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Concluiu o Doutoramento em Biofísica em 2001 pela Universidade de Lisboa, o Mestrado em Biofísica em 1997 pela Faculdade de Ciências da Universidade de Lisboa e a Licenciatura em Física Tecnológica em 1995 Faculdade de Ciências da Universidade de Lisboa. É Professor Auxiliar na Faculdade de Ciências da Universidade de Lisboa. Especialização em metodologia para a análise de sinais e imagens médicos, em particular ressonância magnética funcional e electroencefalografia, com ênfase em conectividade cerebral e aplicação a patologias como epilepsia e tumores.
Identification

Personal identification

Full name
Alexandre da Rocha Freire de Andrade

Citation names

  • Andrade, Alexandre

Author identifiers

Ciência ID
B117-5C25-B0E1
ORCID iD
0000-0002-8107-7338
Google Scholar ID
https://scholar.google.com/citations?user=8YeTkGYAAAAJ&hl=en
Researcher Id
K-6236-2012

Knowledge fields

  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2001
Concluded
 PhD in Biophysics (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Incorporation of anatomical information into the analysis of brain functional Magnetic Resonance Imaging (fMRI) data" (THESIS/DISSERTATION)
 Very Good
1997
Concluded
 MSc in Biophysics (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
""Ressonância Magnética Funcional: Questões Metodológicas e Aplicação ao Estudo da Recuperação da Afasia"" (THESIS/DISSERTATION)
 Very Good
1995
Concluded
 BSc in Technological Physics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2001/11/05 - 2002/08/31 Postdoc (Research) MRC Cognition and Brain Sciences Unit, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2002/09/01 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2020/11/01 - 2024/10/11 COST Action 19127 - Cognitive decline in Nephro-Neurology: European Cooperative Target
Researcher
Ongoing
2017/08/01 - 2021/03/29 COST Action 16118: Expert network on brain malformations
CA16118
Researcher
Ongoing
2017/02/01 - 2021/01/31 Redes sinápticas e abordagens compreensivas de medicina personalizada em doenças neurocomportamentais ao longo da vida
SAICTPAC/0010/2015
Universidade de Coimbra, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/11/01 - 2017/10/31 Ressonância Magnética Funcional de repouso no planeamento cirúrgico da epilepsia.
Tecnifar BICE
Principal investigator
Universidade de Lisboa Faculdade de Ciências, Portugal
 Tecnifar
Concluded
2012/01/01 - 2015/06/30 Avaliação multi-paramétrica da conectividade do sistema límbico em doentes com epilepsia pós-traumática
PTDC/SAU-ENB/120718/2010
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2014/06/30 Neuroimagem dinâmica não-invasiva em epilepsia
PTDC/SAU-ENB/112294/2009
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto de Sistemas e Robótica, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/08/31 Investigação neuroimagiológica de mecanismos de aprendizagem no cérebro humano: novas abordagens metodológicas
PTDC/SAU-BEB/65977/2006
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Rodrigues, João; Andrade, Alexandre; Leal, Alberto. "Os espasmos infantis associam-se a surtos de actividade EEG rítmica em múltiplas bandas de alta frequência entre 15-300 Hz, Análise de um caso clínico submetido a cirurgia da epilepsia". Paper presented in 27º Encontro Nacional de Epileptologia, Coimbra, 2015.
    Published
Conference poster
  1. Guido, Joana; Lacerda, Luís; Andrade, Alexandre; Ferreira, Hugo; Clark, Chris. "Integration of multi-shell diffusion imaging derived metrics in tractography reconstructions". Paper presented in 25th Meeting of the Organization for Human Brain Mapping, 2019.
  2. Abidin, Anas Zainul; D'Souza, Adora M.; Nagarajan, Mahesh B.; Wismüller, Axel. "Detecting Abnormal Functional Connectivity Patterns Using Stacked Autoencoders". Paper presented in 25th Meeting of the Organization for Human Brain Mapping, 2019.
    10.1117/12.2217315
  3. Gens, João; Brito, Joana; Andrade, Alexandre; Koschutnig, Karl; Ferreira, Hugo; Schwerdtfeger, Andreas; Pfurtscheller, Gert. "Brain circuits involved in self-paced motion: the influence of 0.1 Hz waves". Paper presented in 22nd Meeting of the Organization for Human Brain Mapping, 2016.
  4. Santos, Francisco; Nunes, Rita G.; Rodrigues, João; Leal, Alberto; Andrade, Alexandre. "Unravelling the Dynamics of Epilepsy Using Effective Connectivity and Hemodynamic Estimation: Two Case Studies". Paper presented in 32nd anual meeting of the European Society of Magnetic Resonance in Medicine and Biology, 2015.
  5. Brito, Joana; Andrade, Alexandre; Ferreira, Hugo; Fink, David; Pfurtscheller, Gert. "Dynamics of slow BOLD oscillations during rest and task states". Paper presented in 32nd anual meeting of the European Society of Magnetic Resonance in Medicine and Biology, 2015.
  6. Rodrigues, João; Figueiredo, Patrícia; Andrade, Alexandre. "Lag-based connectivity applied to fMRI: tricky but not hopeless". Paper presented in 20th Meeting of the Organization for Human Brain Mapping, 2014.
  7. Andrade, Alexandre; Ferreira, Hugo; Koschutnig, Karl; Pfurtscheller, Gert. "Slow waves in rest and paced motion studied with Wavelet Transform Coherence: an fMRI study". Paper presented in 20th Meeting of the Organization for Human Brain Mapping, 2014.
  8. Tavares, Vânia; Brito,Joana; Ferreira, Hugo; Andrade, Alexandre; Koschutnig, Karl; Pfurtscheller, Gert. "Temporal clustering analysis to evaluate slow oscillations around 0.1 Hz". Paper presented in 20th Meeting of the Organization for Human Brain Mapping, 2014.
  9. Lacerda, Luís; Neto-Henriques, Rafael; Dell'Acqua, F; Nunes, Rita; Andrade, Alexandre; Manaças, Rui; Gonçalves-Pereira, P; Ferreira, Hugo. "Functional and Structural Connectivity of the Lymbic System Using Automatic Parcellation". Paper presented in 19th Meeting of the Organization for Human Brain Mapping, Seattle, EUA, 2013.
  10. Rodrigues, João; Figueiredo, Patrícia; Andrade, Alexandre. "Applicability of lag-based measures to fMRI: Influence of Experimental Parameters". Paper presented in 19th Meeting of the Organization for Human Brain Mapping, 2013.
  11. Caseiro, Paulo; Fonseca-Pinto, Rui; Andrade, Alexandre. "Screening of Obstructive Sleep Apnea in Awake Subjects". Paper presented in 21st Congress of the European Sleep Research Society, 2012.
  12. Caseiro, Paulo; Freire, Luís; Andrade, Alexandre. "Sleep Stage Scoring using EMD and Neural Networks". Paper presented in 21st Congress of the European Sleep Research Society, 2012.
Journal article
  1. Benghenia, Hadj Abdelkader; Zine-Eddine, Hadj Slimane; Alexandre, Andrade. "Automated Recognition of Sleep Apnea-Hypopnea Syndrome Using Continuous Wavelet Transform-Based Multiscale Dispersion Entropy of Single-Lead ECG Signal". Traitement du Signal 39 1 (2022): 341-353. http://dx.doi.org/10.18280/ts.390136.
    10.18280/ts.390136
  2. Pfurtscheller, G.; Schwerdtfeger, A.R.; Rassler, B.; Andrade, A.; Schwarz, G.. "MRI-related anxiety can induce slow BOLD oscillations coupled with cardiac oscillations". Clinical Neurophysiology 132 9 (2021): 2083-2090. http://dx.doi.org/10.1016/j.clinph.2021.05.021.
    10.1016/j.clinph.2021.05.021
  3. Fernandes, Tiago Timóteo; Direito, Bruno; Sayal, Alexandre; Pereira, João; Andrade, Alexandre; Castelo-Branco, Miguel. "The boundaries of state-space Granger causality analysis applied to BOLD simulated data: A comparative modelling and simulation approach". Journal of Neuroscience Methods 341 (2020): 108758. http://dx.doi.org/10.1016/j.jneumeth.2020.108758.
    Published • 10.1016/j.jneumeth.2020.108758
  4. Pfurtscheller, Gert; Rassler, Beate; Schwerdtfeger, Andreas R.; Klimesch, Wolfgang; Andrade, Alexandre; Schwarz, Gerhard; Thayer, Julian F.. "“Switch-Off” of Respiratory Sinus Arrhythmia May Be Associated With the Activation of an Oscillatory Source (Pacemaker) in the Brain Stem". Frontiers in Physiology 10 939 (2019): http://dx.doi.org/10.3389/fphys.2019.00939.
    Open access • Published • 10.3389/fphys.2019.00939
  5. Pfurtscheller, Gert; Schwerdtfeger, Andreas; Fink, David; Brunner, Clemens; Aigner, Christoph Stefan; Brito, Joana; Andrade, Alexandre. "MRI-related anxiety in healthy individuals, intrinsic BOLD oscillations at 0.1 Hz in precentral gyrus and insula, and heart rate variability in low frequency bands". PLOS ONE 13 11 (2018): e0206675. http://dx.doi.org/10.1371/journal.pone.0206675.
    Open access • Published • 10.1371/journal.pone.0206675
  6. Pfurtscheller, Gert; Schwerdtfeger, Andreas; Seither-Preisler, Annemarie; Brunner, Clemens; Aigner, Christoph Stefan; Calisto, João; Gens, João; Andrade, Alexandre. "Synchronization of intrinsic 0.1-Hz blood-oxygen-level-dependent oscillations in amygdala and prefrontal cortex in subjects with increased state anxiety". European Journal of Neuroscience 47 5 (2018): 417-426. http://dx.doi.org/10.1111/ejn.13845.
    10.1111/ejn.13845
  7. Pfurtscheller, Gert; Schwerdtfeger, Andreas; Brunner, Clemens; Aigner, Christoph; Fink, David; Brito, Joana; Carmo, Marciano P.; Andrade, Alexandre. "Distinction between Neural and Vascular BOLD Oscillations and Intertwined Heart Rate Oscillations at 0.1 Hz in the Resting State and during Movement". PLOS ONE 12 1 (2017): e0168097. http://dx.doi.org/10.1371/journal.pone.0168097.
    Open access • Published • 10.1371/journal.pone.0168097
  8. Pfurtscheller, Gert; Schwerdtfeger, Andreas R.; Seither-Preisler, Annemarie; Brunner, Clemens; Stefan Aigner, Christoph; Brito, Joana; Carmo, Marciano P.; Andrade, Alexandre. "Brain–heart communication: Evidence for “central pacemaker” oscillations with a dominant frequency at 0.1 Hz in the cingulum". Clinical Neurophysiology 128 1 (2017): 183-193. http://dx.doi.org/10.1016/j.clinph.2016.10.097.
    Published • 10.1016/j.clinph.2016.10.097
  9. Rodrigues, João; Andrade, Alexandre. "Synthetic neuronal datasets for benchmarking directed functional connectivity metrics". PeerJ 3 (2015): e923. http://dx.doi.org/10.7717/peerj.923.
    Open access • Published • 10.7717/peerj.923
  10. Rodrigues, João; Andrade, Alexandre. "Causal inference in neuronal time-series using adaptive decomposition". Journal of Neuroscience Methods 245 (2015): 73-90. http://dx.doi.org/10.1016/j.jneumeth.2015.02.013.
    Published • 10.1016/j.jneumeth.2015.02.013
  11. Pfurtscheller, Gert; Andrade, Alexandre; Koschutnig, Karl; Brunner, Clemens; da Silva, Fernando Lopes. "Initiation of voluntary movements at free will and ongoing 0.1-Hz BOLD oscillations in the insula: a pilot study". Frontiers in Integrative Neuroscience 8 (2014): http://dx.doi.org/10.3389/fnint.2014.00093.
    Open access • Published • 10.3389/fnint.2014.00093
  12. Rodrigues, João; Andrade, Alexandre. "Lag-based effective connectivity applied to fMRI: A simulation study highlighting dependence on experimental parameters and formulation". NeuroImage 89 (2014): 358-377. http://dx.doi.org/10.1016/j.neuroimage.2013.10.029.
    Published • 10.1016/j.neuroimage.2013.10.029
  13. Andrade, Alexandre. "Complexo e surpreendente". Gazeta da Física 37 3 (2014):
    Published
  14. Rodrigues, João; Andrade, Alexandre. "Instantaneous Granger Causality with the Hilbert-Huang Transform". ISRN Signal Processing 2013 (2013): 1-9. http://dx.doi.org/10.1155/2013/374064.
    Published • 10.1155/2013/374064
  15. Catarino, Ana; Andrade, Alexandre; Churches, Owen; Wagner, Adam P; Baron-Cohen, Simon; Ring, Howard. "Task-related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence". Molecular Autism 4 1 (2013): 1. http://dx.doi.org/10.1186/2040-2392-4-1.
    Published • 10.1186/2040-2392-4-1
  16. Rodrigues, J.; Andrade, A.. "A new approach for granger causality between neuronal signals using the empirical mode decomposition algorithm". Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012 (2012): 158-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863644846&partnerID=MN8TOARS.
    10.2316/P.2012.764-147
  17. Catarino, A.; Churches, O.; Baron-Cohen, S.; Andrade, A.; Ring, H.. "Atypical EEG complexity in autism spectrum conditions: A multiscale entropy analysis". Clinical Neurophysiology 122 12 (2011): 2375-2383. http://www.scopus.com/inward/record.url?eid=2-s2.0-80855148243&partnerID=MN8TOARS.
    10.1016/j.clinph.2011.05.004
  18. Catarino, A.; Luke, L.; Waldman, S.; Andrade, A.; Fletcher, P.C.; Ring, H.. "An fMRI investigation of detection of semantic incongruities in autistic spectrum conditions". European Journal of Neuroscience 33 3 (2011): 558-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251575302&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2010.07503.x
  19. Caseiro, P.; Fonseca-Pinto, R.; Andrade, A.. "Screening of obstructive sleep apnea using Hilbert-Huang decomposition of oronasal airway pressure recordings". Medical Engineering and Physics 32 6 (2010): 561-568. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955691804&partnerID=MN8TOARS.
    10.1016/j.medengphy.2010.01.008
  20. Fonseca-Pinto, R.; Caseiro, P.; Andrade, A.. "Image empirical mode decomposition (IEMD) in dermoscopic images: Artefact removal and lesion border detection". Proceedings of the 7th IASTED International Conference on Signal Processing, Pattern Recognition and Applications, SPPRA 2010 (2010): 341-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954570197&partnerID=MN8TOARS.
  21. Fonseca-Pinto, R.; Ducla-Soares, J.L.; Araújo, F.; Aguiar, P.; Andrade, A.. "On the influence of time-series length in EMD to extract frequency content: Simulations and models in biomedical signals". Medical Engineering and Physics 31 6 (2009): 713-719. http://www.scopus.com/inward/record.url?eid=2-s2.0-67549084737&partnerID=MN8TOARS.
    10.1016/j.medengphy.2009.02.001
  22. Xavier, R.; Laranjo, S.; Ducla-Soares, E.; Andrade, A.; Boto, J.P.; Santos-Bento, M.; Ducla-Soares, J.L.; Carvalho, L.S.; Rocha, I.. "The Valsalva maneuver revisited by wavelets". Revista Portuguesa de Cardiologia 27 4 (2008): 435-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549102082&partnerID=MN8TOARS.
  23. Ducla-Soares, J.L.; Santos-Bento, M.; Laranjo, S.; Andrade, A.; Ducla-Soares, E.; Boto, J.P.; Silva-Carvalho, L.; Rocha, I.. "Wavelet analysis of autonomic outflow of normal subjects on head-up tilt, cold pressor test, Valsalva manoeuvre and deep breathing". Experimental Physiology 92 4 (2007): 677-686. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347380115&partnerID=MN8TOARS.
    10.1113/expphysiol.2007.038026
  24. Andrade, Alexandre. "Magnetic fields and radiation in magnetic resonance imaging: present and future perspectives". Radioprotecção – Revista Oficial da Sociedade Portuguesa de Protecção Contra Radiações II 6,7,8,9 (2006): 81-88.
    Published
  25. Cox, S.M.L.; Andrade, A.; Johnsrude, I.S.. "Learning to like: A role for human orbitofrontal cortex in conditioned reward". Journal of Neuroscience 25 10 (2005): 2733-2740. http://www.scopus.com/inward/record.url?eid=2-s2.0-14944340222&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3360-04.2005
  26. Cachia, A.; Mangin, J.-F.; Rivière, D.; Kherif, F.; Boddaert, N.; Andrade, A.; Papadopoulos-Orfanos, D.; et al. "A primal sketch of the cortex mean curvature: A morphogenesis based approach to study the variability of the folding patterns". IEEE Transactions on Medical Imaging 22 6 (2003): 754-765. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042674006&partnerID=MN8TOARS.
    10.1109/TMI.2003.814781
  27. Andrade, A.; Kherif, F.; Mangin, J.-F.; Worsley, K.J.; Paradis, A.-L.; Simon, O.; Dehaene, S.; Le Bihan, D.; Poline, J.-B.. "Detection of fMRI activation using Cortical Surface Mapping". Human Brain Mapping 12 2 (2001): 79-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035144148&partnerID=MN8TOARS.
    10.1002/1097-0193(200102)12:2<79::AID-HBM1005>3.0.CO;2-I
  28. Poline, J.-B.; Andrade, A.; Kherif, F.; Paradis, A.-L.. "Using functional a priori information for the statistical analysis of single subject multi-task fMRI paradigms". NeuroImage 11 5 PART II (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-22244455411&partnerID=MN8TOARS.
  29. Andrade, A.; Kherif, F.; Mangin, J.-F.; Worsley, K.J.; Simon, O.; Dehaene, S.; Le Bihan, D.; Poline, J.-B.. "Cortical surface statistical parametric mapping". NeuroImage 11 5 PART II (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0001207637&partnerID=MN8TOARS.
  30. Andrade, A.; Paradis, A.-L.; Rouquette, S.; Poline, J.-B.. "Ambiguous results in functional neuroimaging data analysis due to covariate correlation". NeuroImage 10 4 (1999): 483-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032826973&partnerID=MN8TOARS.
    10.1006/nimg.1999.0479
  31. Silva, C.; Pimentel, I.R.; Andrade, A.; Foreid, J.P.; Ducla-Soares, E.. "Correlation dimension maps of EEG from epileptic absences". Brain Topography 11 3 (1999): 201-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032921547&partnerID=MN8TOARS.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Study of patho-connectomics using innovative approaches in functional magnetic resonance imaging data analysis
Supervisor
 Neurociências (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2022 The Development of Episodic Memory and Cognitive Control: Behavioural and Neural Insights from Adolescence
Co-supervisor
 NeurUlisboa Phd Programme (PhD)
Universidade de Lisboa Faculdade de Psicologia, Portugal
2012 - 2015 New methodologies for directed functional connectivity applied to brain neuroimaging research
Supervisor
 Engenharia Biomédica e Biofísica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2012 Analysis of the Anatomical and Functional Basis of Autism Spectrum Conditions using Magnetic Resonance Imaging and Electroencephalography
Co-supervisor
 Engenharia Biomédica e Biofísica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2011 Detecção Automática de Eventos em Sinais Polissonográficos por Meio de Análise em Tempo-Frequência: Aplicações à Medicina do Sono
Supervisor
 Engenharia Biomédica e Biofísica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2010 Novas abordagens ao estudo de sinais biomédicos. Análise em tempo-frequência e transformada de Hilbert-Huang
Supervisor
 Engenharia Biomédica e Biofísica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2007 Myocardial strain analysis with high temporal resolutionMRI tagging: extended 3D motion tracking in normal and LBBB hearts
Co-supervisor
 Biofísica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2018 - Current Nature Communications (2041-1723) Springer Science and Business Media LLC
2017 - Current Proceedings A
2016 - Current Journal of Neuroscience Methods (0165-0270) Elsevier
2016 - Current NeuroImage (1095-9572) Elsevier
2015 - Current Computers in Biology and Medicine (0010-4825) Elsevier
2015 - Current Molecular Autism (2040-2392) Springer (Biomed Central Ltd.)
2014 - Current Entropy (1099-4300) MDPI AG
2013 - Current Computer Methods and Programs in Biomedicine (0169-2607) Elsevier