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Sara Filipa Castro da Costa Pinto. Concluiu o(a) Mestrado em Ciências Biofarmacêuticas em 2016/11/23 pelo(a) Universidade de Lisboa Faculdade de Farmácia e Licenciatura em Biologia Celular e Molecular em 2014/06/18 pelo(a) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Frequenta o(a) Doutoramento em Ciências Biomédicas pelo(a) Universidade de Lisboa Faculdade de Medicina desde 2019/10. É Investigador no(a) Instituto de Medicina Molecular. Publicou 8 artigos em revistas especializadas. Possui 1 livro(s). Participou em 9 evento(s). Recebeu 1 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Doutoramento em 1 projeto(s) e Bolseiro de Investigação em 1 projeto(s). Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular e Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências. Nas suas atividades profissionais interagiu com 56 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: amyotrophic lateral sclerosis; microglia polarization; microglia surface receptors; inflamma-microRNA; motor neurons; exosomes; mutant SOD1; Amyotrophic Lateral Sclerosis; mutant SOD1G93A; Microglia Reactivity; Inflammatory-associated microRNAs; Glycoursodeoxycholic acid; Vinyl sulfone; Alzheimer's disease; iPSC; neuroinflammation; extracellular vesicles; .
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Identification

Personal identification

Full name
Sara Filipa Castro da Costa Pinto

Citation names

  • Costa-Pinto, Sara

Author identifiers

Ciência ID
B81D-4126-B667
ORCID iD
0000-0002-9785-8956

Email addresses

  • sfccpinto@gmail.com (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2019/10 - 2023/10
Ongoing
 Ciências Biomédicas (Doutoramento)
Major in Neurociências
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/05 - 2023/07
Concluded
 Clinical Research and Project Management (Diploma de especialização)
Invictus Sciences, Portugal
2019/11
Concluded
 Course on Laboratory Animal Science for Function A (former FELASA Category B) (Diploma de especialização)
Direcção-Geral de Alimentação e Veterinária, Portugal
2014/10/01 - 2016/11/23
Concluded
 Ciências Biofarmacêuticas (Mestrado)
Major in Neurobiologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
"ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction" (THESIS/DISSERTATION)
 18
2011 - 2014/06/18
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2019/10/01 - Current Researcher (Research) Instituto de Medicina Molecular, Portugal
2017/02/01 - 2019/02/01 Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2015/09 - 2017/01 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/01 - 2014/02 Research Trainee (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Projects

Grant

Designation Funders
2024/03/07 - 2024/07/06 Does the context matter for drug action? Context dependency of the long-lasting neurobiological and antidepressant actions of psilocybin
PTDC/MED-FAR/4834/2021
Research Fellow
Ongoing
2019/10 - 2024/02/29 Astrosomes: Artificial Astrocytes as a Novel Therapeutic to Amyotrophic Lateral Sclerosis (ALS)
SFRH/BD/147277/2019
PhD Student Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2017/02/01 - 2019/02/01 Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease
info:eu-repo/grantAgreement/AKA/301253/FI
Research Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
Outputs

Publications

Book
  1. Vaz, Sandra H; Pinto, Sara; Sebastião, Ana M.; Brites, Dora. Amyotrophic Lateral Sclerosis. Brisbane, Australia: Exon Publications. 2021.
    Published • 10.36255/exonpublications.amyotrophiclateralsclerosis.2021
Conference poster
  1. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Tedim-Moreira, Joana; Socodato, Renato; Relvas, Joao B; Sebastião, AM; Vaz, Sandra H. "When your support cells aren't that supportive: astrocytic alterations contribute to early impairments in the motor cortex plasticity of presymptomatic SOD1G93A mice". Paper presented in FENS Forum 2024, 2024.
  2. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Tedim-Moreira, Joana; Socodato, Renato; Relvas, João B.; Sebastião, Ana M.; Vaz, Sandra H. "Lack of astrocytic support contributes to early impairments in the motor cortex plasticity of presymptomatic SOD1G93A mice". Paper presented in VIII Symposium Portuguese Glial Network 2024, 2024.
  3. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Tedim-Moreira, Joana; Socodato, Renato; Relvas, JB; Sebastião, AM; Vaz SH. "Early impairments in primary motor cortex transmission and plasticity of SOD1G93A mice". Paper presented in FENS Regional Meeting, 2023.
  4. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Sebastião, AM; Vaz SH. "Unveiling the astrocytic contribution for synaptic dysfunction in ALS". Paper presented in ISN-APSN 2022 Meeting, 2022.
  5. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Sebastião, AM; Vaz SH. "Astrocytic impact in synaptic plasticity and transmission deficits in SOD1G93A mice". Paper presented in FENS Forum 2022, 2022.
  6. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Sebastião, AM; Vaz SH. "Astrocytic contribution for synaptic plasticity and transmission defects in SOD1G93A mice". Paper presented in XV CAML·V NeurULisboa PhD Students Meeting, 2022.
  7. Costa-Pinto, Sara. "Astrocytic dysfunction is a key player in synaptic plasticity and transmission deficits in SOD1G93A mice". Paper presented in V Symposium Portuguese Glial Network 2021, 2021.
  8. Pinto, Sara. "Overexpression of wild-type and mutant SOD1 in N9 microglia upon steady-state, inflammatory and immunomodulatory conditions leads to distinct phenotypes". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  9. Pinto, Sara. "iPSCS-derived astrocytes with the PSEN1E¿9 mutation show aberrant activation and dysregulated exosomal cargo in small non-coding RNAs after A1 stimulation". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  10. Pinto, Sara; Ezequiel, Catarina; Cunha, Carolina; Carvalho, Luís A.; Moreira, Rui; Vaz, Ana R.; Brites, Dora. "N9 microglia activation in the course of overexpressed human mutated SOD1G93A is mitigated by dipeptidyl vinyl sulfone". Paper presented in 4th Meeting of the PhD students from the Mind-Brain College of the University of Lisbon, 2018.
  11. Ferreira, Sofia; Pinto, Sara; Garcia, Gonçalo; Moreira, Filipa; Oksanen, Minna; Koistinaho, Jari ; Fernandes, Adelaide; Brites, Dora. "Microglial-derived cytokines trigger morphological and inflammatory aberrancies together with an altered exosomal cargo in human astrocytes generated from AD-iPSCs". Paper presented in 4th Meeting of the PhD students from the Mind-Brain College of the University of Lisbon, 2018.
  12. Garcia, Gonçalo; Cunha, Mariana; Pinto, Sara; Moreira, Filipa; Ferreira, Sofia; Fernandes, Adelaide; Brites, Dora. "APP-Swe cells overexpress miR-124 as a protective mechanism to maintain their morphology and reduce exosomal inflammatory-miRNA cargo". Paper presented in 4th Meeting of the PhD students from the Mind-Brain College of the University of Lisbon, 2018.
  13. Pinto, Sara; Ribeiro, Ana; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; Puttonen, K; et al. "iPSCs-derived astrocytes as a model to uncover pathological mechanisms in Alzheimer’s disease patients". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting and 3rd i3DU Meeting, 2018.
  14. Ferreira, Sofia; Moreira, Filipa; Pinto, Sara; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; et al. "A1 stimulation induces alterations in morphology, miRNA profile and exosomal cargo of iPSCs-derived astrocytes from Alzheimer’s disease patients". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting and 3rd i3DU Meeting, 2018.
  15. Garcia, Gonçalo; Cunha, Mariana; Pinto, Sara; Moreira, Filipa; Ferreira, Sofia; Fernandes, Adelaide; Brites, Dora. "miR-124 regulates neuronal morphology and neurite outgrowth, while is associated to inflammatory-miRNA signature in SH/SWE cells and their exosomes". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting and 3rd i3DU Meeting, 2018.
  16. Pinto, Sara; Ribeiro, Ana; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; Puttonen, K; et al. "Human iPSC-derived neurons and astrocytes as models of neurodegeneration, neuroinflammation and vesicular trafficking in Alzheimer’s disease". Paper presented in 19th Meeting of the International Society for Free Radical Research (SFRRI), 2018.
  17. Pinto, Sara; Ribeiro, Ana; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; Puttonen, K; et al. "Human iPSC-derived astrocytes from Alzheimer’s disease patients: a model to study disease pathogenesis and vesicular trafficking". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  18. Ferreira, Sofia; Moreira, Filipa; Pinto, Sara; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; et al. "iPSCs-derived astrocytes from Alzheimer’s disease patients alter their morphology, miRNA profile and exosomal cargo when activated". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  19. Garcia, Gonçalo; Cunha, Mariana; Pinto, Sara; Moreira, Filipa; Ferreira, Sofia; Fernandes, Adelaide; Brites, Dora. "Inhibition of miR-124 causes neuronal morphological changes and distinct patterns of miR-21 and miR-146a in SH-APPSwe cells and their exosomes". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  20. Pinto, Sara; Ribeiro, Ana; Cunha, Carolina; Vaz, Ana R.; Oksanen, Minna; Peterson, AJ; Puttonen, K; et al. "Astrocytes derived from iPSCs of Alzheimer’s patients show a downregulated RAGE/miR-155 pathway and alterations in the molecular content of extracellular vesicles". Paper presented in 3rd Meeting of the PhD students from the Mind-Brain College of the University of Lisbon, 2017.
  21. Pinto, Sara; Barbosa, Marta; Cunha, Carolina; Vaz, Ana R.; Brites, Dora. "Mutant SOD1 motor neuron-derived exosomes trigger microglia activation and dysfunction". Paper presented in 2nd Meeting of the PhD students from the Mind-Brain College of the University of Lisbon, 2016.
  22. Pinto, Sara; Barbosa, Marta; Cunha, Carolina; Brites, Dora. "Extracellular vesicles from ALS motor-neurons trigger microglia activation". Paper presented in 8th iMed.ULisboa Postgraduate Students Meeting, 2016.
Journal article
  1. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Tedim-Moreira, Joana; Socodato, Renato; Relvas, João B.; Sebastião, Ana M.; Vaz, Sandra H.. "Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice". Neurobiology of Disease 193 (2024): 106435. http://dx.doi.org/10.1016/j.nbd.2024.106435.
    Published • 10.1016/j.nbd.2024.106435
  2. Gonçalves-Ribeiro, Joana; Savchak, Oksana K.; Costa-Pinto, Sara; Gomes, Joana I.; Rivas-Santisteban, Rafael; Lillo, Alejandro; Sánchez Romero, Javier; et al. "Adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex". Glia 72 6 (2024): 1096-1116. http://dx.doi.org/10.1002/glia.24518.
    Published • 10.1002/glia.24518
  3. Garcia, Gonçalo; Costa-Pinto, Sara; Ferreira, Sofia; Lopes, Daniela; Serrador, Maria João; Fernandes, Adelaide; Vaz, Ana Rita; et al. "Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease". Cells 11 21 (2022): 3377. http://dx.doi.org/10.3390/cells11213377.
    10.3390/cells11213377
  4. Garcia, Gonçalo; Pinto, Sara; Cunha, Mar; Fernandes, Adelaide; Koistinaho, Jari; Brites, Dora. "Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor". Cells 10 9 (2021): 2424. http://dx.doi.org/10.3390/cells10092424.
    10.3390/cells10092424
  5. Armada-Moreira, Adam; Gomes, Joana I.; Pina, Carolina Campos; Savchak, Oksana K.; Gonçalves-Ribeiro, Joana; Rei, Nádia; Pinto, Sara; et al. "Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00090.
    10.3389/fncel.2020.00090
  6. Vaz, Ana Rita; Pinto, Sara; Ezequiel, Catarina; Cunha, Carolina; Carvalho, Luís A.; Moreira, Rui; Brites, Dora. "Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00109.
    Published • 10.3389/fncel.2019.00109
  7. Pinto, Sara. "A1 polarized IPSCs-derived astrocytes with the PSEN1E¿9 mutation show deregulated inflammatory dynamics". Frontiers in Cellular Neuroscience (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00025.
    10.3389/conf.fncel.2019.01.00025
  8. Pinto, Sara; Cunha, Carolina; Barbosa, Marta; Vaz, Ana R.; Brites, Dora. "Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype". Frontiers in Neuroscience 11 (2017): 273. http://dx.doi.org/10.3389/fnins.2017.00273.
    Published • 10.3389/fnins.2017.00273
Thesis / Dissertation
  1. Pinto, Sara. "ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction". Master, Universidade de Lisboa Faculdade de Farmácia, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/11/20 When your support cells are not supportive: Astrocytic changes contribute to synaptic dysfunction in the SOD1G93A mice Iberian Glial Networks Symposium
2023/05 Role of astrocytes on the abnormal synaptic transmission and plasticity in the motor cortex and hippocampus of SOD1G93A mice VII Symposium Portuguese Glial Network 2023
(Albufeira, Portugal)
2023/05 Role of astrocytes on synaptic transmission and plasticity in the motor cortex and hippocampus of SOD1G93A mice XVI CAML PhD Students Meeting
(Lisboa, Portugal)
2022/07 The link between astrocytes and synaptic dysfunction Workshop in Innovative Models and Therapies for Amyotrophic Lateral Sclerosis
(Lisboa, Portugal)
2022/06 Unveiling the astrocytic contribution for synaptic dysfunction in ALS Summer school in Optogenetics, Chemogenetics, CRISPR and epilepsy models
(Lund, Sweden)
2021/05 Unveiling the mechanisms of astrocytic dysfunction in ALS XIV CAML · IV NeurULisboa PhD Students Virtual Meeting
2021/02/19 Role of astrocytes in hippocampal synaptic dysfunction in ALS Annual Meeting of Pharmacology Portuguese Society
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2021/02/19 Vesicle dissemination of neuronal TrKB-ICD in secretome: relevance for Alzheimer's Disease pathophysiology Annual Meeting of Pharmacology Portuguese Society.
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2021/02/18 Mechanism of astrocyte for neurotoxicity of amyloid-ß: implication of D-serine Annual Meeting of Pharmacology Portuguese Society.
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2021/02 Role of astrocytes in hippocampal synaptic dysfunction in ALS 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology
2019/03/26 Morphological and inflammatory aberrancies in homogeneous and heterogeneous populations of human astrocytes generated from AD-iPSCs and consequences in exosomal cargo 14th International Conference on Alzheimer's and Parkinson's Diseases
(Lisboa, Portugal)
2019/03/26 Overexpression of miR-124 in APP-Swe cells is a protective mechanism to maintain their morphology and reduce exosomal inflammatory-miRNA cargo 14th International Conference on Alzheimer's and Parkinson's Diseases
(Lisboa, Portugal)
2018/11/14 N9 microglia activation in the course of overexpressed human mutated SOD1G93A is mitigated by dipeptidyl vinyl sulfone 4th Meeting of the PhD students from the Mind-Brain College of the University of Lisbon
(Lisboa, Portugal)
2017/10 iPSCs-derived astrocytes from patients with PSEN1¿E9 mutation show a depressed RAGE/miR-155 pathway with impact in extracellular vesicle molecular cargo 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
(Covilhã, Portugal)
2016/06/03 Exosomes as mediators of neuroinflammation and pathogenicity in ALS 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/01 - 2023/06/02 Workshop in Use of human epileptic tissue from epilepsy surgeries as a validation step of findings in animal models by Epileptogenesis and Epilepsy Network
Workshop
 Use of human epileptic tissue from epilepsy surgeries as a validation step of findings in animal models
Lunds Universitet, Sweden
2023/02 - 2023/02 Round table participation in the workshop Master in Biopharmaceutical Sciences by Faculty of Pharmacy, University of Lisbon.
Round table
 Workshop “Master in Biopharmaceutical Sciences”
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04 - 2021/11 The International Astrocyte School is aimed at all those who are attracted by the most intriguing hypotheses on the role of astrocytes and other glial cells in brain function and dysfunction and wish to learn how to best approach these problems. International Astrocyte School
2021/09/27 - 2021/10/01 Summer School 'Trends and Challenges in Epilepsy Research' by Epileptogenesis and Epilepsy Network
2021/09/24 - 2021/09/24 A Noite Europeia dos Investigadores pretende realçar a importância e o impacto da ciência na sociedade, promover a carreira de cientista junto dos mais jovens e demonstrar em que consiste o dia a dia de um cientista.
Meeting
 Noite Europeia dos Investigadores
2020/03 - 2020/03 Introduction to Data Management Plans by BioData.pt
Workshop
Instituto de Medicina Molecular, Portugal
2020/03 - 2020/03 Graphic Design by Christof De Bo (VIB)
Workshop
Instituto de Medicina Molecular, Portugal
2017/07/24 - 2017/07/28 Ciência Viva program in the laboratory - scientific occupation of young students in holiday’s time.
Other
 Ciência Viva no Laboratório
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/06 - 2016/06 Brain Imaging: an introductory workshop on research and clinical applications
Workshop
Mind-Brain College of the University of Lisbon, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022/09 - 2023/09 Pizza seminars, informal presentations from PhD students to PhD students at IMM
Member
 Instituto de Medicina Molecular, Portugal
2022/01 - 2023/01 Grupo de estudantes de Doutoramento da Faculdade de Medicina da Universidade de Lisboa, responsável por organizar o encontro anual CAML PhD Students Meeting. Este Encontro, que pretende a divulgação e discussão dos projetos científicos desenvolvidos pelos estudantes e conta com a participação da comunidade de investigadores do Instituto de Medicina Molecular João Lobo Antunes (iMM), da Faculdade de Medicina da Universidade de Lisboa (FMUL) e do Hospital de Santa Maria.
Member
 Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal

Mentoring / Tutoring

Topic Student name
2021/03 - 2023/01 Role of BDNF in ALS Mariana Vendeirinho
2021/03 - 2021/11 Functional role of endocannabinoid receptors in Amyotrophic Lateral Sclerosis (ALS) Francisco Mendes
2021/03 - 2021/11 Functional role of endocannabinoid receptors in Amyotrophic Lateral Sclerosis (ALS) Miguel Catarino
Distinctions

Award

2023 Best oral communication in XVI CAML PhD Students Meeting
Universidade de Lisboa Faculdade de Medicina, Portugal