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Inês Albino holds a PhD in Experimental Biology and Biomedicine (University of Coimbra, 2025). Her doctoral research, developed within the framework of the NANOSTEM Marie Sklodowska-Curie ITN and later supported by an FCT PhD Fellowship, focused on the engineering of extracellular vesicle-based nanoformulations for targeted delivery across the blood-brain barrier. She designed a novel extracellular vesicle formulation functionalized via bioconjugate chemistry to target the brain endothelium, refining key formulation parameters to optimize functionalization efficiency, colloidal stability, and biological performance. Her work further elucidated the mechanisms underlying the interaction and transport of engineered vesicles across the blood-brain barrier. She obtained a master’s degree in Biomedical Engineering (University of Twente, 2017), where she developed supported lipid-bilayer (SLB) biointerfaces as bioactive surfaces to modulate endothelial cell adhesion. Her thesis applied supramolecular chemistry principles to functionalize SLBs with specific integrin and cadherin ligands, offering new insights into the design of biomimetic platforms for tissue engineering and cell–material interaction studies. In 2016, she joined the Molly Stevens Group at the Karolinska Institute, where she gained expertise in polymer chemistry, peptide synthesis, RAFT polymerization, and click reactions, focusing on polymeric drugs with highly selective cell-surface binding. Inês earned her bachelor’s degree in Biomedical Engineering (Escola Superior de Biotecnologia – Universidade Católica Portuguesa, 2014). During her studies, she participated in multidisciplinary projects and conducted her first research in analytical chemistry, leading to an oral communication at the 18th International Conference on Flow Injection Analysis (Royal Society of Chemistry). Following an exchange at the University of Twente, she completed her bachelor thesis on the cadherin switch (N-cadherin to cadherin-11) during osteogenic differentiation, bridging developmental biology with bone tissue engineering and sparking her long-term interest in regenerative medicine and the development of biomimetic nanotherapeutics.
Identification

Personal identification

Full name
Inês Maria Cunha Albino

Citation names

  • Albino, Inês

Author identifiers

Ciência ID
B41F-F947-11C8
ORCID iD
0000-0002-9451-0831

Email addresses

  • inesmalbino@gmail.com (Professional)

Telephones

Mobile phone
  • 918972518 (Personal)

Addresses

  • UC-Biotech. Nucleo 4, Lote 8, 3060 197 , Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2018/09/01 - 2025/07/02
Concluded
Programa Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
"New platforms for brain targeting and modulation" (THESIS/DISSERTATION)
2017
Concluded
Biomedical Engineering - Bionanotechnology & Advanced Manufacturing (Master)
Universiteit Twente, Netherlands
"Exploring Lipid Bilayer Biointerfaces to Study Cell-Cell Interactions with Endothelial Cells" (THESIS/DISSERTATION)
8 (0-10)
2014
Concluded
Bioengenharia (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Identification of Cadherins Present in Mesenchymal Stem Cells on Calcium Phosphate Ceramics and the Timing of The Cadherin Switch" (THESIS/DISSERTATION)
15 (0-20)
Affiliation

Others

Category
Host institution
Employer
2018/09/01 - 2025/07/02 PhD Student: Engineered Extracellular Vesicles for Targeted Brain Delivery Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/28 - 2019/11/30 PhD Secondee at QMUL: Biophysical characterization of EVs surface interactions, stability and protein fouling Queen Mary University of London, United Kingdom
Queen Mary University of London, United Kingdom
2018/01/01 - 2018/09/01 Master Student Fellow: Development of therapies to tackle cardiovascular disorders, particularly to improve survival of transplanted cells, in cell therapies. Universidade de Coimbra Faculdade de Medicina, Portugal
2016/10/01 - 2017/08/01 Master Student: Exploring Lipid Bilayer Biointerfaces toStudy Cell-Cell Interactions with Endothelial Cells Universiteit Twente, Netherlands
2016/05/01 - 2016/09/01 Intern Student: Development of multivalent peptide-polymer conjugates intended to mimic the activity of tumor necrosis factor related apoptosis (TRAIL) for the treatment of breast cance Karolinska Institutet, Sweden
Projects

Contract

Designation Funders
2018/09/01 - 2022/02/28 NANOSTEM ITN - Developing new NANOmaterials for neural STEM cells drug delivery
PhD Student Fellow
Queen Mary University of London, United Kingdom

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Université d'Artois, France

Karolinska Institutet, Sweden

Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Germany

MJR PHARMJET, Germany

Sanofi SA Recherche & Développement, France

HCSPharma, France
European Commission
Concluded
2018/05/01 - 2018/08/31 COMBINATORIAL APPROACHES TO PROMOTE CELL SURVIVAL - PROSURVIVAL
PTDC/BIM-MED/1118/2012
Master Student Fellow
Outputs

Publications

Conference paper
  1. Albino, Inês; Lino, Miguel; Ferreira, Lino. "Improved Uptake of Extracellular Vesicles in Ischemia". Paper presented in 31st Conference of the European Society for Biomaterials (ESB), Porto, 2021.
    Accepted
Conference poster
  1. Albino, Inês; Ambrosetti, Elena; Teixeira, Ana; Lino, Miguel; Ferreira, Lino. "Engineered extracellular vesicles for brain targeting". Paper presented in 3rd RESETageing Conference, 2023.
  2. Albino, Inês; Ambrosetti, Elena; Teixeira, Ana; Lino, Miguel; Ferreira, Lino. "Engineered extracellular vesicles for brain targeting". Paper presented in Annual Meeting of the European Tissue Repair Society (ETRS) and the Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), 2023.
  3. Lino, Miguel; Catapano, Francesco; Albino, Inês; Emanueli, Costanza; Ferreira, Lino. "Engineered extracellular vesicles targeting ischemic endothelial cells". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
Journal article
  1. João André Sousa; Catarina Bernardes; Sara Bernardo-Castro; Miguel Lino; Inês Albino; Lino Ferreira; José Brás; et al. "Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target". Frontiers in Aging Neuroscience (2023): http://dx.doi.org/10.3389/fnagi.2023.1102809.
    10.3389/fnagi.2023.1102809
  2. Federico Traldi; Pengfei Liu; Inês Albino; Lino Ferreira; Ali Zarbakhsh; Marina Resmini. "Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032810.
    10.3390/ijms24032810
  3. Gülistan Koçer; Inês M.C. Albino; Mark L. Verheijden; Pascal Jonkheijm. "Endothelial cell spreading on lipid bilayers with combined integrin and cadherin binding ligands". Bioorganic & Medicinal Chemistry 68 (2022): 116850-116850. http://dx.doi.org/10.1016/j.bmc.2022.116850.
    10.1016/j.bmc.2022.116850
  4. Hugo Fernandes; Alessandra Zonnari; Ricardo Abreu; Sezin Aday; Marta Barão; Inês Albino; Miguel Lino; et al. "Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration". Molecular Therapy - Nucleic Acids 28 (2022): 307-327. http://dx.doi.org/10.1016/j.omtn.2022.03.018.
    10.1016/j.omtn.2022.03.018
  5. Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino. "Engineered extracellular vesicles as brain therapeutics". Journal of Controlled Release 338 (2021): 472-485. https://doi.org/10.1016/j.jconrel.2021.08.037.
    Open access • 10.1016/j.jconrel.2021.08.037
  6. Sara Bernardo-Castro; Inês Albino; Ángela María Barrera-Sandoval; Francesca Tomatis; João André Sousa; Emanuel Martins; Susana Simões; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. https://doi.org/10.3390/life11060482.
    10.3390/life11060482
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/09 NANOSTEM End of Network Meeting: Engineered Extracellular Vesicles for Brain Targeting and Modulation NANOSTEM End of Network Meeting
2020/07/07 2nd NANOSTEM International Meeting: Engineered extracellular vesicles for stroke therapy 2nd NANOSTEM Scientific Meeting
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2019/07/02 1st NANOSTEM International Meeting: Exploring new strategies for brain endothelium targeting 1st NANOSTEM Scientific Meeting
Queen Mary University of London (United Kingdom)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2020/07/13 - 2020/07/17 2nd NANOSTEM International Meeting (2020/07/13 - 2020/07/17)
Conference (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/06/28 - 2019/06/29 Conference – Ageing: models, mechanisms and therapies (2019/06/28 - 2019/06/29)
Conference (Member of the Organising Committee)
Universidade de Coimbra Faculdade de Medicina, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/09/27 - 2019/09/27 European Researchers' Night: Event to the general public with ~1000 participants, in the Botanical gardens, Coimbra
2019/03/30 - 2019/03/30 Dia Nacional do Doente com AVC - 5ª Caminhada Comemorativa/Stroke awareness walk in Coimbra downtown: Event to the general public with ~100 participants.
2019/03/18 - 2019/03/18 Escola Ciência Viva: Event targeted at Primary school students with ~30 participants, at the University of Coimbra.
2018/10/04 - 2018/10/04 Festival de Ciência, Oliveira do Bairro: Event to a young audience, with ~8000 participants, in Centro de exposições, Oliveira do Bairro.
2018/09/28 - 2018/09/28 European Researchers' Night: Event to the General public, with ~1000 people participants, in the Botanical gardens, Coimbra
Distinctions

Award

2012 Bolsa de mérito ano lectivo 2011/2012
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2011 Bolsa de mérito ano lectivo 2012/2013
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal