Identification
            Personal identification
- Full name
- Ivette Pacheco Leyva
Citation names
- Pacheco-Leyva, Ivette
Author identifiers
- Ciência ID
- B812-0D5C-4983
- ORCID iD
- 0000-0003-3006-2264
Telephones
- Telephone
- 
                           - 220408800 Ext.: 6178 (Professional)
 
Addresses
- i3S-Instituto de Investigação e Inovação em Saúde, Genetic Dynamics of Cancer Cells Unit. Universidade do Porto. IPATIMUP-Institute of Pathology and Molecular Immunology. Rua Alfredo Allen, 208 , 4200-135, Porto, Porto, Portugal (Professional)
Knowledge fields
- Natural sciences - Biological Sciences - Molecular Biology
- Medical and Health Sciences - Clinical Medicine - Oncology
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review | 
|---|---|---|---|---|---|
| Spanish; Castilian (Mother tongue) | |||||
| Portuguese | Proficiency (C2) | Proficiency (C2) | Advanced (C1) | Proficiency (C2) | Advanced (C1) | 
| English | Intermediate (B1) | Advanced (C1) | Advanced (C1) | Upper intermediate (B2) | Upper intermediate (B2) | 
Education
            | Degree | Classification | |
|---|---|---|
| 2018/09/10 - 2018/09/28 Concluded | FELASA Category C (Outros) Major in Course in Laboratory animal science Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | |
| 2015/02/13 Concluded | Ciências Biomédicas e Medicina (Doutoramento) Universidade do Algarve, Portugal Universidade do Algarve Centro de Investigação em Biomedicina, Portugal "Study of the molecular mechanism involved in cell differentiation of embryonic stem cells" (THESIS/DISSERTATION) | Muito bom | 
| 2007 Concluded | Biochemical Sciences (Master) Universidad Nacional Autónoma de México Instituto de Biotecnología, Mexico "The roles of the main components on the inoculum in cultures of A. vinelandii in determining alginate production and its
                                       mean molecular weight" (THESIS/DISSERTATION) | 8.45/10 | 
| 2003/02 - 2004/01 Attended | Chemical Pharmaceutical and Biology, BSc. (Licenciatura) Universidad Veracruzana - Facultad de Ciencias Químicas, Mexico | |
| 2003 Concluded | Chemical Engineering (Bachelor) Universidad Veracruzana - Facultad de Ciencias Químicas, Mexico "Vanilla (Vanilla planifolia A.) Extract Microencapsulation by Spontaneus Nucleation" (THESIS/DISSERTATION) | 7.8/10 | 
Affiliation
            Science
| Category Host institution | Employer | |
|---|---|---|
| 2024/01/16 - 2026/07/15 | Contracted Researcher (Research) | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | 
| Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | ||
| 2021/10/01 - 2023/01/30 | Visiting Researcher (Research) | Universidade do Porto Faculdade de Medicina, Portugal | 
| Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | ||
| 2016/05/01 - 2021/06/30 | Postdoc (Research) | Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal | 
| Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal (...) | ||
| 2015/07/01 - 2016/01/31 | Postdoc (Research) | Pontifica Universidad Católica de Valparaíso - Escuela de Ingeniería Bioquímica, Chile | 
| 2009/01/05 - 2010/02/28 | Research Trainee (Research) | Instituto de Biologia Experimental e Tecnológica, Portugal | 
| 2004/09/01 - 2007/08/31 | Research Trainee (Research) | Universidad Nacional Autónoma de México Instituto de Biotecnología, Mexico | 
Others
| Category Host institution | Employer | |
|---|---|---|
| 2015/03/01 - 2015/06/30 | Postdoctoral student (volunteer) at the Molecular Biology of Leukemia Laboratory, under supervision of Nuno R. dos Santos, PhD. | Universidade do Algarve - Campus de Gambelas, Portugal | 
| 2014/11/16 - 2015/02/28 | Research Assistant (volunteer) under the supervision of Matthias Fustchik, PhD, and José Bragança, PhD | Universidade do Algarve - Campus de Gambelas, Portugal | 
| 2010/03/01 - 2014/11/15 | PhD Student at Stem Cell lab, under supervision of José Bragança, PhD. | Universidade do Algarve - Campus de Gambelas, Portugal | 
| 2002/02/04 - 2003/06/30 | Uncompleted Bsc. Químico Farmacéutico Biólogo | Universidad Veracruzana - Facultad de Ciencias Químicas, Mexico | 
| 2002/06/01 - 2003/01/31 | Research Student in Food Technology Laboratory, under the supervision of Prof CI Beristain Guevara | Universidad Veracruzana - Instituto de Ciencias Básicas, Mexico | 
| 1997/09/01 - 2002/01/31 | Bachelor of Engineering, Chemical Engineering. | Universidad Veracruzana - Facultad de Ciencias Químicas, Mexico | 
Projects
            Grant
| Designation | Funders | |
|---|---|---|
| 2018/07/01 - 2021/06/01 | Determining the role of the microenvironment in shaping the spectrum of genetic mutations acquired during cancer development POCI-01-0145-FEDER-032592 Post-doc
                                     Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Fundação para a Ciência e a Tecnologia Ongoing | 
| 2016/05/02 - 2019/12/31 | Advancing cancer research: from basic knowledge to application Norte-010145FEDER000029 Post-doc Fellow
                                     Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Concluded | 
Contract
| Designation | Funders | |
|---|---|---|
| 2021 - 2022 | Mechanisms of central nervous system infiltration in Philadelphia chromosome-like B-cell precursor acute leukemia APCL-SPH-AMGEN Post-doc
                                     Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Associação Portuguesa Contra a Leucemia Sociedade Portuguesa de Hematologia Amgen Biofarmaceutica Lda Concluded | 
Other
| Designation | Funders | |
|---|---|---|
| 2022 - 2023 | PSGL-1 immune checkpoint protein antibody blockade as a strategy to increase human T-cell responses against lymphoma APCL-SPH-GILEAD Post-doc
                                     Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Associação Portuguesa Contra a Leucemia Sociedade Portuguesa de Hematologia Gilead Sciences Lda Concluded | 
| 2021 - 2022 | Towards an antibody-mediated targeted therapy against T-cell acute leukemia AstraZeneca Post-doc
                                     Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Fundação AstraZeneca Concluded | 
| 2018 - 2020 | IMUNOLINF: PSGL-1 protein as a novel immunotherapeutic target against lymphoma PGG/038/2017 Post-doc Fellow
                                     Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | Gilead Sciences Lda Concluded | 
Outputs
            Publications
| Book | 
 | 
| Book chapter | 
 | 
| Conference poster | 
 | 
| Journal article | 
 | 
| Magazine article | 
 | 
Activities
            Oral presentation
| Presentation title | Event name Host (Event location) | |
|---|---|---|
| 2022/07/30 | T-cell receptor and Ccr7 chemokine receptor involvement in leukemic T cell dissemination | 5th ASPIC International congress ASPIC- Portuguese Association for Cancer Research;  IPO (Oporto, Portugal) | 
| 2022/05/02 | Leukemic T cells stimulate NF-¿B signaling in stromal cells through lymphotoxin-ß receptor stimulation | European NF-kappaB Subunit workshop  (Oporto, Portugal) | 
| 2021 | T-cell receptor and Ccr7 chemokine receptor role in leukemic T cell dissemination. Poster Pitch presentation. | 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia. European School of Hematology (London, United Kingdom) | 
| 2020/03/02 | T-cell receptor and Ccr7 chemokine receptor role in leukemic T cell dissemination | Tumor Microenvironment Associação Portuguesa de Investigação em Cancro, European Association for Cancer Research,  American Association for Cancer
                                    research (Lisbon, Portugal)
                                  | 
| 2017/03 | Unraveling the role of lymphotoxin signaling in T-cell acute leukemia molecular crosstalk with microenvironmental cells | T-ALL workshop Katholieke Universiteit Leuven (Leuven, Belgium) | 
| 2017 | Pitch presentation at workshop EHA Experimental Research Meeting in Molecular Aspects of Hematological Disorders. Title: Unraveling the role of lymphotoxin signaling in T-cell acute leukemia molecular crosstalk with microenvironmental cells. | 22nd European hematology Association European Hematology Association (Madrid, Spain) | 
Supervision
| Thesis Title Role | Degree Subject (Type) Institution / Organization | |
|---|---|---|
| 2019/07/01 - 2021/09/30 | Impact of tumor-associated myeloid cell depletion on T-cell leukemia development. Co-supervisor of Telma Filipa Lopes dos Santos Costa | Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal | 
Event participation
| Activity description Type of event | Event name Institution / Organization | |
|---|---|---|
| 2023/03/29 - 2023/03/31 | Poster Presenter: T-cell receptor induction of CCR7 chemokine receptor promotes leukemic T cell dissemination Meeting | 48th annual meeting SPI Sociedade Portuguesa de Imunologia, Portugal Universidade de Aveiro, Portugal | 
| 2022/06/20 - 2022/06/23 | Poster presenter: T-cell receptor induction of CCR7 chemokine receptor promotes leukemic T cell dissemination Congress | EACR 2022, Innovative cancer science European Association For Cancer Research, United Kingdom | 
| 2022/05/12 - 2022/05/13 | Poster presenter. T-cell receptor and Ccr7 chemokine receptor involvement in leukemic T cell dissemination Meeting | 28th porto cancer meeting Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal | 
| 2021/10/14 - 2021/10/15 | Poster presenter: T-cell receptor and Ccr7 chemokine receptor involvement in leukemic T cell dissemination Meeting | II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer Associação Portuguesa de Investigação em Cancro, Portugal ASEICA, Asociación Española de Investigación sobre el Cáncer, Spain | 
| 2021/05/20 - 2021/05/21 | Poster presenter: T-cell receptor and Ccr7 chemokine receptor involvement in leukemic T cell dissemination Congress | 27th PORTO CANCER MEETING | Stemness & Metastasis: Advances in Research and Clinical Translation Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | 
| 2020/03/02 - 2020/03/04 | Poster presenter: The thymic microenvironment as a driver in T cell leukemia Conference | ASPIC EACR-AACR Eacr conference on Tumor Microenvironment | 
| 2019/09/12 - 2019/09/13 | Attended the ASEICA-ASPIC International meeting, Current trends in Immunotheraphy Research and Treatment Congress | ASEICA-ASPIC International meeting, Current trends in Immunotheraphy Research and Treatment | 
| 2019/02/24 - 2019/02/26 | Attended the 3rd Scientific Workshop European School Haematology - The Haematological Tumour Microenvironment and its Therapeutic
                                 Targeting Meeting | The Haematological Tumour Microenvironment and its Therapeutic Targeting | 
| 2019/02/24 - 2019/02/26 | Poster presentation: Dissemination of CCR7-Expressing Leukemic T Cells to Lymph Nodes Depends on NF-kb Dependent Chemokine
                                 Production Meeting | The Haematological Tumour Microenvironment and its Therapeutic Targeting | 
| 2018/10/08 - 2018/10/10 | Attended the 4th European NF-kappaB Subunit, Grasse, France. Meeting | 4th European NF-kappaB Subunit | 
| 2018/06 - 2018/06 | Presenting author: Leukemic T cells stimulate NF-kappaB signaling in stromal cells through lymphotoxin-ß receptor stimulation Conference | 25th European Association for Cancer Research European Association For Cancer Research, United Kingdom | 
| 2018 - 2018 | Presenting author for poster: Leukemic T cells stimulate NF-kappaB signaling in stromal cells through lymphotoxin-ß receptor
                                 stimulation Conference | 3rd Portuguese association for cancer research | 
| 2017/09 - 2017/09 | OUTREACH SCIENCE activities for children,  2017 European Researcher's night. Exhibition | European Researchers night Universidade do Porto, Portugal | 
| 2017 - 2017 | Presenting author for the poster: Unraveling the role of lymphotoxin signaling in T-cell acute leukemia molecular crosstalk
                                 with microenvironmental cells. Conference | 8th Meeting on signal transduction Instituto de Medicina Molecular, Portugal | 
| 2016/05/17 - 2016/05/19 | Presenting author for poster: Unraveling the role of lymphotoxin signaling in T-cell acute leukemia molecular crosstalk with
                                 microenvironmental cells Conference | 24th porto cancer meeting Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | 
| 2014 - 2014 | Outreach scientific activities for children Exhibition | Dia de portas abertas- Open day Universidade do Algarve, Portugal | 
| 2013/06/07 - 2013/06/10 | Presenting author : Molecular mechanism involved in cardiac differentiation from ESC Symposium | EMBO | EMBL Symposium Cardiac Biology: From Development to Regenerative Medicine. Heidelberg, Germany European Molecular Biology Laboratory, Germany | 
| 2010/09/24 - 2010/09/24 | Participation in Cientistas de Pe, stand up comedy about science. Exhibition | European Researchers night | 
Association member
| Society Organization name | Role | |
|---|---|---|
| 2023/02/01 - Current | Portuguese Society for Immunology | Member | 
| 2017 - Current | European association for cancer research | Member | 
| 2017 - Current | Portuguese Association for Cancer Research (ASPIC) (Associação Portuguesa de Investigação em Cancro) | Member | 
| 2017 - Current | European Hematology Association | Member | 
| 2017/01/01 - 2022/12/31 | Mexican National Research System (SNI) | Member | 
Course / Discipline taught
| Academic session | Degree Subject (Type) | Institution / Organization | |
|---|---|---|---|
| 2011/07 - 2012/01 | Microbiology practical lectures, 2011 (Universidade do Algarve, Portugal) | Ciencias Biomédicas (Licenciatura) | Universidade do Algarve Centro de Investigação em Biomedicina, Portugal | 
| 2010/07 - 2011/01 | Microbiology practical lectures, 2010 (Universidade do Algarve, Portugal) | Ciências Biomédicas (Licenciatura) | Universidade do Algarve Centro de Investigação em Biomedicina, Portugal | 
Evaluation committee
| Activity description Role | Institution / Organization | Funding entity | |
|---|---|---|---|
| 2022/07/01 - 2022/07/30 | Evaluator of doctoral scholarships from the Mexican National Postgraduate Program. Academic peer-review committee participation
                                 in 2022 call for international scholarships (France) in Health and medical sciences. Evaluator | Consejo Nacional de Ciencia y Tecnología, Mexico Gobierno Federal de México, Mexico | Gobierno Federal de México | 
| 2021/11/30 - 2021/11/30 | 4th PhDay: Break borders and build opportunities.
                                 scientific committee Evaluator | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal | |
| 2021/07/01 - 2021/08/01 | Evaluator of Postdoctoral scholarships from the Mexican National Postgraduate Program. Academic peer-review committee participation. Evaluator | Consejo Nacional de Ciencia y Tecnología, Mexico Gobierno Federal de México, Mexico | Gobierno Federal de México | 
| 2019/07/01 - 2019/07/31 | Evaluator of Postdoctoral scholarships from the Mexican National Postgraduate Program. Evaluator | Consejo Nacional de Ciencia y Tecnología, Mexico Gobierno Federal de México, Mexico | Consejo Nacional de Ciencia y Tecnología | 
Interview (tv / radio show)
| Program | Topic | |
|---|---|---|
| 2021/04/17 - 2021/04/17 | Interviewing the Cientistas-de-pé. In The Portuguese Semester, organised on the occasion of the Portuguese Presidency of the Council of the European Union, with the objective to promote and disseminate Portuguese culture. | Stand up scientists - is it a joke? | 
Mentoring / Tutoring
| Topic | Student name | |
|---|---|---|
| 2017/06 - 2018/09 | Mentoring and laboratory instructor of a Oncobiology Master student | Marina Baessa | 
| 2016/09 - 2017/06 | Mentoring and laboratory instructor Master student | Marta Araújo | 
| 2014/01/01 - 2014/04/30 | Laboratory instructor of Medicine internship trainee | Liliane Guevara | 
| 2013/01/01 - 2013/04/30 | Laboratory instructor of Medicine internship trainee | Ana Henriques | 
| 2013 - 2013 | Supervisor of Biomedicine undergrad research projects | Micaela Bento | 
| 2011 - 2011 | Supervisor of Biomedicine undergrad research projects | Patricia Ramos | 
| 2010 - 2010 | Supervisor of Biomedicine undergrad research projects | Joana Martins | 
| 2006/06 - 2006/08 | Laboratory instructor of undergraduate internship trainee (Institute of Biotechnology, UNAM, Mexico) | Lenin Hernandez | 
Distinctions
            Award
| 2013 | Poster prize at EMBO-EMBL Symposium Cardiac Biology: From Development to Regenerative Medicine. European Molecular Biology Laboratory, Germany | 
Other distinction
| 2020 | Member of Mexican National Research System, level 1 Consejo Nacional de Ciencia y Tecnología, Mexico | 
| 2017 | Certificate of Appointment from Mexican National Research System, level candidate Consejo Nacional de Ciencia y Tecnología, Mexico | 
| 2015 | VRIEA Postdoctoral grant Pontifica Universidad Católica de Valparaíso - Escuela de Ingeniería Bioquímica, Chile | 
| 2013 | EMBO-EMBL Travel Grant. European Molecular Biology Laboratory, Germany | 
| 2009 | PhD research Grant Fundação para a Ciência e a Tecnologia, Portugal | 
| 2009 | Research Grant - Bolsa de investigação científica Instituto de Biologia Experimental e Tecnológica, Portugal | 
| 2008 | Excellence Grant | 
| 2004 | Master Research Grant Consejo Nacional de Ciencia y Tecnología, Mexico | 
| 2000 | Summer school Grant Centro de Investigaciones en Óptica AC, Mexico | 
| 1999 | Bachelor Grant Universidad Veracruzana, Mexico | 
