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Andreia Filipa Marreiros Amaro got her BSc degree in Medical Chemistry in 2019 at the University of Coimbra (UC) and her Msc degree in Biochemistry in 2022 also at UC. Currently, she is a Ph.D. student in Health Sciences at the Faculty of Medicine of the UC focusing her research on depicting the intricate relation between neurodevelopmental disorders and energy balance pathways in the offspring of diabetic mothers. Andreia's research on developmental programming has been addressing the impact of early-life insults on offspring metabolism and behaviour. She has published 10 research articles (3 as first author and 7 as co-author). Andreia has an active participation in National and International meetings being author and co-author of several oral communications and posters. In 2023, Andreia won the best poster communication award at the European Society of Clinical Investigation in the Czech Republic. Andreia also participated in activities to promote science communication and dissemination, namely European Researcher's Night and Escola Ciência Vida at the Exploratorium of Coimbra.
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Identification

Personal identification

Full name
Andreia Filipa Marreiros Amaro

Citation names

  • Amaro, A

Author identifiers

Ciência ID
B514-ACD3-E5E3
ORCID iD
0000-0002-0959-6571

Telephones

Mobile phone
  • 926967519 (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2022/09 - 2026
Ongoing
 Ciências da Saúde (Doutoramento)
Major in Biomedicina
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09 - 2022/09/13
Concluded
 Bioquímica (Mestrado)
Universidade de Coimbra, Portugal
"Lactation Period: a window to neurometabolic disorders" (THESIS/DISSERTATION)
2016/09 - 2019/07
Concluded
 Química Medicinal (Licenciatura)
Universidade de Coimbra, Portugal
 12
Affiliation

Science

Category
Host institution 		Employer
2019/09 - Current Research Trainee (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/09 - 2022/09 Research Trainee (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2019/01 - 2019/07 Research Trainee (Research) Universidade de Coimbra Departamento de Química, Portugal
Universidade de Coimbra Departamento de Química, Portugal
Projects

Grant

Designation Funders
2022/11 - Current Depicting the intricate relation between neurodevelopmental disorders and energy balance pathways in the offspring of diabetic mothers
UI/BD/154406/2023
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2024/06 - Current New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling 2.0
COMPETE2030-FEDER-00768700
Member of the team
Fundação para a Ciência e a Tecnologia
Ongoing
2024 - Current PAS GRAS - De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults
HORIZON-HLTH-2022-STAYHLTH- 101080329
Universidade de Coimbra, Portugal
 Horizon 2020
Ongoing
Outputs

Publications

Book chapter
  1. Amaro, Andreia; Freitas, Marisa; Matafome, Paulo. "Targeting reactive carbonyls in metabolic disorders". In Pharmacological Targets in Metabolic Diseases, 79-92. Elsevier, 2026.
    10.1016/b978-0-443-27370-4.00022-6
Conference abstract
  1. Amaro, A; Baptista, FI; Castelo-Branco, Miguel; Matafome, Paulo. "Long-term behavioural and metabolic effects of maternal obesity are associated by sex-specific neuroendocrine disruption". Paper presented in 34th Congress European Childhood Obesity Group (ECOG), Uppsala, 2025.
  2. Amaro, A; Baptista, FI; Castelo-Branco, Miguel; Matafome, Paulo. "Maternal obesity disrupts central neuroendocrine mechanisms in a sex-dependent manner". Paper presented in Congresso Nacional de Fisiologia 2025, 2025.
  3. Amaro, A; Prazeres, Bruna; Baptista, FI; Castelo-Branco, Miguel; Matafome, Paulo. "Maternal metabolic dysfunction reshapes offspring brain neurometabolic and energy balance pathways in a sex-dependent manner". Paper presented in 61st European Association for the Study of Diabetes (EASD) Annual Meeting, Viena, 2025.
  4. Sousa, Diana; Rolo, Guilherme; Caramelo, Beatriz; Carina C. Magalhães; Amaro, A; Rosendo-Silva, Daniela; Matafome, Paulo. "Potential synergistic therapy for metabolic dysfunction targeting GLP-1 and dopamine receptors". Paper presented in 61st EASD Annual Meeting of the European Association for the Study of Diabetes, Viena, 2025.
  5. Sousa, Diana; Rolo, Guilherme; Caramelo, Beatriz; Carina C. Magalhães; Amaro, A; Rosendo-Silva, Daniela; Matafome, Paulo. "Synergistic effects of liraglutide and bromocriptine as potential therapy for metabolic dysfunction". Paper presented in 59th Annual Scientific Meeting of the European Society for Clinical Investigation, Genoa, 2025.
  6. Amaro, A; Baptista, FI; Castelo-Branco, Miguel; Matafome, Paulo. "Linking maternal obesity to neurodevelopment and metabolic changes in the offspring". Paper presented in 3rd International Meeting of Portuguese Society of Physiology, Coimbra, 2024.
  7. Amaro, A; Sousa, Diana; Rosendo-Silva, Daniela; Baptista, FI; Matafome, Paulo. "Postnatal overfeeding induces a sex-specific dysregulation of neuroendocrine mechanisms and an anxious-like behaviour". Paper presented in 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
  8. Sousa, Diana; Amaro, A; Rocha, Mariana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Matafome, Paulo. "Disruption of neuroendocrine mechanisms of energy balance in hypothalamus and brown adipose tissue in overfed rats exposed to maternal glycation". Paper presented in 58th Annual Scientific Meeting of the European Society of Clinical Investigation, Barcelona, 2024.
  9. Amaro, A; Sousa, Diana; Rosendo-Silva, Daniela; Baptista, FI; Matafome, Paulo. "O sistema npy/melanocortina é alterado pela sobrealimentação pós-natal em várias regiões do cérebro, estando associado a alterações comportamentais específicas de cada sexo". Paper presented in 20th Portuguese Diabetes Congress Portuguese, Vilamoura, 2024.
  10. Amaro, A; Sousa, Diana; Rocha, Mariana; Ferreira-Junior, Marcos Divino; Saavedra, Lucas; Barra, Cátia; Baptista, FI; Matafome, Paulo. "Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
  11. Sousa, Diana; Amaro, A; Rocha, Mariana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
  12. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira-Junior, Marcos Divino; Saavedra, Lucas; Mello-Gomes, Rodrigo; Baptista, FI; Matafome, Paulo. "Postnatal overweight- induced offspring neurodevelopment and behaviour alterations associated with synaptic imbalance, according to sex-specific vulnerabilities". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023.
  13. Sousa, Diana; Amaro, A; Ferreira-Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023.
  14. Amaro, A; Sousa, Diana; Rocha, Mariana; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Ferreira-Junior, Marcos Divino; Baptista, FI; Matafome, Paulo. "A exposição à glicação materna induz vulnerabilidades específicas do sexo no neurometabolismo e comportamento da descendência associadas a alterações sinápticas". Paper presented in 19th Portuguese Diabetes Congress, Vilamoura, 2023.
  15. Sousa, Diana; Rocha, Mariana; Amaro, A; Ferreira-Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "Mecanismos compensatórios de balanço energético induzidos por sobrepeso pós-natal são prejudicados em condições maternas não saudáveis". Paper presented in 19th Portuguese Diabetes Congress, Vilamoura, 2023.
  16. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Reis, F; et al. "Neurometabolic and behavioral alterations in the adolescent offspring upon maternal glycation". Paper presented in 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology, Coimbra, 2023.
  17. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, FI; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation". Paper presented in 58th European Association for the Study of Diabetes Annual Meeting, Estocolmo, 2022.
  18. Sousa, Diana; Amaro, A; Ferreira-Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue". Paper presented in 58th European Association for the Study of Diabetes Annual Meeting, Estocolmo, 2022.
  19. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; Baptista, FI; Matafome, Paulo. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
  20. Sousa, Diana; Amaro, A; Ferreira-Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue.". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
  21. Sousa, Diana; Amaro, A; Ferreira-Junior, Marcos Divino; Susana P. Pereira; Mariana Rocha; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "O desenvolvimento perinatal em ambientes obesogénicos provoca alterações nas vias de sensibilidade aos nutrientes". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
  22. Rocha, Mariana; Amaro, A; Ferreira-Junior, Marcos Divino; Susana P. Pereira; Sousa, Diana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo J.; Matafome, Paulo. "Dieta materna hipercalórica durante a gestação e lactação e desenvolvimento da resistência à insulina: papel das glicotoxinas da dieta". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
  23. Amaro, A; Sousa, Diana; Ferreira-Junior, Marcos Divino; Barra, Cátia; Mariana Rocha; Monteiro-Alfredo, Tamaeh; Baptista, FI; Matafome, Paulo. Corresponding author: Amaro, A. "A glicação materna acelera o neurodesenvolvimento dos descendentes, induzindo alterações metabólicas e um comportamento menos ansioso na adolescência". Paper presented in 18th Portuguese Diabetes Congress, Vilamoura, 2022.
Journal article
  1. Saavedra, Lucas Paulo Jacinto; Raposo, Scarlett Rodrigues; Assakawa, Ana Letícia Manso; Lucredi, Naiara Cristina; Peres, Maria Natália Chimirri; Piovan, Silvano; Gonçalves, Gessica Dutra; et al. "Fenofibrate treatment during lactation prevents liver and adipose tissue associated metabolic dysfunction in a rat model of childhood obesity". Biomedicine & Pharmacotherapy 188 (2025): 118166. https://doi.org/10.1016/j.biopha.2025.118166.
    10.1016/j.biopha.2025.118166
  2. Sousa, Adelaide; Amaro, Andreia; Costa, Vera Marisa; Azevedo, Rui; Oliveira, Sara; Viana, Sofia; Reis, Flávio; et al. "Exploring quercetin's protective potential against the pro-inflammatory effects of silver nanoparticles in C57BL/6J mice". Food and Chemical Toxicology 195 (2025): 115081. https://doi.org/10.1016/j.fct.2024.115081.
    10.1016/j.fct.2024.115081
  3. Marcos Divino Ferreira-Junior; Keilah Valéria N. Cavalcante; Jaqueline M. Costa; Amanda S. M. Bessa; Andreia Amaro; Carlos Henrique de Castro; Carlos Henrique Xavier; et al. "Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats". Nutrients (2024): https://doi.org/10.3390/nu16132029.
    10.3390/nu16132029
  4. Sónia Rocha; Andreia Amaro; Marcos D. Ferreira-Junior; Carina Proença; Artur M. S. Silva; Vera M. Costa; Sara Oliveira; et al. "Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16020261.
    10.3390/pharmaceutics16020261
  5. Andreia Amaro; Diana Sousa; Mariana Sá-Rocha; Marcos Divino Ferreira-Junior; Daniela Rosendo-Silva; Lucas Paulo Jacinto Saavedra; Cátia Barra; et al. "Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes". Nutrients (2023): https://doi.org/10.3390/nu15163581.
    10.3390/nu15163581
  6. Amaro, A; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos D.; Barra, Cátia; Monteiro, Tamaeh; Mathias, Paulo; et al. "Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes". Life Sciences 321 (2023): 121597. http://dx.doi.org/10.1016/j.lfs.2023.121597.
    10.1016/j.lfs.2023.121597
  7. Diana Sousa; Mariana Rocha; Andreia Amaro; Marcos Divino Ferreira-Junior; Keilah Valéria Naves Cavalcante; Tamaeh Monteiro-Alfredo; Cátia Barra; et al. "Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models". Nutrients (2023): https://doi.org/10.3390/nu15051281.
    10.3390/nu15051281
  8. Amaro, Andreia; Baptista, Filipa I.; Matafome, Paulo. "Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders". Life Sciences (2022): 120526. http://dx.doi.org/10.1016/j.lfs.2022.120526.
    Published • 10.1016/j.lfs.2022.120526
  9. Monteiro-Alfredo, Tamaeh; Caramelo, Beatriz; Arbeláez, Daniela; Amaro, Andreia; Barra, Cátia; Silva, Daniela; Oliveira, Sara; et al. "Distinct Impact of Natural Sugars from Fruit Juices and Added Sugars on Caloric Intake, Body Weight, Glycaemia, Oxidative Stress and Glycation in Diabetic Rats". Nutrients 13 9 (2021): 2956. https://doi.org/10.3390/nu13092956.
    10.3390/nu13092956
  10. Monteiro-Alfredo, Tamaeh; Oliveira, Sara; Amaro, Andreia; Rosendo-Silva, Daniela; Antunes, Katia; Pires, Ana Salomé; Teixo, Ricardo; et al. "Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats". Nutrients 13 8 (2021): 2856. https://doi.org/10.3390/nu13082856.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2026/03/07 A obesidade materna modula as vias neuroendócrinas e comportamento da descendência, de acordo com vulnerabilidades específicas do sexo 22º Congresso de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2025/11/28 Long-term behavioural and metabolic effects of maternal obesity are associated by sex-specific neuroendocrine disruption 34th Congress European Childhood Obesity Group (ECOG)
(Uppsala, Sweden)
2025/11 Maternal obesity disrupts central neuroendocrine mechanisms in a sex-dependent manner Congresso Nacional de Fisiologia 2025
(Santarém, Portugal)
2025/09/17 Maternal metabolic dysfunction reshapes offspring brain neurometabolic and energy balance pathways in a sex-dependent manner 61st European Association for the Study of Diabetes (EASD) Annual Meeting
(Vienna, Austria)
2024/11/07 Linking maternal obesity to neurodevelopment and metabolic changes in the offspring Poster presentation 3rd International Meeting of Portuguese Society of Physiology
Faculty of Medicine of Porto (Porto, Portugal)
2023/10/05 Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance 59th European Association for the Study of Diabetes (EASD) Annual Meeting
(Hamburg, Germany)
2023/06/07 Postnatal overweight-induced offspring neurodevelopment and behaviour alterations associated with synaptic imbalance, according to sex-specific vulnerabilities 57th Annual Scientific Meeting of the European Society for Clinical Investigation
(Praga, Czech Republic)
2023/03 A exposição à glicação materna induz vulnerabilidades específicas do sexo no neurometabolismo e comportamento da descendência associadas a alterações sinápticas 19º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/02/03 Neurometabolic and behavioral alterations in the adolescent offspring upon maternal glycation 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
(Coimbra, Portugal)
2023/01 Neurometabolic and behavioral alterations in the adolescent offspring upon maternal glycation III Metabolism Aging and Disease Meeting
CIBB (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2026/02 - Current Influência da disfunção metabólica materna na regulação de hormonas sexuais da descêndencia
Co-supervisor
 Biologia (Degree)
Universidade de Coimbra, Portugal
2026/02 - Current The role of MeD compounds in the modulation of energy balance mechanisms in offspring
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal
2025/02 - 2025/07 The Impact of Maternal Diabetes andObesity on Metabolic Programming and the Modulation of Neuroendocrine Pathways in Offspring
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal
2024/02 - 2024/07 Role of maternal diabetes inmodulating brain neuroendocrine pathways and its relationship with neurodevelopment: The role ofNPY/MCR in brain-specific regions inconditions of postnatal overfeeding
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal
2024/02 - 2024/07 Role of maternal diabetes in modulating brain neuroendocrine pathways and its relationship with neurodevelopment: The role of Dopaminergic system in CNS in conditions of postnatal overfeeding
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2026/01/20 - 2026/01/21 Metabolism, Aging and Disease 6th CiBB Retreat, "Shaping the Future: Metabolism, Aging and Disease in Perspective Faculty of Medicine of the University of Coimbra (Polo III) (2026/01/20 - 2026/01/21)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Association member

Society Organization name Role
2024 - Current Portuguese Society of Physiology
2022/06 - Current European Association for the Study of Diabetes (EASD)
2022 - Current Sociedade Portuguesa de Diabetologia
2021 - Current European Science of Clinical Investigation (ESCI)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/05/09 - 2025/05/09 Fundamentos de Fisiologia II (01008226) - LQM Seminário - Maternal Behaviour and its Outcomes in Offspring Behaviourand Development: a focus on Perinatal Period Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Medicina, Portugal
Distinctions

Award

2025 Estagiário Pós-Graduado de Mérito
Sociedade Portuguesa de Fisiologia, Portugal
2023 Best Poster Award
European Society for Clinical Investigation , Czech Republic