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Soraia Silva graduated in Applied Biology in 2013 and completed a master’s in Molecular Genetics in 2016 at the University of Minho, Portugal. She participated with a research fellow (master's degree) in 2 projects funded by the Foundation for Science and Technology (FCT) at the University of Coimbra, Portugal. She is a Ph.D. student in Pharmaceutical Sciences with a scholarship from the FCT Doctoral Program "Research and Development of Drugs - Drugs R&D" since 2020. Over the last years, she published 11 articles in specialized and indexed international journals, along with various conference posters and oral communications. She is a Global Burden of Diseases (GBD) collaborator. She holds a contribution for a patent named "Intranasal administration for a sustained brain delivery of highly protein-bound drugs". She was rewarded with a British Society for Neuroendocrinology – research grant to carry out experiments in the Pathophysiological Molecular Clocks Lab at the University of Warwick, United Kingdom.
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Identification

Personal identification

Full name
Tânia Soraia Vieira da Silva

Citation names

  • Silva, Soraia

Author identifiers

Ciência ID
C11B-EF12-772B
ORCID iD
0000-0001-6726-5458

Addresses

  • Faculdade de Farmácia da Universidade de Coimbra. Pólo das Ciências da Saúde - Azinhaga de Santa Comba, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2020/05/01 - 2024/05/31
Ongoing
 Pharmaceutical Sciences - FCT Doctoral Program "Research and Development of Drugs - Drugs R&D" (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/05/21 - 2023/05/23
Concluded
 Introduction to Circadian Biology and Medicine (Outros)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/09/21 - 2022/09/23
Attended
 Summer School on Pharmaceutical Analysis (Outros)
Major in Curso não conferente de grau
Università degli Studi di Bologna - Campus di Rimini, Italy
2022/02/23 - 2022/02/24
Concluded
 Science Communication and Media Training Course (Outros)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2021/03/18 - 2021/03/20
Concluded
 Models of the Blood-Brain Barrier: Scientific Tools to Target the Brain (Outros)
Major in Curso não conferente de grau
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/07/08 - 2020/07/15
Concluded
 Regulatory affairs & Patents (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/06/01 - 2020/06/04
Concluded
 Pharmacometrics (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/05/08 - 2020/05/19
Concluded
 Trends in drug discovery (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/04/07 - 2020/05
Concluded
 New Frontiers in Drug Development (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/11/16 - 2020/01/24
Concluded
 XX Course on Determination of drugs by HPLC in biological samples (Outros)
Universidad de Salamanca Facultad de Farmacia, Spain
2018/11/24 - 2019/06/30
Concluded
 Laboratory Animal Sciences Course (Outros)
Major in Categoria B
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2018/03/12 - 2018/03/16
Concluded
 Advanced Course: Ageing - from cellular processes to the organism (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/01/08 - 2018/01/19
Concluded
 Course on Biostatistics (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2016
Concluded
 Molecular Genetics (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"The role of macroH2A1 in prostate carcinogenesis" (THESIS/DISSERTATION)
 17
2010 - 2013
Concluded
 Applied Biology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Study of the behavior of new fluorescent compounds with antitumor potential incorporated in nanoliposomes" (THESIS/DISSERTATION)
 15
Projects

Grant

Designation Funders
2020/05/01 - 2024/05/13 Chronopharmacokinetics and chronopharmacodynamics of intranasal antidepressants drugs
PD/BDE/150685/2020
PhD Student Fellow
Ongoing
2018/11/01 - 2020/04/30 N2BD - Desenvolvimento de uma nanoplataforma multifuncional Nose-to-Brain para o tratamento da Depressão e prevenção do desenvolvimento de fármaco-resistências
CENTRO-01-0145-FEDER-030752
Provided by PTCRIS: CENTRO-01-0145-FEDER-030752
Research Fellow
Associação para a Inovação e Desenvolvimento da FCT, Portugal
 Fundação para a Ciência e a Tecnologia
2016/06 - 2019/03 ARCADELIKE – desenvolvimento da arquitectura fisiológica do colagénio em cartilagem desenvolvida in-vitro por combinação de estímulo mecânico e scaffolds fibrosos anisótropicos em biorreator
Provided by PTCRIS: PTDC/EMS-TEC/3263/2014
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference paper
  1. Gonçalves, Joana; Silva, Soraia; Vitorino, Carla; Alves, Gilberto; Fortuna, Ana. "How does the device determine nose-to-brain drug delivery to mice?". Paper presented in Drug Delivery to the Lungs, Edimburgo, 2019.
  2. Vitorino, Carla; Silva, Soraia; Bicker, Joana; Carona, Andreia; Falcao, Amilcar; Fortuna, Ana. "Designing lipid nanoparticles for intranasal delivery of antidepressants". Paper presented in Drug Delivery to the Lungs, Edimburgo, 2019.
  3. Ferreira, Inês; Sousa, Cátia; Silva, Soraia; Judas, Fernando; Cavadas, Claudia; Mendes, Alexandrina Ferreira. "Expression and function of neuropeptide y receptors in human articular cartilage: influence of gender and osteoarthritis". Paper presented in EULAR congress, Amesterdão, 2018.
    10.1136/annrheumdis-2018-eular.6528
Conference poster
  1. Silva, Soraia; Fialho, Sara; Fortuna, Ana. Corresponding author: Fortuna, Ana. "Gender Differences During Unpredictable Chronic Mild Stress (UCMS) And Paroxetine Intranasal Administration To Mice". Paper presented in 36th ECNP Congress, 2023.
  2. Gonçalves, Joana; Silva, Soraia; Vitorino, Carla; Alves, Gilberto; Fortuna, Ana. "How does the device determine nose-to-brain drug delivery to mice?". Paper presented in Drug Delivery to the Lungs, 2019.
  3. Silva, Soraia; Vitorino, Carla; Gonçalves, Joana; Carona, Andreia; Bicker, Joana; Falcão, Amilcar; Fortuna, Ana; Falcão, Amílcar. "Application of in vitro nasal model for antidepressant drug permeation studies". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  4. Gonçalves, Joana; Silva, Soraia; Bicker, Joana; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Nose-to-brain delivery of levetiracetam: preclinical evidence". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  5. Brás, AR; Moreira, T; Silva, Soraia; Garcia, MH; Valente, A; Preto, A. "Multifunctional polymer-ruthenium conjugates: promising therapeutic approach to colorectal cancer". Paper presented in IV Symposium of the Doctoral Program on Molecular and Environmental Biology, 2018.
  6. Inês Ferreira; Cátia Sousa; Silva, Soraia; Fernando Judas; Cláudia Cavadas; Alexandrina Mendes. "Expression and function of neuropeptide y receptors in human articular cartilage: influence of gender and osteoarthritis". Paper presented in EULAR congress, 2018.
    10.1136/annrheumdis-2018-eular.6528
  7. Brás, AR; Moreira, T; Vieira-Silva, Tânia Soraia; Garcia, MH; Valente, A; Preto, A. "New ruthenium-based anticancer agents: a promising therapeutic approach to colorectal cancer". Paper presented in 3rd ASPIC International Congress, 2018.
  8. Brás, AR; Moreira, T; Vieira-Silva, Tânia Soraia; Garcia, MH; Valente, A; Preto, A. "New ruthenium-based anticancer agents: a promising therapeutic approach to colorectal cancer". Paper presented in 25th Cancer Meeting, 2018.
  9. Vieira-Silva, Tânia Soraia; Ramalho-Carvalho, João; Rodrigues, Â; Monteiro-Reis, Sara; Carneiro, Isa; Martins, A; Oliveira, Jorge; Henrique, Rui; Jerónimo, Carmen. "The value of macroH2A1 as biomarker for prostate cancer". Paper presented in OECI2015 - Oncology Days, 2015.
  10. Vieira-Silva, Tânia Soraia; Ramalho-Carvalho, João; Rodrigues, Â.; Monteiro-Reis, Sara; Carneiro, Isa; Martins, AT; Oliveira, J.; Henrique, R.; Jerónimo, Carmen. "The value of macroH2A1 as biomarker for prostate cancer". Paper presented in 19th Annual Meeting of the Portuguese Society of Human Genetics, 2015.
Journal article
  1. Guareschi, Fabiola; Fonseca, Carla; Silva, Soraia; Pescina, Silvia; Nicoli, Sara; Buttini, Francesca; Sonvico, Fabio; Fortuna, Ana. "Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation". European Journal of Pharmaceutical Sciences 205 (2025): 106994. https://doi.org/10.1016/j.ejps.2024.106994.
    10.1016/j.ejps.2024.106994
  2. Silva, Soraia; Bicker, Joana; Fialho, S.; Cunha, Susana; Falcão, Amílcar; Fortuna, Ana. "Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences". Biochemical Pharmacology 223 (2024): 116184. https://doi.org/10.1016/j.bcp.2024.116184.
    10.1016/j.bcp.2024.116184
  3. Silva, Soraia; Fonseca, Carla; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression". European Journal of Pharmaceutics and Biopharmaceutics 194 (2024): 118-130. http://dx.doi.org/10.1016/j.ejpb.2023.12.002.
    10.1016/j.ejpb.2023.12.002
  4. Henriques, Patrícia; Bicker, Joana; Silva, Soraia; Doktorovová, Slavomíra; Fortuna, Ana. "Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability". International Journal of Pharmaceutics 643 (2023): 123252. http://dx.doi.org/10.1016/j.ijpharm.2023.123252.
    10.1016/j.ijpharm.2023.123252
  5. Silva, Soraia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Air-liquid interface (ALI) impact on different respiratory cell cultures". European Journal of Pharmaceutics and Biopharmaceutics 184 (2023): 62-82. http://dx.doi.org/10.1016/j.ejpb.2023.01.013.
    10.1016/j.ejpb.2023.01.013
  6. Silva, Soraia; Bicker, Joana; Fonseca, Carla; Ferreira, Nuno R.; Vitorino, Carla; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation". Frontiers in Pharmacology 12 (2021): http://dx.doi.org/10.3389/fphar.2021.751321.
    10.3389/fphar.2021.751321
  7. Soraia Silva; Joana Bicker; Amílcar Falcão; Ana Fortuna. "Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13111975.
    10.3390/pharmaceutics13111975
  8. Gonçalves, Joana; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcão, Amílcar; Alves, Gilberto; Fortuna, Ana. "A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration". International Journal of Pharmaceutics 593 (2021): 120161. http://dx.doi.org/10.1016/j.ijpharm.2020.120161.
    10.1016/j.ijpharm.2020.120161
  9. Vitorino, Carla; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "QbD-driven development of intranasal lipid nanoparticles for depression treatment". European Journal of Pharmaceutics and Biopharmaceutics 153 (2020): 106-120. http://dx.doi.org/10.1016/j.ejpb.2020.04.011.
    10.1016/j.ejpb.2020.04.011
  10. Vitorino, Carla; Silva, Soraia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges". Drug Discovery Today 24 9 (2019): 1911-1923. http://dx.doi.org/10.1016/j.drudis.2019.06.001.
    10.1016/j.drudis.2019.06.001
  11. Vieira-Silva, Tânia Soraia; Monteiro-Reis, Sara; Barros-Silva, Daniela; Ramalho-Carvalho, João; Graça, Inês; Carneiro, Isa; Martins, Ana Teresa; et al. "Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype". Cancer Cell International 19 1 (2019): http://dx.doi.org/10.1186/s12935-019-0835-9.
    10.1186/s12935-019-0835-9
Thesis / Dissertation
  1. "The role of macroH2A1 in prostate carcinogenesis". Master, Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, 2015.

Intellectual property

Provisional application for patent
  1. 2022. "Intranasal administration for a sustained brain delivery of highly protein-bound drugs".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/30 Optimization of antidepressants for intranasal delivery. Talks about Research
University of Coimbra (Coimbra, Portugal)
2024/02/15 How to improve commercially available antidepressants? Neuroscience Cluster Seminar Series
University of Warwick (Conventry, United Kingdom)
2023/02/02 Dose-dependent pharmacokinetics of paroxetine after intranasal administration to mice. Portuguese Society of Pharmacology
Faculdade de Medicina, Universidade de Coimbra (Coimbra, Portugal)
2022/03/11 Chronopharmacokinetics and chronopharmacodynamics of intranasal antidepressant drugs. Three-minute Thesis Competition
Universidade de Coimbra Instituto de Investigação Interdiscipinar (Coimbra, Portugal)
2021/02/21 Intranasal co-administration of escitalopram and paroxetine in mice. SPF2021
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2020/02/06 Understanding nose-to-brain antidepressant delivery: a comprehensive in vitro/in vivo approach SPF2020
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/12/11 Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants. Drug Delivery to the Lungs
(Edinburgh, United Kingdom)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/10 - 2024/05 Pint of Science - Coimbra (2023/05/29 - 2023/05/31)
Other (Co-organisor)
2022/09/30 - 2022/09/30 European Researcher's Night 2022 (2022/09/30 - 2022/09/30)
Other (Other)
2020/02/05 - 2020/02/07 Sociedade Portuguesa de Farmacologia (2020/02/05 - 2020/02/07)
Meeting (Other)
2012/09/10 - 2013/03/01 XIV Jornadas de Biologia Aplicada (2013/02/27 - 2013/03/01)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/09/16 - 2022/09/16 Mostra Tecnológica Inovação em Saúde
Exhibition
 Inovação em Saúde
Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal

Universidade de Coimbra, Portugal
2018/09/28 - 2018/09/28 European Researchers' Night 2018

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/08 - 2022/08 Neuropsychiatric Disease and Treatment (1178-2021) Dove Medical Press Ltd
Distinctions

Award

2024 Invitation to New Researcher Network (NRN) Summer Event 2024 by NRN Committee from Drug Delivery to the Lungs, Viatris, United Kingdom.
2022 2nd place in the 3rd edition of Three-minute Thesis Competition
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Other distinction

2023 Visit Researcher by British Society for Neuroendocrinology