???global.info.a_carregar???
Ana Laura Dias earned her Bachelor's degree in Biochemistry from the NOVA School of Science and Technology in 2019 and completed her Master's degree in Pharmaceutical Chemistry at the Faculty of Pharmacy, University of Porto, in 2021. She has engaged in research as part of the FCT project "Sustainable antifouling agents: from grape wastes to the sea with green chemistry leading the way" (PTDC/CTA-AMB/0853/2021), for which she received a research fellowship in 2022 (2022-002-BI-M_CTA-AMB). Currently, Ana Laura is a PhD student at the Faculty of Pharmacy, University of Lisbon, funded by an FCT national studentship (2022.09827.BD). Her thesis, "Exploitation of a scorpion-derived alkaloid for drug discovery," employs techniques from machine learning, synthetic chemistry, and chemical biology as a multidisciplinary approach to explore the potential of an unexplored scorpion-derived natural product in pharmaceutical applications.
Read full resume ↓
Identification

Personal identification

Full name
Ana Laura Menoita da Costa Dias

Citation names

  • Dias, Ana Laura
  • Ana Laura Dias

Author identifiers

Ciência ID
B31A-3CB2-8FB3
ORCID iD
0000-0002-8933-0780

Email addresses

  • ana.laura.dias@edu.ulisboa.pt (Professional)

Telephones

Telephone
  • 914645758 (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Cell Biology
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Affiliation

Science

Category
Host institution 		Employer
2022/03/16 - 2022/09/15 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2022/03/16 - 2022/09/15 Anti-incrustantes sustentáveis: dos desperdícios da uva para o Mar, com a Química Verde a liderar o caminho.
PTDC/CTA-AMB/0853/2021
Research Fellow
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Ana Laura Dias. "MACHINE LEARNING IN PROTEIN TARGET DISCOVERY AND DERIVATIVE SYNTHESIS OF AN UNEXPLORED NATURAL PRODUCT". Paper presented in Poster presentation - XXVIII EFMC International Symposium on Medicinal Chemistry and 11th EFMC Young Medicinal Chemists' Symposium, 2024.
  2. Ana Laura Dias. "Leveraging Machine Learning for Protein Target Discovery in Natural Products". Paper presented in Poster presentation - X Iberoamerican Congress of Pharmaceutical Sciences, 2023.
  3. Ana Laura Dias; Cravo, Sara; Soares, José; Madalena M. M. Pinto; Afonso, Carlos; Correia-da-Silva, Marta. "Eco-friendly synthesis of a new antifouling agent: one step towards the scale-up process". Paper presented in Blue Think Conference, 2022.
  4. Afonso, Inês; Daniela R. P. Loureiro; Ana Laura Dias; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "Synthesis of analogues of a hit antitumor pyranoxanthone". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  5. Ana Laura Dias; Daniela R. P. Loureiro; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "A novel palladium-catalyzed synthetic route to obtain a key xanthonic chemical precursor of potential antitumor pyranoxanthones". Paper presented in XXVII Encontro Nacional Sociedade Portuguesa de Química, 2021.
Journal article
  1. Libby Brown; Aldrin V. Vidal; Ana Laura Dias; Tiago Rodrigues; Anna Sigurdardottir; Toby Journeaux; Siobhan O’Brien; et al. "Proximity-driven site-specific cyclization of phage-displayed peptides". Nature Communications (2024): https://doi.org/10.1038/s41467-024-51610-4.
    10.1038/s41467-024-51610-4
  2. Yanira Méndez Gómez; Aldrin Vasco Vidal; Galway Ivey; Ana Laura Dias; Peter Gierth; Bárbara B. Sousa; Claudio D. Navo; et al. "Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process". Angewandte Chemie International Edition 62 44 (2023): http://dx.doi.org/10.1002/anie.202311186.
    10.1002/anie.202311186
  3. Ana Laura Dias; Latimah Bustillo; Tiago Rodrigues. "Limitations of representation learning in small molecule property prediction". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-41967-3.
    10.1038/s41467-023-41967-3
  4. Soares, José X.; Loureiro, Daniela R. P.; Dias, Ana Laura; Reis, Salete; Pinto, Madalena M. M.; Afonso, Carlos M. M.. "Bioactive Marine Xanthones: A Review". Marine Drugs 20 1 (2022): 58. http://dx.doi.org/10.3390/md20010058.
    Open access • 10.3390/md20010058
Thesis / Dissertation
  1. Ana Laura Menoita da Costa Dias. "Synthesis of 4-hydroxyxanthone, a key precursor for antitumor pyranoxanthones". Master, Universidade do Porto Faculdade de Farmácia, 2021. https://hdl.handle.net/10216/138049.
  2. "Estudos Estruturais da a-Sinucleína sob a Influência de Metabolitos Comuns". Degree, Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/05/08 Integrating machine learning in protein target discovery and natural product optimization 5th Meeting of Young Biophysicists 8-9th May 2025 (Flash Presentation)
Portuguese Young Biophysicists (PYBphy) (Lisboa, Portugal)
2024/08/30 Benchmarking traditional and deep learning models for protein target activity prediction GP2A 2024 - 32nd Annual GP2A Medicinal Chemistry Conference
University of Coimbra (Coimbra, Portugal)
2023/11/23 From traditional algorithms to deep learning: evaluating machine learning models for drug target identification XXVII Encontro Luso Galego de Química
Sociedade Portuguesa de Química (Porto, Portugal)
Distinctions

Award

2021 Estudante que concluiu a Licenciatura em Bioquímica com a classificação mais elevada no ano letivo de 2018/19
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 Prémio melhor estudante de Ciências, melhor estudante dos cursos de Ciências (Licenciaturas e Mestrados Integrados) no ano letivo 2018/19
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 NOVA Young Talent Awards
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal