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J. Dupont is an experienced researcher focused on the metabolism and the physiology of reproduction in mammals. After completion of her PhD in animal physiology, she was a postdoctoral fellow at National Institute of Health (Bethesda, USA). Since 2001, she works as a principal investigator on the interactions between the metabolism and the reproductive functions in different species including bovine species. More precisely she studied the role of adipokines (molecules produced by adipose tissue) on the bovine ovarian functions. She was a leader of a research team (12 permanent people, 2008-2013) on this thematic. She already coordinated several national and international research programs on the fertility of the dairy cows including an european project called « Pluridisciplinary study for a RObust and sustainabLe Improvement of Fertility In Cows- PROLIFIC » (2013-2017). PROLIFIC involved 13 partners including 8 european countries. She is an associated editor for the « Reproduction » journal and she has already published more than 170 peer-reviewed papers.
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Identification

Personal identification

Full name
DUPONT Joëlle

Citation names

  • Joëlle, DUPONT

Author identifiers

Ciência ID
B214-E566-71FB
ORCID iD
0000-0002-8046-7705
Education
Degree Classification
1999
Concluded
 Animal Physiology (Doctorat)
Université de Tours Institut Universitaire de Technologie de Tours, France
1996
Concluded
 Agronomy (Licence)
AgroParisTech - Centre de Grignon, France
Affiliation

Science

Category
Host institution 		Employer
2008 - Current Coordinating Researcher (Research) INRA UMR-PRC Unit, INRAE, Nouzilly, France
INRA UMR-PRC Unit, INRAE, Nouzilly, France
2008 - 2013 Principal Investigator (Research) INRA UMR-PRC Unit, INRAE, Nouzilly, France
INRA UMR-PRC Unit, INRAE, Nouzilly, France
2000 - 2008 Researcher (Research) INRA UMR-PRC Unit, INRAE, Nouzilly, France
INRA UMR-PRC Unit, INRAE, Nouzilly, France
1999 - 2001 Postdoc (Research) National Institutes of Health (NIH), Bethesda, USA, United States
National Institutes of Health (NIH), Bethesda, USA, United States
Projects

Grant

Designation Funders
2016 - 2021 Puberty and early reproduction in dairy heifers: assessment of biological limits-VEAUFAST
32000828
Principal investigator
2017 - 2018 Validation and characterization of a tissue ablation process and the consequences on ovarian scarring in dairy cows
00001414
Other
2013 - 2017 Development of assays for molecules of interest in plasma and other biological fluids and expression at the level of the embryo in dairy cows-VALOPROT
32000495
Principal investigator
2012 - 2016 Identification of indicators of body composition and fertility in poultry and dairy cows- ADIPOFERTIKINES
32000407
Principal investigator
2010 - 2014 A study of the ovarian molecular mechanisms involved in the reduction of fertility in dairy cows and the impact of fatty acid supplementation on reproduction and metabolism-FERTINUT
32000330
Principal investigator
2005 - 2009 Genetic determinism and metabolic study of fertility problems in high-producing dairy cows - Fertility 1 and 2
ANR-06-GANI-0004
Principal investigator
Agence nationale de la recherche, France

Other

Designation Funders
2016 - 2018 Understanding role of the adipokine Apelin in ovarian functions for fertility in cows and pigs
35203VC
Principal investigator
2013 - 2017 Pluridisciplinary study for a RObust and sustainabLe Improvement of Fertility In Cows- PROLIFIC
311776
Other
Outputs

Publications

Journal article
  1. Piras, Cristian; Morittu, Valeria Maria; Spina, Anna Antonella; Soggiu, Alessio; Greco, Viviana; Ramé, Christelle; Briant, Eric; et al. "Unraveling the Adipose Tissue Proteome of Transition Cows through Severe Negative Energy Balance". Animals 9 12 (2019): 1013. http://dx.doi.org/10.3390/ani9121013.
    10.3390/ani9121013
  2. Patrycja Kurowska; Ewa Mlyczynska; Monika Dawid; Malgorzata Opydo-Chanek; joelle dupont; Agnieszka Rak. "In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3/1, AKT, and STAT3". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/22/5816.
    10.3390/ijms20225816
  3. Mellouk, Namya; Rame, Christelle; Naquin, Delphine; Jaszczyszyn, Yan; Touzé, Jean-Luc; Briant, Eric; Guillaume, Daniel; et al. "Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system". PLOS ONE 14 9 (2019): e0222954. http://dx.doi.org/10.1371/journal.pone.0222954.
    10.1371/journal.pone.0222954
  4. Mellouk, Namya; Ramé, Christelle; Diot, Mélodie; Briant, Eric; Touzé, Jean-Luc; Guillaume, Daniel; Froment, Pascal; Dupont, Joëlle. "Possible involvement of the RARRES2/CMKLR1-system in metabolic and reproductive parameters in Holstein dairy cows". Reproductive Biology and Endocrinology 17 1 (2019): http://dx.doi.org/10.1186/s12958-019-0467-x.
    10.1186/s12958-019-0467-x
  5. Coyral-Castel, S; Ramé, C; Cognié, J; Lecardonnel, J; Marthey, S; Esquerré, D; Hennequet-Antier, C; et al. "KIRREL is differentially expressed in adipose tissue from ‘fertil+’ and ‘fertil-’ cows: in vitro role in ovary?". Reproduction 155 2 (2018): 181-196. http://dx.doi.org/10.1530/rep-17-0649.
    10.1530/rep-17-0649
  6. Mellouk, N.; Rame, C.; Touzé, J.L.; Briant, E.; Ma, L.; Guillaume, D.; Lomet, D.; et al. "Involvement of plasma adipokines in metabolic and reproductive parameters in Holstein dairy cows fed with diets with differing energy levels". Journal of Dairy Science 100 10 (2017): 8518-8533. http://dx.doi.org/10.3168/jds.2017-12657.
    10.3168/jds.2017-12657
  7. Roche, J; Ramé, C; Reverchon, M; Mellouk, N; Rak, A; Froment, P; Dupont, J. "Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells". Reproduction 153 5 (2017): 589-603. http://dx.doi.org/10.1530/rep-16-0677.
    10.1530/rep-16-0677
  8. Ntallaris, T.; Humblot, P.; Båge, R.; Sjunnesson, Y.; Dupont, J.; Berglund, B.. "Effect of energy balance profiles on metabolic and reproductive response in Holstein and Swedish Red cows". Theriogenology 90 (2017): 276-283. http://dx.doi.org/10.1016/j.theriogenology.2016.12.012.
    10.1016/j.theriogenology.2016.12.012
  9. Reverchon, Maxime; Rame, Christelle; Bunel, Audrey; Chen, Wenyong; Froment, Pascal; Dupont, Joëlle. "VISFATIN (NAMPT) Improves in Vitro IGF1-Induced Steroidogenesis and IGF1 Receptor Signaling Through SIRT1 in Bovine Granulosa Cells1". Biology of Reproduction 94 3 (2016): http://dx.doi.org/10.1095/biolreprod.115.134650.
    10.1095/biolreprod.115.134650
  10. Elis, Sebastien; Freret, Sandrine; Desmarchais, Alice; Maillard, Virginie; Cognié, Juliette; Briant, Eric; Touzé, Jean-Luc; et al. "Effect of a long chain n-3 PUFA-enriched diet on production and reproduction variables in Holstein dairy cows". Animal Reproduction Science 164 (2016): 121-132. http://dx.doi.org/10.1016/j.anireprosci.2015.11.020.
    10.1016/j.anireprosci.2015.11.020
  11. Elis, Sebastien; Desmarchais, Alice; Maillard, Virginie; Uzbekova, Svetlana; Monget, Philippe; Dupont, Joëlle. "Cell proliferation and progesterone synthesis depend on lipid metabolism in bovine granulosa cells". Theriogenology 83 5 (2015): 840-853. http://dx.doi.org/10.1016/j.theriogenology.2014.11.019.
    10.1016/j.theriogenology.2014.11.019
  12. Reverchon, Maxime; Bertoldo, Michael J.; Ramé, Christelle; Froment, Pascal; Dupont, Joëlle. "CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species1". Biology of Reproduction 90 5 (2014): http://dx.doi.org/10.1095/biolreprod.113.117044.
    10.1095/biolreprod.113.117044
  13. Reverchon, Maxime; Ramé, Christelle; Cognié, Juliette; Briant, Eric; Elis, Sébastien; Guillaume, Daniel; Dupont, Joëlle. "Resistin in Dairy Cows: Plasma Concentrations during Early Lactation, Expression and Potential Role in Adipose Tissue". PLoS ONE 9 3 (2014): e93198. http://dx.doi.org/10.1371/journal.pone.0093198.
    10.1371/journal.pone.0093198
  14. Elis, Sebastien; Coyral-Castel, Stephanie; Freret, Sandrine; Cognié, Juliette; Desmarchais, Alice; Fatet, Alice; Rame, Christelle; et al. "Expression of adipokine and lipid metabolism genes in adipose tissue of dairy cows differing in a female fertility quantitative trait locus". Journal of Dairy Science 96 12 (2013): 7591-7602. http://dx.doi.org/10.3168/jds.2013-6615.
    10.3168/jds.2013-6615
  15. Coyral-Castel, S.; Faverdin, P.; Ramé, C.; Fréret, S.; Guillaume, D.; Fritz, S.; Dupont, J.. "Significant differences in fertility between dairy cows selected for one QTL located on bovine chromosome 3 are not attributable to energy balance, although eating behaviour is affected". animal 7 4 (2012): 610-617. http://dx.doi.org/10.1017/s1751731112002133.
    10.1017/s1751731112002133
  16. Coyral-Castel, S.; Brisard, D.; Touzé, J.-L.; Dupont, M.; Ramé, C.; Uzbekova, S.; Dupont, J.. "Analysis of in vivo oocyte maturation, in vitro embryo development and gene expression in cumulus cells of dairy cows and heifers selected for one fertility quantitative trait loci (QTL) located on BTA3". Theriogenology 77 9 (2012): 1822-1833.e1. http://dx.doi.org/10.1016/j.theriogenology.2011.12.028.
    10.1016/j.theriogenology.2011.12.028
  17. Maillard, Virginie; Froment, Pascal; Ramé, Christelle; Uzbekova, Svetlana; Elis, Sébastien; Dupont, Joëlle. "Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation". REPRODUCTION 141 4 (2011): 467-479. http://dx.doi.org/10.1530/rep-10-0419.
    10.1530/rep-10-0419
  18. Tosca, Lucie; Ramé, Christelle; Chabrolle, Christine; Tesseraud, Sophie; Dupont, Joëlle. "Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells". REPRODUCTION 139 2 (2010): 409-418. http://dx.doi.org/10.1530/rep-09-0351.
    10.1530/rep-09-0351
  19. Maillard, Virginie; Uzbekova, Svetlana; Guignot, Florence; Perreau, Christine; Ramé, Christelle; Coyral-Castel, Stéphanie; Dupont, Joëlle. "Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development". Reproductive Biology and Endocrinology 8 1 (2010): 23. http://dx.doi.org/10.1186/1477-7827-8-23.
    10.1186/1477-7827-8-23
  20. Uzbekova, Svetlana; Salhab, Mohamad; Perreau, Christine; Mermillod, Pascal; Dupont, Joëlle. "Glycogen synthase kinase 3B in bovine oocytes and granulosa cells: possible involvement in meiosis during in vitro maturation". REPRODUCTION 138 2 (2009): 235-246. http://dx.doi.org/10.1530/rep-09-0136.
    10.1530/rep-09-0136
  21. Tosca, Lucie; Uzbekova, Svetlana; Chabrolle, Christine; Dupont, Joëlle. "Possible Role of 5'AMP-Activated Protein Kinase in the Metformin-Mediated Arrest of Bovine Oocytes at the Germinal Vesicle Stage During In Vitro Maturation1". Biology of Reproduction 77 3 (2007): 452-465. http://dx.doi.org/10.1095/biolreprod.107.060848.
    10.1095/biolreprod.107.060848
  22. Tosca, Lucie; Chabrolle, Christine; Uzbekova, Svetlana; Dupont, Joëlle. "Effects of Metformin on Bovine Granulosa Cells Steroidogenesis: Possible Involvement of Adenosine 5' Monophosphate-Activated Protein Kinase (AMPK)1". Biology of Reproduction 76 3 (2007): 368-378. http://dx.doi.org/10.1095/biolreprod.106.055749.
    10.1095/biolreprod.106.055749
Activities

Committee member

Activity description
Role 		Institution / Organization
2015 - Current animal ethical regional (Val de Loire) committe INRAE, Centre Val de Loire 37380 Nouzilly France, France
2018 - 2021 Scientific committee for National Agency for Food, Environmental and Occupational Health Security (animal feed committee)
2017 - 2021 Scientific committee of INSERM (Animal and human Physiology)
2014 - 2018 National Scientific INRAE board INRAE, Centre Val de Loire 37380 Nouzilly France, France
2012 - 2017 scientific committee of CoNRS (Animal Physiology)
2011 - 2016 Animal Physiology and Farming System department board INRAE

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Reproduction (1741-7899) Bioscientifica
2019 - Current IJMS