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Maria Manuel Cruz Silva completed the Doutoramento em Farmácia in 2005 by Universidade de Coimbra Faculdade de Farmácia, in collaboration with the CNR Milan, Italy. Before, she completed the Mestrado em Tecnologias do Medicamento in 1998 by Universidade de Coimbra Faculdade de Farmácia and Licenciatura em Ciências Farmacêuticas in 1995 by Universidade de Coimbra Faculdade de Farmácia. Maria Manuel Cruz Silva is Assistant Professor with tenure in the Universidade de Coimbra, Faculdade de Farmácia and Researcher in CNC.IBILI. As Assistant Professor in Faculdade de Farmácia she teaches several subjects in the area of Pharmaceutical Chemistry. Her scientific interests are in the area of Medicinal Chemistry, aiming at the rational design and synthesis of novel bioactive compounds. On 2019 integrated the Neuroendocrinology and Aging Group headed by Cláudia Cavadas, aiming at a more collaborative and interdisciplinary research in the interface of medicinal chemistry and neurobiology. Published 30 articles in scientific journals with referee, and three book chapters. Supervised and Co-supervises 4 PhD theses and 18 MSc dissertations. Participated as Researcher in 4 projects. In her professional activities interacted with 48 collaborators co-authorship of scientific papers.
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Identification

Personal identification

Full name
Maria Manuel Cruz Silva

Citation names

  • Silva, MMC

Author identifiers

Ciência ID
BE1E-9C1C-7D6C
ORCID iD
0000-0002-1938-4150

Telephones

Mobile phone
  • 934560401 (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Italian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2005
Concluded
 Doutoramento em Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Transformações Químio-enzimáticas em Esteróides" (THESIS/DISSERTATION)
 Aprovação com Distinção e Louvor
1998
Concluded
 Mestrado em Tecnologias do Medicamento (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Interacção do tamoxifeno e do hidroxitamoxifeno com eritrócitos humanos: mecanismos moleculares de acção hemolítica" (THESIS/DISSERTATION)
 Muito Bom
1995
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"sem título" (THESIS/DISSERTATION)
 Muito Bom
Affiliation

Science

Category
Host institution 		Employer
2012/01/01 - Current Researcher (Research) CNC.IBILI, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2005/06/14 - Current Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2023/05/01 - 2025/06/01 AMRFight - Exploring bacterial interactions to find novel molecules to combat the antimicrobial resistance catastrophe
2022.06809.PTDC
Co-Principal Investigator (Co-PI)
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2026/11/01 - 2027/11/01 REACT-FFI: (Re)shaping (A)pproaches for (C)ircadian Rhythm and gene (T)herapy in Familial Fatal Insomnia
15868 (MPr-2023-12)
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease
POCI-01-0145-FEDER-029369
Researcher
CNC.IBILI, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2020/06/30 Pequenas moléculas inibidoras do proteassoma: um passo em frente na descoberta de fármacos antitumorais
PTDC/QEQ-MED/7042/2014
Researcher
Universidade da Beira Interior, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2019/12/31 drugs2CAD/ Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos.
CENTRO-01-0247-FEDER-003269
Researcher
Universidade de Coimbra, Portugal
 Agência Nacional de Inovação SA
Concluded
2016/01/01 - 2019/12/31 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2015/12/31 Do espaço químico à função biológica: uma viagem pela mão da UC-NMR
RECI/QEQ-QFI/0168/2012
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2014/12/31 Towards malaria eradication. A novel approach for multitargeting the parasite’s life cycle
PTDC/SAU-FAR/118459/2010
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 177 - 2011-2012
PEst-OE/SAU/UI0177/2011
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Silva, MMC; Salvador, JAR. "Introductory Chapter: Chemistry and Biological Activity of Steroids - Scope and Overview". In Chemistry and Biological Activity of Steroids, edited by Salvador, JAR; Silva, MMC. United Kingdom: IntechOpen, 2020.
    Published • 10.5772/intechopen.88781
  2. Silva, MMC; Silvestre, Samuel; Jorge A. R. Salvador, Salvador, J.. "Recent Highlights in Green Oxidative Chemical Processes Applied to Steroid Chemistry". In Green Nanotechnology - Overview and Further Prospects. 2016.
    Published • 10.5772/62381
  3. Maria Manuel Cruz Silva; Samuel M. Silvestre; M. Manuel C. Silva; Jorge A.R. Salvador. "Recent Highlights in Green Oxidative Chemical Processes Applied to Steroid Chemistry". {InTech, 2016.
    10.5772/62381
  4. Silva, MMC; Sá e Melo, Maria Luisa; Carvalho, J.F.S.. "Cytotoxic Steroids and Derivatives: Exploring Natural Compounds to Develop Anticancer Drugs". In Steroids : biosynthesis, functions and health implications, edited by Carlos Amada Figueiredo; Luiza Cac¸a~o Garces. new york, United States: Nova Science Publishers, 2012.
Conference abstract
  1. Rodrigo F.N. Ribeiro; Andrea Magni; Pereira de Almeida, Luis ; Cavadas, Claudia; Giorgio Colombo; Silva, MMC. Corresponding author: Silva, MMC. "Development of novel sirtuin-1 activators: promising therapeutic tools against neurodegenerative diseases". Paper presented in GP2A 2024 – 32 nd Annual GP 2 A Medicinal Chemistry Conference, Coimbra, 2024.
  2. Rodrigo F.N. Ribeiro; Dina Pereira; Tiago Reis; Sara Lopes; Marisa Ferreira-Marques; Rita Fernandes; Leatitia S Gaspar; et al. "Investigating the Clock Components and Circadian Activity in the YAC-MJD Mouse Model". Paper presented in SPF Meeting 2023 - Reunião da Sociedade Portuguesa de Farmacologia, Farmacologia Clínica e de Toxicologia, Coimbra, 2023.
  3. Ribeiro, Rodrigo; Carmo-Silva, Sara; Álvaro, Ana Rita ; Cavadas, Claudia; Silva, MMC. "Searching for New Circadian Rhythm Regulators to Delay Aging". Paper presented in iMed Conference® 10.0 (AstraZeneca Foundation Innovate Competition), Lisbon, 2018.
Conference poster
  1. Rodrigo F.N. Ribeiro; Dina Pereira; Tiago Reis; Sara Lopes; Marisa Ferreira-Marques; Rita Fernandes; Laetitia S Gaspar; et al. "The Circadian Clock is Disrupted in the YAC Machado-Joseph Disease Mouse Model". Paper presented in BEB Day 2023 - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) 17th symposium, 2023.
  2. Silva, Ana Cristina Rosa da; Pereira, Marta; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER’S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021.
  3. Coimbra, Judite RM; Baptista, Salete J.; Silva, MMC; Dinis, Teresa; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Application of Computational Methods for Discovery of Novel BACE1 Hit Inhibitors: Ligand- and Structure-based Protocols with In Vitro Evaluation". Paper presented in the 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, 2020.
  4. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019.
  5. Rodrigo F.N. Ribeiro; Silva, MMC. "Improving the synthetic pathways to access age-promoting agents - Chemical and biocatalytic synthesis of oxysterols". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  6. Silva, Ana Cristina Rosa da; Pereira, Marta; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, MMC; et al. "Skin allergens and Alzheimer´s disease: preliminar studies on na (im)probable link". Paper presented in . 8th ECS workshop Calcium Signalin in Aging and Neurodegenerative Diseases, 2019.
  7. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Moreira, Patricia; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "Targeting Alzheimer´s Disease: A Virtual Screening Protocol to Discover New Central-Acting BACE1 Inhibitors". Paper presented in Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, 2019.
  8. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Moreira, Patricia; Silva, MMC; Dinis, Teresa; SALVADOR, J.A.R.. "Targeting Alzheimer´s Disease: An Integrated Protocol of Virtual Screening for Discovery of Novel Anti-BACE1 Agents". Paper presented in AD/PDTM 2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2019.
  9. Pereira, Marta; Silva, Ana Cristina Rosa da; Neves, Bruno; Moreira, Patricia; Silva, MMC; Santos, Armanda E; Pereira, Cláudia; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer´s disease". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  10. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "Identification of Novel BACE1 Inhibitors: A Combined Protocol of Pharmacophore Modeling, Virtual Screening and Structure-based Drug Design". Paper presented in XXV EFMC International Symposium on Medicinal Chemistry, 2018.
  11. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "New BACE I Inhibitors: A Structure-based and Ligand-based Rational Drug Design. Pharmacophore Modeling and Virtual Screening". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018.
Journal article
  1. Ribeiro, Rodrigo F. N.; Pereira, Dina; de Almeida, Luis Pereira; Silva, Maria Manuel C.; Cavadas, Cláudia. "SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders". Aging Clinical and Experimental Research 34 12 (2022): 2963-2976. http://dx.doi.org/10.1007/s40520-022-02257-y.
    Published • 10.1007/s40520-022-02257-y
  2. Pedro H.O. Borges; Sónia Pedreiro; Salete J. Baptista; Carlos F.G.C. Geraldes; M.T. Batista; Maria M.C. Silva; Artur Figueirinha. "Inhibition of a-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf". Journal of Ethnopharmacology 280 (2021): 114470-114470. https://doi.org/10.1016/j.jep.2021.114470.
    10.1016/j.jep.2021.114470
  3. Cavadas, Cláudia; Ribeiro, Rodrigo F.N.; Silva, MMC. "Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases". Drug Discovery Today 26 7 (2021): 1620-1641. https://doi.org/10.1016/j.drudis.2021.03.015.
    Published • 10.1016/j.drudis.2021.03.015
  4. Silva, MMC. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences 21 20 (2020): 7791-7791. http://dx.doi.org/10.3390/ijms21207791.
    10.3390/ijms21207791
  5. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    Published • 10.3390/biom10040535
  6. Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach". PLOS ONE 12 1 (2017): e0170846. http://dx.doi.org/10.1371/journal.pone.0170846.
    Published • 10.1371/journal.pone.0170846
  7. Kasal, Alexander; Budešínský, Miloš; Mareš, Pavel; Krištofíková, Zdena; Leitão, Alcino J.; Melo, Maria Luisa Sá e; Silva, Maria Manuel C.. "Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?". Steroids 105 (2016): 12-18. http://dx.doi.org/10.1016/j.steroids.2015.11.007.
    Published • 10.1016/j.steroids.2015.11.007
  8. Sá e Melo, Maria Luisa; Cruz Silva, Maria Manuel; Iuliano, Luigi; Lizard, Gérard. "Oxysterols and related sterols: Chemical, biochemical and biological aspects". Steroids 99 (2015): 117-118. http://dx.doi.org/10.1016/j.steroids.2015.05.006.
    Published • 10.1016/j.steroids.2015.05.006
  9. Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L.. "Anticancer steroids: Linking natural and semi-synthetic compounds". Natural Product Reports 30 2 (2013): 324-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS.
    Published • 10.1039/c2np20082a
  10. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Carvalho, J.F.S.; Cruz Silva, M.M.. "5a,6a-Epoxy-7-norcholestan-3ß-yl acetate". Acta Crystallographica Section E: Structure Reports Online 68 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855383781&partnerID=MN8TOARS.
    Published • 10.1107/S1600536811054249
  11. Silva, MMC. "Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.". Journal of Medicinal Chemistry (2011): http://pubs.acs.org/doi/pdf/10.1021/jm200803d.
    10.1021/jm200803d.
  12. Silva, M.M.C.; Carvalho, J.F.; Riva, S.; Sá e Melo, M.L.. "Biocatalytic transformations of steroids: Focus on hydrolase-catalyzed reactions". Current Organic Chemistry 15 6 (2011): 928-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051807267&partnerID=MN8TOARS.
    Published • 10.2174/138527211794518871
  13. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR". Journal of Medicinal Chemistry 54 18 (2011): 6375-6393. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052798129&partnerID=MN8TOARS.
    Published • 10.1021/jm200803d
  14. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Sterols as anticancer agents: Synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis". Journal of Medicinal Chemistry 53 21 (2010): 7632-7638. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149265180&partnerID=MN8TOARS.
    Published • 10.1021/jm1007769
  15. Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L.. "Efficient trans-diaxial hydroxylation of ¿5-steroids". Tetrahedron 66 13 (2010): 2455-2462. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349102219&partnerID=MN8TOARS.
    10.1016/j.tet.2010.01.089
  16. Carvalho, J.F.S.; Cruz Silva, M.M.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols". Journal of Medicinal Chemistry 52 13 (2009): 4007-4019. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649968077&partnerID=MN8TOARS.
    Published • 10.1021/jm9003973
  17. Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L.. "Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate". Tetrahedron 65 14 (2009): 2773-2781. http://www.scopus.com/inward/record.url?eid=2-s2.0-60949095554&partnerID=MN8TOARS.
    Published • 10.1016/j.tet.2009.01.100
  18. Monti, D.; Candido, A.; Cruz Silva, M.M.; Kren, V.; Riva, S.; Danieli, B.. "Biocatalyzed generation of molecular diversity: Selective modification of the saponin asiaticoside". Advanced Synthesis and Catalysis 347 7-8 (2005): 1168-1174. http://www.scopus.com/inward/record.url?eid=2-s2.0-20544436676&partnerID=MN8TOARS.
    Published • 10.1002/adsc.200505047
  19. Cruz Silva, M.M.; Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.; Sá E Melo, M.L.. "Cyanosilylation at pregnane side-chains: Selective synthesis and crystal structure of 20(R)-silylated cyanohydrins". Steroids 70 3 (2005): 145-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844315734&partnerID=MN8TOARS.
    Published • 10.1016/j.steroids.2004.10.011
  20. Silva, M.M.C.; Riva, S.; Sá E Melo, M.L.. "Regioselective enzymatic acylation of vicinal diols of steroids". Tetrahedron 61 12 (2005): 3065-3073. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644432451&partnerID=MN8TOARS.
    Published • 10.1016/j.tet.2005.01.104
  21. Cruz Silva, M.M.; Riva, S.; Sá E Melo, M.L.. "Highly selective lipase-mediated discrimination of diastereomeric 5,6-epoxysteroids". Tetrahedron Asymmetry 15 7 (2004): 1173-1179. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642634574&partnerID=MN8TOARS.
    Published • 10.1016/j.tetasy.2004.02.010
  22. Cruz Silva, M.M.; Sá E Melo, M.L.; Parolin, M.; Tessaro, D.; Riva, S.; Danieli, B.. "The biocatalyzed stereoselective preparation of polycyclic cyanohydrins". Tetrahedron Asymmetry 15 1 (2004): 21-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787843&partnerID=MN8TOARS.
    Published • 10.1016/j.tetasy.2003.11.003
  23. Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A.. "Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis". Toxicology in Vitro 15 6 (2001): 615-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034754864&partnerID=MN8TOARS.
    Published • 10.1016/S0887-2333(01)00079-0
  24. Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A.. "Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure". Biochimica et Biophysica Acta - Biomembranes 1464 1 (2000): 49-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033966237&partnerID=MN8TOARS.
    Published • 10.1016/S0005-2736(99)00237-0
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/05/18 Cholesterol Metabolism and Cancer. Endogenous and synthetic oxysterols with selective cytotoxicity. BIT's 11th Annual World Cancer Congress 2018, Philadelphia
BIT Congress Inc (Philadelphia, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01/01 - 2025/12/31 Fine tuning circadian rhythm as an innovative approach against Machado-Joseph Disease
Supervisor
 Doutoramento em Ciências Farmacêuticas, especialidade Química Farmacêutica (PhD)
2024/09/01 - 2025/07/31 Sirtuin-1 allosteric activators: exploring selectivity to reduce off-target effects
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2024/09/01 - 2025/07/31 Design e Síntese de novos derivados esteróides com potencial antimalárico
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2023/09/01 - 2025/02/28 Compostos canabinóides com interesse farmacológico: relações estrutura-atividade e oportunidades de otimização semissintética
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2023/09/01 - 2025/02/23 Caracterização Físico-Química de Matérias-Primas Envolvidas na Produção de Comprimidos por Compressão Direta e Desenvolvimento Galénico para Otimização do Processo
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2019/09/01 - 2022/09/09 Modulating the circadian rhythm through nuclear receptors ligands. A rational drug discovery approach
Supervisor
 Programa Doutoral em Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/01 - 2021/06/29 Genetic determinants of malaria therapeutics' cross resistance with novel compounds
Co-supervisor
 PhD in Ageing and Chronic Disease (PhD)
Universidade do Minho, Portugal

Universidade de Coimbra, Portugal

Universidade Nova de Lisboa, Portugal
2017/09/01 - 2018/09/30 Síntese químio-enzimática de novos derivados de flavonóides com actividade anti-inflamatória
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/01 - 2018/09/30 Estudo de reacções de acilação regiosselectiva da polidatina sob catálise enzimática.
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/01 - 2018/09/18 Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2017/09/01 - 2018/09/16 Inibição Da ¿lfa-Glucosidase Por Flavonóides do Cymbopogon citratus - Estudos in silico e in vitro
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2017/09/01 - 2018/09/15 Estudo das reações de acilação regiosseletiva da polidatina sob catálise enzimática
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2017/09/01 - 2018/09/05 Síntese de derivados do estradiol com potencial atividade neuroprotetora
Co-supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra, Portugal
2017/09/01 - 2018/09/04 Inibição Da ¿lfa-Glucosidase Por Flavonóides do Cymbopogon citratus - Estudos in silico e in vitro
Supervisor
 ´Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/01/01 - 2018/06/12 Rational design, synthesis and evaluation of novel anticancer chemopotentiators acting on DNA-repair pathways.
Co-supervisor of Maria de La Salete de Jesus Baptista
 Doutoramento em Farmácia, especialidade em Química Farmacêutica (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/01 - 2017/02/05 Preparation of new bioactive flavonoid derivatives
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/01 - 2017/01/15 Computational studies for the discovery of novel inhibitors of metallo beta-lactamases as therapeutic targets for antibiotic resistance
Supervisor
 Mestrado em Design e Desenvolvimento de Fármacos (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/01 - 2016/09/05 Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratório
Supervisor
 Mestrado em Biotecnologia Farmacêutica (Degree)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/02 - 2016/09/04 Preparação e avaliação da actividade anti-inflamatória de novos derivados polifenólicos glicosilados
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/02 - 2016/09/02 Steroidal endoperoxides in the synthesis of novel antimalarial hybrids
Supervisor
 Mestrado em Design e Desenvolvimento de Fármacos (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/09/04 - 2015/03/03 Semi-síntese de novos derivados flavonóides bioactivos. Estudo de reacções de acilação regiosseletiva da rutina sob catálise enzimática
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/09/01 - 2013/02/01 Semi-síntese de novos derivados flavonóides bioactivos. Estudo de reacções de acilação e desacilação regiosseletivas recorrendo a lipases como catalisadores.
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/09/01 - 2012/10/01 Modificações estruturais de compostos polifenólicos glicosilados e modulação das suas actividades antioxidantes.
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
Distinctions

Award

2018 AstraZeneca Innovate Competition - iMed Conference 10.0
AstraZeneca Produtos Farmacêuticos Lda, Portugal