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Manuela Ferreira graduated in Biochemistry and was awarded a PhD in 2010 from Coimbra University under supervision of Fiona M. Watt (CRUK). She joined Henrique Veiga-Fernandes lab in Lisbon (iMM and Champalimaud Foundation) between 2010 and 2020 as pos-doc fellow. Notably, she is the co-first author of a highly cited Nature paper (Nature 2014, 245 citations), which was a breakthrough by establishing an unprecedented link between maternal nutrients and offspring immune system. Despite 3 career breaks due to maternity leaves and serious illness (2014-2019), so far Ferreira published 13 papers (including 6 papers as 1st author and 1 as co-senior-corresponding), which feature ca. >1800 citations, a CIF of 168 and a h-index of 10. Ferreira made ground-breaking contributions to the understanding of epithelial biology and immune-sensing field, which were published in high impact factor peer-reviewed journals such as Science, Cell, Nature, Genes & Development, and Cancer Research. She successfully secured highly competitive national funding (FCT) and received several national and international prestigious prizes, e.g. EMBO, Society for Mucosal Immunology (USA), European Society for Clinical Investigation (ESCI). She actively promotes knowledge transfer by supervising PhD, MSc and internship students; she lecture in PhD courses and participate in outreach science activities for society. In 2021, she was awarded an 6-year Assistant Researcher Grant for salary (CEECind, 2021.00594.CEECIND). Ferreira leads a team at Centre for Neuroscience and Cell Biology - Coimbra University, and is currently investigating how environmental cues shape immune cells and mucosal body barrier. Manuela is invited to review papers, including in Nature Immunology, and integrated 5 Jury of Master Scientific degree as main arguer.
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Identification

Personal identification

Full name
Manuela Ferreira

Citation names

  • Ferreira, Manuela

Author identifiers

Ciência ID
B514-79B8-F342
ORCID iD
0000-0001-9498-8061
Researcher Id
I-7904-2018
Scopus Author Id
7402787225

Email addresses

  • manuela.ferreira@cnc.uc.pt (Professional)
  • manuela.ferreira@research.fchampalimaud.org (Professional)

Addresses

  • Champalimaud Foundation. Avenida Brasília, 1400-038 , Lisboa, Lisboa, Portugal (Professional)
  • Center for Neuroscience and Cell Biology (CNC), University of Coimbra. UC-BIOTECH, Parque Tecnologico de Cantanhede, 3060-197 , Cantanhede , Cantanhede, Portugal (Professional)

Websites

  • https://www.cnc.uc.pt/en/research-group/body-barrier-immunometabolism (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010/03/30
Concluded
 PhD in Molecular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Cancer Research UK Cambridge Research Institute, United Kingdom
"The effect of an activating beta 1 integrin mutation on skin tumours" (THESIS/DISSERTATION)
 Honours and Distinction
1998 - 2003
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Bile acid toxicity in the heart: a study with isolated heart mitocondria and cardiomyocytes" (THESIS/DISSERTATION)
 16 valores (Escala 0-20 valores)
Affiliation

Science

Category
Host institution 		Employer
2020/01/01 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/01/01 - Current Visiting Researcher (Research) Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
2017/01/01 - 2019/01/01 Postdoc (Research) Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
2010 - 2017 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2007 - 2010 Researcher (Research) Cancer Research UK Cambridge Research Institute, United Kingdom
2005 - 2007 Researcher (Research) Cancer Research UK, United Kingdom
2004 - 2005 Researcher (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
2003 - 2004 Research Trainee (Research) Universidade de Coimbra, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020/01/05 - Current Group Leader of Body Barrier Immunometabolism Laboratory (https://cnc.uc.pt/en/research-group/body-barrier-immunometabolism) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2023 - 2026/03/01 (PI) Epi_UNCOV: Unravelling how unconventional T cells are regulated by micronutrients and its role in epithelial malignancy
2022.06145.PTDC
Principal investigator
Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025/12/01 (PI) Kinder-GUT: Role of diet-derived retinoids in CD8aa intraepithelial lymphocytes and intestinal defence at early-life
HR22-00754
Principal investigator
Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal
 Fundació Caixa d' Estalvis de Catalunya
Ongoing
2018 - 2022/05 (Co-PI) EarlyMYCO-Early-life exposure to MYCOtoxins and its impact on health (Co-Principal Investigator; €239.985,56)
PTDC/MED-TOX/28762/2017
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Fundação Champalimaud, Portugal

Universidade de Évora, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2021/12 (PI) Role of diet-derived retinoids in natural intraepithelial lymphocytes and intestinal defence (Principal Investigator: €50.000,00)
IF/00425/2015/CP1324/CT0001
Principal investigator
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021/10 (PI) VitaGUT-Role of diet-derived retinoids in natural intraepithelial lymphocytes and early-life intestinal immunity (Principal Investigator: €239.989,40)
PTDC/MED-IMU/31194/2017
Principal investigator
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2020/12/31 (Post-Doc Fellow) Identification of hematopoietic subsets in lymphoid organogenesis (¿197.802,00)
PTDC/SAU-MII/100016/2008
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2019/05/31 (Post-Doc Fellow) Glia-derived factors in mucosal immune sensing (¿200.000,00)
PTDC/IMI-IMU/3138/2014
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2005 - 2006 (PI) Terry Fox Grant Unreavelling the role of bone marrow vascular compartment in myeloid leukemia (Principal Investigator: €15.000,00)
IPOLFG CIPM
Principal investigator
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
Concluded

Contract

Designation Funders
2022 - Current Assistant Researcher (CEECind - 4th Edition) - 6-year FCT Grant - Role of micronutrients in natural intraepithelial lymphocytes and intestine at early-life. (Contract established with University of Coimbra)
2021.00594.CEECIND
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2021/12 (PI) investigator FCT - Role of diet-derived retinoids in natural intraepithelial lymphocytes and intestinal defence. (Host Institution: Center for Neuroscience and Cell Biology; University of Coimbra)
IF/00425/2015 (CNC-UC)
Principal investigator
Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2020/09/30 investigator FCT - Role of diet-derived retinoids in natural intraepithelial lymphocytes and intestinal defence. (Host Institution: Champalimaud Foundation)
IF/00425/2015 (Champalimaud Foundation)
Principal investigator
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2016 PostDoc Fellowship - Role of retinoic acid in lymphoid organ development
SFRH/BPD/70195/2010
Post-doc Fellow
Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2010 PhD Fellowship - Role of ß1 integrin T188I mutation on skin tumours
SFRH/BD/11825/2003
PhD Student Fellow
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Cancer Research UK, United Kingdom
Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2003 Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?
PRODEP III-2003
 European Commission
Outputs

Publications

Conference abstract
  1. Ferreira, Manuela. "How maternal exposure to aflatoxin B1 impacts the development of progeny intestinal immune system?". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021) – Toxicology of The Next Generation. virtual congress, Maastricht, 2021.
    Published
Conference poster
  1. Ferreira, Manuela. "How maternal exposure to aflatoxin B1 impacts the development of progeny intestinal immune system?". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021) ¿ Toxicology of The Next Generation. Virtual congress, 2021.
  2. Ferreira, Manuela. "Control of natural intraepithelial lymphocytes by diet-derived retinoids". Paper presented in MICS 2018 Mucosal Immunology Course & Symposium (MICS 2018) - Oxford, United Kingdom, 2018.
  3. Ferreira, Manuela. "Control of natural intraepithelial lymphocytes by diet-derived retinoids". Paper presented in 2017 Champalimaud Research Symposium -Fundação Champalimaud - Lisbon, Portugal, 2017.
  4. Ferreira, Manuela. "Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity". Paper presented in EMBO Conference on Innate Lymphoid Cells in Paris - European Molecular Biology Conference Organization - Paris, France, 2014.
    10.1038/nature13158
  5. Ferreira, Manuela. "Maternal retinoic acid controls lymphoid tissue inducer cell differentiation and lymphoid organ size". Paper presented in EMBO Young Scientists¿ Forum at Instituto de Medicina Molecular - European Molecular Biology Organization - Lisbon, Portugal, 2013.
  6. Ferreira, Manuela. "Retinoic acid in the development of Peyer's patches". Paper presented in 7th ENII EFIS/EJI Spring school on Advanced Immunology - European Network of Immunology Institutes (ENII) - Sardinia, Italy, 2012.
  7. Ferreira, Manuela. "Retinoic acid in the development of Peyer's patches". Paper presented in XXXVII Sociedade Portuguesa de Imunologia Annual Meeting - Sociedade Portuguesa de Imunologia - Portugal, 2011.
  8. Ferreira, Manuela. "Activating T188I ß1 integrin mutation on the development of skin tumours". Paper presented in Models and Mechanisms of Cancer Symposium - Wellcome Sanger Institute - United Kingdom, 2009.
  9. Ferreira, Manuela. "Activating T188I ß1 integrin mutation on the development of skin tumours". Paper presented in Fibronectin, Integrins and related molecules - Gordon Research Conferences - United States, 2009.
  10. Ferreira, Manuela. "Activating T188I ß1 integrin mutation on the development of skin tumours". Paper presented in Genes and Cancer 2008 - University of Warwick University Bookshop - United Kingdom, 2008.
  11. Ferreira, Manuela. "The role of ß1 integrin T188I mutation on the epithelial tumour development". Paper presented in XIII International Symposium on Basement Membrane - Germany, 2007.
  12. Ferreira, Manuela. "The effect of ß1 integrin T188I mutation on the development of skin tumours". Paper presented in Keystone Symposium: Stem Cells and Cancer - Keystone Symposia - United States, 2006.
  13. Ferreira, Manuela. "Myelogenous leukemia: The contribution of the bone marrow endothelial cells on myelopoiesis". Paper presented in 1st Joint Meeting of Portuguese PhD Programmes (GABBA, PGDB and PDBEB) - Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal, 2004.
  14. Ferreira, Manuela. "Biliar acids cardiotoxicity at mitochondrial bioenergetics level". Paper presented in XXIV Portuguese Cardiology Society Congress - Madeira, Portugal, 2003.
Journal article
  1. Bruno Bernardes de Jesus; Bruno Miguel Neves; Manuela Ferreira; Sandrina Nóbrega-Pereira. "(Senior Corresponding Author) Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines (2 citations)". Cancers 12 12 (2020): 3581-3581. https://doi.org/10.3390/cancers12123581.
    10.3390/cancers12123581
  2. Goverse, G.; Labao-Almeida, C.; Ferreira, M.; Molenaar, R.; Wahlen, S.; Konijn, T.; Koning, J.; Veiga-Fernandes, H.; Mebius, R.E.. "(Co-First Author) Vitamin A controls the presence of RORgt innate lymphoid cells and lymphoid tissue in the small intestine (47 citations)". Journal of Immunology 196 12 (2016): 5148-5155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974801198&partnerID=MN8TOARS.
    10.4049/jimmunol.1501106
  3. Xu, W.; Domingues, R.G.; Fonseca-Pereira, D.; Ferreira, M.; Ribeiro, H.; Lopez-Lastra, S.; Motomura, Y.; et al. "NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors (124 citations)". Cell reports 10 12 (2015): 2043-2054. https://www.cell.com/cell-reports/fulltext/S2211-1247(15)00234-X.
    10.1016/j.celrep.2015.02.057
  4. Ferreira, M.; Veiga-Fernandes, H.. "(First Author) Pre-birth world and the development of the immune system: Mum's diet affects our adult health: New insight on how the diet during pregnancy permanently influences offspring health and immune fitness Prospects & Overviews M. Ferreira and H. Veiga-Fernandes (5 citations)". BioEssays 36 12 (2014): 1213-1220. https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.201400115.
    10.1002/bies.201400115
  5. Van De Pavert, S.A.; Ferreira, M.; Domingues, R.G.; Ribeiro, H.; Molenaar, R.; Moreira-Santos, L.; Almeida, F.F.; et al. "(Co-First Author) Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity (245 citations)". Nature 508 1 (2014): 123-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897480560&partnerID=MN8TOARS.
    10.1038/nature13158
  6. Patel, A.; Harker, N.; Moreira-Santos, L.; Ferreira, M.; Alden, K.; Timmis, J.; Foster, K.; et al. "Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems (49 citations)". Science Signaling 5 235 (2012): http://stke.sciencemag.org/content/5/235/ra55.long.
    10.1126/scisignal.2002734
  7. Ferreira, M.; Domingues, R.G.; Veiga-Fernandes, H.. "(First Author) Stroma cell priming in enteric lymphoid organ morphogenesis (7 citations)". Frontiers in Immunology 3 JUL (2012): https://www.frontiersin.org/articles/10.3389/fimmu.2012.00219/full.
    10.3389/fimmu.2012.00219
  8. Narita, M.; Young, A.R.J.; Arakawa, S.; Samarajiwa, S.A.; Nakashima, T.; Yoshida, S.; Hong, S.; et al. "Spatial coupling of mTOR and autophagy augments secretory phenotypes (345 citations)". Science 332 6032 (2011): 966-970. http://science.sciencemag.org/content/332/6032/966.long.
    10.1126/science.1205407
  9. Fujiwara, H.; Ferreira, M.; Donati, G.; Marciano, D.K.; Linton, J.M.; Sato, Y.; Hartner, A.; et al. "(Second Author) The basement membrane of hair follicle stem cells is a muscle cell niche (197 citations)". Cell 144 4 (2011): 577-589. https://www.cell.com/cell/fulltext/S0092-8674(11)00015-8.
    10.1016/j.cell.2011.01.014
  10. Cachaço, A.S.; Carvalho, T.; Santos, A.C.; Igreja, C.; Fragoso, R.; Rio, C.O.; Ferreira, M.; et al. "TNF-a regulates the effects of irradiation in the mouse bone marrow microenvironment (29 citations)". PLoS ONE 5 2 (2010): http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008980.
    10.1371/journal.pone.0008980
  11. Ferreira, M.; Fujiwara, H.; Morita, K.; Watt, F.M.. "(First Author) An activating ß1 integrin mutation increases the conversion of benign to malignant skin tumors (32 citations)". Cancer Research 69 4 (2009): 1334-1342. http://cancerres.aacrjournals.org/content/69/4/1334.long.
    10.1158/0008-5472.CAN-08-3051
  12. Young, A.R.J.; Narita, M.; Ferreira, M.; Kirschner, K.; Sadaie, M.; Darot, J.F.J.; Tavaré, S.; et al. "(3rd Author) Autophagy mediates the mitotic senescence transition (698 citations)". Genes and Development 23 7 (2009): 798-803. http://genesdev.cshlp.org/content/23/7/798.long.
    10.1101/gad.519709
  13. Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.. "(First Author) Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies? (27 citations)". Cardiovascular Toxicology 5 1 (2005): 63-73. https://www.ncbi.nlm.nih.gov/pubmed/15738586.
Newsletter article
  1. Alvito, Paula; Patricia Bastos-Amador; Elsa L. Duarte; Ferreira, Manuela; el al. "Early-life exposure to mycotoxins: the contribution of MYCOMIX and earlyMYCO projects", Boletim Epidemiológico Observações - Instituto Nacional de Saúde Doutor Ricardo Jorge, IP, 2020
Online resource
  1. Ferreira, Manuela. Co-author of Immunology Day Quiz ( SCIENCE OUTREACH). 2021. https://www.instagram.com/accounts/login/.
  2. Ferreira, Manuela. EarlyMyco: Early-life exposure to mycotoxins and its impact on health. 2019. https://www.facebook.com/EarlyMyco.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09/28 How maternal exposure to aflatoxin B1 impacts the development of progeny intestinal immune system? International Conference on Food Contaminants (ICFC) 2021 - Challenges on early-life exposure
National Institute of Health Doctor Ricardo Jorge (INSA) (Lisbon, Portugal)
2021/03/19 Fighting Infection At Body Borders: Micronutrient Immune Sensing And Early-Life Intestinal Defence Lecture under the scope of the PhD Programme (PDBEB) of Center for Neuroscience and Cell Biology of University of Coimbra -Courses 2019/2020
Center for Neuroscience and Cell Biology of University of Coimbra (Coimbra, Portugal)
2021/03/09 Micronutrient Metabolism And Innate-Like Immune System Lecture under the scope of the PhD Programme (PDBEB) of Center for Neuroscience and Cell Biology of University of Coimbra -Courses 2019/2020
Center for Neuroscience and Cell Biology of University of Coimbra (Coimbra, Portugal)
2020/11/17 Diet-Derived Retinoids Control Early Life Development of Natural TCRaß Intraepithelial Lymphocytes Key for Gut Defence Society for Mucosal Immunology - Webinar Series - Adaptive Immunity
Society for Mucosal Immunology (United States)
2020/03/10 Immune cells at body barriers: From metabolic demands to systemic metabolism Lecture under the scope of the PhD Programme (PDBEB) of Center for Neuroscience and Cell Biology of University of Coimbra -Courses 2019/2020
Center for Neuroscience and Cell Biology of University of Coimbra (Coimbra, Portugal)
2019/04/01 Neuronal-immune system crosstalk: a new paradigm in physiology. Lecture under the scope of the PhD Programme (PDBEB) of Center for Neuroscience and Cell Biology of University of Coimbra -Courses 2019/2020
PhD Center for Neuroscience and Cell Biology of University of Coimbra (Coimbra, Portugal)
2019/04 Uma viagem pela biologia epitelial e sistema imunitário Lecture under the scope of the discipline Biologia Translacional e Biomedicina, Faculdade de Ciências e Tecnologia Universidade de Coimbra
(Coimbra, Portugal)
2019/02 Role of Diet-derived Retinoids in Natural Killer-T Cell Development Champalimaud Centre for the Unknown - Internal seminars CISS
(Lisboa, Portugal)
2019/01 Micronutrient sensing and immune defense IBIMED external seminar
IBIMED Aveiro University (Aveiro, Portugal)
2018/11 How to build up the first-line immune defence in your gut? Lisbon Area PostDoctoral Meeting (LAPD Meeting)
(Lisboa, Portugal)
2017/10 Maternal Diet and baby's immune system Humanos - Onde começa a nossa Natureza - OUTREACH SCIENCE COMMUNICATION
ISCTE-Instituto Universitário de Lisboa (Cascais, Portugal)
2017/10 Control of natural intraepithelial lymphocytes and tumour development by diet-derived retinoids 2018 ESOR Symposium on Imaging Hallmarks of Cancer
Champalimaud Foundation (Lisboa, Portugal)
2017/04 O papel da nutrição no desenvolvimento sistema imunitário. Lecture on Fronteiras da Investigação em Biologia. Mestrado em Biologia Molecular e Genética, Universidade de Lisboa
Universidade de Lisboa Faculdade de Ciências e Tecnologia (Lisbon, Portugal)
2015/10 Role of diet-derived retinoids in natural intraepithelial lymphocytes XLI Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Braga, Portugal)
2014/10 Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity SPI’40 XL Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Lisboa, Portugal)
2012/11 Retinoic acid controls lymphoid tissue inducer cell differentiation XXXVIII Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Porto, Portugal)
2011/12 Cancro da pele: importante comunicar correctamente com o exterior. Ciclo de seminários: Cancro
School of Health Sciences, Politécnico de Leiria, Leiria - OUTREACH SCIENCE COMMUNICATION: (Leiria, Portugal)
2011/03 Retinoic acid in enteric lymphoid organogenesis International School of Immunology
(Tavira, Portugal)
2008/12 ß1 integrin on the development of skin tumours Research in Department of Genetics Day
University of Cambridge (Cambridge, United Kingdom)
2008/09 The impact of a ß1 integrin mutation on the progression of skin tumours Cambridge Research Institute Retreat 2008
Cambridge Research Institute, Cancer Research UK (Oxford, United Kingdom)
2007/12 ß1 integrin on skin tumours Doctoral Programme in Experimental Biology and Biomedicine (PDBEB)
Centro de Neurociências e Biologia Celular da universidade de Coimbra (Bencanta, Portugal)
2007/12 ß1 integrin T188I mutation on skin tumours Cambridge Cancer Modellers' meeting
Cambridge Research Institute, Cambridge, UK
2006/12 ß1 integrin on epidermal tumour development Annual Meeting of Centre of Neuroscience (CNC) and Doctoral Programme in Experimental Biology and Biomedicine (PDBEB)
Centro de Neurociências da Universidade de Coimbra (Cantanhede, Portugal)
2005/12 Role of the vascular compartment on bone marrow recovery post-irradiation 2nd Joint Meeting of Portuguese PhD Programmes (GABBA, PGDB and PDBEB)
(Tomar, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/05/01 - Current Post-Doctoral Project: "Unraveling the role of micronutrients in natural intraepithelial lymphocytes and intestinal defence at early-life"
Supervisor of Postdoctoral fellow Patricia Amador Bastos
Fundação Champalimaud, Portugal
2021/07/01 - 2022/09/29 MSc Project: "Unravelling the role of micronutrients in natural intraepithelial lymphocytes and intestinal defence at early-life".
Supervisor of MSc Student Júlio Manuel da Costa Alves Torres
 Molecular and Cellular Biology (Master)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/01 - 2022/07/14 BSc Project: "Unraveling the role of micronutrient in unconventional CD8aa intraepithelial lymphocytes and gut immune defense"
Supervisor of BSc Student Guilherme Silvério
 Bachelor of Science (BSc) (Degree)
Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09/01 - 2022/02/17 BSc Internship Project: "Unraveling how diet-derived retinoid signals regulate invariant natural killer T cell development"
Supervisor of BSc Student Beatriz Soares
 Bachelor of Science (BSc) (Degree)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02/15 - 2021/06 BSc Internship Project: "The role of Hes1 in retinoic acid signaling-dependent invariant NKT cell development."
Supervisor of BSc Student Beatriz Simões Neves
 Bachelor of Science (BSc) (Scientific initiation)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/10/01 - 2019/11/20 MSc Project: "Micronutrients impact on Invariant Natural Killer T (iNKT) cells development and function."
Supervisor of MSc student Ana Raquel da Palma Coelho Pessoa da Silva
 Immunology (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/09 - 2015/09 MSc Project: "Role of diet-derived retinoids in natural intraepithelial lymphocytes".
Supervisor of MSc Student Bruno Belchior Raposo
 Biologia Molecular e Genética (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/08/01 - 2022/09/30 SUMMER WITH SCIENCE - 2022 - Preparation of Institutional (CIBB/CNC) application for FCT call. Part of a 3-people committee that selected and awarded 29 student applicants with Scientific Research Initiation Grants. Invited speakers and organized weekly seminars that were presented to grantees in September 2022. (2022/08/01 - 2022/09/30)
Call (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/29 - 2021/01/29 CNC Seminars: Metabolic signaling in cancer and cell plasticity (2021/01/29 - 2021/01/29)
Seminar (Co-organisor)
 Centro de Neurociências e Biologia Molecular da Universidade de Coimbra, Portugal
2020/09/25 - 2020/09/25 SYMPOSIUM: 1st Symposium of Early Life Exposure to Mycotoxins and Health Impact. (2020/09/25 - 2020/09/25)
Conference (Co-organisor)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/04/12 - Current MENTORSHIP PROGRAM: Mentee in the Early Career Mentorship Program (Mentor: Dr. Gerard Éberl, Institut Pasteur) (Society for Mucosal Immunology, SMI)
Other
 SMI Mentorship Program
Society for Mucosal Immunology, United States
2021/12/26 - 2022/01/06 EXPRESSION of INTEREST: Portuguese Flow Cytometry Network - PT-FlowCyt: Application Preparation for Expression of Interest regarding the National Roadmap for Research Infrastructures (RNIE) FCT Call.
Call
 Expression of Interest National Roadmap for Research Infrastructures (RNIE) FCT Call
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/09 - 2019/01/11 COURSE: Certificate to design animal procedures and projects in Bioscience & Biomedical Experiments (Function B). Federation of European Laboratory Animal Science Associations (FELASA). Training School in Experimental Design & Statistical Analysis of Bioscience & Biomedical Experiments.
Other
 Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham University
Federation of European Laboratory Animal Science Associations (FELASA), United Kingdom
2018/02 - 2018/02 WORKSHOP: Ferreira M. presented her experience in attracting funding.
Workshop
 Grant Writing, 6th Science Careers Workshop
Fundação Champalimaud, Portugal
2014/02 - 2014/02 OUTREACH SCIENCE ACTIVITY: Ferreira M. presented an overview of her host laboratory research to students of Medicine FMUL
Exhibition
 Dia da Investigação na FMUL
Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2008/05 - 2008/05 OUTREACH SCIENCE ACTIVITY: Ferreira M. participated in science exhibition and guided tour around the Cambridge Research Institute, Cancer Research UK, for general public and fundraising people
Exhibition
 Open day at CRUK in Cambridge Research Institute
Cancer Research UK Cambridge Research Institute, United Kingdom
2007/06 - 2007/06 OUTREACH SCIENCE ACTIVITY: Ferreira M. participated in Cambridge Science Festival (UK) sharing skin biology knowledge and raise awareness of the health risks for skin cancer. Engagement of general public for science.
Festival
 Cambridge Science Festival (UK)
Cambridge City Council, United Kingdom
2006/09 - 2006/09 COURSE: License to perform animal experimentation (Function A) by Royal Society of Biology and Home Office Function. Certificate given then in Portugal by DGAV
Other
 Animal Experimentation Course
The Royal Society of Biology, United Kingdom

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/09/26 Master Thesis entitled: "Determinants of progression and screening of Monoclonal B-cell lymphocytosis."
(Thesis) Main arguer
 Luana Isabel Sadio Carretas (Master)
Universidade de Coimbra, Portugal
2021/12/09 Master Thesis entitled: "Molecular insights into the role of FoxN1 in thymic epithelial cell development and function: generation of a platform for T-cell development through FoxN1-induced cell reprogramming."
(Thesis) Main arguer
 Nuno André Roque David (Master)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/11/16 Master Thesis entitled: Peripheral immune status of trabectedin versus anthracycline- based chemotherapy in soft tissue sarcoma
(Thesis) Main arguer
 Luana Madalena Oliveira da Silva de Sousa (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2021/02/16 Master Thesis entitled: "Identification of reagents intended to the study of the long isoform of the NF-YA transcription factor"
(Thesis) Main arguer
 Bárbara Filipa Teixeira De Araújo Miranda (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2020/12/14 Master Thesis entitled: "Thymic natural killer cells as mediators of cell competition".
(Thesis) Main arguer
 Marta Faro Craveiro Nogueira (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/01 Master Thesis entitled: "Long non-coding RNA contribute to direct conversion reprogramming."
(Thesis) Main arguer
 António Duarte Zapico Bicho de Sousa Franco (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/01/21 - Current Nature Immunology (1529-2908) Springer Nature Limited
2020/10/18 - Current European Journal of Clinical Investigation (1365-2362) Willey

Association member

Society Organization name Role
2018 - Current Society for Mucosal Immunology Member
2010 - Current Portuguese Society of Immunology Member
2003 - 2005 Portuguese Biochemical Society Member

Committee member

Activity description
Role 		Institution / Organization
2021/07/27 - Current PhD Thesis Committee of the student Susana Costa from the course of PhD in Experimental Biology and Biomedicine
Advisor / Consultant
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/07/13 - Current PhD Thesis Committee of the student Luís Filipe Fragoso Grilo from the course of PhD in Experimental Biology and Biomedicine
Advisor / Consultant
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/07/03 - Current PhD Thesis Committee of the student Luís Filipe Henriques Oliveira from the course of PhD in Experimental Biology and Biomedicine
Advisor / Consultant
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/05/01 - 2017/05/02 Meeting session chair: PhD Student Annual Meeting. Session chairing. Instituto de Medicina Molecular, Lisbon
Member
 Instituto de Medicina Molecular, Portugal

Mentoring / Tutoring

Topic Student name
2021/11/01 - 2022/07/15 Graduated Voluntary Internship: "Understanding how dietary factors shape innate-like lymphocytes" (9 months) Soraia R. J. Faria - Bachelor Degree in Biotecnology Escola Superior Agrária de Coimbra - IPC
2022/04/04 - 2022/05/04 MSc student - Lab Rotation (1 month) Mafalda Penetra - Master's in Medicinal Chemistry - FCTUC - University of Coimbra
2022/03/07 - 2022/04/08 MSc student - Lab Rotation (1 month) Mariana Miranda - Master Degree in Biomedical Research FMUC- University of Coimbra
2022/02/02 - 2022/02/28 MSc student - Lab Rotation (1 month) Henrique J. Santos - Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2021/07/01 - 2021/09/02 Undergraduated Voluntary Internship: "Unravel How Diet-derived Retinoid Signals Regulate Invariant Natural Killer T Cell Development" (2 months) Beatriz Soares - Bachelor degree in Biology FCTUC - University of Coimbra
2021/05/01 - 2021/05/31 MSc student - Lab Rotation (1 month) Afonso Ruivo - Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2020/12/01 - 2021/02/25 MSc student -Lab Rotation (2 months) Guilherme Faria - Master Degree in Biomedical Research FMUC- University of Coimbra
2021/01/01 - 2021/02/04 MSc student -Lab Rotation (1 month) Júlio Torres - Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2021/01/01 - 2021/02/04 MSc student - Lab Rotation (1 month) Luiz Felipe Piochi Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2021/01/01 - 2021/01/29 MSc student -Lab Rotation (1 month) Eze Great Ogwu - Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2020/02/10 - 2020/02/28 MSc student -Lab Rotation (1 month) Filipe Mateus - Master degree in Biomedical Research FMUC- University of Coimbra
2020/02/03 - 2020/02/28 MSc student - Lab Rotation (1 month) Nuno David - Master degree in Cellular and Molecular Biology FCTUC - University of Coimbra
2017/01/03 - 2018/03/01 PhD student - Unravelling the role of diet retinoids on the development of NKT cells Sílvia Arroz Madeira - Instituto de Medicina Molecular João Lobo Antunes - Lisbon, PT
2015/01/03 - 2016/09/01 PhD student - Role of retinoic acid-regulated NKT in melanoma Farzaneh S. Mirfakhar - Instituto de Medicina Molecular João Lobo Antunes, Lisbon, PT
2014/06/01 - 2015/07/04 MSc student - Role of diet-derived retinoids in natural intraepithelial lymphocytes Carlos Almeida - Instituto de Medicina Molecular João Lobo Antunes, Lisbon. PT
2012/02/01 - 2012/06/02 MSc student - Role of diet-derived retinoids in development of lymphoid organs Ioana Posa - Instituto de Medicina Molecular João Lobo Antunes, Lisbon. PT
2009/01/03 - 2010/03/01 PhD student - The effect of ß1 integrin T188I mutation on the development of skin tumours Marta Lesko - Cancer Research UK, Cambridge. UK

Other jury / evaluation

Activity description Institution / Organization
2022/01/18 - 2022/01/19 Member of Scientific Committee for the Bluepharma Award 2022 - Best poster Doctoral Program in Experimental Biology and Biomedicine (PD-BEB) - ( 16th edition of BEB Day 2022: The overview effect) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/01/14 - 2022/01/14 Evaluation of Laboratorial Rotation of MSc student: "Kinases and phosphatases involved in direct reprogramming of fibroblasts into type 1 dendritic cells." Name of the student: Renata Filipa Coelho e Castro. (Laboratory of Carlos Filipe Pereira - Cell Reprogramming and Immunity Lab) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Distinctions

Award

2021 2021 Young Investigator Award for Excellence in Basic/Translational Research
European Society for Clinical Investigation, Netherlands
2018 Young Investigator Travel Award (Society for Mucosal Immunology - USA)
Society for Mucosal Immunology, United States
2014 Travel Grant - Sociedade Portuguesa de Imunologia (SPI)
Sociedade Portuguesa de Imunologia, Portugal
2014 Best Paper of the Year Award - Sociedade Portuguesa de Imunologia (SPI)
Sociedade Portuguesa de Imunologia, Portugal
2013 EMBO Prize Poster Award
European Molecular Biology Organization, Germany
2005 Terry Fox Research Award
Liga Portuguesa Contra o Cancro, Portugal

Other distinction

2022 Honorable Mention by Maratona da Saúde (June 2022)
Maratona da Saúde, Portugal
2021 Assistant Researcher (CEEC - 4th Edition) - 6-year FCT Grant. Final classification of 9,05/10 (ranked in Top-10 of 93 applicants evaluated by the Basic and Clinical Medicine international panel).
Fundação para a Ciência e a Tecnologia, Portugal
2021 Early Career Mentorship Program (Society for Mucosal Immunology - USA)
Society for Mucosal Immunology, United States
2015 FCT Investigator Program Award. 5-year starting grant with Exploratory Budget (50K€). Final classification of 9,0/9,0 (ranked #3 out of 71 applicants evaluated by the Medical & Health Sciences Panel).
Fundação para a Ciência e a Tecnologia, Portugal
2010 Post-Doctoral fellowship from the Foundation for Science and Technology.
Fundação para a Ciência e a Tecnologia, Portugal
2005 Doctoral fellowship from the Foundation for Science and Technology.
Fundação para a Ciência e a Tecnologia, Portugal