Identification
Personal identification
- Full name
- Sérgia Velho
- Gender
- Female
Citation names
- VELHO, SERGIA
Author identifiers
- Ciência ID
- B316-B47C-2855
- ORCID iD
- 0000-0002-7104-8234
- Google Scholar ID
- qmAvPh0AAAAJ&hl
- Scopus Author Id
- 8738558400
Email addresses
- svelho@ipatimup.pt (Professional)
Telephones
- Telephone
-
- 226074900 (Professional)
Addresses
- Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)
Websites
- https://www.i3s.up.pt/content/people?id=166&idg=17 (Professional)
Knowledge fields
- Medical and Health Sciences - Clinical Medicine - Oncology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | |
German | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) | |
Spanish; Castilian | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) |
Education
Degree | Classification | |
---|---|---|
2006 - 2010
Concluded
|
Human Biology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"The role of BRAF and KRAS activating mutations in deficient and proficient MMR colorectal carcinomas." (THESIS/DISSERTATION)
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Approved |
1999 - 2003
Concluded
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Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Screening of germline mutations in members of the ERM family in HDGC." (THESIS/DISSERTATION)
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15 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019 - Current | Auxiliary Researcher (Research) | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2014 - 2019 | Auxiliary Researcher (Research) | Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal |
2011 - 2013 | Postdoc (Research) | Massachusetts General Hospital Cancer Center, United States |
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2017 - 2019 | Invited Adjunct Teacher (Polytechnic Teacher) | Instituto Politécnico do Porto Escola Superior de Saúde, Portugal |
2017 - 2018 | Invited Assistant (Polytechnic Teacher) | Instituto Politécnico do Porto, Portugal |
Projects
Contract
Designation | Funders | |
---|---|---|
2023/01/01 - 2024/06/30 | Deconstructing the Cell Communication Routes of mutant KRAS Colorectal Liver to Lung Metastasis: improving patient survival
2022.05346.PTDC
Research team member
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2019 - 2021 | MAGICIAM: a MAcrophaGe Immunomodulatory-delivery system to prevent Cancer Invasion And Metastasis
POCI-01-0145-FEDER-031859
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2021 | Pre-clinical evaluation of novel chemical compounds for cancer treatment: tackling unmet clinical needs
POCI-01-0145-FEDER-031354
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2019 | Influence of an optimized combined dietary and exercise intervention on cytokine profile and NK cell infiltration of the tumor:
an exploratory pilot study
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Sociedade Portuguesa de Gastroenterologia
Concluded
|
2017 - 2019 | Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti¬cancer therapy
POCI-01-0145-FEDER-016390
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Instituto de Medicina Molecular, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
2016 - 2019 | Advancing cancer research: from basic knowledge to application
NORTE-01-0145-FEDER-000029
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
N2020 program
Concluded
|
2017 - 2018 | OncoAdvanC+: Bringing new solutions for cancer therapy
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
RESOLVE program
Concluded
|
2014 - 2018 | Epithelial stromal crosstalk as a major driver of colorectal cancer development and progression: an approach to identify its
master regulators
IF/00136/2013/CP1184/CT0003
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2015 - 2016 | Mesenchymal stem cells in inflamatory bowel disease: therapeutic strategy or cancer promoters?
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
GEDII |
2013 - 2015 | Functional Significance of E-cadherin Germline Missense Mutations in Diffuse Gastric Cancer
POCTI/CBO/44849/2002
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2013 - 2015 | Molecular mechanisms underlying cancer cell invasion in two cancer disease models, gastric and breast
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Concluded
|
2008 - 2011 | MLK3, a new mutated gene in MSI colorectal cancer
PTDC/SAU-OBD/68310/2006
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2005 - 2008 | In mismatch repair deficiency colorectal cancer are BRAF and KRAS new prognostic and therapeutic tools?
POCI/SAU-OBS/56921/2004
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Book chapter |
|
Conference poster |
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Journal article |
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Preprint |
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Other
Other output |
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Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2019 | Molecular study advances: The impact on patients’ selection for CRT | Jornadas Portuguesas de Cirurgia – Colorectal cancer pathology: a multidisciplinar approach
Fundação Cupertino de Miranda (Porto, Portugal)
|
2018 | KRAS mediates colorectal cancer cell invasion induced by fibroblasts | International Conference on Tumor Microenvironment Progression, Therapy and Prevention
The International Cancer Microenvironment Society (Lisbon, Portugal)
|
2017 | ITGA6 as a molecular mediator of KRAS-, BRAF- and PIK3CA-induced colorectal cancer stem cell phenotype | Translating Colorectal Cancer Research workshop
Cost Action BM1 206 (Porto, Portugal)
|
2014 | How oncogenes and non-neoplastic components play together for colorectal cancer development | 4th i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal (Póvoa de Varzim, Portugal)
|
2014 | Medicina molecular: da investigação à prática clínica. A contribuição da investigação no tratamento do cancro colo-retal | III In4Med
Universidade de Coimbra (Coimbra, Portugal)
|
2013 | MAPK signaling activation in colorectal cancer | 7th National Meeting on Cell Signalling - SINAL 2013
Universidade de Aveiro (Aveiro, Portugal)
|
2013 | N-RAS mutations in colorectal cancer. Mechanisms of oncogenesis and therapeutic implications | Colrain meeting
(Colrain, United States)
|
2010 | Mapk oncogenic activation in MSI gastrointestinal tumours | 1st i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal (Póvoa de Varzim, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2021/01 - Current | Deciphering the role of cholesterol as a mediator of oncogenic signaling and immune regulation in colorectal cancer
Supervisor of Ana Luísa Machado
|
Biomedicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
|
2019 - Current | Targeting HER2-positive gastric and esophageal cancers with functionalized lipid nanoparticles of docetaxel: development and
characterization of thermosensitive in situ gels for intratumoral drug delivery
Co-supervisor of Ana Camila Gomes Marques
|
Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2020 - 2024 | The role of BRAF V600E mutation and inflammation in the development of colorectal cancer
Supervisor of Susana Mendonça
|
Biomedicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
|
2020 - 2024 | Identification of therapeutic targets and disease biomarkers for mutant KRAS cancer patients: fulfilling an unmet clinical
need
Supervisor of Flávia Martins
|
Biomedicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
|
2022/02/01 - 2022/07/31 | Elucidating the mechanisms of colorectal cancer
Co-supervisor
|
Biomedical Engineering (Master) |
2021/09/01 - 2022/07/31 | The role of hypoxia on immunomodulation at the colon cancer microenvironment.
Co-supervisor
|
Oncology (Master) |
2021/09/01 - 2022/07/31 | Evaluation of the impact of 2D versus 3D cell culture systems in the communication and modulation of the tumour microenvironment
Supervisor
|
Oncobiology (Master) |
2018 - 2022 | Exploring the impact of mutant kras on epithelial-fibroblasts interactions during coloraractal initiation and progression
Supervisor of Patrícia Dias Carvalho
|
Patologia e Genética Molecular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2020/09 - 2021/07 | Deciphering the functional role of KRAS-induced SUSD2 downregulation in colorectal cancer
Supervisor of Diogo Coelho
|
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2017 - 2021 | Centriole aberrations and cancer stem cells
Co-supervisor of Irina Suheila Martins Leal Fonseca
|
Graduate Programme Science for Development (PhD)
Universidade Nova de Lisboa, Portugal
|
2020 - 2020 | Identification of Biomarkers of Resistance to Immune Checkpoint Inhibitors
Supervisor of Tânia Rodrigues Vieira
|
Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
|
2020 - 2020 | Pre-clinical evaluation of novel chemical compounds for cancer treatment: tackling unmet clinical needs
Supervisor of Ana Sofia Valdeira
|
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
2018 - 2019 | To identify the key molecular players in mediating colorectal cancer cell invasion and metastization induced by cancer-associated
fibroblasts
Supervisor of Flávia Martins
|
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
2017 - 2019 | Influence of KRAS activation in the colorectal cancer immunosurveillance
Supervisor of Ana Luísa Machado
|
Bioquímica em Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
|
2017 - 2019 | CSC niche: the role of cellular and non-cellular components from the tumour microenvironment
Supervisor of Susana Mendonça
|
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
2016 - 2018 | To identify the key molecular players in mediating colorectal cancer cell invasion and metastization induced by cancer-associated
fibroblasts
Supervisor of Patrícia Dias Carvalho
|
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
|
2017 - 2017 | Cancer-associated fibroblasts and tumor-associated macrophages: exploring their mutual regulation.
Supervisor of Carlos Ferreira Guimarães
|
Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
|
2015 - 2016 | Modulation of colorectal cancer stem cell pool and its crosstalk with tumor microenvironment by KRas, BRaf, and PIK3CA mutations
Supervisor of André Emanuel Serra Roma
|
Investigação Biomédica (Master)
Universidade de Coimbra, Portugal
|
2014 - 2014 | Characterization of the expression of intestinal homeostasis-related signaling pathways in KRAS mutant colorectal cancer cell
lines
Supervisor of Anjali Balgobind
|
Van Hall Larenstein University of Applied Sciences, Netherlands
|
2009 - 2010 | Cellular effects of MLK3 mutations
Co-supervisor of Ana Teresa Ferreira Correia Pinto
|
Universidade de Coimbra, Portugal
|
2007 - 2009 | MLK3, a new cancer-related gene and its associated target molecules
Co-supervisor of Filipa Sousa
|
Universidade do Porto, Portugal
|
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2018 - 2018 | Technology transfer and entrepreneurship program | HiTech Program 2018 Ed.
HiSeedTech, Portugal
|
2017 - 2017 | Technology transfer and entrepreneurship program | RESOLVE program, 2nd Ed.
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2020 | Role of ccl18 on colorectal cancer immune modulation
(Thesis) Main arguer
|
Ana Manuela Canha Borges (Master)
Universidade do Porto Faculdade de Medicina, Portugal
|
2020 | Seeking for new p53-activating agents: effective therapies for colorectal cancer
(Thesis) Arguer
|
Helena Isabel Nogueira Ramos Rocha (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2019 | Mitochondrial dynamics in thyroid cancer: unravelling the role of DRP1
(Thesis) Main arguer
|
Sara Alexandra de Sousa Barambana (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2019 | Identification of novel prognostic biomarkers for stage II colorectal cancer
(Thesis) Main arguer
|
Filipa Alexandra Mesquita Amorim (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2019 | Role of ccl18 on colorectal cancer immune modulation
(Thesis) Main arguer
|
Ana Manuela Canha Borges (Master)
Universidade do Porto Faculdade de Medicina, Portugal
|
2019 | Targeting antigen presenting cells: chitosan/poly (y-glutamic acid) nanoparticles as adjuvants to anticancer therapy
(Thesis) Arguer
|
Flávia Raquel Teixeira de Castro (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
2018 | Role of the RNA-binding protein MEX3A in intestinal carcinogenesis
(Thesis) Main arguer
|
Dalila de Jesus Lopes Mexieiro (Master)
Universidade do Porto Faculdade de Medicina, Portugal
|
2014 | Complex cell-based model of intestinal permeability
(Thesis) Main arguer
|
Joana Costa (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2018 - 2019 | The Colorectal Cancer Working Group | Member of the Scientific Committee |
Committee member
Activity description Role |
Institution / Organization | |
---|---|---|
2019 - 2024 | Member of Maria José Silveira PhD's committee. “Immunomodulatory functionalized nanoparticles to improve chemotherapeutic
treatment in metastatic colorectal cancer”
Advisor / Consultant
|
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal |
Conference scientific committee
Conference name | Conference host | |
---|---|---|
2018 - 2018 | International Conference on Tumor Microenvironment, Progression, Therapy & Prevention | PT Meeting Center |
2018 - 2018 | Cancro colorretal em Portugal: da investigação à prevenção e ao tratamento | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
Consulting
Activity description | Institution / Organization | |
---|---|---|
2017 - 2017 | Papel de Hakai durante la progresión tumoral: implicaciones sobre la plasticidade epitelial | Universidade da Coruña, Spain |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2015 - Current | Module on Tumor Microenvironment | GABBA PhD Programme | Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal |
2023/09/01 - 2024/06/30 | Honorary Collaborator, Department of Anatomic Pathology, Microbiology, Preventive Medicine and Public Health and Legal Medicine and Forensics, Valladolid University (Spain), 2023-2024. BSc degree in Biomedicine and Advanced Therapies; Curricular unit: “Morpho-structural and Molecular Pathology of Human Disease”; Topic: “Molecular bases of development, clinical course, and therapeutic response of esophageal, stomach, and colon tumors”. | Molecular bases of development, clinical course, and therapeutic response of esophageal, stomach, and colon tumors (Bachelor) | Universidad de Valladolid, Spain |
Journal scientific committee
Journal title (ISSN) | Publisher | |
---|---|---|
2019 - Current | Cells (2073-4409) | MDPI |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2019 - 2024 | Mentoring Junior Researcher (postdoctoral level) on "The role of exosomes in metastatic colorectal cancer" | Joana Carvalho |
2020 - 2020 | Visiting MSc student from the Oncology Master Program, ICBAS, UP | Diogo Coelho |
2020 - 2020 | Visiting PhD student from University of Sciences and Technology Houari Boumediene, Algeria. "Testing the effect of repurposing drugs for colorectal cancer therapy". | Allal Badredine |
2019 - 2020 | Mentoring Junior Researcher (postdoctoral level) on "Pre-clinical evaluation of novel chemical compounds for cancer treatment: tackling unmet clinical needs" | Andreia Ribeiro |
2016 - 2016 | Visiting PhD student from University of Vigo, Spain. “Metastatic functionalities of colorectal cancer cell lines are influenced by expression levels of CD26/DPP4 and partially inhibited by sitagliptin”. | Marta Quiroga |
Distinctions
Award
2021 | Assistant Researcher Contract
Fundação para a Ciência e a Tecnologia, Portugal
|
2020 | Best Oral Presentation 2020
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2019 | ImmunoTools special Award 2019
ImmunoTools, Germany
|
2018 | Best Innovation Project Prize
RESOLVE program, Portugal
|
2016 | EACR prize for the best poster at the 2nd International ASPIC Meeting
European Association For Cancer Research, United Kingdom
|
2014 | Assistant Researcher Contract
Fundação para a Ciência e a Tecnologia, Portugal
|
2011 | Post-Doctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
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2006 | Doctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
|