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Cláudia Silva holds a BSc in Biochemistry (2013) from the CESPU and an MSc in Applied Biochemistry (2015) from the University of Minho. In 2022, she obtained her PhD in Metabolism - Clinical and Experimental from the Faculty of Medicine of the University of Porto (FMUP). Currently, she is a postdoctoral researcher at LAQV/REQUIMTE. She has developed research work in the study of diseases (e.g. cancer, diabetes, obesity) pathophysiology, and the molecular and cellular mechanisms involved in the cellular uptake of nutrients, especially glucose and glutamine and how these mechanisms interfere with these pathologies. More recently, the use of waste, food industry by-products rich in bioactive compounds such as polyphenols with potential in the context of obesity, diabetes, and cancer, has also been his focus of interest. She has proven experience in different approaches such as, in vitro models (cell lines), in vivo models (animal models), in manipulation and processing of biological samples (tissues, cells, plasma, urine, stool and gastric juice), analysis of clinical databases and integration and interpretation of the obtained data using bioinformatics tools. Since the beginning of her research career, she published 28 ISI original papers and 1 book chapter. She has also presented her work at more than 50 national and international scientific meetings. Cláudia participated in BSc and MSc juries, contributed as a referee for international ISI-indexed journals and was a member of the organizing committee of scientific events. In addition, she has been responsible for co-supervising postgraduate and undergraduate students. She is an Invited Assistant Professor at FMUP, where she teaches Human Metabolism to the Medicine MSc. Additionally, she also is an invited lecturer in the Master's and Doctoral programs in Metabolism (FMUP). Cláudia operates in the areas of Biological Sciences (Biochemistry, Cell Biology, Molecular Biology, Reproductive Biology and Microbiology), Health Sciences (Pharmacology, Toxicology, Nutrition, Dietetics, Oncology, Endocrinology and Metabolism) and food biotechnology.
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Identification

Personal identification

Full name
Cláudia Raquel Santos Silva
Date of birth
1991/06/21
Gender
Female

Citation names

  • Silva, Cláudia

Author identifiers

Ciência ID
BE11-06B1-2EEE
ORCID iD
0000-0003-2937-974X
AuthenticusID
R-00K-HYK
Scopus Author Id
36475670400

Email addresses

  • claudiasilva@med.up.pt (Professional)

Telephones

Telephone
  • 220426829 Ext.: 26829 (Professional)

Addresses

  • Al. Prof. Hernâni Monteiro, 4200-319, 501413197, Porto, Porto, Portugal (Professional)

Websites

  • https://www.linkedin.com/in/cláudia-silva-56a568109/ (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Natural sciences - Biological Sciences - Reproductive Biology
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
  • Natural sciences - Biological Sciences - Plant sciences
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
  • Agrarian Sciences - Agrarian and Food Biotechnology - Agricultural Biotechnology and Food Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/12 - 2022/04/12
Concluded
 Metabolism: Clinical and Experimental (Doutoramento)
Major in Metabolism
Universidade do Porto Faculdade de Medicina, Portugal
"The role of nutrient transport by cancer cells in the interaction between type 2 diabetes and breast cancer" (THESIS/DISSERTATION)
 Approved
2021/07/05 - 2021/07/09
Concluded
 Workshop Organoids systems for the study of infection (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2020/09/07 - 2020/09/18
Concluded
 Laboratory Animal Science Course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2020/01/28
Concluded
 Clinical Investigator Certification - Level 1 (Outros)
Major in Ensaios Clínicos
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Aveiro, Portugal
77%
2019/05/13 - 2019/05/16
Concluded
 IX Workshop on Cancer Research: Biological and Molecular Basis (Outros)
Major in Cancer Biology
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2019/02/11 - 2019/02/15
Concluded
 Gene and Cell-Based Advanced Therapies (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
 Approved
2013/09 - 2015/12
Concluded
 Applied Biochemistry (Mestrado)
Major in Biomedicine
Universidade do Minho Escola de Ciências, Portugal
"O efeito da insulina na placentação: estudos in vitro com células HTR8/SVneo" (THESIS/DISSERTATION)
 16
2009/09 - 2013/02
Concluded
 Biochemistry (Licenciatura)
Major in Biochemistry
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
"Relação entre as proteínas do checkpoint mitótico e a proteína Splindly durante a ligação dos cromossomas mitóticos aos microtúbulos" (THESIS/DISSERTATION)
 12
Affiliation

Science

Category
Host institution 		Employer
2023/07/01 - Current Postdoc (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2022/11/01 - 2023/06/30 Contracted Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2016/01 - 2018/10 Researcher (Research) Bepharbel, Belgium
Universidade do Porto Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2018/06 - 2024/08/31 Lecturer (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2018/07 - 2024/07 Monitor of Project International Federation Medical Students Associations Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2015/09 - 2023/09 Monitor of Universidade Júnior: Escola de Ciências da Vida e da Saúde Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2023/04/20 - 2023/04/23 Mostra University of Porto - Volunteering Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2018/11/01 - 2021/12/31 PhD student with NORTE2020 grant NORTE-08-5369-FSE-000018 Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/01 - 2020/09/30 Health technician - volunteering COVID 19 Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2014/09 - 2015/12 Trainee at the Metabesity group (MSc) Universidade do Minho Escola de Ciências, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2012/01 - 2012/07 Trainee at the Mitosis & Cancer Biology group (BCs) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Projects

Grant

Designation Funders
2023/07/01 - Current COBY4HEALTH ¿ Can coffee by-products decrease the risk of metabolic syndrome? A comprehensive approach to reduce waste and valorize health benefits
PTDC/SAU-NUT/2165/2021
Post-doc Fellow
Universidade do Porto Faculdade de Farmácia, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018/11 - 2021/12 The role of nutrient transport by cancer cells in the interaction between type 2 diabetes mellitus and breast cancer
NORTE-08-5369-FSE-000018
PhD Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Concluded

Contract

Designation Funders
2022/11/01 - 2023/06/30 IMAGE ¿ Individualized gastric adenocarcinoma early diagnosis and improved patients¿ survival: from liquid biopsies to a comprehensive management approach
NORTE-01-0145-FEDER-000050
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Concluded

Other

Designation Funders
2016/01 - 2018/10 Anticarcinogenic effect of Catequin.Lys complex in breast cancer, pancreatic and colon cell lines: investigation of its effect in cellular nutrient uptake
BePharBel
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Silva, Cláudia; Martel, Fátima. "Nutrient Transporters: New Molecular Targets for Triple Negative Breast Cancer in Type 2 Diabetics". In Interdisciplinary Cancer Research. Springer International Publishing, 2022.
    Accepted • 10.1007/16833_2022_95
Conference abstract
  1. Demissie Shimelis Gebiba; Ramachandran Venkatesha Perumal; Legesse Adane Bahiru; Rita C. Alves; Anabela S.G. Costa; Nelson Andrade; Silva, Cláudia; Fátima Martel; M. Beatriz P.P. Oliveira. "Antioxidant, anti-inflammatory, anti-diabetic, and cytotoxic potential of ethanolic leaf extracts from Englerina woodfordiodes M. Gilbert and Oncocalyx fischeri (Ebgl.) M. Gilbert". Paper presented in The 5th International Electronic Conference on Foods (Foods 2024), 2025.
Conference poster
  1. Diana Martins; Ana Beatriz Batista; Javier Centralles Lodeiro ; Sílvia O. Diaz; Juliana Ferreira; Silva, Cláudia; António Carlos Ferreira; et al. "Gut microbiome in stroke patients: potential implications in functional outcomes". Paper presented in 3rd International Meeting of the Portuguese Society of Physiology, 2024.
  2. Diana Martins; Ana Beatriz Batista; Javier Centralles Lodeiro ; Sílvia O. Diaz; Juliana Ferreira; Silva, Cláudia; António Carlos Ferreira; et al. "Impact of gut microbiome on functional recovery in stroke patients". Paper presented in 2nd Conference of the Doctoral Program in Metabolism – Clinical and Experimental (MET-CONF 2024), 2024.
  3. Sara Pinto; Francisca Carmo; Silva, Cláudia; Nelson Andrade; Fátima Martel. "Effect of dietary carotenoids and polyphenols on pancreatic cancer cell metabolism". Paper presented in 2nd Conference of the Doctoral Program in Metabolism – Clinical and Experimental (MET-CONF 2024), 2024.
  4. André Cristovão; Nelson Andrade; Fátima Martel; Silva, Cláudia. "Effect of gliflozins in combination with metformin on pancreatic cancer cell lines". Paper presented in 2nd Conference of the Doctoral Program in Metabolism – Clinical and Experimental (MET-CONF 2024), 2024.
  5. Isabel M. Miranda; Sara Vieira-Silva; Javier Centelles-Lodeiro; Catarina Lopes; Diogo Libânio; António Carlos Ferreira; Silva, Cláudia; et al. "Microbial markers in gastric cancer: exploring gastric microbiota for prognostic insights and early detection". Paper presented in Digestive Disease Week 2024, 2024.
  6. Faezeh Fathi; Anabela S. G. Costa; Nelson Andrade; Silva, Cláudia; Fátima Martel; Rita C. Alves; M. Beatriz P. P. Oliveira. "Antitumoral Activity of Gunnera tinctoria Extracts on a Pancreatic cell line". Paper presented in XXVI Encuentro Galego - Portuguese of Chemistry, 2022.
  7. Antunes, Ana; Carmo, Francisca; Andrade, Nelson; Silva, Cláudia; Martel, Fátima. "Effect of carotenoids on nutrient uptake by MDA-MB-231 cells". Paper presented in IJUP 2022, 15º Encontro Investigação Jovem, 2022.
  8. Carmo, Francisca; Silva, Cláudia; Martel, Fátima. "Inhibition of glutamine cellular uptake by xanthohumol results in a cytotoxic effect in MDA-MB-231 cells". Paper presented in IJUP 2022, 15º Encontro Investigação Jovem, 2022.
  9. Nelson Andrade; Liliana Espírito Santo; Juliana A. Barreto Peixoto; Cláudia Silva; Rita C. Alves; M. Beatriz P. P. Oliveira; Fátima Martel. "Opuntia Ficus-Indica (L.) Miller Cladores: Effect on different types of cancer cell lines". Paper presented in ESEKI Food Association, 2021.
  10. Nelson Andrade; Juliana A. Barreto Peixoto; Cláudia Silva; Fátima Martel; M. Beatriz P.P. Oliveira; Rita C. Alves. "Effects of a coffee silverskin extract upon different types of cancer cell lines". Paper presented in XV Encontro de Química dos Alimentos, 2021.
  11. Cláudia Silva; Nelson Andrade. "Obesity/type 2 diabetes mellitus biomarkers induce changes in nutrient transport that can contribute to breast cancer progression". Paper presented in i3S Annual Meeting, 2019.
  12. Silva, Cláudia; Carmo, Francisca; Martel, Fátima. "Assessment of the effects of dietary phenolic acids on carcinogenic traits and glucose and glutamine uptake in breast cancer MCF-7 cells". Paper presented in 8TH i3S Annual Meeting, 2019.
  13. Silva, Cláudia; Carmo, Francisca; Martel, Fátima. "Assessment of the effects of dietary phenolic acids on carcinogenic traits and glucose and glutamine uptake in breast cancer MCF-7 cells". Paper presented in 11th Symposium on Metabolism – Ageing & Metabolism, 2019.
  14. Nelson Andrade; Cláudia Marques; Sara Andrade; Cláudia Silva; Ilda Rodrigues; Luísa Guardão; João T. Guimarãens; et al. "Metabolic and microbiome changes in the intestinal environment induced by fructose-feeding in rats is affected by chrysin". Paper presented in 11th Symposium on Metabolism – Ageing & Metabolism, 2019.
  15. Silva, Cláudia; Nelson Andrade; Fátima Martel. "Obesity/type 2 diabetes mellitus biomarkers induce changes in nutrient transport that can promote breast cancer progression". Paper presented in 11th Symposium on Metabolism – Ageing & Metabolism, 2019.
  16. Silva, Cláudia; Nelson Andrade; Fátima Martel. "Obesity/type 2 diabetes mellitus biomarkers induce changes in proliferation, viability, migration, apoptosis and nutrient transport in breast cancer cells". Paper presented in IsCAM 2019 6th Annual Meeting – Cancer metabolic rewiring mapping the road to clinical translation, 2019.
  17. Silva, Cláudia; Ana Correia-Branco; Nelson Andrade; António C. Ferreira; Miguel L. Soares; Pierre Sonveaux; Jean Stephenne; Fátima Martel. "Selective pro-apoptotic and antimigratory effect of polyphenol complex catechin:lysine 1:2 in breast, pancreas and colon cancer cell lines". Paper presented in IsCAM 2019 6th Annual Meeting – Cancer metabolic rewiring mapping the road to clinical translation, 2019.
  18. L. Monteiro; A. Gomes; C. Silva; F. Martel; R. Mendes; F. Paz; B.J.M Leite Ferreira; T.M. Santos. "Novel anticancer metallodrugs". Paper presented in 4th Meeting of Medicinal Biotechnology, 2019.
  19. Silva, Cláudia; A. Correia-Branco; N. Andrade; P. Sonveaux; J. Stephenne; F. Martel. "Selective pro-apoptotic and antimigratory effect of a Catechin:Lysine complex (1:2) in cancer cell lines". Paper presented in 26th Porto Cancer Meeting & Porto-Bordeaux Joint Meeting – The Cancer Ecosystem, 2019.
  20. Silva. C; Sonveaux. P; Stephenne. J; Martel. F. "Potent cytotoxic, antiproliferative, pro-apoptotic and antimigratory effect of a Catechin:Lysine complex in pancreas cancer cell lines". Paper presented in 7TH i3S Annual Meeting, 2018.
  21. Silva. C; Sonveaux. P; Stephenne. J; Martel. F. "Potent cytotoxic, antiproliferative, pro-apoptotic and antimigratory effect of a Catechin:Lysine complex in pancreas cancer cell lines". Paper presented in 10º Simpósio de Metabolismo – Imunometabolismo, 2018.
  22. Andrade. N; Silva. C; Martel. F. "The effect of oxidative stress induced by tert-butylhydroperoxide (TBH) upon in vitro intestinal sugar transport". Paper presented in 10º Simpósio de Metabolismo – Imunometabolismo, 2018.
  23. C.Silva; A.Correia-Branco; P.Sonveaux; J.Stephenne; F.Martel. "Therapeutic potential of Catechin:Lysine complex in breast cancer cell lines". Paper presented in 25th Porto Cancer Meeting – Cancer Wars: The Immune Force Awakens, 2018.
  24. Silva. C; Correia-Branco. A; Sonveaux. P; Stephenne. J; Martel. F. "Potent pro-apoptotic, cytotoxic, antiproliferative and antimigratory effect of a Catechin:Lysyne complex in breast cancer cell lines". Paper presented in 9º Simpósio de Metabolismo, 2017.
  25. Andrade. N; Rodrigues. I; Silva. C; Keating. I; Martel. F. "Effects of dietary polyphenol Chrysin upon an animal model of Metabolic Syndrome induced by Fructose". Paper presented in 9º Simpósio de Metabolismo, 2017.
  26. I.Amaral; C.Silva; A.Correia-Branco; F.Martel. "Metformin interferes with glucose celular uptake by both estrogen and progesterone receptor-positive (MCF7) and receptor-negative (MDA-MB-231) breast cancer cell lines". Paper presented in 12h Yes Meeting, 2017.
  27. I.Amaral; C.Silva; A.Correia-Branco; F.Martel. "The anticarcinogenic effect of metformin on breast cancer cells: impact on nutrient uptake". Paper presented in 24th Cancer Meeting, 2017.
  28. I.Amaral; C.Silva; A.Correia-Branco; F.Martel. "The effect of metformin on nutrient uptake by breast cancer cells". Paper presented in VI AEICBAS BIOMEDICAL CONGRESS, 2017.
  29. I.Amaral; C.Silva; F.Martel. "The effect of metformin on nutrient uptake by breast cancer cells". Paper presented in IJUP’17 - 10º Encontro de Jovens Investigadores da Universidade do Porto, 2017.
  30. Carletti J V; Silva C R; Correia-Branco A; Andrade N; Martel F. "Influência de diferentes concentrações de ácido fólico na resposta de células trofoblasticas humanas (células BeWo) ao stress oxidativo". Paper presented in 7º Simpósio em Metabolismo, 2016.
  31. C.Silva; C.Nunes; A.Correia-Branco; J.Araújo; F.Martel. "A insulina possui um efeito antiproliferativo em trofoblastos extravilositários humanos de primeiro trimestre, com consequências no processo de placentação". Paper presented in 7º Simpósio em Metabolismo, 2015.
  32. Silva, Cláudia; C.Silva; A.Correia-Branco; F.Martel. "O efeito pró-carcinogénico de 17ß-estradiol em células MCF-7 não é dependente da interferência com a captação celular de glicose". Paper presented in 7º Simpósio em Metabolismo, 2015.
  33. C.Silva; C.Nunes; A.Correia-Branco; F.Martel. "Insulin exhibits na antiproliferative effect in first trimester human extravillous trophoblasts". Paper presented in IJUP’ 2015 - 8º Encontro de Jovens Investigadores da Universidade do Porto, 2015.
  34. C.Nunes; C.Silva; A.Correia-Branco; F.Martel. "The procarcinogenic effect of 17 ß-estradiol in MCF-7 cells is not related to interference with glucose cellular uptake". Paper presented in IJUP’ 2015 - 8º Encontro de Jovens Investigadores da Universidade do Porto, 2015.
Journal article
  1. Pinto-Leite, Mariana; Martins, Diana; Ferreira, António Carlos; Silva, Cláudia; Trindade, Fábio; Saraiva, Francisca; Vitorino, Rui; et al. "The Role of Chlorella and Spirulina as Adjuvants of Cardiovascular Risk Factor Control: A Systematic Review and Meta-Analysis of Randomised Controlled Trials". Nutrients 17 6 (2025): 943. https://doi.org/10.3390/nu17060943.
    10.3390/nu17060943
  2. Pinto, Sara; Andrade, Nelson; Carmo, Francisca; Silva, Cláudia; Martel, Fátima. "The cytotoxic effect of crocin and chrysin on the AsPC-1 pancreatic cancer cell line is related to inhibition of nutrient uptake". PharmaNutrition 31 (2025): 100432. https://doi.org/10.1016/j.phanu.2025.100432.
    10.1016/j.phanu.2025.100432
  3. Andrade, Nelson; Rodrigues, Ilda; Carmo, Francisca; Campanher, Gabriela; Bracchi, Isabella; Lopes, Joanne; Patrício, Emília; et al. "Sustainable Utilization of Coffee Pulp, a By-Product of Coffee Production: Effects on Metabolic Syndrome in Fructose-Fed Rats". Antioxidants 14 3 (2025): 266. https://doi.org/10.3390/antiox14030266.
    10.3390/antiox14030266
  4. Gabriela Campanher; Nelson Andrade; Joanne Lopes; Cláudia Silva; Maria João Pena; Ilda Rodrigues; Fátima Martel. "The Counteracting Effect of Chrysin on Dietary Fructose-Induced Metabolic-Associated Fatty Liver Disease (MAFLD) in Rats with a Focus on Glucose and Lipid Metabolism". Molecules (2025): https://doi.org/10.3390/molecules30020380.
    10.3390/molecules30020380
  5. Monteiro, Luís P.G.; Gomes, A.; Silva, Cláudia; Mendes, Ricardo F.; Almeida Paz, Filipe A.; Chernyshov, Dmitry; Rocha, J.; et al. "Towards targeted cancer therapy: Synthesis, characterization, and biological activity of a new Cu(II)-ibuprofen-2,2'-dipyridylamine metal complex". Heliyon 11 1 (2025): e41323. https://doi.org/10.1016/j.heliyon.2024.e41323.
    10.1016/j.heliyon.2024.e41323
  6. Ferreira, Diana Melo; Barreto-Peixoto, Juliana; Andrade, Nelson; Machado, Susana; Silva, Cláudia; Lobo, Joana C.; Nunes, Maria A.; et al. "Comprehensive analysis of the phytochemical composition and antitumoral activity of an olive pomace extract obtained by mechanical pressing". Food Bioscience 61 (2024): 104759. http://dx.doi.org/10.1016/j.fbio.2024.104759.
    10.1016/j.fbio.2024.104759
  7. André Cristovão; Nelson Andrade; Fátima Martel; Cláudia Silva. "Effect of Sodium-Glucose Co-Transporter 2 Inhibitors Combined with Metformin on Pancreatic Cancer Cell Lines". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25189932.
    10.3390/ijms25189932
  8. Martins, Diana; Silva, Cláudia; Ferreira, António Carlos; Dourado, Sara; Albuquerque, Ana; Saraiva, Francisca; Batista, Ana Beatriz; et al. "Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis". Biomolecules 14 6 (2024): 731. http://dx.doi.org/10.3390/biom14060731.
    10.3390/biom14060731
  9. Joana Gonçalves; Sara Pinto; Francisca Carmo; Silva, Cláudia; Nelson Andrade; Fátima Martel. "Additive Cytotoxic and Colony-Formation Inhibitory Effects of Aspirin and Metformin on PI3KCA-Mutant Colorectal Cancer Cells". International Journal of Molecular Sciences 25 10 (2024): 5381. https://www.mdpi.com/1422-0067/25/10/5381.
    Open access • Published
  10. Barreto-Peixoto, Juliana A.; Silva, Cláudia; Costa, Anabela S. G.; Álvarez-Rivera, Gerardo; Cifuentes, Alejandro; Ibáñez, Elena; Oliveira, M. Beatriz P. P.; et al. "A Prunus avium L. Infusion Inhibits Sugar Uptake and Counteracts Oxidative Stress-Induced Stimulation of Glucose Uptake by Intestinal Epithelial (Caco-2) Cells". Antioxidants 13 1 (2023): 59. http://dx.doi.org/10.3390/antiox13010059.
    10.3390/antiox13010059
  11. Teixeira, Rita Almeida; Silva, Cláudia; Ferreira, António Carlos; Martins, Diana; Leite-Moreira, Adelino; Miranda, Isabel M.; Barros, António S.. "The Association between Gestational Diabetes and the Microbiome: A Systematic Review and Meta-Analysis". Microorganisms 11 7 (2023): 1749. http://dx.doi.org/10.3390/microorganisms11071749.
    10.3390/microorganisms11071749
  12. Torres, Sílvia M.; Carmo, Francisca P.; Monteiro, Luís C.; Silva, Cláudia; Andrade, Nelson; Martel, Fátima. "Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line". Canadian Journal of Physiology and Pharmacology 101 2 (2023): 90-105. http://dx.doi.org/10.1139/cjpp-2022-0260.
    10.1139/cjpp-2022-0260
  13. Rodrigues, Helena; Silva, Cláudia; Martel, Fátima. "The effects of aspartame on the HTR8/SVneo extravillous trophoblast cell line". Reproductive Biology 22 3 (2022): 100678. http://dx.doi.org/10.1016/j.repbio.2022.100678.
    10.1016/j.repbio.2022.100678
  14. Carmo, F.; Silva, C.; Martel, F.. "Inhibition of Glutamine Cellular Uptake Contributes to the Cytotoxic Effect of Xanthohumol in Triple-Negative Breast Cancer Cells". Nutrition and Cancer 74 9 (2022): 3413-3430. http://dx.doi.org/10.1080/01635581.2022.2076889.
    10.1080/01635581.2022.2076889
  15. Pinto-Ribeiro, Lígia; Silva, Cláudia; Andrade, Nelson; Martel, Fátima. "a-tocopherol prevents oxidative stress-induced proliferative dysfunction in first-trimester human placental (HTR-8/SVneo) cells". Reproductive Biology 22 1 (2022): 100602. http://dx.doi.org/10.1016/j.repbio.2022.100602.
    10.1016/j.repbio.2022.100602
  16. Silva, Cláudia; Andrade, Nelson; Guimarães, João Tiago; Cardoso, Emília; Meireles, Catarina; Pinto, Vanessa; Paiva, Joana; Martel, Fátima. "The pro-proliferative effect of insulin in human breast epithelial DMBA -transformed and non-transformed cell lines is PI3K -, mTOR - and GLUT1 -dependent". Cell Biochemistry and Function 40 2 (2022): 127-137. http://dx.doi.org/10.1002/cbf.3681.
    10.1002/cbf.3681
  17. Silva, Cláudia. "The pro-proliferative effect of interferon-y in breast cancer cell lines is dependent on stimulation of ASCT2-mediated glutamine cellular uptake". Life Sciences 286 (2021): 120054-120054. http://dx.doi.org/10.1016/j.lfs.2021.120054.
    10.1016/j.lfs.2021.120054
  18. Silva, Cláudia. "Exploring Gunnera tinctoria: From Nutritional and Anti-Tumoral Properties to Phytosome Development Following Structural Arrangement Based on Molecular Docking". Molecules 26 19 (2021): 5935-5935. http://dx.doi.org/10.3390/molecules26195935.
    10.3390/molecules26195935
  19. Silva, Cláudia; Andrade, Nelson; Guimarães, João Tiago; Patrício, Emília; Martel, Fátima. "The in vitro effect of the diabetes-associated markers insulin, leptin and oxidative stress on cellular characteristics promoting breast cancer progression is GLUT1-dependent". European Journal of Pharmacology 898 (2021): 173980. http://dx.doi.org/10.1016/j.ejphar.2021.173980.
    10.1016/j.ejphar.2021.173980
  20. Teixeira, Estefânia; Silva, Cláudia; Martel, Fátima. "The role of the glutamine transporter ASCT2 in antineoplastic therapy". Cancer Chemotherapy and Pharmacology 87 4 (2021): 447-464. http://dx.doi.org/10.1007/s00280-020-04218-6.
    10.1007/s00280-020-04218-6
  21. Ferreira, B.J.M. Leite; Martel, F.; Silva, C.; Santos, T.M.; Daniel-da-Silva, A.L.. "Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation". Journal of Inorganic Biochemistry 213 (2020): 111258. http://dx.doi.org/10.1016/j.jinorgbio.2020.111258.
    10.1016/j.jinorgbio.2020.111258
  22. Cordeiro, Adryana; Costa, Raquel; Andrade, Nelson; Silva, Cláudia; Canabrava, Natalia; Pena, Maria João; Rodrigues, Ilda; Andrade, Sara; Ramalho, Andrea. "Does adipose tissue inflammation drive the development of non-alcoholic fatty liver disease in obesity?". Clinics and Research in Hepatology and Gastroenterology 44 4 (2020): 394-402. http://dx.doi.org/10.1016/j.clinre.2019.10.001.
    10.1016/j.clinre.2019.10.001
  23. Nogueira, João; Soares, Sofia F.; Amorim, Carlos O.; Amaral, João S.; Silva, Cláudia; Martel, Fátima; Trindade, Tito; Daniel-da-Silva, Ana L.. "Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy". Molecules 25 2 (2020): 333. http://dx.doi.org/10.3390/molecules25020333.
    10.3390/molecules25020333
  24. Silva, Cláudia; Correia-Branco, Ana; Andrade, Nelson; Ferreira, António Carlos; Soares, Miguel Luz; Sonveaux, Pierre; Stephenne, Jean; Martel, Fátima. "Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines". European Journal of Pharmacology 859 (2019): 172533. http://dx.doi.org/10.1016/j.ejphar.2019.172533.
    10.1016/j.ejphar.2019.172533
  25. Brandão, Paula; Guieu, Samuel; Correia-Branco, Ana; Silva, Cláudia; Martel, Fátima. "Development of novel Cu(I) compounds with vitamin B1 derivative and their potential application as anticancer drugs". Inorganica Chimica Acta 487 (2019): 287-294. http://dx.doi.org/10.1016/j.ica.2018.12.017.
    10.1016/j.ica.2018.12.017
  26. Andrade, Nelson; Andrade, Sara; Silva, Claúdia; Rodrigues, Ilda; Guardão, Luísa; Guimarães, João T.; Keating, Elisa; Martel, Fátima. "Chronic consumption of the dietary polyphenol chrysin attenuates metabolic disease in fructose-fed rats". European Journal of Nutrition 59 1 (2019): 151-165. http://dx.doi.org/10.1007/s00394-019-01895-9.
    10.1007/s00394-019-01895-9
  27. Andrade, Nelson; Marques, Cláudia; Andrade, Sara; Silva, Cláudia; Rodrigues, Ilda; Guardão, Luísa; Guimarães, João T.; et al. "Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats". Food & Function 10 8 (2019): 4566-4576. http://dx.doi.org/10.1039/c9fo01142k.
    10.1039/c9fo01142k
  28. Amaral, Inês; Silva, Cláudia; Correia-Branco, Ana; Martel, Fátima. "Effect of metformin on estrogen and progesterone receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cells". Biomedicine & Pharmacotherapy 102 (2018): 94-101. http://dx.doi.org/10.1016/j.biopha.2018.03.008.
    10.1016/j.biopha.2018.03.008
  29. Carletti, Jaqueline Vieira; Correia-Branco, Ana; Silva, Claudia Raquel; Andrade, Nelson; Silva, Lenir Orlandi Pereira; Martel, Fátima. "The effect of oxidative stress induced by tert-butylhydroperoxide under distinct folic acid conditions: An in vitro study using cultured human trophoblast-derived cells". Reproductive Toxicology 77 (2018): 33-42. http://dx.doi.org/10.1016/j.reprotox.2018.02.003.
    10.1016/j.reprotox.2018.02.003
  30. Andrade, Nelson; Silva, Cláudia; Martel, Fátima. "The effect of oxidative stress upon intestinal sugar transport: an in vitro study using human intestinal epithelial (Caco-2) cells". Toxicology Research 7 6 (2018): 1236-1246. http://dx.doi.org/10.1039/c8tx00183a.
    10.1039/c8tx00183a
  31. Anacleto, Beatriz; Gomes, Pedro; Correia-Branco, Ana; Silva, Cláudia; Martel, Fátima; Brandão, Paula. "Design, structural characterization and cytotoxic properties of copper(I) and copper(II) complexes formed by vitamin B 3 type". Polyhedron 138 (2017): 277-286. http://dx.doi.org/10.1016/j.poly.2017.09.030.
    10.1016/j.poly.2017.09.030
  32. Nunes, C.; Silva, C.; Correia-Branco, A.; Martel, F.. "Lack of effect of the procarcinogenic 17ß-estradiol on nutrient uptake by the MCF-7 breast cancer cell line". Biomedicine & Pharmacotherapy 90 (2017): 287-294. http://dx.doi.org/10.1016/j.biopha.2017.03.069.
    10.1016/j.biopha.2017.03.069
  33. Silva, Cláudia; Nunes, Catarina; Correia-Branco, Ana; Araújo, João R.; Martel, Fátima. "Insulin Exhibits an Antiproliferative and Hypertrophic Effect in First Trimester Human Extravillous Trophoblasts". Reproductive Sciences 24 4 (2016): 582-594. http://dx.doi.org/10.1177/1933719116667220.
    10.1177/1933719116667220
Magazine article
  1. Nelson Andrade; Cláudia Marques; Sara Andrade; Cláudia Silva; Ilda Rodrigues; Luísa Guardão; João T. Guimarães; et al. "Metabolic and microbiome changes in the intestinal environment induced by fructose-feeding in rats is affected by chrysin", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-dez-2019/.
  2. Silva, Cláudia; Nelson Andrade; Fátima Martel. "Obesity/type 2 diabetes mellitus biomarkers induce changes in nutrient transport that can promote breast cancer progression", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-dez-2019/.
  3. F. C. Carmo; C. Silva; F. Martel. "Assessment of the effects of dietary phenolic acids on carcinogenic traits and glucose and glutamine uptake in breast cancer MCF-7 cells", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-dez-2019/.
  4. Andrade. N; Silva. C; Martel. F.. "The effect of oxidative stress induced by tert-butylhydroperoxide (TBH) upon in vitro intestinal sugar transport,", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-mar-2019/.
  5. I.Amaral; C.Silva; A.Correia-Branco; F.Martel. "Metformin induces an increase in glucose uptake and lactate production by breast cancer cells", Porto Biomedical Journal, 2019, doi: 10.1097/j.pbj.0000000000000037.
  6. Andrade. N; Rodrigues. I; Silva. C; Keating. I; Martel. F. "Effects of dietary polyphenol Chrysin upon an animal model of Metabolic Syndrome induced by Fructose", Porto Biomedical Journal, 2019, doi: 10.1097/j.pbj.0000000000000037.
  7. Silva. C; Correia-Branco. A; Sonveaux. P; Stephenne. J; Martel. F. "Potent pro-apoptotic, cytotoxic, antiproliferative and antimigratory effect of a Catechin:Lysine complex in breast cancer cell lines", Porto Biomedical Journal., 2019, doi: 10.1097/j.pbj.0000000000000037.
  8. Silva. C; Sonveaux. P; Stephenne. J; Martel. F. "Potent cytotoxic, antiproliferative, pro-apoptotic and antimigratory effect of a Catechin:Lysine complex in pancreas cancer cell lines", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-mar-2019/.
  9. Andrade. N; Andrade. S; Silva. C; Rodrigues. I; Guardão. L; Guimarães. JT; Keating. E; Martel. F. "The dietary polyphenol chrysin attenuates metabolic disease in the rat induced by fructose feeding", Revista Portuguesa de Diabetes, 2019, http://www.revportdiabetes.com/rpd-mar-2019/.
  10. Carletti J V; Silva C R; Correia-Branco A; Andrade N; Martel F. "Influência de diferentes concentrações de ácido fólico na resposta de células trofoblasticas humanas (células BeWo) ao stress oxidativo", Revista Portuguesa de Diabetes, 2015
  11. C.Nunes; C.Silva; A.Correia-Branco; F.Martel. "O efeito pró-carcinogénico de 17ß-estradiol em células MCF-7 não é dependente da interferência com a captação celular de glicose", Revista Portuguesa de Diabetes, 2015
  12. C.Silva; C.Nunes; A.Correia-Branco; J.Araújo; F.Martel. "A insulina possui um efeito antiproliferativo em trofoblastos extravilositários humanos de primeiro trimestre com consequências no processo de placentação", Revista Portuguesa de Diabetes, 2015
Thesis / Dissertation
  1. "The role of nutrient transport by cancer cells in the interaction between type 2 diabetes mellitus and breast cancer". PhD, Universidade do Porto Faculdade de Medicina, 2022.
  2. Silva, Cláudia. "O efeito da insulina na placentação: estudos in vitro com células HTR8/SVneo". Master, Universidade do Minho Escola de Ciências, 2015.
  3. Silva, Cláudia. "Relação entre as proteínas do checkpoint mitótico e a proteína Splindly durante a ligação dos cromossomas mitóticos aos microtúbulos". Degree, Cooperativa de Ensino Superior Politécnico e Universitário, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10 Antioxidant, anti-inflammatory, anti-diabetic, and cytotoxic potential of ethanolic leaf extracts from Englerina woodfordiodes M. Gilbert and Oncocalyx fischeri (Ebgl.) M. Gilbert The 5th International Electronic Conference on Foods (Foods 2024)
Foods (MDPI)
2024/07/19 Enhanced the antidiabetic effect of chrysin through metal complexation and nanoencapsulation Summit Research
(Aveiro, Portugal)
2024/06 Enhanced the antidiabetic potential of chrysin through metal complexation and nanoencapsulation 10th Iberian meeting on colloids and interfaces
(Coimbra, Portugal)
2024/05/18 Development of a novel coordination polymer comprising Cu(II) and chrysin with anticancer potential 4th Inorganic & Bioinorganic Chemistry Conference
Portuguese Chemistry Society (Lisboa, Portugal)
2024/05/18 Enhanced antidiabetic Effect of chrysin by complexation with Cu(II) and Co(II) ions 14th Inorganic & Bioinorganic Chemistry Conference
Portuguese Chemistry Society (Lisbon, Portugal)
2024/05/08 Exploration of the anticancer effect of the combination of metformin and aspirin in colorectal cancer cell lines 17.º Young Researchers Meeting of U.Porto (IJUP)
University of Porto, Faculty of Economics (Porto, Portugal)
2023/11/25 Neurological deficits and functional independence after stroke: an exploratory analysis of urine and plasma metabolomics 1º congresso Luso-Brasileiro de Cirurgia Tóracica (SPCCTV)
(Algarve, Portugal)
2022/02/10 Xanthumol inhibits glutamine celular uptake resulting in a cytotoxic effect in triple-negative breast cancer cells SPF Meeting 2022
Porto Palácio Hotel & SPA (Porto, Portugal)
2022/02/10 Effects of a coffee roast by-product extract on different tumoral lines: a “sustainable” call for further studies SPF Meeting 2022
Porto Palácio Hotel & SPA (Porto, Portugal)
2022/02/10 Insulin stimulates proliferation of human breast epithelial DMBA-transformed and non-transformed cell lines by a PI3K-, mTOR- and GLUT1-depedent mechanism SPF Meeting 2022
Porto Palácio Hotel & SPA (Porto, Portugal)
2021/05/05 Assessing the effects of dietary phenolic acids on carcinogenic traits and glutamine and glucose uptake in breast cancer (MCF-7) cells 14º Encontro Investigação Jovem
online (Porto)
2021/02/19 In vitro evaluation of the effect of oxidative stress in placental function SPF Meeting 2021
(Lisboa, Portugal)
2021/02/19 Metabolic and microbiome alterations in the intestinal environment induced by fructose feeding in rats are affected by chrysin SPF Meeting 2021
(Lisboa, Portugal)
2021/02/18 Metabolic markers changed in type 2 diabetes mellitus interfere with glutamine uptake and ASCT2 expression in breast cancer cells SPF Meeting 2021
(Lisboa, Portugal)
2019/02/13 In vitro evaluation of nanostructured functionalized platforms for the sustained delivery of cisplatin 12TH Meeting of Young Researchers of University of Porto
(Porto, Portugal)
2019/02/06 Selective pro-apoptotic and antimigratory effect of catechin:lysine complex (1:2) in cancer cell lines SPF Meeting 2019
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2018/10 Protective effect of chrysin on frutose induced metabolic syndrome in rats XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Lisboa, Portugal)
2018/10 The dietary polyphenol chrysin attenuates metabolic disease in the rat induced by fructose feeding 10º Simpósio de Metabolismo – Imunometabolismo
(Porto)
2017/10 Metformin induces an increase in glucose uptake and lactate production by breast cancer cells 9º Simpósio de Metabolismo
(Porto, Portugal)
2017/02 Antiproliferative and hypertrophic effect of insulin in first trimester human extravillous trophoblasts XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - 2024/10/01 Effect of SGLT2 Inhibitors on pancreatic cancer initiation and progression
Co-supervisor
 Metabolismo – Biopatologia e Experimentação (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/04 - 2022/03 The effect of aspartame on placentation: an in vitro study
Co-supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/09 - 2021/09 Effect of dietary polyphenols on glutamine uptake by breast cancer cells
Co-supervisor
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11 - 2021/07 Effect of gallic acid on glucose uptake by the AsPC-1 pancreatic cell line
Co-supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09 - 2020/12 In vitro evaluation of the effect of oxidative stress in placental function
Co-supervisor
 Toxicologia Analítica Clínica e Forense (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/02 - 2020/07 Study of the antitumoral effects of phenolic acids inthe AsPC-1 pancreatic cancer cell line
Co-supervisor
 Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/01 - 2019/07 Effect of dietary phenolic acids on glucose and glutamine uptake by breast cancer cells: relationship with their anticarcinogenic effect
Co-supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09 - 2017/07 Metformin effect on breast cancer cells
Co-supervisor
 Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/01/01 - 2019/10/30 11th Symposium in Metabolism ¿ Ageing & Metabolism (2019/10/30 - 2019/10/30)
Symposium (Member of the Organising Committee)
 Universidade do Porto Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/07/24 Efeitos in vitro da Metformina e Aspirina no Adenocarcinoma Colorretal
(Thesis) Main arguer
 Joana Blanquet André Gonçalves (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2023/06/15 The association between gestational diabetes and the microbiome: a systematic review and meta-analysis
(Thesis) Main arguer
 Rita Almeida Ramos Teixeira (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/07/22 Drug repurposing in oncology: in vitro effect of metformin and aspirin in colorectal cancer cells
(Thesis) Main arguer
 Sara Patrícia Gonçalves Pinto (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09/01 - Current Invited Assistant Professor of Human Metabolism in Master in Medicine (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2024/07/01 - Current Lecture of the curricular unit Functional Foods and Nutraceuticals: Metabolic Effects of the Doctoral Programme in Metabolism - Clinical and Experimental (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2018/06 - Current Teacher of practical classes, of curricular unit, Animal Cell Culture, of the Doctoral Program in Metabolism – Clinic and Experimental, Master in Metabolism – Biopathology and experimental and Continuous Training Unit (Curso de mestrado (conclusão do curso de especialização)) Universidade do Porto Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/10/19 Press release about results obtained during my PhD project with professor Fátima Martel. This project was focussed on the identifying new molecular targets that link type 2 diabetes and initiation, promotion and progression of breast cancer and to development of new therapeutic approaches that prevent and control breast cancer in patients with type 2 diabetes. The results have the potential to translate into clinically significant data in the future. "Estudo da FMUP conclui que diabetes tipo 2 acelera progressão de cancro da mama" Jornal de Notícias

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current iScience Cell Press
2019/10/22 - 2019/10/29 Advancement in Medicinal Plant Research

Mentoring / Tutoring

Topic Student name
2018/05 - 2018/05 Study of the antitumoral effects of olive and fig extracts in the AsPC-1 pancreatic cancer cell line Nadia Janna
2015/01 - 2016/12 The effect of oxidative stress induced by tert-butylhydroperoxide under distinct folic acid conditions: an in vitro study using human trophoblast cell lines Jaqueline Viera Carletti

Other jury / evaluation

Activity description Institution / Organization
2024/10/25 - Current Posters section - 2nd Conference of the Doctoral Program in Metabolism – Clinical and Experimental (MET-CONF 2024) Universidade do Porto Faculdade de Medicina, Portugal
2024/05/09 - 2024/05/09 Posters section - 17º Young Researchers Meeting of U.Porto (IJUP) Universidade do Porto Faculdade de Economia, Portugal
Distinctions

Award

2024 Honourable mention
2019 Best poster communication
Universidade do Porto Faculdade de Medicina, Portugal