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Sara R. M. M. de Aguiar obtained her PhD in Chemistry with distinction in 2017 from the Technische Universität Wien (TU Wien) under the supervision of Prof. Karl Kirchner. She is currently a Research Fellow in an Applied Materials (AMAT)/National University of Singapore (NUS) financed project, at National University of Singapore. In the last 11 years, she published 17 articles in international peer-reviewed scientific journals, presented 4 oral communications and 10 poster communications. Citation metrics in Web of Science (AAG-7871-2021) indicate 15 papers (8 first author) with 162 citations and an h-index of 7. She was a team member in 8 projects financed by FCT (Portugal), FWF (Austria) and ERC (Belgium), and was a Research Fellow in two of these. Since 2016, she mentored 3 bachelor¿s students and 2 PhD students in the field of organometallic chemistry with catalytic purpose and for biomedical applications and in the area of biochemistry. Her researcher interests are in the interface of Exact Chemical Sciences and Natural Biological Science with emphasis on Inorganic Chemistry and Biochemistry. She is skilled in organic and inorganic synthesis for catalytic and nanomedicine applications and more recently is focused on mechanistic studies on metalloproteins.
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Identification

Personal identification

Full name
Sara Raquel Mota Merelo de Aguiar

Citation names

  • Sara R. M. M. de Aguiar
  • Sara Raquel M. M. de Aguiar

Author identifiers

Ciência ID
B71C-0A78-2F7E
ORCID iD
0000-0002-7152-1255
Google Scholar ID
https://scholar.google.com/citations?user=UCkVcT4AAAAJ&hl=pt-BR&oi=ao
Researcher Id
AAG-7871-2021
Scopus Author Id
36990806400

Email addresses

  • sr.aguiar@fct.unl.pt (Professional)
  • srmma@nus.edu.sg (Professional)

Addresses

  • NUS S9 Wet Science Building, 4 Science Drive 2, 117544, Singapore, Singapore, Singapore (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1)
German Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Elementary (A2) Upper intermediate (B2)
French Beginner (A1) Elementary (A2) Beginner (A1) Intermediate (B1)
Japanese Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019
Concluded
 Positron Emission Tomography (PET): Technology and Application (Outros)
King's College London, United Kingdom
2013/08 - 2017/08
Concluded
 PhD Chemistry (Doutoramento) (Doktor (PhD))
Technische Universität Wien, Austria
"Molybdenum and Tungsten PNP Pincer Complexes" (THESIS/DISSERTATION)
 Mit Auszeichnung bestanden (Pass with Distinction)
2016
Concluded
 Project Management Training (Outros)
Technische Universität Wien, Austria
2015
Concluded
 The Craft of Scientific Writing (Outros)
Technische Universität Wien, Austria
 obtained with excellent (1)
2014
Concluded
 Transmission Electron Microscopy (Outros)
Technische Universität Wien, Austria
 obtained with excellent (1)
2012
Concluded
 Modern Methods of Structure Elucidation (Outros)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2009 - 2011/12
Concluded
 M.Sc. in Chemistry (Mestrado)
Major in Chemistry, Health and Nutrition
Universidade de Lisboa Faculdade de Ciências, Portugal
"Corrosion processes in materials for biomedical applications and bacterial growth in artificial saliva" (THESIS/DISSERTATION)
 16 out of 20
2009/02
Concluded
 Chemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii species and rosmarinic acid on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus" (THESIS/DISSERTATION)
 14 out of 20
2009
Concluded
 Molecular Mechanism of Drugs (Outros)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007
Concluded
 Chiroptical Technics in Organic Chemistry (Outros)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2020/06/02 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/05/01 - 2019/08/31 Contracted Researcher (Research) University of Bath, United Kingdom
University of Bath, United Kingdom

Other Careers

Category
Host institution 		Employer
2020/01 - 2020/07 Professor do ensino básico e secundário (Professor do ensino básico e secundário) Externato Marquês de Pombal – grupo ensinus, Portugal

Others

Category
Host institution 		Employer
2013/02 - 2017/09 Project Assistant Technische Universität Wien, Austria
2012/03 - 2012/12 Research fellow for masters (Strategic Project PEstOE/QUI/UI100/2011-2012) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2008/09 - 2009/07 Research Fellow (BII) (Project PTDC/QUI/71576/2006) Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2020/06 - Current PathG_CCP - Detoxification of hydrogen peroxide by pathogenic bacteria -Three-haem peroxidases from E.coli as a model
PTDC/BIA-BQM/29442/2017
Contracted Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Ongoing
2018/05 - 2019/08 Oxygen Sensing with Multimodality Imaging Probes
617107
Research Associate
University of Bath, United Kingdom
 European Research Council
Concluded
2016 - 2017 Environmentally benign catalytic reactions based on iron
info:eu-repo/grantAgreement/FWF/Einzelprojekte/P 28866/AT
Project Assistant
Technische Universität Wien, Austria
 Fonds zur Förderung der wissenschaftlichen Forschung
Concluded
2013/02 - 2017 Carbonylation of Coordinatively Unsaturated Iron Complexes
info:eu-repo/grantAgreement/FWF/Einzelprojekte/P 24202/AT
Project Assistant
Technische Universität Wien, Austria
 Fonds zur Förderung der wissenschaftlichen Forschung
Concluded
2015 - 2016 Iron-catalyzed asymmetric hydrogenations and transfer hydrogenations of ketones
T 631 Firnberg-Programm
Researcher
Technische Universität Wien, Austria
 Fonds zur Förderung der wissenschaftlichen Forschung
Concluded
2012/03 - 2012/12 Projecto estratégico - UI 100 - 2011-2012
PEstOE/QUI/UI100/2011-2012
Master Student Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2011 Biocorrosion in dental materials
info:eu-repo/grantAgreement/FCT/POCI/56029/PT
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
2008/09 - 2009/07 Design of new catalysts for enantioselective oxidation catalysis
info:eu-repo/grantAgreement/FCT/3599-PPCDT/71576/PT
Integration into Research Grant Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2007 - 2007 Hallmarks in Science and Techniques through Lisbon (Marcas das Ciências e das Técnicas pelas ruas de Lisboa)
Non-funded
Collaborator
Centro Interdisciplinar de Ciência, Tecnologia e Sociedade da Universidade de Lisboa, Portugal
Cancelled
Outputs

Publications

Conference poster
  1. Williams, G.; Cortezon-Tamarit, F.; Ge, H.; de Aguiar, Sara R. M. M.; Estrela, P.; MacKenzie, A.; Pascu, S. I.. "Imaging and sensing with metallodrugs and nanomedicines for hypoxic prostate tumours". Paper presented in Bolland Symposium 2018, 2018.
  2. Ge, H.; Sarpaki, S.; Cortezon-Tamarit, F.; de Aguiar, Sara R. M. M.; Mirabello, V.; Eggleston, I.; Carroll, L.; Aboagye, E.; Pascu, S. I.. "Coordination Chemistry of Gallium (III) in Water for the imaging of cancer cells under hypoxic conditions". Paper presented in European Biological Inorganic Chemistry Conference (EuroBic 14), 2018.
  3. Williams, G.; Cortezon-Tamarit, F.; Ge, H.; de Aguiar, Sara R. M. M.; Estrela, P.; MacKenzie, A.; Pascu, S. I.. "Confocal Fluorescence Imaging with metallodrugs incorporating O/N/S Donors for prostate cancer cells under hypoxia". Paper presented in European Biological Inorganic Chemistry Conference (EuroBic 14), 2018.
  4. de Aguiar, Sara R. M. M.; Stöger, B.; Kirchner, K.. "New development on the chemistry of Group Six PCP Pincer complexes". Paper presented in XXXIV GEQO Congress Organometallic Chemistry Group, 2016.
  5. de Aguiar, Sara R. M. M.; Kirchner, K.. "Synthesis and reactivity of Molybdenum PNP pincer complexes". Paper presented in XXVI International Conference on Organometallic Chemistry, 2014.
  6. Barroso, Sonia; de Aguiar, Sara R. M. M.; Azevedo, C. G.; Calhorda, M. J.. "Reactivity of Molydenum and Tungsten Complexes supported by Chiral N-heterocyclic carbene (NHC) ligands". Paper presented in XXV International Conference on Organometallic Chemistry, 2012.
  7. de Aguiar, Sara R. M. M.; Barroso, Sonia. "Synthesis and reactivity of New Zirconium diphenolate-NHC complexes". Paper presented in XXV International Conference on Organometallic Chemistry, 2012.
  8. de Aguiar, Sara R. M. M.; Calhorda, M. J.. "Synthesis of new Molybdenum (II) complexes and their immobilisation in clays". Paper presented in 8ª Conferência de Química Inorgânica, 2009.
Journal article
  1. Sarpaki, S.; Cortezon-Tamarit, F.; de Aguiar, Sara R. M. M.; Exner, R. M.; Divall, D.; Arrowsmith, R. L.; Ge, H.; et al. "Radio- and nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes". Nanoscale 12 12 (2020): 6603-6608.
    10.1039/c9nr10145d
  2. de Aguiar, Sara R. M. M.; Schröder-Holzhacker, C.; Pecak, J.; Stöger, B.; Kirchner, K.. "Synthesis and characterization of TADDOL-based chiral group six PNP pincer tricarbonyl complexes". Monatshefte für Chemie - Chemical Monthly (2018): https://doi.org/10.1007%2Fs00706-018-2281-0.
    10.1007/s00706-018-2281-0
  3. de Aguiar, Sara R. M. M.; Öztopcu, Ö.; Troiani, A.; de Petris, G.; Weil, M.; Stöger, B.; Pittenauer, E.; et al. "Formation of Mono Oxo Molybdenum(IV) PNP Pincer Complexes: Interplay between Water and Molecular Oxygen". European Journal of Inorganic Chemistry (2018): https://doi.org/10.1002%2Fejic.201701413.
    10.1002/ejic.201701413
  4. Zirakzadeh, A.; de Aguiar, Sara R. M. M.; Stöger, B.; Widhalm, M.; Kirchner, K.. "Enantioselective Transfer Hydrogenation of Ketones Catalyzed by a Manganese Complex Containing an Unsymmetrical Chiral PNP' Tridentate Ligand". ChemCatChem (2017): https://doi.org/10.1002%2Fcctc.201700042.
    10.1002/cctc.201700042
  5. Zirakzadeh, A.; de Aguiar, Sara R. M. M.; Widhalm, M.; Mereiter, K.; Kirchner, K.. "Iron(II) complexes featuring chiral PNNP diferrocene: Synthesis and characterization of potential hydrogenation catalysts". Journal of Organometallic Chemistry 819 (2016): 260-265. https://doi.org/10.1016%2Fj.jorganchem.2016.07.005.
    10.1016/j.jorganchem.2016.07.005
  6. de Aguiar, Sara R. M. M.; Stöger, B.; Pittenauer, E.; Allmaier, G.; Veiros, L.F.; Kirchner, K.. "Arene C–H Bond Coordination versus C–H Bond Cleavage in Low-Valent Group 6 Carbonyl Pincer Complexes". Organometallics 35 17 (2016): 3032-3039. https://doi.org/10.1021%2Facs.organomet.6b00563.
    10.1021/acs.organomet.6b00563
  7. Mastalir, M.; de Aguiar, Sara R. M. M.; Glatz, M.; Stöger, B.; Kirchner, K.. "A Convenient Solvothermal Synthesis of Group 6 PNP Pincer Tricarbonyl Complexes". Organometallics 35 2 (2016): 229-232. https://doi.org/10.1021%2Facs.organomet.5b00940.
    10.1021/acs.organomet.5b00940
  8. de Aguiar, Sara R. M. M.; Stöger, B.; Weil, M.; Kirchner, K.. "Tetrakis(µ2-diphenylphosphinato-¿2 O,O')tetra-µ3-oxido-tetraoxidohexamolybdenum(V)". IUCrData 1 1 (2016): https://doi.org/10.1107%2Fs2414314616000365.
    10.1107/s2414314616000365
  9. de Aguiar, Sara R. M. M.; Stöger, B.; Pittenauer, E.; Allmaier, G.; Veiros, L.F.; Kirchner, K.. "Structural diversity of halocarbonyl molybdenum and tungsten PNP pincer complexes through ligand modifications". Dalton Trans. 45 35 (2016): 13834-13845. https://doi.org/10.1039%2Fc6dt02251k.
    10.1039/c6dt02251k
  10. de Aguiar, Sara R. M. M.; Nicolai, M.. "Electrochemical behaviour of a cobalt-chromium-molybdenum dental alloy in artificial salivas: Influence of phosphate ions and mucin components.". (2015): http://europepmc.org/abstract/med/25585980.
    10.3233/bme-141241
  11. de Aguiar, Sara R. M. M.; Öztopcu, Ö.; Stöger, B.; Mereiter, K.; Veiros, L.F.; Pittenauer, E.; Allmaier, G.; Kirchner, K.. "Synthesis and reactivity of coordinatively unsaturated halocarbonyl molybdenum PNP pincer complexes". Dalton Trans. 43 39 (2014): 14669-14679. https://doi.org/10.1039%2Fc4dt01932f.
    10.1039/c4dt01932f
  12. Barroso, Sonia; de Aguiar, Sara R. M. M.; Munhá, R. F.. "New zirconium complexes supported by N-heterocyclic carbene (NHC) ligands: Synthesis and assessment of hydroamination catalytic properties". Journal of Organometallic Chemistry 760 (2014): 60-66. https://doi.org/10.1016%2Fj.jorganchem.2013.11.041.
    10.1016/j.jorganchem.2013.11.041
  13. de Aguiar, Sara R. M. M.; Stöger, B.; Pittenauer, E.; Puchberger, M.; Allmaier, G.; Veiros, L.F.; Kirchner, K.. "A complete series of halocarbonyl molybdenum PNP pincer complexes – Unexpected differences between NH and NMe spacers". Journal of Organometallic Chemistry 760 (2014): 74-83. https://doi.org/10.1016%2Fj.jorganchem.2013.12.018.
    10.1016/j.jorganchem.2013.12.018
  14. Vasconcellos-Dias, M.; de Aguiar, Sara R. M. M.; Nunes, Carla D.; Vaz, P. D.; Nunes, T. G.; Calhorda, M. J.. "Pyridine Carboxylate Complexes of Mo(II) as Active Catalysts in Homogeneous and Heterogeneous Olefin Epoxidation". Current Inorganic Chemistrye 1 2 (2011): 146-155. https://doi.org/10.2174%2F1877944111101020146.
    10.2174/1877944111101020146
  15. Figueiredo, N. L.; de Aguiar, Sara R. M. M.; Falé, P. L.; Ascensão, L.; Serralheiro, M. L. M.; Lino, A. R. L.. "The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans". Food Chemistry 119 2 (2010): 664-668. https://doi.org/10.1016%2Fj.foodchem.2009.07.008.
    10.1016/j.foodchem.2009.07.008
Report
  1. de Aguiar, Sara R. M. M.. 2012. Synthesis and reactivity of new complexes supported by N-heterocyclic carbene (NHC) ligands.
  2. de Aguiar, Sara R. M. M.. 2009. Synthesis of new organometallic complexes immobilization in clays and MCM-41.
Thesis / Dissertation
  1. de Aguiar, Sara R. M. M.. "Molybdenum and Tungsten PNP Pincer Complexes". PhD, Technische Universität Wien, 2017.
  2. de Aguiar, Sara R. M. M.. "Corrosion processes in materials for biomedical applications and bacterial growth in artificial saliva". Master, Universidade de Lisboa Faculdade de Ciências, 2011.
  3. de Aguiar, Sara R. M. M.. "The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii species and rosmarinic acid on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus". Degree, Universidade de Lisboa Faculdade de Ciências, 2008.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015 Oxygen and Nitrogen activation by Molybdenum Pincer complexes
(Austria)
2015 Molybdenum and Tungsten PNP Pincer Complexes
(Austria)
2012 Structural characterization of a Zirconium Diphenolate-NHC complex
2010 Synthesis of new organometallic complexes immobilization in clays and MCM-41
(Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 Member of the organization team of the Quantum Bioinorganic Chemistry IV (QBIC IV) Conference (2018 - 2018) University of Bath, United Kingdom

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019 - 2019 This workshop is focus on how to recognise, understand and overcome imposter syndrome. Allowing the participants to share experiences and brainstorm strategies for reducing the impostor feelings in yourself and/or among students.
Workshop
 Imposter Syndrome Workshop
University of Bath, United Kingdom
2018 - 2018 A workshop for chromatographic and mass spectrometric techniques that will cover the essentials that every scientist needs in order to make effective use of these key instruments, including: introduction of HPLC/nanoLC and their use in MS proteomics, introduction of GC, LC-MS data analysis with examples, holding practical sessions.
Workshop
 Fundamental Chromatographic and Mass Spectrometric Techniques
University of Bath, United Kingdom
2018 - 2018 The Basic Fire Fighting course entails firefighting techniques and how to apply them in a safe and correct manner. This course is aimed at preventing fires, creating a prepared environment, and building confidence when faced with this unexpected emergency.
Workshop
 Basic Fire Training
University of Bath, United Kingdom
2010 - 2010 A three days course covering the drug research value chain, lead identification strategies, neuraminidase inhibitors, synthesis in research and development to practical examples and case studies.
Workshop
 Industrial Drug Research - Roche
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2008 Supervision of Teams competing in the Junior Olympics in Chemistry Junior Olympics in Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2021/02 - Current Portuguese Chemical Society
2019/09 - Current Portuguese Biochemistry Society

Committee member

Activity description
Role 		Institution / Organization
2018 - 2019 Member of the Postdoctoral Research Committee of the Chemistry Department of the University of Bath (UBAH)
Member
 University of Bath, United Kingdom

Conference scientific committee

Conference name Conference host
2019 - 2019 2019 Bolland Symposium - Invited Chair of the session "Inorganic" University of Bath

Mentoring / Tutoring

Topic Student name
2020/07 - 2020/12 Supervised experimental work of a Bachelor student in Biochemistry Andreia Rodrigues
2018/05 - 2019/08 Collaborated in the supervision of a PhD student in Organometallic Chemistry field Federico Casarsa
2018/05 - 2018/10 Collaborated in the supervision of a PhD student in Organometallic Chemistry field Georgia Williams
2016 - 2016 Supervised experimental work of a Bachelor student in Organometallic Chemistry Alexandra Dworzak