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Steve Howdle has pioneered the use of supercritical CO2 (scCO2) in polymer science, particularly in the development of surfactants; developing novel nanostructured materials; and application in tissue engineering and drug delivery. His work is highly interdisciplinary, spanning the interfaces of chemistry/life sciences, chemistry/materials science and chemistry/engineering. His impact includes high quality publications and commercial applications with achievements including: (i) using scCO2 to encapsulate thermally sensitive pharmaceuticals and even living cells into polymers; (ii) the first use of surfactants to create inverse aqueous micelles in scCO 2 and (iii) demonstration of several different techniques for controlled polymerisation in scCO2 including dispersion, RAFT and enzyme catalysed and (iv) the development of new hierarchical nanostructured materials. He has an h-index of 72 and > 15700 citations; high values for his field and all achieved without publishing lengthy reviews. Steve has played a strong leadership role in the chemistry/polymer community as Chair of the RSC/SCI MacroGroup; founder of the still flourishing RAPS Network (formed in 2000), and as a Council member of the UK’s High Polymer Research Group. He has also contributed as an active member of the EPSRC Physical Sciences SAT and contributed to EPSRC led International Reviews of Chemistry and Chemical Engineering. He is currently the Head of School at Nottingham and is a proactive member of HCUK helping the RSC cope with the pandemic and its effects on both our students and research.
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Identification

Personal identification

Full name
Steven Howdle

Citation names

  • Howdle, Steven

Author identifiers

Ciência ID
B81A-4295-FA54
ORCID iD
0000-0001-5901-8342
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2001 - Current Full Professor (University Teacher) University of Nottingham School of Chemistry, United Kingdom
Projects

Grant

Designation Funders
2021/03 - 2026/02 Sustainable Chemicals Innovations Enabling Net Carbon Emissions (SCIENCE)
EPSRC
Integration into Research Grant Fellow
2022/01 - 2024/03 COtooCLEAN Food Grade Recycled Polyolefins
Innovate UK
Principal investigator
2019/01 - 2023/12 High Resolution, Cryogenic Analytical And Transfer Scanning Electron Microscope (HR-CAT-SEM)
EPSRC
Integration into Research Grant Fellow
2019/09 - 2023/10 Enzyme catalysed polymerisation
BBSRC/ Croda
Principal investigator
2019/10 - 2023/09 Sustainable Raw Materials for Lubricant additives
Lubrizol/ PhD
Principal investigator
2017/10 - 2021/09 Novel Core Shell Polymeric materials
Kaneka Bv/PHd
Principal investigator
2019/11 - 2021/05 Core Equipment award
EPSRC
Integration into Research Grant Fellow
2017/06 - 2020/05 KTP Innovate UK
Cornelius + TSB
Principal investigator
2018/03 - 2020/02 Novel Polymers for Selective Laser Sintering: A New Approach to 3D Printing
Royal Society
Principal investigator
2016/04 - 2019/03 A Novel Route To Peptide Based Drug Delivery Devices (MRC/DTG)
MRC/DTG
Principal investigator
Concluded
2014/10 - 2018/03 Novel Polymers from Terpenes (EPSRC)
EP/N019784/1
Principal investigator
2014/10 - 2018/03 A Clean and Versatile Route to Hierarchical Structured Functional Devices (Leverhulme)
RPG-2014-034
Principal investigator
2015/07 - 2017/07 EPSRC Lowering the Energy Demand and Broadening the Scope of Renewable Polymer Manufacture
EP/M013952/1
Principal investigator
2016/12 - 2017/03 IAA Top Up
EPSRC
Principal investigator
2016/10 - 2017/03 IAA Case Study Development
EPSRC
Principal investigator
2013/09 - 2017/03 Polymeric Microspheres for the Next Generation of Display Devices (EPSRC DTG Merck )
EPSRC DTG Merck
Principal investigator
Outputs

Publications

Journal article
  1. Sagnelli, Domenico; Vestri, Ambra; Curia, Silvio; Taresco, Vincenzo; Santagata, Gabriella; Johansson, Mats K.G.; Howdle, Steven M.. "Green enzymatic synthesis and processing of poly (cis-9,10-epoxy-18-hydroxyoctadecanoic acid) in supercritical carbon dioxide (scCO2)". European Polymer Journal 161 (2021): 110827. http://dx.doi.org/10.1016/j.eurpolymj.2021.110827.
    10.1016/j.eurpolymj.2021.110827
  2. Thomas M. Bennett; Julien Portal; Valérie Jeanne-Rose; Simon Taupin; Alexander Ilchev; Derek J. Irvine; Steven M. Howdle. "Synthesis of model terpene-derived copolymers in supercritical carbon dioxide for cosmetic applications". European Polymer Journal 157 (2021): 110621-110621. https://doi.org/10.1016/j.eurpolymj.2021.110621.
    10.1016/j.eurpolymj.2021.110621
  3. Cutajar, Michelle; Andriulo, Fabrizio; Thomsett, Megan R.; Moore, Jonathan C.; Couturaud, Benoit; Howdle, Steven M.; Stockman, Robert A.; Harding, Stephen E.. "Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-86543-1.
    10.1038/s41598-021-86543-1
  4. Xu, Jinchuan; Sagnelli, Domenico; Faisal, Marwa; Perzon, Alixander; Taresco, Vincenzo; Mais, Marco; Giosafatto, Concetta Valeria L.; et al. "Amylose/cellulose nanofiber composites for all-natural, fully biodegradable and flexible bioplastics". Carbohydrate Polymers 253 (2021): 117277. http://dx.doi.org/10.1016/j.carbpol.2020.117277.
    10.1016/j.carbpol.2020.117277
  5. Kortsen, Kristoffer; Pacheco, Ana A.C.; Lentz, Joachim C; Taresco, Vincenzo; Howdle, Steven M.. "On-line polymerisation monitoring in scCO2: a reliable and inexpensive sampling method in high pressure applications". The Journal of Supercritical Fluids 167 (2021): 105047. http://dx.doi.org/10.1016/j.supflu.2020.105047.
    10.1016/j.supflu.2020.105047
  6. Ana A. C. Pacheco; Arnaldo F. da Silva Filho; Kristoffer Kortsen; Magnus W. D. Hanson-Heine; Vincenzo Taresco; Jonathan D. Hirst; Muriel Lansalot; Franck D'Agosto; Steven M. Howdle. "Influence of structure and solubility of chain transfer agents on the RAFT control of dispersion polymerisation in scCO2". Chemical Science 12 3 (2021): 1016-1030. https://doi.org/10.1039/D0SC05281G.
    10.1039/D0SC05281G
  7. Amy R. Goddard; Edward A. Apebende; Joachim C. Lentz; Kim Carmichael; Vincenzo Taresco; Derek J. Irvine; Steven M. Howdle. "Synthesis of water-soluble surfactants using catalysed condensation polymerisation in green reaction media". Polymer Chemistry (2021): https://doi.org/10.1039/D1PY00415H.
    10.1039/D1PY00415H
  8. Larder, Ryan R.; Bennett, Thomas M.; Blankenship, L. Scott; Fernandes, Jesum A.; Husband, Bethany K.; Atkinson, Rachel L.; Derry, Matthew J.; et al. "Porous hollow TiO2 microparticles for photocatalysis: exploiting novel ABC triblock terpolymer templates synthesised in supercritical CO2". Polymer Chemistry 12 19 (2021): 2904-2913. http://dx.doi.org/10.1039/d1py00334h.
    10.1039/d1py00334h
  9. Atkinson, Rachel L.; Monaghan, Olivia R.; Elsmore, Matthew T.; Topham, Paul D.; Toolan, Daniel T. W.; Derry, Matthew J.; Taresco, Vincenzo; et al. "RAFT polymerisation of renewable terpene (meth)acrylates and the convergent synthesis of methacrylate–acrylate–methacrylate triblock copolymers". Polymer Chemistry 12 21 (2021): 3177-3189. http://dx.doi.org/10.1039/d1py00326g.
    10.1039/d1py00326g
  10. Montanari, Ulisse; Taresco, Vincenzo; Liguori, Anna; Gualandi, Chiara; Howdle, Steven M; Ulisse Montanari; Vincenzo Taresco; et al. "Synthesis of novel carvone (meth)acrylate monomers for the production of hydrophilic polymers with high terpene content". Polymer International 70 5 (2020): 499-505. http://dx.doi.org/10.1002/pi.6096.
    10.1002/pi.6096
  11. Haddleton, Alice J.; Bassett, Simon P.; Howdle, Steven M.. "Comparison of polymeric particles synthesised using scCO2 as the reaction medium on the millilitre and litre scale". The Journal of Supercritical Fluids 160 (2020): 104785. http://dx.doi.org/10.1016/j.supflu.2020.104785.
    10.1016/j.supflu.2020.104785
  12. Englezou, Georgia; Kortsen, Kristoffer; Pacheco, Ana A. C.; Cavanagh, Robert; Lentz, Joachim C.; Krumins, Eduards; Sanders-Velez, Carlos; et al. "2-Methyltetrahydrofuran ( 2-MeTHF ) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP , FRP , and RAFT tandem polymerizations". Journal of Polymer Science 58 11 (2020): 1571-1581. http://dx.doi.org/10.1002/pol.20200183.
    10.1002/pol.20200183
  13. Minaev, N. V.; Mironov, A. V.; Minaeva, S. A.; Mironova, O. A.; Syachina, M. A.; Krumins, E.; Howdle, S.; Popov, V. K.. "An Apparatus for Research on Processes of Selective Laser Sintering of Powder Materials with High Spatial Resolution". Instruments and Experimental Techniques 63 2 (2020): 288-290. http://dx.doi.org/10.1134/s0020441220020116.
    10.1134/s0020441220020116
  14. Vestri, Ambra; Pearce, Amanda K.; Cavanagh, Robert; Styliari, Ioanna D.; Sanders, Carlos; Couturaud, Benoit; Schenone, Silvia; et al. "Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device". Coatings 10 2 (2020): 125. http://dx.doi.org/10.3390/coatings10020125.
    10.3390/coatings10020125
  15. O'Brien, Dara M.; Atkinson, Rachel L.; Cavanagh, Robert; Pacheco, Ana A.C.; Larder, Ryan; Kortsen, Kristoffer; Krumins, Eduards; et al. "A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers". European Polymer Journal 125 (2020): 109516. http://dx.doi.org/10.1016/j.eurpolymj.2020.109516.
    10.1016/j.eurpolymj.2020.109516
  16. Alice J. Haddleton; Thomas M. Bennett; Xinyong Chen; Rachel L. Atkinson; Vincenzo Taresco; Steven M. Howdle; Haddleton, Alice J.; et al. "Synthesis of two-phase polymer particles in supercritical carbon dioxide". Polymer Chemistry 5 29 (2020): 5806-5815. https://doi.org/10.1039/D0PY00729C.
    10.1039/D0PY00729C
  17. Payal Baheti; Timo Rheinberger; Olinda Gimello; Cécile Bouilhac; Frederik R. Wurm; Patrick Lacroix-Desmazes; Steven M. Howdle. "Clean synthesis of linear and star amphiphilic poly(e-caprolactone)-block-poly(ethyl ethylene phosphonate) block copolymers: assessing self-assembly and surface activity". Green Chemistry (2020): https://doi.org/10.1039/D0GC00819B.
    10.1039/D0GC00819B
  18. Mariana d'Almeida Gameiro; Amy Goddard; Vincenzo Taresco; Steven M. Howdle. "Enzymatic one-pot synthesis of renewable and biodegradable surfactants in supercritical carbon dioxide (scCO2)". Green Chemistry (2020): https://doi.org/10.1039/C9GC04011K.
    10.1039/C9GC04011K
  19. Simon P. Bassett; Andrew D. Russell; Paul McKeown; Isabel Robinson; Thomas R. Forder; Vincenzo Taresco; Matthew G. Davidson; Steven M. Howdle. "Low-temperature and purification-free stereocontrolled ring-opening polymerisation of lactide in supercritical carbon dioxide". Green Chemistry (2020): https://doi.org/10.1039/D0GC00352B.
    10.1039/D0GC00352B
  20. Pearce, Amanda K.; Vasey, Catherine E.; Anane-Adjei, Akosua B.; Sodano, Federica; Crucitti, Valentina Cuzzucoli; Irvine, Derek J.; Howdle, Steve M.; Alexander, Cameron; Taresco, Vincenzo. "Versatile, Highly Controlled Synthesis of Hybrid (Meth)acrylate–Polyester–Carbonates and their Exploitation in Tandem Post-Polymerization–Functionalization". Macromolecular Chemistry and Physics 220 21 (2019): 1900270. http://dx.doi.org/10.1002/macp.201900270.
    10.1002/macp.201900270
  21. Sagnelli; Cavanagh; Xu; Swainson; Blennow; Duncan; Taresco; Howdle. "Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials". Coatings 9 8 (2019): 482. http://dx.doi.org/10.3390/coatings9080482.
    10.3390/coatings9080482
  22. Nabil Bensabeh; Adrian Moreno; Adrià Roig; Olivia R. Monaghan; Juan C. Ronda; Virginia Cádiz; Marina Galià; et al. "Polyacrylates Derived from Biobased Ethyl Lactate Solvent via SET-LRP". Biomacromolecules 20 5 (2019): 2135-2147. https://doi.org/10.1021/acs.biomac.9b00435.
    10.1021/acs.biomac.9b00435
  23. Han, Felicity Y.; Whittaker, Andrew; Howdle, Steven M.; Naylor, Andrew; Shabir-Ahmed, Anjumn; Smith, Maree T.. "Sustained-Release Hydromorphone Microparticles Produced by Supercritical Fluid Polymer Encapsulation". Journal of Pharmaceutical Sciences 108 2 (2019): 811-814. http://dx.doi.org/10.1016/j.xphs.2018.09.021.
    10.1016/j.xphs.2018.09.021
  24. Stefan Oelmann; Alessandra Travanut; Dennis Barther; Manuel Romero; Steven M. Howdle; Cameron Alexander; Michael A. R. Meier. "Biocompatible Unimolecular Micelles Obtained via the Passerini Reaction as Versatile Nanocarriers for Potential Medical Applications". Biomacromolecules 20 1 (2019): 90-101. https://doi.org/10.1021/acs.biomac.8b00592.
    10.1021/acs.biomac.8b00592
  25. Guping He; Thomas M. Bennett; Kartini Alias; Long Jiang; Simon T. Schwab; Mohammad Alauhdin; Steven M. Howdle. "In situ crosslinking of nanostructured block copolymer microparticles in supercritical carbon dioxide". Polymer Chemistry 10 29 (2019): 3960-3972. https://doi.org/10.1039/C9PY00556K.
    10.1039/C9PY00556K
  26. Dara M. O’Brien; Cindy Vallieres; Cameron Alexander; Steven M. Howdle; Robert A. Stockman; Simon V. Avery. "Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments". Journal of Materials Chemistry B 7 34 (2019): 5222-5229. https://doi.org/10.1039/C9TB00878K.
    10.1039/C9TB00878K
  27. Thomas D. McAllister; Thomas M. Bennett; Chiara Petrillo; Claire Topping; Louise D. Farrand; Nathan Smith; Steven M. Howdle. "Highly coloured and electrophoretically active polymer microparticles via staggered dispersion polymerisation in supercritical carbon dioxide and dodecane". Journal of Materials Chemistry C (2019): https://doi.org/10.1039/C9TC03558C.
    10.1039/C9TC03558C
  28. Mohammad Alauhdin; Thomas M. Bennett; Guping He; Simon P. Bassett; Giuseppe Portale; Wim Bras; Daniel Hermida-Merino; Steven M. Howdle. "Monitoring morphology evolution within block copolymer microparticles during dispersion polymerisation in supercritical carbon dioxide: a high pressure SAXS study". Polymer Chemistry 10 7 (2019): 860-871. https://doi.org/10.1039/C8PY01578C.
    10.1039/C8PY01578C
  29. Megan R. Thomsett; Jonathan C. Moore; Antoine Buchard; Robert A. Stockman; Steven M. Howdle. "New renewably-sourced polyesters from limonene-derived monomers". Green Chemistry 21 1 (2019): 149-156. https://doi.org/10.1039/C8GC02957A.
    10.1039/C8GC02957A
  30. Rahmet Parilti; Alba Castañon; Muriel Lansalot; Franck D'Agosto; Christine Jérôme; Steven M. Howdle. "Hydrocarbon based stabilisers for the synthesis of cross-linked poly(2-hydroxyethyl methacrylate) particles in supercritical carbon dioxide". Polymer Chemistry (2019): https://doi.org/10.1039/C9PY00998A.
    10.1039/C9PY00998A
  31. Baheti, P.; Bonneaud, C.; Bouilhac, C.; Joly-Duhamel, C.; Howdle, S. M.; Lacroix-Desmazes, P.. "Novel green route towards polyesters-based resin by photopolymerization of star polymers". Express Polymer Letters 13 12 (2019): 1104-1115. http://dx.doi.org/10.3144/expresspolymlett.2019.95.
    10.3144/expresspolymlett.2019.95
  32. Thomas M. Bennett; Guping He; Ryan R. Larder; Michael G. Fischer; Graham A. Rance; Michael W. Fay; Amanda K. Pearce; et al. "Clean Block Copolymer Microparticles from Supercritical CO2: Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides". Nano Letters 18 12 (2018): 7560-7569. https://doi.org/10.1021/acs.nanolett.8b03044.
    10.1021/acs.nanolett.8b03044
  33. Han, Felicity; Whittaker, Andrew; Howdle, Steven; Naylor, Andrew; Shabir-Ahmed, Anjumn; Zhang, Cheng; Smith, Maree. "Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation". Pharmaceutics 10 4 (2018): 264. http://dx.doi.org/10.3390/pharmaceutics10040264.
    10.3390/pharmaceutics10040264
  34. Parilti, Rahmet; Caprasse, Jérémie; Riva, Raphaël; Alexandre, Michaël; Vandegaart, Hélène; Bebrone, Carine; Dupont-Gillain, Christine; Howdle, Steven M.; Jérôme, Christine. "Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide". Journal of Colloid and Interface Science 532 (2018): 112-117. http://dx.doi.org/10.1016/j.jcis.2018.07.125.
    10.1016/j.jcis.2018.07.125
  35. Parilti, Rahmet; Riva, Raphaël; Howdle, Steven M.; Dupont-Gillain, Christine; Jerome, Christine. "Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide". International Journal of Pharmaceutics 549 1-2 (2018): 161-168. http://dx.doi.org/10.1016/j.ijpharm.2018.07.060.
    10.1016/j.ijpharm.2018.07.060
  36. Alexander, W.H.; Wickson, J.; Duncan, J.; Carmichael, K.; Irvine, D.J.; Howdle, S.M.. "Synthesis and control of crosslinked poly(acrylic acid) based viscosity modifiers using dense phase carbon dioxide as a solvent". The Journal of Supercritical Fluids 139 (2018): 38-44. http://dx.doi.org/10.1016/j.supflu.2018.05.003.
    10.1016/j.supflu.2018.05.003
  37. Pepper, Katie Jayne; Masson, Timothé; De Focatiis, Davide; Howdle, Steven M.. "Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation". The Journal of Supercritical Fluids 133 (2018): 343-348. http://dx.doi.org/10.1016/j.supflu.2017.10.014.
    10.1016/j.supflu.2017.10.014
  38. Guping He; Thomas M. Bennett; Mohammad Alauhdin; Michael W. Fay; Xin Liu; Simon T. Schwab; Cheng-gong Sun; Steven M. Howdle. "A facile route to bespoke macro- and mesoporous block copolymer microparticles". Polymer Chemistry 9 27 (2018): 3808-3819. https://doi.org/10.1039/C8PY00707A.
    10.1039/C8PY00707A
  39. Payal Baheti; Olinda Gimello; Cécile Bouilhac; Patrick Lacroix-Desmazes; Steven M. Howdle. "Sustainable synthesis and precise characterisation of bio-based star polycaprolactone synthesised with a metal catalyst and with lipase". Polymer Chemistry 9 47 (2018): 5594-5607. https://doi.org/10.1039/C8PY01266K.
    10.1039/C8PY01266K
  40. Pearce, Amanda K.; Travanut, Alessandra; Couturaud, Benoit; Taresco, Vincenzo; Howdle, Steven M.; Alexander, Morgan R.; Alexander, Cameron. "Versatile Routes to Functional RAFT Chain Transfer Agents through the Passerini Multicomponent Reaction". ACS Macro Letters 6 7 (2017): 781-785. http://dx.doi.org/10.1021/acsmacrolett.7b00415.
    10.1021/acsmacrolett.7b00415
  41. Muhammad Gulfam; Teresa Matini; Patrícia F. Monteiro; Raphaël Riva; Hilary Collins; Keith Spriggs; Steven M. Howdle; Christine Jérôme; Cameron Alexander. "Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells". Biomaterials Science 5 3 (2017): 532-550. https://doi.org/10.1039/C6BM00888G.
    10.1039/C6BM00888G
  42. M. Benedetti; T. R. Congdon; S. P. Bassett; M. Alauhdin; S. M. Howdle; D. M. Haddleton; R. Pisano; M. Sangermano; T. L. Schiller. "Synthesis of polymeric microcapsules by interfacial-suspension cationic photopolymerisation of divinyl ether monomer in aqueous suspension". Polymer Chemistry 8 6 (2017): 972-975. https://doi.org/10.1039/C6PY01782G.
    10.1039/C6PY01782G
  43. Simon P. Bassett; Natasha A. Birkin; James Jennings; Emma Chapman; Rachel K. O'Reilly; Steven M. Howdle; Helen Willcock. "One-pot synthesis of micron-sized polybetaine particles; innovative use of supercritical carbon dioxide". Polymer Chemistry 8 31 (2017): 4557-4564. https://doi.org/10.1039/C7PY00455A.
    10.1039/C7PY00455A
  44. Deepak Kakde; Vincenzo Taresco; Kuldeep K. Bansal; E. Peter Magennis; Steven M. Howdle; Giuseppe Mantovani; Derek J. Irvine; Cameron Alexander. "Amphiphilic block copolymers from a renewable e-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release". Journal of Materials Chemistry B 4 44 (2016): 7119-7129. https://doi.org/10.1039/C6TB01839D.
    10.1039/C6TB01839D
  45. Reinwald, Y.; Johal, R. K.; Ghaemmaghami, A. M.; Rose, F. R. A. J.; Howdle, S. M.; Shakesheff, K. M.. "Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution". Polymer 55 1 (2014): 435-444. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330207100055&KeyUID=WOS:000330207100055.
    10.1016/j.polymer.2013.09.041
  46. Tayton, E; Purcell, M; Aarvold, A; Smith, J O; Briscoe, A; Kanczler, J M; Shakesheff, K M; et al. "A comparison of polymer and polymer-hydroxyapatite composite tissue engineered scaffolds for use in bone regeneration. An in vitro and in vivo study.". Journal of biomedical materials research. Part A 102 8 (2014): 2613-24. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:24038868&KeyUID=MEDLINE:24038868.
    10.1002/jbm.a.34926
  47. Gutierrez, C.; Garcia, M. T.; Curia, S.; Howdle, S. M.; Rodriguez, J. F.. "The effect of CO2 on the viscosity of polystyrene/limonene solutions". Journal of Supercritical Fluids 88 (2014): 26-37. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335100100004&KeyUID=WOS:000335100100004.
    10.1016/j.supflu.2014.01.012
  48. Tayton, Edward; Purcell, M.; Aarvold, A.; Smith, J. O.; Kalra, S.; Briscoe, A.; Shakesheff, K.; et al. "Supercritical CO2 fluid-foaming of polymers to increase porosity: A method to improve the mechanical and biocompatibility characteristics for use as a potential alternative to allografts in impaction bone grafting?". Acta Biomaterialia 8 5 (2012): 1918-1927. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000302989700026&KeyUID=WOS:000302989700026.
    10.1016/j.actbio.2012.01.024
  49. Baxendale, Aj; van Hooff, P.; Durrant, L. G.; Spendlove, I.; Howdle, S. M.; Woods, H. M.; Whitaker, M. J.; et al. "Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology". International Journal of Pharmaceutics 413 1-2 (2011): 147-154. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000292583600019&KeyUID=WOS:000292583600019.
    10.1016/j.ijpharm.2011.04.053
  50. White, L. J.; Hutter, V.; Howdle, S. M.; Shakesheff, K. M.. "Controlling the morphology and mechanical properties of supercritical fluid foamed scaffolds". Journal of Pharmacy and Pharmacology 62 10 (2010): 1503-1504. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000281563700268&KeyUID=WOS:000281563700268.
  51. Jordan, F.; Naylor, A.; Kelly, C. A.; Howdle, S. M.; Lewis, A.; Illum, L.. "Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: In vivo studies". Journal of Controlled Release 141 2 (2010): 153-160. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000274673300006&KeyUID=WOS:000274673300006.
    10.1016/j.jconrel.2009.09.013
  52. GUALANDI, C; WHITE, LJ; CHEN, L; GROSS, RA; SHAKESHEFF, KM; HOWDLE, SM; SCANDOLA, M. "Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester". ACTA BIOMATERIALIA 6 1 (2010): 130-136. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000273087900015&KeyUID=WOS:000273087900015.
    10.1016/j.actbio.2009.07.020
  53. YANG, JX; HYDE, JR; WILSON, JW; MALLIK, K; SAZIO, PJ; O'BRIEN, P; MALIK, MA; et al. "Continuous Flow Supercritical Chemical Fluid Deposition of Optoelectronic Quality CdS". ADVANCED MATERIALS 21 41 (2009): 4115-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000272110000005&KeyUID=WOS:000272110000005.
    10.1002/adma.200803751
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Intellectual property

Patent
  1. 2017. "TERPENE AND TERPENOID DERIVATIVES CONTAINING VINYL GROUPS FOR THE PREPARATION OF POLYMERS". United Kingdom.
  2. 2007. "Fabrication Of Metamaterials".
  3. 2007. "Preparing Active Polymer Extrudates".
  4. 2005. "Polymer composition loaded with cells".
  5. 2005. "Polymer composite with internally distributed deposition matter".
  6. 2005. "Impregnation of polymeric substrates wit antimicrobal substances using superficial fluids".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11 Plenary Lecturer – Brightlands Sustainable Polymer Meeting
(Netherlands)
2019/11 Keynote Lecture – Sustainability in the Cosmetics Industry
(United Kingdom)
2019/10 Plenary Lecture – Green Chemistry
(Russia)
2018/12 Keynote Lecture Green Materials Conference
(United Kingdom)
2017/10 Plenary Lecturer 9th Scientific and Engineering Conference on Supercritical Fluids: Sochi
2017/05 Keynote Lecturer APME 17 (Polymers and Engineering)
2017/04 Plenary and Inaugural Pan Africa Chemistry Network Seminar Series lecturer - Addis Ababa and Nairobi

Association member

Society Organization name Role
2013 - Current Royal Society of Chemistry (RSC)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2005 - 2005 Visiting Professor of Chemical Engineering at the University of Pittsburgh

Scientific expedition

Activity description Institution / Organization
2005 - 2006 Leverhulme Study Abroad Fellowship
Distinctions

Award

2021 Lord Dearing Award as part of the Apprenticeship Development Team for our level 6 laboratory sciences course awarded for innovative approaches to delivery of this programme.
2009 Chartered Chemist of the Royal Society of Chemistry (CChem)
2009 IChemE Hanson Medal
2008 RSC/SCI Macro Group UK Medal
2006 DECHEMA Award of the Max Buchner Research Foundation
2005 RSC Interdisciplinary Award
2003 Royal Society Wolfson Research Merit Award
2002 Winner Joint Research Council Business Plan Competition
2001 Corday-Morgan Medal and Award of Royal Society of Chemistry
2001 Jerwood-Salters Environment Award