervisor
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2020/01/01 - Current Analysis of high-throughput antibody data for better understanding immunogenetics and epidemiology of malaria
Supervisor
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021/06 - 2022/10 Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
Supervisor
 Bioestatística (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/01 - 2022/09/30 Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
Supervisor
 Mestrado em Bioestatística (Master)
Universidade de Lisboa Departamento de Estatística e Investigação Operacional, Portugal
2018/10 - 2021/10/26 Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions applied to serological data
Supervisor
 Doutoramento em Estatística e Investigação Operacional (Especialidade de Bioestatística e Bioinformática) (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2020 Regulatory T cells and their role on the aetiology of Myalgic encephalomyelitis/chronic fatigue syndrome
Supervisor
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/01 - 2018/12 Statistical approaches to measure heterogeneity in malaria transmission intensity: An epidemiological study on the Tanzania populations
Supervisor
 Mestrado em Bioestatística (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2018 Bayesian analysis of incomplete data from malaria epidemiological studies investigating pfHRP2/pfHRP3 gene deletions
Supervisor
London School of Hygiene and Tropical Medicine Department of Medical Statistics, United Kingdom
2018 - 2018 Multivariate Serological Analysis of Malaria and Chronic Fatigue Syndrome
Supervisor
 Medical Statistics (Master)
London School of Hygiene and Tropical Medicine Department of Medical Statistics, United Kingdom
2017 - 2018 Quality of antenatal care services in Santiago, Cape Verde: a mixed methods analysis of structure and process barriers, from the healthcare professional’s perspective
Supervisor
 Public Health (Master)
London School of Hygiene and Tropical Medicine Faculty of Public Health and Policy, United Kingdom
2017 - 2017 Statistical Approaches to Analysing Serological Outcomes in Malaria Elimination Settings
Supervisor
 Medical Statistics (Master)
London School of Hygiene and Tropical Medicine Department of Medical Statistics, United Kingdom
2017 - 2017 Immune profiling of serological responses to Plasmodium falciparum using purified recombinant protein microarrays
Supervisor
 Medical Statistics (Master)
London School of Hygiene and Tropical Medicine Department of Medical Statistics, United Kingdom
2007 - 2009 Mapeamento Bayesiano para fenótipos binários complexos
Co-supervisor
 Estatística (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016 - 2016 Invited speaker
Workshop
 Genomic Epidemiology of Infectious Disease Workshop

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018/12 Statistical approaches to measure heterogeneity in malaria transmission intensity: An epidemiological study on the Tanzania populations
(Thesis) Arguer
 João Torrado Malato (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2010/01 - Current CEAUL - Centro de Estatística e Aplicações da Universidade de Lisboa
1999 - Current Sociedade Portuguesa de Estatística
2013 - 2019 London School of Hygiene & Tropical Medicine Malaria Centre

Committee member

Activity description
Role 		Institution / Organization
2018 - 2020 Managing committee of the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Member
 European Network on Myalgic Encephalomyelities/Chronic Fatigue Syndrome (EUROMENE), Latvia
2015 - 2019 Steering committee of the LSHTM Centre for Statistical Methodology
Member
 London School of Hygiene & Tropical Medicine Centre for Statistical Methodology, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/10/01 - Current Biostatistics (Master)
2013/10/01 - 2019/12/31 Analysis and Design of Research Studies (Master)
2007 - 2010 Bioestatística Fisioterapia (Licenciatura) Escola Superior de Saúde Egas Moniz, Portugal
2007 - 2010 Bioestatística Ciências da Nutrição (Licenciatura) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019/09 - Current PhD appraisal and upgrades in the Royal Veterinary College
Evaluator
 The Royal Veterinary College, United Kingdom

Journal scientific committee

Journal title (ISSN) Publisher
2020/05 - Current Frontiers in Medicine
2015 - Current Parasite Immunology
2010 - Current Proceedings of the National Academy of Sciences USA
Distinctions

Award

2011 MSD Award for Basic Research in Auto-Immunity
Sociedade Portuguesa de Medicina Interna - Núcleo de Estudos em Doenças Auto-imunes, Portugal
2008 Prémio SPE
Sociedade Portuguesa de Estatística, Portugal

Other distinction

2000 Melhor Poster do VIII Congresso da Sociedade Portuguesa de Estatística
Sociedade Portuguesa de Estatística, Portugal