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Raquel Boia (RB) is a researcher at the Coimbra Institute for Clinical and Biomedical Research (iCBR) of the Faculty of Medicine of University of Coimbra (FMUC), which is part of CIBB (Center for Innovative Biomedicine and Biotechnology), University of Coimbra (UC). Raquel Boia is graduated in Biochemistry and concluded her MSc degree in Biochemistry, in 2013, aiming to unravel the potential of microglia-mediated neuroinflammation control as a therapeutic strategy for retinal neuroprotection in experimental models of glaucoma. Then, she was a research fellow in a FCT-funded project (PTDC/BIM-MEC/0913/2012). Afterward, she was granted a PhD fellowship (FCT, PD/BD/114115/2015) in the Inter-University Doctoral Program in Ageing and Chronic Diseases of UC. She studied the therapeutic benefits of the adenosine A3 receptor (A3R) agonist to retinal ganglion cells neuroprotection, identifying a potential treatment for vision loss in glaucoma. These years’ work culminated in several publications, in which her publication Boia et al, 2022, J Control Release, IF: 11.467 was selected to be featured in the cover, March 2022, after Editor-in-chief invitation, and it was identified as a Top 1-5% published scientific paper for UC. RB research outputs include 24 publications in leading peer-reviewed journals (7 as first author), with an average IF of 5.7, h-index of 16 and more than 820 citations (as of February 2024). All of her contributions to this scientific field culminated in the award in the Innovators category by The IAPB - Eye Health Hero Programme in 2021, which is a recognition based on her contribution in aiding vision and restoring sight all around the globe as an Innovator. Moreover, she was awarded the Prize L'Oréal Portugal Medals of Honor for Women in Science 2022, with the project “A new therapeutic approach to leverage vision restoration in glaucoma”. RB has been involved in scientific projects as, i) PI: L'Oréal Portugal Medals of Honor for Women in Science 2022; ii) TEAM MEMBER: 8 grants (3 awarded by FCT - 1 is an ongoing project; 1 funded by Bayer HealthCare; 3 funded by the FMUC and 1 funded by Manuel Rui Azinhais Nabeiro, Lda). The activities of academic supervision and guidance are reflected in, i) SUPERVISION: 4 master students (3 ongoing), 11 undergraduate students, 1 scholarship holder, 2 Summer Internships at UC and 4 elementary school students from summer internship program “Ciência Viva no Laboratório”; ii) GUIDANCE: 1 international Post-Doc during the stay in Portugal, 6 PhD students during Lab rotations, 5 master students, 10 undergraduate students and 1 scholarship holder. Her teaching activities are reflected in: laboratorial tutor of the Advanced Course in Vision Sciences from the PhD program in Health Sciences and of the Course of Sciences in Laboratory Animals, lectures in the Advanced Course in Vision Sciences of the PhD Programme in Health Sciences of FMUC; main examiner in a jury of Bsc degree and Msc thesis. Moreover, RB contributions are also reflected in 15 published abstracts from scientific meetings and 1 proceeding of international conference, 36 oral communications (12 as invited/presenting author), 80 poster presentations (as author/co-author). RB has also been participating as guest editor in several special issues, and to note the one from Frontiers in Neuroscience entitled “Molecular and cellular players of axonal regeneration in injured CNS”. She acted as a reviewer for Acta Biomaterialia; Molecular Neurobiology; Biomedicine Hub; Cells; IJMS; Journal of Clinical Medicine; Journal of Ophthalmology and Nutrients. RB has been actively participating in outreach science activities: World Sight Day, Brain Awareness Week and European Researchers Night. She is also team member of a science communication project Talk Neuro to Me (“Fala-me Neuro” in Portuguese) which is committed to foster neuroscience literacy and fight misinformation in the Portuguese community.
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Identification

Personal identification

Full name
Raquel Sofia Freitas Boia

Citation names

  • Boia, Raquel
  • Boia, R.

Author identifiers

Ciência ID
B914-BBE9-9F8C
ORCID iD
0000-0002-0479-3066
Scopus Author Id
56587954800

Email addresses

  • raquelfboia@gmail.com (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/09/27 - 2022/09/29
Concluded
 “Novel Challenges in Toxicology” (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/07/05 - 2022/07/07
Concluded
 “Competency based skills training in mice and rats” (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/05/20
Concluded
 Workshop L2B²-T: “Ajudar os alunos a reter, recuperar e aplicar conhecimentos: estratégias baseadas na evidência” (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10 - 2021/09/21
Concluded
 Inter-University Doctoral Programme in Ageing and Chronic Disease (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma" (THESIS/DISSERTATION)
 Approved with praise and distinction
2021/07/21
Concluded
 Workshop "Definição de Procedimento e Classificação de Severidade de Dor" (Outros)
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2021/05/06
Concluded
 Workshop "Comunicação de Experimentação Animal" (Outros)
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2016/11/28 - 2016/12/02
Concluded
 II Quantitative Fluorescence Microscopy Course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/01/11 - 2016/01/28
Concluded
 Biostatistics in Health Sciences, 6th edition (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/05/04 - 2015/05/15
Concluded
 Laboratory Animal Science Course - Category C (Outros)
Instituto de Biologia Molecular e Celular, Portugal
2015/03/30 - 2015/04/01
Concluded
 FRAME Training School in Experimental Design and Statistical Analysis of Biomedical Experiments (Outros)
Universidade de Coimbra, Portugal
2014/11/07 - 2014/11/08
Concluded
 "Profiling alterations in microglia dynamic properties by neuroinflammation" (Outros)
Faculty of Pharmacy of University of Lisbon (iMed.ULisboa), Portugal
2011 - 2013
Concluded
 Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulation of pro-inflammatory response of retina by adenosinergic system - Neuroinflammation/Neuroprotection" (THESIS/DISSERTATION)
 18
2013
Concluded
 Online Course on Laboratory Animal Science, covering topics recommended by FELASA for category B (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2009 - 2011
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 13,45
Affiliation

Science

Category
Host institution 		Employer
2019/10 - Current Contracted Researcher (Research) Vector B2B - Drug development - Association for Research in Biotechnology, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2013 - 2015 Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal

Others

Category
Host institution 		Employer
2022/07/10 - 2022/07/14 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Spain
2018/07/01 - 2018/07/30 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Spain
2015/04/12 - 2015/04/20 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Spain
Projects

Grant

Designation Funders
2015/10 - 2019/09 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma
PD/BD/114115/2015
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2023/03/12 - Current Deciphering the role of Piezo1 mechanosensitive channel in microglia-mediated glaucomatous neurodegeneration
2022.01354.PTDC
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Ongoing
2023/01 - 2026/12 A new therapeutic approach to leverage vision restoration in glaucoma.
n.a.
Principal investigator
Medalhas de Honra L’Oréal para as Mulheres na Ciência
Ongoing
2016/07 - 2019/12 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2015/12 - 2018/02 Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade
US2083156314
Researcher
Global Ophthalmology Awards Program - Bayer HealthCare
Concluded
2016/06 - 2017/07 Exosomes as amplifiers of inflammation: microglia-Müller cell communication in glaucoma.
GAI-Santander Totta 2016_224
Researcher
Universidade de Coimbra Faculdade de Medicina
Concluded
2014/01 - 2015/12 The potential protective effect of caffeine in the retina: relevance for the treatment of glaucoma.
n/a
Researcher
MANUEL RUI AZINHAIS NABEIRO LDA
Concluded
2015/04 - 2015/10 Biodegradable intravitreal porous implants for extended release of A3 adenosine receptor agonist for the protection of retinal ganglion cells
ASantiago.GAI2015
Researcher
Universidade de Coimbra Faculdade de Medicina
Concluded
2013/06 - 2015/09 From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma.
PTDC/BIM-MEC/0913/2012
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2013/05 - 2013/10 Adenosine A3 receptor: a new therapeutic target for the treatment of glaucoma?
GAI Santiago06.01.13
Researcher
Universidade de Coimbra Faculdade de Medicina
Concluded
Outputs

Publications

Conference abstract
  1. Sanches, Eliane Swely; Boia, Raquel; Maria H. Madeira; Leitão, Ricardo Alexandre; Baptista, FI; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Unveilling the impact of methylphenidate misuse on the retina". Paper presented in 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology, Lisbon, 2024.
    Published
  2. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Unveilling the effects of Methylphenidate on the retina of control and Attention-Deficit/Hyperactivity Disorder rat models". Paper presented in 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology, Porto, 2022.
    Published
  3. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Activation of the adenosine A3 receptor as a new strategy to rescue retinal ganglion cells from ischemic damage". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, 2021.
    Published
  4. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Intraocular biodegradable implants loaded with A3 receptor agonist rescue retinal ganglion cells from ischemic damage". Paper presented in 2021 CRS Virtual Annual Meeting, Web conference, 2021.
    Published
  5. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant". Paper presented in 3rd SPLC-CRS Young Scientists Virtual Meeting, Web conference, 2021.
    Published
  6. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Intraocular biodegradable implant loaded with adenosine A3 receptor agonist as a strategy for the treatment of glaucoma". Paper presented in 50.ª Reunião da Sociedade Portuguesa de Farmacologia, Coimbra, 2020.
    Published
  7. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Martins, J.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; et al. "Biodegradable intraocular implant loaded with adenosine A3 receptor agonist affords protection against retinal ischemic injury". Paper presented in 5th ISOPT Clinical: The International Symposium on Ocular Pharmacology & Therapeutics, The Retina Chapter, Valencia, 2019.
    Published
  8. Boia, Raquel; Martins, J.M.; Dias, Paulo A.N.; Galindo-Romero, C.; Vidal-Sanz, M.; Agudo-Barriuso, M.; de Sousa, Hermínio C.; et al. "A new drug delivery system for glaucoma patients: poly(e-caprolactone) biodegradable intravitreal implants". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Tailoring drug delivery systems to the patients¿ needs, Coimbra, 2018.
    Published
  9. Boia, Raquel; Martins, J.M.; Dias, Paulo A.N.; Galindo-Romero, C.; Vidal-Sanz, M.; Agudo-Barriuso, M.; de Sousa, Hermínio C.; et al. "Biodegradable Porous Intravitreal Implants for Extended Drug Release: An Opportunity For Retinal Ganglion Cell Neuroprotection?". Paper presented in ISER/BrightFocus 2017 meeting, Basic science catalyzing treatments for glaucoma, Atlanta, Georgia, 2017.
    Published
  10. alves, MP; Boia, Raquel; Campos, Elisa J.; Martins, João; Nunes, Sara; madeira, mh; Reis, Flávio; et al. "Early retinal changes in a rat model of prediabetes: assessment of blood-retinal barrier permeability, neural markers and inflammatory mediators". Paper presented in 7th Annual Meeting of IBILI, Coimbra, 2015.
    Published
  11. Inês Aires; Boia, Raquel; Catarina Neves; Madeira, Maria Helena Bica; Ambrósio, António F.; Santiago, Ana R.; Aires, I; Ambrósio, António Francisco; Ana Raquel Santiago. "A2A receptor blockade prevents microglia reactivity triggered by elevated hydrostatic pressure". Paper presented in Glia Meeting, Bilbao, 2015.
    Published
  12. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Tiago Martins; Ambrósio, António F.; Santiago, Ana Raquel. "Blockade of adenosine A2A receptor confers neuroprotection against retinal ischemia-reperfusion injury through the control of neuroinflammation". Paper presented in Glia Meeting, Bilbao, 2015.
    Published
Conference paper
  1. Aires, Inês Dinis; Boia, Raquel; Ribeiro-Rodrigues, Teresa M; Girao, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Exosomes from microglia under elevated pressure promote retinal neuroinflammation and degeneration". Paper presented in GLIA, Porto, 2019.
    10.1002/glia.23675
  2. Braga, Mara E.M.; Dias, Paulo A.N.; Boia, Raquel; Martins, J.M.; Ambrósio, A.F.; Santiago, A.R.; de Sousa, Hermínio C.. "Porous and Safe Ocular Implants Developed by scCO2 Foaming/Mixing for Increased Degradation Rate". Paper presented in 12th International Symposium on Supercritical Fluids (ISSF 2018), Juan-Les-Pins, 2018.
    Published
  3. Boia, Raquel. "Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology". Paper presented in 16th European Meeting on Supercritical Fluids (EMSF), Lisbon, 2017.
    Published
  4. Ambrósio, António Francisco; Aires, I; Catarina Neves; Boia, Raquel; Madeira, Maria Helena Bica; Ana Raquel Santiago. "Control of microglia reactivity elicited by elevated hydrostatic pressure through A2A receptor blockade.". Paper presented in Society for Neuroscience Annual Meeting ¿ Neuroscience 2015, Chicago, 2015.
    Published
Conference poster
  1. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Ambrósio; Rosa Cristina S Fernandes; Ana Paula Silva. "A pre-clinical study to analyze the retinal alterations in Attention Deficit/Hyperactivity Disorder (ADHD) and the effect of methylphenidate". Paper presented in 5th National Congress of ADHD (5º Congresso Nacional PHDA), 2022.
  2. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo; Maria H. Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Retinal alterations in Attention-Deficit/Hyperactivity Disorder and the effect of methylphenidate treatment: a pre-clinical study". Paper presented in 35th ECNP Congress, 2022.
  3. Sanches, Eliane Swely; Boia, R.; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Rosa Cristina S Fernandes; Ana Paula Pereira da Silva Martins. "Retinal alterations in Attention-deficit/Hyperactivity Disorder and control conditions with(out) methylphenidate treatment". Paper presented in 35th ECNP Congress, 2022.
  4. Cruz, Alexandra; Boia, Raquel; Gaspar, Rita; Sara Nunes; Baptista, FI; António Francisco Ambrósio; Hugo Fernandes. "Assessment of the impact of an early acute immune challenge on the diabetic retina". Paper presented in The Biochemistry Global Summit, 2022.
  5. Ambrosio, A.F. ; Cruz, Alexandra ; Boia, Raquel; Fernandes, Hugo; Gaspar, Rita; Nunes, Sara; Baptista, Filipa. "Impact of an early primary immune challenge on the retinal dysfunction upon a secondary chronic diabetic insult.". Paper presented in XVII Meeting of the Portuguese Society for Neurosciencce, 2021.
  6. Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Madeira, Maria; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Retinal physiology and function in control and ADHD conditions with(out) methylphenidate treatment". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  7. António Francisco Ambrósio; Alexandra F. Cruz; Boia, Raquel; Gaspar, Rita; Nunes, Sara; Baptista, FI. "Impact of an Early Immune Challenge on the Retinal Dysfunction upon a Secondary Chronic Diabetic Insult". Paper presented in XVII Reunião da Sociedade Portuguesa de Neurociências, 2021.
  8. Santos, Carolina; Pereiro, Xandra; Boia, Raquel; Vecino, Elena; A.F. Ambrosio; Santiago, Ana Raquel. "Microvesicles released by Müller glial cells promote the survival of retinal ganglion cells". Paper presented in V Symposium of the Portuguese Glial Network - Glial cells at the crossroad of health and disease, 2021.
  9. Ferreira-Rodrigues, M; Aires ID; Ribeiro-Rodrigues, Teresa M; Boia, Raquel; Girao, Henrique; António Francisco Ambrósio; Santiago, Ana Raquel. "Intravitreal injection of microglia-derived microvesicles induces retinal inflammation and retinal ganglion cell loss". Paper presented in 3rd Symposium on Physiology & Pathology of Neuroglia, 2020.
  10. Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Martins, Joao; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins, PhD. "Impact of Methylphenidate on the Retina in Control and ADHD conditions". Paper presented in SPF Meeting 2020 - Sociedade Portuguesa de Farmacologia (Portuguese Society of Pharmacology), 2020.
  11. Santos, Carolina; Boia, Raquel; Aires, Inês Dinis; Ambrósio, A.F.; Santiago, Ana Raquel. "The adenosine A3 receptor agonist is protective to the retinas of diabetic mice". Paper presented in IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
  12. Ferreira-Silva, Joana; Boia, Raquel; Aires, Inês Dinis; Martins, Joana Margarida ; Ambrósio, A.F.; Santiago, AR. "Activation of A3 receptors prevents microglial reactivity triggered by elevated hydrostatic pressure". Paper presented in III Symposium of the Portuguese Glial Network, 2019.
  13. Silva, Ana Paula; Madeira, Maria H.; Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Boia, Raquel; Fontes-Ribeiro, Carlos A.; Fernandes, Rosa. "An eye on ADHD: Can the retina be used as a diagnostic support tool?". Paper presented in 7th World Congress on ADHD, 2019.
  14. Boia, Raquel; Martins, Joana Margarida ; Dias, Paulo A N; Galindo-Romero, C; Vidal-Sanz, M.; AGUDO-BARRIUSO, MARTA; C. de Sousa, Hermínio; et al. "Safety of a new biodegradable poly(e-caprolactone) implant to the retina of Wistar rats". Paper presented in XXIII Biennial Meeting of the International Society for Eye Research, 2018.
  15. Santos, Carolina; Boia, Raquel; Aires, Inês Dinis; Ambrósio, A.F.; Santiago, Ana Raquel. "Effect of adenosine A3 receptor agonist treatment in microglial reactivity in a mouse model of diabetic retinopathy". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  16. Martins, Joana Margarida ; Boia, Raquel; Ambrósio, A.F.; Santiago, AR. "Activation of adenosine A3 receptor prevents pressure-induced retinal neuronal cell death.". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, 2017.
  17. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Müller, Christa E.; Cunha, Rodrigo A.; Ambrósio, António Francisco; Ana Raquel Santiago. "Caffeine and the selective A2AR antagonist KW6002 afford protection and control neuroinflammation in a model of transient retinal ischemia". Paper presented in VII Annual Meeting of IBILI, 2015.
  18. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago. "Antagonism of adenosine A2A receptor prevents retinal ganglion cell loss and neuroinflammation in a model of transient retinal ischemia". Paper presented in 6th Annual Alliance for Healthy Aging, 2015.
  19. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago; Queiroz-Gonçalves, F.; Cunha, Rodrigo A.. "Blockade of adenosine A2A receptor prevents retinal ganglion cell loss through the control of neuroinflammation: possible role in glaucoma". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  20. Ana Raquel Santiago; Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Cunha, Rodrigo A.; Ambrósio, António Francisco. "The blockade of adenosine A2A receptor inhibits retinal neuroinflammation and cell death". Paper presented in VI Annual Meeting of IBILI, 2014.
  21. Aires, I; Boia, Raquel; Madeira, Maria Helena Bica; Ambrósio, António Francisco; Ana Raquel Santiago. "A2A receptor blockade prevents pressure-induced microglia reactivity". Paper presented in VI Annual Meeting of IBILI, 2014.
  22. Ambrósio, António Francisco; Elvas, F; Correia, S.R.; Madeira, Maria Helena Bica; Martins, João; Martins, T; Boia, Raquel; Cavadas, C; Ana Raquel Santiago. "Modulation of pro-inflammatory responses in the retina by Neuropeptide Y: the role of NPY Y1 receptor". Paper presented in XXI Biennial Meeting of the International Society for Eye Research, 2014.
  23. Ana Raquel Santiago; Boia, Raquel; Tralhão, P.; Elvas, Filipe; Madeira, Maria Helena Bica; Ambrósio, António Francisco. "Adenosine A2A receptor blockade and caffeine modulate retinal neuroinflammation following ischemia-reperfusion injury". Paper presented in XXI Biennial Meeting of the International Society for Eye Research, 2014.
  24. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Tralhão, P.; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago. "Adenosine A2A receptor blockade and caffeine prevent retinal neuroinflammation and retinal ganglion cell death". Paper presented in The international Symposium on ocular pharmacology and therapeutics, 2014.
  25. Madeira, Maria Helena Bica; Boia, Raquel; Elvas, Filipe; Ambrósio, António Francisco; Ana Raquel Santiago. "Adenosine A2A receptor blockade controls retinal neuroinflammation in experimental models of glaucoma". Paper presented in Microglia: Guardians of the Brain, 2014.
  26. Correia, S.R.; Martins, João; Boia, Raquel; Madeira, Maria Helena Bica; Ana Raquel Santiago; Ambrósio, António Francisco. "Modulation of pro-inflammatory responses in the retina by sitagliptin and the role of neuropeptide Y1 receptor". 2014.
  27. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Szabo, E.; Tomé, A; Ambrósio, António Francisco; Ana Raquel Santiago. "Chronic caffeine administration prevents retinal neuroinflammation and cell death in a rat retinal ischemia-reperfusion model". 2014.
  28. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Tomé, A; Ambrósio, António Francisco; Ana Raquel Santiago; Szabo, E.; Tomé, A.. "Caffeine inhibits neuroinflammation and cell death in the retina induced by ischemia-reperfusion injury". Paper presented in EMBO - Young Scientist Forum, 2013.
Journal article
  1. Cabrera-Maqueda, José María; Boia, Raquel; Lucas-Ruiz, Fernando; González-Riquelme, María José; Ambrósio, António Francisco; Santiago, Ana Raquel; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Galindo-Romero, Caridad. "Neuroinflammation and gliosis in the injured and contralateral retinas after unilateral optic nerve crush". Experimental Eye Research 235 (2023): 109627. http://dx.doi.org/10.1016/j.exer.2023.109627.
    10.1016/j.exer.2023.109627
  2. Realinho, Ana M.; Boia, Raquel; Paiva, Beatriz; Correia, Raquel G.; Gaspar, Rita; Ambrósio, António F.; Baptista, Filipa I.. "Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy". Life Sciences 327 (2023): 121852. http://dx.doi.org/10.1016/j.lfs.2023.121852.
    10.1016/j.lfs.2023.121852
  3. Sanches, Eliane Swely; Boia, Raquel; Silva, Ana Paula; Leitão, Ricardo Alexandre; Medeiros, Maria; Md; Sanches, Eliane S.; et al. "Attention-Deficit/Hyperactivity Disorder animal model presents retinal alterations and methylphenidate has a differential effect in ADHD versus control conditions (under revision)". Antioxidants 12 4 (2023): 937. http://dx.doi.org/10.3390/antiox12040937.
    Under revision • 10.3390/antiox12040937
  4. María José González-Riquelme; Fernando Lucas-Ruiz; Caridad Galindo-Romero; Raquel Boia; António Francisco Ambrósio; Manuel Vidal-Sanz; Ana Raquel Santiago; Marta Agudo-Barriuso. "Comparative Analysis of Retinal Organotypic Cultures and In Vivo Axotomized Retinas". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043481.
    10.3390/ijms24043481
  5. Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Ferreira, Hugo; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage". Journal of Controlled Release 343 (2022): 469-481. http://dx.doi.org/10.1016/j.jconrel.2022.02.001.
    10.1016/j.jconrel.2022.02.001
  6. Riquelme, Maria Josefa Gonzalez; Lucas-Ruiz, Fernando; Boia, Raquel; Santiago, Ana Raquel; Vidal-Sanz, Manuel; Galindo-Romero, Caridad; Agudo-Barriuso, Marta. "Course of retinal ganglion cell loss and microglial activation in two models of neuronal degeneration". Acta Ophthalmologica (2022): https://publons.com/wos-op/publon/54356176/.
    10.1111/J.1755-3768.2022.211
  7. Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Ferreira-Rodrigues, Magda; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules 11 6 (2021): 770. http://dx.doi.org/10.3390/biom11060770.
    10.3390/biom11060770
  8. Ferreira-Silva, Joana; Aires, Inês D.; Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel. "Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure". International Journal of Molecular Sciences 21 19 (2020): 7218. http://dx.doi.org/10.3390/ijms21197218.
    10.3390/ijms21197218
  9. Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells". Glia 68 12 (2020): 2705-2724. http://dx.doi.org/10.1002/glia.23880.
    10.1002/glia.23880
  10. Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Aires, Inês D.; Agudo-Barriuso, Marta; Ambrósio, António Francisco; Vidal-Sanz, Manuel; Santiago, Ana Raquel. "Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension". Cell Death & Disease 11 5 (2020): http://dx.doi.org/10.1038/s41419-020-2593-y.
    10.1038/s41419-020-2593-y
  11. Boia, Raquel; Ruzafa, Noelia; Aires, Inês Dinis; Pereiro, Xandra; Ambrósio, António Francisco; Vecino, Elena; Santiago, Ana Raquel. "Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead". International Journal of Molecular Sciences 21 7 (2020): 2262. http://dx.doi.org/10.3390/ijms21072262.
    10.3390/ijms21072262
  12. Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Catarina; Santos, Paulo Fernando; Ambrósio, António Francisco. "Keep an eye on adenosine: Its role in retinal inflammation". Pharmacology & Therapeutics (2020): 107513. http://dx.doi.org/10.1016/j.pharmthera.2020.107513.
    10.1016/j.pharmthera.2020.107513
  13. Boia, Raquel; Dias, Paulo A.N.; Martins, Joana M.; Galindo-Romero, Caridad; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Porous poly(e-caprolactone) implants: A novel strategy for efficient intraocular drug delivery". Journal of Controlled Release 316 (2019): 331-348. http://dx.doi.org/10.1016/j.jconrel.2019.09.023.
    10.1016/j.jconrel.2019.09.023
  14. Aires, Inês Dinis; Madeira, Maria Helena; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Martins, Joana Margarida; Ambrósio, António Francisco; Santiago, Ana Raquel. "Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-53627-y.
    10.1038/s41598-019-53627-y
  15. Aires, Inês Dinis; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Madeira, Maria Helena; Marques, Carla; Ambrósio, António Francisco; Santiago, Ana Raquel. "Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells". Glia 67 5 (2019): 896-914. http://dx.doi.org/10.1002/glia.23579.
    10.1002/glia.23579
  16. Santiago, Ana Raquel; Aires, Ines Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Almeida, Daniela; Girao, Henrique; Ambrosio, Antonio F.. "Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28332477/.
  17. Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Agudo-Barriuso, Marta; Ambrosio, Antonio F.; Vidal-Sanz, Manuel; Raquel Santiago, Ana. "Adenosine A3 receptor agonist prevents the loss of retinal ganglion cells in a glaucoma model". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28944127/.
  18. Santiago, Ana R.; Boia, Raquel; Aires, Inês D.; Ambrósio, António F.; Fernandes, Rosa. "Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00820.
    10.3389/fphys.2018.00820
  19. Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; et al. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
    10.3389/fphar.2018.00016
  20. Alves, Mariana R. P.; Boia, Raquel; Campos, Elisa J.; Martins, Joao; Nunes, Sara; Madeira, Maria H.; Santiago, Ana Raquel; et al. "Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes". Molecular Vision 24 (2018): 353-366. https://publons.com/wos-op/publon/7412815/.
  21. Boia, Raquel; Elvas, Filipe; Madeira, Maria H; Aires, Inês D; Rodrigues-Neves, Ana C; Tralhão, Pedro; Szabó, Eszter C; et al. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death & Disease 8 10 (2017): e3065-e3065. http://dx.doi.org/10.1038/cddis.2017.451.
    10.1038/cddis.2017.451
  22. Boia, Raquel. "Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases.". Mediators of inflammation (2017): http://europepmc.org/abstract/med/28250576.
    10.1155/2017/4761081
  23. Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel. "Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury". Translational Research 169 (2016): 112-128. http://dx.doi.org/10.1016/j.trsl.2015.11.005.
    10.1016/j.trsl.2015.11.005
  24. Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel. "Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases". Ophthalmic Research 55 4 (2016): 212-218. http://dx.doi.org/10.1159/000443893.
    10.1159/000443893
  25. Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel. "Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure". Journal of Neuroinflammation 12 1 (2015): http://dx.doi.org/10.1186/s12974-015-0333-5.
    10.1186/s12974-015-0333-5
  26. Madeira, Maria H.; Boia, Raquel; Santos, Paulo F.; Ambrósio, António F.; Santiago, Ana R.. "Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases". Mediators of Inflammation 2015 (2015): 1-15. http://dx.doi.org/10.1155/2015/673090.
    10.1155/2015/673090
Thesis / Dissertation
  1. "Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma.". PhD, Universidade de Coimbra, 2020. https://estudogeral.uc.pt/handle/10316/98625.
  2. "Modulation of pro-inflammatory response of retina by adenosinergic system - Neuroinflammation/Neuroprotection.". Master, Universidade de Coimbra, 2013. https://estudogeral.sib.uc.pt/handle/10316/24659.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/18 Invited Speaker - A new therapeutic approach to leverage vision restoration in glaucoma”. DVC.Talks
(Coimbra, Portugal)
2023/10 Small extracellular vesicles derived from reactive microglia contribute to retinal neuroinflammation and neurodegeneration 26th EVER congress
(Valencia, Spain)
2023/06/21 Invited Speaker - “A new therapeutic approach to leverage vision restoration in glaucoma”. Instituto de Medicina Molecular João Lobo Antunes (iMM)
(Lisboa, Portugal)
2023/06 Non-canonical anti-inflammatory effects of sitagliptin on (retinal) microglia. 33rd Conference of the European Association for the Study of Diabetes Eye Complications
(Coimbra, Portugal)
2023/03 Alterações estruturais e funcionais na retina induzidas pela diabetes durante a gravidez nos descendentes durante a infância: diferente vulnerabilidade associada ao sexo. 19º Congresso Português de Diabetes (SPD)
(Vilamoura, Portugal)
2022/12 Glial response in the injured and contralateral retinas after unilateral optic nerve crush. Optic Nerve Meeting
(Obergurgl, Austria)
2021/06 Morphological Changes of Microglial Cells: Comparison between Retinal Organotypic Cultures and In vivo Axotomized Retinas SIREV Congress
(Murcia, Spain)
2021/06 Brain Inflammatory Response after an Unilateral Optic Nerve Damage in Mice. Retinal Organotypic Cultures and In vivo Axotomized Retinas. SIREV Congress
(Murcia, Spain)
2021/02 Intraocular biodegradable implants loaded with adenosine A3 receptor agonist afford protection to retinal ganglion cells 51.ª Reunião da Sociedade Portuguesa de Farmacologia
(Portugal)
2021/02 Impact of methylphenidate on the retina in control and ADHD conditions. 51.ª Reunião da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2021/01/21 Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant 3rd SPLC-CRS Young Scientists Meeting (virtual)
2021/01/20 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma CIBB Neuroscience and Disease - data club
(Portugal)
2021/01/13 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma iCBR scientific meeting
(Portugal)
2020/11 Intravitreal injection of microglia-derived microvesicles induces retinal inflammation and retinal ganglion cell loss. 3rd Symposium on Physiology and Pathology of Neuroglia
2020/10 Resident retinal microglia amplify the neuroinflammatory response initiated by exosomes derived from reactive microglia. PhDOC retreat annual meeting 2020 (online)
2020/02/07 Intraocular biodegradable implant loaded with adenosine A3 receptor agonist as a strategy for the treatment of glaucoma 50.ª Reunião da Sociedade Portuguesa de Farmacologia
(Portugal)
2019/12 Invited Speaker - Long-lasting retinal neuroprotection using an intraocular implant with adenosine A3 receptor agonist CIBB annual meeting 2019
(Coimbra, Portugal)
2019/11 Biodegradable intraocular implant loaded with adenosine A3 receptor agonist affords protection against retinal ischemic injury. 15th ISOPT Clinical: The International Symposium on Ocular Pharmacology & Therapeutics
(Valencia, Spain)
2019/10 Microglial extracellular vesicles induce glial reactivity and retinal degeneration in glaucomatous conditions. PhDOC retreat annual meeting 2019
(Coimbra, Portugal)
2019/07 Exosomes derived from microglia exposed to elevated pressure code for an inflammatory response: implications for retinal degeneration. XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019/05/29 Controlling microglia-mediated neuroinflammation in retinal diseases: role of adenosine A2A receptors IV Symposium of the Portuguese Glial Network
(Lisbon, Portugal)
2019/05/10 Invited Speaker - Activation of A3 adenosine receptor using intraocular biodegradable implants as a neuroprotective strategy against glaucomatous degeneration. CIBB Neuroscience and Disease – Retreat
(Coimbra, Portugal)
2019/04/27 Adenosine A3 receptor agonist prevents the loss of retinal ganglion cells in a glaucoma model Pan-American Research Day
University of British Columbia (Vancouver, Canada)
2019/04/27 Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity.
(Vancouver, Canada)
2018/10 Microglial response to optic nerve injuries 2018 European Association for Vision and Eye Research Conference (EVER)
(Nice, France)
2018/09 Elevated Hydrostatc Pressure-derived Microglial Extracellular Vesicles Drive Microglia Reactvity: Contributon to Neuroinflammatory Response in Glaucoma Models XXIII Biennial Meeting of the International Society for Eye Research in Belfast (ISER)
(Northern Ireland, United Kingdom)
2017/09 Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases XXthEuropean Association for Vision and Eye Research (EVER)
(Nice, France)
2017/04 Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology. 16th European Meeting on Supercritical Fluids (EMSF)
(Lisboa, Portugal)
2016/12 Treatment with an A2A receptor antagonist reduces neuroinflammation and protects the retina against ischemic damage 13th ISOPT Clinical symposium
(Rome, Italy)
2016/09 The Blockade of Adenosine A2A Receptor Affords Neuroprotection through the Control of Microglia Mediated Neuroinflammation in Experimental Models of Glaucoma. XXII Biennial Meeting of the International Society for Eye Research (ISER)
(Tóquio, Japan)
2016/09 Impact of Elevated Pressure in the Adenosinergic System in Microglia and Retina. XXII Biennial Meeting of the International Society for Eye Research (ISER)
(Tóquio, Japan)
2015/03 Prediabetes does not induce changes in tight junction proteins, neural markers and inflammatory mediators in the rat retina. LIMSC
(Netherlands)
2014/12/11 Adenosine A2A receptor blockade and caffeine modulate neuroinflammation following retinal ischemia-reperfusion injury VI Annual Meeting of IBILI
(Coimbra, Portugal)
2014/06 Adenosine A2A receptor blockade and caffeine prevent retinal neuroinflammation and retinal ganglion cell death. 11th ISOPT clinical
(Reykjavik, Iceland)
2014/03 Role of neuroinflammation in retinal degenerative diseases: microglia as a potential therapeutic target. I Simpósio da Rede Glial Luso-Brasileira
(Rio de Janeiro, Brazil)
2013/09 Adenosine A2A receptor blockade and caffeine decrease retinal neuroinflammation. FENS Featured Regional Meeting
(Praga, Czech Republic)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Unraveling the role of Piezo1 channel activation in elevated pressure-exposed microglia: effect on oxidative stress, proliferation, and antigen presentation
Co-supervisor
 Química Medicinal (Master)
Universidade de Coimbra, Portugal
2023/09 - Current Role of Piezo1 in microglia-mediated neuroinflammation: Dissecting the role of Piezo1 activation in the retina
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra, Portugal
2023/09 - Current Adenosine A3 receptor activation as a strategy for axon regeneration in glaucoma
Supervisor
 Neurociências Molecular e de Translação (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09 - 2023/10/23 Role of Piezo1 mechanosensitive channel in elevated pressure-induced microglia reactivity
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/03/04 - 2021/06/14 Efeito do agonista do recetor de adenosina A3 no tratamento das alterações induzidas pela Diabetes do tipo 1 na retina
Supervisor of João Pires
2017/09/04 - 2017/09/29 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
Supervisor of Anna-Maria Graubner
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/11 - Current Cycle of seminars "Meet My Science", an event organized by Postdocs@CIBB Representatives, which aims to showcase, once a month, the scientific work carried out at CIBB. (2023/11)
Seminar (Member of the Organising Committee)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/05/10 - 2022/05/31 Organized a seminar series entitled "May is Healthy Vision Month". These 4 seminars aimed at promoting the discussion between basic researchers and clinicians on the challenges of pre-clinical research and its translation to the patients, Online. (2022/05/10 - 2022/05/31)
Seminar (Other)
 Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2019/10/30 - 2019/10/31 Member of the organizing committee of the "VIII Annual PhDOC meeting" (2019/10/30 - 2019/10/31)
Congress (Member of the Organising Committee)
2016/10/14 - 2016/10/15 Member of the organizing committee of the "V Annual PhDOC meeting" (2016/10/14 - 2016/10/15)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019 - Current Visit to the Basic School "Centro Ilda Moreno de Montemor-o-Velho", "Escola de Alvaiázere" and "Agrupamento de Escolas de Anadia" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2019
2019 - Current Coordination, planning and visit to the School "Centro Escolar da Figueira da Foz" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2019
2018 - Current Coordination, planning and visit to the "Basic School of Abadias, Figueira da Foz" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2018
2018 - Current Participation and co-coordination in the activities related with Noite Europeia dos Investigadores - Guerra das cores (European Researchers Night), that took place at the Nucleo Museológico do Mar, Figueira da Foz European Researchers’ Night 2018
2017 - Current Visit to the "Elementary School from Anadia" to participate in the activity "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2017
2017 - Current Participation and co-coordination in the activities related with Noite Europeia dos Investigadores - Uma noite com sentidos (European Researchers Night), that took place at the Nucleo Museológico do Mar, Figueira da Foz European Researchers’ Night 2017

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/07/18 Efeito da ativação do Piezo-1 na imunoreatividade da iNOS em células da microglia.
(Thesis) Main arguer
 Sara Costa (Other)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/06/19 Otimização de técnicas e criação de modelo celular para o estudo do EYS na retinopatia pigmentar
(Thesis) Main arguer
 Sofia Pereira Nunes da Silva (Other)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/10/25 Unravel the role of p-cadherin expression in ovarian cancer cell lines.
(Thesis) Arguer
 Inês Morgado de Sá (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10/03 Alterações epigenéticas desencadeadas pelo stress e depressão materna durante a gravidez.
(Thesis) Main arguer
 Ana Catarina Cerejeira Silva (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/07/22 Alterações Mitocondriais Associadas a Experiências Adversas na Infância e a sua Relação com Patologias Mentais na Vida Adulta
(Thesis) Main arguer
 Alcina de Fátima Gonçalves (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/07/08 Papel da ativação do mecanorrecetor Piezo-1 em células da microglia na neuro-inflamação
(Thesis) Main arguer
 Solange Trindade Castanheira (Other)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/06/23 Estudo das Alterações Histológicas e Funcionais na Retina de Rato Após Elevação Aguda da Pressão Intraocular
(Thesis) Main arguer
 Joana Cláudia Ferreira da Silva (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Association member

Society Organization name Role
2014 - Current Sociedade Portuguesa de Bioquímica
2013 - Current Sociedade Portuguesa de Neurociências

Committee member

Activity description
Role 		Institution / Organization
2023/11 - Current Postdocs@CIBB Representatives
Member
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/01 - Current Member of science communication project "Fala-me Neuro" which is committed to communicate neuroscience in Portuguese to the society.
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/11/02 - 2021/11/03 Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant Master in Biomedical Research Faculty of Medicine of University of Coimbra, Portugal
2021/03/04 - 2021/06/14 Laboratorial tutor of Applied Research IV Integrated Master in Medicine Universidade de Coimbra, Portugal
2019/02/25 - 2019/03/01 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2018/03/12 - 2018/03/16 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2017/09/26 - 2017/10/06 Laboratorial tutor of the Course of Sciences in Laboratory Animals - Modules 21 and 22 (practice) Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2017/03/06 - 2017/03/10 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2016/02/29 - 2016/03/04 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2015/03/09 - 2015/03/13 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2022/01/24 - Current Special issue "Molecular and cellular players of axonal regeneration in injured CNS" (1662-453X) Frontiers in Neurosciences
2022 - Current Molecular Neurobiology Springer
2021/11/25 - Current Special issue "The Senescence of The Retina" (1662-5129) Frontiers in Neuroanatomy
2021 - Current Acta Biomaterialia Elsevier
2021 - Current Cells MDPI
2021 - Current Drug Design, Development and Therapy Dove Medical Press
2021 - Current Journal of Clinical Medicine MDPI
2021 - Current Journal of Ophthalmology Hindawi
2020 - Current Special Issue "Retinal Neurodegenerative Diseases: Molecular Targets Driving Neuroinflammation and Neuroprotection" (ISSN 1422-0067) MDPI AG
2020 - Current International Journal of Molecular Sciences MDPI
2019 - Current Biomedicine Hub Karger

Mentoring / Tutoring

Topic Student name
2019/01 - 2019/04 PhD student (collaboration in laboratorial supervision during his stay in Portugal) José María Cabrera Maqueda
2018/03/20 - 2018/04/13 PhD student (collaboration in laboratorial supervision during her laboratorial rotation) Daniela Antunes
2017/06 - 2017/09 PhD students (collaboration in laboratorial supervision during his stay in Portugal) Fernando Lucas Ruiz
2016/11 - 2016/12 PhD students (collaboration in laboratorial supervision during her laboratorial rotation) Gabriela Silva
2016/08 - 2016/09 Post-doctoral work (collaboration in laboratorial supervision during her stay in Portugal) Caridad Galindo Romero
Distinctions

Award

2021 Best Oral Communication
3rd SPLC-CRS Young Scientists Meeting, Spain
2014 Best poster
Sociedade Portuguesa de Bioquímica, Portugal

Other distinction

2021 IAPB Eye Health Hero - Innovators category
IAPB Eye Health Hero Programme 2021, United Kingdom