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Identification

Personal identification

Full name
Rita Pereira Vilaça

Author identifiers

Ciência ID
B317-85CF-B04B

Addresses

  • LAQV-REQUIMTE - Faculty of Sciences University of Porto, Rua do Campo Alegre, s/n, 4169-007, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
Education
Degree Classification
2009/01/01 - 2014/05/28
Concluded
Ciências Biomédicas (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Interplay between sphingolipid and nutriente signaling in niemann-pick type C1 disease: new clues from a yeast cell model" (THESIS/DISSERTATION)
Aprovado com distinção
Projects

Other

Designation Funders
2023/10 - Current Future of plant-based food: Bridging the gap of new proteins and FLAVOURsome (FLAVOURsome)
WG5 member
REQUIMTE LAQV Porto, Portugal
European Cooperation in Science and Technology
Ongoing
Outputs

Publications

Conference poster
  1. Vilaça, Rita; Barros, Ivo; Matmati, Nabil; Silva, Elísio; Teixeira, Vitor; Hannun, Yusuf A.; Costa, Vítor. "The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in the yeast model of Niemann-Pick type C1". Paper presented in Gordon Research Conference ¿Lysosomal Diseases¿, 2017.
  2. Martins, Telma S.; Pereira, Clara; Teixeira, Vitor; Vilaça, Rita; Moradas-Ferreira, Pedro; Costa, Vítor. "Activation of the transcriptional regulator Aft1p underlies iron accumulation in cells lacking the sphingomyelinase Isc1p". Paper presented in XIX Congresso Nacional de Bioquímica, 2016.
  3. Vilaça, Rita; Silva, Elísio; Sá-Miranda, Clara; Costa, Vítor. "Deletion of Niemann -Pick type C1 related gene decreases yeast lifespan associated with mitochondrial dysfunctions". Paper presented in Redox signaling and oxidative stress in health and disease, 2012.
  4. Vilaça, Rita; Balreira, Andrea; Sá-Miranda, Clara; Costa, Vítor. "The Niemann-Pick type C1 protein function is essential for lifespan". Paper presented in VIII International Symposium of Sociedade Portuguesa de Doenças Metabólicas, 2011.
  5. Vilaça, Rita; Gaifém, Joana; Moradas-Ferreira, Pedro; Sá-Miranda, Clara; Costa, Vítor. "The Niemann-Pick type C1 protein plays a key role in redox homeostasis and lifespan". Paper presented in 18th workshop of the European Study Group on Lysosomal Diseases, 2011.
Online resource
  1. Vilaça, Rita. PhasAGE News Blog. 2021. https://phasage.eu/news/.
Preprint
  1. Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla. "Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease". 2022. http://dx.doi.org/10.1101/2022.02.13.480262.
    10.1101/2022.02.13.480262

Artistic / Performance

Artistic exhibition
  1. E217-41D1-AFDB; 051F-7410-70CA; Vilaça, Rita. Um Olhar Raro. 2023.
Video recording
  1. Vilaça, Rita. 2024. PhasAGE Ask The Expert Series | Salvador Ventura.
    10.5281/zenodo.10776772
  2. Vilaça, Rita. 2024. PhasAGE Ask The Expert Series | Peter Tompa.
    10.5281/zenodo.10777590
  3. Vilaça, Rita; BB10-98AA-9F22; C11F-C5F4-5DB8. 2024. PhasAGE Ask The Expert Series | Silvio Tosatto.
    10.5281/zenodo.10722947

Other

Research technique
  1. PhasAGE Training School 2 - Experimental analysis of FUS liquid-liquid phase separation with INCell and Synergy 2 -Practical session Protocol. Co-Researcher. Vilaça, Rita; 051F-7410-70CA. 2022.
    10.5281/zenodo.7143001 • Co-Researcher
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/08 Iron overload impairs autophagy and decreases lifespan in the yeast model of Niemann-Pick type C1 47th FEBS Congress - “Together in bioscience for a better future”
(Tours, France)
2022/12/11 Uncovering the Liquid-Liquid Phase Separation Behavior of Ataxin-3 II PhasAGE-VIB International Conference
VIB (Brussels, Belgium)
2021/06/09 Extracellular vesicles from fibroblasts of Huntington's Disease patients are involved in the transfer of mitochondrial components ESCI 55TH ANNUAL SCIENTIFIC MEETING
European Society for Clinical Investigation
2021/06/09 Fibroblasts-derived extracellular Vesicles Revert Synaptic Dysfunction in Human Huntington's Disease Striatal Neurons ESCI 55TH ANNUAL SCIENTIFIC MEETING
European Society for Clinical Investigation
2021/05 Extracellular vesicles cargo as biomarker of mitochondrial dysfunction in Huntington’s Disease 10th Annual Meeting ISEV 2021 - Virtual
International Society for Extracellular Vesicles

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2022/09 - 2023/07/14 Characterization of the neuroprotective effect of anti-aggregation molecules in a Drosophila model of Machado-Joseph Disease
Supervisor of Ana Mafalda da Costa Silva Claro
Mestrado em Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2022/11/15 Yck2: At The Intersection Of Prion-like Domains And Stress Granules Regulation?
Co-supervisor
Mestrado em Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2022/07/21 Uncovering the Liquid-Liquid Phase Separation Behavior of Ataxin-3
Co-supervisor
Mestrado em Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2021 - 2021 Role of TFEB in autophagy in cell models of Huntington’s disease
Supervisor
Engenharia Biomédica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 The role of eisosomes and calcineurin in a yeast model of Niemann-Pick type C1
Supervisor
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/02/26 - 2024/02/28 TRAINING SCHOOL "Databases and computational tools on phase separation". Participants will receive multidisciplinary training to gain deeper insights and practical experience in applying databases, in silico resources and computational tools to query relevant biological data and analyze it in context. Using integrative methodologies for studying both structured and intrinsically disordered proteins, trainees will investigate the LLPS and aggregation propensities of wild-type and mutant proteins in physiology and disease. (2024/02/26 - 2024/02/28)
Workshop (Member of the Organising Committee)
Vrije Universiteit Brussel, Belgium

Vlaams Instituut voor Biotechnologie, Belgium
2023/10/18 - 2023/10/20 III PhasAGE International Conference "Multiscale understanding of protein aggregation and biomolecular condensates in aging and disease" https://phasage.eu/iii-phasage-international-conference/ (2023/10/18 - 2023/10/20)
Conference (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09/15 - 2023/10/20 Exposição “Um olhar raro” A iniciativa visa agregar, em simultâneo, a perspectiva dos doentes, de jovens alunos de escola secundária e de investigadores sobre um grupo de doenças genéticas raras e incuráveis; a exposição integrará fotografias tiradas pelos próprios pacientes e/ou seus cuidadores; ilustrações gráficas de estruturas de proteínas envolvidas nas doenças raras; e representações gráficas feitas por alunos do ensino secundário sobre a relação da estrutura e função de proteínas e o seu papel em doenças humanas raras. (2023/09/15 - 2023/10/20)
Exhibition (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09/15 - 2023/09/15 Capacity building event aimed to empower the capabilities of national associations of patients with neurodegenerative and neuromuscular diseases. https://phasage.eu/capacity-building-event-to-empower-patients-associations-dedicated-to-neurodegenerative-and-neuromuscular-diseases-in-porto/ (2023/09/15 - 2023/09/15)
Symposium (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/04/17 - 2023/04/21 Training School "Protein aggregation, intrinsic disorder and phase separation in the era of machine learning" - The main goal of this course is to provide multidisciplinary training on computational and experimental tools to acquire comprehensive knowledge of integrative methodologies for studying intrinsically disordered proteins and protein aggregation in cell biology and disease. (2023/04/17 - 2023/04/21)
Workshop (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/12/11 - 2022/12/13 PHASAGE-VIB INTERNATIONAL CONFERENCE "Biomolecular condensates in biology and disease" https://phasage.eu/ii-phasage-international-conference/ (2022/12/11 - 2022/12/13)
Conference (Member of the Organising Committee)
Vlaams Instituut voor Biotechnologie, Belgium

Vrije Universiteit Brussel, Belgium

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/10/19 - Current Training Course in Research Ethics & Integrity
Workshop
Training Course in Research Ethics & Integrity (57 hours training)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09 - Current Preparation and implementation of science education activities for i3S educational program (https://cienciaetal.i3s.up.pt/?page_id=5452) to high school students - Workshop "From 3D structure to protein function".
Workshop
i3S educational program
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/08/21 - 2023/08/23 Design Thinking
Workshop
Skills and Lead, Portugal
2022/01/13 - 2022/01/21 Triggers and Trends in Communicating Science for Society
Workshop
Workshop Triggers and Trends in Communicating Science for Society (40 hours training)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/29 - 2021/10/11 Research Project Management Course
Workshop
Research Project Management Course, 1st edition (20 hours training)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/24 - 2021/09/24 Preparation and implementation of science communication activities for European Researcher's Nights (supported by Marie Sklodowska-Curie Actions) which are public events dedicated to bringing researchers closer to the public. "A DESORDEM NA FUNÇÃO CEREBRAL E DOENÇAS ASSOCIADAS AO ENVELHECIMENTO - PhasAGE Twinning Project"
Workshop
European Researcher's Night 2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/12/10 Aggregation and toxicity of seipin/BSCL2 N88S mutant associated with motor neuron degeneration
(Thesis) Main arguer
Verónica Andrade Nogueira (Master)
Universidade do Porto Faculdade de Ciências, Portugal