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Maria Manuel Cruz Silva completed the Doutoramento em Farmácia in 2005 by Universidade de Coimbra Faculdade de Farmácia, in collaboration with the CNR Milan, Italy. Before, she completed the Mestrado em Tecnologias do Medicamento in 1998 by Universidade de Coimbra Faculdade de Farmácia and Licenciatura em Ciências Farmacêuticas in 1995 by Universidade de Coimbra Faculdade de Farmácia. Maria Manuel Cruz Silva is co-founder of the start-up Chem4Pharma, funded on 2015 by the Agência Nacional de Inovação in a project titled Drugs2CAD. Maria Manuel Cruz Silva is Assistant Professor with tenure in the Universidade de Coimbra, Faculdade de Farmácia and Researcher in CNC.IBILI. As Assistant Professor in Faculdade de Farmácia she teaches several subjects in the area of Pharmaceutical Chemistry. Her scientific interests are in the area of Medicinal Chemistry, aiming at the rational design and synthesis of novel bioactive compounds. On 2019 integrated the Neuroendocrinology and Aging Group headed by Cláudia Cavadas, aiming at a more collaborative and interdisciplinary research in the interface of medicinal chemistry and neurobiology. Published 23 articles in scientific journals with referee, and three book chapters. Supervises and Co-supervises 4 PhD theses and 11 MSc dissertations. Participated as Researcher in 4 projects. In her professional activities interacted with 48 collaborators co-authorship of scientific papers.
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Identification

Personal identification

Full name
Maria Manuel Cruz Silva

Citation names

  • Silva, MMC

Author identifiers

Ciência ID
BE1E-9C1C-7D6C
ORCID iD
0000-0002-1938-4150

Telephones

Mobile phone
  • 934560401 (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Italian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2005
Concluded
 Doutoramento em Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Transformações Químio-enzimáticas em Esteróides" (THESIS/DISSERTATION)
 Aprovação com Distinção e Louvor
1998
Concluded
 Mestrado em Tecnologias do Medicamento (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Interacção do tamoxifeno e do hidroxitamoxifeno com eritrócitos humanos: mecanismos moleculares de acção hemolítica" (THESIS/DISSERTATION)
 Muito Bom
1995
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"sem título" (THESIS/DISSERTATION)
 Muito Bom
Affiliation

Science

Category
Host institution 		Employer
2012/01/01 - Current Researcher (Research) CNC.IBILI, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2005/06/14 - Current Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2023/05/01 - 2025/06/01 AMRFight - Exploring bacterial interactions to find novel molecules to combat the antimicrobial resistance catastrophe
2022.06809.PTDC
Co-Principal Investigator (Co-PI)
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2018/07/01 - 2021/06/30 Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease
POCI-01-0145-FEDER-029369
Researcher
CNC.IBILI, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/04/01 - 2019/12/31 drugs2CAD/ Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos.
CENTRO-01-0247-FEDER-003269
Researcher
Universidade de Coimbra, Portugal
 Agência Nacional de Inovação SA
Concluded
2016/01/01 - 2019/12/31 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2014/12/31 Towards malaria eradication. A novel approach for multitargeting the parasite’s life cycle
PTDC/SAU-FAR/118459/2010
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Silva, MMC; Salvador, JAR. "Introductory Chapter: Chemistry and Biological Activity of Steroids - Scope and Overview". In Chemistry and Biological Activity of Steroids, edited by Salvador, JAR; Silva, MMC. United Kingdom: IntechOpen, 2020.
    Published • 10.5772/intechopen.88781
  2. Silva, MMC. "Recent Highlights in Green Oxidative Chemical Processes Applied to Steroid Chemistry". In Green Nanotechnology - Overview and Further Prospects. 2016.
  3. Silva, MMC; Sá e Melo, Maria Luisa; Carvalho, J.F.S.. "Cytotoxic Steroids and Derivatives: Exploring Natural Compounds to Develop Anticancer Drugs". In Steroids : biosynthesis, functions and health implications, edited by Carlos Amada Figueiredo; Luiza Cac¸a~o Garces. new york, United States: Nova Science Publishers, 2012.
Journal article
  1. Ribeiro, Rodrigo F. N.; Pereira, Dina; de Almeida, Luis Pereira; Silva, Maria Manuel C.; Cavadas, Cláudia. "SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders". Aging Clinical and Experimental Research 34 12 (2022): 2963-2976. http://dx.doi.org/10.1007/s40520-022-02257-y.
    Published • 10.1007/s40520-022-02257-y
  2. Pedro H.O. Borges; Sónia Pedreiro; Salete J. Baptista; Carlos F.G.C. Geraldes; M.T. Batista; Maria M.C. Silva; Artur Figueirinha. "Inhibition of a-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf". Journal of Ethnopharmacology 280 (2021): 114470-114470. https://doi.org/10.1016/j.jep.2021.114470.
    10.1016/j.jep.2021.114470
  3. "Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases". Drug Discovery Today (2021):
    10.1016/j.drudis.2021.03.015
  4. Silva, MMC. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences 21 20 (2020): 7791-7791. http://dx.doi.org/10.3390/ijms21207791.
    10.3390/ijms21207791
  5. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    Published • 10.3390/biom10040535
  6. Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach". PLOS ONE 12 1 (2017): e0170846. http://dx.doi.org/10.1371/journal.pone.0170846.
    Published • 10.1371/journal.pone.0170846
  7. Kasal, Alexander; Budešínský, Miloš; Mareš, Pavel; Krištofíková, Zdena; Leitão, Alcino J.; Melo, Maria Luisa Sá e; Silva, Maria Manuel C.. "Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?". Steroids 105 (2016): 12-18. http://dx.doi.org/10.1016/j.steroids.2015.11.007.
    Published • 10.1016/j.steroids.2015.11.007
  8. Sá e Melo, Maria Luisa; Cruz Silva, Maria Manuel; Iuliano, Luigi; Lizard, Gérard. "Oxysterols and related sterols: Chemical, biochemical and biological aspects". Steroids 99 (2015): 117-118. http://dx.doi.org/10.1016/j.steroids.2015.05.006.
    Published • 10.1016/j.steroids.2015.05.006
  9. Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L.. "Anticancer steroids: Linking natural and semi-synthetic compounds". Natural Product Reports 30 2 (2013): 324-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS.
    Published • 10.1039/c2np20082a
  10. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Carvalho, J.F.S.; Cruz Silva, M.M.. "5a,6a-Epoxy-7-norcholestan-3ß-yl acetate". Acta Crystallographica Section E: Structure Reports Online 68 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855383781&partnerID=MN8TOARS.
    Published • 10.1107/S1600536811054249
  11. Silva, MMC. "Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.". Journal of Medicinal Chemistry (2011): http://pubs.acs.org/doi/pdf/10.1021/jm200803d.
    10.1021/jm200803d.
  12. Silva, M.M.C.; Carvalho, J.F.; Riva, S.; Sá e Melo, M.L.. "Biocatalytic transformations of steroids: Focus on hydrolase-catalyzed reactions". Current Organic Chemistry 15 6 (2011): 928-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051807267&partnerID=MN8TOARS.
    Published • 10.2174/138527211794518871
  13. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR". Journal of Medicinal Chemistry 54 18 (2011): 6375-6393. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052798129&partnerID=MN8TOARS.
    Published • 10.1021/jm200803d
  14. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Sterols as anticancer agents: Synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis". Journal of Medicinal Chemistry 53 21 (2010): 7632-7638. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149265180&partnerID=MN8TOARS.
    Published • 10.1021/jm1007769
  15. Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L.. "Efficient trans-diaxial hydroxylation of ¿5-steroids". Tetrahedron 66 13 (2010): 2455-2462. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349102219&partnerID=MN8TOARS.
    10.1016/j.tet.2010.01.089
  16. Carvalho, J.F.S.; Cruz Silva, M.M.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L.. "Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols". Journal of Medicinal Chemistry 52 13 (2009): 4007-4019. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649968077&partnerID=MN8TOARS.
    Published • 10.1021/jm9003973
  17. Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L.. "Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate". Tetrahedron 65 14 (2009): 2773-2781. http://www.scopus.com/inward/record.url?eid=2-s2.0-60949095554&partnerID=MN8TOARS.
    Published • 10.1016/j.tet.2009.01.100
  18. Monti, D.; Candido, A.; Cruz Silva, M.M.; Kren, V.; Riva, S.; Danieli, B.. "Biocatalyzed generation of molecular diversity: Selective modification of the saponin asiaticoside". Advanced Synthesis and Catalysis 347 7-8 (2005): 1168-1174. http://www.scopus.com/inward/record.url?eid=2-s2.0-20544436676&partnerID=MN8TOARS.
    Published • 10.1002/adsc.200505047
  19. Cruz Silva, M.M.; Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.; Sá E Melo, M.L.. "Cyanosilylation at pregnane side-chains: Selective synthesis and crystal structure of 20(R)-silylated cyanohydrins". Steroids 70 3 (2005): 145-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844315734&partnerID=MN8TOARS.
    Published • 10.1016/j.steroids.2004.10.011
  20. Silva, M.M.C.; Riva, S.; Sá E Melo, M.L.. "Regioselective enzymatic acylation of vicinal diols of steroids". Tetrahedron 61 12 (2005): 3065-3073. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644432451&partnerID=MN8TOARS.
    Published • 10.1016/j.tet.2005.01.104
  21. Cruz Silva, M.M.; Riva, S.; Sá E Melo, M.L.. "Highly selective lipase-mediated discrimination of diastereomeric 5,6-epoxysteroids". Tetrahedron Asymmetry 15 7 (2004): 1173-1179. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642634574&partnerID=MN8TOARS.
    Published • 10.1016/j.tetasy.2004.02.010
  22. Cruz Silva, M.M.; Sá E Melo, M.L.; Parolin, M.; Tessaro, D.; Riva, S.; Danieli, B.. "The biocatalyzed stereoselective preparation of polycyclic cyanohydrins". Tetrahedron Asymmetry 15 1 (2004): 21-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787843&partnerID=MN8TOARS.
    Published • 10.1016/j.tetasy.2003.11.003
  23. Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A.. "Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis". Toxicology in Vitro 15 6 (2001): 615-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034754864&partnerID=MN8TOARS.
    Published • 10.1016/S0887-2333(01)00079-0
  24. Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A.. "Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure". Biochimica et Biophysica Acta - Biomembranes 1464 1 (2000): 49-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033966237&partnerID=MN8TOARS.
    Published • 10.1016/S0005-2736(99)00237-0
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/05/18 Cholesterol Metabolism and Cancer. Endogenous and synthetic oxysterols with selective cytotoxicity. BIT's 11th Annual World Cancer Congress 2018, Philadelphia
BIT Congress Inc (Philadelphia, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09/01 - 2022/09/09 Modulating the circadian rhythm through nuclear receptors ligands. A rational drug discovery approach
Supervisor
 Programa Doutoral em Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/01 - 2021/06/29 Genetic determinants of malaria therapeutics' cross resistance with novel compounds
Co-supervisor
 PhD in Ageing and Chronic Disease (PhD)
Universidade do Minho, Portugal

Universidade de Coimbra, Portugal

Universidade Nova de Lisboa, Portugal
2017/09/01 - 2018/09/30 Síntese químio-enzimática de novos derivados de flavonóides com actividade anti-inflamatória
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/01 - 2018/09/30 Estudo de reacções de acilação regiosselectiva da polidatina sob catálise enzimática.
Supervisor
 Mestrado em Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/01/01 - 2018/06/12 Rational design, synthesis and evaluation of novel anticancer chemopotentiators acting on DNA-repair pathways.
Co-supervisor
 Doutoramento em Farmácia, especialidade em Química Farmacêutica (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
Distinctions

Award

2018 AstraZeneca Innovate Competition - iMed Conference 10.0
AstraZeneca Produtos Farmacêuticos Lda, Portugal