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Miguel Gomes Cardoso. Completed the Mestrado in Ciências Biofarmacêuticas in 2017/12 by Universidade de Lisboa Faculdade de Farmácia and Licenciatura in Bioquímica in 2015/07 by Universidade de Lisboa Faculdade de Ciências. Attends the Doutoramento in Farmácia by Universidade de Lisboa Faculdade de Farmácia since 2021/01/01. Published 5 articles in journals. Participated in 2 event(s). Participates and/or participated as Research Fellow in 2 project(s). In their professional activities interacted with 52 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Flow Cytometry; FlowJo; .
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Identification

Personal identification

Full name
Miguel Gomes Cardoso

Citation names

  • Cardoso, Miguel

Author identifiers

Ciência ID
BB16-EC1F-F9CC
ORCID iD
0000-0002-2566-4925
Researcher Id
ABD-1410-2021

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2021/01/01 - 2025
Ongoing
 Farmácia (Doutoramento)
Major in Microbiologia
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Brasília Faculdade de Medicina, Brazil
"Antibodies and peptides against SARS-CoV-2 infection - from ICU patients to therapy" (THESIS/DISSERTATION)
2015/10 - 2017/12
Concluded
 Ciências Biofarmacêuticas (Mestrado)
Major in Sem especialização
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Novel Strategy to Detect and Localize Latent HIV Reservoirs" (THESIS/DISSERTATION)
 17 valores
2012/09 - 2015/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/04/06 - 2024/04/17 Visiting Researcher (Research) Universidade de Brasília Faculdade de Medicina, Brazil
2018/01/01 - 2020/12/31 Research Assistant (Research) Universidade de Lisboa - Associação para o Desenvolvimento do Ensino e Investigação da Microbiologia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Grant

Designation Funders
2021/01/01 - Current Antibodies and peptides against SARS-CoV-2 infection - from ICU patients to therapy
2020.08317.BD
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Brasília Faculdade de Medicina, Brazil
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2024/06/30 ArmCART: Promoting T-cell memory and innate immunity to increase the efficacy of CAR-T cells
2022.07746.PTDC
10.54499/2022.07746.PTDC
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01 - 2020/12/31 Desenvolvimento de anticorpos para degenerescência macular
BI-VisionAb
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 TechnoPhage SA
Concluded
2018/01 - 2019/12 Immunogenicity in Fabry disease: the role of enzyme replacement therapy
IIR-PRT-001425
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Shire Plc
Concluded

Contract

Designation Funders
2023/01/01 - 2024/06/30 O papel dos microRNAs na resposta imunitária e celular á vacinação COVID-19 em doentes hepáticos
2022.08837.PTDC
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Investigação do Medicamento
UID/DTP/04138/2019
154706UID
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Alterações na imunidade celular induzidas pelas vacinas contra a COVID-19 em indivíduos com doença hepática crónica". Paper presented in Congresso Português de Hepatologia, Figueira da Foz, 2024.
  2. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Chronic liver disease patients present a weak SARS-CoV-2 specific cellular immune response". Paper presented in UEG Week Vienna 2024, Vienna, 2024.
  3. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Changes in cellular immunity induced by COVID-19 vaccines in patients with chronic liver disease". Paper presented in EALS congress 2024, Milan, 2024.
  4. Henrique, Mariana Moura; Palma, Carolina; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Long-term cellular immune response to COVID-19 vaccination in patients with chronic liver disease". Paper presented in EALS, 2023.
  5. Casado, Igor; S. Palma, Carolina; Cardoso, Miguel; Godinho-Santos, Ana; Rodrigues, Ana Clara; Trindade, Carlos; Fonseca, João Eurico; Goncalves, Joao. "Characterization of humoral and cellular immune responses in rheumatoid arthritis patients following BNT162b2 vaccination". Paper presented in iMed.Ulisboa Posgraduate Meeting, Lisbon, 2023.
Conference poster
  1. Palma, Carolina; Henrique, Mariana; Simão, AL; Godinho-Santos, A.; Cardoso, Miguel; Fernandes, DAE; Carvalhana, S; et al. "Patients with chronic liver disease demonstrate an impaired SARS-CoV-2- specific cellular immune response". Paper presented in XV iMed.ULisboa Postgraduated Students Meeting, 2024.
Journal article
  1. Ana Gonçalves; Sónia Velho; Bárbara Sucena Rodrigues; Maria Lobo Antunes; Miguel Cardoso; Ana Godinho-Santos; João Gonçalves; António Marinho. "The Immunomodulatory Activity of High Doses of Vitamin D in Critical Care Patients with Severe SARS-CoV-2 Pneumonia—A Randomized Controlled Trial". Nutrients (2025): https://www.mdpi.com/2072-6643/17/3/540.
    10.3390/nu17030540
  2. Isabella de Souza Mota; Miguel Cardoso; João Bueno; Ingrid Gracielle Martins da Silva; João Gonçalves; Sonia N. Bao; Brenno A.D. Neto; et al. "Intragenic antimicrobial peptide Hs02 toxicity against leukemia cell lines is associated with increased expression of select pyroptotic components". Toxicology in Vitro (2024): http://dx.doi.org/10.1016/j.tiv.2024.105945.
    10.1016/j.tiv.2024.105945
  3. Márcia Luana Gomes Perfeito; Fábio de Oliveira Silva Ribeiro; Joilson Ramos de Jesus; Leiz Véras; Alyne Rodrigues de Araújo Nobre; Everton Moraes Lopes; José Carlos Eloi de Queiroz; et al. "Extraction and Identification of Flavonoids from the Leaves of Pilocarpus microphyllus: Focus on Antioxidant Activity and Neuroprotective Profile". Drugs and Drug Candidates (2024): http://dx.doi.org/10.3390/ddc3040045.
    10.3390/ddc3040045
  4. Francisco Marcelino Almeida de Araújo; Emely Thainara Almeida de Araújo; Miguel Gomes Cardoso; Bruno Silva Sá; Leiz Maria Costa Veras; Andreanne Gomes Vasconcelos; David Fernandes Lima; et al. "Anticorrosive properties in 1020 steel of an alkaloid-rich extract obtained from the jaborandi biomass (Pilocarpus microphyllus staff ex wardlew) of the pilocarpine industrial production chain". Rendiconti Lincei. Scienze Fisiche e Naturali (2024): http://dx.doi.org/10.1007/s12210-024-01253-w.
    10.1007/s12210-024-01253-w
  5. Ana Luisa Alves Nogueira Barros; Vladimir Costa Silva; Atvaldo F. Ribeiro-Junior; Miguel G. Cardoso; Samuel R. Costa; Moraes, C. B.; Cecília G. Barbosa; et al. "Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra)". Pharmaceutics (2024): http://dx.doi.org/10.3390/pharmaceutics16020190.
    10.3390/pharmaceutics16020190
  6. Saruga, Andreia; Brito, Paula; Cardoso, Miguel; Goncalves, Joao. Corresponding author: Goncalves, Joao. "Methods and cell-based strategies to produce antibody libraries: current state". Applied Microbiology and Biotechnology 105 19 (2021): 7215-7224. http://dx.doi.org/10.1007/s00253-021-11570-x.
    10.1007/s00253-021-11570-x
  7. Santos, Joana; Cardoso, Miguel; Moreira, Irina S.; Goncalves, Joao; Correia, João D. G.; Cabo Verde, Sandra; Melo, Rita. Corresponding author: Melo, Rita. "Integrated in Silico and Experimental Approach towards the Design of a Novel Recombinant Protein Containing an Anti-HER2 scFv". International Journal of Molecular Sciences 22 7 (2021): 3547-3547. http://dx.doi.org/10.3390/ijms22073547.
    Published • 10.3390/ijms22073547
  8. Ministro, Joana H.; Oliveira, Soraia S.; Oliveira, Joana G.; Cardoso, Miguel; Aires-da-Silva, Frederico; Corte-Real, Sofia; Goncalves, Joao. "Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening". Applied Microbiology and Biotechnology (2020): http://dx.doi.org/10.1007/s00253-020-10423-3.
    Published • 10.1007/s00253-020-10423-3
  9. Cunha-Santos, Catarina; Perdigao, Pedro Ricardo Lucas; Martin, Francisco; Oliveira, Joana Gomes; Cardoso, Miguel; Manuel, Ana; Taveira, Nuno; Goncalves, Joao. "Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody". Cellular and Molecular Life Sciences (2019): http://dx.doi.org/10.1007/s00018-019-03334-8.
    Published • 10.1007/s00018-019-03334-8
  10. Goncalves, J.; Santos, M.; Acurcio, R.; Iria, I.; Gouveia, L.; Matos Brito, P.; Catarina Cunha-Santos, A.; et al. "Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition". Alimentary Pharmacology & Therapeutics 48 5 (2018): 507-522. http://dx.doi.org/10.1111/apt.14808.
    10.1111/apt.14808
Thesis / Dissertation
  1. "Novel Strategy to Detect and Localize Latent HIV Reservoirs". Master, Universidade de Lisboa Faculdade de Farmácia, 2017. http://hdl.handle.net/10451/34001.
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/03/31 - Current Here I have been working directly with patients' samples, where I perform samples inactivation (in a BSL-3 environment) and subsequently RNA extraction, and prepare and carry out the qRT-PCR. The daily volume of processed samples has been roughly 300.
Other
 Centro Diagnóstico COVID-19
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02/13 - 2020/02/13 This workshop was divided in two sessions. The first one was focused on the FlowJo's basic functions. The second session we learned more advanced features and tools to use to analyze flow cytometry data.
Workshop
 FlowJo Workshop
Instituto Gulbenkian de Ciência, Portugal

Mentoring / Tutoring

Topic Student name
2018/09 - 2022 Building a Synthetic Cell System for IgG Production and Selection Andreia Saruga
2019/10 - 2020/04 Engineered Bispecific CAR-T Cells for Specific Discovery in Breast Cancer Carolina Palma
2017/09 - 2018/09 Proimmunotoxin: a novel design strategy of immunotoxins applied to breast cancer Ana Margarida Manuel
2017/09 - 2018/09 Selection of Synthetic IgG Libraries by CRISPR Induced Variability Jéssica Nereu
2017/03 - 2017/07 Using Cells as Biosensors Ana Patrícia Vigarinho de Jesus Almeida